CN108159144A - A kind of particles for eliminating phlegm and stopping cough and preparation method thereof - Google Patents
A kind of particles for eliminating phlegm and stopping cough and preparation method thereof Download PDFInfo
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- CN108159144A CN108159144A CN201711314015.5A CN201711314015A CN108159144A CN 108159144 A CN108159144 A CN 108159144A CN 201711314015 A CN201711314015 A CN 201711314015A CN 108159144 A CN108159144 A CN 108159144A
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- particles
- eliminating phlegm
- weight
- stopping cough
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- 206010011224 Cough Diseases 0.000 title claims abstract description 65
- 206010062717 Increased upper airway secretion Diseases 0.000 title claims abstract description 55
- 208000026435 phlegm Diseases 0.000 title claims abstract description 55
- 239000002245 particle Substances 0.000 title claims abstract description 54
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 239000006071 cream Substances 0.000 claims abstract description 12
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 238000009835 boiling Methods 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 4
- 239000011812 mixed powder Substances 0.000 claims description 4
- 239000000284 extract Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000001606 7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)chroman-4-one Substances 0.000 claims description 2
- 239000000853 adhesive Substances 0.000 claims description 2
- 230000001070 adhesive effect Effects 0.000 claims description 2
- 235000019441 ethanol Nutrition 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- DFPMSGMNTNDNHN-ZPHOTFPESA-N naringin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC=2C=C3O[C@@H](CC(=O)C3=C(O)C=2)C=2C=CC(O)=CC=2)O[C@H](CO)[C@@H](O)[C@@H]1O DFPMSGMNTNDNHN-ZPHOTFPESA-N 0.000 claims description 2
- 229940052490 naringin Drugs 0.000 claims description 2
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- 238000002386 leaching Methods 0.000 claims 1
- 206010036790 Productive cough Diseases 0.000 abstract description 15
- 206010006451 bronchitis Diseases 0.000 abstract description 10
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- 201000010099 disease Diseases 0.000 abstract description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 8
- GBFLZEXEOZUWRN-VKHMYHEASA-N S-carboxymethyl-L-cysteine Chemical compound OC(=O)[C@@H](N)CSCC(O)=O GBFLZEXEOZUWRN-VKHMYHEASA-N 0.000 abstract description 7
- 208000006673 asthma Diseases 0.000 abstract description 7
- 229960004399 carbocisteine Drugs 0.000 abstract description 7
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- 230000001225 therapeutic effect Effects 0.000 abstract description 5
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- 150000001875 compounds Chemical class 0.000 abstract description 3
- 244000248349 Citrus limon Species 0.000 abstract 1
- 235000005979 Citrus limon Nutrition 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 abstract 1
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Classifications
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The present invention relates to electuary technical fields, more particularly to a kind of particles for eliminating phlegm and stopping cough and preparation method thereof, the particles for eliminating phlegm and stopping cough includes 40 50 parts by weight carbocisteines, 80 160 parts by weight loguat leaf dry creams, 100 120 parts by weight of sucrose, 15 parts by weight of lemon acid, 0.5 1 parts by weight saccharin sodiums and 0 10 parts by weight addition auxiliary agent, the particles for eliminating phlegm and stopping cough of the present invention is compound by the Chinese and Western of carbocisteine and loguat leaf dry cream, acute exacerbation of chronic obstructive pulmonary disease can be efficiently reduced, to treating bronchitis, sputum stiff caused by the diseases such as bronchial asthma, expectoration or expiratory dyspnea have good therapeutic effect, acute exacerbation of chronic obstructive pulmonary disease can be reduced and suitable for respiratory tract infection group of people at high risk.
Description
Technical field
The present invention relates to electuary technical fields, and in particular to a kind of particles for eliminating phlegm and stopping cough and preparation method thereof.
Background technology
Cough is one of common symptom of daily life, is the infection of the upper respiratory tract, acute/chronic bronchitis, bronchus expansion
, the main clinical manifestations of the diseases such as pneumonia, pulmonary tuberculosis.《Three-character medical verses are coughed》：" cough does not terminate in lung, and also not from
In lung." exopathogen invades and in lung cause cough, cough up phlegm, treatment is when based on eliminating evil, attention resolving sputum is pleasant, makes the clear gas of phlegm suitable, lung
Gas a surname is smooth.
In Chinese medicine, tendril-leaved fritillary bulb, loguat leaf are common Chinese medicine, also there is more treatment cough or even branch gas at present
The Chinese medicine composition of Guan Yan, such as fritillary-loquat particle, prescription is：Bulbus fritillariae cirrhosae 150g, campanulaceae 150g, loguat leaf 999g, peppermint
Brain 1.13g, almond flavour 0.5ml and other auxiliary materials.Drug clearing heat and freeing lung, the preventing phlegm from forming and stopping coughing, available for treatment cold cough and
Bronchitis.But the drug for treating cough currently on the market is Chinese and Western bulkhead, and Chinese medicine works slowly, and western medicine treatment effect is not
It is good, side effect is big, be unable to reach the part-time effect of sample.
Invention content
In order to overcome shortcoming and defect in the prior art, the purpose of the present invention is to provide it is a kind of it is blending the east and the west,
Acute exacerbation of chronic obstructive pulmonary disease can be efficiently reduced, to phlegm caused by the diseases such as treatment bronchitis, bronchial asthma
Liquid stiff, expectoration or expiratory dyspnea have good therapeutic effect, can reduce acute exacerbation of chronic obstructive pulmonary disease and suitable for breathing
Particles for eliminating phlegm and stopping cough of road infection group of people at high risk and preparation method thereof.
The purpose of the present invention is achieved through the following technical solutions：
A kind of particles for eliminating phlegm and stopping cough includes the raw material of following parts by weight：
The addition auxiliary agent is pigment and/or essence.
The carbocisteine effect of the present invention mainly influences the secretion of bronchus body of gland in cellular level, makes the saliva of low-viscosity
Mucin secretion increases, and full-bodied rock algae mucin generates reduction, thus reduces sputum viscosity, makes it easy to expectoration,
The effect of loguat leaf dry cream is removing heat from the lung to relieve cough and stomach diuresis, quenches the thirst.The particles for eliminating phlegm and stopping cough of the present invention by carbocisteine and
The Chinese and Western of loguat leaf dry cream is compound, can efficiently reduce acute exacerbation of chronic obstructive pulmonary disease, to treatment bronchitis, branch
Sputum stiff caused by the diseases such as san bronchial asthma, expectoration or expiratory dyspnea have good therapeutic effect, can reduce Chronic Obstructive Pulmonary Disease
Sick acute attack and suitable for respiratory tract infection group of people at high risk.
Wherein, the addition auxiliary agent is orange flavor and naringin.
Wherein, the preparation method of the loguat leaf dry cream is：Loguat leaf is taken, is added water to cook three times, filtering, merging filtrate is simultaneously
Filtrate is condensed into the medicinal extract that relative density is 1.21-1.25, medicinal extract is dried under reduced pressure and is done to get to the loguat leaf
Cream.
Wherein, particles for eliminating phlegm and stopping cough further includes the raw material of following parts by weight：
Wherein, particles for eliminating phlegm and stopping cough further includes the raw material of following parts by weight：
Preferably, the particles for eliminating phlegm and stopping cough is made of the raw material of following parts by weight：
Preferably, the particles for eliminating phlegm and stopping cough is made of the raw material of following parts by weight：
Preferably, the particles for eliminating phlegm and stopping cough is made of the raw material of following parts by weight：
Wherein, the preparation method of this kind of particles for eliminating phlegm and stopping cough, includes the following steps：
(1) it crushes：Other raw materials in addition to auxiliary agent is added are crushed；
(2) it mixes：The raw material powder after crushing is taken to carry out physical mixed, obtains mixed-powder；
(3) it pelletizes：The mixed-powder is subjected to boiling granulating to get to hybrid particles；
(4) whole grain：It is mixed toward the hybrid particles and addition auxiliary agent to get to the particles for eliminating phlegm and stopping cough.
Wherein, using ethyl alcohol as adhesive, the dry weight weightlessness of hybrid particles is not more than boiling granulating in the step (3)
0.5%.
The invention further relates to traditional Chinese medicinal components the effect of it is as follows：
Honeysuckle：Sweet in flavor cold in nature, return lung, the heart, stomach are longer than clearing heat and detoxicating, dispelling wind and heat from the body, to control malignant boil, sore, carbuncle, swelling it
Monarch drug in a prescription.
Wild chrysanthemum：Meridian distribution of property and flavor is bitter, pungent, is slightly cold, Return liver, the heart channel of Hang-Shaoyin, has the function of clearing heat and detoxicating, detumescence, can be extensive
For treating anemopyretic cold, pneumonia, diphtheria, gastroenteritis, hypertension, furunculosis carbuncle swells, abscess of throat, wind-fire red eye, dizziness of having a headache
Etc. diseases.
Rhizoma Chuanxiong：It is acrid in flavour and warm in nature.Return liver, courage, pericardium channel, there is the benefits of blood-activating and qi-promoting, wind-expelling pain-stopping.The expansible blood vessel of Rhizoma Chuanxiong improves
Microcirculation.There is calmness, and have apparent and lasting antihypertensive effect；It can inhibit various bacteria.
Radix Astragali：It is sweet in flavor, tepor.Return lung, spleen, liver and kidney channel.There is enhancing body's immunity, treatment syndrome of deficiency of lung qi, the deficiency of vital energy decline
The effect of weak.
Radix Angelicae Pubescentis, acrid flavour, hardship, temperature；Enter lung, spleen, kidney three to pass through, there is the benefits of dispelling wind removing toxic substances, promoting blood circulation, analgesic.
Lepidium seed：Acrid flavour, hardship, it is cold in nature.Enter lung, bladder, large intestine channel.Purging the lung of pathogenic fire sending down abnormally ascending, eliminating phlegm and relieving asthma, inducing diuresis for removing edema expel the heat-evil
By heresy.Cure mainly the dyspnea and cough with excessive sputum of sputum stop up lung, lung carbuncle, oedema, chest and abdomen ponding, difficult urination, chronic cor pulmonale, mental and physical efforts
The asthma of failure is swollen.Also ulcer malignant sore, scrofula tuberculosis are controlled.
Plantain seed：It is sweet in flavor, it is cold in nature.Return liver, kidney, lung, small intestinl channel.Reducing fever and causing diuresis is treating stranguria, excreting dampness antidiarrheal, improving eyesight, eliminating the phlegm.With
In puckery pain of heat gonorrhea, oedema turgor, summer heat damp diarrhea, red eye, swell pain, phlegm-heat cough.
Radix Glycyrrhizae, sweet in flavor, mild-natured, the thoughts of returning home, lung, spleen, stomach are invigorated the spleen and benefited qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain,
The benefits of coordinating the drug actions of a prescription.
The present invention particles for eliminating phlegm and stopping cough further add in using it is clearing heat and detoxicating be length honeysuckle as monarch drug in a prescription, with wild chrysanthemum,
Rhizoma Chuanxiong and Radix Astragali are minister, the benefits of enhancing heat-clearing, and make the present invention particles for eliminating phlegm and stopping cough also have blood-activating and qi-promoting, sedation-analgesia it
Effect promotes absorption of the human body to carbocisteine and loguat leaf dry cream, greatly shortens onset time.
The present invention further adds in Radix Angelicae Pubescentis, lepidium seed, plantain seed and Radix Glycyrrhizae to be made for assistant, is played clearing heat and detoxicating, resolving sputum altogether and is stopped
After cough, the benefits of also acting expelling wind and cold pathogens, Yin nourishing and lung moistening, the thorn of carbocisteine and other Chinese medicines to human body has greatly been mitigated
Swash property.
The particles for eliminating phlegm and stopping cough of the present invention is entirely formulated reasonable compatibility, through dialectical compatibility, helps using mutually assistant, plays altogether
The benefits of clearing heat and detoxicating, preventing phlegm from forming and stopping coughing, expelling wind and cold pathogens, Yin nourishing and lung moistening, to treatment bronchitis, bronchial asthma, chronic obstructive
The diseases such as lung disease have the effect of very high.
The beneficial effects of the present invention are：The carbocisteine effect of the present invention mainly influences bronchus body of gland in cellular level
Secretion, make low-viscosity saliva mucin secrete increase, and full-bodied rock algae mucin generate reduction, thus reduce sputum
Viscosity, makes it easy to expectoration, and the effect of loguat leaf dry cream is removing heat from the lung to relieve cough and stomach diuresis, quenches the thirst.The resolving sputum of the present invention stops
Cough particle is compound by the Chinese and Western of carbocisteine and loguat leaf dry cream, can efficiently reduce the acute hair of Chronic Obstructive Pulmonary Disease
Make, have preferable effect to diseases such as treatment bronchitis, bronchial asthmas, the acute hair of Chronic Obstructive Pulmonary Disease can be reduced
Make and suitable for respiratory tract infection group of people at high risk.
Specific embodiment
For the ease of the understanding of those skilled in the art, with reference to embodiment, the present invention is further illustrated, real
The content that the mode of applying refers to not is limitation of the invention.
Embodiment 1
A kind of particles for eliminating phlegm and stopping cough includes the raw material of following parts by weight：
Embodiment 2
A kind of particles for eliminating phlegm and stopping cough includes the raw material of following parts by weight：
Embodiment 3
A kind of particles for eliminating phlegm and stopping cough includes the raw material of following parts by weight：
Embodiment 4
A kind of particles for eliminating phlegm and stopping cough includes the raw material of following parts by weight：
Embodiment 5
A kind of particles for eliminating phlegm and stopping cough includes the raw material of following parts by weight：
Embodiment 6
A kind of particles for eliminating phlegm and stopping cough includes the raw material of following parts by weight：
Embodiment 7
A kind of particles for eliminating phlegm and stopping cough includes the raw material of following parts by weight：
Embodiment 8
A kind of particles for eliminating phlegm and stopping cough includes the raw material of following parts by weight：
To examine the therapeutic effect of instant particles as Chinese medicine of the present invention, spy carries out following experimental method, and test method is using random point
Group, control experiment method.75 acute bronchitis patients are chosen, this 75 patients are randomly divided into using table of random number method
Two groups.Male 15 in control group 25, women 10, age 5-40 Sui, average age 25 years old.In treatment group A25, male
15, women 10, age 3-35 Sui, average age 22 years old, in treatment group B25, male 15, women 10, age 6-
42 years old, average age 28 years old.
It is promulgated according to State Administration of Traditional Chinese Medicine《Chinese medical disease Standardization of diagnosis and curative effect》Judge curative effect, diagnostic criteria is：
It is effective：Cough, symptom of spitting disappears or substantially reduced, auscultation of lung and Chest X-rays are normal or are clearly better, and lung is different
Often change integrated value and decline >=70%, abnormal physical and chemical index is close to normally；
Effectively：Cough and expectoration mitigates, and other symptoms are substantially reduced, and integrated value declines 30%-69%, and abnormal physical and chemical index has
Improved；
In vain：Without substantially changeing, integrated value declines for cough and other symptoms<30%, abnormal physical and chemical index is not improved.
Wherein, control group is treated using the fritillary-loquat particle that background technology refers to, test group A uses embodiment 1
Particles for eliminating phlegm and stopping cough treated, experiment group B is treated using the preventing phlegm from forming and stopping coughing of embodiment 4, and usage and dosage is out
Mixing in water for oral taking, one time 3 grams, 3 times a day, treatment 7 days after, result of the test is as follows：
As it can be seen that the particles for eliminating phlegm and stopping cough of embodiment 1, the preventing phlegm from forming and stopping coughing of embodiment 4 and fritillary-loquat particle are to acute branch
Tracheitis has certain therapeutic effect, and for curative effect and treatment rate, particles for eliminating phlegm and stopping cough of the invention will be far superior to river
Shellfish loquat particle；And particles for eliminating phlegm and stopping cough of the preventing phlegm from forming and stopping coughing of embodiment 4 also much than embodiment 1 in curative effect is notable, it can
See that the preventing phlegm from forming and stopping coughing of the present invention is significant in efficacy to bronchitis.
Above-described embodiment is the preferable implementation of the present invention, and in addition to this, the present invention can be realized with other manner,
Any obvious replacement is not departed under the premise of present inventive concept within protection scope of the present invention.
Claims (10)
1. a kind of particles for eliminating phlegm and stopping cough, it is characterised in that：Include the raw material of following parts by weight：
The addition auxiliary agent is pigment and/or essence.
2. a kind of particles for eliminating phlegm and stopping cough according to claim 1, it is characterised in that：The addition auxiliary agent for orange flavor and
Naringin.
3. a kind of particles for eliminating phlegm and stopping cough according to claim 1, it is characterised in that：The preparation method of the loguat leaf dry cream
For：Loguat leaf is taken, is added water to cook three times, filtrate is simultaneously condensed into the leaching that relative density is 1.21-1.25 by filtering, merging filtrate
Medicinal extract is dried under reduced pressure to get to the loguat leaf dry cream by cream.
4. according to a kind of particles for eliminating phlegm and stopping cough described in claim 1-3 any one, it is characterised in that：Further include following weight
The raw material of number：
5. a kind of particles for eliminating phlegm and stopping cough according to claim 4, it is characterised in that：Further include the original of following parts by weight
Material：
6. a kind of particles for eliminating phlegm and stopping cough according to claim 5, it is characterised in that：By the raw material group of following parts by weight
Into：
7. a kind of particles for eliminating phlegm and stopping cough according to claim 6, it is characterised in that：By the raw material group of following parts by weight
Into：
8. a kind of particles for eliminating phlegm and stopping cough according to claim 7, it is characterised in that：By the raw material group of following parts by weight
Into：
9. a kind of preparation method of particles for eliminating phlegm and stopping cough described in claim 1-8 any one, it is characterised in that：Including as follows
Step：
(1) it crushes：Other raw materials in addition to auxiliary agent is added are crushed；
(2) it mixes：The raw material powder after crushing is taken to carry out physical mixed, obtains mixed-powder；
(3) it pelletizes：The mixed-powder is subjected to boiling granulating to get to hybrid particles；
(4) whole grain：It is mixed toward the hybrid particles and addition auxiliary agent to get to the particles for eliminating phlegm and stopping cough.
10. a kind of preparation method of particles for eliminating phlegm and stopping cough according to claim 9, it is characterised in that：In the step (3)
For boiling granulating using ethyl alcohol as adhesive, the dry weight weightlessness of hybrid particles is not more than 0.5%.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101288479A (en) * | 2008-05-24 | 2008-10-22 | 红河学院 | Loquat leaf lozenge |
| CN106109396A (en) * | 2016-07-28 | 2016-11-16 | 北京万全德众医药生物技术有限公司 | A kind of carbocisteine syrup and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101288479A (en) * | 2008-05-24 | 2008-10-22 | 红河学院 | Loquat leaf lozenge |
| CN106109396A (en) * | 2016-07-28 | 2016-11-16 | 北京万全德众医药生物技术有限公司 | A kind of carbocisteine syrup and preparation method thereof |
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