CN108143879A - A kind of Chinese medicine composition of enriching yin and nourishing kidney and preparation method thereof - Google Patents
A kind of Chinese medicine composition of enriching yin and nourishing kidney and preparation method thereof Download PDFInfo
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- CN108143879A CN108143879A CN201611157163.6A CN201611157163A CN108143879A CN 108143879 A CN108143879 A CN 108143879A CN 201611157163 A CN201611157163 A CN 201611157163A CN 108143879 A CN108143879 A CN 108143879A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a kind of Chinese medicine compositions of enriching yin and nourishing kidney and preparation method thereof, belong to modern Chinese traditional medicine field.A kind of Chinese medicine composition of enriching yin and nourishing kidney, active constituent are prepared from the following raw materials in parts by weight：16 parts of prepared rehmannia root, 6 parts of moutan bark, 8 parts of Chinese yam, 8 parts of Fructus Corni, 6 parts of rhizoma alismatis, 6 parts of Poria cocos.It is characteristic of the invention that：The present invention has obtained the preparation method of active constituent that is reasonable, stablizing according to the physicochemical property of each flavour of a drug ingredient and the result of study of pharmacological action.Using technical solution of the present invention, the drug quality prepared is stably and controllable, curative effect is with existing market sale dosage form compared to significantly improving, the reduction of patient's taking dose.With significant economic and social benefit.
Description
Technical field
The present invention relates to a kind of Chinese medicine compositions of enriching yin and nourishing kidney and preparation method thereof, belong to modern Chinese traditional medicine field.
Background technology
Kidney-yin deficiency is a type of kidney deficiency, refers to due to damage of kidney-YIN, is lost in showed card raw in nourishing, abnormal heat
It waits, wound or insufficiency of natural endowment or excess of sexual intercourse,indulgence in sexual activities are mostly consumed by prolonged illness or crosses caused by the product for taking temperate-dryness misfortune the moon.Card is shown in soreness of waist and knee joint, head
Dizzy tinnitus, insomnia and dreamful sleep is dysphoria in chestpalms-soles, hectic fever night sweat, premature ejaculation of passing out semen, and dry throat cheekbone is red, and red tongue with a little fluid is without tongue, thready rapid pulse etc..It controls
Suitable nourishing yin and lessening fire.
The traditional Chinese medical science thinks that the kidney being the origin of congenital constitution, cloudy essence in kidney, is total source of the whole body yin-fluid.Deficiency of YIN-essence,impairment of YIN-essence can cause various diseases
Disease, such as：Dizziness, tinnitus, soreness and weakness of waist and knees, osteopyrexia and fever are quenched one's thirst (diabetes) etc..Six drugs containing rehmanniae piece is current market sales of
A kind of Chinese medicine of enriching yin and nourishing kidney.For damage of kidney-YIN, dizziness and tinnitus, soreness and weakness of waist and knees, osteopyrexia and fever, night sweat seminal emission quenches one's thirst.
The prescription and preparation method of six drugs containing rehmanniae piece be：Prepared rehmannia root 176g, moutan bark 66g, Chinese yam 88g, Fructus Corni 88g, rhizoma alismatis
66g, Poria cocos 66g.Moutan bark, Fructus Corni, Poria cocos are ground into fine powder, and sieving, mixing, prepared rehmannia root, Chinese yam, rhizoma alismatis add water to cook
Three times, collecting decoction, filtration, filtrate are condensed into cream, mix, dry, pulverize with above-mentioned powder, add right amount of auxiliary materials, mixing is made
Particle, it is dry, it is tabletted, film coating to get.
Invention content
The invention solves first technical problem be to provide a kind of Chinese medicine composition of enriching yin and nourishing kidney.
The invention solves another technical problem be to provide the preparation method of above-mentioned Chinese medicine composition.
To achieve the above object, the present invention uses following technical scheme；
A kind of Chinese medicine composition of enriching yin and nourishing kidney, active constituent are prepared from the following raw materials in parts by weight：Prepared rehmannia root 16
Part, 6 parts of moutan bark, 8 parts of Chinese yam, 8 parts of Fructus Corni, 6 parts of rhizoma alismatis, 6 parts of Poria cocos.
The active constituent is prepared using following methods：
1st, each raw material is weighed by raw material proportioning；Moutan bark, Fructus Corni, Poria cocos are ground into fine powder, sieving, mixing, prepared rehmannia root,
Chinese yam, rhizoma alismatis add water to cook three times, collecting decoction, and filtration, filtrate is condensed into cream, mixes, dry, pulverize with above-mentioned powder, add
Particle is made in right amount of auxiliary materials, mixing, dry, obtains dried object A.
2nd, each raw material is weighed by raw material proportioning；Moutan bark, Fructus Corni, Poria cocos are ground into fine powder, sieving, mixing, prepared rehmannia root,
Chinese yam, rhizoma alismatis add 8 times of amount water to decoct three times, and first and second time is respectively 2 hours, is for the third time 1 hour, and collecting decoction filters, filter
Liquid is condensed into cream, is mixed with above-mentioned powder, low temperature drying, crushes, adds right amount of auxiliary materials, and particle is made in mixing, dry, is done
Dry object A.
Described pharmaceutical composition also contains pharmaceutically acceptable auxiliary material.
The pharmaceutically acceptable auxiliary material is selected from starch, microcrystalline cellulose, sucrose, Aspartame, dextrin, lactose, sugar
Powder, glucose, sodium chloride, sodium cellulose glycolate, crosslinked polyvinylpyrrolidone, magnesium stearate, superfine silica gel powder, vitamin C,
Any one or a few in cysteine, citric acid and sodium sulfite.
The dosage form of the Chinese medicine composition is peroral dosage form, including but not limited to pill, tablet, capsule or oral liquid.Agent
The selection of type and the dosage of auxiliary material belong to the prior art.
A kind of preparation method of the Chinese medicine composition of enriching yin and nourishing kidney：
Weigh 16 parts of prepared rehmannia root, 6 parts of moutan bark, 8 parts of Chinese yam, 8 parts of Fructus Corni, 6 parts of rhizoma alismatis, 6 parts of Poria cocos.Moutan bark, mountain
The fruit of medicinal cornel, Poria cocos are ground into fine powder, and sieving, mixing, prepared rehmannia root, Chinese yam, rhizoma alismatis add water to cook three times, collecting decoction, filter, filter
Liquid is condensed into cream, mixes, dry, pulverize with above-mentioned powder, adds right amount of auxiliary materials, and particle is made in mixing, dry, obtains dried object
A。
Preferably preparation method is：16 parts of prepared rehmannia root, 6 parts of moutan bark, 8 parts of Chinese yam, 8 parts of Fructus Corni, 6 parts of rhizoma alismatis, Poria cocos 6
Part.Moutan bark, Fructus Corni, Poria cocos are ground into fine powder, sieving, mixing, prepared rehmannia root, Chinese yam, rhizoma alismatis, and 8 times of amount water is added to decoct three times,
First and second time is respectively 2 hours, is for the third time 1 hour, collecting decoction, filtration, filtrate is condensed into cream, is mixed with above-mentioned powder, low
Temperature dry, pulverize, and add right amount of auxiliary materials, and particle is made in mixing, dry, obtain dried object A.
A kind of preparation of the Chinese medicine composition of enriching yin and nourishing kidney, said preparation add in pharmacy with above-mentioned active constituents of medicine and can connect
Pharmaceutically acceptable dosage form is made in the auxiliary material received.Needed for the active constituent of the Chinese medicine composition preparation obtained using the present invention
During the various dosage forms of drug, it can be prepared according to the conventional production process of art of pharmacy.Such as by the active constituent with it is a kind of or
Variety carrier mixes, and corresponding dosage form is then made.
It is an advantage of the invention that：The present invention analyzes composition with theory of traditional Chinese medical science, according to the reason of each flavour of a drug ingredient
Change property and pharmacological action, study and obtained the preparation method of active constituent that is reasonable, stablizing.Technical side using the present invention
Case, stable and controllable for quality, curative effect significantly improves compared with existing commercial dosage forms, the pharmaceutical preparation of patient's taking dose reduction, tool
There is significant economic and social benefit.
Technical solution that the present invention will be described in detail by the following examples does not limit the practical range of the present invention with this.
Specific embodiment
Embodiment 1：Prepare Chinese medical extract
First, prescription：Prepared rehmannia root 176g, moutan bark 66g, Chinese yam 88g, Fructus Corni 88g, rhizoma alismatis 66g, Poria cocos 66g.
2nd, preparation method：
Moutan bark, Fructus Corni, Poria cocos are ground into fine powder, sieving, mixing, prepared rehmannia root, Chinese yam, rhizoma alismatis, and 8 times of amount water is added to decoct
Three times, first and second time is respectively 2 hours, is for the third time 1 hour, collecting decoction, filtration, and filtrate is condensed into cream, is mixed with above-mentioned powder
It closes, low temperature drying, crushes, add right amount of auxiliary materials, particle is made in mixing, dry, obtains dried object 350g.
Embodiment 2：Prepare Chinese medical extract
First, prescription：Prepared rehmannia root 176kg, moutan bark 66kg, Chinese yam 88kg, Fructus Corni 88kg, rhizoma alismatis 66kg, Poria cocos 66kg.
2nd, preparation method：
Moutan bark, Fructus Corni, Poria cocos are ground into fine powder, sieving, mixing, prepared rehmannia root, Chinese yam, rhizoma alismatis, and 8 times of amount water is added to decoct
Three times, first and second time is respectively 2 hours, is for the third time 1 hour, collecting decoction, filtration, and filtrate is condensed into cream, is mixed with above-mentioned powder
It closes, low temperature drying, crushes, add right amount of auxiliary materials, particle is made in mixing, dry, obtains dried object 350kg.
Embodiment 3：Prepare tablet
The active constituent 100g that embodiment 1 obtains, adds microcrystalline cellulose 40g, cross-linked pvp 7g, tabletting, and film coating obtains
Tablet, every weight 0.36g.
Embodiment 4：Prepare capsule
The active constituent 1000g that embodiment 2 obtains, adds starch 250g, and encapsulating capsule obtains capsule, every weight 0.50g.
Claims (8)
1. a kind of Chinese medicine composition of enriching yin and nourishing kidney, active constituent are prepared from the following raw materials in parts by weight：16 parts of prepared rehmannia root,
6 parts of moutan bark, 8 parts of Chinese yam, 8 parts of Fructus Corni, 6 parts of rhizoma alismatis, 6 parts of Poria cocos.
2. the Chinese medicine composition of a kind of enriching yin and nourishing kidney according to claim 1, it is characterised in that the active constituent uses
Following methods are prepared：Moutan bark, Fructus Corni, Poria cocos are ground into fine powder, and sieving, mixing, prepared rehmannia root, Chinese yam, rhizoma alismatis add water
It decocting three times, collecting decoction, filtration, filtrate is condensed into cream, mixes, dry, pulverize with above-mentioned powder, adds right amount of auxiliary materials, mixing,
Particle is made, it is dry, obtain dried object A.
3. a kind of Chinese medicine composition of enriching yin and nourishing kidney according to claim 2, it is characterised in that：Moutan bark, Fructus Corni, Fu
Siberian cocklebur is ground into fine powder, sieving, mixing, prepared rehmannia root, Chinese yam, rhizoma alismatis, and 8 times of amount water is added to decoct three times, and first and second time is respectively 2 hours,
Third time is 1 hour, collecting decoction, filtration, and filtrate is condensed into cream, is mixed with above-mentioned powder, low temperature drying, crushes, adds auxiliary material
In right amount, particle is made in mixing, dry, obtains dried object A.
4. a kind of Chinese medicine composition of enriching yin and nourishing kidney according to any one of claims 1 to 3, it is characterised in that：Institute
Belong to drug and also contain pharmaceutically acceptable auxiliary material.
5. a kind of Chinese medicine composition of enriching yin and nourishing kidney according to claim 4, it is characterised in that：The pharmacy is subjected to
Auxiliary material to be selected from starch, microcrystalline cellulose, sucrose, Aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, methylol fine
The plain sodium of dimension, crosslinked polyvinylpyrrolidone, magnesium stearate, superfine silica gel powder, vitamin C, cysteine, citric acid and sodium sulfite
In any one or a few.
6. a kind of Chinese medicine composition of enriching yin and nourishing kidney according to claim 4, it is characterised in that：The Chinese medicine composition
Dosage form is peroral dosage form, including pill, tablet, capsule or oral liquid.
7. a kind of preparation method of the Chinese medicine composition of enriching yin and nourishing kidney, it is characterised in that：16 parts of prepared rehmannia root, 6 parts of moutan bark, Chinese yam
8 parts, 8 parts of Fructus Corni, 6 parts of rhizoma alismatis, 6 parts of Poria cocos.Moutan bark, Fructus Corni, Poria cocos are ground into fine powder, sieving, mixing, prepared rehmannia root,
Chinese yam, rhizoma alismatis add water to cook three times, collecting decoction, and filtration, filtrate is condensed into cream, mixes, dry, pulverize with above-mentioned powder, add
Particle is made in right amount of auxiliary materials, mixing, dry, obtains dried object A.
8. a kind of Chinese medicine composition of enriching yin and nourishing kidney according to claim 1 according to claim 7, feature exist
In：16 parts of prepared rehmannia root, 6 parts of moutan bark, 8 parts of Chinese yam, 8 parts of Fructus Corni, 6 parts of rhizoma alismatis, 6 parts of Poria cocos.Moutan bark, Fructus Corni, Poria cocos
Fine powder is ground into, is sieved, mixing, prepared rehmannia root, Chinese yam, rhizoma alismatis add 8 times of amount water to decoct three times, and first and second time is respectively 2 hours, the
It it is three times 1 hour, collecting decoction filters, and filtrate is condensed into cream, is mixed with above-mentioned powder, low temperature drying, crushes, auxiliary material is added to fit
Particle is made in amount, mixing, dry, obtains dried object A.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611157163.6A CN108143879A (en) | 2016-12-05 | 2016-12-05 | A kind of Chinese medicine composition of enriching yin and nourishing kidney and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611157163.6A CN108143879A (en) | 2016-12-05 | 2016-12-05 | A kind of Chinese medicine composition of enriching yin and nourishing kidney and preparation method thereof |
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| Publication Number | Publication Date |
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| CN108143879A true CN108143879A (en) | 2018-06-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201611157163.6A Pending CN108143879A (en) | 2016-12-05 | 2016-12-05 | A kind of Chinese medicine composition of enriching yin and nourishing kidney and preparation method thereof |
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| CN (1) | CN108143879A (en) |
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- 2016-12-05 CN CN201611157163.6A patent/CN108143879A/en active Pending
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| Date | Code | Title | Description |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| DD01 | Delivery of document by public notice |
Addressee: Longshunrong Pharmaceutical Factory, Tianjin, Zhongxin, Pharmaceutical Group Co. Document name: Notification of before Expiration of Request of Examination as to Substance |
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| DD01 | Delivery of document by public notice | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180612 |
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| WD01 | Invention patent application deemed withdrawn after publication |