JP4653170B2 - 透析システム - Google Patents
透析システム Download PDFInfo
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- JP4653170B2 JP4653170B2 JP2007527721A JP2007527721A JP4653170B2 JP 4653170 B2 JP4653170 B2 JP 4653170B2 JP 2007527721 A JP2007527721 A JP 2007527721A JP 2007527721 A JP2007527721 A JP 2007527721A JP 4653170 B2 JP4653170 B2 JP 4653170B2
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- JP
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- Prior art keywords
- housing
- dialysate
- exchange resin
- flow path
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/24—Dialysis ; Membrane extraction
- B01D61/30—Accessories; Auxiliary operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
- A61M1/1603—Regulation parameters
- A61M1/1605—Physical characteristics of the dialysate fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1694—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid
- A61M1/1696—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid with dialysate regeneration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
- A61M1/341—Regulation parameters by measuring the filtrate rate or volume
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3368—Temperature
Description
本出願は、2004年6月9日に出願されたU.S.予備出願シリアルNo.60/578,257についての優先権を主張し、この出願は、参考とすることによってここで組み込む。
分野
哺乳動物血液システムの透析用のシステムおよび方法。
背景
透析システムは、典型的には、血液を循環するための液圧システム、透析液を循環するための液圧システムおよび半透過性の膜を含む。血液システムおよび透析液システムは、膜の反対側に伸びる液体流路を有する。尿素およびその他の血液成分(しかし、血球ではない)は、血液および透析液の両方がを流れるにつれ、血液側から透析液側へと膜を横切って移動する。
透析液循環装置は、透析器、第1のハウジングおよび第2のハウジングを含む。第1のハウジングは、その第1のハウジングを介して流れる透析液にナトリウムを放出しうる材料を収容する。第2のハウジングは、その第2のハウジングを介して流れる透析液からナトリウムイオンを結合しうる材料を収容する。液圧導管部分は、透析器から第1のハウジングへ、第1のハウジングから第2のハウジングへ流れ、かつ、第2のハウジングから透析器へと流れを戻す透析液のための主要な流路の第1および第2のハウジングと透析器とを連結するために、透析器、第1のハウジングおよび第2のハウジング間に伸びるように設計される。
図面に概略的に示す透析システムは、装置クレームに挙げた要素の例である部分を有し、方法のクレームに挙げた要素の例である工程にて作動させることができる。かくして、示したシステムは、当業者が特許請求したクレームを使って製造および使用することのできる例を含む。これらは、ここで、請求項に列挙されていない制限を課することなく、特許達成の手段および最良のモード要件に合致するように記載する。
溶液のイオン組成をコントロールするための混合床イオン交換カラムの能力を確定するために、4つの実施例を試験した。使用した混合床イオン交換カラムは、The Purolite Company(Bala Cynwyd,PA)によって製造されたPurolite PCL 2011 MBIEカラムであった。このカラムは、以下の特性を有した:
Claims (27)
- 透析液循環装置であって、
(a) 透析器(20);
(b) その第1のハウジングを介して流れる透析液にナトリウムを放出しうる材料を収容する第1のハウジング(30);
(c) その第2のハウジングを介して流れる透析液からナトリウムイオンを結合しうる材料を収容する第2のハウジング(32);
(d) 透析器から第1のハウジングへ、第1のハウジングから第2のハウジングへ流れ、かつ、第2のハウジングから透析器へと流れを戻す透析液のための主要な流路の第1および第2のハウジングと透析器とを連結するために、透析器、第1のハウジングおよび第2のハウジング間に伸びるように設計された液圧導管部分(40、42、44);および、
(e) 迂回流路を画定するように設計された液圧導管部分(46)であって、該迂回流路が、第1のハウジングから透析器に流れを戻すことによって、第2のハウジングを迂回するように透析液のための流路を与える当該液圧導管部分(46)
を含む装置。 - 主要流路および迂回流路に沿って透析液の流れをコントロールするように作動する液流調節器(50)をさらに含む、請求項1に記載の装置。
- 第1のハウジングから出て来る透析液中のナトリウムイオン濃度を指示するように作動する計量計(70)をさらに含む、請求項2に記載の装置。
- 計量計(70)によって指示されるナトリウムイオン濃度に応答して調節器(50)を作動させるために調節器および計量計と相互に関連して作動するコントローラ(80)をさらに含む、請求項3に記載の装置。
- 液圧導管(114);液流調節器(116);および、透析器と液流連通した流体容器を含む容積測定用の限外濾過装置(110)をさらに含む、請求項1に記載の装置。
- 透析器(20)、第1のハウジング(30)、第2のハウジング(32)および液圧導管部分(40、42、44)が、非膨張性の容積を有する透析液循環システムの相互連結部分である、請求項1に記載の装置。
- 非膨張性の容積が、3リットル以下である、請求項6に記載の装置。
- 非膨張性の容積が、2リットル以下である、請求項6に記載の装置。
- 非膨張性の容積が、1.5リットル以下である、請求項6に記載の装置。
- 非膨張性の容積が、1リットルである、請求項6に記載の装置。
- 第2のハウジング(32)に収容される材料が、混合床イオン交換樹脂を含む、請求項1に記載の装置。
- 混合床イオン交換樹脂が、800mEq以下のナトリウムイオン結合容量を有する、請求項11に記載の装置。
- 混合床イオン交換樹脂が、600mEq以下のナトリウムイオン結合容量を有する、請求項11に記載の装置。
- 混合床イオン交換樹脂が、500mEq以下のナトリウムイオン結合容量を有する、請求項11に記載の装置。
- 混合床イオン交換樹脂が、カチオン交換樹脂とアニオン交換樹脂とを含む、請求項11に記載の装置。
- カチオン交換樹脂が、スルホン化された球形スチレン-ジビニルベンゼンコポリマーである、請求項15に記載の装置。
- アニオン交換樹脂が、球形第4級アミンスチレン-ジビニルベンゼンコポリマーである、請求項15に記載の装置。
- 透析液システムで使用する装置であって、
(a) その第1のハウジングを介して流れる透析液にナトリウムを放出しうる材料を収容する第1のハウジング(30);
(b) その第2のハウジングを介して流れる透析液からナトリウムイオンを結合しうる材料を収容するハウジング(32);
(c) 主要な流路を確定するように設計された液圧導管部分(40、42、44)であって、当該主要な流路は、第1ハウジング、第1ハウジングおよび第2ハウジング間の流路、並びに第2ハウジングを出る流路に流路を与える;
(d) 迂回流路を画定するように設計された液圧導管部分(46)であって、該迂回流路が、第1ハウジング及び第2ハウジング間の主要流路を、第2ハウジングを出る主要流路に連結する流路を与える;および
(e) 主要流路および迂回流路に沿う透析液の流れを制御するように作用する液流調節器(50)を含む装置。 - 第2ハウジング(32)に収容される材料が、混合床イオン交換樹脂である、請求項18に記載の装置。
- 混合床イオン交換樹脂が、カチオン交換樹脂とアニオン交換樹脂とを含む、請求項19に記載の装置。
- カチオン交換樹脂が、スルホン化された球形スチレン-ジビニルベンゼンコポリマーである、請求項20に記載の装置。
- アニオン交換樹脂が、球形第4級アミンスチレン-ジビニルベンゼンコポリマーである、請求項20に記載の装置。
- 混合床イオン交換樹脂が、800mEq以下のナトリウムイオン結合容量を有する、請求項19に記載の装置。
- 混合床イオン交換樹脂が、600mEq以下のナトリウムイオン結合容量を有する、請求項19に記載の装置。
- 混合床イオン交換樹脂が、500mEq以下のナトリウムイオン結合容量を有する、請求項19に記載の装置。
- 第1ハウジング(30)から出る透析液中のナトリウムイオン濃度を指示するように作動する計量計(70)をさらに含む、請求項18に記載の装置。
- 計量計(70)により指示されたナトリウムイオン濃度に応答して前記調節器(50)を作動させるために調節器および計量計と相互に関連して作動するコントローラー(80)をさらに含む、請求項26に記載の装置。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57825704P | 2004-06-09 | 2004-06-09 | |
PCT/US2005/020275 WO2005123230A2 (en) | 2004-06-09 | 2005-06-09 | Dialysis system |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2008502449A JP2008502449A (ja) | 2008-01-31 |
JP4653170B2 true JP4653170B2 (ja) | 2011-03-16 |
Family
ID=35510286
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007527721A Expired - Fee Related JP4653170B2 (ja) | 2004-06-09 | 2005-06-09 | 透析システム |
Country Status (5)
Country | Link |
---|---|
US (2) | US7776210B2 (ja) |
EP (1) | EP1784248B1 (ja) |
JP (1) | JP4653170B2 (ja) |
HK (1) | HK1113555A1 (ja) |
WO (1) | WO2005123230A2 (ja) |
Cited By (1)
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HK1113555A1 (en) | 2008-10-10 |
JP2008502449A (ja) | 2008-01-31 |
WO2005123230A2 (en) | 2005-12-29 |
WO2005123230A3 (en) | 2006-10-12 |
US7776210B2 (en) | 2010-08-17 |
US20050274658A1 (en) | 2005-12-15 |
EP1784248A2 (en) | 2007-05-16 |
EP1784248B1 (en) | 2014-07-30 |
US7947179B2 (en) | 2011-05-24 |
US20100326911A1 (en) | 2010-12-30 |
EP1784248A4 (en) | 2012-07-04 |
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