JP2006204343A - Auxiliary artificial heart - Google Patents

Auxiliary artificial heart Download PDF

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JP2006204343A
JP2006204343A JP2005016652A JP2005016652A JP2006204343A JP 2006204343 A JP2006204343 A JP 2006204343A JP 2005016652 A JP2005016652 A JP 2005016652A JP 2005016652 A JP2005016652 A JP 2005016652A JP 2006204343 A JP2006204343 A JP 2006204343A
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diaphragm
chamber
conduit
blood
body
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Tatsuya Kurosaki
Taijiro Sueda
泰二郎 末田
達也 黒崎
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Hiroshima Univ
国立大学法人広島大学
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Abstract

<P>PROBLEM TO BE SOLVED: To provide an auxiliary artificial heart dispensing with a special processing or means and having superior antithrombogenicity in a simple structure. <P>SOLUTION: This auxiliary artificial heart is provided with a spherical segment body 11, a diaphragm 20 partitioning the interior of the body into a blood chamber and a fluid chamber, an inflow duct 31 and an outflow duct 32 opened to the blood chamber, and a driving source feeding the fluid for driving the diaphragm to the fluid chamber through a driving fluid deed pipe 38; and is formed by having a semispherical projection part at the top of the diaphragm. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

本発明はダイヤフラムを用いた補助人工心臓に係り、特に血流のよどみ部の発生の防止を図り円滑な流れの血流を得ることができる抗血栓性に優れた補助人工心臓に関する。 The present invention relates to heart assist with diaphragm, in particular to heart assist with excellent antithrombotic properties that can be obtained blood flow smooth flow aims to prevent stagnation of the occurrence of blood flow.

ダイヤフラムを用いた補助人工心臓は、簡単な構造で体積効率が優れており、血液に与える損傷も少ないので多くの臨床応用の検討がなされている。 Heart assist with diaphragm, it has excellent volumetric efficiency with a simple structure, consideration of a number of clinical applications because damage is small to provide blood have been made. そしてこの補助人工心臓の実用化において重要な問題の1つになっているのが血栓の発生である。 And it has become one of the important problems in the practical application of this auxiliary artificial heart is the occurrence of thrombosis.

血栓の発生を防止する手段として、例えば、特許文献1に、補助人工心臓の血液接触面が、オゾン処理により生成された基材表面の酸化物中に含まれる官能基と、ヘパリンのアミノ基とが、直接、または少なくとも一種のカップリング剤を介して共有結合した抗血栓性表面となっている補助人工心臓が提案されている。 As means for preventing the occurrence of thrombosis, for example, in Patent Document 1, the blood contact surface of the auxiliary artificial heart, a functional group contained in the oxide of the generated surface of the substrate by ozone treatment, the amino group of heparin but directly, or at least one auxiliary artificial heart via the coupling agent has a covalently bound anti-thrombogenic surfaces have been proposed.

特許文献2には、血栓の発生は避けられないものとして、生じた血栓の除去・清掃が容易、かつ、迅速にできる分解型の補助人工心臓が提案されている。 Patent Document 2, as the occurrence of thrombotic inevitable, removal and cleaning of the resulting thrombus easily and decomposition type auxiliary artificial heart can be quickly have been proposed.

特開平06-105902号公報 JP 06-105902 discloses 特開2002-102333号公報 JP 2002-102333 JP

しかし、特許文献1に提案された補助人工心臓においては、複雑な形状を有する逆流防止弁部分を含めて補助人工心臓の血液が接触するすべての内表面に抗血栓性層を形成するのは容易でなく、均質な抗血栓性層を確保するのは困難であるという問題がある。 However, in the proposed ventricular assist in Patent Document 1, it is easy to form the anti-thrombogenic layer on all internal surfaces of blood contacting the including check valve portion auxiliary artificial heart having a complex shape not, is to ensure homogeneity antithrombotic layer is difficult. また、特許文献2に提案された補助人工心臓においては、補助人工心臓の分解、清掃及び再組み立てに手間を要するという問題がある。 In the proposed ventricular assist in Patent Document 2, decomposition of ventricular assist, there is a problem of requiring labor for cleaning and reassembly.

本発明は、かかる従来の問題点に鑑み特別な処理又は手段を要せず、簡潔な構造で抗血栓性に優れる補助人工心臓を提供することを目的とする。 The present invention is, without the need for special processing or means in view of such conventional problems, and an object thereof is to provide a ventricular assist excellent in antithrombotic in a compact structure.

本発明に係る補助人工心臓は、球欠状の本体と、該本体の内部を血液室と流体室に区画するダイヤフラムと、前記血液室に開口する流入導管及び流出導管と、前記流体室に駆動流体供給管を通じて前記ダイヤフラム駆動用の流体を供給する駆動源とを有する補助人工心臓であって、前記ダイヤフラムの頂部に半球状凸部を設けてなる。 Auxiliary artificial heart according to the present invention includes a domed body, and a diaphragm partitioning the interior of the body to the blood chamber and a fluid chamber, an inlet conduit and outlet conduit opening into said blood chamber, driving the fluid chamber a heart assist and a driving source for supplying the fluid for the diaphragm drive through the fluid supply tube, formed by providing a hemispherical protrusion on top of the diaphragm.

上記補助人工心臓において、流入導管と流出導管はダイヤフラムに設けられた半球状凸部を挟む平行線上に配設されているのが好ましく、また、流入導管と流出導管はダイヤフラムの本体取り付け部に対して平行又は傾斜して設けられているのが好ましい。 In the heart assist is preferably inflow conduit and the outflow conduit are arranged in parallel lines sandwiching a hemispherical projection provided on the diaphragm, also inflow conduit and the outflow conduit to the body mounting portion of the diaphragm the Te is provided in parallel or inclined preferred.

本発明に係る人工心臓は、簡潔な構造で特別な処理又は手段を要せず、血液室内の血流のよどみ部の発生を防止して円滑な血流を得ることができ、血栓の発生を防止することができる。 Artificial heart according to the present invention, without requiring any special treatment or means in a compact structure, to prevent the occurrence of stagnation of the blood chamber of the blood flow can be obtained a smooth blood flow, the generation of thrombi it is possible to prevent.

本発明の一実施例に係る補助人工心臓を図面に基づいて説明する。 The auxiliary artificial heart according to one embodiment of the present invention will be described with reference to the drawings. 図1は、本補助人工心臓の平面図であり、図2は図1のAA断面図である。 Figure 1 is a plan view of the present heart assist, FIG. 2 is a sectional view taken along the line AA of Figure 1. 本補助人工心臓は、図1及び図2に示すように、本体11と、その内部を血液室16と流体室18に区画するダイヤフラム20と、血液室16に開口する流入導管31及び流出導管32と、流体室18に開口する駆動流体供給管38を有し、さらに、駆動流体供給管38を通じてダイヤフラムの駆動流体を供給する駆動源(図示せず)とを有している。 This auxiliary artificial heart, as shown in FIGS. 1 and 2, a body 11, a diaphragm 20 that partitions the interior into the blood chamber 16 and the fluid chamber 18, inflow conduit 31 and outflow conduit 32 opens into the blood chamber 16 When, a driving fluid supply pipe 38 opening into the fluid chamber 18 further includes a diaphragm driving source for supplying the driving fluid and a (not shown) through a driving fluid supply pipe 38.

本体11は球欠状をしており、その上部の球欠部分に血液室16が形成される。 Body 11 is of a shape spherical segment, the blood chamber 16 is formed in a spherical segment portion of the upper. 本体11は、抗血栓性の高いポリウレタン樹脂製であるのが好ましい。 Body 11 is preferably made of antithrombotic highly polyurethane resin. アクリル樹脂にポリウレタン樹脂を塗布したものであってもよい。 It may be such that the polyurethane resin is applied to an acrylic resin. また、本体11は一体に形成され分解できないものであってもよく、また上部の球欠部分と下部部分が、例えばそれらの周縁部に設けたねじ結合により一体に結合され分解可能なものとすることもできる。 The main body 11 may be one that can not be decomposed integrally formed, also spherical segment and lower portions of the upper, and capable integrally coupled to degradation by, for example, a screw connection which is provided on their periphery it is also possible.

ダイヤフラム20は、図3に示すように中高の円板状をしており、本発明においてはその頂部に半球状凸部25が設けられている。 The diaphragm 20 has a convex circular plate shape as shown in FIG. 3, in the present invention are semi-spherical projection 25 is provided on its top. ダイヤフラム20の周縁部にはフランジ23が形成され、図2に示すように本体11の取り付け部12に挟み込まれてダイヤフラム20が本体11に固定されるようになっている。 The periphery of the diaphragm 20 flange 23 is formed, the diaphragm 20 is sandwiched mounting portion 12 of the body 11 as shown in FIG. 2 is adapted to be secured to the body 11. 本体11はこのダイヤフラム20により上部の血液室16と、下部の流体室18とに区画されるようになっている。 Body 11 and the upper portion of the blood chamber 16 by the diaphragm 20, and is divided into a lower portion of the fluid chamber 18. なお、ダイヤフラム20の本体11への固定は、接着、融着又はねじによる締め付け固定等の方法を採用することができる。 The fixing of the main body 11 of the diaphragm 20 can be adopted bonding, a method of fixing such as fastening by welding or screws.

ダイヤフラム20には弾性を有し靱性の高いシリコンゴム、ポリウレタンゴムを使用することができる。 Silicone rubber to the diaphragm 20 of high toughness resilient, can be used polyurethane rubber. ダイヤフラム20の材質を本体11の材質と同一とし、ともにポリウレタン樹脂製にするのがよい。 The material of the diaphragm 20 is the same as the material of the body 11, together better to the polyurethane resin. これにより、相互の接着等が容易にでき、抗血栓性に優れる補助人工心臓を成形することができる。 Accordingly, adhesion or the like of each other can be easily can be formed an auxiliary artificial heart which is excellent in antithrombotic.

流入導管31は、図2に示すように本体11の血液室16に開口している。 Inlet conduit 31 is open to the blood chamber 16 of the body 11 as shown in FIG. その流入導管31の開口部13の近傍に流入逆止弁35が設けられており、血液は、流入導管31を通じて血液室16に流入することはできるが血液室16から流出することはできない。 As has flowed check valve 35 in the vicinity of the opening 13 of the inflow conduit 31 is provided, the blood flow into the blood chamber 16 may not be able to flow out from the blood chamber 16 through the inlet conduit 31. また、流出導管32が本体11の血液室16に開口しており、流出導管32の開口部14の近傍に流出逆止弁36が設けられている。 Further, the outflow conduit 32 is opened to the blood chamber 16 of the body 11, the outflow check valve 36 is provided in the vicinity of the opening 14 of the outlet conduit 32. これにより、血液は流出導管32を通じて血液室16から流出することはできるが、血液室16に流入することはできない。 Thus, blood may be flowing out from the blood chamber 16 through the outflow conduit 32 can not flow into the blood chamber 16.

本例では、流入導管31と流出導管32は平行に配設され、かつ、ダイヤフラム20の半球状凸部25を挟む平行線上に配設されている。 In this example, the inflow conduit 31 and outflow conduit 32 are disposed parallel to, and are arranged in parallel lines sandwiching the hemispherical projection 25 of the diaphragm 20. これにより、流入導管31から血液室16に流入した血液は、本体11の周壁部に沿って半球状凸部25を周回し、その後流出導管32から容易に流出するので、滑らかな血流が形成される。 Thus, blood flows into the blood chamber 16 from inlet conduit 31, because along the peripheral wall of the main body 11 around the hemispherical protrusions 25, easily flows out from further outflow conduit 32, a smooth blood flow forms It is.

駆動流体供給管38は流体室18に開口しており、この駆動流体供給管38を通じて駆動源からダイヤフラム20を駆動する流体が供給される。 Driving fluid supply pipe 38 is open to the fluid chamber 18, the fluid that drives the diaphragm 20 from the driving source through the driving fluid supply pipe 38 is supplied. 駆動流体は気体又は液体を使用することができる。 Driving fluid may be a gas or a liquid. 駆動源は、例えば空気の供給と吸引を繰り返して行うことができる特開2004-275302号公報に記載の補助人工心臓用簡易駆動装置を好適に使用することができる。 Driving source can be suitably used a simple drive device for an auxiliary artificial heart described in JP-A-2004-275302 can be carried out for example by repeating suction and supply of air.

このような補助人工心臓における血流の状態を図4に示す。 Shows the state of blood flow in such a ventricular assist in FIG. それぞれ、(a)はポンプ拡張初期、(b)はポンプ拡張中期における血流の方向を示し、長い矢印は早い流速を、短い矢印は遅い流速を示す。 Respectively show (a) shows the pump extension early, (b) indicate the direction of blood flow in the pump extension metaphase, long arrows for faster flow rates, shorter arrows slow flow rate. (c)はポンプ拡張終期における血流の流線を示す。 (C) shows the streamlines of blood flow in the pump end diastole. 流線が密であるほど強い一定の方向の流れがあることを示す。 Streamlines indicates that there is a strong constant direction of flow as it is dense. (d)はポンプ収縮の初期における血流の方向を示す。 (D) of indicating the direction of blood flow in the initial pump contraction.

本発明の比較例として、ダイヤフラムに半球状凸部25がない点のみが異なる補助人工心臓の場合の血流の状態を図5に示す。 As a comparative example of the present invention, showing the state of blood flow in the case only in absence of hemispherical projections 25 on the diaphragm is different heart assist in FIG. 図5(a)〜(d)は図4の場合に対応している。 Figure 5 (a) ~ (d) corresponds to the case of FIG. 図4及び5を比較すると、本発明の人工心臓は、血液室16全体に一定の強い流れの方向を有し、血流のよどみ部がないことが分かる。 Comparing Figures 4 and 5, the artificial heart of the present invention, the whole blood chamber 16 has a direction of constant strong flow, it can be seen that there is no stagnation of blood flow.

ポンプ収縮初期の血流方向を示す図4(d)と図5(d)を比較すると、本発明例では、血液室16の中心部から本体11の周壁に沿い流出導管32の開口部14に向かって旋回する渦巻き状の血流が見られる。 When FIG. 4 showing the blood flow direction of the pump shrinkage initial (d) and comparing the FIG. 5 (d), the present in invention example, from the center of the blood chamber 16 to the opening 14 of the along outflow conduit 32 in the peripheral wall of the main body 11 spiral blood flow headed pivot is observed. 一方これに対し、比較例では血液室16の中心部から流出導管32の開口部14と反対側の本体11の周壁に衝突するような血流が見られる。 Meanwhile contrast, blood flow, such as to impinge on the peripheral wall of the opening 14 and the opposite side of the body 11 of the outflow conduit 32 from the center of the blood chamber 16 can be seen in the comparative example.

また、図4と図5を比較すると、本発明例においては、血流はダイヤフラムの半球状凸部25を中心として周回するように流れていることが分かる。 In comparison to FIG. 4 and FIG. 5, in the present invention embodiment, it is understood that blood is flowing so as to surround around the hemispherical projection 25 of the diaphragm. これに対し、比較例においては、渦巻き状の血流を生じにくく、また、渦巻き状の血流が生じたとしても渦巻きの中心部が明確でなく、流れの弱い渦巻きになりやすいことが分かる。 In contrast, in the comparative example, hardly occurs a spiral blood flow, also not clear that the center of the spiral as the spiral blood flow occurs, it can be seen that tends to flow weak swirl.

このように本発明に係る補助人工心臓内においては、ダイヤフラムの半球状凸部25を中心として血液室16の全体にわたった旋回する血流を生じやすい。 In the auxiliary in artificial heart according to the present invention, prone to blood flow to pivot across the whole of the blood chamber 16 around the hemispherical projection 25 of the diaphragm. また、流入導管31から流入した血液が本体11の周壁部に沿って半球状凸部25を周回し、その後流出導管32から容易に流出されるような滑らかな血流が形成されやすい。 Moreover, blood flowing in from the inflow conduit 31 is orbiting the hemispherical protrusions 25 along the peripheral wall of the main body 11, tends to be smooth blood flow as easily flow out from further outflow conduit 32 is formed. このため、本補助人工心臓においては、血流のよどみ部を生じにくく血栓が生じにくいことが分かる。 Therefore, in the present heart assist, it can be seen that hardly occurs hardly thrombi cause stagnation of the blood flow.

なお、図4及び5は、可視化剤とレーザーライトシートを組み合わせたレーザー光の強度変化から流れを可視的に解析するPIV法を用いて求めた。 Incidentally, FIG. 4 and 5 were determined using the PIV method to visually analyze the flow from the intensity change of the laser beam that combines visualization agent and laser light sheet. レーザーライトシートは、35mWのHe-Ne及び10mWのHe-Neレーザーライトシートを使用した。 Laser light sheet, was used He-Ne laser light sheet of He-Ne and 10mW of 35 mW. トレーサは、200〜400μmのポリスチレンビーズを使用した。 The tracer was used polystyrene beads of 200~400μm. 撮影は、100fpsのNTSC型高感度CCDカメラを使用した。 Imaging, using a NTSC type highly sensitive CCD camera 100 fps.

上述のように本補助人工心臓は血流によどみ部が生じにくく、血液室全体にわたる円滑な流れの血流を得ることができ、血栓が発生しにくい。 The present heart assist as described above hardly occurs stagnation portion into the bloodstream, it is possible to obtain the blood flow smooth flow throughout the blood chamber, thrombosis is less likely to occur. このような効果を十分に得るには補助人工心臓ごとに上述のPIV法を用いた解析により、ダイヤフラム20の半球状凸部25の形状、最大径や高さ等を最適なものにする必要がある。 Such effect analysis using the PIV method described above for each ventricular assist to obtain sufficiently the shape of the hemispherical projection 25 of the diaphragm 20, it is necessary to optimize the maximum diameter and height, etc. is there.

本発明は上記の実施例に限定されない。 The present invention is not limited to the embodiments described above. 例えば、図6に示すように、さらに、流入導管31と流出導管32がダイヤフラムの本体取り付け部12に対して傾斜して取り付けられるようにすることができる。 For example, as shown in FIG. 6 can further inflow conduit 31 and outflow conduit 32 are to be mounted inclined relative to the main body mounting portion 12 of the diaphragm. この場合は、より一層血流によどみ部が発生しにくく、血液室16の全体にわたる円滑な流れの血流を得ることができる。 In this case, less likely even stagnation portion is generated in the bloodstream, it is possible to obtain the blood flow throughout smooth flow of the blood chamber 16. 流入導管31と流出導管32のダイヤフラムの本体取り付け部12(本体11の底面)に対する角度θは45°以下がよく、好ましくは30°〜45°とするのがよい。 Diaphragm body mounting portion 12 of the inflow conduit 31 and outflow conduit 32 are angle θ with respect to (the bottom surface of the main body 11) good 45 ° or less, and it is preferably a 30 ° to 45 °.

本発明に係る補助人工心臓の正面図である。 It is a front view of an auxiliary artificial heart according to the present invention. 図1のAA断面図である。 It is a sectional view taken along the line AA of Figure 1. ダイヤフラムの斜視図である。 It is a perspective view of a diaphragm. 上記補助人工心臓の血流の状態を表す模式図である。 Is a schematic view illustrating a state of the blood flow in the heart assist. 比較例の補助人工心臓の血流の状態を表す模式図である。 Is a schematic view illustrating the state of blood flow ventricular assist the comparative example. 流入導管と流出導管とをダイヤフラムの本体取り付け部に傾斜して取り付けた実施例を示す斜視図である。 An inlet conduit and outlet conduit is a perspective view showing an embodiment in which the mounting is inclined to the main body mounting portion of the diaphragm.

符号の説明 DESCRIPTION OF SYMBOLS

11 本体 11 body
12 本体取り付け部 12 body attachment portion
13、14 開口部 13 and 14 opening
16 血液室 16 blood chamber
18 流体室 18 fluid chamber
20 ダイヤフラム 20 diaphragm
23 フランジ 23 flange
25 半球状凸部 25 semi-spherical convex portion
31 流入導管 31 inflow conduit
32 流出導管 32 outflow conduit
35 流入逆止弁 35 inflow check valve
36 流出逆止弁 36 outflow check valve
38 駆動流体供給管 38 driving fluid supply pipe

Claims (3)

  1. 球欠状の本体と、該本体の内部を血液室と流体室に区画するダイヤフラムと、前記血液室に開口する流入導管及び流出導管と、前記流体室に駆動流体供給管を通じて前記ダイヤフラム駆動用の流体を供給する駆動源とを有する補助人工心臓であって、 A domed body, and a diaphragm partitioning the interior of the body to the blood chamber and a fluid chamber, an inlet conduit and outlet conduit opening into said blood chamber, for the diaphragm drive through the driving fluid supply pipe to the fluid chamber a heart assist and a driving source for supplying fluid,
    前記ダイヤフラムの頂部に半球状凸部を設けたことを特徴とする補助人工心臓。 Heart assist, characterized in that a hemispherical protrusion on top of the diaphragm.
  2. 請求項1に記載の補助人工心臓において、流入導管と流出導管はダイヤフラムに設けられた半球状凸部を挟む平行線上に配設されていることを特徴とする補助人工心臓。 In auxiliary artificial heart according to claim 1, inflow conduit and outflow conduit, characterized in that it is arranged in parallel lines sandwiching a hemispherical protrusion provided on the diaphragm ventricular assist.
  3. 請求項1又は2に記載の補助人工心臓において、流入導管と流出導管はダイヤフラムの本体取り付け部に対して平行又は傾斜して設けられていることを特徴とする補助人工心臓。 In auxiliary artificial heart according to claim 1 or 2, inflow conduit and outflow conduit, characterized in that it is provided in parallel or inclined with respect to the body mounting portion of the diaphragm ventricular assist.
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Cited By (17)

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JP2009533154A (en) * 2006-04-14 2009-09-17 デカ・プロダクツ・リミテッド・パートナーシップ Fluid pumping, heat exchanging, heat detection and conductivity detection systems, instruments and methods
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