CN108159285A - 一种增强免疫力的中药组合物及其制备方法 - Google Patents
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Abstract
本发明提供了一种中药组合物,原材料包括铁皮石斛、党参、白术、茯苓、桑椹,同时也提供了制备该中药组合物的方法,可分别制成硬糖、口服液、硬胶囊、糕点、酒剂等保健食品。本发明的优点在于,能够得到显著免疫力增强的效果,且营养均衡,实现各味药物之间的协同促进作用,组方的效果远远优于单味药物的叠加,实现了单味药物所不具备的显著增强机体免疫力的作用,且无毒副作用,长期食用,可以增加人体免疫力,预防疾病,提高生活质量工作效率。
Description
技术领域
本发明属于保健品技术领域,具体为一种增强免疫力的中药组合物及其制备方法。
背景技术
由于现代社会竞争的压力以及生活和工作环境等影响因素,免疫力低下人群越来越多。各种原因使免疫系统不能正常发挥保护作用,在此情况下,极易招致细菌、病毒、真菌等感染,因此免疫力低下最直接的表现就是容易生病。因经常患病,加重了机体的消耗,所以一般有体质虚弱、营养不良、精神萎靡、疲乏无力、食欲降低、睡眠障碍等表现,每次生病都要很长时间才能恢复,而且常常反复发作。经常服用治疗药物,如抗生素、化学合成药物还易对胃、肝、肾等身体器官造成不良影响,严重时可能引发疾病。
目前大多数人已经注意到这种现状,并通过不同方式来提升自身免疫力,如适当运动、戒烟戒酒、注意饮食、服用保健食品等。目前市场上销售的具有增强免疫力功能的保健食品品种繁多,有的成分比较单一,长期服用会使营养不均衡,有的成分多样化,但效果却并不显著。因此,一种安全有效的可以长期服用的具有增强免疫力功能的保健食品是现代人所需求的。
发明内容
为解决现有技术中增强免疫力的保健品配伍单一、调节作用欠缺的缺陷,本发明提供了一种增强免疫力的中药组合物及其制备方法,实现的目的为营养成分均衡,可长期安全食用,增强免疫力。
为了实现上述目的,本发明提供以下技术方案:本发明提供的一种增强免疫力的中药组合物,原材料包括铁皮石斛、党参、白术、茯苓、桑椹。
铁皮石斛20-60份、党参10-50份、白术10-50份、茯苓10-50份、桑椹10-50份,所述份数均是指该成分在原材料中的重量份数。
本发明选择的铁皮石斛味甘,微寒,归胃、肺、肾经,生津益胃、滋阴清热、润肺益肾、明目强腰。主热病伤津、口干烦渴、胃阴不足、胃痛干呕、肺燥干咳、虚热不退、阴伤目暗、腰膝软弱。
党参,味甘,性平,归脾、肺经,健脾补肺、益气生津。主脾胃虚弱、食少便溏、四肢乏力、肺虚喘咳、气短自汗、气微两亏诸证。
白术,味苦、甘、性温,归脾、胃经,健脾益气、燥湿利水、止汗、安胎。主脾气虚弱、神疲乏力、食少腹胀、大便溏薄、水饮内停、小便不利、水肿、痰饮眩晕、温痹酸痛、气虚自汗、胎动不安。
茯苓,味甘;淡,性平,归心;脾;肺;肾经,主渗湿利水;健脾和胃;宁心安神。主小便不利;水肿胀满;痰饮咳逆;呕吐;脾虚食少;泄泻;心悸不安;失眠健忘;遗精白浊。
桑椹,味甘、酸,性寒,归心、肝、肾经,补血滋阴,生津润燥。用于眩晕耳鸣,心悸失眠,须发早白,津伤口渴,内热消渴,血虚便秘。
本发明发现将上述原材料成分配伍,能够得到显著免疫力增强的中药组合物,且营养均衡,实现各味药物之间的协同促进作用,组方的效果远远优于单味药物的叠加,实现了单味药物所不具备的养胃补脾、润肺护肝、补肾荣心、益气生血的效果,显著增强的机体的免疫力,且无毒副作用,长期食用,可以增加人体免疫力,预防疾病,提高生活质量工作效率。
进一步的,本发明还提供了制备上述中药组合物的方法,例如:将铁皮石斛除外的五味药材,加8-12倍量的水,浸提2-3次,每次0.5-3小时,合并提取液,提取液100-400目过滤,在真空度-0.06~-0.08MPa,温度60-80℃条件下浓缩,精制,干燥至水分质量含量≤5%后备用,铁皮石斛粉碎成粉备用;将干膏粉与所述原材料粉混合均匀,制成软糖、硬糖、软胶囊、含片、咀嚼片、吞服片剂、泡腾片、颗粒剂、粉剂、茶剂、膏剂中任意一种剂型。
例如:将铁皮石斛、党参、白术、茯苓、桑椹原材料加水浸提,原材料与水的质量比为1:8-12,提取2-3次,每次0.5-3小时,合并提取液,过滤、浓缩,制成口服液、糖浆、饮料、酒剂中任意一种剂型。
例如:将铁皮石斛、党参、白术、茯苓、桑椹粉碎成60-120目以上细粉,混合均匀,制成硬胶囊、丸剂中任意一种剂型。
例如:将铁皮石斛、党参、白术、茯苓、桑椹原材料超微粉碎,混合均匀制成软糖、硬糖、软胶囊、含片、咀嚼片、吞服片剂、颗粒剂、粉剂、茶剂、膏剂、糕点中任意一种剂型。
例如:将原材料铁皮石斛、党参、白术、茯苓、桑椹粉碎成粗粉,用质量浓度为15-45%的酒浸泡或渗滤原材料,原材料与酒的体积比为1:10-20,浸泡或渗滤后过滤后配制成质量浓度为15-45%的酒剂。
本发明采用上述技术方案,包括以下有益效果:本发明的中药组合物,能够得到显著免疫力增强的效果,且营养均衡,实现各味药物之间的协同促进作用,组方的效果远远优于单味药物的叠加,实现了单味药物所不具备的显著增强机体免疫力的效果,且无毒副作用,长期食用,可以增加人体免疫力,预防疾病,提高生活质量工作效率。
具体实施方式
下面通过具体的实施例对本发明做进一步的详细描述。本发明没有特殊说明,所述的方法步骤均采用的是现有技术,在没有对工作条件参数做出特殊说明时,采用的均是常温常压条件。
实施例一:本发明提供的一种增强免疫力的中药组合物,原材料包括铁皮石斛、党参、白术、茯苓、桑椹,铁皮石斛20份、党参10份、白术10份、茯苓10份、桑椹10份,所述份数均是指该成分在原材料中的重量份数。
可采用任意一种方法将本发明这种中药组合物加工成可食用的保健品,本发明的这种中药组合物,筛选出来的上述原材料配伍之后增强免疫力的功效最为显著。
按实施例一组方制成片剂,以某牌蛋白粉做对照,分别经口给予小鼠低、中、高三个计量30天,判断两种产品在细胞免疫功能、体液免疫功能、单核-巨噬细胞功能、NK细胞活性四个方面的结果,实验结果如下:
根据试验结果显示:实施例一组方制成片剂在细胞免疫功能、体液免疫功能、单核-巨噬细胞功能、NK细胞活性四个方面的增强免疫力效果由于对照组。
实施例二:本发明提供的一种增强免疫力的中药组合物,原材料包括铁皮石斛、党参、白术、茯苓、桑椹,铁皮石斛60份、党参50份、白术50份、茯苓50份、桑椹50份,所述份数均是指该成分在原材料中的重量份数。
将铁皮石斛除外的五味药材,加8倍量的水,浸提2次,每次0.5小时,合并提取液,提取液100-400目过滤,在真空度-0.06MPa,温度60℃条件下浓缩,精制,干燥至水分质量含量≤5%后备用,铁皮石斛粉碎成粉备用;将干膏粉与所述原材料粉混合均匀,制成软糖、硬糖、软胶囊、含片、咀嚼片、吞服片剂、泡腾片、颗粒剂、粉剂、茶剂、膏剂中任意一种剂型。
以下试验用于说明,本发明在选择提取次数、提取时间、以及加水量时筛选的过程,用以说明本发明最终选择的提取次数、提取时间、以及加水量为最优选的,以下列举在提取2次和提取时间为1小时的条件下考察加水量对产品有效成分的影响,以提取液中的多糖提取率为(原料中含有的多糖按100%计)、总固体(有效成分含量不变的情况下,总固体量越高则杂质量越多)判断指标、结果如下:
加水量对提取多糖提取率及总固体的影响
加水量(倍) | 多糖提取率(%) | 总固体(%) |
6 | 56.5 | 15.3 |
8 | 72.1 | 21.8 |
10 | 74.2 | 21.1 |
12 | 75.2 | 23.5 |
14 | 75.2 | 35.9 |
16 | 75.8 | 46.2 |
实验结果表明:当加水量低于8倍时,多糖提取较低,总固体量较低,说明有效成分提取不完全;当加水量超过12倍时总固体量大幅度增加,但是多糖的提取率并未增加,说明有大量无效成分溶出;因此,加水量在8-12倍,多糖的提取率及总固体量最为合适,比较适合工业化生产。最终,经提取次数、提取时间、加水量无数种搭配组合进行如上试验,得到本发明的技术方案为加6-15倍量的水,浸提1-4次,每次0.5-3小时,能够得到最佳的提取效果。
实施例三:本发明提供的一种增强免疫力的中药组合物,原材料包括铁皮石斛、党参、白术、茯苓、桑椹,铁皮石斛35份、党参30份、白术30份、茯苓30份、桑椹30份,所述份数均是指该成分在原材料中的重量份数。
将铁皮石斛除外的五味药材,加12倍量的水,浸提3次,每次3小时,合并提取液,提取液100-400目过滤,在真空度-0.08MPa,温度80℃条件下浓缩,精制,干燥至水分质量含量≤5%后备用,铁皮石斛粉碎成粉备用;将干膏粉与所述原材料粉混合均匀,制成软糖、硬糖、软胶囊、含片、咀嚼片、吞服片剂、泡腾片、颗粒剂、粉剂、茶剂、膏剂中任意一种剂型。
实施例四:本发明提供的一种增强免疫力的中药组合物,原材料包括铁皮石斛、党参、白术、茯苓、桑椹,铁皮石斛35份、党参30份、白术30份、茯苓30份、桑椹30份,所述份数均是指该成分在原材料中的重量份数。
将铁皮石斛除外的五味药材,加10倍量的水,浸提3次,每次1.5小时,合并提取液,提取液100-400目过滤,在真空度-0.07MPa,温度60-80℃条件下浓缩,精制,干燥至水分质量含量≤5%后备用,铁皮石斛粉碎成粉备用;将干膏粉与所述原材料粉混合均匀,制成软糖、硬糖、软胶囊、含片、咀嚼片、吞服片剂、泡腾片、颗粒剂、粉剂、茶剂、膏剂中任意一种剂型。
实施例五:本发明提供的一种增强免疫力的中药组合物,原材料包括铁皮石斛、党参、白术、茯苓、桑椹,铁皮石斛55份、党参45份、白术45份、茯苓45份、桑椹45份,所述份数均是指该成分在原材料中的重量份数。
将铁皮石斛、党参、白术、茯苓、桑椹粉碎成60-120目以上细粉,混合均匀,制成硬胶囊、丸剂中任意一种剂型。采用这种制备方法,制备步骤少,制备成本低,本发明所选原料粉碎呈细粉时,里面的营养成分也不受影响,仍能很好的互相混合起到协同作用。
实施例六:本发明提供的一种增强免疫力的中药组合物,原材料包括铁皮石斛、党参、白术、茯苓、桑椹,铁皮石斛25份、党参15份、白术15份、茯苓15份、桑椹15份,所述份数均是指该成分在原材料中的重量份数。
将铁皮石斛、党参、白术、茯苓、桑椹原材料超微粉碎,混合均匀制成软糖、硬糖、软胶囊、含片、咀嚼片、吞服片剂、颗粒剂、粉剂、茶剂、膏剂、糕点中任意一种剂型。采用这种制备方法,制备步骤少,制备成本低,本发明所选原料超微粉碎时,里面的营养成分也不受影响,仍能很好的互相混合起到协同作用。
实施例七:本发明提供的一种增强免疫力的中药组合物,原材料包括铁皮石斛、党参、白术、茯苓、桑椹,铁皮石斛45份、党参25份、白术25份、茯苓25份、桑椹25份,所述份数均是指该成分在原材料中的重量份数。
将原材料铁皮石斛、党参、白术、茯苓、桑椹粉碎成粗粉,用质量浓度为15%的酒浸泡或渗滤原材料,原材料与酒的体积比为1:10,浸泡或渗滤后过滤后配制成质量浓度为15-45%的酒剂。泡成酒剂是最为简单的方法,本发明所选择的这些原材料浸泡在酒中没有产生其它毒副作用的物质,具有协同地显著提高免疫力的作用。
以下列举试验用以说明本发明选择的酒的质量浓度渗滤或浸泡原材料的有益效果,根据原料性质及其有效成分,分别以0%(纯水),15%,30%,45%,60%酒为溶剂均以15倍原材料的量进行渗滤,渗滤后密封保存30天,以多糖含量、及是否含有微生物来判断。
根据试验结果结合酒类剂型要求,本中药组合物酒类选择用酒的质量浓度为15-45%,渗滤或浸泡,并配制成15-45%的产品,既能保证本中药组合物有效成分的充分溶出,又能保证产品质量,且提供不同浓度的产品更适合市场需求。
实施例八:本发明提供的一种增强免疫力的中药组合物,原材料包括铁皮石斛、党参、白术、茯苓、桑椹,铁皮石斛30份、党参40份、白术20份、茯苓40份、桑椹40份,所述份数均是指该成分在原材料中的重量份数。
将原材料铁皮石斛、党参、白术、茯苓、桑椹粉碎成粗粉,用质量浓度为45%的酒浸泡或渗滤原材料,原材料与酒的体积比为1:20,浸泡或渗滤后过滤后配制成质量浓度为15-45%的酒剂。泡成酒剂是最为简单的方法,本发明所选择的这些原材料浸泡在酒中没有产生其它毒副作用的物质,具有协同地显著提高免疫力的作用。
实施例九:本发明提供的一种增强免疫力的中药组合物,原材料包括铁皮石斛、党参、白术、茯苓、桑椹,铁皮石斛50份、党参20份、白术40份、茯苓17份、桑椹17份,所述份数均是指该成分在原材料中的重量份数。
将原材料铁皮石斛、党参、白术、茯苓、桑椹粉碎成粗粉,用质量浓度为30%的酒浸泡或渗滤原材料,原材料与酒的体积比为1:15,浸泡或渗滤后过滤后配制成质量浓度为10-45%的酒剂。泡成酒剂是最为简单的方法,本发明所选择的这些原材料浸泡在酒中没有产生其它毒副作用的物质,具有协同地显著提高免疫力的作用。
以上所述仅为本发明的优选实施例而已,并不用于限制本发明,对于本领域的技术人员来说,本发明可以有各种更改和变化。凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (7)
1.一种增强免疫力的中药组合物,其特征在于,该中药组合物原材料包括铁皮石斛、党参、白术、茯苓、桑椹。
2.根据权利要求1所述增强免疫力的中药组合物,其特征在于,铁皮石斛20-60份、党参10-50份、白术10-50份、茯苓10-50份、桑椹10-50份,所述份数均是指该成分在原材料中的重量份数。
3.一种制备权利要求1-2任一项所述中药组合物的方法,其特征在于,将铁皮石斛除外的五味药材,加6-15倍量的水,浸提1-4次,每次0.5-3小时,合并提取液,提取液100-400目过滤,在真空度-0.06~-0.08MPa,温度60-80℃条件下浓缩,精制,干燥至水分质量含量≤5%后备用,铁皮石斛粉碎成粉备用;将干膏粉与所述原材料粉混合均匀,制成软糖、硬糖、软胶囊、含片、咀嚼片、吞服片剂、泡腾片、颗粒剂、粉剂、茶剂、膏剂中任意一种剂型。
4.一种制备权利要求1-2任一项所述中药组合物的方法,其特征在于,将铁皮石斛、党参、白术、茯苓、桑椹原材料加水浸提,原材料与水的质量比为1:6-15,提取1-4次,每次0.5-3小时,合并提取液,过滤、浓缩,制成口服液、糖浆、饮料、酒剂中任意一种剂型。
5.一种制备权利要求1-2任一项所述中药组合物的方法,其特征在于,将铁皮石斛、党参、白术、茯苓、桑椹粉碎成60-120目以上细粉,混合均匀,制成硬胶囊、丸剂中任意一种剂型。
6.一种制备权利要求1-2任一项所述中药组合物的方法,其特征在于,将铁皮石斛、党参、白术、茯苓、桑椹原材料超微粉碎,混合均匀制成软糖、硬糖、软胶囊、含片、咀嚼片、吞服片剂、颗粒剂、粉剂、茶剂、膏剂、糕点中任意一种剂型。
7.一种制备权利要求1-2任一项所述中药组合物的方法,其特征在于,将原材料铁皮石斛、党参、白术、茯苓、桑椹粉碎成粗粉,用质量浓度为10-50%的酒浸泡或渗滤原材料,原材料与酒的体积比为1:10-20,浸泡或渗滤后过滤后配制成质量浓度为10-50%的酒剂。
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