CN108158976A - A kind of gel for inhibiting scar growth and preparation method thereof - Google Patents
A kind of gel for inhibiting scar growth and preparation method thereof Download PDFInfo
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- CN108158976A CN108158976A CN201810044233.XA CN201810044233A CN108158976A CN 108158976 A CN108158976 A CN 108158976A CN 201810044233 A CN201810044233 A CN 201810044233A CN 108158976 A CN108158976 A CN 108158976A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/80—Polymers containing hetero atoms not provided for in groups A61K31/755 - A61K31/795
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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Abstract
The present invention relates to a kind of novel gel products for inhibiting scar growth and preparation method thereof; the product smears wound after healing; with the volatilization of moisture; it is cross-linked with each other between film forming matrix, gradually forms protective film diaphragm, and cation is contained on acrylic resin surface; electrostatic force can be formed with cell surface; it is tightly attached to the wound after healing so that smear position non-greasy, glutinous clothing not easy to stick.Antioxidant progresses into the organization internal after healing under the action of bleeding agent in protective film, inhibits self collagen albumen excessive secretion, and improve collagen meshy arrangement by antioxidation.Silicone composition in protective film and by inhibiting the volatilization of tissue moisture at healing, antioxidant is cooperateed with by aquation, the common secretion and arrangement for coordinating collagen in healing of wound tissue has the function that preferably to inhibit scar growth.
Description
Technical field
The present invention relates to field of medical technology, more particularly to a kind of gel for inhibiting scar growth and preparation method thereof.
Background technology
In order to prevent with treatment scar hyperplasia, clinically extensively using pressure therapy.Nineteen eighty-three Perkin etc. is using bullet
Property band compressing scar when in order to prevent the direct friction of elastic webbing and scar and be put into Silica hydrogel between skin and elastic suit
Film, as a result, it has been found that Silica hydrogel (silicone gel) plays the role of preventing scar hyperplasia, effect is much better than the person that is applied alone elastic webbing.
Thus Silica hydrogel has been opened to the inhibiting effect of scar and in widespread attention.
Part silicone gel products have been occurred on the market at present, have been generally divided into：Silicone gel, silicone derivative it is poly-
Close object gel, be included in above two form on the basis of plus back sheet stick class product etc..Since silicone is a kind of in itself
A kind of organosilicon polymer that hydrophobicity is strong, viscosity is larger, so simple is easy to viscous glutinous and pollution clothes using silicone, and
Silicone with back sheet stick class product also tended in using effect it is less desirable (such as：Depressed area, joint part hold
Influence using effect easy to fall off etc.).
Invention content
The technical problems to be solved by the invention are：A kind of gel for inhibiting scar growth and preparation method thereof, solution are provided
The problem of certainly silicone gel products at present on the market easily come off.
In order to solve the above-mentioned technical problem, the technical solution adopted by the present invention is：A kind of the solidifying of inhibition scar growth is provided
Glue is prepared by the raw material of following parts by weight：
3-110 parts of silicone derivatives, 1.6-52 parts of film forming matrix, 0.25-15 parts of antioxidants, 1.25-65 parts of bleeding agents,
0.25-25 parts of emulsifiers and 1-50 parts of purified waters；
The silicone derivative is handed over for dimethyl silicone polymer and ring five dimethyl silicone polymer and dimethyl silicone polymer
Linked polymer, dimethyl silicone polymer, cyclopentasiloxane, octyl group polymethyl siloxane and ring five dimethyl silicone polymer and poly- two
Phenylmethylsiloxane polymers, ring five dimethyl silicone polymer and Dimethicone Crosspolymer, five poly dimethyl silicon of ring
One or more of oxygen alkane and cyclohexasiloxane；
The film forming matrix is cationic acrylic resins, carbomer, collagen peptide, hydroxypropyl cellulose, carboxylic
Any one or a few in sodium carboxymethylcellulose pyce, polyethylene glycol and gelatin；
The antioxidant includes one kind or several in vitamin E, lipoic acid, Bulbus Allii Cepae extract, astaxanthin and selenoprotein
Kind；
The bleeding agent includes menthol, camphor, urea, ethyl alcohol, dimethyl sulfoxide (DMSO), propylene glycol, ethyl acetate, fat
In acid, oleic acid, linoleic acid, laruyl alcohol, lauric acid, cationic surface active agent, anionic surfactant and phosphatide
It is one or more of；
The emulsifier is cetyl polyethylene glycol, has polyethylene oxide and polyoxy propane copolymer, loses sorbitan fatty acid
Ester, sucrose fatty ester, polyoxyethylene aliphatic alcohol ether, poly-for polyoxyethylene fatty alcohol ether, polyglyceryl fatty acid ester, magnesium stearate,
Anhydrous sorbitol palmitate, sorbitan trioleate, polyoxyethylene stearyl alcohol ether, Brij92, polyoxy second
Alkene beeswax, Emulsifier EL-60, Glucate SS, cetyl polyethylene glycol, isostearic acid monoglyceride
One or more of.
The present invention also provides a kind of preparation methods for the gel that scar is inhibited to grow, and include the following steps：
S1：Silicone derivative is uniformly mixed, puts into material-compound tank；
S2：Film forming matrix, antioxidant, bleeding agent are proportionally dissolved respectively, emulsifier is added in, using homogeneous
Machine disperses 10-30 minutes, obtains dispersion liquid；
S3：Obtained dispersion liquid is put into material-compound tank, is mixed with silicone derivative, 10-120 is emulsified using emulsifying device
Minute, the gel of the scar that is inhibited growth.
The beneficial effects of the present invention are：The present invention relates to a kind of novel gel products and its system that inhibit scar growth
Preparation Method, the product smear wound after healing, with the volatilization of moisture, are cross-linked with each other between film forming matrix, are gradually formed
Protective film diaphragm, and cation is contained on acrylic resin surface, and electrostatic force can be formed with cell surface, is tightly attached to healing
Wound afterwards so that smear position non-greasy, glutinous clothing not easy to stick.In protective film antioxidant under the action of bleeding agent by
The organization internal after healing is gradually entered, self collagen albumen excessive secretion is inhibited, and improve collagen egg by antioxidation
White meshy arrangement.Silicone composition in protective film and by inhibiting the volatilization of tissue moisture at healing, cooperateed with by aquation
Antioxidant, the common secretion and arrangement for coordinating collagen in healing of wound tissue reach and preferably inhibit scar growth
Effect.
Description of the drawings
Fig. 1 is that the scar proliferation index HI calculation of measured data involved in the animal experiment in the present invention in specific embodiment shows
It is intended to.
Specific embodiment
For the technology contents that the present invention will be described in detail, the objects and the effects, below in conjunction with embodiment and coordinate attached
Figure is explained.
The design of most critical of the present invention is：A kind of novel gel products for inhibiting scar growth that the present invention is designed
Wound after healing is smeared, with the volatilization of moisture, is cross-linked with each other between film forming matrix, gradually forms protective film diaphragm, and
Cation is contained on acrylic resin surface, can form electrostatic force with cell surface, be tightly attached to the wound after healing, make
Position non-greasy must be smeared, glutinous clothing not easy to stick.
The present invention relates to a kind of gels for inhibiting scar growth, are prepared by the raw material of following parts by weight：
3-110 parts of silicone derivatives, 1.6-52 parts of film forming matrix, 0.25-15 parts of antioxidants, 1.25-65 parts of bleeding agents,
0.25-25 parts of emulsifiers and 1-50 parts of purified waters；
The silicone derivative is handed over for dimethyl silicone polymer and ring five dimethyl silicone polymer and dimethyl silicone polymer
Linked polymer, dimethyl silicone polymer, cyclopentasiloxane, octyl group polymethyl siloxane and ring five dimethyl silicone polymer and poly- two
Phenylmethylsiloxane polymers, ring five dimethyl silicone polymer and Dimethicone Crosspolymer, five poly dimethyl silicon of ring
One or more of oxygen alkane and cyclohexasiloxane；
The film forming matrix is cationic acrylic resins, carbomer, collagen peptide, hydroxypropyl cellulose, carboxylic
Any one or a few in sodium carboxymethylcellulose pyce, polyethylene glycol and gelatin；
The antioxidant includes one kind or several in vitamin E, lipoic acid, Bulbus Allii Cepae extract, astaxanthin and selenoprotein
Kind；
The bleeding agent includes menthol, camphor, urea, ethyl alcohol, dimethyl sulfoxide (DMSO), propylene glycol, ethyl acetate, fat
In acid, oleic acid, linoleic acid, laruyl alcohol, lauric acid, cationic surface active agent, anionic surfactant and phosphatide
It is one or more of；
The emulsifier is cetyl polyethylene glycol, has polyethylene oxide and polyoxy propane copolymer, loses sorbitan fatty acid
Ester, sucrose fatty ester, polyoxyethylene aliphatic alcohol ether, poly-for polyoxyethylene fatty alcohol ether, polyglyceryl fatty acid ester, magnesium stearate,
Anhydrous sorbitol palmitate, sorbitan trioleate, polyoxyethylene stearyl alcohol ether, Brij92, polyoxy second
Alkene beeswax, Emulsifier EL-60, Glucate SS, cetyl polyethylene glycol and isostearic acid monoglyceride
One or more of.
The advantageous effect of the gel of above-mentioned inhibition scar growth is：The present invention has devised a kind of novel inhibition scar
The gel products of growth, the product are smeared wound after healing, with the volatilization of moisture, are mutually handed between film forming matrix
Connection gradually forms protective film diaphragm, and cation is contained on acrylic resin surface, and electrostatic force can be formed with cell surface,
It is tightly attached to the wound after healing so that smear position non-greasy, glutinous clothing not easy to stick.Antioxidant is in bleeding agent in protective film
Under the action of progress into the organization internal after healing, by antioxidation inhibit self collagen albumen excessive secretion, and
Improve collagen meshy arrangement.Silicone composition in protective film and by inhibiting the volatilization of tissue moisture at healing, pass through water
Cooperation collaboration antioxidant, the common secretion and arrangement for coordinating collagen in healing of wound tissue reach better inhibition
The effect of scar growth.
Further, in the gel formula of above-mentioned inhibition scar growth, the silicone derivative by following parts by weight original
Material is configured：
1-50 parts of dimethyl silicone polymers and ring five dimethyl silicone polymer and Dimethicone Crosspolymer, 1-
30 parts of dimethyl silicone polymers and 1-30 parts of cyclopentasiloxanes.
Further, in the gel formula of above-mentioned inhibition scar growth, the film forming matrix by following parts by weight raw material
It is configured：
1-20 parts of acrylic resins, 0.1-2 parts of carbomers and 0.5-30 parts of collagen peptides.
Further, in the gel formula of above-mentioned inhibition scar growth, the antioxidant by following parts by weight raw material
It is configured：
0.1-5 parts of vitamin Es, 0.1-5 parts of lipoic acids and 0.05-5 parts of Bulbus Allii Cepae extracts.
Further, in the gel formula of above-mentioned inhibition scar growth, the bleeding agent is matched by the raw material of following parts by weight
It puts：
0.05-5 parts of menthols, 0.1-10 parts of camphors, 0.1-20 parts of urea and 1-30 parts of ethyl alcohol.
Further, in the gel formula of above-mentioned inhibition scar growth, the emulsifier is cetyl polyethylene glycol.
Further, the gel formula of above-mentioned inhibition scar growth is by 3-110 parts of silicone derivatives, 1.6-52 parts of film forming bases
Matter, 0.25-15 part antioxidant, 1.25-65 parts of bleeding agents, 0.25-25 parts of emulsifiers and 1-50 parts of purified waters are prepared：
The silicone derivative is configured by the raw material of following parts by weight：1-50 parts of dimethyl silicone polymers and ring five are poly-
Dimethyl siloxane and Dimethicone Crosspolymer, 1-30 part dimethyl silicone polymer and 1-30 parts of five silica of ring
Alkane；
The film forming matrix is configured by the raw material of following parts by weight：1-20 parts of acrylic resins, 0.1-2 parts of card waves
Nurse and 0.5-30 parts of collagen peptides；
The antioxidant is configured by the raw material of following parts by weight：0.1-5 parts of vitamin Es, 0.1-5 parts of lipoic acids and
0.05-5 parts of Bulbus Allii Cepae extracts；
The bleeding agent is configured by the raw material of following parts by weight：0.05-5 parts of menthols, 0.1-10 parts of camphors, 0.1-
20 parts of urea and 1-30 parts of ethyl alcohol；
The emulsifier is cetyl polyethylene glycol.
Further, the gel formula of above-mentioned inhibition scar growth is prepared by following raw material：
25g dimethyl silicone polymers and ring five dimethyl silicone polymer and Dimethicone Crosspolymer, 15g gather
Dimethyl siloxane, 15g cyclopentasiloxanes, 10g acrylic resins, 1g carbomers, 15g collagen peptides, 2.5g vitamins
E, 3g octanoic acids, 3g Bulbus Allii Cepae extracts, 3g menthols, 5g camphors, 10g urea, 15g ethyl alcohol, 15g cetyls polyethylene glycol and 25g
Purified water.
A kind of preparation method for the gel that scar is inhibited to grow, includes the following steps：
S1：Silicone derivative is uniformly mixed, puts into material-compound tank；
S2：Film forming matrix, antioxidant, bleeding agent are proportionally dissolved respectively, emulsifier is added in, using homogeneous
Machine disperses 10-30 minutes, obtains dispersion liquid；
S3：Obtained dispersion liquid is put into material-compound tank, is mixed with silicone derivative, 10-120 is emulsified using emulsifying device
Minute, the gel of the scar that is inhibited growth.
Embodiment 1
The gel formula of scar growth is inhibited to be prepared by following raw material：
25g dimethyl silicone polymers and ring five dimethyl silicone polymer and Dimethicone Crosspolymer, 15g gather
Dimethyl siloxane, 15g cyclopentasiloxanes, 10g acrylic resins, 1g carbomers, 15g collagen peptides, 2.5g vitamins
E, 3g octanoic acids, 3g Bulbus Allii Cepae extracts, 3g menthols, 5g camphors, 10g urea, 15g ethyl alcohol, 15g cetyls polyethylene glycol and 25g
Purified water.
Embodiment 2
The gel formula of scar growth is inhibited to be prepared by following raw material：
1g dimethyl silicone polymers and ring five dimethyl silicone polymer and Dimethicone Crosspolymer, 1g poly- two
Methylsiloxane, 1g cyclopentasiloxanes, 1g acrylic resins, 0.1g carbomers, 0.5g collagen peptides, 0.1g vitamin Es,
0.1g octanoic acids, 0.05g Bulbus Allii Cepae extracts, 0.05g menthols, 0.1g camphors, 0.1g urea, 1g ethyl alcohol, the poly- second of 0.25g cetyls
Glycol and 1g purified waters.
Embodiment 3
The gel formula of scar growth is inhibited to be prepared by following raw material：
50g dimethyl silicone polymers and ring five dimethyl silicone polymer and Dimethicone Crosspolymer, 30g gather
Dimethyl siloxane, 30g cyclopentasiloxanes, 20g acrylic resins, 20g carbomers, 30g collagen peptides, 5g vitamin Es,
5g octanoic acids, 5g Bulbus Allii Cepae extracts, 55g menthols, 10g camphors, 20g urea, 30g ethyl alcohol, 25g cetyls polyethylene glycol and 50g
Purified water.
Embodiment 4
A kind of preparation method for the gel that scar is inhibited to grow, includes the following steps：
S1：Silicone derivative is uniformly mixed, puts into material-compound tank；
S2：Film forming matrix, antioxidant, bleeding agent are proportionally dissolved respectively, emulsifier is added in, using homogeneous
Machine disperses 20 minutes, obtains dispersion liquid；
S3：Obtained dispersion liquid is put into material-compound tank, is mixed with silicone derivative, 60 points are emulsified using emulsifying device
Clock, the gel of the scar that is inhibited growth.
Embodiment 5
A kind of preparation method for the gel that scar is inhibited to grow, includes the following steps：
S1：Silicone derivative is uniformly mixed, puts into material-compound tank；
S2：Film forming matrix, antioxidant, bleeding agent are proportionally dissolved respectively, emulsifier is added in, using homogeneous
Machine disperses 10 minutes, obtains dispersion liquid；
S3：Obtained dispersion liquid is put into material-compound tank, is mixed with silicone derivative, 10 points are emulsified using emulsifying device
Clock, the gel of the scar that is inhibited growth.
A kind of preparation method for the gel that scar is inhibited to grow, includes the following steps：
S1：Silicone derivative is uniformly mixed, puts into material-compound tank；
S2：Film forming matrix, antioxidant, bleeding agent are proportionally dissolved respectively, emulsifier is added in, using homogeneous
Machine disperses 30 minutes, obtains dispersion liquid；
S3：Obtained dispersion liquid is put into material-compound tank, is mixed with silicone derivative, 120 points are emulsified using emulsifying device
Clock, the gel of the scar that is inhibited growth.
Animal experiment：
Using rabbits hypertrophic scars model, inhibiting effect of the product prepared in the present invention to scar is directly proved.
1st, experiment condition：
A new zealand white rabbit 32) is selected, 2.3~2.5kg, rabbit ear perfects no deformity, and male and female are unlimited；
B) physiological saline (negative group), simple silicone product (control group -1), bleomycin ointment (control group -2, the medicine
Product can destroy DNA replication dna, cell division be prevented to be proliferated, clinically for scar treatment.), product made from the embodiment of the present invention 1
(experimental group)；
3% amobarbital, ultramicrotome, light microscope, hematoxylin eosin staining liquid and Van Gieson dye liquors,
Paraffin, 10% formaldehyde, 50% salpeter solution, vernier caliper, rabbit raising relative article etc..
2nd, Animal Model
A it) is injected using 3% amobarbital (30mg/Kg) auricular vein, visible vessels is avoided along long axis in rabbit ear veutro,
Every ear is taken at 4,2 centimetres of surface of a wound interval ＞, and 2cm*2cm square cutouts, full thickness skin are made in bilateral rabbit ear facies ventralis
Complete resection.The surface of a wound of all animals 90% or so preliminarily forms the hypertrophic scar tissue of protrusion after 3 weeks.
B) group handles 32 rabbits and is randomly divided into 4 groups (8/group), respectively negative group, control group -1, control group -2,
Experimental group, it is early, middle and late daily to smear laboratory sample, each position 0.2g/ml or so three times.
C scar appearance and thickness) were observed and recorded respectively at 4,6,8,12 weeks respectively, and two ear scar positions were cut off after 12 weeks
Tissue, after 10% formaldehyde fixes 48~72 hours, paraffin embedding, slice, dyeing.
3rd, result statistics and observation
Scar proliferation index HI (hypertrophic Index HI)
HE stained slices, with ruler measure is measured microscopically, scar proliferation index are calculated by formula HI=A/B under low power lens
(please referring to attached drawing 1), wherein A represent scar protrusion peak to the vertical height of credulous bone surface, and it is normal that B represents scar periphery
For skin skin edge to the vertical thickness of credulous bone surface, C represents rabbit cartilage；
Fibroblast density NA (numerical density on area)
400 times of light Microscopic observation HE, VG stained slices, central superficial part, central deep in scar, each random choosing in both sides
10 rectangular field of view are taken, range estimation counts and calculates the quantity of unit area FB in slice, is as a result averaged.
Statistical procedures：Experimental data carries out data processing with SPSS statistical softwares.
4th, experimental result and analysis
Direct visual inspection；
Rabbit ear healing surface of a wound early stage, scar show as accessible prototype protrusion patch, and quality is harder, compared to surrounding normal
Skin color is significantly redder.The scar of negative group has apparent proliferative state, the scar of control group -1/2 compared to early stage after 12 weeks
Then show proliferative state unobvious, the scar position majority of experimental group has no that apparent protrusion cuts quality more soft, color and week
Normal skin is enclosed to approach.
Optical microphotograph sem observation result；
After intervening 12 weeks, observe HE stained slices and VG stained slices calculate respectively and count scar proliferation index HI and
Cell density NA, it is as a result as follows：
The comparison (x2 ± s) that each group sample influences rabbit ear scar HI, NA
| Grouping | Quantity | Scar proliferation index | Cell density (a/mm2) |
| Physiological saline | 8 | 4.35±0.78 | 5712±837.1 |
| Simple silicone product | 8 | 3.42±0.37 | 3958±652.8 |
| Bleomycin ointment | 8 | 2.84±0.59 | 3283±109.4 |
| Product of the present invention | 8 | 1.89±0.23 | 2741±351.2 |
This experiment by the histochemical specific stain of HE, VG the results show that compared to the control group (physiological saline group), silicon
Ketone, bleomycin ointment machin experimental group, which have significantly to have, inhibits scar proliferation index HI, and the wherein HI of experimental group declines most
To be notable, the fibroblast quantity in unit area significantly reduces, scar volume-diminished.
5th, above data can be seen that silicone gel product of the invention and simple silicone compared in terms of scar proliferation is inhibited
With drug there is the effect become apparent, and the quantity of fibroblast cell layer can be reduced so that tissue can be normally cured at this
Merge and promote the regularly arranged normal sedimentation with pigment of cell, so the product of the present invention has larger clinical value.
In conclusion the present invention relates to a kind of novel gel products for inhibiting scar growth and preparation method thereof, the production
Product smear wound after healing, with the volatilization of moisture, are cross-linked with each other between film forming matrix, gradually form protective film diaphragm,
And cation is contained on acrylic resin surface, and electrostatic force can be formed with cell surface, is tightly attached to the wound after healing,
So that smear position non-greasy, glutinous clothing not easy to stick.Antioxidant progresses into more under the action of bleeding agent in protective film
Organization internal after conjunction inhibits self collagen albumen excessive secretion, and improve collagen meshy arrangement by antioxidation.
Silicone composition in protective film and by inhibiting the volatilization of tissue moisture at healing, antioxidant is cooperateed with by aquation, altogether
With the secretion and arrangement for coordinating collagen in healing of wound tissue, have the function that scar is preferably inhibited to grow.
The foregoing is merely the embodiment of the present invention, are not intended to limit the scope of the invention, every to utilize this hair
The equivalents that bright description is made directly or indirectly are used in relevant technical field, are similarly included in this hair
In bright scope of patent protection.
Claims (9)
1. a kind of gel for inhibiting scar growth, which is characterized in that be prepared by the raw material of following parts by weight：
3-110 parts of silicone derivatives, 1.6-52 parts of film forming matrix, 0.25-15 parts of antioxidants, 1.25-65 parts of bleeding agents,
0.25-25 parts of emulsifiers and 1-50 parts of purified waters；
The silicone derivative is poly- for dimethyl silicone polymer and ring five dimethyl silicone polymer and dimethyl silicone polymer crosslinking
Close object, dimethyl silicone polymer, cyclopentasiloxane, octyl group polymethyl siloxane and ring five dimethyl silicone polymer and poly dimethyl
Siloxane polymer, ring five dimethyl silicone polymer and Dimethicone Crosspolymer, ring five dimethyl silicone polymer
One or more of with cyclohexasiloxane；
The film forming matrix is cationic acrylic resins, carbomer, collagen peptide, hydroxypropyl cellulose, carboxymethyl
One or more of sodium cellulosate, polyethylene glycol and gelatin；
The antioxidant includes one or more of vitamin E, lipoic acid, Bulbus Allii Cepae extract, astaxanthin and selenoprotein；
The bleeding agent includes menthol, camphor, urea, ethyl alcohol, dimethyl sulfoxide (DMSO), propylene glycol, ethyl acetate, aliphatic acid, oil
One kind in acid, linoleic acid, laruyl alcohol, lauric acid, cationic surface active agent, anionic surfactant and phosphatide or
It is several；
The emulsifier is cetyl polyethylene glycol, has polyethylene oxide and polyoxy propane copolymer, loses Span, sugarcane
Sugar fatty acid ester, polyoxyethylene aliphatic alcohol ether, poly-for polyoxyethylene fatty alcohol ether, polyglyceryl fatty acid ester, magnesium stearate, dehydration mountain
Pears alcohol palmitate, sorbitan trioleate, polyoxyethylene stearyl alcohol ether, Brij92, polyoxyethylene beeswax,
One in Emulsifier EL-60, Glucate SS, cetyl polyethylene glycol and isostearic acid monoglyceride
Kind is several.
2. the gel according to claim 1 for inhibiting scar growth, which is characterized in that the silicone derivative is by following heavy
The raw material of amount part is configured：
1-50 parts of dimethyl silicone polymers and ring five dimethyl silicone polymer and Dimethicone Crosspolymer, 1-30 part
Dimethyl silicone polymer and 1-30 parts of cyclopentasiloxanes.
3. the gel according to claim 1 for inhibiting scar growth, which is characterized in that the film forming matrix is by following weight
The raw material of part is configured：
1-20 parts of acrylic resins, 0.1-2 parts of carbomers and 0.5-30 parts of collagen peptides.
4. the gel according to claim 1 for inhibiting scar growth, which is characterized in that the antioxidant is by following weight
The raw material of part is configured：
0.1-5 parts of vitamins of E, 0.1-5 parts of lipoic acids and 0.05-5 parts of Bulbus Allii Cepae extracts.
5. the gel according to claim 1 for inhibiting scar growth, which is characterized in that the bleeding agent is by following parts by weight
Raw material be configured：
0.05-5 parts of menthols, 0.1-10 parts of camphors, 0.1-20 parts of urea and 1-30 parts of ethyl alcohol.
6. the gel according to claim 1 for inhibiting scar growth, which is characterized in that the emulsifier is the poly- second of cetyl
Glycol.
7. it is according to claim 1 inhibit scar growth gel, which is characterized in that by 3-110 parts of silicone derivatives,
1.6-52 parts of film forming matrix, 0.25-15 parts of antioxidants, 1.25-65 parts of bleeding agents, 0.25-25 parts of emulsifiers and 1-50 parts are pure
Change water to be prepared：
The silicone derivative is configured by the raw material of following parts by weight：Five poly- diformazan of 1-50 parts of dimethyl silicone polymers and ring
Radical siloxane and Dimethicone Crosspolymer, 1-30 part dimethyl silicone polymer and 1-30 parts of cyclopentasiloxanes；
The film forming matrix is configured by the raw material of following parts by weight：1-20 parts of acrylic resins, 0.1-2 parts of carbomers and
0.5-30 parts of collagen peptides；
The antioxidant is configured by the raw material of following parts by weight：0.1-5 parts of vitamin Es, 0.1-5 parts of lipoic acids and
0.05-5 parts of Bulbus Allii Cepae extracts；
The bleeding agent is configured by the raw material of following parts by weight：0.05-5 parts of menthols, 0.1-10 parts of camphors, 0.1-20 parts
Urea and 1-30 parts of ethyl alcohol；
The emulsifier is cetyl polyethylene glycol.
8. the gel according to claim 1 for inhibiting scar growth, which is characterized in that be prepared by following raw material：
25g dimethyl silicone polymers and ring five dimethyl silicone polymer and the poly- diformazan of Dimethicone Crosspolymer, 15g
Radical siloxane, 15g cyclopentasiloxanes, 10g acrylic resins, 1g carbomers, 15g collagen peptides, 2.5g vitamin Es, 3g
Octanoic acid, 3g Bulbus Allii Cepae extracts, 3g menthols, 5g camphors, 10g urea, 15g ethyl alcohol, 15g emulsifiers and 25g purified waters.
9. the preparation method of the gel for inhibiting scar growth of any one of a kind of claim 1-8, which is characterized in that including following
Step：
S1：Silicone derivative is uniformly mixed, puts into material-compound tank；
S2：Film forming matrix, antioxidant, bleeding agent are proportionally dissolved respectively, add in emulsifier, using homogenizer point
It dissipates 10-30 minutes, obtains dispersion liquid；
S3：Obtained dispersion liquid is put into material-compound tank, is mixed with silicone derivative, using 10-120 points of emulsifying device emulsification
Clock, the gel of the scar that is inhibited growth.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810044233.XA CN108158976B (en) | 2018-01-17 | 2018-01-17 | Gel for inhibiting growth of scars and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810044233.XA CN108158976B (en) | 2018-01-17 | 2018-01-17 | Gel for inhibiting growth of scars and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108158976A true CN108158976A (en) | 2018-06-15 |
| CN108158976B CN108158976B (en) | 2022-09-23 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110664660A (en) * | 2019-10-18 | 2020-01-10 | 瑞希(重庆)生物科技有限公司 | Scar-resistant composition and preparation method thereof |
| CN110760272A (en) * | 2019-09-20 | 2020-02-07 | 华电电力科学研究院有限公司 | Solid coupling patch for ultrasonic flowmeter measurement and preparation method thereof |
| CN111450111A (en) * | 2020-04-05 | 2020-07-28 | 北京幸福益生再生医学科技有限公司 | Scar silica gel and preparation method thereof |
| CN112138089A (en) * | 2020-11-13 | 2020-12-29 | 郑虹 | Gel formula for treating scars and preparation method thereof |
| CN112843220A (en) * | 2021-01-20 | 2021-05-28 | 温州医科大学附属第一医院 | Reverse protein stone membrane for inhibiting scar formation and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1201798A (en) * | 1997-06-11 | 1998-12-16 | 花王株式会社 | Cationic group-containing copolymer and thickener |
| US20010007079A1 (en) * | 1997-10-17 | 2001-07-05 | Chernoff W. Gregory | Tissue treatment method |
| CN104107162A (en) * | 2013-04-19 | 2014-10-22 | 江苏知原药业有限公司 | Microemulsion-based gel pharmaceutical composition and preparation method thereof |
| CN105012228A (en) * | 2015-08-17 | 2015-11-04 | 郑州和济生物科技股份有限公司 | Hyaluronic acid and silica gel composition for scar prevention and early repair and preparation method of hyaluronic acid and silica gel composition |
| CN105362210A (en) * | 2015-11-19 | 2016-03-02 | 朱坤福 | Scar gel and preparation method thereof |
-
2018
- 2018-01-17 CN CN201810044233.XA patent/CN108158976B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1201798A (en) * | 1997-06-11 | 1998-12-16 | 花王株式会社 | Cationic group-containing copolymer and thickener |
| US20010007079A1 (en) * | 1997-10-17 | 2001-07-05 | Chernoff W. Gregory | Tissue treatment method |
| CN104107162A (en) * | 2013-04-19 | 2014-10-22 | 江苏知原药业有限公司 | Microemulsion-based gel pharmaceutical composition and preparation method thereof |
| CN105012228A (en) * | 2015-08-17 | 2015-11-04 | 郑州和济生物科技股份有限公司 | Hyaluronic acid and silica gel composition for scar prevention and early repair and preparation method of hyaluronic acid and silica gel composition |
| CN105362210A (en) * | 2015-11-19 | 2016-03-02 | 朱坤福 | Scar gel and preparation method thereof |
Non-Patent Citations (5)
| Title |
|---|
| 倪佩红: "《女人一生应该掌握的365个美容知识》", 31 August 2009, 上海：上海科学普及出版社 * |
| 孟胜男等: "《药剂学 在线学习版》", 31 January 2016, 北京：中国医药科技出版社 * |
| 宋黎等: "硅凝胶膜在病理性瘢痕治疗中的应用", 《中国组织工程研究与临床康复》 * |
| 郑俊民: "《经皮给药新剂型》", 31 December 1997, 人民卫生出版社 * |
| 郝岱峰 等: "《创面修复外科住院医师手册》", 31 January 2015, 北京：金盾出版社 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110760272A (en) * | 2019-09-20 | 2020-02-07 | 华电电力科学研究院有限公司 | Solid coupling patch for ultrasonic flowmeter measurement and preparation method thereof |
| CN110664660A (en) * | 2019-10-18 | 2020-01-10 | 瑞希(重庆)生物科技有限公司 | Scar-resistant composition and preparation method thereof |
| CN111450111A (en) * | 2020-04-05 | 2020-07-28 | 北京幸福益生再生医学科技有限公司 | Scar silica gel and preparation method thereof |
| CN112138089A (en) * | 2020-11-13 | 2020-12-29 | 郑虹 | Gel formula for treating scars and preparation method thereof |
| CN112843220A (en) * | 2021-01-20 | 2021-05-28 | 温州医科大学附属第一医院 | Reverse protein stone membrane for inhibiting scar formation and preparation method thereof |
| CN112843220B (en) * | 2021-01-20 | 2022-06-03 | 温州医科大学附属第一医院 | Reverse protein stone membrane for inhibiting scar formation and preparation method thereof |
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