CN108143903A - A kind of Chinese medicine composition of softening and resolving hard mass and preparation method thereof - Google Patents
A kind of Chinese medicine composition of softening and resolving hard mass and preparation method thereof Download PDFInfo
- Publication number
- CN108143903A CN108143903A CN201611163988.9A CN201611163988A CN108143903A CN 108143903 A CN108143903 A CN 108143903A CN 201611163988 A CN201611163988 A CN 201611163988A CN 108143903 A CN108143903 A CN 108143903A
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- parts
- radix
- ethyl alcohol
- heating
- raw material
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- 238000002360 preparation method Methods 0.000 title claims abstract description 16
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- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 30
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- 239000010442 halite Substances 0.000 claims abstract description 29
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- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims abstract description 23
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical class OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
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- 230000008901 benefit Effects 0.000 abstract description 3
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- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
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Classifications
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Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
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- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
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- Microbiology (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of Chinese medicine compositions of softening and resolving hard mass and preparation method thereof, belong to modern Chinese traditional medicine field.A kind of Chinese medicine composition of softening and resolving hard mass, active constituent are prepared from the following raw materials in parts by weight：1600 parts of selfheal, 200 parts of fritillaria thunbergii, 200 parts of seaweed, 200 parts of radix ampelopsis, 200 parts of root of Chinese trichosanthes, 200 parts of Fructus Forsythiae, 200 parts of prepared RADIX ET RHIZOMA RHEI, 200 parts of the compound of glauber-salt and liquorice, 200 parts of clam shell (forging), 200 parts of halite, 200 parts of Fructus Aurantii, 200 parts of campanulaceae, 1 part of menthol, 200 parts of glutinous rehmannia, 200 parts of Radix Angelicae Sinensis, 1000 parts of radix scrophulariae, 200 parts of Radix Glycyrrhizae.It is characteristic of the invention that：The present invention has obtained the preparation method of active constituent that is reasonable, stablizing according to the physicochemical property of each flavour of a drug ingredient and the result of study of pharmacological action.Using technical solution of the present invention, the drug quality prepared is stably and controllable, curative effect is with existing market sale dosage form compared to significantly improving, the reduction of patient's taking dose.With significant economic and social benefit.
Description
Technical field
The present invention relates to a kind of Chinese medicine compositions of softening and resolving hard mass and preparation method thereof, belong to modern Chinese traditional medicine field.
Background technology
Scrofula subcutaneous nodule refers to the limitation mass of body surface.The disease is not transported mostly because spleen is weak, and damp phlegm knot gathers to be formed in subcutaneously.Disease
See intradermal raw core, more or less, and mass is not not red warm, and bitterly not hard, what is pushed away is removable, is mainly in neck, lower chin, four limbs and back
Etc..Control preferably with clear phlegm it is gentle based on.The person that is born in upper body part holds wind-heat under the arm more, be born in lower part person then hold under the arm it is damp and hot.It is bright《Careful vegetarian is lost
Book》Volume nine.Have：" subcutaneous nodule, i.e. scrofula, shaoyang channel stagnated fire are tied." Neixiao Luoli Pian is that current market sales of one kind is soft
The Chinese medicine of hard dissipating bind.For scrofula subcutaneous nodule or swollen or pain.
The prescription and preparation method of Neixiao Luoli Pian be：Selfheal 400g, fritillaria thunbergii 50g, seaweed 50g, radix ampelopsis 50g, root of Chinese trichosanthes
50g, Fructus Forsythiae 50g, prepared RADIX ET RHIZOMA RHEI 50g, compound of glauber-salt and liquorice 50g, clam shell (forge) 50g, halite 50g, Fructus Aurantii 50g, campanulaceae 50g, menthol
0.25g, glutinous rehmannia 50g, Radix Angelicae Sinensis 50g, radix scrophulariae 250g, Radix Glycyrrhizae 50g.Halite, fritillaria thunbergii, clam shell, prepared RADIX ET RHIZOMA RHEI, the compound of glauber-salt and liquorice, smallpox
Powder is ground into fine powder, and menthol is dissolved with ethanol in proper amount；Fructus Forsythiae, seaweed, radix ampelopsis, glutinous rehmannia, Radix Glycyrrhizae, radix scrophulariae add water to cook it is secondary,
Selfheal adds water to cook 5 hours, and merging more than decocting liquid is condensed into thick paste；95% ethyl alcohol of Radix Angelicae Sinensis and 60% ethyl alcohol respectively heat back
Stream extraction is primary；Campanulaceae, 60% ethyl alcohol heating and refluxing extraction of Fructus Aurantii.Merging more than ethanol extract recycles ethyl alcohol, is condensed into
Thick paste.Above-mentioned condensed cream is merged, powder and auxiliary material, the mixings such as halite is added in and particle is made, it is dry, add in menthol second
Alcoholic solution, mixing, it is tabletted to get.
Invention content
The invention solves first technical problem be to provide a kind of Chinese medicine composition of softening and resolving hard mass.
The invention solves another technical problem be to provide the preparation method of above-mentioned Chinese medicine composition.
To achieve the above object, the present invention uses following technical scheme；
A kind of Chinese medicine composition of softening and resolving hard mass, active constituent are prepared from the following raw materials in parts by weight：Selfheal
1600 parts, it is 200 parts of fritillaria thunbergii, 200 parts of seaweed, 200 parts of radix ampelopsis, 200 parts of root of Chinese trichosanthes, 200 parts of Fructus Forsythiae, 200 parts of prepared RADIX ET RHIZOMA RHEI, profound bright
200 parts of powder, 200 parts of clam shell (forging), 200 parts of halite, 200 parts of Fructus Aurantii, 200 parts of campanulaceae, 1 part of menthol, 200 parts of glutinous rehmannia, when
Return 200 parts, 1000 parts of radix scrophulariae, 200 parts of Radix Glycyrrhizae.
The active constituent is prepared using following methods：
1st, each raw material is weighed by raw material proportioning；Halite, fritillaria thunbergii, clam shell, prepared RADIX ET RHIZOMA RHEI, the compound of glauber-salt and liquorice, root of Chinese trichosanthes are ground into
Fine powder, menthol are dissolved with ethanol in proper amount；Fructus Forsythiae, seaweed, radix ampelopsis, glutinous rehmannia, Radix Glycyrrhizae, radix scrophulariae add water to cook secondary, and selfheal adds
Water decocts 5 hours, and merging more than decocting liquid is condensed into thick paste；95% ethyl alcohol of Radix Angelicae Sinensis and each heating and refluxing extraction one of 60% ethyl alcohol
It is secondary；Campanulaceae, 60% ethyl alcohol heating and refluxing extraction of Fructus Aurantii.Merging more than ethanol extract recycles ethyl alcohol, is condensed into thick paste.It will
Above-mentioned condensed cream merges, and adds in powder and auxiliary material, the mixings such as halite and particle is made, dry, adds in menthol ethanol solution,
Mixing obtains dried object A.
2nd, each raw material is weighed by raw material proportioning；Halite, fritillaria thunbergii, clam shell, prepared RADIX ET RHIZOMA RHEI, the compound of glauber-salt and liquorice, root of Chinese trichosanthes are ground into
Fine powder, menthol are dissolved with ethanol in proper amount；Fructus Forsythiae, seaweed, radix ampelopsis, glutinous rehmannia, Radix Glycyrrhizae, radix scrophulariae add water to cook secondary, press for the first time
The extraordinarily water of the 10 of raw material weight, heating are boiled to boiling, are kept for 3 hours；Second by raw material weight 8 extraordinarily water, heating boil to
Boiling is kept for 2 hours.Extracting solution is filtered through 100 mesh filters, is placed in receiver, stands 1 hour.Selfheal adds water to cook
It is secondary, it is boiled to boiling, is kept for 3 hours by 10 extraordinarily water, heating of raw material weight for the first time；Second of press raw material weight 8 times
Add water, heating is boiled to boiling, kept for 2 hours.Extracting solution is filtered through 100 mesh filters, is placed in receiver, stands 1 hour.It closes
And above decocting liquid, it is condensed into thick paste.Radix Angelicae Sinensis is secondary with ethyl alcohol heating and refluxing extraction, for the first time by the 3 extraordinarily 95% of raw material weight
Ethyl alcohol, heating and refluxing extraction are kept for 3 hours；Second of 3 extraordinarily 60% ethyl alcohol for pressing raw material weight, heating and refluxing extraction are kept
3 hours.Extracting solution is filtered through 100 mesh filters, is placed in receiver, stands 1 hour.Campanulaceae, Fructus Aurantii are heated to reflux with ethyl alcohol
It extracts secondary.3.5 extraordinarily 60% ethyl alcohol of raw material weight are pressed for the first time, and heating and refluxing extraction is kept for 3 hours.Second by use
Extraordinarily 60% ethyl alcohol of the 2.5 of raw material weight, heating and refluxing extraction are kept for 2 hours, for the third time by extraordinarily 60% second of raw material weight 2
Alcohol, heating and refluxing extraction are kept for 1 hour.Extracting solution is filtered through 100 mesh filters, is placed in receiver, stands 1 hour.Merge
More than ethanol extract recycles ethyl alcohol, is condensed into thick paste.Above-mentioned condensed cream is merged, adds in halite, fritillaria thunbergii, clam shell, it is ripe
Particle is made in the powder such as rheum officinale, the compound of glauber-salt and liquorice, root of Chinese trichosanthes and auxiliary material, mixing, dry, adds in menthol ethanol solution, and mixing obtains
To dried object A.
Described pharmaceutical composition also contains pharmaceutically acceptable auxiliary material.
The pharmaceutically acceptable auxiliary material is selected from starch, microcrystalline cellulose, sucrose, Aspartame, dextrin, lactose, sugar
Powder, glucose, sodium chloride, sodium cellulose glycolate, crosslinked polyvinylpyrrolidone, magnesium stearate, superfine silica gel powder, vitamin C,
Any one or a few in cysteine, citric acid and sodium sulfite.
The dosage form of the Chinese medicine composition is peroral dosage form, including but not limited to pill, tablet, capsule or oral liquid.Agent
The selection of type and the dosage of auxiliary material belong to the prior art.
A kind of preparation method of the Chinese medicine composition of softening and resolving hard mass：
Weigh 1600 parts of selfheal, 200 parts of fritillaria thunbergii, 200 parts of seaweed, 200 parts of radix ampelopsis, 200 parts of root of Chinese trichosanthes, Fructus Forsythiae 200
Part, 200 parts of prepared RADIX ET RHIZOMA RHEI, 200 parts of the compound of glauber-salt and liquorice, 200 parts of clam shell (forging), 200 parts of halite, 200 parts of Fructus Aurantii, 200 parts of campanulaceae, peppermint
1 part of brain, 200 parts of glutinous rehmannia, 200 parts of Radix Angelicae Sinensis, 1000 parts of radix scrophulariae, 200 parts of Radix Glycyrrhizae.Halite, fritillaria thunbergii, clam shell, it is prepared RADIX ET RHIZOMA RHEI, profound bright
Powder, root of Chinese trichosanthes are ground into fine powder, and menthol is dissolved with ethanol in proper amount；Fructus Forsythiae, seaweed, radix ampelopsis, glutinous rehmannia, Radix Glycyrrhizae, radix scrophulariae add decocting
Boil secondary, selfheal adds water to cook 5 hours, and merging more than decocting liquid is condensed into thick paste；95% ethyl alcohol of Radix Angelicae Sinensis and 60% ethyl alcohol are each
Heating and refluxing extraction is primary；Campanulaceae, 60% ethyl alcohol heating and refluxing extraction of Fructus Aurantii.Merging more than ethanol extract recycles ethyl alcohol,
It is condensed into thick paste.Above-mentioned condensed cream is merged, powder and auxiliary material, the mixings such as halite is added in and particle is made, it is dry, it adds in thin
Lotus brain ethanol solution, mixing obtain dried object A.
Preferably preparation method is：1600 parts of selfheal, 200 parts of fritillaria thunbergii, 200 parts of seaweed, 200 parts of radix ampelopsis, root of Chinese trichosanthes
200 parts, 200 parts of Fructus Forsythiae, 200 parts of prepared RADIX ET RHIZOMA RHEI, 200 parts of the compound of glauber-salt and liquorice, 200 parts of clam shell (forging), 200 parts of halite, 200 parts of Fructus Aurantii,
200 parts of campanulaceae, 1 part of menthol, 200 parts of glutinous rehmannia, 200 parts of Radix Angelicae Sinensis, 1000 parts of radix scrophulariae, 200 parts of Radix Glycyrrhizae.Halite, fritillaria thunbergii, clam
Shell, prepared RADIX ET RHIZOMA RHEI, the compound of glauber-salt and liquorice, root of Chinese trichosanthes are ground into fine powder, and menthol is dissolved with ethanol in proper amount；It is Fructus Forsythiae, seaweed, radix ampelopsis, glutinous rehmannia, sweet
Grass, radix scrophulariae add water to cook secondary, and for the first time by 10 extraordinarily water of raw material weight, heating is boiled to boiling, is kept for 3 hours；Second
It is boiled to boiling, is kept for 2 hours by 8 extraordinarily water, heating of raw material weight.Extracting solution is filtered through 100 mesh filters, is placed in receiver
In, stand 1 hour.Selfheal adds water to cook secondary, and for the first time by 10 extraordinarily water of raw material weight, heating is boiled to boiling, keeps 3
Hour；Second of 8 extraordinarily water, heating for pressing raw material weight is boiled to boiling, is kept for 2 hours.Extracting solution is through 100 mesh filter mistakes
Filter, is placed in receiver, stands 1 hour.Merging more than decocting liquid, is condensed into thick paste.Radix Angelicae Sinensis is secondary with ethyl alcohol heating and refluxing extraction,
3 extraordinarily 95% ethyl alcohol of raw material weight are pressed for the first time, and heating and refluxing extraction is kept for 3 hours；Second of press raw material weight 3 times
Add 60% ethyl alcohol, heating and refluxing extraction is kept for 3 hours.Extracting solution is filtered through 100 mesh filters, is placed in receiver, stands 1
Hour.Campanulaceae, Fructus Aurantii are secondary with ethyl alcohol heating and refluxing extraction.3.5 extraordinarily 60% ethyl alcohol of raw material weight are pressed for the first time, are heated back
Stream extraction, is kept for 3 hours.Second of 2.5 extraordinarily 60% ethyl alcohol pressed with raw material weight, heating and refluxing extraction are kept for 2 hours,
Third time is kept for 1 hour by extraordinarily 60% ethyl alcohol of raw material weight 2, heating and refluxing extraction.Extracting solution is filtered through 100 mesh filters,
It is placed in receiver, stands 1 hour.Merging more than ethanol extract recycles ethyl alcohol, is condensed into thick paste.Above-mentioned condensed cream is closed
And add in powder and auxiliary material, the mixings such as halite, fritillaria thunbergii, clam shell, prepared RADIX ET RHIZOMA RHEI, the compound of glauber-salt and liquorice, root of Chinese trichosanthes and particle is made, it does
It is dry, menthol ethanol solution is added in, mixing obtains dried object A.
A kind of preparation of the Chinese medicine composition of softening and resolving hard mass, said preparation add in pharmacy with above-mentioned active constituents of medicine and can connect
Pharmaceutically acceptable dosage form is made in the auxiliary material received.Needed for the active constituent of the Chinese medicine composition preparation obtained using the present invention
During the various dosage forms of drug, it can be prepared according to the conventional production process of art of pharmacy.Such as by the active constituent with it is a kind of or
Variety carrier mixes, and corresponding dosage form is then made.
It is an advantage of the invention that：The present invention analyzes composition with theory of traditional Chinese medical science, according to the reason of each flavour of a drug ingredient
Change property and pharmacological action, study and obtained the preparation method of active constituent that is reasonable, stablizing.Technical side using the present invention
Case, stable and controllable for quality, curative effect significantly improves compared with existing commercial dosage forms, the pharmaceutical preparation of patient's taking dose reduction, tool
There is significant economic and social benefit.
Technical solution that the present invention will be described in detail by the following examples does not limit the practical range of the present invention with this.
Specific embodiment
Embodiment 1：Prepare Chinese medical extract
First, prescription：Selfheal 400g, fritillaria thunbergii 50g, seaweed 50g, radix ampelopsis 50g, root of Chinese trichosanthes 50g, Fructus Forsythiae 50g, prepared RADIX ET RHIZOMA RHEI
50g, compound of glauber-salt and liquorice 50g, clam shell (forge) 50g, halite 50g, Fructus Aurantii 50g, campanulaceae 50g, menthol 0.25g, glutinous rehmannia 50g, Radix Angelicae Sinensis
50g, radix scrophulariae 250g, Radix Glycyrrhizae 50g
2nd, preparation method：
Halite, fritillaria thunbergii, clam shell, prepared RADIX ET RHIZOMA RHEI, the compound of glauber-salt and liquorice, root of Chinese trichosanthes are ground into fine powder, and menthol ethanol in proper amount is molten
Solution；Fructus Forsythiae, seaweed, radix ampelopsis, glutinous rehmannia, Radix Glycyrrhizae, radix scrophulariae add water to cook secondary, and selfheal adds water to cook 5 hours, merge above decoct
Liquid is condensed into thick paste；95% ethyl alcohol of Radix Angelicae Sinensis and each heating and refluxing extraction of 60% ethyl alcohol are primary；Campanulaceae, 60% ethyl alcohol of Fructus Aurantii
Heating and refluxing extraction.Merging more than ethanol extract recycles ethyl alcohol, is condensed into thick paste.Above-mentioned condensed cream is merged, adds in smalt
Particle is made in the powder such as salt and auxiliary material, mixing, dry, adds in menthol ethanol solution, and mixing should go out granule number 853g.
Embodiment 2：Prepare Chinese medical extract
First, prescription：Selfheal 400kg, fritillaria thunbergii 50kg, seaweed 50kg, radix ampelopsis 50kg, root of Chinese trichosanthes 50kg, Fructus Forsythiae 50kg,
Prepared RADIX ET RHIZOMA RHEI 50kg, compound of glauber-salt and liquorice 50kg, clam shell (forge) 50kg, halite 50kg, Fructus Aurantii 50kg, campanulaceae 50kg, menthol 0.25kg,
Glutinous rehmannia 50kg, Radix Angelicae Sinensis 50kg, radix scrophulariae 250kg, Radix Glycyrrhizae 50kg.
2nd, preparation method：
Halite, fritillaria thunbergii, clam shell, prepared RADIX ET RHIZOMA RHEI, the compound of glauber-salt and liquorice, root of Chinese trichosanthes are ground into fine powder, and menthol ethanol in proper amount is molten
Solution；Fructus Forsythiae, seaweed, radix ampelopsis, glutinous rehmannia, Radix Glycyrrhizae, radix scrophulariae add water to cook secondary, and selfheal adds water to cook 5 hours, merge above decoct
Liquid is condensed into thick paste；95% ethyl alcohol of Radix Angelicae Sinensis and each heating and refluxing extraction of 60% ethyl alcohol are primary；Campanulaceae, 60% ethyl alcohol of Fructus Aurantii
Heating and refluxing extraction.Merging more than ethanol extract recycles ethyl alcohol, is condensed into thick paste.Above-mentioned condensed cream is merged, adds in smalt
Particle is made in the powder such as salt and auxiliary material, mixing, dry, adds in menthol ethanol solution, and mixing should go out granule number 853kg.
Embodiment 3：Prepare tablet
The active constituent 100g that embodiment 1 obtains, adds microcrystalline cellulose 40g, cross-linked pvp 7g, tabletting, obtains tablet, every
Weight 0.60g.
Embodiment 4：Prepare capsule
The active constituent 1000g that embodiment 2 obtains, adds starch 250g, and encapsulating capsule obtains capsule, every weight 0.50g.
Claims (8)
1. a kind of Chinese medicine composition of softening and resolving hard mass, active constituent are prepared from the following raw materials in parts by weight：Selfheal 1600
Part, 200 parts of fritillaria thunbergii, 200 parts of seaweed, 200 parts of radix ampelopsis, 200 parts of root of Chinese trichosanthes, 200 parts of Fructus Forsythiae, 200 parts of prepared RADIX ET RHIZOMA RHEI, the compound of glauber-salt and liquorice
200 parts, 200 parts of clam shell (forging), 200 parts of halite, 200 parts of Fructus Aurantii, 200 parts of campanulaceae, 1 part of menthol, 200 parts of glutinous rehmannia, Radix Angelicae Sinensis
200 parts, 1000 parts of radix scrophulariae, 200 parts of Radix Glycyrrhizae.
2. the Chinese medicine composition of a kind of softening and resolving hard mass according to claim 1, it is characterised in that the active constituent uses
Following methods are prepared：Halite, fritillaria thunbergii, clam shell, prepared RADIX ET RHIZOMA RHEI, the compound of glauber-salt and liquorice, root of Chinese trichosanthes are ground into fine powder, and menthol is used suitable
Measure ethyl alcohol dissolving；Fructus Forsythiae, seaweed, radix ampelopsis, glutinous rehmannia, Radix Glycyrrhizae, radix scrophulariae add water to cook secondary, and selfheal adds water to cook 5 hours, merge
More than decocting liquid, is condensed into thick paste；95% ethyl alcohol of Radix Angelicae Sinensis and each heating and refluxing extraction of 60% ethyl alcohol are primary；Campanulaceae, Fructus Aurantii are used
60% ethyl alcohol heating and refluxing extraction.Merging more than ethanol extract recycles ethyl alcohol, is condensed into thick paste.Above-mentioned condensed cream is merged,
It adds in powder and auxiliary material, the mixings such as halite and particle is made, it is dry, menthol ethanol solution is added in, mixing obtains dried object
A。
3. a kind of Chinese medicine composition of softening and resolving hard mass according to claim 2, it is characterised in that：Halite, fritillaria thunbergii, clam
Shell, prepared RADIX ET RHIZOMA RHEI, the compound of glauber-salt and liquorice, root of Chinese trichosanthes are ground into fine powder, and menthol is dissolved with ethanol in proper amount；It is Fructus Forsythiae, seaweed, radix ampelopsis, glutinous rehmannia, sweet
Grass, radix scrophulariae add water to cook secondary, and for the first time by 10 extraordinarily water of raw material weight, heating is boiled to boiling, is kept for 3 hours；Second
It is boiled to boiling, is kept for 2 hours by 8 extraordinarily water, heating of raw material weight.Extracting solution is filtered through 100 mesh filters, is placed in receiver
In, stand 1 hour.Selfheal adds water to cook secondary, and for the first time by 10 extraordinarily water of raw material weight, heating is boiled to boiling, keeps 3
Hour；Second of 8 extraordinarily water, heating for pressing raw material weight is boiled to boiling, is kept for 2 hours.Extracting solution is through 100 mesh filter mistakes
Filter, is placed in receiver, stands 1 hour.Merging more than decocting liquid, is condensed into thick paste.Radix Angelicae Sinensis is secondary with ethyl alcohol heating and refluxing extraction,
3 extraordinarily 95% ethyl alcohol of raw material weight are pressed for the first time, and heating and refluxing extraction is kept for 3 hours；Second of press raw material weight 3 times
Add 60% ethyl alcohol, heating and refluxing extraction is kept for 3 hours.Extracting solution is filtered through 100 mesh filters, is placed in receiver, stands 1
Hour.Campanulaceae, Fructus Aurantii are secondary with ethyl alcohol heating and refluxing extraction.3.5 extraordinarily 60% ethyl alcohol of raw material weight are pressed for the first time, are heated back
Stream extraction, is kept for 3 hours.Second of 2.5 extraordinarily 60% ethyl alcohol pressed with raw material weight, heating and refluxing extraction are kept for 2 hours,
Third time is kept for 1 hour by extraordinarily 60% ethyl alcohol of raw material weight 2, heating and refluxing extraction.Extracting solution is filtered through 100 mesh filters,
It is placed in receiver, stands 1 hour.Merging more than ethanol extract recycles ethyl alcohol, is condensed into thick paste.Above-mentioned condensed cream is closed
And add in powder and auxiliary material, the mixings such as halite, fritillaria thunbergii, clam shell, prepared RADIX ET RHIZOMA RHEI, the compound of glauber-salt and liquorice, root of Chinese trichosanthes and particle is made, it does
It is dry, menthol ethanol solution is added in, mixing obtains dried object A.
4. a kind of Chinese medicine composition of softening and resolving hard mass according to any one of claims 1 to 3, it is characterised in that：Institute
Belong to drug and also contain pharmaceutically acceptable auxiliary material.
5. a kind of Chinese medicine composition of softening and resolving hard mass according to claim 4, it is characterised in that：The pharmacy is subjected to
Auxiliary material to be selected from starch, microcrystalline cellulose, sucrose, Aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, methylol fine
The plain sodium of dimension, crosslinked polyvinylpyrrolidone, magnesium stearate, superfine silica gel powder, vitamin C, cysteine, citric acid and sodium sulfite
In any one or a few.
6. a kind of Chinese medicine composition of enriching yin and nourishing kidney according to claim 4, it is characterised in that：The Chinese medicine composition
Dosage form is peroral dosage form, including pill, tablet, capsule or oral liquid.
7. a kind of preparation method of the Chinese medicine composition of softening and resolving hard mass, it is characterised in that：1600 parts of selfheal, 200 parts of fritillaria thunbergii,
200 parts of seaweed, 200 parts of radix ampelopsis, 200 parts of root of Chinese trichosanthes, 200 parts of Fructus Forsythiae, 200 parts of prepared RADIX ET RHIZOMA RHEI, 200 parts of the compound of glauber-salt and liquorice, clam shell (forging) 200
Part, 200 parts of halite, 200 parts of Fructus Aurantii, 200 parts of campanulaceae, 1 part of menthol, 200 parts of glutinous rehmannia, 200 parts of Radix Angelicae Sinensis, 1000 parts of radix scrophulariae,
200 parts of Radix Glycyrrhizae.Halite, fritillaria thunbergii, clam shell, prepared RADIX ET RHIZOMA RHEI, the compound of glauber-salt and liquorice, root of Chinese trichosanthes are ground into fine powder, menthol ethanol in proper amount
Dissolving；Fructus Forsythiae, seaweed, radix ampelopsis, glutinous rehmannia, Radix Glycyrrhizae, radix scrophulariae add water to cook secondary, and selfheal adds water to cook 5 hours, merge above decoct
Liquid is condensed into thick paste；95% ethyl alcohol of Radix Angelicae Sinensis and each heating and refluxing extraction of 60% ethyl alcohol are primary；Campanulaceae, 60% ethyl alcohol of Fructus Aurantii
Heating and refluxing extraction.Merging more than ethanol extract recycles ethyl alcohol, is condensed into thick paste.Above-mentioned condensed cream is merged, adds in smalt
Particle is made in the powder such as salt and auxiliary material, mixing, dry, adds in menthol ethanol solution, and mixing obtains dried object A.
8. a kind of Chinese medicine composition of softening and resolving hard mass according to claim 1 according to claim 7, feature exist
In：1600 parts of selfheal, 200 parts of fritillaria thunbergii, 200 parts of seaweed, 200 parts of radix ampelopsis, 200 parts of root of Chinese trichosanthes, 200 parts of Fructus Forsythiae, prepared RADIX ET RHIZOMA RHEI
200 parts, 200 parts of the compound of glauber-salt and liquorice, 200 parts of clam shell (forging), 200 parts of halite, 200 parts of Fructus Aurantii, 200 parts of campanulaceae, 1 part of menthol,
200 parts yellow, 200 parts of Radix Angelicae Sinensis, 1000 parts of radix scrophulariae, 200 parts of Radix Glycyrrhizae.Halite, fritillaria thunbergii, clam shell, prepared RADIX ET RHIZOMA RHEI, the compound of glauber-salt and liquorice, smallpox
Powder is ground into fine powder, and menthol is dissolved with ethanol in proper amount；Fructus Forsythiae, seaweed, radix ampelopsis, glutinous rehmannia, Radix Glycyrrhizae, radix scrophulariae add water to cook it is secondary,
It is boiled to boiling, is kept for 3 hours by 10 extraordinarily water, heating of raw material weight for the first time；Second by raw material weight 8 extraordinarily water,
Heating is boiled to boiling, is kept for 2 hours.Extracting solution is filtered through 100 mesh filters, is placed in receiver, stands 1 hour.Selfheal
Add water to cook secondary, for the first time by 10 extraordinarily water of raw material weight, heating is boiled to boiling, is kept for 3 hours；Second by raw material weight
The extraordinarily water of the 8 of amount, heating are boiled to boiling, are kept for 2 hours.Extracting solution is filtered through 100 mesh filters, is placed in receiver, stands 1
Hour.Merging more than decocting liquid, is condensed into thick paste.Radix Angelicae Sinensis is secondary with ethyl alcohol heating and refluxing extraction, for the first time by 3 times of raw material weight
Add 95% ethyl alcohol, heating and refluxing extraction is kept for 3 hours；Second of 3 extraordinarily 60% ethyl alcohol for pressing raw material weight, is heated to reflux carrying
It takes, is kept for 3 hours.Extracting solution is filtered through 100 mesh filters, is placed in receiver, stands 1 hour.Campanulaceae, Fructus Aurantii are added with ethyl alcohol
Circumfluence distillation is secondary.3.5 extraordinarily 60% ethyl alcohol of raw material weight are pressed for the first time, and heating and refluxing extraction is kept for 3 hours.Second
Secondary 2.5 extraordinarily 60% ethyl alcohol pressed with raw material weight, heating and refluxing extraction, holding 2 hours, by raw material weight 2 extraordinarily for the third time
60% ethyl alcohol, heating and refluxing extraction are kept for 1 hour.Extracting solution is filtered through 100 mesh filters, is placed in receiver, and it is small to stand 1
When.Merging more than ethanol extract recycles ethyl alcohol, is condensed into thick paste.Above-mentioned condensed cream is merged, add in halite, fritillaria thunbergii,
Particle is made in powder and the auxiliary materials such as clam shell, prepared RADIX ET RHIZOMA RHEI, the compound of glauber-salt and liquorice, root of Chinese trichosanthes, mixing, dry, adds in menthol ethanol solution,
Mixing obtains dried object A.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109893593A (en) * | 2017-12-07 | 2019-06-18 | 天津中新药业集团股份有限公司隆顺榕制药厂 | A kind of Chinese medicine composition and preparation method thereof for treating tumour |
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Addressee: Longshunrong Pharmaceutical Factory, Tianjin, Zhongxin, Pharmaceutical Group Co. Document name: Notification of before Expiration of Request of Examination as to Substance |
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