CN108158976B - Gel for inhibiting growth of scars and preparation method thereof - Google Patents
Gel for inhibiting growth of scars and preparation method thereof Download PDFInfo
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- CN108158976B CN108158976B CN201810044233.XA CN201810044233A CN108158976B CN 108158976 B CN108158976 B CN 108158976B CN 201810044233 A CN201810044233 A CN 201810044233A CN 108158976 B CN108158976 B CN 108158976B
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- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A61K9/0012—Galenical forms characterised by the site of application
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Abstract
The invention relates to a novel gel product for inhibiting scar growth and a preparation method thereof, the gel product is smeared on a healed wound, film forming matrixes are mutually crosslinked along with volatilization of water to gradually form a protective film diaphragm, and the surface of acrylic resin contains cations which can form electrostatic force with the surface of cells to be tightly attached to the healed wound, so that the smeared part is not greasy and is not easy to stick clothes. The antioxidant in the protective film gradually enters the inside of the healed tissue under the action of the penetrant, inhibits the excessive secretion of the collagen per se through the antioxidation, and regulates the reticular arrangement of the collagen. The silicone component in the protective film can coordinate the secretion and arrangement of collagen in the healing wound tissue by inhibiting the volatilization of the tissue moisture at the healing part and by the hydration in cooperation with the antioxidant, thereby achieving better effect of inhibiting the growth of scars.
Description
Technical Field
The invention relates to the technical field of medical treatment, in particular to a gel for inhibiting scar growth and a preparation method thereof.
Background
In order to prevent and treat scar hyperplasia, compression therapy is widely used clinically. In 1983, Perkin et al put a silicone gel film between the skin and the elastic suit in order to prevent the elastic band from directly rubbing the scar when the elastic band is used to press the scar, and found that silicone gel has the function of preventing and treating scar hyperplasia, and the effect is much better than that of the elastic band alone. This has revealed the scar-inhibiting effect of silicone gels and has received much attention.
At present, some silicone gel products appear in the market, and are generally divided into: silicone gel, polymer gel of silicone derivative, and application products comprising a backing layer added to the above two forms. Since the silicone is a silicone polymer with strong hydrophobicity and high viscosity, the silicone is easy to stick and pollute clothes when being used alone, and silicone pasting products with backing layers are not ideal in use effect (such as sunken parts, joint parts are easy to fall off to influence the use effect).
Disclosure of Invention
The technical problem to be solved by the invention is as follows: provides a gel for inhibiting scar growth and a preparation method thereof, which solves the problem that the prior silicone gel products on the market are easy to fall off.
In order to solve the technical problems, the invention adopts the technical scheme that: provides a gel for inhibiting scar growth, which is prepared from the following raw materials in parts by weight:
3-110 parts of silicone derivative, 1.6-52 parts of film-forming matrix, 0.25-15 parts of antioxidant, 1.25-65 parts of penetrating agent, 0.25-25 parts of emulsifier and 1-50 parts of purified water;
the silicone derivative is one or more of polydimethylsiloxane, cyclopentadimethylsiloxane and polydimethylsiloxane cross-linked polymer, polydimethylsiloxane, cyclopentasiloxane, octyl-polymethylsiloxane, cyclopentadimethylsiloxane and polydimethylsiloxane polymer, cyclopentadimethylsiloxane and polydimethylsiloxane cross-linked polymer, cyclopentadimethylsiloxane and cyclohexasiloxane;
the film forming matrix is any one or more of cationic acrylic resin, carbomer, collagen peptide, hydroxypropyl cellulose, sodium carboxymethylcellulose, polyethylene glycol and gelatin;
the antioxidant comprises one or more of vitamin E, lipoic acid, onion extract, astaxanthin and selenoprotein;
the penetrating agent comprises one or more of menthol, camphor, urea, ethanol, dimethyl sulfoxide, propylene glycol, ethyl acetate, fatty acid, oleic acid, linoleic acid, lauryl alcohol, lauric acid, cationic surfactant, anionic surfactant and phospholipid;
the emulsifier is one or more of cetyl polyethylene glycol, polyoxyethylene and polyoxypropylene copolymer, sorbitan fatty acid ester, sucrose fatty acid ester, polyoxyethylene fatty alcohol ether, polyoxyethylene polyester fatty alcohol ether, polyglycerol fatty acid ester, magnesium stearate, sorbitan palmitate, sorbitan trioleate, polyoxyethylene stearyl alcohol ether, polyoxyethylene oleyl alcohol ether, polyoxyethylene beeswax, polyoxyethylene castor oil, methyl glucose sesquistearate, cetyl polyethylene glycol and glyceryl monostearate.
The invention also provides a preparation method of the gel for inhibiting scar growth, which comprises the following steps:
s1: uniformly mixing the silicone derivatives, and putting into a mixing tank;
s2: dissolving the film forming matrix, the antioxidant and the penetrating agent according to a proportion respectively, adding the emulsifier, and dispersing for 10-30 minutes by adopting a homogenizer to obtain a dispersion liquid;
s3: and putting the obtained dispersion liquid into a dosing tank, mixing with a silicone derivative, and emulsifying for 10-120 minutes by using an emulsifying device to obtain the gel for inhibiting the growth of scars.
The invention has the beneficial effects that: the invention relates to a novel gel product for inhibiting scar growth and a preparation method thereof, the gel product is smeared on a healed wound, film forming matrixes are mutually crosslinked along with volatilization of water to gradually form a protective film diaphragm, and the surface of acrylic resin contains cations which can form electrostatic force with the surface of cells to be tightly attached to the healed wound, so that the smeared part is not greasy and is not easy to stick clothes. The antioxidant in the protective film gradually enters the inside of the healed tissue under the action of the penetrant, inhibits the excessive secretion of the collagen per se through the antioxidation, and regulates the reticular arrangement of the collagen. The silicone component in the protective film can coordinate the secretion and arrangement of collagen in the healing wound tissue by inhibiting the volatilization of the water of the healing tissue and cooperating with the antioxidant through hydration, thereby achieving better effect of inhibiting the growth of scars.
Drawings
Fig. 1 is a schematic diagram of data obtained from the estimation of the scar proliferation index HI involved in an animal experiment according to an embodiment of the present invention.
Detailed Description
In order to explain technical contents, achieved objects, and effects of the present invention in detail, the following description is made with reference to the accompanying drawings in combination with the embodiments.
The most key concept of the invention is as follows: the novel gel product for inhibiting the growth of scars, which is designed by the invention, is smeared on healed wounds, the film-forming matrixes are mutually crosslinked along with the volatilization of water to gradually form a protective film diaphragm, and the surface of acrylic resin contains cations, so that the acrylic resin can form electrostatic force effect with the surface of cells and is tightly attached to the healed wounds, so that the smeared parts are not greasy and are not easy to stick to clothes.
The invention relates to a gel for inhibiting scar growth, which is prepared from the following raw materials in parts by weight:
3-110 parts of silicone derivatives, 1.6-52 parts of film-forming matrix, 0.25-15 parts of antioxidant, 1.25-65 parts of penetrating agent, 0.25-25 parts of emulsifier and 1-50 parts of purified water;
the silicone derivative is one or more of polydimethylsiloxane, cyclopentadidimethylsiloxane, polydimethylsiloxane cross-linked polymer, polydimethylsiloxane, cyclopentasiloxane, octyl-polymethylsiloxane, cyclopentadidimethylsiloxane, polydimethylsiloxane cross-linked polymer, cyclopentadidimethylsiloxane and cyclohexasiloxane;
the film forming matrix is any one or more of cationic acrylic resin, carbomer, collagen peptide, hydroxypropyl cellulose, sodium carboxymethylcellulose, polyethylene glycol and gelatin;
the antioxidant comprises one or more of vitamin E, lipoic acid, onion extract, astaxanthin and selenoprotein;
the penetrating agent comprises one or more of menthol, camphor, urea, ethanol, dimethyl sulfoxide, propylene glycol, ethyl acetate, fatty acid, oleic acid, linoleic acid, lauryl alcohol, lauric acid, cationic surfactant, anionic surfactant and phospholipid;
the emulsifier is one or more of cetyl polyethylene glycol, polyoxyethylene and polyoxypropylene copolymer, sorbitan fatty acid ester, sucrose fatty acid ester, polyoxyethylene fatty alcohol ether, polyoxyethylene polyester fatty alcohol ether, polyglycerol fatty acid ester, magnesium stearate, sorbitan palmitate, sorbitan trioleate, polyoxyethylene stearyl alcohol ether, polyoxyethylene oleyl alcohol ether, polyoxyethylene beeswax, polyoxyethylene castor oil, methyl glucose sesquistearate, cetyl polyethylene glycol and glyceryl monostearate.
The gel for inhibiting the growth of the scars has the following beneficial effects: the invention designs a novel gel product for inhibiting the growth of scars, the gel product is smeared on healed wounds, film-forming matrixes are mutually crosslinked along with the volatilization of moisture, a protective film diaphragm is gradually formed, and the surface of acrylic resin contains cations, can form electrostatic force with the surface of cells and is tightly attached to the healed wounds, so that the smeared parts are not greasy and are not easy to stick clothes. The antioxidant in the protective film gradually enters the inside of the healed tissue under the action of the penetrant, inhibits the excessive secretion of the collagen per se through the antioxidation, and regulates the reticular arrangement of the collagen. The silicone component in the protective film can coordinate the secretion and arrangement of collagen in the healing wound tissue by inhibiting the volatilization of the water of the healing tissue and cooperating with the antioxidant through hydration, thereby achieving better effect of inhibiting the growth of scars.
Further, in the formula of the gel for inhibiting scar growth, the silicone derivative is prepared from the following raw materials in parts by weight:
1-50 parts of polydimethylsiloxane, cyclopentadimethicone and polydimethylsiloxane cross-linked polymer, 1-30 parts of polydimethylsiloxane and 1-30 parts of cyclopentadisiloxane.
Further, in the gel formula for inhibiting the growth of scars, the film-forming matrix is prepared from the following raw materials in parts by weight:
1-20 parts of acrylic resin, 0.1-2 parts of carbomer and 0.5-30 parts of collagen peptide.
Further, in the formula of the gel for inhibiting scar growth, the antioxidant is prepared from the following raw materials in parts by weight:
0.1-5 parts of vitamin E, 0.1-5 parts of lipoic acid and 0.05-5 parts of onion extract.
Further, in the gel formula for inhibiting scar growth, the penetrant is prepared from the following raw materials in parts by weight:
0.05-5 parts of menthol, 0.1-10 parts of camphor, 0.1-20 parts of urea and 1-30 parts of ethanol.
Further, in the gel formula for inhibiting scar growth, the emulsifier is cetyl polyethylene glycol.
Furthermore, the gel formula for inhibiting the growth of scars is prepared from 3-110 parts of silicone derivatives, 1.6-52 parts of film-forming matrix, 0.25-15 parts of antioxidant, 1.25-65 parts of penetrating agent, 0.25-25 parts of emulsifier and 1-50 parts of purified water:
the silicone derivative is prepared from the following raw materials in parts by weight: 1-50 parts of polydimethylsiloxane, cyclopentadimethicone and polydimethylsiloxane cross-linked polymer, 1-30 parts of polydimethylsiloxane and 1-30 parts of cyclopentadisiloxane;
the film-forming substrate is prepared from the following raw materials in parts by weight: 1-20 parts of acrylic resin, 0.1-2 parts of carbomer and 0.5-30 parts of collagen peptide;
the antioxidant is prepared from the following raw materials in parts by weight: 0.1-5 parts of vitamin E, 0.1-5 parts of lipoic acid and 0.05-5 parts of onion extract;
the penetrant is prepared from the following raw materials in parts by weight: 0.05-5 parts of menthol, 0.1-10 parts of camphor, 0.1-20 parts of urea and 1-30 parts of ethanol;
the emulsifier is cetyl polyethylene glycol.
Further, the gel formula for inhibiting the growth of scars is prepared from the following raw materials:
25g of dimethicone and cyclopentadimethicone and dimethicone crosspolymer, 15g of dimethicone, 15g of cyclopentasiloxane, 10g of acrylic resin, 1g of carbomer, 15g of collagen peptide, 2.5g of vitamin E, 3g of caprylic acid, 3g of onion extract, 3g of menthol, 5g of camphor, 10g of urea, 15g of ethanol, 15g of cetyl polyethylene glycol, and 25g of purified water.
A method for preparing a gel for inhibiting scar growth comprises the following steps:
s1: uniformly mixing the silicone derivatives, and putting into a dosing tank;
s2: dissolving the film forming matrix, the antioxidant and the penetrating agent according to a proportion respectively, adding the emulsifier, and dispersing for 10-30 minutes by adopting a homogenizer to obtain a dispersion liquid;
s3: and putting the obtained dispersion liquid into a dosing tank, mixing with a silicone derivative, and emulsifying for 10-120 minutes by using an emulsifying device to obtain the gel for inhibiting the growth of scars.
Example 1
The gel formula for inhibiting the growth of scars is prepared from the following raw materials:
25g of dimethicone and cyclopentadimethicone and dimethicone crosspolymer, 15g of dimethicone, 15g of cyclopentasiloxane, 10g of acrylic resin, 1g of carbomer, 15g of collagen peptide, 2.5g of vitamin E, 3g of caprylic acid, 3g of onion extract, 3g of menthol, 5g of camphor, 10g of urea, 15g of ethanol, 15g of cetyl polyethylene glycol, and 25g of purified water.
Example 2
The gel formula for inhibiting the growth of scars is prepared from the following raw materials:
1g of dimethicone and cyclopentadimethicone and dimethicone crosspolymer, 1g of dimethicone, 1g of cyclopentasiloxane, 1g of acrylic resin, 0.1g of carbomer, 0.5g of collagen peptide, 0.1g of vitamin E, 0.1g of caprylic acid, 0.05g of onion extract, 0.05g of menthol, 0.1g of camphor, 0.1g of urea, 1g of ethanol, 0.25g of cetyl polyethylene glycol, and 1g of purified water.
Example 3
The gel formula for inhibiting the growth of scars is prepared from the following raw materials:
50g of dimethicone and cyclopentadimethicone and dimethicone crosspolymer, 30g of dimethicone, 30g of cyclopentasiloxane, 20g of acrylic resin, 20g of carbomer, 30g of collagen peptide, 5g of vitamin E, 5g of caprylic acid, 5g of onion extract, 55g of menthol, 10g of camphor, 20g of urea, 30g of ethanol, 25g of cetyl polyethylene glycol and 50g of purified water.
Example 4
A method for preparing gel for inhibiting scar growth comprises the following steps:
s1: uniformly mixing the silicone derivatives, and putting into a mixing tank;
s2: dissolving a film-forming matrix, an antioxidant and a penetrating agent respectively according to a proportion, adding an emulsifier, and dispersing for 20 minutes by adopting a homogenizer to obtain a dispersion liquid;
s3: and putting the obtained dispersion liquid into a dosing tank, mixing the dispersion liquid with a silicone derivative, and emulsifying the mixture for 60 minutes by using an emulsifying device to obtain the gel for inhibiting the growth of scars.
Example 5
A method for preparing a gel for inhibiting scar growth comprises the following steps:
s1: uniformly mixing the silicone derivatives, and putting into a dosing tank;
s2: dissolving a film forming matrix, an antioxidant and a penetrating agent according to a ratio respectively, adding an emulsifier, and dispersing for 10 minutes by using a homogenizer to obtain a dispersion liquid;
s3: and putting the obtained dispersion liquid into a dosing tank, mixing the dispersion liquid with a silicone derivative, and emulsifying the mixture for 10 minutes by using an emulsifying device to obtain the gel for inhibiting the growth of scars.
A method for preparing a gel for inhibiting scar growth comprises the following steps:
s1: uniformly mixing the silicone derivatives, and putting into a mixing tank;
s2: dissolving a film forming matrix, an antioxidant and a penetrating agent according to a ratio respectively, adding an emulsifier, and dispersing for 30 minutes by using a homogenizer to obtain a dispersion liquid;
s3: and putting the obtained dispersion liquid into a dosing tank, mixing the dispersion liquid with a silicone derivative, and emulsifying the mixture for 120 minutes by using an emulsifying device to obtain the gel for inhibiting the growth of scars.
Animal experiments:
the inhibition effect of the product prepared by the invention on scars is directly proved by using a rabbit ear hypertrophic scar model.
1. The experimental conditions are as follows:
A) selecting 32 New Zealand white rabbits (2.3-2.5 kg), wherein the ears of the rabbits are healthy and have no deformity, and the males and females are not limited;
B) normal saline (negative group), simple silicone product (control group-1), bleomycin ointment (control group-2, which can destroy DNA replication and prevent cell division and proliferation, and is used for scar treatment clinically. ) The product obtained in inventive example 1 (experimental group);
3% pentobarbital, microtome, optical microscope, hematoxylin-eosin staining solution, Van Gieseon staining solution, paraffin, 10% formaldehyde, 50% nitric acid solution, vernier caliper, and other feeding related articles for rabbits.
2. Establishment of animal model
A) Intravenous injection is carried out on the ear margin with 3% pentobarbital (30mg/Kg), visible blood vessels are avoided along the long axis at the ventral side of the rabbit ears, 4 parts are taken from each ear, the wound surface interval is more than 2cm, 2cm x 2cm square incisions are made at the ventral side of the rabbit ears at two sides, and the whole skin is completely excised. After 3 weeks, about 90% of the wounds of all animals initially formed raised hypertrophic scar tissue.
B) Group treatment 32 rabbits were randomly divided into 4 groups (8 rabbits/group), negative group, control group-1, control group-2, and experimental group, and the experimental samples were applied three times a day in the morning, in the middle of the day, and in the evening, each part was 0.2g/ml or so.
C) And respectively observing and recording the appearance and the thickness of the scar at 4 weeks, 6 weeks, 8 weeks and 12 weeks, cutting off scar part tissues of two ears after 12 weeks, fixing for 48-72 hours by 10% formaldehyde, and then embedding, slicing and dyeing by paraffin.
3. Results statistics and observations
Scar hyperplasia Index HI (hypertonic Index HI)
Measuring the HE stained section by using a microscope measuring ruler under a low power microscope, and calculating a scar hyperplasia index (please refer to the attached drawing 1) according to a formula HI (HI/B), wherein A represents the vertical height from the highest point of a scar bulge to the surface of an ear cartilage, B represents the vertical thickness from the normal skin margin around the scar to the surface of the ear cartilage, and C represents rabbit cartilage;
fibroblast cell density NA (numerical dense on area)
And observing HE and VG stained sections under a 400-fold optical lens, randomly selecting 10 rectangular visual fields at the central shallow part, the central deep part and the two side parts of the scar, visually counting and calculating the number of FB in unit area in the sections, and taking the average number of the results.
Statistical treatment: experimental data were processed with SPSS statistical software.
4. Results and analysis of the experiments
Direct appearance observation;
in the early stage of rabbit ear healing wound surface, scars are represented by touchable prototype raised plaques, are hard in texture, and are obviously redder in color compared with surrounding normal skin. After 12 weeks, the scar of the negative group has an obvious hyperplasia state in the early stage, the scar of the control group-1/2 has an unobvious hyperplasia state, most scar parts of the experimental group have no obvious bulges, are soft in texture and have a color close to that of the surrounding normal skin.
Observing results by an optical microscope;
observation of HE stained sections and VG stained sections after 12 weeks of intervention, scar hyperplasia index HI and cell density NA were calculated and counted, respectively, as follows:
comparison of Effect of samples from groups on HI and NA scar in Rabbit ear (x2 + -s)
| Grouping | Number of | Index of scar hyperplasia | Cell density (pieces/mm 2) |
| Physiological saline | 8 | 4.35±0.78 | 5712±837.1 |
| Simple silicone product | 8 | 3.42±0.37 | 3958±652.8 |
| Bleomycin ointment | 8 | 2.84±0.59 | 3283±109.4 |
| Products of the invention | 8 | 1.89±0.23 | 2741±351.2 |
The special staining results of HE and VG histochemistry in the experiment show that compared with a control group (normal saline group), silicone, bleomycin ointment and the experiment group can obviously inhibit the scar proliferation index HI, wherein the HI of the experiment group is reduced most obviously, the number of fibroblasts in a unit area is obviously reduced, and the scar volume is reduced.
5. The data show that the silicone gel product has more obvious effect on inhibiting the scar hyperplasia compared with the simple silicone and the medicines, and can reduce the number of fibroblast layers, so that the tissues can be normally healed and the regular arrangement of cells and the normal deposition of pigments are promoted, therefore, the silicone gel product has greater clinical application value.
In conclusion, the invention relates to a novel gel product for inhibiting scar growth and a preparation method thereof, the gel product is smeared on a healed wound, film-forming matrixes are mutually crosslinked along with the volatilization of water to gradually form a protective film diaphragm, and the surface of acrylic resin contains cations, can form electrostatic force effect with the surface of cells and is tightly attached to the healed wound, so that the smeared part is not greasy and is not easy to stick clothes. The antioxidant in the protective film gradually enters the inside of the healed tissue under the action of the penetrant, inhibits the excessive secretion of the collagen per se through the antioxidation, and regulates the reticular arrangement of the collagen. The silicone component in the protective film can coordinate the secretion and arrangement of collagen in the healing wound tissue by inhibiting the volatilization of the water of the healing tissue and cooperating with the antioxidant through hydration, thereby achieving better effect of inhibiting the growth of scars.
The above description is only an example of the present invention, and is not intended to limit the scope of the present invention, and all equivalent modifications made by the present invention in the specification, or directly or indirectly applied to the related technical field, are included in the scope of the present invention.
Claims (2)
1. A gel for inhibiting scar growth, characterized in that,
the preparation method is characterized by comprising the following raw materials:
25g of dimethicone and cyclopentadimethicone and dimethicone crosspolymer, 15g of dimethicone, 15g of cyclopentasiloxane, 10g of cationic acrylic resin, 1g of carbomer, 15g of collagen peptide, 2.5g of vitamin E, 3g of caprylic acid, 3g of onion extract, 3g of menthol, 5g of camphor, 10g of urea, 15g of ethanol, 15g of emulsifier, and 25g of purified water.
2. A method of preparing a scar growth inhibiting gel of claim 1 comprising the steps of:
s1: uniformly mixing the silicone derivatives, and putting into a dosing tank;
s2: dissolving the film forming matrix, the antioxidant and the penetrating agent according to a proportion respectively, adding the emulsifier, and dispersing for 10-30 minutes by adopting a homogenizer to obtain a dispersion liquid;
s3: and putting the obtained dispersion liquid into a dosing tank, mixing with a silicone derivative, and emulsifying for 10-120 minutes by using an emulsifying device to obtain the gel for inhibiting the growth of scars.
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| CN110760272A (en) * | 2019-09-20 | 2020-02-07 | 华电电力科学研究院有限公司 | Solid coupling patch for ultrasonic flowmeter measurement and preparation method thereof |
| CN110664660A (en) * | 2019-10-18 | 2020-01-10 | 瑞希(重庆)生物科技有限公司 | Scar-resistant composition and preparation method thereof |
| CN111450111A (en) * | 2020-04-05 | 2020-07-28 | 北京幸福益生再生医学科技有限公司 | Scar silica gel and preparation method thereof |
| CN112138089A (en) * | 2020-11-13 | 2020-12-29 | 郑虹 | Gel formula for treating scars and preparation method thereof |
| CN112843220B (en) * | 2021-01-20 | 2022-06-03 | 温州医科大学附属第一医院 | Reverse protein stone membrane for inhibiting scar formation and preparation method thereof |
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| CN105012228A (en) * | 2015-08-17 | 2015-11-04 | 郑州和济生物科技股份有限公司 | Hyaluronic acid and silica gel composition for scar prevention and early repair and preparation method of hyaluronic acid and silica gel composition |
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