CN108144031A - A kind of Chinese medicine composition and its preparation process with prophylactic treatment breast disease and breast health-care effect - Google Patents
A kind of Chinese medicine composition and its preparation process with prophylactic treatment breast disease and breast health-care effect Download PDFInfo
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K2236/30—Extraction of the material
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Abstract
The present invention provides a kind of Chinese medicine compositions and its preparation process with prophylactic treatment breast disease and breast health-care effect, active ingredient raw materials and its parts by weight composition of the Chinese medicine composition include 15~60 parts of sage, 0.25~1 part of orange peel, 0.25~1 part of campanulaceae, 0.5~2 part of pueraria lobata, 0.25~1 part of 0.4~1.25 part of rde bean, 0.1~0.7 part of ginger and brown sugar.The preparation process of the Chinese medicine composition include decoct, grinding and etc., specific dosage form can be made as needed, the preparation process is simple, conducive to production, the Chinese medicine composition can not only be effectively prevented and treated the breast diseases such as breast cancer, Mammary proliferation and mastitis, there is the breast health care of food effects such as breast augmentation, pre- sag-resistant, promoting lactation again, this needs that can meet the breast health-care with Contemporary Female and prevent mammary gland disease.
Description
Technical field
The present invention relates to the field of Chinese medicines more particularly to it is a kind of have prophylactic treatment breast disease and breast health-care effect in
Drug composition and its preparation process.
Background technology
Due to the pressure of life, the problems such as needs of postpartum breastfeeding, modern women usually faces the puzzlement of breast disease.
Common breast disease has five major class such as mastitis, the proliferation of mammary gland, mammary gland fibroma, galactoncus, breast cancer, breast disease
Pathogenic factor is more complicated, and such as treatment is not in time or malpractice, it is possible to lesion occur, lead to life danger at any time, now
Society, in women, breast disease is in rate disease occurred frequently.
Strong plentiful chest is that every women dreams of, but for some women, due to congenital malformation, text
Chest size-fits are improper, some women can all be allowed to be unsatisfied with the chest size of itself；Meanwhile the needs of postpartum breastfeeding, it leads
It causes that the female chest of some nursing periods is sagging, chest type is deteriorated, influences the aesthetic feeling of chest；This period can also face no milk and lack milk
Problem causes to be unable to lactation；These all enable the women of nursing period worried.Modern female has some idea of to the needs of breast health-care,
But the mode that prosthese is enlarged the bosom can not obtain perfect chest, traditional tonic or massage manipulation effect and unobvious；Postpartum female
Property because the reason of lactation cannot carry out the health care of breast in time again.
Invention content
The present invention provides a kind of with prophylactic treatment breast disease and breast health-care effect to overcome the technical issues of above-mentioned
Chinese medicine composition and its preparation process, the Chinese medicine composition both can the effective breast disease such as prophylactic treatment Mammary proliferation, mastitis
Disease, and with breast health care of food effects such as breast augmentation, pre- sag-resistants.
The present invention adopts the following technical scheme that realization：
A kind of Chinese medicine composition with prophylactic treatment breast disease and breast health-care effect, the Chinese medicine composition prepare
Raw material includes sage, orange peel, campanulaceae, pueraria lobata, rde bean, ginger, brown sugar.
Preferably, the parts by weight for the preparing raw material composition of the Chinese medicine composition includes 15~60 parts of sage, orange peel
0.25~1 part, 0.25~1 part of campanulaceae, 0.5~2 part of pueraria lobata, 0.4~1.25 part of rde bean, 0.1~0.7 part of ginger and brown sugar
0.25~1 part.
Preferably, the parts by weight for the preparing raw material composition of the Chinese medicine composition includes 40~50 parts of sage, orange peel 0.6
~0.8 part, 0.6~0.8 part of campanulaceae, 1.4~1.6 parts of pueraria lobata, 0.8~1 part of rde bean, 0.4~0.6 part of ginger and brown sugar 0.6
~0.8 part.
Preferably, the parts by weight for preparing raw material of the Chinese medicine composition, which form, includes 45 parts of sage, 0.7 part of orange peel,
0.7 part of 0.7 part of campanulaceae, 1.5 parts of pueraria lobata, 0.9 part of rde bean, 0.5 part of ginger and brown sugar.
The Chinese medicine composition is prepared in raw material, and the parts by weight of sage need to account for the 88- for the mass parts for always preparing raw material
92%.
The preparation process of the Chinese medicine composition with prophylactic treatment breast disease and breast health-care effect, specifically includes
Following steps：
(1) quantitative sage, orange peel, campanulaceae, pueraria lobata are weighed, the water of certain volume is added to decoct 2 times, adds in 8 times for the first time
The water of volume decocts 6 hours, filtering；Second of the water for adding in 6 times of volumes, decocts 5 hours, filtering；Merge filtrate twice, with
It is spare
(2) weigh quantitative rde bean, be dried, fry, be ground to it is powdered, with spare；
(3) weigh quantitative ginger, be dried, be ground to it is powdered, with spare；
(4) the powdered ginger in step (3) is taken, powdered ginger is all poured into 55~70 DEG C of water；It weighs
Quantitative brown sugar is treated to add in brown sugar after the completion of powdered ginger dissolving, spare after the completion of brown sugar dissolving；
(5) mixing step (1) is boiled medicine filtrate, the powdered rde bean of step (2) and step (4) fresh ginger brown sugar liquid, and heating is protected
50~60 DEG C of temperature is held, stirs 15 minutes and mixes, stand 24 hours；It stands liquid and is concentrated under reduced pressure into relative density at 55 DEG C
1.35~1.5 thick paste；
(6) thick paste that step (5) obtains, through different processing methods, can obtain corresponding dosage form medicine according to the needs of dosage form
Object or health products.
The active ingredient of the Chinese medicine composition can be made into drug or the dosage form of health products includes solid beverage, aqua, tea
Agent, powder, granule and tablet etc..
The beneficial effects of the present invention are：
(1) Chinese medicine composition of the invention prepare raw material can effective nourishing yin and supplementing blood, solve swollen breasts, mammary gland embolism etc.
Problem, can the breast diseases such as effectively preventing breast carcinoma or prophylactic treatment Mammary proliferation, mastitis.
(2) prepare raw material, stone, additive etc. of Chinese medicine composition of the invention meet state food production standard,
It can be used as health products；This Chinese medicine composition is taken as health products the effects that can playing U.S. newborn chest enlarge pre- sag-resistant, is adapted to
The needs of Contemporary Female body beautification.
(3) step of preparation process of Chinese medicine composition of the invention is terse, easy to operate, of low cost, meets food guarantor
The needs of strong product large-scale production.
Specific embodiment
The present invention is further described With reference to embodiment.
Embodiment 1：
Prepare raw material and parts by weight composition：45 parts of sage, 0.7 part of orange peel, 0.7 part of campanulaceae, 1.5 parts of pueraria lobata, rde bean
0.9 part, 0.7 part of 0.5 part of ginger and brown sugar.
Preparation process：
(1) 45 parts of sage is weighed, 0.7 part of orange peel, 0.7 part of campanulaceae, 1.5 parts of pueraria lobata adds the water of certain volume to decoct 2
It is secondary, the water of 8 times of volumes is added in for the first time, is decocted 6 hours, filtering；Second of the water for adding in 6 times of volumes, decocts 5 hours, filtering；
Merge filtrate twice, with spare
(2) weigh 0.9 part of rde bean, be dried, fry, be ground to it is powdered, with spare；
(3) weigh 0.5 part of ginger, be dried, be ground to it is powdered, with spare；
(4) the powdered ginger in step (3) is taken, powdered ginger is all poured into 55~70 DEG C of water；It weighs
0.7 part of brown sugar is treated to add in brown sugar after the completion of powdered ginger dissolving, spare after the completion of brown sugar dissolving；
(5) mixing step (1) is boiled medicine filtrate, the powdered rde bean of step (2) and step (4) fresh ginger brown sugar liquid, and heating is protected
50~60 DEG C of temperature is held, is stirred 15 minutes, stands 24 hours；Stand liquid be concentrated under reduced pressure at 55 DEG C relative density 1.35~
1.5 thick paste；
(6) thick paste in step (5) is taken, under vacuum convection drying, crushed, it is encapsulated to obtain capsule.
Embodiment 2：
Prepare raw material and parts by weight composition：35 parts of sage, 0.5 part of orange peel, 0.5 part of campanulaceae, 1.5 parts of pueraria lobata, rde bean
0.7 part, 0.5 part of 0.3 part of ginger and brown sugar.
Preparation process：
(1) 35 parts of sage is weighed, 0.5 part of orange peel, 0.5 part of campanulaceae, 1.5 parts of pueraria lobata adds the water of certain volume to decoct 2
It is secondary, the water of 8 times of volumes is added in for the first time, is decocted 6 hours, filtering；Second of the water for adding in 6 times of volumes, decocts 5 hours, filtering；
Merge filtrate twice, with spare
(2) weigh 0.7 part of rde bean, be dried, fry, be ground to it is powdered, with spare；
(3) weigh 0.3 part of ginger, be dried, be ground to it is powdered, with spare；
(4) the powdered ginger in step (3) is taken, powdered ginger is all poured into 55~70 DEG C of water；It weighs
0.5 part of brown sugar is treated to add in brown sugar after the completion of powdered ginger dissolving, spare after the completion of brown sugar dissolving；
(5) mixing step (1) is boiled medicine filtrate, the powdered rde bean of step (2) and step (4) fresh ginger brown sugar liquid, and heating is protected
50~60 DEG C of temperature is held, is stirred 15 minutes, stands 24 hours；Stand liquid be concentrated under reduced pressure at 55 DEG C relative density 1.35~
1.5 thick paste；
(6) thick paste in step (5) is taken, adds in excipient starch, is uniformly mixed, it is dry, it is compressed into tablet form and tablet is made.
Embodiment 3：
Prepare raw material and parts by weight composition：50 parts of sage, 0.8 part of orange peel, 0.8 part of campanulaceae, 1.6 parts of pueraria lobata, rde bean 1
Part, 0.8 part of 0.6 part of ginger and brown sugar.
Preparation process：
(1) 50 parts of sage is weighed, 0.8 part of orange peel, 0.8 part of campanulaceae, 1.6 parts of pueraria lobata adds the water of certain volume to decoct 2
It is secondary, the water of 8 times of volumes is added in for the first time, is decocted 6 hours, filtering；Second of the water for adding in 6 times of volumes, decocts 5 hours, filtering；
Merge filtrate twice, with spare
(2) weigh 1 part of rde bean, be dried, fry, be ground to it is powdered, with spare；
(3) weigh 0.6 part of ginger, be dried, be ground to it is powdered, with spare；
(4) the powdered ginger in step (3) is taken, powdered ginger is all poured into 55~70 DEG C of water；It weighs
0.8 part of brown sugar is treated to add in brown sugar after the completion of powdered ginger dissolving, spare after the completion of brown sugar dissolving；
(5) mixing step (1) is boiled medicine filtrate, the powdered rde bean of step (2) and step (4) fresh ginger brown sugar liquid, and heating is protected
50~60 DEG C of temperature is held, is stirred 15 minutes, stands 24 hours；Stand liquid be concentrated under reduced pressure at 55 DEG C relative density 1.35~
1.5 thick paste；
(6) thick paste in step (5) is taken, convection drying is ground into blocky or powdered medicinal tea is made；Boiling is used when taking
Water brews, also can decoction, drink conveniently.
Test example 1：Pharmacodynamics test and clinical test
It is secret prescription handed down in the family from generation to generation that Chinese medicine composition of the present invention, which prepares raw material composition, according to popular legend, the Chinese traditional medicine composition
Object is the highest-ranking imperial concubine's daily health caring food spread in Qing Dynasty's imperial palace, is commonly called as " highest-ranking imperial concubine side ", the spy for preparing raw material of the Chinese medicine composition
Effect of seeking peace is as follows：
Sage alias clarke boea herb is Primulaceae, Lysimachia herbaceos perennial.Slight bitter；It is cool in nature.It can heat-clearing profit
It is wet, promoting blood circulation for regulating menstruation；Cure mainly flu, cough spitting of blood, enteritis, dysentery, hepatitis, rheumatic arthritis, dysmenorrhoea, leukorrhea, mastitis, poison
Snake bite, traumatic injury etc..
Orange peel is otherwise known as dried orange peel, is rutaceae orange and its ripe pericarp of variety.It is arduous, temperature；Enter spleen, lung
Through.Can qi-regulating, in tune, eliminating dampness, resolving sputum；Fullness and oppression of chest and abdomen is cured mainly, do not feel like eating vomits hiccup, coughing with a lot of sputum.
Campanulaceae alias burden flower, small bell flower, are herbaceos perennials.Can facilitaing lung, relieving sore-throat, eliminating the phlegm, apocenosis.Cure mainly cough
Abundant expectoration, chest distress, pharyngalgia, hoarse voice, lung carbuncle pyemesis, sore purulence into.
Pueraria lobata is the dry root of legume pueraria lobata, practises and claims elegant jessamine.It is sweet in flavor, pungent, it is cool in nature；It attaches to the lung and stomach meridians.Can expelling pathogenic factors from muscles and skin move back
Heat, promoting eruption promote the production of body fluid to quench thirst, Shengyang Zhixie.
Rde bean alias red bean.It is mild-natured, it is sweet in flavor, sour.It can relax bowel, lowering blood pressure and blood fat, adjust blood glucose, pre- anti-caking
Stone, body building and weight reducing.
Ginger is the fresh rhizome of Zingiber herbaceos perennial ginger.Acrid flavour, slightly warm in nature；Return lung, spleen, stomach.It can inducing diaphoresis
Cold dispelling, warming middle energizer to arrest vomiting, warm lung cough-relieving, removing toxic substances.
Brown sugar is the sugarcane commerieal sugar with honey.Property is sweet, gentle, nontoxic；It is included into liver, spleen.Can embellish lung and in help spleen,
Slow irritability, relieving alcoholism are enriched blood, broken stasis of blood.Trusted subordinate's heat expansion is cured mainly, dry is intended to drink, swelling and sore throat, cough with lung heat, cardiopulmonary and intestine and small intestine
Heat, wine poison.
Pharmacodynamics test：
(1) to the therapeutic effect of the proliferation of mammary gland：Female rats feeding oestradiol benzoate is tested, feeding 30 days takes 30
Proliferation of mammary gland experiment female rats carry out pharmacodynamic experiment.30 experiment female rats are divided into 3 groups as unit of 10；First
Group experimental rat does not process；Second group of experimental rat feeds appropriate 15% rupixiao tablets, rupixiao pian suspension, once a day；Third group is tested
Rat feeds the powder liquid of Chinese medicine composition of the present invention, once a day.After 15 days, pathological observation is carried out to experimental rat,
The symptom of first group of experimental rat proliferation of mammary gland, which is appointed, to be existed, and second group of experimental rat lump in breast becomes smaller, third group experimental rat
Subside a swelling at lump in breast, proliferation of mammary gland symptom subsides.
(2) acute toxicity test：40 experimental rats of weight about 250g are taken, half male and half female is randomly divided into 4 groups,
Per 10 rats of group, first two groups are experimental group, are denoted as group I, experimental group II, experimental group III；4th group is blank control
Group is denoted as control group I.Experimental group Rat Fast can't help water, and after 24 hours, the 1ml for feeding Chinese medicine composition of the present invention respectively dissipates
Agent liquid 3 times, every minor tick 8 hours；Wherein, group I prepares the powder medicine of raw material using the Chinese medicine composition of 4 times of parts by weight
Liquid；Experimental group II prepares the powder liquid of raw material using the Chinese medicine composition of 8 times of parts by weight；Experimental group III uses 12 times of parts by weight
Chinese medicine composition prepare the powder liquid of raw material.Blank control group is not tested drug, 3 group phases of remaining experiment condition and other
Together.In 3 times 3 hours to rat experimental drug, rat physiological reaction is observed；It is anti-to observe and record rat physiology day by day later
Should, observation 2 times, are observed continuously 14 days daily.
The results show that the experimental rat behavioral activity of experimental group and blank control group is showed no exception, without it is dead and in
Malicious experimental rat.It is observed that after 14 days, animal appearance, behavioral activity, the state of mind, fur and colour of skin variation without exception,
Breathe no abnormality seen, nose, eye, oral cavity secretion without exception.
Group I, experimental group II, the rat dosage of experimental group III be respectively a 50kg Coming-of-Age Day dose 80,
160th, 240 times, and experimental rat is administered and is showed no abnormality, toxic reaction or the phenomena of mortality, it is seen that so the present invention is clinical
Dosage is strict safety.
Test example 2：Model case
Model case 1：Chen, female, 38 years old, with hyperplasia of mammary glands, breast had apparent lump, and tenderness takes little Jin
After one course for the treatment of of ball, lump shows slightly reduction, but effect unobvious.Change the capsule for taking the Chinese medicine composition after 20 days, breast
Lump is obviously reduced；The capsule of the Chinese medicine composition is taken after 30 days, lump in breast disappears；Tenderness sense is gradually straight during the course for the treatment of
To disappearance, patient's recovery from illness.
Model case 2：Model, female, 31 years old, white-collar job, the irregular life of chronic dietary was disorderly, and endocrine is caused to be lost
It adjusts, uneven, swollen breasts occurs in breast, and side breast is laid particular stress on, and is diagnosed as cyclomastopathy.Regularity living of following the doctor's advice simultaneously takes
The capsule obtained through refining with Chinese medicine composition of the present invention is after 14 days, and breast restores normal, and pain disappears, cyclomastopathy recovery from illness.
Model case 3：Zhu, female, 35 years old, I primary breast cancer after breast conserving treatment operation is received, was used for a long time
The boiling water that Chinese medicine composition of the present invention is obtained through refining brews medicinal tea and improves, and body gradually restores, breast abnormality that so far there are no, multiple
Abnormal results are confiscated.
Model case 4：Zhang, female, 26 years old, primiparity puerpera produced the latter moon, breast red and swollen heat pain, and body, which plays shiver with cold, to be had
Fever phenomenon is diagnosed as acute mastitis.Using treatment skill milk ejection and take the capsule obtained through refining of Chinese medicine composition of the present invention
Agent 7 days, body no longer generates heat, and breast redness pain disappears, inflammation recovery from illness.
Model case 5：Poplar, female 29 years old, give a birth after March, have distending pain sense, dysilthia in nursing breast, milk amount subtracts
It is few.The boiling water for taking Chinese medicine composition of the present invention brews medicinal tea 15 days, and spargosis pain disappears, and milk amount is restored, can normal lactation.
Test example 3：Breast health-care case
Breast health-care case 1：Zhang, female, 24 years old, bust 75A, because puberty worn for long periods does not conform to the text of itself size
Chest causes breast development bad.For the health products obtained through refining using Chinese medicine composition of the present invention after 3 months, stature fades in plentiful, chest
Tall and straight, bust increases to 75C.
Breast health-care case 2：Mr. Wang, female, 24 years old, bust 70A, build slight of stature, chest congenital malformation.Use this hair
After 1 15th day of a month of health products that bright Chinese medicine composition is obtained through refining, stature is by showing mellow and full, and chest significantly becomes larger, and bust increases to 75B.
Breast health-care case 3：Lee, female, 31 years old, bust 80D, postpartum breastfeeding phase chest is seriously sagging to be extended out, and is leaned on reluctantly
Brassiere maintains.The health products obtained through refining using Chinese medicine composition of the present invention are after 1 month, and chest is gradually restored to antenatal tall and straight gather
It is horizontal.
The above only expresses the preferred embodiment of the present invention, and description is more specific and in detail, but can not be because
This and be interpreted as the limitation to the scope of the claims of the present invention.It should be pointed out that for those of ordinary skill in the art,
Under the premise of not departing from present inventive concept, several deformations can also be made, improves and substitutes, these belong to the protection of the present invention
Range.Therefore, the protection domain of patent of the present invention should be determined by the appended claims.
Claims (7)
- A kind of 1. Chinese medicine composition with prophylactic treatment breast disease and breast health-care effect, which is characterized in that the Chinese medicine The parts by weight for the preparing raw material composition of composition includes 15~60 parts of sage, 0.25~1 part of orange peel, 0.25~1 part of campanulaceae, Pueraria lobota 0.25~1 part of 0.5~2 part of root, 0.4~1.25 part of rde bean, 0.1~0.7 part of ginger and brown sugar.
- 2. Chinese medicine composition according to claim 1, which is characterized in that the weight for preparing raw material of the Chinese medicine composition Part composition includes 40~50 parts of sage, 0.6~0.8 part of orange peel, 0.6~0.8 part of campanulaceae, 1.4~1.6 parts of pueraria lobata, rde bean 0.8~1 part, 0.6~0.8 part of 0.4~0.6 part of ginger and brown sugar.
- 3. Chinese medicine composition according to claim 1, which is characterized in that the weight for preparing raw material of the Chinese medicine composition Part composition includes 45 parts of sage, 0.7 part of orange peel, 0.7 part of campanulaceae, 1.5 parts of pueraria lobata, 0.9 part of rde bean, 0.5 part of ginger with it is red 0.7 part of sugar.
- 4. a kind of preparation process of the Chinese medicine composition with prophylactic treatment breast disease and breast health-care effect, feature exist In specifically including following steps：(1) quantitative sage, orange peel, campanulaceae, pueraria lobata are weighed, adds in the water of 6~8 times of volumes, decocts twice, it is small to decoct 5~6 When, it is spare to merge filtrate twice for filtering；(2) weigh quantitative rde bean, it is dry fry be ground to it is powdered spare；(3) quantitative ginger is weighed, drying and grinding is to powdered spare；(4) step (3) powdered ginger is taken, is dissolved in 55~70 DEG C of water, adds in quantitative brown sugar, until dissolving, spare；(5) step (1) is taken to boil medicine filtrate, the powdered rde bean of step (2) and step (4) fresh ginger brown sugar liquid, in temperature 50~60 It is all mixed at DEG C, after stirring 15 minutes, stands 24 hours；Stand liquid be concentrated under reduced pressure at 55 DEG C relative density 1.35~ 1.5 thick paste；(6) thick paste that step (5) obtains obtains the drug or health products of corresponding dosage form through different processing methods.
- 5. the preparation process of Chinese medicine composition according to claim 4, which is characterized in that the dosage form in the step (6) Including solid beverage, aqua, medicinal tea, powder, granule and tablet.
- 6. the Chinese medicine composition according to claim 1,2 or 3 is preventing or is treating the application in mamm- disease, It is characterized in that, the mamm- disease includes breast cancer, mastitis and the proliferation of mammary gland.
- 7. application of the Chinese medicine composition according to claim 1,2 or 3 on breast health-care, which is characterized in that described Breast health-care includes chest enlarge, puts down vertical and promoting lactation in advance.
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