US20080253911A1 - Pumping Cassette - Google Patents

Pumping Cassette Download PDF

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Publication number
US20080253911A1
US20080253911A1 US11871787 US87178707A US2008253911A1 US 20080253911 A1 US20080253911 A1 US 20080253911A1 US 11871787 US11871787 US 11871787 US 87178707 A US87178707 A US 87178707A US 2008253911 A1 US2008253911 A1 US 2008253911A1
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US
Grant status
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Patent type
Prior art keywords
fluid
chamber
cassette
pump
membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11871787
Inventor
Jason A. Demers
Michael J. Wilt
Kevin L. Grant
James D. Dale
Brian Tracey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deka Products LP
Original Assignee
Deka Products LP
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Filing date
Publication date

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    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04POSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04BPOSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B53/00Component parts, details or accessories not provided for in, or of interest apart from, groups F04B1/00 - F04B23/00 or F04B39/00 - F04B47/00
    • F04B53/10Valves; Arrangement of valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/10Blood pumps; Artificial hearts; Devices for mechanical circulatory assistance, e.g. intra-aortic balloon pumps
    • A61M1/1037Pumps having flexible elements, e.g. with membranes, diaphragms, or bladder pumps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris with membranes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris with membranes
    • A61M1/1601Control or regulation
    • A61M1/1603Regulation parameters
    • A61M1/1605Physical characteristics of the dialysate fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris with membranes
    • A61M1/1621Constructional aspects thereof
    • A61M1/1635Constructional aspects thereof with volume chamber balancing devices between used and fresh dialysis fluid
    • A61M1/1639Constructional aspects thereof with volume chamber balancing devices between used and fresh dialysis fluid linked by membranes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris with membranes
    • A61M1/1654Dialysates therefor
    • A61M1/1656Apparatus for preparing dialysates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris with membranes
    • A61M1/1654Dialysates therefor
    • A61M1/1656Apparatus for preparing dialysates
    • A61M1/166Heating
    • A61M1/1664Heating with temperature control
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris with membranes
    • A61M1/1654Dialysates therefor
    • A61M1/1656Apparatus for preparing dialysates
    • A61M1/1666Apparatus for preparing dialysates by dissolving solids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris
    • A61M1/28Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
    • A61M1/287Dialysates therefor
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04POSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04BPOSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B13/00Pumps specially modified to deliver fixed or variable measured quantities
    • F04B13/02Pumps specially modified to deliver fixed or variable measured quantities of two or more fluids at the same time
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04POSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04BPOSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B23/00Pumping installations or systems
    • F04B23/04Combinations of two or more pumps
    • F04B23/06Combinations of two or more pumps the pumps being all of reciprocating positive-displacement type
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04POSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04BPOSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B41/00Pumping installations or systems
    • F04B41/06Combinations of two or more pumps
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04POSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04BPOSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00Machines, pumps, or pumping installations having flexible working members
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04POSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04BPOSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00Machines, pumps, or pumping installations having flexible working members
    • F04B43/02Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04POSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04BPOSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00Machines, pumps, or pumping installations having flexible working members
    • F04B43/02Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F04B43/06Pumps having fluid drive
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04POSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04BPOSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00Machines, pumps, or pumping installations having flexible working members
    • F04B43/02Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F04B43/06Pumps having fluid drive
    • F04B43/073Pumps having fluid drive the actuating fluid being controlled by at least one valve
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04POSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04BPOSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00Machines, pumps, or pumping installations having flexible working members
    • F04B43/02Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F04B43/06Pumps having fluid drive
    • F04B43/073Pumps having fluid drive the actuating fluid being controlled by at least one valve
    • F04B43/0733Pumps having fluid drive the actuating fluid being controlled by at least one valve with fluid-actuated pump inlet or outlet valves; with two or more pumping chambers in series
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04POSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04BPOSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00Machines, pumps, or pumping installations having flexible working members
    • F04B43/02Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F04B43/06Pumps having fluid drive
    • F04B43/073Pumps having fluid drive the actuating fluid being controlled by at least one valve
    • F04B43/0736Pumps having fluid drive the actuating fluid being controlled by at least one valve with two or more pumping chambers in parallel
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04POSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04BPOSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B45/00Pumps or pumping installations having flexible working members and specially adapted for elastic fluids
    • F04B45/02Pumps or pumping installations having flexible working members and specially adapted for elastic fluids having bellows
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04POSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04BPOSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B45/00Pumps or pumping installations having flexible working members and specially adapted for elastic fluids
    • F04B45/04Pumps or pumping installations having flexible working members and specially adapted for elastic fluids having plate-like flexible members, e.g. diaphragms
    • F04B45/053Pumps having fluid drive
    • F04B45/0536Pumps having fluid drive the actuating fluid being controlled by one or more valves
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04POSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04BPOSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B49/00Control, e.g. of pump delivery, or pump pressure of, or safety measures for, machines, pumps, or pumping installations, not otherwise provided for, or of interest apart from, groups F04B1/00 - F04B47/00
    • F04B49/22Control, e.g. of pump delivery, or pump pressure of, or safety measures for, machines, pumps, or pumping installations, not otherwise provided for, or of interest apart from, groups F04B1/00 - F04B47/00 by means of valves
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04POSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04BPOSITIVE DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B53/00Component parts, details or accessories not provided for in, or of interest apart from, groups F04B1/00 - F04B23/00 or F04B39/00 - F04B47/00
    • F04B53/06Venting
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
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    • F04B53/16Casings; Cylinders; Cylinder liners or heads; Fluid connections
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
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    • F04B7/02Piston machines or pumps characterised by having positively-driven valving the valving being fluid-actuated
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
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    • F04B9/00Piston machines or pumps characterised by the driving or driven means to or from their working members
    • F04B9/08Piston machines or pumps characterised by the driving or driven means to or from their working members the means being fluid
    • F04B9/10Piston machines or pumps characterised by the driving or driven means to or from their working members the means being fluid the fluid being liquid
    • F04B9/109Piston machines or pumps characterised by the driving or driven means to or from their working members the means being fluid the fluid being liquid having plural pumping chambers
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17STORING OF DISTRIBUTING GASES OR LIQUIDS
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    • A61M1/1001General aspects of blood pumps irrespective of pump type
    • A61M1/1006Blood pumps incorporated within another functional device, e.g. an oxygenator, a dialyser or a blood chamber
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    • A61M1/106Drive systems therefor, e.g. mechanically, electromechanically or skeletal muscle drive means using hydraulic or pneumatic means
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    • A61M1/1062Drive systems therefor, e.g. mechanically, electromechanically or skeletal muscle drive means using hydraulic or pneumatic means with application of vacuum at the blood pump, e.g. to accelerate filling
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    • A61M2205/128General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated valves
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T137/0324With control of flow by a condition or characteristic of a fluid
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T137/0324With control of flow by a condition or characteristic of a fluid
    • Y10T137/0379By fluid pressure
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T137/00Fluid handling
    • Y10T137/2496Self-proportioning or correlating systems
    • Y10T137/2514Self-proportioning flow systems
    • Y10T137/2521Flow comparison or differential response
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00Fluid handling
    • Y10T137/8593Systems
    • Y10T137/85978With pump
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00Fluid handling
    • Y10T137/8593Systems
    • Y10T137/85978With pump
    • Y10T137/86131Plural
    • Y10T137/86139Serial

Abstract

A pump cassette is disclosed. The pump cassette includes housing. The housing includes at least one fluid inlet line and at least one fluid outlet line. Also, the cassette includes at least one reciprocating pressure displacement membrane pump within the housing. The pressure pump pumps at least one fluid from the fluid inlet line to at least one of the fluid outlet line. Also, the cassette includes at least one mixing chamber within the housing. The mixing chamber is fluidly connected to the fluid outlet line.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • [0001]
    This application claims priority from the following U.S. Provisional Patent Applications, both of which are hereby incorporated herein by reference in their entireties:
  • [0002]
    U.S. Provisional Patent Application No. 60/904,024 entitled Hemodialysis System and Methods filed on Feb. 27, 2007; and
  • [0003]
    U.S. Provisional Patent Application No. 60/921,314 entitled Sensor Apparatus filed on Apr. 2, 2007 both of which are hereby incorporated by reference in their entireties.
  • TECHNICAL FIELD
  • [0004]
    The present invention relates to a pumping cassette for pumping fluid.
  • SUMMARY OF THE INVENTION
  • [0005]
    In accordance with one aspect of the pump cassette the cassette includes housing. The housing includes at least one fluid inlet line and at least one fluid outlet line. Also, the cassette includes at least one reciprocating pressure displacement membrane pump within the housing. The pressure pump pumps at least one fluid from the fluid inlet line to at least one of the fluid outlet line. Also, the cassette includes at least one mixing chamber within the housing. The mixing chamber is fluidly connected to the fluid outlet line.
  • [0006]
    Various embodiments of this aspect of the cassette include one or more of the following. Where the reciprocating pressure displacement pump includes a curved rigid chamber wall and a flexible membrane attached to the rigid chamber wall. The flexible membrane and the rigid chamber wall define a pumping chamber. Where the cassette housing includes a top plate, a midplate and a bottom plate. Where the cassette also includes at least one valve. In some embodiments, the at least one valve includes a valve housing having a membrane. The membrane divides the housing into two chambers. Where the mixing chamber includes a curved rigid chamber wall having at least one fluid inlet and at least one fluid outlet. Where the cassette also includes at least one metering membrane pump within the housing. The metering pump fluidly connects to the mixing chamber on the housing and to a metering pump fluid line. The metering pump fluid line is fluidly connected to the at least one of the at least one fluid inlet lines. Some embodiments of the metering pump include where the fluid line is connected to at second fluid inlet line.
  • [0007]
    In accordance with another aspect of the pump cassette the cassette includes a housing including at least two fluid inlet lines and at least one fluid outlet line. Also included is at least one reciprocating pressure displacement membrane pump within the housing. The pressure pump pumps a fluid from at least one of the fluid inlet line to at lease one of the fluid outlet line. The cassette also includes at least one mixing chamber within the housing, the mixing chamber fluidly connected to the fluid outlet line. Also included is at least one metering membrane pump within the housing. The metering membrane pump fluidly connects to the mixing chamber on the housing and to a metering pump fluid line. The metering pump fluid line is fluidly connected to the at least one of the at least two fluid inlet lines.
  • [0008]
    Various embodiments of this aspect, of the cassette include one or more of the following. Where the reciprocating pressure displacement pump includes a curved rigid chamber wall and a flexible membrane attached to the rigid chamber wall. The flexible membrane and the rigid chamber wall define a pumping chamber. Where the cassette housing includes a top plate, a midplate and a bottom plate. Where the mixing chamber includes a curved rigid chamber wall having at least one fluid inlet and at least one fluid outlet. Where the cassette further includes at least one valve. In some embodiments, the valve includes a valve housing having a membrane dividing the housing into two chambers.
  • [0009]
    In accordance with another aspect of the pump cassette includes a housing. The housing includes at least three fluid inlet lines and at least one fluid outlet line. The cassette also includes at least two reciprocating pressure displacement membrane pumps within the housing that pump a fluid from at least one of the fluid inlet lines to at lease one of the fluid outlet line. Also, the cassette includes at least one mixing chamber within the housing that is fluidly connected to the fluid outlet line. The cassette also includes at least two metering membrane pumps within the housing. The metering pumps are fluidly connected to respective fluid inlet lines and to the mixing chamber on the housing. The metering pumps pump a volume of a respective fluid from the fluid inlet lines to a fluid line fluidly connected to the mixing chamber.
  • [0010]
    Various embodiments of this aspect of the cassette include one or more of the following. Where the reciprocating pressure displacement pump includes a curved rigid chamber wall and a flexible membrane attached to the rigid chamber wall. The flexible membrane and the rigid chamber wall define a pumping chamber. Where the cassette housing includes a top plate, a midplate and a bottom plate. Where the cassette includes at least one valve. Some embodiments include where the valve includes a valve housing having a membrane, the membrane dividing the housing into two chambers.
  • [0011]
    These aspects of the invention are not meant to be exclusive and other features, aspects, and advantages of the present invention will be readily apparent to those of ordinary skill in the art when read in conjunction with the appended claims and accompanying drawings.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0012]
    These and other features and advantages of the present invention will be better understood by reading the following detailed description, taken together with the drawings wherein:
  • [0013]
    FIG. 1A is a sectional view of one embodiment of a pod-pump that is incorporated into embodiments of cassette;
  • [0014]
    FIG. 1B is a sectional view of an exemplary embodiment of a pod pump that is incorporated into embodiments of the cassette;
  • [0015]
    FIG. 2A is an illustrative sectional view of one embodiment of one type of pneumatically controlled valve that is incorporated into some embodiments of the cassette;
  • [0016]
    FIG. 2B is a sectional view of another embodiment of one type of pneumatically controlled valve that is incorporated into some embodiments of the cassette;
  • [0017]
    FIG. 2C is a sectional view of another embodiment of one type of pneumatically controlled valve that is incorporated into some embodiments of the cassette;
  • [0018]
    FIG. 2D is a sectional view of another embodiment of one type of pneumatically controlled valve that is incorporated into some embodiments of the cassette;
  • [0019]
    FIGS. 2E-2F are top and bottom views of embodiments of the valving membrane;
  • [0020]
    FIG. 2G shows pictorial, top and cross sectional views of one embodiment of the valving membrane;
  • [0021]
    FIG. 3 is a sectional view of a pod pump within a cassette;
  • [0022]
    FIG. 4 is a sectional view of a pod pump within a cassette having a variable membrane;
  • [0023]
    FIGS. 4A and 4B are top and section views respectively of a pod pump within a cassette having a dimpled/variable membrane;
  • [0024]
    FIGS. 4C and 4D are pictorial views of a single ring membrane with a variable surface;
  • [0025]
    FIGS. 5A-5D are side views of various embodiments of variable membranes;
  • [0026]
    FIGS. 5E-5H are pictorial views of various embodiments of the metering pump membrane;
  • [0027]
    FIGS. 6A and 6B are pictorial views of a double ring membrane with a smooth surface;
  • [0028]
    FIGS. 6C and 6D are pictorial views of a double ring membrane with a dimple surface;
  • [0029]
    FIGS. 6E and 6F are pictorial views of double ring membranes with variable surfaces;
  • [0030]
    FIG. 6G is a cross sectional view of a double ring membrane with a variable surface;
  • [0031]
    FIG. 7 is a schematic showing a pressure actuation system that may be used to actuate a pod pump;
  • [0032]
    FIG. 8 is one embodiment of the fluid flow-path schematic of the cassette;
  • [0033]
    FIG. 9 is an alternate embodiment fluid flow-path schematic for an alternate embodiment of the cassette;
  • [0034]
    FIG. 10 is an isometric front view of the exemplary embodiment of the actuation side of the midplate of the cassette with the valves indicated corresponding to FIG. 8;
  • [0035]
    FIG. 11A are front and isometric views of the exemplary embodiment of the outer top plate of the cassette;
  • [0036]
    FIG. 11B are front and isometric views of the exemplary embodiment of the inner top plate of the cassette;
  • [0037]
    FIG. 11C is a side view of the exemplary embodiment of the top plate of the cassette;
  • [0038]
    FIG. 12A are front and isometric views of the exemplary embodiment of the fluid side of the midplate of the cassette;
  • [0039]
    FIG. 12B are front and isometric views of the exemplary embodiment of the air side of the midplate of the cassette;
  • [0040]
    FIG. 12C is a side view of the exemplary embodiment of the midplate of the cassette;
  • [0041]
    FIG. 13A are front and isometric views of the exemplary embodiment of the inner side of the bottom plate of the cassette;
  • [0042]
    FIG. 13B are front and isometric views of the exemplary embodiment of the outer side of the bottom plate of the cassette;
  • [0043]
    FIG. 13C is a side view of the exemplary embodiment of the midplate of the cassette;
  • [0044]
    FIG. 14A is a top view of the assembled exemplary embodiment of the cassette;
  • [0045]
    FIG. 14B is a bottom view of the assembled exemplary embodiment of the cassette;
  • [0046]
    FIG. 14C is an exploded view of the assembled exemplary embodiment of the cassette;
  • [0047]
    FIG. 14D is an exploded view of the assembled exemplary embodiment of the cassette;
  • [0048]
    FIGS. 15A-15C show cross sectional views of the exemplary embodiment of the assembled cassette;
  • [0049]
    FIG. 16A show isometric and top views of an alternate embodiment of the top plate according to an alternate embodiment of the cassette;
  • [0050]
    FIG. 16B show bottom views of an alternate embodiment of the top plate according to an alternate embodiment of the cassette;
  • [0051]
    FIG. 16C shows a side view of the alternate embodiment of the top plate;
  • [0052]
    FIG. 17A show isometric and top views of an alternate embodiment of the midplate according to an alternate embodiment of the cassette;
  • [0053]
    FIG. 17B show isometric and bottom views of an alternate embodiment of the midplate according to an alternate embodiment of the cassette;
  • [0054]
    FIG. 17C shows a side view of the alternate embodiment of the midplate;
  • [0055]
    FIG. 18A show isometric and top views of an alternate embodiment of the bottom plate according to an alternate embodiment of the cassette;
  • [0056]
    FIG. 18B show isometric and bottom views of an alternate embodiment of the bottom according to an alternate embodiment of the cassette;
  • [0057]
    FIG. 18C shows a side view of the alternate embodiment of the bottom plate;
  • [0058]
    FIG. 19A is a top view of an assembled alternate embodiment of the cassette;
  • [0059]
    FIG. 19B is an exploded view of the assembled alternate embodiment of the cassette;
  • [0060]
    FIG. 19C is an exploded view of the assembled alternate embodiment of the cassette; and
  • [0061]
    FIGS. 20A-20B shows a cross sectional view of the exemplary embodiment of the assembled cassette.
  • DETAILED DESCRIPTION OF SPECIFIC EMBODIMENTS
  • [0000]
    • 1. Pumping Cassette
  • [0063]
    1.1 Cassette
  • [0064]
    The pumping cassette includes various features, namely, pod pumps, fluid lines and in some embodiment, valves. The cassette embodiments shown and described in this description include exemplary and some alternate embodiments. However, any variety of cassettes having a similar functionality is contemplated. As well, although the cassette embodiments described herein are implementations of the fluid schematics as shown in FIGS. 8A and 8B, in other embodiments, the cassette may have varying fluid paths and/or valve placement and/or pod pump placements and numbers and thus, is still within the scope of the invention.
  • [0065]
    In the exemplary embodiment, the cassette includes a top plate, a midplate and a bottom plate. There are a variety of embodiments for each plate. In general the top plate includes pump chambers and fluid lines, the midplate includes complementary fluid lines, metering pumps and valves and the bottom plate includes actuation chambers (and in some embodiments, the top plate and the bottom plate include complementary portions of a balancing chamber).
  • [0066]
    In general, the membranes are located between the midplate and the bottom plate, however, with respect to balancing chambers, a portion of a membrane is located between the midplate and the top plate. Some embodiments include where the membrane is attached to the cassette, either overmolded, captured, bonded, press fit, welded in or any other process or method for attachment, however, in the exemplary embodiments, the membranes are separate from the top plate, midplate and bottom plate until the plates are assembled.
  • [0067]
    The cassettes may be constructed of a variety of materials. Generally, in the various embodiment, the materials used are solid and nan flexible. In the preferred embodiment, the plates are constructed of polysulfone, but in other embodiments, the cassettes are constructed of any other solid material and in exemplary embodiment, of any thermoplastic or thermoset.
  • [0068]
    In the exemplary embodiment, the cassettes are formed by placing the membranes in their correct locations, assembling the plates in order and connecting the plates. In one embodiment, the plates are connected using a laser welding technique. However, in other embodiments, the plates may be glued, mechanically fastened, strapped together, ultrasonically welded or any other mode of attaching the plates together.
  • [0069]
    In practice, the cassette may be used to pump any type of fluid from any source to any location. The types of fluid include nutritive, nonnutritive, inorganic chemicals, organic chemicals, bodily fluids or any other type of fluid. Additionally, fluid in some embodiments include a gas, thus, in some embodiments, the cassette is used to pump a gas.
  • [0070]
    The cassette serves to pump and direct the fluid from and to the desired locations. In some embodiments, outside pumps pump the fluid into the cassette and the cassette pumps the fluid out. However, in some embodiments, the pod pumps serve to pull the fluid into the cassette and pump the fluid out of the cassette.
  • [0071]
    As discussed above, depending on the valve locations, control of the fluid paths is imparted. Thus, the valves being in different locations or additional valves are alternate embodiments of this cassette. Additionally, the fluid lines and paths shown in the figures described above are mere examples of fluid lines and paths. Other embodiments may have more, less and/or different fluid paths. In still other embodiments, valves are not present in the cassette.
  • [0072]
    The number of pod pumps described above may also vary depending on the embodiment. For example, although the exemplary and alternate embodiments shown and described above include two pod pumps, in other embodiments, the cassette includes one. In still other embodiments, the cassette includes more than two pod pumps. The pod pumps can be single pumps or work in tandem to provide a more continuous flow. Either or both may be used in various embodiments of the cassette.
  • [0073]
    The various fluid inlets and fluid outlets are fluid ports. In practice, depending on the valve arrangement and control, a fluid inlet can be a fluid outlet. Thus, the designation of the fluid port as a fluid inlet or a fluid outlet is only for description purposes. The various embodiments have interchangeable fluid ports. The fluid ports are provided to impart particular fluid paths onto the cassette. These fluid ports are not necessarily all used all of the time; instead, the variety of fluid ports provides flexibility of use of the cassette in practice.
  • [0074]
    1.2 Exemplary Pressure Pod Pump Embodiments
  • [0075]
    FIG. 1A is a sectional view of an exemplary pod pump 100 that is incorporated into a fluid control or pump cassette (see also FIGS. 3 and 4), in accordance with an exemplary embodiment of the cassette. In this embodiment, the pod pump is formed from three rigid pieces, namely a “top” plate 106, a midplate 108, and a “bottom” plate 110 (it should be noted that the terms “top” and “bottom” are relative and are used here for convenience with reference to the orientation shown in FIG. 1A). The top and bottom plates 106 and 110 include generally hemispheroid portions that when assembled together define a hemispheroid chamber, which is a pod pump 100.
  • [0076]
    A membrane 112 separates the central cavity of the pod pump into two chambers. In one embodiment, these chambers are: the pumping chamber that receives the fluid to be pumped and an actuation chamber for receiving the control gas that pneumatically actuates the pump. An inlet 102 allows fluid to enter the pumping chamber, and an outlet 104 allows fluid to exit the pumping chamber. The inlet 102 and the outlet 104 may be formed between midplate 108 and the top plate 106. Pneumatic pressure is provided through a pneumatic port 114 to either force, with positive gas pressure, the membrane 112 against one wall of the pod pump cavity to minimize the pumping chamber's volume, or to draw, with negative gas pressure, the membrane 112 towards the other wail of the pod pump 100 cavity to maximize the pumping chamber's volume.
  • [0077]
    The membrane 112 is provided with a thickened rim 116, which is held tightly by a protrusion 118 in the midplate 108. Thus, in manufacturing, the membrane 112 can be placed in and held by the groove 108 before the bottom plate 110 is connected (in the exemplary embodiment) to the midplate 108.
  • [0078]
    Although not shown in FIGS. 1A and 1B, in some embodiments of the pod pump, on the fluid side, a groove is present on the chamber wall. The groove acts to prevent folds in the membrane from trapping fluid in the chamber when emptying.
  • [0079]
    Referring first to FIG. 1A a cross sectional view of a reciprocating positive-displacement pump 100 in a cassette is shown. The pod pump 100 includes a flexible membrane 112 (also referred to as the “pump diaphragm” or “membrane”) mounted where the pumping chamber (also referred to as a “liquid chamber” or “liquid pumping chamber”) wall 122 and the actuation chamber (also referred to as the “pneumatic chamber”) wall 120 meet. The membrane 112 effectively divides that interior cavity into a variable-volume pumping chamber (defined by the rigid interior surface of the pumping chamber wall 122 and a surface of the membrane 112) and a complementary variable-volume actuation chamber (defined by the rigid interior surface of the actuation chamber wall 120 and a surface of the membrane 112). The top portion 106 includes a fluid inlet 102 and a fluid outlet 104, both of which are in fluid communication with the pumping/liquid chamber. The bottom portion 110 includes an actuation or pneumatic interface 114 in fluid communication with the actuation chamber. As discussed in greater detail below, the membrane 112 can be urged to move back and forth within the cavity by alternately applying negative or vent to atmosphere and positive pneumatic pressure at the pneumatic interface 114. As the membrane 112 reciprocates back and forth, the sum of the volumes of the pumping and actuation chambers remains constant.
  • [0080]
    During typical fluid pumping operations, the application of negative or vent to atmosphere pneumatic pressure to the actuation or pneumatic interface 114 tends to withdraw the membrane 112 toward the actuation chamber wall 120 so as to expand the pumping/liquid chamber and draw fluid into the pumping chamber through the inlet 102, while the application of positive pneumatic pressure tends to push the membrane 112 toward the pumping chamber wall 122 so as to collapse the pumping chamber and expel fluid in the pumping chamber through the outlet 104. During such pumping operations, the interior surfaces of the pumping chamber wall 122 and the actuation chamber wall 120 limit movement of the membrane 112 as it reciprocates back and forth. In the embodiment shown in FIG. 1A, the interior surfaces of the pumping chamber wall 122 and the actuation chamber wall 120 are rigid, smooth, and hemispherical. In lieu of a rigid actuation chamber wall 120, an alternative rigid limit structure—for example, a portion of a bezel used for providing pneumatic pressure and/or a set of ribs—may be used to limit the movement of the membrane as the pumping chamber approaches maximum value. Bezels and rib structures are described generally in U.S. patent application Ser. No. 10/697,450 entitled BEZEL ASSEMBLY FOR PNEUMATIC CONTROL filed on Oct. 30, 2003 and published as Publication No. U.S. 2005/0095154 (Attorney Docket No. 1062/D75) and related PCT Application No. PCT/US2004/035952 entitled BEZEL ASSEMBLY FOR PNEUMATIC CONTROL filed on Oct. 29, 2004 and published as Publication No. WO 2005/044435 (Attorney Docket No. 1062/D71WO), both of which are hereby incorporated herein by reference in their entireties. Thus, the rigid limit structure—such as the rigid actuation chamber wall 120, a bezel, or a set of ribs—defines the shape of the membrane 112 when the pumping chamber is at its maximum value. In a preferred embodiment, the membrane 112 (when urged against the rigid limit structure) and the rigid interior surface of the pumping chamber wall 122 define a spherical pumping chamber volume when the pumping chamber volume is at a minimum.
  • [0081]
    Thus, in the embodiment shown in FIG. 1A, movement of the membrane 112 is limited by the pumping chamber wall 122 and the actuation chamber wall 120. As long as the positive and vent to atmosphere or negative pressurizations provided through the pneumatic port 114 are strong enough, the membrane 112 will move from a position limited by the actuation chamber wall 120 to a position limited by the pumping chamber wall 122. When the membrane 112 is forced against the actuation chamber wall 120, the membrane and the pumping chamber wall 122 define the maximum volume of the pumping chamber. When the membrane is forced against the pumping chamber wall 122, the pumping chamber is at its minimum volume.
  • [0082]
    In an exemplary embodiment, the pumping chamber wall 122 and the actuation chamber wall 120 both have a hemispheroid shape so that the pumping chamber will have a spheroid shape when it is at its maximum volume. By using a pumping chamber that attains a spheroid shape—and particularly a spherical shape—at maximum volume, circulating flow may be attained throughout the pumping chamber. Such shapes accordingly tend to avoid stagnant pockets of fluid in the pumping chamber. As discussed further below, the orientations of the inlet 102 and outlet 104 also tend to have an impact on the flow of fluid through the pumping chamber and in some embodiments, reduce the likelihood of stagnant pockets of fluid forming. Additionally, compared to other volumetric shapes, the spherical shape (and spheroid shapes in general) tends to create less shear and turbulence as the fluid circulates into, through, and out of the pumping chamber.
  • [0083]
    Referring now to FIGS. 3-4, a raised flow path 30 is shown in the pumping chamber. This raised flow path 30 allows for the fluid to continue flowing through the pod pumps after the membrane reaches the end of stroke. Thus, the raised flow path 30 minimizes the chances of the membrane causing air or fluid to be trapped in the pod pump or the membrane blocking the inlet or outlet of the pod pump which would inhibit continuous flow. The raised flow path 30 is shown in the exemplary embodiment having particular dimensions, however, in alternate embodiments, as seen in FIGS. 18A-18E, the raised flow path 30 is narrower, or in still other embodiments, the raised flow path 30 can be any dimensions as the purpose is to control fluid flow so as to achieve a desired flow rate or behavior of the fluid. Thus, the dimensions shown and described here with respect to the raised flow path, the pod pumps, the valves or any other aspect are mere exemplary and alternate embodiments. Other embodiments are readily apparent.
  • [0084]
    1.3 Exemplary Balancing Pods Embodiment
  • [0085]
    Referring now to FIG. 1B, an exemplary embodiment of a balancing pod is shown. The balancing pod is constructed similar to the pod pump described above with respect to FIG. 1A. However, a balancing pod includes two fluid balancing chambers, rather than an actuation chamber and a pumping chamber, and does not include an actuation port. Additionally, each balancing chamber includes an inlet 102 and an outlet 104. In the exemplary embodiment, a groove 126 is included on each of the balancing chamber walls 120, 122. The groove 126 is described in further detail below.
  • [0086]
    The membrane 112 provides a seal between the two chambers. The balancing chambers work to balance the flow of fluid into and out of the chambers such that both chambers maintain an equal volume rate flow. Although the inlets 102 and outlets 104 for each chamber are shown to be on the same side, in other embodiments, the inlets 102 and outlets 104 for each chamber are on different sides. Also, the inlets 102 and outlets 104 can be on either side, depending on the flow path in which the balancing chamber is integrated.
  • [0087]
    In one embodiment of the balancing chambers the membrane 112 includes an embodiment similar to the one described below with respect to FIG. 6A-6G. However, in alternate embodiments, the membrane 112 can be over molded or otherwise constructed such that a double-ring seal is not applicable.
  • [0088]
    1.4 Metering Pumps and Fluid Management System
  • [0089]
    The metering pump can he any pump that is capable of adding any fluid or removing any fluid. The fluids include but are not limited to pharmaceuticals, inorganic compounds or elements, organic compounds or elements, nutraceuticals, nutritional elements or compounds or solutions, or any other fluid capable of being pumped. In one embodiment, the metering pump is a membrane pump. In the exemplary embodiment, the metering pump is a smaller volume pod pump. In the exemplary embodiment, the metering pump includes an inlet and an outlet, similar to a larger pod pump (as shown in FIG. 1A for example). However, the inlet and outlet are generally much smaller than a pod pump and, in one exemplary embodiment, includes a volcano valve-like raised ring around either the inlet or outlet. Metering pumps include a membrane, and various embodiments of a metering pump membrane are shown in FIGS. 5E-5H. The metering pump, in some embodiments, pumps a volume of fluid out of the fluid line. Once the fluid is in the pod pump, a reference chamber, located outside the cassette, using the FMS, determines the volume that has been removed.
  • [0090]
    Thus, depending on the embodiment, this volume of fluid that has been removed will not then flow to the fluid outlet, the balance chambers or to a pod pump. Thus, in some embodiments, the metering pump is used to remove a volume of fluid from a fluid line. In other embodiments, the metering pump is used to remove a volume of fluid to produce other results.
  • [0091]
    FMS may be used to perform certain fluid management system measurements, such as, for example, measuring the volume of subject fluid pumped through the pump chamber during a stroke of the membrane or detecting air in the pumping chamber, e.g., using techniques described in U.S. Pat. Nos. 4,808,161; 4,826,482; 4,976,162; 5,088,515; and 5,350,357, which are hereby incorporated herein by reference in their entireties.
  • [0092]
    Metering pumps are also used in various embodiments to pump a second fluid info the fluid line, in some embodiments, the metering pump is used to pump a therapeutic or a compound into a fluid line. One embodiment uses the metering pump to pump a volume of compound into a mixing chamber in order to constitute a solution. In some of these embodiments, the metering pumps are configured for FMS volume measurement. In other embodiments, the metering pumps are not.
  • [0093]
    For FMS measurement, a small fixed reference air chamber is located outside of the cassette, for example, in the pneumatic manifold (not shown). A valve isolates the reference chamber and a second pressure sensor. The stroke volume of the metering pump may be precisely computed by charging the reference chamber with air, measuring the pressure, and then opening the valve to the pumping chamber. The volume of air on the chamber side may be computed based on the fixed volume of the reference chamber and the change in pressure when the reference chamber was connected to the pump chamber.
  • [0094]
    1.5 Valves
  • [0095]
    The exemplary embodiment of the cassette includes one or more valves. Valves are used to regulate flow by opening and closing fluid lines. The valves included in the various embodiments of the cassette include one or more of the following: volcano valves or smooth valves. In some embodiment of the cassette, check valves may be included Embodiments of the volcano valve are shown in FIGS. 2A and 2B, while an embodiment of the smooth valve is shown in FIG. 2C. Additionally, FIGS. 3 and 4 show cross sections of one embodiment of a pod pump in a cassette with an inlet and an outlet valve.
  • [0096]
    Generally speaking, reciprocating positive-displacement pumps of the types just described may include, or may be used in conjunction with, various valves to control fluid flow through the pump. Thus, for example, the reciprocating positive-displacement pump or the balancing pods may include, or be used in conjunction with, an inlet valve and/or an outlet valve. The valves may be passive or active. In the exemplary embodiment of the reciprocating positive-displacement pump the membrane is urged back and forth by positive and negative pressurizations, or by positive and vent to atmosphere pressurizations, of a gas provided through the pneumatic port, which connects the actuation chamber to a pressure actuation system. The resulting reciprocating action of the membrane pulls fluid into the pumping chamber from the inlet (the outlet valve prevents liquid from being sucked back into the pumping chamber from the outlet) and then pushes the fluid out of the pumping chamber through the outlet (the inlet valve prevents fluid from being forced back from the inlet).
  • [0097]
    In the exemplary embodiments, active valves control the fluid flow through the pump(s) and the cassette. The active valves may be actuated by a controller in such a manner as to direct flow in a desired direction. Such an arrangement would generally permit the controller to cause flow in either direction through the pod pump. In a typical system, the flow would normally be in a first direction, e.g., from the inlet, to the outlet. At certain other times, the flow may be directed in the opposite direction, e.g., from the outlet to the inlet. Such reversal of flow may be employed, for example, during priming of the pump, to check for an aberrant line condition (e.g., a line occlusion, blockage, disconnect, or leak), or to clear an aberrant line condition (e.g., to try to dislodge a blockage).
  • [0098]
    Pneumatic actuation of valves provides pressure control and a natural limit to the maximum pressure that may be developed in a system. In the context of a system, pneumatic actuation has the added benefit of providing the opportunity to locate all the solenoid control valves on one side of the system away from the fluid paths.
  • [0099]
    Referring now to FIGS. 2A and 2B, sectional views of two embodiments of a volcano valve are shown. The volcano valves are pneumatically controlled valves that may be used in embodiments of the cassette. A membrane 202, along with the midplate 204, defines a valving chamber 206. Pneumatic pressure is provided through a pneumatic port 208 to either force, with positive gas pressure, the membrane 202 against a valve seat 210 to close the valve, or to draw, with negative gas pressure, or in some embodiments, with vent to atmospheric pressure, the membrane away from the valve seat 210 to open the valve. A control gas chamber 212 is defined by the membrane 202, the top plate 214, and the midplate 204. The midplate 204 has an indentation formed on it, into which the membrane 202 is placed so as to form the control gas chamber 212 on one side of the membrane 202 and the valving chamber 206 on the other side.
  • [0100]
    The pneumatic port 208 is defined by a channel formed in the top plate 214. By providing pneumatic control of several valves in a cassette, valves can be ganged together so that all the valves ganged together can be opened or closed at the same time by a single source of pneumatic pressure. Channels formed on the midplate 204, corresponding with fluid paths along with the bottom plate 216, define the valve inlet 218 and the valve outlet 220. Holes formed through the midplate 204 provide communication between the inlet 218 and the valving chamber 206 and between the valving chamber 206 and the outlet 220.
  • [0101]
    The membrane 202 is provided with a thickened rim 222, which fits tightly in a groove 224 in the midplate 204. Thus, the membrane 202 can be placed in and held by the groove 224 before the top plate 214 is connected to the midplate 204. Thus, this valve design may impart benefits in manufacturing. As shown in FIGS. 2B and 2C, the top plate 214 may include additional material extending into control gas chamber 212 so as to prevent the membrane 202 from being urged too much in a direction away from the groove 224, so as to prevent the membrane's thickened rim 222 from popping out of the groove 224. The location of the pneumatic port 208 with respect to the control gas chamber 212 varies in the two embodiments shown in FIGS. 2A and 2B.
  • [0102]
    FIG. 2C shows an embodiment in which the valving chamber lacks a valve seat feature. Rather, in FIG. 2C, the valve in this embodiment does not include any volcano features and thus, the valving chamber 206, i.e., the fluid side, does not include any raised features and thus is smooth. This embodiment is used in cassettes used to pump fluid sensitive to shearing. FIG. 2D shows an embodiment in which the valving chamber has a raised area to aid in the sealing of the valving membrane. Referring now to FIGS. 2E-2G, various embodiments of the valve membrane are shown. Although some exemplary embodiments have been shown and described, in other embodiments, variations of the valve and valving membrane may be used.
  • [0103]
    1.6 Exemplary Embodiments of the Pod Membrane
  • [0104]
    In some embodiments, the membrane has a variable cross-sectional thickness, as shown in FIG. 4. Thinner, thicker or variable thickness membranes may be used to accommodate the strength, flexural and other properties of the chosen membranes materials. Thinner, thicker or variable membrane wall thickness may also be used to manage the membrane thereby encouraging it to flex more easily in some areas than in other areas, thereby aiding in the management of pumping action and flow of subject fluid in the pump chamber. In this embodiment the membrane is shown having its thickest cross-sectional area closest to its center. However in other embodiments having a membrane with a varying cross-sectional, the thickest and thinnest areas may be in any location on the membrane. Thus, for example, the thinner cross-section may be located near the center and the thicker cross-sections located closer to the perimeter of the membrane. Still other configurations are possible. Referring to FIGS. 5A-5D, one embodiment of a membrane is shown having various surface embodiments, these include smooth (FIG. 5A), rings (FIG. 5D), ribs (FIG. 5C), dimples or dots (FIG. 5B) of variable thickness and or geometry located at various locations on the actuation and or pumping side of the membrane. In one embodiment of the membrane, the membrane has a tangential slope in at least one section, but in other embodiments, the membrane is completely smooth or substantially smooth.
  • [0105]
    Referring now to FIGS. 4A, 4C and 4D, an alternate embodiment of the membrane is shown. In this embodiment, the membrane has a dimpled or dotted surface.
  • [0106]
    The membrane may be made of any flexible material having a desired durability and compatibility with the subject fluid. The membrane can be made from any material that may ilex in response to fluid, liquid or gas pressure or vacuum applied to the actuation chamber. The membrane material may also be chosen for particular bio-compatibility, temperature compatibility or compatibility with various subject fluids that may be pumped by the membrane or introduced to the chambers to facilitate movement of the membrane. In the exemplary embodiment, the membrane is made from high elongation silicone. However, in other embodiments, the membrane is made from any elastomer or rubber, including, but not limited to, silicone, urethane, nitrile, EPDM or any other rubber, elastomer or flexible material.
  • [0107]
    The shape of the membrane is dependent on multiple variables. These variables include, but are not limited to; the shape of the chamber; the size of the chamber; the subject fluid characteristics; the volume of subject fluid pumped per stroke; and the means or mode of attachment of the membrane to the housing. The size of the membrane is dependent on multiple variables. These variables include, but are not limited to: the shape of the chamber; the size of the chamber; the subject fluid characteristics; the volume of subject fluid pumped per stroke; and the means or mode of attachment of the membrane to the housing. Thus, depending on these or other variables, the shape and size of the membrane may vary in various embodiments.
  • [0108]
    The membrane can have any thickness. However, in some embodiments, the range of thickness is between 0.002 inches to 0.125 inches. Depending on the material used for the membrane, the desired thickness may vary. In one embodiment, high elongation silicone is used in a thickness ranging from 0.015 inches to 0.050 inches. However in other embodiments, the thickness may vary.
  • [0109]
    In the exemplary embodiment, the membrane is pre-formed to include a substantially dome-shape in at least part of the area of the membrane. One embodiment of the dome-shaped membrane is shown in FIGS. 4E and 4F. Again, the dimensions of the dome may vary based on some or more of the variables described above. However, in other embodiments, the membrane may not include a pre-formed dome shape.
  • [0110]
    In the exemplary embodiment, the membrane dome is formed using liquid injection molding. However, in other embodiments, the dome may be formed by using compression molding. In alternate embodiments, the membrane is substantially flat. In other embodiments, the dome size, width or height may vary.
  • [0111]
    In various embodiments, the membrane may be held in place by various means and methods. In one embodiment, the membrane is clamped between the portions of the cassette, and in some of these embodiments, the rim of the cassette may include features to grab the membrane. In others of this embodiment, the membrane is clamped to the cassette using at least one bolt or another device. In another embodiment, the membrane is over-molded with a piece of plastic and then the plastic is welded or otherwise attached to the cassette. In another embodiment, the membrane is pinched between the mid plate described with respect to FIGS. 1A and 1B and the bottom plate. Although some embodiments for attachment of the membrane to the cassette are described, any method or means for attaching the membrane to the cassette can be used. The membrane, in one alternate embodiment, is attached directly to one portion of the cassette. In some embodiments, the membrane is thicker at the edge, where the membrane is pinched by the plates, than in other areas of the membrane. In some embodiments, this thicker area is a gasket, in some embodiments an O-ring, ring or any other shaped gasket. Referring again to 6A-6D, one embodiment of the membrane is shown with two gaskets 62, 64. In some of these embodiments, the gasket(s) 62, 64 provides the attachment, point of the membrane to the cassette. In other embodiments, the membrane includes more than two gaskets. Membranes with one gasket are also included in some embodiments (see FIGS. 4A-4D).
  • [0112]
    In some embodiments of the gasket, the gasket is contiguous with the membrane. However, in other embodiments, the gasket is a separate part of the membrane. In some embodiments, the gasket is made from the same material as the membrane. However, in other embodiments, the gasket is made of a material different from the membrane. In some embodiments, the gasket, is formed by over-molding a ring around the membrane. The gasket can be any shape ring or seal desired so as to complement the pod pump housing embodiment. In some embodiments, the gasket is a compression type gasket.
  • [0113]
    1.7 Mixing Pods
  • [0114]
    Some embodiments of the cassette include a mixing pod. A mixing pod includes a chamber for mixing. In some embodiments, the mixing pod is a flexible structure, and in some embodiments, at least a section of the mixing pod is a flexible structure. The mixing pod can include a seal, such as an o-ring, or a membrane. The mixing pod can be any shape desired, in the exemplary embodiment, the mixing pod is similar to a pod pump except it does not include a membrane and does not include an actuation port. Some embodiments of this embodiment of the mixing pod include an o-ring seal to seal the mixing pod chamber. Thus, in the exemplary embodiment, the mixing pod is a spherical hollow pod with a fluid inlet and a fluid outlet. As with the pod pumps, the chamber size can be any size desired.
    • 2. Pressure Pump Actuation System
  • [0116]
    FIG. 7 is a schematic showing an embodiment of a pressure actuation system that may be used to actuate a pod pump with both positive and negative pressure, such as the pod pump shown in FIG. 1A. The pressure actuation system is capable of intermittently or alternately providing positive and negative pressurizations to the gas in the actuation chamber of the pod pump. However, in some embodiments, FIG. 7 does not apply in these embodiments, actuation of the pod pump is accomplished by applying positive pressure and vent to atmosphere (again, not shown in FIG. 7). The pod pump—including the flexible membrane, the inlet, the outlet, the pneumatic port, the pumping chamber, the actuation chamber, and possibly including an inlet check valve and an outlet check valve or other valves—is part of a larger disposable system. The pneumatic actuation system—including an actuation-chamber pressure transducer, a positive-supply valve, a negative-supply valve, a positive-pressure gas reservoir, a negative-pressure gas reservoir, a positive-pressure-reservoir pressure transducer, a negative-pressure-reservoir pressure transducer, as well as an electronic controller including, in some embodiments, a user interface console (such as a touch-panel screen)—may be part of a base unit.
  • [0117]
    The positive-pressure reservoir provides to the actuation chamber the positive pressurization of a control gas to urge the membrane towards a position where the pumping chamber is at its minimum volume (i.e., the position where the membrane is against the rigid pumping-chamber wall). The negative-pressure reservoir provides to the actuation chamber the negative pressurization of the control gas to urge the membrane in the opposite direction, towards a position where the pumping chamber is at its maximum volume (i.e., the position where the membrane is against the rigid actuation-chamber wall).
  • [0118]
    A valving mechanism is used to control fluid communication between each of these reservoirs and the actuation chamber. As shown in FIG. 7, a separate valve is used for each of the reservoirs; a positive-supply valve controls fluid communication between the positive-pressure reservoir and the actuation chamber, and a negative-supply valve controls fluid communication between the negative-pressure reservoir and the actuation chamber. These two valves are controlled by the controller. Alternatively, a single three-way valve may be used in lieu of the two separate valves. The valves may be binary on-off valves or variable-restriction valves.
  • [0119]
    The controller also receives pressure information from the three pressure transducers: an actuation-chamber pressure transducer, a positive-pressure-reservoir pressure transducer, and a negative-pressure-reservoir pressure transducer. As their names suggest, these transducers respectively measure the pressure in the actuation chamber, the positive-pressure reservoir, and the negative-pressure reservoir. The actuation-chamber-pressure transducer is located in a base unit but is in fluid communication with the actuation chamber through the pod pump pneumatic port. The controller monitors the pressure in the two reservoirs to ensure they are properly pressurized (either positively or negatively). In one exemplary embodiment, the positive-pressure reservoir may be maintained at around 750 mmHG, while the negative-pressure reservoir may be maintained at around −450 mmHG.
  • [0120]
    Still referring to FIG. 7, a compressor-type pump or pumps (not shown) may be used to maintain the desired pressures in these reservoirs. For example, two independent compressors may be used to respectively service the reservoirs. Pressure in the reservoirs may be managed using a simple bang-bang control technique in which the compressor servicing the positive-pressure reservoir is turned on if the pressure in the reservoir falls below a predetermined threshold and the compressor servicing the negative-pressure reservoir is turned on if the pressure in the reservoir is above a predetermined threshold. The amount of hysteresis may be the same for both reservoirs or may be different. Tighter control of the pressure in the reservoirs can be achieved by reducing the size of the hysteresis band, although this will generally result in higher cycling frequencies of the compressors. If very tight control of the reservoir pressures is required or otherwise desirable for a particular application, the bang-bang technique could be replaced with a PID control technique and could use PWM signals on the compressors.
  • [0121]
    The pressure provided by the positive-pressure reservoir is preferably strong enough—under normal conditions—to urge the membrane all the way against the rigid pumping-chamber wall. Similarly, the negative pressure (i.e., the vacuum) provided by the negative-pressure reservoir is preferably strong enough—under normal conditions—to urge the membrane all the way against the actuation-chamber wall. In a further preferred embodiment, however, these positive and negative pressures provided by the reservoirs are within safe enough limits that even with either the positive-supply valve or the negative-supply valve open all the way, the positive or negative pressure applied against the membrane is not so strong as to damage the pod pump or create unsafe fluid pressures (e.g., that may harm a patient receiving pumped blood or other fluid).
  • [0122]
    It will be appreciated that other types of actuation systems may be used to move the membrane back and forth instead of the two-reservoir pneumatic actuation system shown in FIG. 7, although a two-reservoir pneumatic actuation system is generally preferred. For example, alternative pneumatic actuation systems may include either a single positive-pressure reservoir or a single negative-pressure reservoir along with a single supply valve and a single tank pressure sensor, particularly in combination with a resilient membrane. Such pneumatic actuation systems may intermittently provide either a positive gas pressure or a negative gas pressure to the actuation chamber of the pod pump. In embodiments having a single positive-pressure reservoir, the pump may be operated by intermittently providing positive gas pressure to the actuation chamber, causing the membrane to move toward the pumping chamber wall and expel the contents of the pumping chamber, and releasing the gas pressure, causing the membrane to return to its relaxed position and draw fluid into the pumping chamber. In embodiments having a single negative-pressure reservoir, the pump may be operated by intermittently providing negative gas pressure to the actuation chamber, causing the membrane to move toward the actuation chamber wall and draw fluid into the pumping chamber, and releasing the gas pressure, causing the membrane to return to its relaxed position and expel fluid from the pumping chamber.
    • 3. Fluid Handling
  • [0124]
    As shown and described with respect to FIGS. 2A-2D, a fluid valve in the exemplary embodiment consists of a small chamber with a flexible membrane or membrane across the center dividing the chamber into a fluid half and a pneumatic half. The fluid valve, in the exemplary embodiment, has 3 entry/exit ports, two on the fluid half of the chamber and one the pneumatic half of the chamber. The port on the pneumatic half of the chamber can supply either positive pressure or vacuum (or rather than vacuum, in some embodiments, there is a vent to atmosphere) to the chamber. When a vacuum is applied to the pneumatic portion of the chamber, the membrane is pulled towards the pneumatic side of the chamber, clearing the fluid path and allowing fluid to flow into and out of the fluid side of the chamber. When positive pressure is applied to the pneumatic portion of the chamber, the membrane is pushed towards the fluid side of the chamber, blocking the fluid path and preventing fluid flow. In the volcano valve embodiment (as shown in FIGS. 2A-2B) on one of the fluid ports, that port seals off first when closing the valve and the remainder of any fluid in the valve is expelled through the port without the volcano feature. Additionally, in one embodiment of the valves, shown in FIG. 2D, the raised feature between the two ports allows for the membrane to seal the two ports from each other earlier in the actuation stroke (i.e., before the membrane seals the ports directly).
  • [0125]
    Referring again to FIG. 7, pressure valves are used to operate the pumps located at different points in the flow path. This architecture supports pressure control by using two variable-orifice valves and a pressure sensor at each pump chamber which requires pressure control. In one embodiment, one valve is connected to a high-pressure source and the other valve is connected to a low-pressure sink. A high-speed control loop monitors the pressure sensor and controls the valve positions to maintain the necessary pressure in the pump chamber.
  • [0126]
    Pressure sensors are used to monitor pressure in the pneumatic portion of the chambers themselves. By alternating between positive pressure and vacuum on the pneumatic side of the chamber, the membrane is cycled back and forth across the total chamber volume. With each cycle, fluid is drawn through the upstream valve of the inlet fluid port when the pneumatics pull a vacuum on the pods. The fluid is then subsequently expelled through the outlet port and the downstream valve when the pneumatics deliver positive pressure to the pods.
  • [0127]
    In many embodiments pressure pumps consist of a pair of chambers. When the two chambers are run 180 degrees out of phase from one another the flow is essentially continuous.
    • 4. Volume Measurement
  • [0129]
    These flow rates in the cassette are controlled using pressure pod pumps which can defect end-of-stroke. An outer control loop determines the correct pressure values to deliver the required flow. Pressure pumps can run an end of stroke algorithm to detect when each stroke completes. While the membrane is moving, the measured pressure in the chamber tracks a desired sinusoidal pressure. When the membrane contacts a chamber wall, the pressure becomes constant, no longer tracking the sinusoid. This change in the pressure signal is used to detect when the stroke has ended, i.e., the end of stroke.
  • [0130]
    The pressure pumps have a known volume. Thus, an end of stroke indicates a known volume of fluid is in the chamber. Thus, using the end-of-stroke, fluid flow may be controlled using rate equating to volume.
  • [0131]
    As described above in more detail, FMS may be used to determine the volume of fluid pumped by the metering pumps. In some embodiments, the metering pump may pump fluid without using the FMS volume measurement system, however, in the exemplary embodiments, the FMS volume measurement system is used to calculate the exact volume of fluid pumped.
    • 5. Exemplary Embodiment of the Pumping Cassette
  • [0133]
    The terms inlet and outlet as well as first fluid, second fluid, third fluid, and the number designations given to valving paths (i.e. “first valving path”) are used for description purposes only. In other embodiments, an inlet can be an outlet, as well, an indication of a first, second, third fluid does not denote that they are different fluids or are in a particular hierarchy. The denotations simply refer to separate entrance areas into the cassette and the first, second, third, etc, fluids may be different fluids or the same fluid types or composition or two or more may be the same. Likewise, the designation of the first, second, third, etc. valving paths do not have any particular meaning, but are used for clearness of description.
  • [0134]
    The designations given for the fluid inlets (which can also be fluid outlets), for example, first, fluid outlet, second fluid outlet, merely indicate that a fluid may travel out of or into the cassette via that inlet/outlet. In some cases, more than one inlet/outlet on the schematic is designated with an identical name. This merely describes that all of the inlet/outlets having that designation are pumped by the same metering pump or set of pod pumps (which in alternate embodiments, can be a single pod pump).
  • [0135]
    Referring now to FIG. 8, an exemplary embodiment of the fluid schematic of the cassette 800 is shown. Other schematics are readily discernable. The cassette 800 includes at least one pod pump 828, 820 and at least one mixing chamber 818. The cassette 800 also includes a first fluid inlet 810, where a first fluid enters the cassette. The first fluid includes a flow rate provided by one of the at least one pod pump 820, 828 in the cassette 800. The cassette 800 also includes a first fluid outlet 824 where fluid exits the cassette 800 having a flow rate provided by one of the at least one pod pump 820, 828. The cassette 800 includes at least one metering fluid line 812, 814, 816 that is in fluid connection with the first fluid outlet. The cassette also includes at least one second fluid inlet 826 where the second fluid enters the cassette 800. In some embodiments of the cassette 800 a third fluid inlet 825 is also included.
  • [0136]
    Metering pumps 822, 830 pump the second fluid and the third fluid into the first fluid outlet line. The second fluid and, in some embodiments, the third fluid, connected to the cassette 800 at the second fluid inlet 826 and third fluid inlet 825 respectively, are each fluidly connected to a metering pump 822, 830 and to the first fluid outlet line through a metering fluid line 812, 814, 816. The metering pumps 822, 830, described in more detail below, in the exemplary embodiment, include a volume measurement capacity such that the volume of fluid pumped by the metering pumps 822, 830 is readily discernible.
  • [0137]
    The mixing chamber 818 is connected to the first fluid outlet line 824 and includes a fluid inlet and a fluid outlet. In some embodiments, sensors are located upstream and downstream from the mixing chamber 818. The location of the sensors in the exemplary embodiment are shown and described below with respect to FIGS. 14C, 14D and FIGS. 15B and 15C.
  • [0138]
    The cassette 800 is capable of internally mixing a solution made up of at least two components. The cassette 800 also includes the capability of constituting a powder to a fluid prior to pumping the fluid into the mixing chamber. These capabilities will be described in greater detail below.
  • [0139]
    Various valves 832-860 impart the various capabilities of the cassette 800. The components of the cassette 800 may be used differently in the different embodiments based on various valving controls.
  • [0140]
    The fluid schematic of the cassette 800 shown in FIG. 8 may be embodied into various cassette apparatus. Thus, the embodiments of the cassette 800 including the fluid schematic shown in FIG. 8 are not the only cassette embodiments that may incorporate this or an alternate embodiment of this fluid schematic. Additionally, the types of valves, the ganging of the valves, the number of pumps and chambers may vary in various cassette embodiments of this fluid schematic.
  • [0141]
    Referring now to FIG. 8, a fluid flow-path schematic 800 is shown with the fluid paths indicated based on different valving flow paths. The fluid flow-path schematic 800 is described herein corresponding to the valving flow paths in one embodiment of the cassette. The exemplary embodiment of the midplate 900 of the cassette are shown in FIG. 10 with the valves indicated corresponding to the respective fluid flow-path schematic 800 in FIG. 8. For the purposes of the description, the fluid flow paths will be described based on the valving. The term “valving path” refers to a fluid path that may, in some embodiments, be available based on the control of particular valves. The corresponding fluid side structures of FIG. 10 are shown in FIG. 12A.
  • [0142]
    Referring now to FIGS. 8 and 10 the first valving path includes valves 858, 860. This valving path 858, 860 includes the metering fluid line 812, which connects to the second fluid inlet 826. As shown in these FIGS., in some embodiments of the cassette, there are two second fluid inlets 826. In practice, these two second fluid inlets 826 can be connected to the same fluid source or a different fluid source. Either way, the same fluid or a different fluid may be connected to each second fluid inlet 826. Each second fluid inlet 826 is connected to a different metering fluid line 812, 814.
  • [0143]
    The first of the two metering fluid lines connected to the second fluid inlet 826 is as follows. When valve 858 opens and valve 860 is closed and metering pump 822 is actuated, fluid is drawn from the second fluid inlet 826 and into metering fluid line 812. When valve 860 is open and valve 858 is closed and the metering pump 822 is actuated, second fluid continues on metering fluid line 812 into pod pump 820.
  • [0144]
    Referring now to the second valving path including valve 842, when valve 842 is open and pod pump 820 is actuated, fluid is pumped from pod pump 820 to one of the third fluid inlet 825. In one embodiment, this valving path is provided to send liquid into a container or source connected to third fluid inlet 825.
  • [0145]
    Referring now to the third valving path including valves 832 and 836 this valving path 832, 835 includes the metering fluid line 816, which connects to the third fluid inlet 825. As shown in these FIGS., in some embodiments of the cassette, there are two third fluid inlets 825. In practice, these two third fluid inlets 825 can be connected to the same fluid source or a different fluid source. Either way, the same fluid or a different fluid may be connected to each third fluid inlet 825. Each third fluid inlet 825 is connected to a different metering fluid line 862, 868.
  • [0146]
    When valve 832 opens and valve 836 is closed and metering pump 830 is actuated, fluid is drawn from the third fluid inlet 825 and into metering fluid line 830. When valve 836 is open and valve 832 is closed and the metering pump 830 is actuated, third fluid continues on metering fluid line 816 into first fluid outlet line 824.
  • [0147]
    Referring now to the fourth valving path, valve 846, when valve 846 is open and pod pump 820 is actuated, fluid is pumped from pod pump 820 to one of the third fluid inlet 825. In one embodiment, this valving path is provided to send liquid into a container or source connected to third fluid inlet 825.
  • [0148]
    Referring now to the fifth valving path, when valve 850 opens and pod pump 820 is actuated, fluid is pumped into the cassette 800 through the first fluid inlet 810, and into pod pump 820.
  • [0149]
    Referring now to the sixth valving path, when valve 838 is open and pod pump 820 is actuated, fluid is pumped from pod pump 820 to the mixing chamber 818 and to the first fluid outlet 824.
  • [0150]
    The seventh valving path includes valves 858, 856. This valving path 858, 856 includes the metering fluid line 812, which connects to the second fluid inlet 826. As shown in these FIGS., in some embodiments of the cassette, there are two second fluid inlets 826. In practice, these two second fluid inlets 826 can be connected the same fluid source or a different fluid source. Either way, the same fluid or a different fluid may be connected to each second fluid inlet 826. Each second fluid inlet 826 is connected to a different metering fluid line 812, 814.
  • [0151]
    When valve 858 opens and valve 856 is closed and metering pump 822 is actuated, fluid is drawn from the second fluid inlet 826 and info metering fluid line 812. When valve 856 is open and valve 858 is closed, and the metering pump is actuated, second fluid continues on metering fluid line 814 into pod pump 828.
  • [0152]
    Referring now to the eighth valving path, valve 848, when valve 848 is open and pod pump 828 is actuated, fluid is pumped from pod pump 828 to one of the third fluid inlet 825. In one embodiment, this valving path is provided to send fluid/liquid into a container or source connected to third fluid inlet 825.
  • [0153]
    Referring now to the ninth valving path including valve 844, when valve 844 is open and pod pump 828 is actuated, fluid is pumped from pod pump 828 to one of the third fluid inlet 825. In one embodiment, this valving path is provided to send liquid into a container or source connected to third fluid inlet 825.
  • [0154]
    Referring now to the tenth valving path, valve 848, when valve 848 is open and pod pump 828 is actuated, fluid is pumped from pod pump 828 to one of the third fluid inlet 825. In one embodiment, this valving path is provided to send fluid/liquid into a container or source connected to third fluid inlet 825.
  • [0155]
    The eleventh valving path including valves 854 and 856 is shown. This valving path 854, 856 includes the metering fluid line 814, which connects to the second fluid inlet 826. As shown in these FIGS., in some embodiments of the cassette, there are two second fluid inlets 826. In practice, these two second fluid inlets 826 can be connected the same fluid source or a different fluid source. Either way, the same fluid or a different fluid may be connected to each second fluid inlet 826. Each second fluid inlet 826 is connected to a different metering fluid line 812, 814.
  • [0156]
    The second of the two metering fluid lines connected to the second fluid inlet 826 is shown in FIG. 8. The twelfth valving path is as follows. When valve 854 opens and valve 856 is closed and metering pump 822 is actuated, fluid is drawn from the second fluid inlet 826 and into metering fluid line 814. When valve 856 is open and valve 854 is closed and the metering pump 822 is actuated, the second fluid continues on metering fluid line 814 into pod pump 828.
  • [0157]
    Similarly, the thirteenth valving path is seen when valve 854 opens and valve 860 is closed and metering pump 822 is actuated, fluid is drawn from the second fluid inlet 826 and into metering fluid line 814. When valve 860 is open and valve 854 is closed, and the metering pump 822 is actuated, the second fluid continues on metering fluid line 814 into pod pump 820.
  • [0158]
    Referring now to the fourteenth valving path including valve 852. When valve 852 opens and pod pump 828 is actuated, fluid is pumped into the cassette 800 through the first fluid inlet 810, and into pod pump 828.
  • [0159]
    Referring now to the fifteenth valving path, when valve 840 is open and pod pump 828 is actuated, fluid is pumped from pod pump 828 to the mixing chamber 818 and to the first fluid outlet 824. The sixteenth valving path including valve 834, when valve 834 is open and valve 836 opens, and the metering pump 830 is actuated, fluid from the third fluid inlet 825 flows on metering fluid line 862 and to metering fluid line 816.
  • [0160]
    In the exemplary fluid flow-path embodiment shown in FIG. 8, and corresponding structure of the cassette shown in FIG. 10, valves are open individually. In the exemplary embodiment, the valves are pneumatically open. Also, in the exemplary embodiment, the fluid valves are volcano valves, as described in more detail in this specification.
  • [0161]
    Referring now to FIGS. 11A-11B, the top plate 1100 of exemplary embodiment of the cassette is shown. In the exemplary embodiment, the pod pumps 820, 828 and the mixing chambers 818 on the top plate 1100, are formed in a similar fashion. In the exemplary embodiment, the pod pumps 820, 828 and mixing chamber 818, when assembled with the bottom plate, have a total volume of capacity of 38 ml. However, in other embodiments, the mixing chamber can have any size volume desired.
  • [0162]
    Referring now to FIG. 11B, the bottom view of the top plate 1100 is shown. The fluid paths are shown in this view. These fluid paths correspond to the fluid paths shown in FIGS. 12A-12B in the midplate 1200. The top plate 1100 and the top of the midplate 1200 form the liquid or fluid side of the cassette for the pod pumps 820, 828 and for one side of the mixing chamber 818. Thus, most of the liquid flow paths are on the top 1100 and midplates 1200. Referring to FIG. 12B, the first fluid inlet 810 and the first fluid outlet 824 are shown.
  • [0163]
    Still referring to FIGS. 11A and 11B, the pod pumps 820, 828 include a groove 1002 (in alternate embodiments, this is a groove). The groove 1002 is shown having a particular size and shape, however, in other embodiments, the size and shape of the groove 1002 can be any size or shape desirable. The size and shape shown in FIGS. 11A and 11B is the exemplary embodiment. In all embodiments of the groove 1002, the groove 1002 forms a path between the fluid inlet side and the fluid outlet side of the pod pumps 820, 828. In alternate embodiments, the groove 1002 is a groove in the inner pumping chamber wall of the pod pump.
  • [0164]
    The groove 1002 provides a fluid path whereby when the membrane is at the end-of-stroke there is still a fluid path between the inlet and outlet such that the pockets of fluid or air do not get trapped in the pod pump. The groove 1002 is included in both the liquid/fluid and air/actuation sides of the pod pumps 820, 828. In some embodiments, the groove 1002 may also be included in the mixing chamber 818 (see FIGS. 13A-13B with respect to the actuation/air side of the pod pumps 820, 828 and the opposite side of the mixing chamber 818. In alternate embodiments, the groove 1002 is either not included or on only one side of the pod pumps 820, 828.
  • [0165]
    In an alternate embodiment of the cassette, the liquid/fluid side of the pod pumps 820, 828 may include a feature (not shown) whereby the inlet and outlet flow paths are continuous and a rigid outer ring (not shown) is molded about the circumference of the pumping chamber is also continuous. This feature allows for the seal, formed with the membrane (not shown) to be maintained. Referring to FIG. 11E, the side view of the exemplary embodiment of the top plate 1100 is shown.
  • [0166]
    Referring now to FIGS. 12A-12B, the exemplary embodiment of the midplate 1200 is shown. The midplate 1200 is also shown in FIGS. 9A-9F and 10A-10F, where these FIGS. correspond with FIGS. 12A-12B. Thus, FIGS. 9A-9F and 10A-10F indicate the locations of the various valves and valving paths. The locations of the membranes (not shown) for the respective pod pumps 820, 828 as well as the location of the mixing chamber 818 are shown.
  • [0167]
    Referring now to FIG. 12A, in the exemplary embodiment of the cassette, sensor elements are incorporated into the cassette so as to discern various properties of the fluid being pumped. In one embodiment, three sensor elements are included. However, in the exemplary embodiment, six sensor elements (two sets of three) are included. The sensor elements are located in the sensor cell 1314, 1316. In this embodiment, a sensor cell 1314, 1316 is included as an area on the cassette for sensor(s) elements. In the exemplary embodiment, the three sensor elements of the two sensor cells 1314, 1316 are housed in respective sensor elements housings 1308, 1310, 1312 and 1318, 1320, 1322. In the exemplary embodiment, two of the sensor elements housings 1308, 1312 and 1318, 1320 accommodate a conductivity sensor elements and the third sensor elements housing 1310,1322 accommodates a temperature sensor elements. The conductivity sensor elements and temperature sensor elements can be any conductivity or temperature sensor elements in the art. In one embodiment, the conductivity sensors are graphite posts. In other embodiments, the conductivity sensor elements are posts made from stainless steel, titanium, platinum or any other metal coated to be corrosion resistant and still be electrically conductive. The conductivity sensor elements will include an electrical lead that transmits the probe information to a controller or other device. In one embodiment, the temperature sensor is a thermister potted in a stainless steel probe. However, in alternate embodiments, a combination temperature and conductivity sensor elements is used similar to the one described U.S. Patent Application entitled Sensor Apparatus Systems, Devices and Methods filed Oct. 12, 2007 (DEKA-024XX).
  • [0168]
    In alternate embodiments, there are either no sensors in the cassette or only a temperature sensor, only one or more conductivity sensors or one or more of another type of sensor.
  • [0169]
    Referring now to FIG. 12C, the side view of the exemplary embodiment of the midplate 1200 is shown.
  • [0170]
    Referring now to FIGS. 13A-13B, the bottom plate 1300 is shown. Referring first to FIG. 13A, the inner or inside surface of the bottom plate 1300 is shown. The inner or inside surface is the side that contacts the bottom surface of the midplate (not shown, see FIG. 9B). The bottom plate 1300 attaches to the air or actuation lines (not shown). The corresponding entrance holes for the air that actuates the pod pumps 820, 828 and valves (not shown, see FIGS. 10A-10F) in the midplate 1300 can be seen. Holes 810, 824 correspond to the first fluid inlet and first fluid outlet shown in FIG. 12B, 810, 824 respectively. The corresponding halves of the pod pumps 820, 828 and mixing chamber 818 are also shown, as are the grooves 1002 for the fluid paths. The actuation holes in the pumps are also shown. Unlike the top plate, the bottom plate 1300 corresponding halves of the pod pumps 820, 828 and mixing chamber 818 make apparent the difference between the pod pumps 820, 828 and mixing chamber 818. The pod pumps 820, 828 include an air/actuation path on the bottom plate 1300, while the mixing chamber 818 has identical construction to the half in the top plate. The mixing chamber 818 mixes liquid and therefore, does not include a membrane (not shown) nor an air/actuation path. The sensor cell 1314, 1316 with the three sensor element housings 1308, 1310, 1312 and 1318, 1320, 1322 are also shown.
  • [0171]
    Referring now to FIG. 13B, the actuation ports 1306 are shown on the outside or outer bottom plate 1300. An actuation source is connected to these actuation ports 1306. Again, the mixing chamber 818 does not have an actuation port as it is not actuated by air. Referring to FIG. 13C, a side view of the exemplary embodiment of the bottom plate 1300 is shown.
  • [0172]
    5.1 Membranes
  • [0173]
    In the exemplary embodiment, the membrane is a gasket o-ring membrane as shown in FIG. 5A. However, in some embodiments, a gasket o-ring membranes having texture, including, but not limited to, the various embodiments in FIG. 4D, or 5B-5D may be used. In still other embodiments, the membranes shown in FIGS. 6A-6G may also be used.
  • [0174]
    Referring next to FIGS. 14A and 14B, the assembled exemplary embodiment of the cassette 1400 is shown. FIGS. 14C and 14D are an exploded view of the exemplary embodiment of the cassette 1400. The membranes 1600 are shown. As can be seen from FIGS. 14C and 14D, there is one membrane 1602 for each of the pods pumps. In the exemplary embodiment, the membrane for the pod pumps is identical. In alternate embodiments, any membrane may be used, and one pod pump could use one embodiment of the membrane while the second pod pump can use a different embodiment of the membrane (or each pod pump can use the same membrane).
  • [0175]
    The various embodiments of the membrane used in the metering pumps 1604, in the preferred embodiment, are shown in more detail in FIGS. 5E-5H. The various embodiments of the membrane used in the valves 1222 is shown in more detail in FIGS. 2E-2G. However, in alternate embodiments, the metering pump membrane as well as the valve membranes may contain textures for example, but not limited to, the textures shown on the pod pump membranes shown in FIGS. 5A-5D.
  • [0176]
    One embodiment of the conductivity sensor elements 1314, 1316 and the temperature sensor element 1310, which make up the sensor cell 1322, are also shown in FIGS. 14C and 14D. Still referring to FIGS. 14C and 14D, the sensor elements are housed in sensor blocks (shown as 1314, 1316 in FIGS. 12B and 13A) which include areas on the bottom plate 1300 and the midplate 1200. O-rings seal the sensor housings from the fluid lines located on the upper side of the midplate 1200 and the inner side of the top plate 1100. However, in other embodiments, an o-ring is molded into the sensor block or any other method of sealing can be used.
  • [0177]
    5.2 Cross Sectional Views
  • [0178]
    Referring now to FIGS. 15A-15C, various cross sectional views of the assembled cassette are shown. Referring first to FIG. 15A, the membranes 1602 are shown in a pod pumps 820, 828. As can be seen from the cross section, the o-ring of the membrane 1602 is sandwiched by the midplate 1200 and the bottom plate 1300. A valve membrane 1606 can also be seen. As discussed above, each valve includes a membrane.
  • [0179]
    Referring now to FIG. 15B, the two conductivity sensors 1308, 1312 and the temperature sensor 1310 are shown. As can be seen from the cross section, the sensors 1308, 1310, 1312 are in the fluid line 824. Thus, the sensors 1308, 1310, 1312 are in fluid connection with the fluid line and can determine sensor data of the fluid exiting fluid outlet one 824. Still referring to FIG. 15B, a valve 836 cross section is shown. As shown in this FIG., in the exemplary embodiment, the valves are volcano valves similar to the embodiment shown and described above with respect to FIG. 2B. However, as discussed above, in alternate embodiment, other valves are used including, but not limited, to those described and shown above with respect to FIGS. 2A, 2C and 2D.
  • [0180]
    Referring now to FIG. 15C, the two conductivity sensor elements 1318, 1320 and the temperature sensor element 1322 are shown. As can be seen from the cross section, the sensor elements 1318, 1320, 1322 are in the fluid line 824. Thus, the sensor elements 1318, 1320, 1322 are in fluid connection with the fluid line and can be used to determine sensor data of the fluid entering the mixing chamber (not shown in this figure). Thus, in the exemplary embodiment, the sensor elements 1318, 1320, 1322 are used to collect data regarding fluid being pumped into the mixing chamber. Referring back to FIG. 12B, sensor elements 1308, 1310, 1312 are used to collect data regarding fluid being pumped from the mixing chamber and to the fluid outlet. However, in alternate embodiments, no sensors are or only one set, or only one type of sensor element (i.e., either temperature or conductivity sensor element) is used. Any type of sensor may be used and additionally, any embodiment of a temperature, a conductivity sensor element or a combined temperature/conductivity sensor element.
  • [0181]
    As described above, the exemplary embodiment is one cassette embodiment that incorporates the exemplary fluid flow-path schematic shown in FIG. 8. However, there are alternate embodiments of the cassette that incorporate many of the same features of the exemplary embodiment, but in a different structural design and with slightly different flow paths. One of these alternate embodiments is the embodiment shown in FIGS. 16A-20B.
  • [0182]
    Referring now to FIGS. 16A-16C, views of an alternate embodiment of the top plate 1600 are shown. The features of the top plate 1600 are alternate embodiments of corresponding features in the exemplary embodiment. This alternate embodiment includes two mixing chambers 1622, 1624 and three metering pumps. Thus, this embodiment represents the flexibility in the cassette design. In various embodiments, the cassette can mix any number of fluids, as well, can meter them separately or together. FIG. 9 shows a fluid flow-path schematic of the cassette shown in FIGS. 16A-20B.
  • [0183]
    Referring now to FIGS. 17A-17C, views of an alternate embodiment of the midplate 1700 are shown. FIGS. 18A-18C show views of an alternate embodiment of the bottom plate 1800.
  • [0184]
    Referring now to FIG. 19A, an assembled alternate embodiment of the cassette 1900 is shown. FIGS. 19C-19D show exploded views of the cassette 1900 where the pod pump membranes 1910, valve membranes 1914 and metering pump membranes 1912 are shown. The three metering pumps 1616, 1618, 1620 can be seen as well as the respective membranes 1912. In this embodiment, three fluids can be metered and controlled volumes of each can be mixed together in the mixing chambers 1622, 1624. FIGS. 20A and 20B show a cross sectional view of the assembled cassette 1900.
  • [0185]
    As this alternate embodiment shows, there are many variations of the pumping cassette and the general fluid schematic shown in FIG. 8. Thus, additional mixing chambers and metering pumps can add additional capability to the pumping cassette to mix more than two fluids together.
  • [0186]
    5.3 Exemplary Embodiments of the Pumping Cassette
  • [0187]
    In practice, the cassette may be used to pump any type of fluid from any source to any location. The types of fluid include nutritive, nonnutritive, inorganic chemicals, organic chemicals, bodily fluids or any other type of fluid. Additionally, fluid in some embodiments includes a gas, thus, in some embodiments; the cassette is used to pump a gas.
  • [0188]
    The cassette serves to pump and direct the fluid from and to the desired locations. In some embodiments, outside pumps pump the fluid into the cassette and the cassette pumps the fluid out. However, in some embodiments, the pod pumps serve to pull the fluid into the cassette and pump the fluid out of the cassette.
  • [0189]
    As discussed above, depending on the valve locations, control of the fluid paths is imparted. Thus, the valves being in different locations or additional valves are alternate embodiments of this cassette. Additionally, the fluid lines and paths shown in the figures described above are mere examples of fluid lines and paths. Other embodiments may have more, less and/or different fluid paths. In still other embodiments, valves are not present in the cassette.
  • [0190]
    The number of pod pumps described above may also vary depending on the embodiment. For example, although the exemplary and alternate embodiments shown and described above include two pod pumps, in other embodiments, the cassette includes one. In still other embodiments, the cassette includes more than two pod pumps. The pod pumps can be single pumps or work in tandem to provide a more continuous flow. Either or both may be used in various embodiments of the cassette.
  • [0191]
    The various ports are provided to impart particular fluid paths onto the cassette. These ports are not necessarily all used all of the time, instead, the variety of ports provide flexibility of use of the cassette in practice.
  • [0192]
    The pumping cassette can be used in a myriad of applications. However, in one exemplary embodiment, the pumping cassette is used to mix a solution that includes at least two ingredients/compounds. In the exemplary embodiment, three ingredients are mixed. However, in other embodiments, less than three or more than three can be mixed by adding metering pumps, mixing chambers, inlets/outlets, valves and fluid lines. These variations to the cassette design are readily discernable.
  • [0193]
    As used herein, the terms “source ingredient” or “sources of ingredients” refers to ingredients other than the fluid pumped into the cassette from the first fluid inlet. These source ingredients are contained in a container, or provided by a source, connected to the cassette.
  • [0194]
    In the exemplary embodiment, the pumping cassette includes the ability to connect four sources of ingredients to the cassette in addition to the fluid inlet line. In the exemplary embodiment, the fluid inlet is connected to a water source. However, in other embodiments, the fluid inlet line is connected to a container of a liquid/fluid solution or to another source of fluid/liquid.
  • [0195]
    In the exemplary embodiment, the four additional sources of ingredients can be four of the same source ingredients, or two of one source ingredient and two of another. Using two of each source ingredient, or four of one source ingredient, pumping and mixing can be done in a continuous manner without having to replace the sources. However, depending on the source, the number of redundant sources of each ingredient will vary. For example, the source could be a connection to a very large container, a smaller container or a seemingly “endless” source. Thus, depending on the volume being pumped and the size of the source, the number of containers of a source ingredient may vary.
  • [0196]
    One of the fluid paths described above with respect to FIG. 8 includes a path where the pod pumps pump liquid into the cassette and to two of the source ingredients sources or containers. This available functionality of the cassette allows two of the source ingredients to be, at least initially, powder that is constituted with the fluid/liquid from the fluid inlet line. As well, there is a valving path for both pod pumps that can accomplish pumping fluid to the ingredient sources. Thus, in one embodiment, the valves are controlled for a period of time such that continuous pumping of fluid into the fluid inlet and to two source ingredient containers is accomplished. This same valving path can be instituted to the other two source ingredient containers or to one of the other two source ingredient containers in addition to or in lieu of the valving path shown in FIG. 8. In other embodiments, fluid inlet liquid is pumped to only one source ingredient container.
  • [0197]
    Additionally, in some embodiments, fluid is pumped into the fluid inlet and to the source ingredients where the source ingredients are fluid. This embodiment may be used in situations where the fluid inlet fluid is a source ingredient that needs to be mixed with one of the source ingredients prior to pumping. This functionality can be designed into any embodiment of the pumping cassette. However, in some embodiments, this valving path is not included.
  • [0198]
    In the exemplary embodiment, the metering pumps allow for the pumping of the source ingredients in known volumes. Thus, careful pumping allows for mixing a solution requiring exact concentrations of the various ingredients. A single metering pump could pump multiple source ingredients. However, as an ingredient is pumped, small amounts of that ingredient may be present in the metering fluid line and thus, could contaminate the ingredient and thus, provide for an incorrect assessment of the volume of that second ingredient being pumped. Therefore, in the exemplary embodiment, at least one metering pump is provided for each source ingredient, and thus, a single metering pump is provided for two sources of source ingredients where those two sources contain identical source ingredients.
  • [0199]
    In the exemplary embodiment, for each source ingredient, a metering pump is provided. Thus, in embodiments where more than two source ingredients are present, additional metering pumps may be included for each additional source ingredient in the pumping cassette. In the exemplary embodiment, a single metering pump is connected to two source, ingredients because in the exemplary embodiment, these two source ingredients are the same. However, in alternate embodiments, one metering pump can pump more than one source ingredient and be connected to more than one source ingredient even if they are not the same.
  • [0200]
    Sensors or sensor elements may be included in the fluid lines to determine the concentration, temperature or other characteristic of the fluid being pumped. Thus, in embodiments where the source ingredient container included a powder, water having been pumped by the cassette to the source ingredient container to constitute the powder into solution, a sensor could be used to ensure the correct concentration of the source ingredient. Further, sensor elements may be included in the fluid outlet line downstream from the mixing chamber to determine characteristics of the mixed solution prior to the mixed solution exiting the cassette through the fluid outlet. Additionally, a downstream valve can be provided to ensure badly mixed solution is not pumped outside the cassette through the fluid outlet. Discussion of the exemplary embodiment of the sensor elements is included above.
  • [0201]
    One example of the pumping cassette in use is as a mixing cassette as part of a hemodialysis system. The mixing cassette would be used to mix dialysate to feed a dialysate reservoir outside the cassette. Thus, the cassette would be connected to two containers of each citric acid and NaCl/bicarbonate. Two metering pumps are present in the cassette, one dedicated to the citric acid and the other to the NaCl/Bicarbonate. Thus, one metering pump works with two source ingredient containers.
  • [0202]
    In the exemplary embodiment, the NaCl/Bicarbonate is a powder and requires the addition of water to create the fluid source ingredient solution. Thus, wafer is pumped into the first fluid inlet and into the source containers of NaCl/Bicarbonate. Both pod pumps can pump out of phase to rapidly and continuously provide the necessary water to the source containers of NaCl/Bicarbonate.
  • [0203]
    To mix the dialysate, the citric acid is pumped by a metering pump into a pod pump and then towards the mixing chamber. Water is pumped into the pod pumps as well, resulting in a desired concentration of citric acid. Sensor elements are located upstream from the mixing chamber to determine if the citric acid is in the proper concentration and also, the pod pumps can pump additional water towards the mixing chamber if necessary to achieve the proper concentration.
  • [0204]
    The NaCl/Bicarbonate is pumped by the second metering pump and into the fluid outlet line upstream from the mixing chamber. The citric acid and fluid NaCl/Bicarbonate will enter the mixing chamber. The two source ingredients will then mix and be pumped out the fluid outlet.
  • [0205]
    In some embodiments, sensor elements are located downstream from the mixing chamber. These sensor elements can ensure the concentration of the finished solution is proper. Also, in some embodiments, a valve may be located downstream from the fluid outlet. In situations where the sensor data shows the mixing has not been successful or as desired, this valve can block the dialysate from flowing into the reservoir located outside the cassette.
  • [0206]
    In alternate embodiments of the cassette, addition metering pumps can be includes to remove fluid from the fluid lines. Also, additional pod pumps may be included for additional pumping features. In alternate embodiments of this dialysate mixing process, three metering pumps and two mixing chambers are used (as shown in FIG. 9). The citric acid, salt, and bicarbonate are each pumped separately in this embodiment. One mixing chamber is similar to the one described above, and the second mixing chamber is used to mix the salt and bicarbonate prior to flowing to the other mixing chamber, where the mixing between the citric acid, NaCl/Bicarbonate will be accomplished.
  • [0207]
    Various embodiments of the cassette for mixing various solutions are readily discernable. The fluid lines, valving, metering pumps, mixing chambers, pod pumps and inlet/outlets are modular elements that can be mixed and matched to impart the desired mixing functionality onto the cassette.
  • [0208]
    In various embodiments of the cassette, the valve architecture varies in order to alter the fluid flow-path. Additionally, the sizes of the pod pumps, metering pump and mixing chambers may also vary, as well as the number of valves, pod pumps, metering pumps, sensors, mixing chambers and source ingredient containers connected to the cassette. Although in this embodiment, the valves are volcano valves, in other embodiments, the valves are not volcano valves and in some embodiments are smooth surface valves.
  • [0209]
    While the principles of the invention have been described herein, it is to be understood by those skilled in the art that this description is made only by way of example and not as a limitation as to the scope of the invention. Other embodiments are contemplated within the scope of the present invention in addition to the exemplary embodiments shown and described herein. Modifications and substitutions by one of ordinary skill in the art are considered to be within the scope of the present invention.

Claims (20)

  1. 1. A pump cassette comprising:
    a housing comprising at least one fluid inlet line and at least one fluid
    outlet line;
    at least one reciprocating pressure displacement membrane pump within said housing wherein said pressure pump pumps at least one fluid from said fluid inlet line to at least one of said fluid outlet line; and
    at least one mixing chamber within said housing, said mixing chamber fluidly connected to said fluid outlet line.
  2. 2. The cassette claimed in claim 1 wherein said reciprocating pressure displacement pump comprising:
    a curved rigid chamber wall; and
    a flexible membrane attached to said rigid chamber wall, whereby said flexible membrane and said rigid chamber wall define a pumping chamber.
  3. 3. The cassette claimed in claim 1 wherein said cassette housing comprising:
    a top plate;
    a midplate; and
    a bottom plate.
  4. 4. The cassette claimed in claim 1 further comprising at least one valve.
  5. 5. The cassette claimed in claim 4 wherein said at least one valve comprising a valve housing having a membrane, said membrane dividing said housing into two chambers.
  6. 6. The cassette claimed in claim 1 wherein said mixing chamber comprising a curved rigid chamber wall having at least one fluid inlet and at least one fluid outlet.
  7. 7. The cassette claimed in claim 1 further comprising at least one metering membrane pump within said housing, said metering pump fluidly connected to said mixing chamber on said housing and to a metering pump fluid line, wherein said metering pump fluid fine is fluidly connected to said at least one of said at least one fluid inlet lines.
  8. 8. The cassette claimed in claim 7 further comprising wherein said metering pump fluid line connected to at second fluid inlet line.
  9. 9. A pump cassette comprising:
    a housing comprising at least two fluid inlet lines and at least one fluid outlet line;
    at least one reciprocating pressure displacement membrane pump within said housing wherein said pressure pump pumps a fluid from at least one of said fluid inlet line to at lease one of said fluid outlet line;
    at least one mixing chamber within said housing, said mixing chamber fluidly connected to said fluid outlet line; and
    at least one metering membrane pump within said housing, said metering membrane pump fluidly connected to said mixing chamber on said housing and to a metering pump fluid line, wherein said metering pump fluid line is fluidly connected to said at least one of said at least two fluid inlet lines.
  10. 10. The cassette claimed in claim 9 wherein said reciprocating pressure displacement pump comprising:
    a curved rigid chamber wall; and
    a flexible membrane attached to said rigid chamber wall, whereby said flexible membrane and said rigid chamber wall define a pumping chamber.
  11. 11. The cassette claimed in claim 9 wherein said cassette housing comprising:
    a top plate;
    a midplate; and
    a bottom plate.
  12. 12. The cassette claimed in claim 9 wherein said mixing chamber comprising a curved rigid chamber wall having at least one fluid inlet and at least one fluid outlet.
  13. 13. The cassette claimed in claim 9 further comprising at least one valve.
  14. 14. The cassette claimed in claim 13 wherein said at least one valve comprising a valve housing having a membrane, said membrane dividing said housing into two chambers.
  15. 15. A pump cassette comprising:
    a housing comprising at least three fluid inlet lines and at least one fluid outlet line;
    at least two reciprocating pressure displacement membrane pumps within said housing wherein said pressure pump pumps a fluid from at least one of said fluid inlet lines to at lease one of said fluid outlet line;
    at least one mixing chamber within said housing, said mixing chamber fluidly connected to said fluid outlet line; and
    at least two metering membrane pumps within said housing, said metering pumps fluidly connected to respective fluid inlet lines and to said mixing chamber on said housing wherein said metering pumps pump a volume of a respective fluid from said fluid inlet lines to a fluid line fluidly connected to said mixing chamber.
  16. 16. The cassette claimed in claim 9 wherein said reciprocating pressure displacement pump comprising:
    a curved rigid chamber wall; and
    a flexible membrane attached to said rigid chamber wall, whereby said flexible membrane and said rigid chamber wall define a pumping chamber.
  17. 17. The cassette claimed in claim 15 wherein said cassette housing comprising;
    a top plate;
    a midplate; and
    a bottom plate.
  18. 18. The cassette claimed in claim 15 wherein said mixing chamber comprising a curved rigid chamber wall having at least one fluid inlet and at least one fluid outlet.
  19. 19. The cassette claimed in claim 15 further comprising at least one valve.
  20. 20. The cassette claimed in claim 19 wherein said at least one valve comprising a valve housing having a membrane, said membrane dividing said housing into two chambers.
US11871787 2007-02-27 2007-10-12 Pumping Cassette Abandoned US20080253911A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US90402407 true 2007-02-27 2007-02-27
US92131407 true 2007-04-02 2007-04-02
US11871787 US20080253911A1 (en) 2007-02-27 2007-10-12 Pumping Cassette

Applications Claiming Priority (43)

Application Number Priority Date Filing Date Title
US11871787 US20080253911A1 (en) 2007-02-27 2007-10-12 Pumping Cassette
US12199077 US9028691B2 (en) 2007-02-27 2008-08-27 Blood circuit assembly for a hemodialysis system
US12199068 US8562834B2 (en) 2007-02-27 2008-08-27 Modular assembly for a portable hemodialysis system
US12199055 US8393690B2 (en) 2007-02-27 2008-08-27 Enclosure for a portable hemodialysis system
US12199166 US20090107335A1 (en) 2007-02-27 2008-08-27 Air trap for a medical infusion device
US12199196 US8425471B2 (en) 2007-02-27 2008-08-27 Reagent supply for a hemodialysis system
CA 2971044 CA2971044A1 (en) 2007-10-12 2008-10-10 Apparatus and methods for hemodialysis
KR20157011558A KR101657569B1 (en) 2007-10-12 2008-10-10 Device and method for hemodialysis
KR20107010384A KR101573948B1 (en) 2007-10-12 2008-10-10 Apparatus and method for hemodialysis
EP20170159187 EP3228337A1 (en) 2007-10-12 2008-10-10 Connector system for a hemodialysis apparatus
CA 2971041 CA2971041A1 (en) 2007-10-12 2008-10-10 Apparatus and methods for hemodialysis
EP20080838971 EP2197513B1 (en) 2007-10-12 2008-10-10 Blood circuit assembly for a dialysis unit
CN 200880121285 CN101986776B (en) 2007-10-12 2008-10-10 Apparatus and methods for hemodialysis
KR20167027838A KR101780620B1 (en) 2007-10-12 2008-10-10 Apparatus and method for hemodialysis
CA 2971046 CA2971046A1 (en) 2007-10-12 2008-10-10 Apparatus and methods for hemodialysis
KR20147023314A KR20140110097A (en) 2007-10-12 2008-10-10 Apparatus and method for hemodialysis
PCT/US2008/011663 WO2009051669A1 (en) 2007-10-12 2008-10-10 Apparatus and methods for hemodialysis
CA 2702385 CA2702385C (en) 2007-10-12 2008-10-10 Apparatus and methods for hemodialysis
KR20177002616A KR101769521B1 (en) 2007-10-12 2008-10-10 Apparatus and method for hemodialysis
CN 201510086488 CN104689393B (en) 2007-10-12 2008-10-10 Hemodialysis apparatus and method
EP20110150584 EP2319551B1 (en) 2007-10-12 2008-10-10 Apparatus for hemodialysis
KR20147009763A KR101574748B1 (en) 2007-10-12 2008-10-10 Apparatus and method for hemodialysis
KR20167024526A KR101702643B1 (en) 2007-10-12 2008-10-10 Device and method for hemodialysis
KR20177022556A KR101838530B1 (en) 2007-10-12 2008-10-10 Enclosure for containing a portable hemodialysis unit
KR20187006667A KR20180029265A (en) 2007-10-12 2008-10-10 Enclosure for containing a portable hemodialysis unit
JP2010528896A JP5324587B2 (en) 2007-10-12 2008-10-10 Apparatus and method for hemodialysis
EP20160152813 EP3037117B1 (en) 2007-10-12 2008-10-10 Blood line connector
JP2011243747A JP5270745B2 (en) 2007-10-12 2011-11-07 Apparatus and method for hemodialysis
US13352250 US9649418B2 (en) 2007-02-27 2012-01-17 Pumping cassette
US13619266 US8992075B2 (en) 2007-02-27 2012-09-14 Sensor apparatus systems, devices and methods
US13790974 US9539379B2 (en) 2007-02-27 2013-03-08 Enclosure for a portable hemodialysis system
JP2013149599A JP5749767B2 (en) 2007-10-12 2013-07-18 3 or reagent supply connector system in hemodialysis device
US14059806 US20140102958A1 (en) 2007-02-27 2013-10-22 Modular assembly for a portable hemodialysis system
US14132838 US9597442B2 (en) 2007-02-27 2013-12-18 Air trap for a medical infusion device
US14672764 US9535021B2 (en) 2007-02-27 2015-03-30 Sensor apparatus systems, devices and methods
US14692801 US9987407B2 (en) 2007-02-27 2015-04-22 Blood circuit assembly for a hemodialysis system
JP2015099430A JP5782207B2 (en) 2007-10-12 2015-05-14 Modular assembly system for a portable hemodialysis unit
JP2015142465A JP5824183B2 (en) 2007-10-12 2015-07-16 Housing for containing a portable hemodialysis unit
JP2015200155A JP6027206B2 (en) 2007-10-12 2015-10-08 Housing for containing a portable hemodialysis unit
JP2016201759A JP2017029785A (en) 2007-10-12 2016-10-13 Triradius reagent supply connector and triradius sterilization connector
US15399895 US9795728B2 (en) 2007-02-27 2017-01-06 Enclosure for a portable hemodialysis system
US15463888 US20170252503A1 (en) 2007-02-27 2017-03-20 Air trap for a medical infusion device
US15789916 US20180055984A1 (en) 2007-02-27 2017-10-20 Enclosure for a portable hemodialysis system

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
US11871712 Continuation-In-Part US8317492B2 (en) 2007-02-27 2007-10-12 Pumping cassette
US11871793 Continuation-In-Part US8888470B2 (en) 2007-02-27 2007-10-12 Pumping cassette

Related Child Applications (7)

Application Number Title Priority Date Filing Date
US11871793 Continuation-In-Part US8888470B2 (en) 2007-02-27 2007-10-12 Pumping cassette
US11871712 Continuation-In-Part US8317492B2 (en) 2007-02-27 2007-10-12 Pumping cassette
US12199055 Continuation-In-Part US8393690B2 (en) 2007-02-27 2008-08-27 Enclosure for a portable hemodialysis system
US12199077 Continuation-In-Part US9028691B2 (en) 2007-02-27 2008-08-27 Blood circuit assembly for a hemodialysis system
US12199166 Continuation-In-Part US20090107335A1 (en) 2007-02-27 2008-08-27 Air trap for a medical infusion device
US12199068 Continuation-In-Part US8562834B2 (en) 2007-02-27 2008-08-27 Modular assembly for a portable hemodialysis system
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Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100327849A1 (en) * 2006-04-14 2010-12-30 Deka Products Limited Partnership Sensor apparatus systems, devices and methods
US20110071465A1 (en) * 2008-01-23 2011-03-24 Deka Research & Development Fluid volume determination for medical treatment system
US7967022B2 (en) 2007-02-27 2011-06-28 Deka Products Limited Partnership Cassette system integrated apparatus
US8042563B2 (en) 2007-02-27 2011-10-25 Deka Products Limited Partnership Cassette system integrated apparatus
US8114276B2 (en) 2007-10-24 2012-02-14 Baxter International Inc. Personal hemodialysis system
US8246826B2 (en) 2007-02-27 2012-08-21 Deka Products Limited Partnership Hemodialysis systems and methods
US8292594B2 (en) 2006-04-14 2012-10-23 Deka Products Limited Partnership Fluid pumping systems, devices and methods
US8357298B2 (en) 2007-02-27 2013-01-22 Deka Products Limited Partnership Hemodialysis systems and methods
US8393690B2 (en) 2007-02-27 2013-03-12 Deka Products Limited Partnership Enclosure for a portable hemodialysis system
US8409441B2 (en) 2007-02-27 2013-04-02 Deka Products Limited Partnership Blood treatment systems and methods
US8425471B2 (en) 2007-02-27 2013-04-23 Deka Products Limited Partnership Reagent supply for a hemodialysis system
US8491184B2 (en) 2007-02-27 2013-07-23 Deka Products Limited Partnership Sensor apparatus systems, devices and methods
US8562834B2 (en) 2007-02-27 2013-10-22 Deka Products Limited Partnership Modular assembly for a portable hemodialysis system
US8708950B2 (en) 2010-07-07 2014-04-29 Deka Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
US8771508B2 (en) 2008-08-27 2014-07-08 Deka Products Limited Partnership Dialyzer cartridge mounting arrangement for a hemodialysis system
US8863772B2 (en) 2008-08-27 2014-10-21 Deka Products Limited Partnership Occluder for a medical infusion system
US9028691B2 (en) 2007-02-27 2015-05-12 Deka Products Limited Partnership Blood circuit assembly for a hemodialysis system
US9078971B2 (en) 2008-01-23 2015-07-14 Deka Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
US9364655B2 (en) 2012-05-24 2016-06-14 Deka Products Limited Partnership Flexible tubing occlusion assembly
US9517295B2 (en) 2007-02-27 2016-12-13 Deka Products Limited Partnership Blood treatment systems and methods
US9597442B2 (en) 2007-02-27 2017-03-21 Deka Products Limited Partnership Air trap for a medical infusion device
US9724458B2 (en) 2011-05-24 2017-08-08 Deka Products Limited Partnership Hemodialysis system
US9861732B2 (en) 2011-11-04 2018-01-09 Deka Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
US9861733B2 (en) 2012-03-23 2018-01-09 Nxstage Medical Inc. Peritoneal dialysis systems, devices, and methods
US9907897B2 (en) 2011-03-23 2018-03-06 Nxstage Medical, Inc. Peritoneal dialysis systems, devices, and methods
US9999717B2 (en) 2011-05-24 2018-06-19 Deka Products Limited Partnership Systems and methods for detecting vascular access disconnection

Families Citing this family (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6877713B1 (en) 1999-07-20 2005-04-12 Deka Products Limited Partnership Tube occluder and method for occluding collapsible tubes
US7544179B2 (en) 2002-04-11 2009-06-09 Deka Products Limited Partnership System and method for delivering a target volume of fluid
DE10224750A1 (en) 2002-06-04 2003-12-24 Fresenius Medical Care De Gmbh An apparatus for treating a medical fluid
US8038639B2 (en) * 2004-11-04 2011-10-18 Baxter International Inc. Medical fluid system with flexible sheeting disposable unit
US8903492B2 (en) 2005-02-07 2014-12-02 Medtronic, Inc. Ion imbalance detector
US7935074B2 (en) 2005-02-28 2011-05-03 Fresenius Medical Care Holdings, Inc. Cassette system for peritoneal dialysis machine
US8197231B2 (en) 2005-07-13 2012-06-12 Purity Solutions Llc Diaphragm pump and related methods
EP2197513B1 (en) * 2007-10-12 2017-04-26 DEKA Products Limited Partnership Blood circuit assembly for a dialysis unit
US20090007642A1 (en) * 2007-07-05 2009-01-08 Baxter International Inc. Dialysis fluid measurement method and apparatus using conductive contacts
US8287724B2 (en) * 2007-07-05 2012-10-16 Baxter International Inc. Dialysis fluid measurement systems using conductive contacts
US20110185772A1 (en) * 2007-08-30 2011-08-04 Raymond David Ruthven Variable pressure water delivery system
US8057437B2 (en) * 2007-08-31 2011-11-15 Hospira, Inc. Radially sealing vavle for an infusion set
US8597505B2 (en) 2007-09-13 2013-12-03 Fresenius Medical Care Holdings, Inc. Portable dialysis machine
US9199022B2 (en) 2008-09-12 2015-12-01 Fresenius Medical Care Holdings, Inc. Modular reservoir assembly for a hemodialysis and hemofiltration system
US9358331B2 (en) 2007-09-13 2016-06-07 Fresenius Medical Care Holdings, Inc. Portable dialysis machine with improved reservoir heating system
US9308307B2 (en) 2007-09-13 2016-04-12 Fresenius Medical Care Holdings, Inc. Manifold diaphragms
US8105487B2 (en) 2007-09-25 2012-01-31 Fresenius Medical Care Holdings, Inc. Manifolds for use in conducting dialysis
EP2217301A2 (en) * 2007-10-12 2010-08-18 DEKA Products Limited Partnership Systems, devices and methods for cardiopulmonary treatment and procedures
US8137553B2 (en) 2007-11-29 2012-03-20 Fresenius Medical Care Holdings, Inc. Priming system and method for dialysis systems
WO2009073567A1 (en) 2007-11-29 2009-06-11 Xcorporeal. Inc. System and method for conducting hemodialysis and hemofiltration
DE102008011828A1 (en) * 2008-02-29 2009-09-10 Fresenius Medical Care Deutschland Gmbh Method and apparatus for heating solutions, preferably dialysis solutions
US20100056975A1 (en) * 2008-08-27 2010-03-04 Deka Products Limited Partnership Blood line connector for a medical infusion device
US8240636B2 (en) 2009-01-12 2012-08-14 Fresenius Medical Care Holdings, Inc. Valve system
DE102009000802A1 (en) * 2009-02-12 2010-08-19 Robert Bosch Gmbh Pressure relief valve for a packaging container
US8192401B2 (en) 2009-03-20 2012-06-05 Fresenius Medical Care Holdings, Inc. Medical fluid pump systems and related components and methods
WO2011008858A1 (en) 2009-07-15 2011-01-20 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
US8641671B2 (en) 2009-07-30 2014-02-04 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US8720913B2 (en) 2009-08-11 2014-05-13 Fresenius Medical Care Holdings, Inc. Portable peritoneal dialysis carts and related systems
US9399091B2 (en) 2009-09-30 2016-07-26 Medtronic, Inc. System and method to regulate ultrafiltration
EP2488226B1 (en) 2009-10-15 2013-11-20 Gambro Lundia AB Membrane pump system
WO2011049196A1 (en) * 2009-10-23 2011-04-28 旭化成クラレメディカル株式会社 Blood dialysis device, method for operating blood dialysis device, and water-removing system
US8460228B2 (en) * 2009-10-27 2013-06-11 Nxstage Medical Inc. Methods, devices, and systems for parallel control of infusion device
WO2011053810A3 (en) * 2009-10-30 2011-06-30 Deka Products Limited Partnership Apparatus and method for detecting disconnection of an intravascular access device
DE102009060330A1 (en) * 2009-12-23 2011-06-30 Fresenius Medical Care Deutschland GmbH, 61352 Dialysis machine, particularly peritoneal
CN103153359B (en) * 2009-12-24 2015-12-02 昆山韦睿医疗科技有限公司 Automated peritoneal dialysis circulatory system and its application
DE102010005745A1 (en) * 2010-01-26 2011-07-28 Fresenius Medical Care Deutschland GmbH, 61352 dialysis machine
JP5569014B2 (en) * 2010-02-03 2014-08-13 セイコーエプソン株式会社 Fluid transportation device
JP5908667B2 (en) * 2010-02-25 2016-04-26 ザマ・ジャパン株式会社 Dustproof sealing structure of the valve shaft in the rotary throttle valve type carburetor
DE102010003642A1 (en) * 2010-03-15 2011-09-15 Fresenius Medical Care Deutschland Gmbh Cartridge having a sensor for determining the difference of a first and a second liquid stream
US8910836B2 (en) * 2010-03-19 2014-12-16 Ambrosios Kambouris Valve assembly
US9132219B2 (en) 2010-04-16 2015-09-15 Baxter International Inc. Therapy prediction and optimization of serum potassium for renal failure blood therapy, especially home hemodialysis
WO2011130669A1 (en) 2010-04-16 2011-10-20 Baxter International Inc. Therapy prediction and optimization for renal failure blood therapy, especially home hemodialysis
US8845570B2 (en) 2010-04-16 2014-09-30 Baxter International Inc. Therapy prediction and optimization for renal failure blood therapy, especially home hemodialysis
EP3229159A1 (en) 2013-08-16 2017-10-11 Baxter International Inc Therapy prediction and optimization of serum potassium for renal failure blood therapy, especially home hemodialysis
WO2012012758A3 (en) * 2010-07-23 2012-04-19 Medela Holding Ag Pumping device, as for enteral feeding assembly
JP2012075574A (en) * 2010-09-30 2012-04-19 Terumo Corp Automatic peritoneal dialysis machine
DE102010053973A1 (en) 2010-12-09 2012-06-14 Fresenius Medical Care Deutschland Gmbh A medical apparatus with a heater
CN102553040B (en) * 2010-12-17 2014-07-02 陈庆堂 Inhaler of filtered medicinal power
US9694125B2 (en) 2010-12-20 2017-07-04 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
US9624915B2 (en) 2011-03-09 2017-04-18 Fresenius Medical Care Holdings, Inc. Medical fluid delivery sets and related systems and methods
WO2012154352A1 (en) * 2011-04-21 2012-11-15 Fresenius Medical Care Holdings, Inc. Medical fluid pumping systems and related devices and methods
US9848778B2 (en) 2011-04-29 2017-12-26 Medtronic, Inc. Method and device to monitor patients with kidney disease
US9456755B2 (en) 2011-04-29 2016-10-04 Medtronic, Inc. Method and device to monitor patients with kidney disease
US8926542B2 (en) 2011-04-29 2015-01-06 Medtronic, Inc. Monitoring fluid volume for patients with renal disease
US9186449B2 (en) 2011-11-01 2015-11-17 Fresenius Medical Care Holdings, Inc. Dialysis machine support assemblies and related systems and methods
EP2800592A4 (en) 2012-01-04 2015-02-25 Medtronic Inc Multi-staged filtration system for blood fluid removal
DE202012003948U1 (en) * 2012-04-20 2012-05-15 Bürkert Werke GmbH Pneumatic metering and pneumatic metering system
US9555186B2 (en) 2012-06-05 2017-01-31 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US9610392B2 (en) 2012-06-08 2017-04-04 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
US9500188B2 (en) 2012-06-11 2016-11-22 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
CA2883826A1 (en) * 2012-10-31 2014-05-08 Pluristem Ltd. Method and device for thawing biological material
CN106039444A (en) * 2012-12-13 2016-10-26 甘布罗伦迪亚股份公司 Cassette for pumping a treatment solution through a dialyzer
US9157786B2 (en) 2012-12-24 2015-10-13 Fresenius Medical Care Holdings, Inc. Load suspension and weighing system for a dialysis machine reservoir
US9707328B2 (en) 2013-01-09 2017-07-18 Medtronic, Inc. Sorbent cartridge to measure solute concentrations
US9526822B2 (en) 2013-02-01 2016-12-27 Medtronic, Inc. Sodium and buffer source cartridges for use in a modular controlled compliant flow path
US9623164B2 (en) 2013-02-01 2017-04-18 Medtronic, Inc. Systems and methods for multifunctional volumetric fluid control
US9144640B2 (en) 2013-02-02 2015-09-29 Medtronic, Inc. Sorbent cartridge configurations for improved dialysate regeneration
US9827361B2 (en) 2013-02-02 2017-11-28 Medtronic, Inc. pH buffer measurement system for hemodialysis systems
DE102013102397A1 (en) * 2013-03-11 2014-09-11 Bürkert Werke GmbH Dosing housing part for a metering unit and metering unit
US9188490B2 (en) * 2013-03-12 2015-11-17 Rosemount Inc. Thermowell insert
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US9561323B2 (en) 2013-03-14 2017-02-07 Fresenius Medical Care Holdings, Inc. Medical fluid cassette leak detection methods and devices
US9421329B2 (en) 2013-03-15 2016-08-23 Tandem Diabetes Care, Inc. Infusion device occlusion detection system
US9180243B2 (en) 2013-03-15 2015-11-10 Tandem Diabetes Care, Inc. Detection of infusion pump conditions
GB201305758D0 (en) * 2013-03-28 2013-05-15 Quanta Fluid Solutions Ltd Blood Pump
EP2999497A4 (en) * 2014-04-22 2016-10-26 Fresenius Med Care Hldg Inc Manifold diaphragms
DE102013013415A1 (en) 2013-08-09 2015-02-12 Fresenius Medical Care Deutschland Gmbh cassette module
US9354640B2 (en) 2013-11-11 2016-05-31 Fresenius Medical Care Holdings, Inc. Smart actuator for valve
US20150131022A1 (en) * 2013-11-13 2015-05-14 Shenzhen China Star Optoelectronics Technology Co. Ltd. Multiple display monitor
US8960010B1 (en) * 2013-12-23 2015-02-24 Fresenius Medical Care Holdings, Inc. Automatic detection and adjustment of a pressure pod diaphragm
EP2921705A1 (en) * 2014-03-20 2015-09-23 Annovi Reverberi S.p.A. A diaphragm-plate group for diaphragm pumps
WO2016049542A3 (en) * 2014-09-25 2016-05-19 Nxstage Medical, Inc. Medicament preparation and treatment devices, methods, and systems
EP3197519A1 (en) * 2014-09-26 2017-08-02 Fresenius Medical Care Holdings, Inc. Pressure output device for extracorporeal hemodialysis machine
US9903364B2 (en) * 2014-12-05 2018-02-27 Aktiebolaget Skf Backup lubricant supply system
US9895479B2 (en) 2014-12-10 2018-02-20 Medtronic, Inc. Water management system for use in dialysis
US9713665B2 (en) 2014-12-10 2017-07-25 Medtronic, Inc. Degassing system for dialysis
DE102015016670A1 (en) * 2015-12-21 2017-06-22 Fresenius Medical Care Deutschland Gmbh A blood treatment apparatus comprising a metering pump with a diaphragm and a valve and method of metering
WO2018026778A1 (en) * 2016-08-01 2018-02-08 Walbro Llc Fluid driven diaphragm pump
DE102016010222A1 (en) * 2016-08-20 2018-02-22 Fresenius Medical Care Deutschland Gmbh Apparatus and method for providing dialysis and dialysis device

Citations (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2816514A (en) * 1954-09-17 1957-12-17 Designers For Industry Inc Vibratory pump
US3539081A (en) * 1968-07-05 1970-11-10 Jet Spray Cooler Inc Valve for beverage dispensers
US3759483A (en) * 1971-05-14 1973-09-18 T Baxter Fluid actuated control valve
US3827561A (en) * 1972-09-20 1974-08-06 Milton Roy Co Deaerator for dialysis system
US3882861A (en) * 1973-09-24 1975-05-13 Vital Assists Auxiliary control for a blood pump
US4096859A (en) * 1977-04-04 1978-06-27 Agarwal Mahesh C Apparatus for peritoneal dialysis
US4155852A (en) * 1976-11-19 1979-05-22 Halbert Fischel Low leakage current medical instrument
US4266814A (en) * 1979-03-23 1981-05-12 Vfp Corporation Plastic tube adapter
US4282099A (en) * 1979-12-10 1981-08-04 Jones John L Integral partitioned hemodialysis unit
US4322054A (en) * 1980-12-29 1982-03-30 Red Valve Company, Inc. Pinch valve
US4398908A (en) * 1980-11-28 1983-08-16 Siposs George G Insulin delivery system
US4439188A (en) * 1980-09-15 1984-03-27 Baxter Travenol Laboratories, Inc. Tube connector
US4490254A (en) * 1980-02-25 1984-12-25 Bentley Laboratories, Inc. Blood filter
US4501405A (en) * 1983-06-21 1985-02-26 Bunnell Life Systems, Inc. Frictionless valve/pump
US4585442A (en) * 1984-07-26 1986-04-29 Ivy Medical, Inc. Miniature intravenous infusion rate controller
US4623450A (en) * 1981-06-16 1986-11-18 Hospal Industrie Artificial kidney
US4695385A (en) * 1985-04-29 1987-09-22 Colorado Medical, Inc. Dialyzer reuse system
US4828543A (en) * 1986-04-03 1989-05-09 Weiss Paul I Extracorporeal circulation apparatus
US4833329A (en) * 1987-11-20 1989-05-23 Mallinckrodt, Inc. System for generating and containerizing radioisotopes
US5033513A (en) * 1980-10-29 1991-07-23 Proprietary Technology, Inc. Swivelable quick connector assembly
US5061241A (en) * 1989-01-19 1991-10-29 Stephens Jr Harry W Rapid infusion device
US5105981A (en) * 1990-11-19 1992-04-21 Thomas Gehman Selectively shakeable freestanding particulate matter reservoir
US5110477A (en) * 1990-02-13 1992-05-05 Howard David B Dialyzer clearance check system
US5300044A (en) * 1991-09-26 1994-04-05 Baxter International Inc. Intravenous tube safety apparatus
USD350850S (en) * 1993-04-20 1994-09-27 Paolo Maniglio Jewelry case
US5351686A (en) * 1990-10-06 1994-10-04 In-Line Diagnostics Corporation Disposable extracorporeal conduit for blood constituent monitoring
US5385540A (en) * 1993-05-26 1995-01-31 Quest Medical, Inc. Cardioplegia delivery system
US5411472A (en) * 1992-07-30 1995-05-02 Galen Medical, Inc. Low trauma blood recovery system
US5441343A (en) * 1993-09-27 1995-08-15 Topometrix Corporation Thermal sensing scanning probe microscope and method for measurement of thermal parameters of a specimen
US5441636A (en) * 1993-02-12 1995-08-15 Cobe Laboratories, Inc. Integrated blood treatment fluid module
US5527507A (en) * 1992-10-01 1996-06-18 American Sterilizer Company Accumulator based liquid metering system and method
US5541344A (en) * 1994-06-30 1996-07-30 G. D. Searle & Co. Intermediates useful in a process for the preparation of azanoradamantane benzamides
US5591344A (en) * 1995-02-13 1997-01-07 Aksys, Ltd. Hot water disinfection of dialysis machines, including the extracorporeal circuit thereof
US5632894A (en) * 1994-06-24 1997-05-27 Gish Biomedical, Inc. Arterial blood filter with upwardly inclining delivery inlet conduit
US5651765A (en) * 1995-04-27 1997-07-29 Avecor Cardiovascular Inc. Blood filter with concentric pleats and method of use
US5692729A (en) * 1996-02-16 1997-12-02 Vision-Sciences, Inc. Pressure equalized flow control apparatus and method for endoscope channels
US5782508A (en) * 1980-10-29 1998-07-21 Proprietary Technologies, Inc. Swivelable quick connector assembly
US5879316A (en) * 1990-12-28 1999-03-09 University Of Pittsburgh Of The Commonwealth System Of Higher Education Portable and modular cardiopulmonary bypass apparatus and associated aortic balloon catheter and associated method
US5931648A (en) * 1995-05-30 1999-08-03 Servicio Regional De Salud, De La Consejeria De Salud De La Comunidad De Madrid Vacuum actuated tubular blood pumping device with active values and application of the same
US6139819A (en) * 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US6146523A (en) * 1995-02-13 2000-11-14 Aksys, Ltd. User interface and method for control of medical instruments, such as dialysis machines
US6171261B1 (en) * 1999-08-06 2001-01-09 Becton Dickinson And Company Specimen collection device and method of delivering fluid specimens to test tubes
US6176904B1 (en) * 1999-07-02 2001-01-23 Brij M. Gupta Blood filter
US6491656B1 (en) * 1996-11-22 2002-12-10 Therakos, Inc. Integrated cassette for controlling fluid having an integral filter
US6543814B2 (en) * 2000-08-10 2003-04-08 John M. Bartholomew Quick connector
US6595948B2 (en) * 2000-10-04 2003-07-22 Terumo Kabushiki Kaisha Peritoneal dialysis apparatus
US20030220607A1 (en) * 2002-05-24 2003-11-27 Don Busby Peritoneal dialysis apparatus
US20030220599A1 (en) * 2002-05-24 2003-11-27 Lundtveit Loren M. One-piece tip protector and organizer
US6663359B2 (en) * 1999-07-20 2003-12-16 Deka Products Limited Partnership Pump chamber having at least one spacer for inhibiting the pumping of a gas
US6723062B1 (en) * 1999-09-03 2004-04-20 Baxter International Inc. Fluid pressure actuated blood pumping systems and methods with continuous inflow and pulsatile outflow conditions
US20040101026A1 (en) * 2001-05-23 2004-05-27 Metran Co., Ltd. Inspired air temperature measuring device in respiratory circuit
US20050069427A1 (en) * 2002-09-02 2005-03-31 Christiane Roemuss Housing for a fluid flow engine
US20050095141A1 (en) * 2003-10-30 2005-05-05 Deka Products Limited Partnership System and method for pumping fluid using a pump cassette
US20050126988A1 (en) * 2003-02-19 2005-06-16 Thacker Kris O. Water clarification system with weir
US20050274658A1 (en) * 2004-06-09 2005-12-15 Rosenbaum Benjamin P Dialysis system
US20060002823A1 (en) * 2000-09-11 2006-01-05 Feldstein Mark J Fluidics system
US7124996B2 (en) * 2004-07-16 2006-10-24 Cardinal Health 303, Inc. Automatic clamp apparatus for IV infusion sets used in pump devices
US7175606B2 (en) * 2002-05-24 2007-02-13 Baxter International Inc. Disposable medical fluid unit having rigid frame
US7214210B2 (en) * 1997-08-22 2007-05-08 Deka Products Limited Partnership Cassette and method for drug preparation and delivery
US20070166181A1 (en) * 2002-03-14 2007-07-19 Billy Nilson Ambulatory infusion membrane pump
US7303540B2 (en) * 2004-04-26 2007-12-04 Chf Solutions, Inc. User interface for blood treatment device
US7465285B2 (en) * 2003-09-03 2008-12-16 Therakos, Inc. Control system for driving fluids through an extracorporeal blood circuit
US7488448B2 (en) * 2004-03-01 2009-02-10 Indian Wells Medical, Inc. Method and apparatus for removal of gas bubbles from blood
US7500962B2 (en) * 2002-05-24 2009-03-10 Baxter International Inc. Medical fluid machine with air purging pump
US20090107335A1 (en) * 2007-02-27 2009-04-30 Deka Products Limited Partnership Air trap for a medical infusion device
US20090154524A1 (en) * 2006-04-28 2009-06-18 Agostino Girelli Integrated System for Hydro-Thermo-Sanitary Apparatuses
US20090173682A1 (en) * 2007-11-29 2009-07-09 Thomas Patrick Robinson System and Method for Conducting Hemodialysis and Hemofiltration
US7561968B2 (en) * 2004-10-13 2009-07-14 The Boeing Company Scale factor calibration and compensation for angular position resolver
US7559524B2 (en) * 1999-07-20 2009-07-14 Deka Products Limited Partnership Tube occluder for occluding collapsible tubes
US7727176B2 (en) * 2003-02-07 2010-06-01 Gambro Lundia Ab Machine for extracorporeal blood treatment coupled to a support element
US7776301B2 (en) * 2005-03-17 2010-08-17 Nox Ii, Ltd. Reducing mercury emissions from the burning of coal
US7815595B2 (en) * 2002-05-24 2010-10-19 Baxter International Inc. Automated dialysis pumping system
US7867214B2 (en) * 2002-07-19 2011-01-11 Baxter International Inc. Systems and methods for performing peritoneal dialysis
US7896022B2 (en) * 2006-06-07 2011-03-01 Eaton Corporation On-board refueling vapor recovery system with vent line check valve
US20110092875A1 (en) * 2008-04-30 2011-04-21 Gambro Lundia Ab Degassing device
US20110218600A1 (en) * 2006-04-14 2011-09-08 Deka Products Limited Partnership Heat exchange systems, devices and methods

Family Cites Families (407)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US356997A (en) 1887-02-01 Simeon gil
US1693526A (en) 1927-06-15 1928-11-27 Charles S Owens Hinge
US2203859A (en) 1936-05-28 1940-06-11 Brendlin Adolf High pressure membrane
US2339876A (en) 1941-01-13 1944-01-25 Pesco Products Co Accumulator
US2529028A (en) 1947-07-31 1950-11-07 Landon Standard Pools Chemical feeder
US2741099A (en) 1953-02-11 1956-04-10 Brewer Titchener Corp Apparatus for indicating and controlling the temperature of products within predetermined limits
US3016563A (en) 1959-03-04 1962-01-16 Jong George Edward De Combined hinge and catch
US3083943A (en) 1959-07-06 1963-04-02 Anbrey P Stewart Jr Diaphragm-type valve
US3200648A (en) 1963-02-04 1965-08-17 William H Waggaman Method and apparatus for comparing smoking properties of various cigarettes
US3508656A (en) 1968-04-10 1970-04-28 Milton Roy Co Portable dialysate supply system
US3656873A (en) 1970-11-06 1972-04-18 Peter Schiff Pulsatile by-pass blood pump
USRE27849E (en) 1971-11-30 1973-12-25 Dynamic action valveless artifjcial heart utilizing dual fluid oscillator
US3936729A (en) 1974-02-28 1976-02-03 Petrolite Corporation Conductivity measurement probe
FR2326235B1 (en) 1975-10-01 1979-04-20 Renault
DE2647384C3 (en) 1975-11-27 1979-06-13 Felix Dr. 8000 Muenchen Unger
US4133312A (en) 1976-10-13 1979-01-09 Cordis Dow Corp. Connector for attachment of blood tubing to external arteriovenous shunts and fistulas
US4161264A (en) 1977-06-17 1979-07-17 Johnson Bryan E Fluid metering and mixing device having inlet and outlet valves
FR2405610B1 (en) 1977-10-07 1980-08-01 Leboeuf Lola
US4222127A (en) 1978-06-02 1980-09-16 Donachy And Pierce Blood pump and method of pumping blood
DE2838414C2 (en) 1978-09-02 1984-10-31 Fresenius Ag, 6380 Bad Homburg, De
DE2843756C3 (en) 1978-10-06 1988-05-26 Vaillant, Michael, 4600 Dortmund, De
US4362156A (en) 1979-04-18 1982-12-07 Riverain Corporation Intravenous infusion assembly
FR2487679B1 (en) 1980-08-01 1985-07-12 Hospal Sodip artificial kidney - regulation of the pressure of the dialysis liquid
US4369781A (en) 1981-02-11 1983-01-25 Sherwood Medical Industries Inc. Luer connector
US4731072A (en) 1981-05-11 1988-03-15 Mcneilab, Inc. Apparatus for heating or cooling fluids
US4574876A (en) 1981-05-11 1986-03-11 Extracorporeal Medical Specialties, Inc. Container with tapered walls for heating or cooling fluids
US4411783A (en) 1981-12-23 1983-10-25 Shiley Incorporated Arterial blood filter with improved gas venting
US4441357A (en) 1982-03-04 1984-04-10 Meadox Instruments, Inc. Pressure monitoring and leak detection method and apparatus
US4479762A (en) 1982-12-28 1984-10-30 Baxter Travenol Laboratories, Inc. Prepackaged fluid processing module having pump and valve elements operable in response to applied pressures
US4479760A (en) 1982-12-28 1984-10-30 Baxter Travenol Laboratories, Inc. Actuator apparatus for a prepackaged fluid processing module having pump and valve elements operable in response to applied pressures
DE3378612D1 (en) 1982-12-28 1989-01-12 Baxter Int Prepackaged fluid processing module having pump and valve elements operable in response to applied pressures
US4479761A (en) 1982-12-28 1984-10-30 Baxter Travenol Laboratories, Inc. Actuator apparatus for a prepackaged fluid processing module having pump and valve elements operable in response to externally applied pressures
US4623334A (en) 1983-03-07 1986-11-18 Vanderbilt University Intravenous drug infusion apparatus
DE3328744A1 (en) 1983-08-09 1985-02-28 Fresenius Ag Haemodialysis device
JPS6077782U (en) 1983-11-01 1985-05-30
JPS6311967Y2 (en) * 1983-12-17 1988-04-06
GB2156443B (en) 1984-03-30 1987-04-29 Astra Tech Ab Blood pump
US4664891A (en) 1984-07-23 1987-05-12 Renal Systems, Inc. Dialysis solution preparation from prepackaged dry chemicals
DE3582772D1 (en) 1984-09-06 1991-06-13 Genshiro Ogawa Electronically controlled heater for infusionsfluessigkeiten.
US4718022A (en) 1985-02-21 1988-01-05 Cochran Michael J Dialysis machine which anticipates concentration changes
US4666598A (en) 1985-06-25 1987-05-19 Cobe Laboratories, Inc. Apparatus for use with fluid flow transfer device
US5178182A (en) 1986-03-04 1993-01-12 Deka Products Limited Partnership Valve system with removable fluid interface
US5401342A (en) 1986-03-04 1995-03-28 Deka Products Limited Partnership Process and energy director for ultrasonic welding and joint produced thereby
US5575310A (en) 1986-03-04 1996-11-19 Deka Products Limited Partnership Flow control system with volume-measuring system using a resonatable mass
US4826482A (en) 1986-03-04 1989-05-02 Kamen Dean L Enhanced pressure measurement flow control system
US4778451A (en) 1986-03-04 1988-10-18 Kamen Dean L Flow control system using boyle's law
US4976162A (en) 1987-09-03 1990-12-11 Kamen Dean L Enhanced pressure measurement flow control system
US5074838A (en) 1988-11-07 1991-12-24 Kr Phi Yer Karl K K Extracorporal thermo-therapy device and method for curing diseases using penetrants
US5160325A (en) 1986-10-06 1992-11-03 C. R. Bard, Inc. Catheter with novel lumens shapes
JPH04845Y2 (en) 1986-12-29 1992-01-13
US4784495A (en) 1987-02-06 1988-11-15 Gambro Ab System for preparing a fluid intended for a medical procedure by mixing at least one concentrate in powder form with water
JPS63315060A (en) 1987-03-17 1988-12-22 Aasaa Roogan Kenesu Disposable pump element for pump apparatus
US4927411A (en) 1987-05-01 1990-05-22 Abbott Laboratories Drive mechanism for disposable fluid infusion pumping cassette
NL8701233A (en) 1987-05-22 1988-12-16 Medistad Holland Blood Warmer.
JP2513243B2 (en) 1987-07-24 1996-07-03 東洋紡績株式会社 Blood pump
US5088515A (en) 1989-05-01 1992-02-18 Kamen Dean L Valve system with removable fluid interface
US4822343A (en) 1987-09-21 1989-04-18 Louise Beiser Blood collection device with ejectable tips
DE3734072C2 (en) * 1987-10-08 1990-07-12 Liba Maschinenfabrik Gmbh, 8674 Naila, De
US4781535A (en) 1987-11-13 1988-11-01 Pulsafeeder, Inc. Apparatus and method for sensing diaphragm failures in reciprocating pumps
EP0544653B1 (en) 1988-01-25 1996-06-05 Baxter International Inc. Injection site
ES2055750T3 (en) 1988-03-03 1994-09-01 Gambro Ab Dialysis system.
US4863461A (en) 1988-03-21 1989-09-05 Symbion, Inc. Artificial ventricle
EP0336993B1 (en) * 1988-04-13 1993-07-21 Med-Tech Inc. Method of controlling amount of removed water by ultrafiltration and control device for controlling amount of removed water by ultrafiltration in hemodialysis
US4950235A (en) 1988-05-10 1990-08-21 Pacesetter Infusion, Ltd. Container-side occlusion detection system for a medication infusion system
US4976729A (en) 1988-08-15 1990-12-11 University Of Utah Research Foundation Elliptical artificial heart
US5110447A (en) * 1988-09-12 1992-05-05 Kasten, Eadie Technology Ltd. Process and apparatus for partial upgrading of a heavy oil feedstock
DE3837498C2 (en) * 1988-11-04 1990-10-18 Fresenius Ag, 6380 Bad Homburg, De
DE3907735A1 (en) 1989-03-10 1990-09-20 Bran & Luebbe Diaphragm pump with free-swinging metal membrane
CA2027591C (en) 1989-03-17 1996-02-27 Steven C. Jepson Pre-slit injection site and tapered cannula
US5167837A (en) 1989-03-28 1992-12-01 Fas-Technologies, Inc. Filtering and dispensing system with independently activated pumps in series
US5702371A (en) 1989-07-24 1997-12-30 Venetec International, Inc. Tube fitting anchoring system
US5423738A (en) 1992-03-13 1995-06-13 Robinson; Thomas C. Blood pumping and processing system
US5242384A (en) 1989-11-13 1993-09-07 Davol, Inc. Blood pumping and processing system
DE3938662C2 (en) 1989-11-21 1992-05-27 Fresenius Ag, 6380 Bad Homburg, De
US5062774A (en) 1989-12-01 1991-11-05 Abbott Laboratories Solution pumping system including disposable pump cassette
US5125069A (en) 1989-12-22 1992-06-23 Netherlands Health Sciences Blood warmer
US5278072A (en) 1990-04-26 1994-01-11 Minnesota Mining And Manufacturing Company Calibration system and housing
GB2248927B (en) 1990-10-17 1994-04-20 Danby Medical Ltd A device for detecting air in fluid conducting tubing
US5098262A (en) 1990-12-28 1992-03-24 Abbott Laboratories Solution pumping system with compressible pump cassette
US5116316A (en) 1991-02-25 1992-05-26 Baxter International Inc. Automatic in-line reconstitution system
US5381510A (en) 1991-03-15 1995-01-10 In-Touch Products Co. In-line fluid heating apparatus with gradation of heat energy from inlet to outlet
US5245693A (en) 1991-03-15 1993-09-14 In-Touch Products Co. Parenteral fluid warmer apparatus and disposable cassette utilizing thin, flexible heat-exchange membrane
US5486286A (en) 1991-04-19 1996-01-23 Althin Medical, Inc. Apparatus for performing a self-test of kidney dialysis membrane
EP0668793B1 (en) 1992-11-12 2000-04-05 Althin Medical Inc. Apparatus for kidney dialysis
US5326476A (en) 1991-04-19 1994-07-05 Althin Medical, Inc. Method and apparatus for kidney dialysis using machine with programmable memory
US5247434A (en) 1991-04-19 1993-09-21 Althin Medical, Inc. Method and apparatus for kidney dialysis
US5902476A (en) 1991-08-21 1999-05-11 Twardowski; Zbylut J. Artificial kidney for frequent (daily) hemodialysis
US5336165A (en) 1991-08-21 1994-08-09 Twardowski Zbylut J Artificial kidney for frequent (daily) Hemodialysis
US6165154A (en) 1995-06-07 2000-12-26 Deka Products Limited Partnership Cassette for intravenous-line flow-control system
WO1993012825A1 (en) * 1991-12-20 1993-07-08 Abbott Laboratories Automated drug infusion system with autopriming
CA2101537C (en) 1991-12-30 2002-05-14 Andrea Rossi Dialysis machine with safety monitoring and a corresponding method for monitoring safety
US5267956A (en) 1992-02-05 1993-12-07 Alcon Surgical, Inc. Surgical cassette
US5616248A (en) 1992-04-06 1997-04-01 Schal; Wilfried Method for the preparation of hemodialysis fluids containing bicarbonate
US5302093A (en) 1992-05-01 1994-04-12 Mcgaw, Inc. Disposable cassette with negative head height fluid supply and method
US5704520A (en) * 1993-07-19 1998-01-06 Elan Medical Technologies, Limited Liquid material dispenser and valve
US5476368A (en) 1992-08-20 1995-12-19 Ryder International Corporation Sterile fluid pump diaphragm construction
US5476444A (en) 1992-09-04 1995-12-19 Idt, Inc. Specialized perfusion protocol for whole-body hyperthermia
US5568362A (en) 1992-09-25 1996-10-22 Atlas Copco Tools Ab Cabinet for housing electronic equipment connectable to machines or power tools for performing operations
US5274245A (en) 1992-11-06 1993-12-28 Lee Thomas E Optical liquid level detector using dual varying light emitters
DE4336336A1 (en) 1992-11-23 1994-05-26 Lang Volker Kasetteninfusionssystem
DE4239937C2 (en) 1992-11-27 1995-08-24 Fresenius Ag Procedure for determining the operability of a partial device of a hemodialysis machine, and device for carrying out this method
US5306242A (en) * 1992-12-15 1994-04-26 Abbott Laboratories Recirculation through plural pump cassettes for a solution compounding apparatus
GB2273533B (en) 1992-12-18 1996-09-25 Minnesota Mining & Mfg Pumping cassette with integral manifold
CA2145295A1 (en) 1992-12-30 1994-07-21 Kent D. Abrahamson Diaphragm for solution pumping system
US5362383A (en) 1993-01-13 1994-11-08 Ecowater Systems, Inc. Self-contained reverse osmosis electronic monitoring system
US5431626A (en) 1993-03-03 1995-07-11 Deka Products Limited Partnership Liquid pumping mechanisms for peritoneal dialysis systems employing fluid pressure
US5324422A (en) 1993-03-03 1994-06-28 Baxter International Inc. User interface for automated peritoneal dialysis systems
DE69413166T2 (en) * 1993-03-03 1999-05-12 Deka Products Lp Device for peritonaldialyse equipped with a Liquid distribution for air separation and pumping cartridge.
US5350357A (en) 1993-03-03 1994-09-27 Deka Products Limited Partnership Peritoneal dialysis systems employing a liquid distribution and pumping cassette that emulates gravity flow
US5438510A (en) 1993-03-03 1995-08-01 Deka Products Limited Partnership User interface and monitoring functions for automated peritoneal dialysis systems
US5474683A (en) 1993-03-03 1995-12-12 Deka Products Limited Partnership Peritoneal dialysis systems and methods employing pneumatic pressure and temperature-corrected liquid volume measurements
US5413566A (en) 1993-03-16 1995-05-09 Micropump Corporation Line clamp
US5410255A (en) 1993-05-07 1995-04-25 Perma-Pipe, Inc. Method and apparatus for detecting and distinguishing leaks using reflectometry and conductivity tests
US5645531A (en) 1993-05-26 1997-07-08 Quest Medical, Inc. Constant pressure blood mixture delivery system and method
JP2576760B2 (en) 1993-06-08 1997-01-29 日本電気株式会社 Micro field emission cold cathode and a manufacturing method thereof
US5349896A (en) 1993-06-14 1994-09-27 W. L. Gore & Associates, Inc. Pump diaphragm
US5398851A (en) 1993-08-06 1995-03-21 River Medical, Inc. Liquid delivery device
US5395316A (en) 1993-08-11 1995-03-07 Med-Pro Design, Inc. Triple lumen catheter
JP2912801B2 (en) * 1993-10-06 1999-06-28 旭メディカル株式会社 Hemodialysis apparatus
US5420962A (en) 1993-10-25 1995-05-30 Bakke; Allan P. Convection blood warming system with disposable flattened tube envelope having vent incorporating a hydrophobic filter
GB9325591D0 (en) 1993-12-14 1994-02-16 Somerset Technical Lab Ltd Leakage detection
US5480294A (en) * 1993-12-22 1996-01-02 Baxter International Inc. Peristaltic pump module having jaws for gripping a peristaltic pump tube cassett
US5462416A (en) * 1993-12-22 1995-10-31 Baxter International Inc. Peristaltic pump tube cassette for blood processing systems
US5482440A (en) 1993-12-22 1996-01-09 Baxter Int Blood processing systems using a peristaltic pump module with valve and sensing station for operating a peristaltic pump tube cassette
US5427509A (en) * 1993-12-22 1995-06-27 Baxter International Inc. Peristaltic pump tube cassette with angle pump tube connectors
US5680111A (en) 1994-02-05 1997-10-21 Baxter International Inc. Dual sensor air-in-line detector
US5460619A (en) 1994-04-04 1995-10-24 Esrock; Bernard S. Disposable tubular device and method
US5441231A (en) 1994-05-17 1995-08-15 Payne; Barrett M. M. Valve closing actuator
DE4421126A1 (en) 1994-06-16 1995-12-21 Fresenius Ag peritoneal dialysis
FR2723002B1 (en) 1994-07-26 1996-09-06 Hospal Ind Device and process for preparing a filtration treatment liquid
US5581687A (en) 1994-11-10 1996-12-03 Baxter International Inc. Interactive control systems for medical processing devices
US5593290A (en) 1994-12-22 1997-01-14 Eastman Kodak Company Micro dispensing positive displacement pump
US5755275A (en) 1995-01-25 1998-05-26 Delta Temax Inc. Tubed lamination heat transfer articles and method of manufacture
US5932103A (en) 1995-02-13 1999-08-03 Aksys, Ltd. Withdrawal of priming fluid from extracorporeal circuit of hemodialysis machines or the like
US6153102A (en) 1995-02-13 2000-11-28 Aksys, Ltd. Disinfection of dead-ended lines in medical instruments
US5932110A (en) 1995-02-13 1999-08-03 Aksys, Ltd. Dialysate conductivity adjustment in a batch dialysate preparation system
WO1996025189A1 (en) 1995-02-15 1996-08-22 Astra Aktiebolag Pump chamber and valve for a pump chamber
US6044868A (en) 1995-02-24 2000-04-04 Arlington Industries, Inc. Watertight fitting for flexible non-metallic conduit
US5640995A (en) * 1995-03-14 1997-06-24 Baxter International Inc. Electrofluidic standard module and custom circuit board assembly
US5586438A (en) 1995-03-27 1996-12-24 Organ, Inc. Portable device for preserving organs by static storage or perfusion
US5578012A (en) 1995-04-24 1996-11-26 Deka Products Limited Partnership Medical fluid pump
US5839715A (en) 1995-05-16 1998-11-24 Alaris Medical Systems, Inc. Medical adapter having needleless valve and sharpened cannula
US6709417B1 (en) 1995-06-07 2004-03-23 Deka Products Limited Partnership Valve for intravenous-line flow-control system
US5755683A (en) 1995-06-07 1998-05-26 Deka Products Limited Partnership Stopcock valve
US5729653A (en) 1995-06-07 1998-03-17 Urosurge, Inc. Fluid warming system
US5609770A (en) 1995-06-07 1997-03-11 Cobe Laboratories, Inc. Graphical operator machine interface and method for information entry and selection in a dialysis machine
US5676644A (en) 1995-06-07 1997-10-14 Cobe Laboratories, Inc. Extracorporeal blood processing methods and apparatus
US5650071A (en) 1995-06-07 1997-07-22 Cobe Laboratories, Inc. Technique for priming and recirculating fluid through a dialysis machine to prepare the machine for use
US5772624A (en) 1995-07-20 1998-06-30 Medisystems Technology Corporation Reusable blood lines
US5776098A (en) 1995-08-03 1998-07-07 Medela, Incorporated Diaphragm pump and pump mounted in a carrying case useful in breast pumping
US5730720A (en) 1995-08-18 1998-03-24 Ip Scientific, Inc. Perfusion hyperthermia treatment system and method
US5674190A (en) 1995-08-28 1997-10-07 Organetics, Ltd. Extracorporeal whole body hyperthermia using alpha-stat regulation of blood pH and pCO2
US5938634A (en) * 1995-09-08 1999-08-17 Baxter International Inc. Peritoneal dialysis system with variable pressure drive
US5674109A (en) 1995-09-13 1997-10-07 Ebara Corporation Apparatus and method for polishing workpiece
US6331778B1 (en) 1995-09-27 2001-12-18 Leak Location Services, Inc. Methods for detecting and locating leaks in containment facilities using electrical potential data and electrical resistance tomographic imaging techniques
JPH0999060A (en) 1995-10-04 1997-04-15 Terumo Corp Pulsatile blood pump
US5638737A (en) 1995-11-27 1997-06-17 Quest Medical, Inc. Spline pumping assembly
CA2186805C (en) 1995-12-01 2001-03-27 Christopher C. Jung Apparatus and method for sensing fluid level
GB9607471D0 (en) 1996-04-10 1996-06-12 Baxter Int Volumetric infusion pump
US6146354A (en) 1996-05-24 2000-11-14 Horizon Medical Products Asymmetrical multi-lumen apheresis catheter with balanced flow rates
JPH09327511A (en) * 1996-06-12 1997-12-22 A S A Sangyo Kk Method for recovering and regenerating peritoneal dialysis liquid and treating device and ancillary appliance for this purpose
US6783328B2 (en) 1996-09-30 2004-08-31 Terumo Cardiovascular Systems Corporation Method and apparatus for controlling fluid pumps
US6047108A (en) 1996-10-01 2000-04-04 Baxter International Inc. Blood warming apparatus
US5875282A (en) 1996-10-21 1999-02-23 Gaymar Industries, Inc. Medical apparatus for warming patient fluids
WO1998019529A1 (en) 1996-11-07 1998-05-14 21St Century Medicine, Inc. A method for rapid cooling and warming of biological materials
US5882047A (en) 1996-12-20 1999-03-16 Itt Automotive, Inc. Quick connector fluid coupling
US6852090B2 (en) 1997-02-14 2005-02-08 Nxstage Medical, Inc. Fluid processing systems and methods using extracorporeal fluid flow panels oriented within a cartridge
US6638478B1 (en) 1997-02-14 2003-10-28 Nxstage Medical, Inc. Synchronized volumetric fluid balancing systems and methods
US6579253B1 (en) 1997-02-14 2003-06-17 Nxstage Medical, Inc. Fluid processing systems and methods using extracorporeal fluid flow panels oriented within a cartridge
US7147613B2 (en) 1997-02-14 2006-12-12 Nxstage Medical, Inc. Measurement of fluid pressure in a blood treatment device
JP4416368B2 (en) 1997-02-14 2010-02-17 ネクステージ メディカル インコーポレイテッド Fluid processing apparatus and method using an extracorporeal fluid flow panel disposed in the cartridge
US6673314B1 (en) 1997-02-14 2004-01-06 Nxstage Medical, Inc. Interactive systems and methods for supporting hemofiltration therapies
US6419462B1 (en) 1997-02-24 2002-07-16 Ebara Corporation Positive displacement type liquid-delivery apparatus
WO1998037801A1 (en) 1997-02-27 1998-09-03 Minnesota Mining And Manufacturing Company Cassette for measuring parameters of blood
DE19708391C1 (en) * 1997-03-01 1998-10-22 Fresenius Medical Care De Gmbh Method and apparatus for ultrafiltration during hemodialysis
US5899873A (en) 1997-03-24 1999-05-04 Quest Medical, Inc. Biological fluid delivery system
US6660974B2 (en) 1997-04-07 2003-12-09 Medical Solutions, Inc. Warming system and method for heating various items utilized in surgical procedures
EP0994739B1 (en) 1997-07-09 2005-09-28 Gambro Lundia AB Method and arrangement for integrity-testing of a tube-set for use in a cycler for peritoneal dialysis
US6070761A (en) 1997-08-22 2000-06-06 Deka Products Limited Partnership Vial loading method and apparatus for intelligent admixture and delivery of intravenous drugs
US6090092A (en) 1997-12-04 2000-07-18 Baxter International Inc. Sliding reconstitution device with seal
US6109881A (en) 1998-01-09 2000-08-29 Snodgrass; Ocie T. Gas driven pump for the dispensing and filtering of process fluid
JPH11210633A (en) 1998-01-30 1999-08-03 Matsushita Electric Works Ltd Suction device
US6142164A (en) 1998-03-09 2000-11-07 Ultra Clean Technology Systems & Service, Inc. Method and apparatus for removing leaking gas in an integrated gas panel system
DE19814695C2 (en) 1998-04-01 2001-09-13 Fresenius Medical Care De Gmbh Cassette for conveying liquids, in particular dialysis fluids, dialysis apparatus and method for conveying, accounted for, and dispensing of medical fluid heating
US6343614B1 (en) 1998-07-01 2002-02-05 Deka Products Limited Partnership System for measuring change in fluid flow rate within a line
US6041801A (en) 1998-07-01 2000-03-28 Deka Products Limited Partnership System and method for measuring when fluid has stopped flowing within a line
US6175688B1 (en) 1998-07-10 2001-01-16 Belmont Instrument Corporation Wearable intravenous fluid heater
DE69934125D1 (en) 1998-09-10 2007-01-04 Gambro Ab Device for monitoring a fluid line
JP2000107283A (en) * 1998-10-07 2000-04-18 Nissho Corp Dialysis apparatus and washing priming method
US6695803B1 (en) 1998-10-16 2004-02-24 Mission Medical, Inc. Blood processing system
US6223130B1 (en) 1998-11-16 2001-04-24 Deka Products Limited Partnership Apparatus and method for detection of a leak in a membrane of a fluid flow control system
CN2374187Y (en) 1999-01-29 2000-04-19 暨南大学 Blood dialyser
DE19906317C1 (en) 1999-02-16 2000-10-19 Knf Flodos Ag Sursee diaphragm pump
DE60000728T2 (en) 1999-03-09 2003-08-21 Augustine Medical Inc A means for heating IV fluid with detecting the presence and alignment of a cassette
WO2000057928A1 (en) 1999-03-30 2000-10-05 Gambro Lundia Ab Method and apparatus for sterilising a heat sensitive fluid
WO2000057935A1 (en) 1999-03-30 2000-10-05 Gambro Lundia Ab Method, apparatus and components of dialysis system
US6579496B1 (en) 1999-05-25 2003-06-17 Viacirq, Inc. Apparatus for implementing hyperthermia
US6321597B1 (en) 1999-05-28 2001-11-27 Deka Products Limited Partnership System and method for measuring volume of liquid in a chamber
US7168334B1 (en) 2000-05-30 2007-01-30 Gambro Lundia Ab Arrangement for measuring a property of a fluid present in a tube
DE19925297C1 (en) 1999-06-02 2000-07-13 Braun Melsungen Ag Dialysis machine filter cartridge holder uses radial tensioner elements to seal onto cartridge connections when positioned using keyhole holder connections taking cartridge connection grooves.
US6406452B1 (en) 1999-06-16 2002-06-18 First Circle Medical, Inc. Bladder catheter for hyperthermia system
US6336911B1 (en) 1999-06-16 2002-01-08 First Circle Medical, Inc. Thermal sensor for hyperthermia system
DE19928407C1 (en) 1999-06-22 2000-10-26 Fresenius Medical Care De Gmbh Determining dialyser performance in dialysis device involves determining clearance and dialysance based on values for given blood/dialysis liquid flow rates and/or ultrafiltration rate
US6416293B1 (en) 1999-07-20 2002-07-09 Deka Products Limited Partnership Pumping cartridge including a bypass valve and method for directing flow in a pumping cartridge
US6302653B1 (en) 1999-07-20 2001-10-16 Deka Products Limited Partnership Methods and systems for detecting the presence of a gas in a pump and preventing a gas from being pumped from a pump
US6604908B1 (en) * 1999-07-20 2003-08-12 Deka Products Limited Partnership Methods and systems for pulsed delivery of fluids from a pump
US6905479B1 (en) 1999-07-20 2005-06-14 Deka Products Limited Partnership Pumping cartridge having an integrated filter and method for filtering a fluid with the cartridge
JP2004515231A (en) * 2000-11-03 2004-05-27 クリニカル・マイクロ・センサーズ・インコーポレイテッドClinical Micro Sensors, Inc. Apparatus and method for multiplexing a biochip
US6261065B1 (en) 1999-09-03 2001-07-17 Baxter International Inc. System and methods for control of pumps employing electrical field sensing
US6949079B1 (en) 1999-09-03 2005-09-27 Baxter International Inc. Programmable, fluid pressure actuated blood processing systems and methods
US6284142B1 (en) 1999-09-03 2001-09-04 Baxter International Inc. Sensing systems and methods for differentiating between different cellular blood species during extracorporeal blood separation or processing
EP1129290B1 (en) * 1999-09-03 2011-10-19 Fenwal, Inc. Systems and methods for control of pumps
US20060178612A9 (en) 1999-09-03 2006-08-10 Baxter International Inc. Blood processing systems with fluid flow cassette with a pressure actuated pump chamber and in-line air trap
US6270673B1 (en) 1999-09-03 2001-08-07 Baxter International Inc. Door latching assembly for holding a fluid pressure actuated cassette during use
JP3806859B2 (en) 1999-09-24 2006-08-09 応研精工株式会社 Diaphragm pump
US6464666B1 (en) 1999-10-08 2002-10-15 Augustine Medical, Inc. Intravenous fluid warming cassette with stiffening member and integral handle
US6295918B1 (en) 1999-10-15 2001-10-02 John M. Simmons Suspended diaphragm
US6406426B1 (en) 1999-11-03 2002-06-18 Criticare Systems Medical monitoring and alert system for use with therapeutic devices
US6423053B1 (en) 2000-01-12 2002-07-23 Han-Pin Lee Releasable tube assembly
US6347633B1 (en) 2000-01-14 2002-02-19 First Circle Medical, Inc. Treatment of hepatitis C using hyperthermia
US6497676B1 (en) 2000-02-10 2002-12-24 Baxter International Method and apparatus for monitoring and controlling peritoneal dialysis therapy
EP1177801A1 (en) 2000-02-16 2002-02-06 Teijin Limited Dialyzing fluid preparing device and powdery dialyzing fluid preparing chemical
JP4717312B2 (en) 2000-02-29 2011-07-06 ジェン−プローブ・インコーポレイテッドGen−Probe Incorporated Fluid delivery probe
US6595944B2 (en) 2000-06-17 2003-07-22 Fresenius Medical Care Deutschland Gmbh Dialysis machine and method of operating a dialysis machine
US6517510B1 (en) 2000-06-26 2003-02-11 Gaymar Industries, Inc. Automatic patient control device
US6415797B1 (en) 2000-07-07 2002-07-09 First Circle Medical, Inc. Treatment of human herpesviruses using hyperthermia
WO2002003879A1 (en) 2000-07-07 2002-01-17 First Circle Medical, Inc. Treatment of hiv using hyperthermia
US6503062B1 (en) 2000-07-10 2003-01-07 Deka Products Limited Partnership Method for regulating fluid pump pressure
US6899693B2 (en) 2000-08-08 2005-05-31 Dideco S.P.A. Pulsating pumping unit for a fluid, particularly blood
US6336003B1 (en) 2000-09-01 2002-01-01 Automatic Medical Technologies, Inc. Max one I.V. warmer
US6788885B2 (en) 2000-09-01 2004-09-07 Michael Mitsunaga System for heating instillation or transfusion liquids
DE10046651A1 (en) 2000-09-20 2002-04-04 Fresenius Medical Care De Gmbh Valve
ES2284685T3 (en) 2000-09-29 2007-11-16 Gambro Dasco, S.P.A. Dialysis machine and method of checking operation of a dialysis machine.
US6785934B2 (en) 2000-10-02 2004-09-07 Cornice Technologies Inc Universal vacuum extension kit
JP4643815B2 (en) * 2000-10-04 2011-03-02 テルモ株式会社 Peritoneal dialysis equipment
CA2425548C (en) 2000-10-12 2009-02-10 Stephen R. Ash Devices and methods for body fluid flow control in extracorporeal fluid treatments
US6468241B1 (en) 2000-10-26 2002-10-22 Chf Solutions, Inc. Artificial kidney set with electronic key
DE10053441B4 (en) 2000-10-27 2004-04-15 Fresenius Medical Care Deutschland Gmbh Disposable cartridge with sealing membrane and valve actuator for this purpose
US6689083B1 (en) 2000-11-27 2004-02-10 Chf Solutions, Inc. Controller for ultrafiltration blood circuit which prevents hypotension by monitoring osmotic pressure in blood
US6814718B2 (en) 2001-01-09 2004-11-09 Rex Medical, L.P Dialysis catheter
US6529775B2 (en) 2001-01-16 2003-03-04 Alsius Corporation System and method employing indwelling RF catheter for systemic patient warming by application of dielectric heating
US6539172B2 (en) 2001-01-31 2003-03-25 Kabushiki Kaisha Sanko Fluid heating device and cartridge for the same
EP1399193B1 (en) 2001-02-16 2014-01-08 Piedmont Renal Clinics, P.A. Automated peritoneal dialysis system and process with in-line sterilization of dialysate
US6531708B1 (en) 2001-04-16 2003-03-11 Zevex, Inc. Optical bubble detection system
DE10126134B4 (en) 2001-05-29 2004-02-26 W.E.T. Automotive Systems Ag Large-area heating element
US6527758B2 (en) 2001-06-11 2003-03-04 Kam Ko Vial docking station for sliding reconstitution with diluent container
US7641864B2 (en) 2001-06-15 2010-01-05 Avure Technologies Incorporated Thermal sensor connector for pressure vessel
US6768085B2 (en) 2001-07-02 2004-07-27 Medical Solutions, Inc. Medical solution warming system and method of heating and maintaining medical solutions at desired temperatures
EP1453592B1 (en) 2001-07-16 2009-12-23 Miox Corporation Dual head pump driven membrane system
US6722865B2 (en) 2001-09-07 2004-04-20 Terumorcardiovascular Systems Corporation Universal tube clamp assembly
US6868309B1 (en) 2001-09-24 2005-03-15 Aksys, Ltd. Dialysis machine with symmetric multi-processing (SMP) control system and method of operation
US6905314B2 (en) 2001-10-16 2005-06-14 Baxter International Inc. Pump having flexible liner and compounding apparatus having such a pump
US7241272B2 (en) 2001-11-13 2007-07-10 Baxter International Inc. Method and composition for removing uremic toxins in dialysis processes
US7645253B2 (en) 2001-11-16 2010-01-12 National Quality Care, Inc. Wearable ultrafiltration device
US7854718B2 (en) 2001-11-16 2010-12-21 Fresenius Medical Care Holdings, Inc. Dual-ventricle pump cartridge, pump and method of use in a wearable continuous renal replacement therapy device
US6608968B2 (en) 2001-11-23 2003-08-19 Allan P Bakke Convection blood warming system with disposable flattened tube envelope incorporating paperboard “needle” for inserting envelope between heating plates and employing active and passive insulation of outlet flow path to provide normothermic fluid at zero to 600 milliliters per minute
US8226605B2 (en) 2001-12-17 2012-07-24 Medical Solutions, Inc. Method and apparatus for heating solutions within intravenous lines to desired temperatures during infusion
ES2303559T3 (en) 2001-12-28 2008-08-16 Gambro Lundia Ab Control equipment in an extracorporeal blood circuit.
US7122210B2 (en) 2002-01-11 2006-10-17 Baxter International Inc. Bicarbonate-based solutions for dialysis therapies
US7107837B2 (en) * 2002-01-22 2006-09-19 Baxter International Inc. Capacitance fluid volume measurement
US6692457B2 (en) 2002-03-01 2004-02-17 Insulet Corporation Flow condition sensor assembly for patient infusion device
JP2003265599A (en) 2002-03-15 2003-09-24 Nextier:Kk Hemocatharsis system
DE10212247C1 (en) * 2002-03-19 2003-12-18 Fresenius Medical Care De Gmbh A method for determining a treatment parameter at a hemofiltration and hemofiltration apparatus for applying the method
WO2003080268A1 (en) 2002-03-27 2003-10-02 Lazer Safe Pty Ltd. Multiple laser safety system
US7052480B2 (en) 2002-04-10 2006-05-30 Baxter International Inc. Access disconnection systems and methods
US7138088B2 (en) 2002-04-10 2006-11-21 Baxter International Inc. Access disconnection system and methods
US7544179B2 (en) 2002-04-11 2009-06-09 Deka Products Limited Partnership System and method for delivering a target volume of fluid
DE10216146A1 (en) 2002-04-12 2003-10-30 Bayer Ag diaphragm pump
US20040136843A1 (en) * 2002-04-12 2004-07-15 Bayer Aktiengesellschaft Diaphragm pump
US7029245B2 (en) 2002-05-14 2006-04-18 Sorin Group Italia S.R.L. Blood pumping unit, with a coplanar disk inlet valve and an annular outlet valve
EP2260889A3 (en) * 2002-05-24 2013-01-23 Baxter International Inc. Automated dialysis system
US6929751B2 (en) 2002-05-24 2005-08-16 Baxter International Inc. Vented medical fluid tip protector methods
JP4468801B2 (en) 2002-05-24 2010-05-26 バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated Hardware system for automated dialysis machine, method and apparatus
DE10224750A1 (en) * 2002-06-04 2003-12-24 Fresenius Medical Care De Gmbh An apparatus for treating a medical fluid
US20050209547A1 (en) 2002-06-06 2005-09-22 Burbank Jeffrey H Last-chance quality check and/or air/pathogen filter for infusion systems
US20040009096A1 (en) 2002-06-08 2004-01-15 Wellman Parris S. Substantially inertia free hemodialysis
JP3971659B2 (en) * 2002-06-14 2007-09-05 日機装株式会社 Dialysate supply device
DE10227193B4 (en) 2002-06-18 2007-05-10 Ulman Dichtungstechnik Gmbh Composite membrane for diaphragm pumps
DE10227192B4 (en) 2002-06-18 2009-08-06 Ulman Dichtungstechnik Gmbh Composite membrane for diaphragm pumps
US7238164B2 (en) 2002-07-19 2007-07-03 Baxter International Inc. Systems, methods and apparatuses for pumping cassette-based therapies
JP4066242B2 (en) * 2002-07-25 2008-03-26 テルモ株式会社 Peritoneal dialysis apparatus and control method thereof
US7175397B2 (en) 2002-09-27 2007-02-13 Pulsafeeder, Inc. Effervescent gas bleeder apparatus
US20040138607A1 (en) 2002-10-08 2004-07-15 Burbank Jeffrey H. Cartridge-based medical fluid processing system
WO2004041081A1 (en) 2002-11-01 2004-05-21 Nxstage Medical, Inc. Functional isolation of upgradeable components to reduce risk in medical treatment devices
DE10256923B4 (en) 2002-12-05 2013-10-24 Liebherr-France S.A. Method and apparatus for damping the movement of hydraulic cylinders of mobile working machines
US7232418B2 (en) 2003-02-07 2007-06-19 Gambro Lundia Ab Support element, an integrated module for extracorporeal blood treatment comprising the support element, an apparatus for extracorporeal blood treatment equipped with the integrated module, and an assembly process for an integrated module for extracorporeal blood treatment
WO2004105589A3 (en) 2003-05-28 2005-06-23 Hemocleanse Technologies Llc Sorbent reactor for extracorporeal blood treatment systems, peritoneal dialysis systems, and other body fluid treatment systems
JP4286073B2 (en) 2003-06-18 2009-06-24 ニプロ株式会社 Dialyzer connecting coupler
JP4041018B2 (en) * 2003-06-25 2008-01-30 Tdk株式会社 Temperature sensor
US7727220B2 (en) 2003-08-15 2010-06-01 Gambro Lundia Ab Connecting device, a medical system, and a method of connecting medical subsystems
GB0321058D0 (en) * 2003-09-09 2003-10-08 Qinetiq Ltd Sensor and sensor array for monitoring a structure
JP4732726B2 (en) 2003-09-09 2011-07-27 セイコーインスツル株式会社 A method of manufacturing a semiconductor device
US6826948B1 (en) 2003-10-09 2004-12-07 Delphi Technologies, Inc. Leak detection apparatus for a liquid circulation cooling system
US8500676B2 (en) 2003-10-13 2013-08-06 Fresenius Medical Care Deutschland Gmbh Device for carrying out a peritoneal dialysis treatment
US7029456B2 (en) 2003-10-15 2006-04-18 Baxter International Inc. Medical fluid therapy flow balancing and synchronization system
JP4691503B2 (en) * 2003-10-28 2011-06-01 バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated For medical fluid system, improved priming method and apparatus integrity and hydraulic head height
US7776006B2 (en) 2003-11-05 2010-08-17 Baxter International Inc. Medical fluid pumping system having real time volume determination
US8038639B2 (en) 2004-11-04 2011-10-18 Baxter International Inc. Medical fluid system with flexible sheeting disposable unit
US8029454B2 (en) 2003-11-05 2011-10-04 Baxter International Inc. High convection home hemodialysis/hemofiltration and sorbent system
US7744553B2 (en) 2003-12-16 2010-06-29 Baxter International Inc. Medical fluid therapy flow control systems and methods
US8672875B2 (en) 2003-12-31 2014-03-18 Carefusion 303, Inc. Medication safety enhancement for secondary infusion
CA2554508A1 (en) 2004-01-21 2005-08-04 Imi Vision Limited Fluid metering with a disposable membrane type pump unit
CA2496646A1 (en) 2004-02-12 2005-08-12 Flowtec Medical Inc. Fluid monitoring device
JP2005253747A (en) * 2004-03-12 2005-09-22 Japan Science & Technology Agency Blood purification device and its replaceable blood purification device unit
US20050209563A1 (en) 2004-03-19 2005-09-22 Peter Hopping Cassette-based dialysis medical fluid therapy systems, apparatuses and methods
US7407443B2 (en) * 2004-09-07 2008-08-05 Nike, Inc. Structure of a golf club head or other ball striking device
US7476209B2 (en) * 2004-12-21 2009-01-13 Therakos, Inc. Method and apparatus for collecting a blood component and performing a photopheresis treatment
GB0501579D0 (en) 2005-01-25 2005-03-02 Spaceace Ltd Safety mechanism
JP2006204343A (en) 2005-01-25 2006-08-10 Hiroshima Univ Auxiliary artificial heart
JP2006218130A (en) 2005-02-10 2006-08-24 Terumo Corp Peritoneal dialysis, dialysate set and peritoneal dialyzer control method
CA2598486C (en) 2005-02-16 2014-03-25 Triomed Ab System and method for regeneration of a fluid
US7935074B2 (en) * 2005-02-28 2011-05-03 Fresenius Medical Care Holdings, Inc. Cassette system for peritoneal dialysis machine
US20060195064A1 (en) 2005-02-28 2006-08-31 Fresenius Medical Care Holdings, Inc. Portable apparatus for peritoneal dialysis therapy
US7563248B2 (en) 2005-03-17 2009-07-21 Smisson-Cartledge Biomedical Llc Infusion fluid heat exchanger and cartridge
WO2006120417A3 (en) * 2005-05-06 2007-01-18 Imi Vision Ltd Fluid processing apparatus
DE102005024363B4 (en) 2005-05-27 2012-09-20 Fresenius Medical Care Deutschland Gmbh Apparatus and method for conveying liquids
US7717682B2 (en) 2005-07-13 2010-05-18 Purity Solutions Llc Double diaphragm pump and related methods
US8197231B2 (en) * 2005-07-13 2012-06-12 Purity Solutions Llc Diaphragm pump and related methods
US7857506B2 (en) 2005-12-05 2010-12-28 Sencal Llc Disposable, pre-calibrated, pre-validated sensors for use in bio-processing applications
US20070179436A1 (en) 2005-12-21 2007-08-02 Braig James R Analyte detection system with periodic sample draw and laboratory-grade analyzer
JP2007215557A (en) 2006-02-14 2007-08-30 Kawasumi Lab Inc Detachable extracorporeal circulation circuit
DE602007008395D1 (en) 2006-04-07 2010-09-23 Nxstage Medical Inc Hose clamp for medical applications
CN100460026C (en) 2006-04-12 2009-02-11 重庆山外山科技有限公司 Medical hemodialysis filter
US8366316B2 (en) 2006-04-14 2013-02-05 Deka Products Limited Partnership Sensor apparatus systems, devices and methods
EP2012848A4 (en) 2006-04-27 2013-12-25 Gambro Lundia Ab Remote controlled medical apparatus
US20080287854A1 (en) 2006-06-24 2008-11-20 Jiandong Sun Emergency-Disengagement Device for Patients Undergoing Hemodialysis
WO2008010004A1 (en) 2006-07-14 2008-01-24 Gambro Lundia Ab Blood processing apparatus
US8926550B2 (en) 2006-08-31 2015-01-06 Fresenius Medical Care Holdings, Inc. Data communication system for peritoneal dialysis machine
US8870811B2 (en) 2006-08-31 2014-10-28 Fresenius Medical Care Holdings, Inc. Peritoneal dialysis systems and related methods
US20080058712A1 (en) 2006-08-31 2008-03-06 Plahey Kulwinder S Peritoneal dialysis machine with dual voltage heater circuit and method of operation
DE102006042336A1 (en) 2006-09-08 2008-03-27 Fresenius Medical Care Deutschland Gmbh Apparatus and method for monitoring an access to a patient, in particular a vascular access in extracorporeal blood treatment
FR2907259A1 (en) 2006-10-13 2008-04-18 St Microelectronics Sa Realization of a metal gate in an electronic circuit integrated
JP2008104737A (en) 2006-10-26 2008-05-08 Terumo Corp Peritoneal dialyzer
CN101206517B (en) 2006-12-22 2011-06-22 奇美电子股份有限公司 Computer
US20080161751A1 (en) 2006-12-29 2008-07-03 Plahey Kulwinder S Peritoneal dialysis therapy validation
US8226293B2 (en) 2007-02-22 2012-07-24 Medical Solutions, Inc. Method and apparatus for measurement and control of temperature for infused liquids
US20140199193A1 (en) 2007-02-27 2014-07-17 Deka Products Limited Partnership Blood treatment systems and methods
US8562834B2 (en) 2007-02-27 2013-10-22 Deka Products Limited Partnership Modular assembly for a portable hemodialysis system
JP5654466B2 (en) 2008-08-27 2015-01-14 デカ・プロダクツ・リミテッド・パートナーシップ Method of operating a dialysis system
US8409441B2 (en) 2007-02-27 2013-04-02 Deka Products Limited Partnership Blood treatment systems and methods
US8357298B2 (en) 2007-02-27 2013-01-22 Deka Products Limited Partnership Hemodialysis systems and methods
EP2197513B1 (en) 2007-10-12 2017-04-26 DEKA Products Limited Partnership Blood circuit assembly for a dialysis unit
US9028691B2 (en) 2007-02-27 2015-05-12 Deka Products Limited Partnership Blood circuit assembly for a hemodialysis system
KR101861192B1 (en) 2007-02-27 2018-05-28 데카 프로덕츠 리미티드 파트너쉽 Hemodialysis apparatus and methods
US7967022B2 (en) 2007-02-27 2011-06-28 Deka Products Limited Partnership Cassette system integrated apparatus
WO2008106452A1 (en) 2007-02-27 2008-09-04 Deka Products Limited Partnership Peritoneal dialysis sensor apparatus systems, devices and methods
US8042563B2 (en) 2007-02-27 2011-10-25 Deka Products Limited Partnership Cassette system integrated apparatus
US8425471B2 (en) 2007-02-27 2013-04-23 Deka Products Limited Partnership Reagent supply for a hemodialysis system
US20160058933A1 (en) 2007-02-27 2016-03-03 Deka Products Limited Partnership Control Systems and Methods for Blood or Fluid Handling Medical Devices
US8491184B2 (en) 2007-02-27 2013-07-23 Deka Products Limited Partnership Sensor apparatus systems, devices and methods
KR101385448B1 (en) 2007-02-27 2014-04-15 삼성디스플레이 주식회사 Circuit for driving source wire and display device having the same
US8393690B2 (en) 2007-02-27 2013-03-12 Deka Products Limited Partnership Enclosure for a portable hemodialysis system
US20080240929A1 (en) 2007-03-30 2008-10-02 Deka Products Limited Partnership Pumping Cassette
WO2008129084A1 (en) 2007-04-23 2008-10-30 Fundación Para La Investigación Biomédica Del Hospital Gregorio Marañon Haemodialfiltration method and apparatus
US7835074B2 (en) * 2007-06-05 2010-11-16 Sterling Lc Mini-scope for multi-directional imaging
EP2002855B1 (en) 2007-06-14 2012-07-11 RenApta B.V. Artificial kidney
US7955295B2 (en) 2007-07-05 2011-06-07 Baxter International Inc. Fluid delivery system with autoconnect features
US7957927B2 (en) 2007-07-05 2011-06-07 Baxter International Inc. Temperature compensation for pneumatic pumping system
US8512553B2 (en) 2007-07-05 2013-08-20 Baxter International Inc. Extracorporeal dialysis ready peritoneal dialysis machine
US7790103B2 (en) 2007-07-05 2010-09-07 Baxter International Inc. Extended use dialysis system
US8287724B2 (en) 2007-07-05 2012-10-16 Baxter International Inc. Dialysis fluid measurement systems using conductive contacts
US7905855B2 (en) * 2007-07-05 2011-03-15 Baxter International Inc. Dialysis system having non-invasive temperature sensing
US8057423B2 (en) 2007-07-05 2011-11-15 Baxter International Inc. Dialysis system having disposable cassette
US8764702B2 (en) 2007-07-05 2014-07-01 Baxter International Inc. Dialysis system having dual patient line connection and prime
US7901376B2 (en) 2007-07-05 2011-03-08 Baxter International Inc. Dialysis cassette having multiple outlet valve
US7736328B2 (en) 2007-07-05 2010-06-15 Baxter International Inc. Dialysis system having supply container autoconnection
US8105266B2 (en) 2007-07-05 2012-01-31 Baxter International Inc. Mobile dialysis system having supply container detection
US7909795B2 (en) 2007-07-05 2011-03-22 Baxter International Inc. Dialysis system having disposable cassette and interface therefore
US8496609B2 (en) 2007-07-05 2013-07-30 Baxter International Inc. Fluid delivery system with spiked cassette
US8330579B2 (en) 2007-07-05 2012-12-11 Baxter International Inc. Radio-frequency auto-identification system for dialysis systems
US8715235B2 (en) 2007-07-05 2014-05-06 Baxter International Inc. Dialysis system having disposable cassette and heated cassette interface
US20090007642A1 (en) * 2007-07-05 2009-01-08 Baxter International Inc. Dialysis fluid measurement method and apparatus using conductive contacts
US8597505B2 (en) 2007-09-13 2013-12-03 Fresenius Medical Care Holdings, Inc. Portable dialysis machine
US20090076434A1 (en) 2007-09-13 2009-03-19 Mischelevich David J Method and System for Achieving Volumetric Accuracy in Hemodialysis Systems
CN102784422B (en) * 2007-09-19 2015-05-06 弗雷塞尼斯医疗保健控股公司 Dialysis systems and related components
US7892197B2 (en) 2007-09-19 2011-02-22 Fresenius Medical Care Holdings, Inc. Automatic prime of an extracorporeal blood circuit
US8444587B2 (en) 2007-10-01 2013-05-21 Baxter International Inc. Fluid and air handling in blood and dialysis circuits
US7938792B2 (en) 2007-10-01 2011-05-10 Baxter International Inc. Adaptive algorithm for access disconnect detection
US8728020B2 (en) 2007-10-04 2014-05-20 Gambro Lundia Ab Infusion apparatus
EP2217301A2 (en) * 2007-10-12 2010-08-18 DEKA Products Limited Partnership Systems, devices and methods for cardiopulmonary treatment and procedures
US7887495B2 (en) 2007-10-18 2011-02-15 Boyd Lawrence M Protective and cosmetic covering for external fixators
US8858787B2 (en) 2007-10-22 2014-10-14 Baxter International Inc. Dialysis system having non-invasive fluid velocity sensing
US8114276B2 (en) 2007-10-24 2012-02-14 Baxter International Inc. Personal hemodialysis system
US20090113335A1 (en) 2007-10-30 2009-04-30 Baxter International Inc. Dialysis system user interface
US7905853B2 (en) 2007-10-30 2011-03-15 Baxter International Inc. Dialysis system having integrated pneumatic manifold
US8038640B2 (en) 2007-11-26 2011-10-18 Purity Solutions Llc Diaphragm pump and related systems and methods
JP2009125421A (en) 2007-11-27 2009-06-11 Jms Co Ltd Hemodialysis unit
US8137553B2 (en) 2007-11-29 2012-03-20 Fresenius Medical Care Holdings, Inc. Priming system and method for dialysis systems
US20160082173A1 (en) 2009-01-23 2016-03-24 Deka Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
JP5416137B2 (en) 2008-01-23 2014-02-12 デカ・プロダクツ・リミテッド・パートナーシップ Automated peritoneal dialysis system
EP2096566B1 (en) 2008-02-29 2018-04-04 Fresenius Medical Care Holdings, Inc. Instructional media system for dialysis machine
US20090294359A1 (en) 2008-06-03 2009-12-03 Baxter International Inc. Priming system and method using pumping and gravity
US8771508B2 (en) 2008-08-27 2014-07-08 Deka Products Limited Partnership Dialyzer cartridge mounting arrangement for a hemodialysis system
US8863772B2 (en) 2008-08-27 2014-10-21 Deka Products Limited Partnership Occluder for a medical infusion system
US20100056975A1 (en) 2008-08-27 2010-03-04 Deka Products Limited Partnership Blood line connector for a medical infusion device
US8142649B2 (en) 2009-01-29 2012-03-27 Baxter International Inc. Method for optimizing tidal therapies employing ultrafiltrate trending
US8182673B2 (en) 2009-01-29 2012-05-22 Baxter International Inc. Drain and fill logic for automated peritoneal dialysis
WO2011053810A3 (en) 2009-10-30 2011-06-30 Deka Products Limited Partnership Apparatus and method for detecting disconnection of an intravascular access device
DE102009060330A1 (en) 2009-12-23 2011-06-30 Fresenius Medical Care Deutschland GmbH, 61352 Dialysis machine, particularly peritoneal
EP2591385B1 (en) 2010-07-07 2017-10-11 DEKA Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
US9724458B2 (en) 2011-05-24 2017-08-08 Deka Products Limited Partnership Hemodialysis system
US9999717B2 (en) 2011-05-24 2018-06-19 Deka Products Limited Partnership Systems and methods for detecting vascular access disconnection
EP3263150A1 (en) 2011-05-24 2018-01-03 DEKA Products Limited Partnership Blood treatment systems and methods
US8906240B2 (en) 2011-08-29 2014-12-09 Fresenius Medical Care Holdings, Inc. Early detection of low bicarbonate level
EP3219342A1 (en) 2011-11-04 2017-09-20 DEKA Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
US9364655B2 (en) 2012-05-24 2016-06-14 Deka Products Limited Partnership Flexible tubing occlusion assembly
US20150196699A9 (en) 2013-03-15 2015-07-16 Deka Products Limited Partnership Blood treatment systems and methods

Patent Citations (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2816514A (en) * 1954-09-17 1957-12-17 Designers For Industry Inc Vibratory pump
US3539081A (en) * 1968-07-05 1970-11-10 Jet Spray Cooler Inc Valve for beverage dispensers
US3759483A (en) * 1971-05-14 1973-09-18 T Baxter Fluid actuated control valve
US3827561A (en) * 1972-09-20 1974-08-06 Milton Roy Co Deaerator for dialysis system
US3882861A (en) * 1973-09-24 1975-05-13 Vital Assists Auxiliary control for a blood pump
US4155852A (en) * 1976-11-19 1979-05-22 Halbert Fischel Low leakage current medical instrument
US4096859A (en) * 1977-04-04 1978-06-27 Agarwal Mahesh C Apparatus for peritoneal dialysis
US4266814A (en) * 1979-03-23 1981-05-12 Vfp Corporation Plastic tube adapter
US4282099A (en) * 1979-12-10 1981-08-04 Jones John L Integral partitioned hemodialysis unit
US4490254A (en) * 1980-02-25 1984-12-25 Bentley Laboratories, Inc. Blood filter
US4439188A (en) * 1980-09-15 1984-03-27 Baxter Travenol Laboratories, Inc. Tube connector
US5033513A (en) * 1980-10-29 1991-07-23 Proprietary Technology, Inc. Swivelable quick connector assembly
US5782508A (en) * 1980-10-29 1998-07-21 Proprietary Technologies, Inc. Swivelable quick connector assembly
US4398908A (en) * 1980-11-28 1983-08-16 Siposs George G Insulin delivery system
US4322054A (en) * 1980-12-29 1982-03-30 Red Valve Company, Inc. Pinch valve
US4623450A (en) * 1981-06-16 1986-11-18 Hospal Industrie Artificial kidney
US4501405A (en) * 1983-06-21 1985-02-26 Bunnell Life Systems, Inc. Frictionless valve/pump
US4585442A (en) * 1984-07-26 1986-04-29 Ivy Medical, Inc. Miniature intravenous infusion rate controller
US4695385A (en) * 1985-04-29 1987-09-22 Colorado Medical, Inc. Dialyzer reuse system
US4828543A (en) * 1986-04-03 1989-05-09 Weiss Paul I Extracorporeal circulation apparatus
US4833329A (en) * 1987-11-20 1989-05-23 Mallinckrodt, Inc. System for generating and containerizing radioisotopes
US5061241A (en) * 1989-01-19 1991-10-29 Stephens Jr Harry W Rapid infusion device
US5110477A (en) * 1990-02-13 1992-05-05 Howard David B Dialyzer clearance check system
US5351686A (en) * 1990-10-06 1994-10-04 In-Line Diagnostics Corporation Disposable extracorporeal conduit for blood constituent monitoring
US5105981A (en) * 1990-11-19 1992-04-21 Thomas Gehman Selectively shakeable freestanding particulate matter reservoir
US5879316A (en) * 1990-12-28 1999-03-09 University Of Pittsburgh Of The Commonwealth System Of Higher Education Portable and modular cardiopulmonary bypass apparatus and associated aortic balloon catheter and associated method
US5300044A (en) * 1991-09-26 1994-04-05 Baxter International Inc. Intravenous tube safety apparatus
US5411472A (en) * 1992-07-30 1995-05-02 Galen Medical, Inc. Low trauma blood recovery system
US5527507A (en) * 1992-10-01 1996-06-18 American Sterilizer Company Accumulator based liquid metering system and method
US5441636A (en) * 1993-02-12 1995-08-15 Cobe Laboratories, Inc. Integrated blood treatment fluid module
USD350850S (en) * 1993-04-20 1994-09-27 Paolo Maniglio Jewelry case
US5385540A (en) * 1993-05-26 1995-01-31 Quest Medical, Inc. Cardioplegia delivery system
US5441343A (en) * 1993-09-27 1995-08-15 Topometrix Corporation Thermal sensing scanning probe microscope and method for measurement of thermal parameters of a specimen
US5632894A (en) * 1994-06-24 1997-05-27 Gish Biomedical, Inc. Arterial blood filter with upwardly inclining delivery inlet conduit
US5541344A (en) * 1994-06-30 1996-07-30 G. D. Searle & Co. Intermediates useful in a process for the preparation of azanoradamantane benzamides
US5591344A (en) * 1995-02-13 1997-01-07 Aksys, Ltd. Hot water disinfection of dialysis machines, including the extracorporeal circuit thereof
US6146523A (en) * 1995-02-13 2000-11-14 Aksys, Ltd. User interface and method for control of medical instruments, such as dialysis machines
US5651765A (en) * 1995-04-27 1997-07-29 Avecor Cardiovascular Inc. Blood filter with concentric pleats and method of use
US5931648A (en) * 1995-05-30 1999-08-03 Servicio Regional De Salud, De La Consejeria De Salud De La Comunidad De Madrid Vacuum actuated tubular blood pumping device with active values and application of the same
US6139819A (en) * 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US5692729A (en) * 1996-02-16 1997-12-02 Vision-Sciences, Inc. Pressure equalized flow control apparatus and method for endoscope channels
US6491656B1 (en) * 1996-11-22 2002-12-10 Therakos, Inc. Integrated cassette for controlling fluid having an integral filter
US7214210B2 (en) * 1997-08-22 2007-05-08 Deka Products Limited Partnership Cassette and method for drug preparation and delivery
US6176904B1 (en) * 1999-07-02 2001-01-23 Brij M. Gupta Blood filter
US7559524B2 (en) * 1999-07-20 2009-07-14 Deka Products Limited Partnership Tube occluder for occluding collapsible tubes
US6663359B2 (en) * 1999-07-20 2003-12-16 Deka Products Limited Partnership Pump chamber having at least one spacer for inhibiting the pumping of a gas
US20100296953A1 (en) * 1999-07-20 2010-11-25 Deka Products Limited Partnership Pump chamber configured to contain a residual fluid volume for inhibiting the pumping of a gas
US20090202367A1 (en) * 1999-07-20 2009-08-13 Deka Products Limited Partnership Tube occluder and method for occluding collapsible tubes
US6171261B1 (en) * 1999-08-06 2001-01-09 Becton Dickinson And Company Specimen collection device and method of delivering fluid specimens to test tubes
US6723062B1 (en) * 1999-09-03 2004-04-20 Baxter International Inc. Fluid pressure actuated blood pumping systems and methods with continuous inflow and pulsatile outflow conditions
US6543814B2 (en) * 2000-08-10 2003-04-08 John M. Bartholomew Quick connector
US20060002823A1 (en) * 2000-09-11 2006-01-05 Feldstein Mark J Fluidics system
US6595948B2 (en) * 2000-10-04 2003-07-22 Terumo Kabushiki Kaisha Peritoneal dialysis apparatus
US20040101026A1 (en) * 2001-05-23 2004-05-27 Metran Co., Ltd. Inspired air temperature measuring device in respiratory circuit
US20070166181A1 (en) * 2002-03-14 2007-07-19 Billy Nilson Ambulatory infusion membrane pump
US20030220599A1 (en) * 2002-05-24 2003-11-27 Lundtveit Loren M. One-piece tip protector and organizer
US7175606B2 (en) * 2002-05-24 2007-02-13 Baxter International Inc. Disposable medical fluid unit having rigid frame
US7815595B2 (en) * 2002-05-24 2010-10-19 Baxter International Inc. Automated dialysis pumping system
US7500962B2 (en) * 2002-05-24 2009-03-10 Baxter International Inc. Medical fluid machine with air purging pump
US20030220607A1 (en) * 2002-05-24 2003-11-27 Don Busby Peritoneal dialysis apparatus
US7867214B2 (en) * 2002-07-19 2011-01-11 Baxter International Inc. Systems and methods for performing peritoneal dialysis
US20050069427A1 (en) * 2002-09-02 2005-03-31 Christiane Roemuss Housing for a fluid flow engine
US7727176B2 (en) * 2003-02-07 2010-06-01 Gambro Lundia Ab Machine for extracorporeal blood treatment coupled to a support element
US20050126988A1 (en) * 2003-02-19 2005-06-16 Thacker Kris O. Water clarification system with weir
US7465285B2 (en) * 2003-09-03 2008-12-16 Therakos, Inc. Control system for driving fluids through an extracorporeal blood circuit
US20050095141A1 (en) * 2003-10-30 2005-05-05 Deka Products Limited Partnership System and method for pumping fluid using a pump cassette
US7632080B2 (en) * 2003-10-30 2009-12-15 Deka Products Limited Partnership Bezel assembly for pneumatic control
US7488448B2 (en) * 2004-03-01 2009-02-10 Indian Wells Medical, Inc. Method and apparatus for removal of gas bubbles from blood
US7303540B2 (en) * 2004-04-26 2007-12-04 Chf Solutions, Inc. User interface for blood treatment device
US20050274658A1 (en) * 2004-06-09 2005-12-15 Rosenbaum Benjamin P Dialysis system
US7124996B2 (en) * 2004-07-16 2006-10-24 Cardinal Health 303, Inc. Automatic clamp apparatus for IV infusion sets used in pump devices
US7561968B2 (en) * 2004-10-13 2009-07-14 The Boeing Company Scale factor calibration and compensation for angular position resolver
US7776301B2 (en) * 2005-03-17 2010-08-17 Nox Ii, Ltd. Reducing mercury emissions from the burning of coal
US20110218600A1 (en) * 2006-04-14 2011-09-08 Deka Products Limited Partnership Heat exchange systems, devices and methods
US20090154524A1 (en) * 2006-04-28 2009-06-18 Agostino Girelli Integrated System for Hydro-Thermo-Sanitary Apparatuses
US7896022B2 (en) * 2006-06-07 2011-03-01 Eaton Corporation On-board refueling vapor recovery system with vent line check valve
US20090107335A1 (en) * 2007-02-27 2009-04-30 Deka Products Limited Partnership Air trap for a medical infusion device
US20090173682A1 (en) * 2007-11-29 2009-07-09 Thomas Patrick Robinson System and Method for Conducting Hemodialysis and Hemofiltration
US20110092875A1 (en) * 2008-04-30 2011-04-21 Gambro Lundia Ab Degassing device

Cited By (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8292594B2 (en) 2006-04-14 2012-10-23 Deka Products Limited Partnership Fluid pumping systems, devices and methods
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US8932469B2 (en) 2007-10-24 2015-01-13 Baxter International Inc. Personal hemodialysis system including priming sequence and methods of same
US9855377B2 (en) 2007-10-24 2018-01-02 Baxter International Inc. Dialysis system including heparin injection
US8329030B2 (en) 2007-10-24 2012-12-11 Baxter International Inc. Hemodialysis system with cassette and pinch clamp
US8834719B2 (en) 2007-10-24 2014-09-16 Baxter International Inc. Personal hemodialysis system
US9925320B2 (en) 2007-10-24 2018-03-27 Baxter International Inc. Renal therapy machine and system including a priming sequence
US8114276B2 (en) 2007-10-24 2012-02-14 Baxter International Inc. Personal hemodialysis system
US8323492B2 (en) 2007-10-24 2012-12-04 Baxter International Inc. Hemodialysis system having clamping mechanism for peristaltic pumping
US9022969B2 (en) 2008-01-23 2015-05-05 Deka Products Limited Partnership Fluid line autoconnect apparatus and methods for medical treatment system
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US20110071465A1 (en) * 2008-01-23 2011-03-24 Deka Research & Development Fluid volume determination for medical treatment system
US8840581B2 (en) 2008-01-23 2014-09-23 Deka Products Limited Partnership Disposable components for fluid line autoconnect systems and methods
US9358332B2 (en) 2008-01-23 2016-06-07 Deka Products Limited Partnership Pump cassette and methods for use in medical treatment system using a plurality of fluid lines
US8197439B2 (en) 2008-01-23 2012-06-12 Deka Products Limited Partnership Fluid volume determination for medical treatment system
US9839775B2 (en) 2008-01-23 2017-12-12 Deka Products Limited Partnership Disposable components for fluid line autoconnect systems and methods
US9028440B2 (en) 2008-01-23 2015-05-12 Deka Products Limited Partnership Fluid flow occluder and methods of use for medical treatment systems
US9248225B2 (en) 2008-01-23 2016-02-02 Deka Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
US9839776B2 (en) 2008-01-23 2017-12-12 Deka Products Limited Partnership Fluid flow occluder and methods of use for medical treatment systems
US9078971B2 (en) 2008-01-23 2015-07-14 Deka Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
US8771508B2 (en) 2008-08-27 2014-07-08 Deka Products Limited Partnership Dialyzer cartridge mounting arrangement for a hemodialysis system
US8863772B2 (en) 2008-08-27 2014-10-21 Deka Products Limited Partnership Occluder for a medical infusion system
US8708950B2 (en) 2010-07-07 2014-04-29 Deka Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
US9366781B2 (en) 2010-07-07 2016-06-14 Deka Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
US9907897B2 (en) 2011-03-23 2018-03-06 Nxstage Medical, Inc. Peritoneal dialysis systems, devices, and methods
US9717834B2 (en) 2011-05-24 2017-08-01 Deka Products Limited Partnership Blood treatment systems and methods
US9999717B2 (en) 2011-05-24 2018-06-19 Deka Products Limited Partnership Systems and methods for detecting vascular access disconnection
US9724458B2 (en) 2011-05-24 2017-08-08 Deka Products Limited Partnership Hemodialysis system
US9981079B2 (en) 2011-11-04 2018-05-29 Deka Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
US9861732B2 (en) 2011-11-04 2018-01-09 Deka Products Limited Partnership Medical treatment system and methods using a plurality of fluid lines
US9861733B2 (en) 2012-03-23 2018-01-09 Nxstage Medical Inc. Peritoneal dialysis systems, devices, and methods
US9364655B2 (en) 2012-05-24 2016-06-14 Deka Products Limited Partnership Flexible tubing occlusion assembly
US9700711B2 (en) 2012-05-24 2017-07-11 Deka Products Limited Partnership Flexible tubing occlusion assembly

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