CN108125877A - A kind of Chinese medicine composition and preparation method thereof and purposes - Google Patents
A kind of Chinese medicine composition and preparation method thereof and purposes Download PDFInfo
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- CN108125877A CN108125877A CN201711477177.0A CN201711477177A CN108125877A CN 108125877 A CN108125877 A CN 108125877A CN 201711477177 A CN201711477177 A CN 201711477177A CN 108125877 A CN108125877 A CN 108125877A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The present invention discloses a kind of Chinese medicine composition and preparation method thereof and purposes.The Chinese medicine composition includes：16 20 parts by weight of fennel seeds seed,18 24 parts by weight of perilla seed,28 34 parts by weight of sweet basil leaf,24 32 parts by weight of Cajeputtree Leaf,15 25 parts by weight of mulberry leaf,10 18 parts by weight of felwort rhizome,14 19 parts by weight of lotus leaf,10 18 parts by weight of honeysuckle,15 23 parts by weight of Chinese violet complete stool,13 19 parts by weight of 11 17 parts by weight of kuh-seng complete stool and lilac,Rich in a variety of active constituents with bacteriostasis efficacy,With broad-spectrum antibacterial effect and anti-oxidation function,Cosmetic Manufacture or use can effectively be inhibited in the process by staphylococcus aureus,Escherichia coli,Pseudomonas aeruginosa,The strain pollutions such as salmonella,Cosmetics can be avoided to contact with air simultaneously to aoxidize,Moisturizing can be played by being added in cosmetics,Whitening,Anti-acne,Anti-inflammatory,Anti-aging function.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition and preparation method thereof and purposes.
Background technology
China uses big country for cosmetics, and the dosage of cosmetics increases year by year.To meet effect demand, in cosmetics often
It, can be dirty by bacterium or fungi when cosmetics are contacted with air, user during production or use containing multiple nutritional components
Dye, causes cosmetics from deterioration even to generate the substance being harmful to skin.For cosmetics is avoided to be contaminated by bacterial in use,
Extend cosmetics service life, in the prior art mostly by add chemical preservative achieve the effect that it is antibacterial.But Long Term Contact
Chemical preservative can cause skin certain damage, and epidermis is thinning, and easily by environmental stimuli, phylactic power defensive power declines, and causes skin
Rubescent, the problems such as itching, is sensitive is generated, skin is made to follow the string gradually, easily generates relaxation, microgroove.Such as P-hydroxybenzoic acid
Ester type compound is common preservative in cosmetics, and some researches show that parabens substance can cause contact
Dermatitis.
With the raising of people's level of consumption and the change of the consumption consciousness, requirement of the people for skin care item is also all the more tight
Lattice more advocate the ingredient that natural component substitutes traditional chemical synthesis.Have there are many containing in natural plants particularly Chinese herbal medicine
Ingredient is imitated, China has long history for the application of Chinese herbal medicine and active ingredient extraction, and technology is more perfect, if can will extract
The effect of active ingredient gone out is applied to play its uniqueness in the production of skin care item, this will be as those skilled in the art's future
Research and development focus.
Invention content
Therefore, the technical problem to be solved in the present invention is cosmetics of the prior art is overcome because of addition chemical synthesis to prevent
Rotten agent and lead to the defects of skin problem occur, so as to provide a kind of Chinese medicine composition that alternative chemical preservative uses and its
Preparation method and purposes.
For this purpose, the present invention provides a kind of Chinese medicine composition, include the bulk pharmaceutical chemicals of following parts by weight：
Fennel seeds seed 16-20 parts by weight, perilla seed 18-24 parts by weight, sweet basil leaf 28-34 parts by weight, Cajeputtree Leaf 24-32
Parts by weight, mulberry leaf 15-25 parts by weight, felwort rhizome 10-18 parts by weight, lotus leaf 14-19 parts by weight, honeysuckle 10-18 weight
Part, Chinese violet complete stool 15-23 parts by weight, kuh-seng complete stool 11-17 parts by weight and lilac 13-19 parts by weight.
The Chinese medicine composition includes the bulk pharmaceutical chemicals of following parts by weight：
18 parts by weight of fennel seeds seed, 21 parts by weight of perilla seed, 31 parts by weight of sweet basil leaf, 28 parts by weight of Cajeputtree Leaf, mulberry leaf
20 parts by weight, 14 parts by weight of felwort rhizome, 16 parts by weight of lotus leaf, 14 parts by weight of honeysuckle, 19 parts by weight of Chinese violet complete stool,
16 parts by weight of 15 parts by weight of kuh-seng complete stool and lilac；Or
16 parts by weight of fennel seeds seed, 24 parts by weight of perilla seed, 34 parts by weight of sweet basil leaf, 32 parts by weight of Cajeputtree Leaf, mulberry leaf
25 parts by weight, 18 parts by weight of felwort rhizome, 19 parts by weight of lotus leaf, 18 parts by weight of honeysuckle, 23 parts by weight of Chinese violet complete stool,
19 parts by weight of 17 parts by weight of kuh-seng complete stool and lilac；Or
20 parts by weight of fennel seeds seed, 18 parts by weight of perilla seed, 28 parts by weight of sweet basil leaf, 24 parts by weight of Cajeputtree Leaf, mulberry leaf
15 parts by weight, 10 parts by weight of felwort rhizome, 14 parts by weight of lotus leaf, 10 parts by weight of honeysuckle, 15 parts by weight of Chinese violet complete stool,
13 parts by weight of 11 parts by weight of kuh-seng complete stool and lilac；Or
19 parts by weight of fennel seeds seed, 22 parts by weight of perilla seed, 30 parts by weight of sweet basil leaf, 31 parts by weight of Cajeputtree Leaf, mulberry leaf
17 parts by weight, 16 parts by weight of felwort rhizome, 18 parts by weight of lotus leaf, 16 parts by weight of honeysuckle, 17 parts by weight of Chinese violet complete stool,
15 parts by weight of 13 parts by weight of kuh-seng complete stool and lilac.
The Chinese medicine composition, further includes：Leaf of bamboo 18-25 parts by weight, Pogostemon cablin cauline leaf 14-20 parts by weight pass through leaf company
Stick up complete stool 6-12 parts by weight, camellia seed 5-10 parts by weight, Chinese torreya aril 4-8 parts by weight, rhodiola root rhizome 12-20 parts by weight and
Stem of Dendrobium 7-11 parts by weight.
The Chinese medicine composition, 22 parts by weight of the leaf of bamboo, 17 parts by weight of Pogostemon cablin cauline leaf, 9 parts by weight of hypericum perforatum complete stool,
7 parts by weight of camellia seed, 9 parts by weight of 6 parts by weight of Chinese torreya aril, 16 parts by weight of rhodiola root rhizome and stem of Dendrobium；Or
18 parts by weight of the leaf of bamboo, 20 parts by weight of Pogostemon cablin cauline leaf, 12 parts by weight of hypericum perforatum complete stool, 10 parts by weight of camellia seed,
11 parts by weight of 8 parts by weight of Chinese torreya aril, 20 parts by weight of rhodiola root rhizome and stem of Dendrobium；Or
25 parts by weight of the leaf of bamboo, 14 parts by weight of Pogostemon cablin cauline leaf, 6 parts by weight of hypericum perforatum complete stool, 5 parts by weight of camellia seed, perfume (or spice)
7 parts by weight of 4 parts by weight of Chinese torreya aril, 12 parts by weight of rhodiola root rhizome and stem of Dendrobium；Or
20 parts by weight of the leaf of bamboo, 19 parts by weight of Pogostemon cablin cauline leaf, 10 parts by weight of hypericum perforatum complete stool, 8 parts by weight of camellia seed, perfume (or spice)
8 parts by weight of 5 parts by weight of Chinese torreya aril, 15 parts by weight of rhodiola root rhizome and stem of Dendrobium.
The method of the Chinese medicine composition, includes the following steps：
(1) fennel seeds seed, perilla seed, honeysuckle and lilac are mixed, after crushing, adds in 10-30 times of bulk pharmaceutical chemicals powder
The ethanol solution A of amount, ultrasonic extraction then remove solvent, obtain extracting solution A；
The concentration of volume percent of the ethanol solution A is 60-70%；
(2) after mulberry leaf and Chinese violet complete stool being mixed, crushed, bulk pharmaceutical chemicals 5-10 times of ethanol solution B measured of powder is added in,
Ultrasonic extraction then removes solvent, obtains extracting solution B；
The concentration of volume percent of the ethanol solution B is 75-95%；
(3) sweet basil leaf, felwort rhizome and Cajeputtree Leaf are mixed, after crushing, using supercritical CO2Extraction, is carried
Take liquid C；
(4) after lotus leaf and kuh-seng complete stool being mixed, crushed, using supercritical CO2Extraction, obtains extracting solution D；
(5) the extracting solution A, extracting solution B, extracting solution C, extracting solution D are uniformly mixed to get the Chinese medicine composition.
The method of the Chinese medicine composition, includes the following steps：
(1) fennel seeds seed, perilla seed, honeysuckle, lilac and camellia seed are mixed, after crushing, adds in bulk pharmaceutical chemicals powder
The 10-30 times of ethanol solution A measured, ultrasonic extraction then remove solvent, obtain extracting solution A '；
The concentration of volume percent of the ethanol solution A is 60-70%；
(2) mulberry leaf, Chinese violet complete stool, the leaf of bamboo and hypericum perforatum complete stool are mixed, after crushing, adds in bulk pharmaceutical chemicals powder 5-
The ethanol solution B of 10 times of amounts, ultrasonic extraction then remove solvent, obtain extracting solution B '；
The concentration of volume percent of the ethanol solution B is 75-95%；
(3) by sweet basil leaf, Cajeputtree Leaf, felwort rhizome, Pogostemon cablin cauline leaf, Chinese torreya aril, rhodiola root rhizome and stone
After the mixing of dry measure used in former times stem, crushing, using supercritical CO2Extraction, obtains extracting solution C '；
(4) after lotus leaf and kuh-seng complete stool being mixed, crushed, using supercritical CO2Extraction, obtains extracting solution D '；
(5) the extracting solution A ', extracting solution B ', extracting solution C ', extracting solution D ' are uniformly mixed to get the Chinese traditional medicine composition
Object.
The preparation method, the middle ultrasonic wave extraction 4-10min using 0.5-2MHz of step (1)；And/or step (2)
The middle ultrasonic wave extraction 3-6min using 0.2-1MHz.
The preparation method, CO in the step (3)2Flow is 5-10kg/h, pressure 20-30MPa, extraction time
For 1-2h；And/or CO in the step (4)2Flow is 8-12kg/h, pressure 12-18MPa, extraction time 0.5-1.5h.
The present invention also provides above-mentioned Chinese medicine composition in protection cosmetics from the purposes in germ contamination.
The purposes, the additive amount of the Chinese medicine composition are the 0.01-0.5wt% of the cosmetics gross mass.
Technical solution of the present invention has the following advantages that：
1st, Chinese medicine composition provided by the invention, including the following raw material medicine：Fennel seeds seed 16-20 parts by weight, perilla seed 18-
24 parts by weight, sweet basil leaf 28-34 parts by weight, Cajeputtree Leaf 24-32 parts by weight, mulberry leaf 15-25 parts by weight, felwort rhizome 10-
18 parts by weight, lotus leaf 14-19 parts by weight, honeysuckle 10-18 parts by weight, Chinese violet complete stool 15-23 parts by weight, kuh-seng complete stool
11-17 parts by weight and lilac 13-19 parts by weight.Chinese medicine composition provided by the invention is rich in a variety of work with bacteriostasis efficacy
Property ingredient, there is broad-spectrum antibacterial effect and anti-oxidation function, can effectively inhibit golden yellow during Cosmetic Manufacture or use
The strain pollutions such as staphylococcus, Escherichia coli, Pseudomonas aeruginosa, salmonella, Bacillus cereus, aerobacteria, Serratieae,
Cosmetics can be avoided to contact with air aoxidize simultaneously, be added in cosmetics can play moisturizing, anti-acne, whitening, anti-inflammatory,
Anti-aging function.
2nd, Chinese medicine composition provided by the invention, further includes：Leaf of bamboo 18-25 parts by weight, Pogostemon cablin cauline leaf 14-20 weight
Part, hypericum perforatum complete stool 6-12 parts by weight, camellia seed 5-10 parts by weight, Chinese torreya aril 4-8 parts by weight, rhodiola root rhizome 12-
20 parts by weight and stem of Dendrobium 7-11 parts by weight, rich in flavonoids, glycoside, polysaccharide and polyphenol active ingredient, have it is antibacterial, disappear
The effects that scorching.The growth of bacterium and fungi in cosmetics can effectively be inhibited by being added in cosmetics, while can be played moisturizing, be resisted
The effect of acne, whitening, anti-inflammatory.
3rd, the preparation method of Chinese medicine composition provided by the invention, includes the following steps：(1) by fennel seeds seed, perilla seed,
Honeysuckle and lilac mixing after crushing, add in bulk pharmaceutical chemicals 10-30 times of ethanol solution A measured of powder, ultrasonic extraction is then gone
Except solvent, extracting solution A is obtained；The concentration of volume percent of ethanol solution A is 60-70%；(2) by mulberry leaf and Chinese violet complete stool
Mixing after crushing, adds in bulk pharmaceutical chemicals 5-10 times of ethanol solution B measured of powder, and ultrasonic extraction then removes solvent, extracted
Liquid B；The concentration of volume percent of ethanol solution B is 75-95%；(3) mix sweet basil leaf, felwort rhizome and Cajeputtree Leaf,
After crushing, using supercritical CO2Extraction, obtains extracting solution C；(4) after lotus leaf and kuh-seng complete stool being mixed, crushed, faced using super
Boundary CO2Extraction, obtains extracting solution D；(5) by extracting solution A, extracting solution B, extracting solution C, extracting solution D be uniformly mixed to get.This hair
It is bright to be extracted by the way that bulk pharmaceutical chemicals are carried out with mixing in batches, so as to generate synergistic effect between different material medicine, improve in bulk pharmaceutical chemicals
The recovery rate of active constituent, so as to promote the bacteriostatic activity of Chinese medicine composition of the present invention and antioxidant activity.
4th, the preparation method of Chinese medicine composition provided by the invention, ultrasonic wave can break up cell wall, when effectively shortening extraction
Between, the limitation of extraction efficiency, not receptor 1 activity component molecules size is improved, is had a wide range of application, DNA purity is high.
5th, the preparation method of Chinese medicine composition provided by the invention, supercritical CO2Extraction conditions is mild, and active ingredient is broken
It is bad small, use CO2Make extractant, it is stable, nontoxic, the oxidation of extract can be avoided, DNA purity is high.
6th, Chinese medicine composition provided by the invention, has broad-spectrum antibacterial effect, and alternative chemical preservative is added to makeup
In product, antibacterial oxidation resistant effect can be played and stimulate skin, may also function as certain auxiliary skin effect.
Specific embodiment
Illustrate embodiments of the present invention below by way of specific embodiment, unless otherwise stated, disclosed in this invention
Experimental method using the art routine techniques, used reagent and raw material can be bought by market in embodiment.
Embodiment 1
A kind of Chinese medicine composition is present embodiments provided, including the following raw material medicine：Fennel seeds seed 18g, perilla seed 21g, sieve
Strangle leaf 31g, Cajeputtree Leaf 28g, mulberry leaf 20g, felwort rhizome 14g, lotus leaf 16g, honeysuckle 14g, Chinese violet complete stool 19g,
Kuh-seng complete stool 15g and lilac 16g.
The present embodiment additionally provides the preparation method of above-mentioned Chinese medicine composition, includes the following steps：
(1) fennel seeds seed, perilla seed, honeysuckle and lilac are mixed, after crushing, adds in 20 times of amounts of bulk pharmaceutical chemicals powder
Concentration of volume percent is 65% ethanol solution, using the ultrasonic wave extraction 7min of 1.5MHz, then removes solvent, is carried
Take liquid A；
(2) after mulberry leaf and Chinese violet complete stool being mixed, crushed, the percent by volume for adding in 8 times of amounts of bulk pharmaceutical chemicals powder is dense
The ethanol solution for 85% is spent, using the ultrasonic wave extraction 5min of 0.6MHz, solvent is then removed, obtains extracting solution B；
(3) sweet basil leaf, felwort rhizome and Cajeputtree Leaf are mixed, after crushing, using supercritical CO2Extraction, CO2Flow
Extracting solution C is obtained for 8kg/h, pressure 25MPa, extraction time 1.5h；
(4) after lotus leaf and kuh-seng complete stool being mixed, crushed, using supercritical CO2Extraction, CO2Flow is 10kg/h, pressure
Extracting solution D is obtained for 15MPa, extraction time 1h；
(5) extracting solution A, extracting solution B, extracting solution C, extracting solution D are uniformly mixed to get the Chinese medicine composition.
Embodiment 2
A kind of Chinese medicine composition is present embodiments provided, including the following raw material medicine：Fennel seeds seed 16g, perilla seed 24g, sieve
Strangle leaf 34g, Cajeputtree Leaf 32g, mulberry leaf 25g, felwort rhizome 18g, lotus leaf 19g, honeysuckle 18g, Chinese violet complete stool 23g,
Kuh-seng complete stool 17g and lilac 19g.
The present embodiment additionally provides the preparation method of above-mentioned Chinese medicine composition, includes the following steps：
(1) fennel seeds seed, perilla seed, honeysuckle and lilac are mixed, after crushing, adds in 10 times of amounts of bulk pharmaceutical chemicals powder
Concentration of volume percent is 70% ethanol solution, using the ultrasonic wave extraction 4min of 2MHz, then removes solvent, is extracted
Liquid A；
(2) after mulberry leaf and Chinese violet complete stool being mixed, crushed, the percent by volume for adding in 10 times of amounts of bulk pharmaceutical chemicals powder is dense
The ethanol solution for 75% is spent, using the ultrasonic wave extraction 6min of 0.2MHz, solvent is then removed, obtains extracting solution B；
(3) sweet basil leaf, felwort rhizome and Cajeputtree Leaf are mixed, after crushing, using supercritical CO2Extraction, CO2Flow
Extracting solution C is obtained for 10kg/h, pressure 30MPa, extraction time 1h；
(4) after lotus leaf and kuh-seng complete stool being mixed, crushed, using supercritical CO2Extraction, CO2Flow is 8kg/h, and pressure is
12MPa, extraction time 1.5h obtain extracting solution D；
(5) extracting solution A, extracting solution B, extracting solution C, extracting solution D are uniformly mixed to get the Chinese medicine composition.
Embodiment 3
A kind of Chinese medicine composition is present embodiments provided, including the following raw material medicine：Fennel seeds seed 20g, perilla seed 18g, sieve
Strangle leaf 28g, Cajeputtree Leaf 24g, mulberry leaf 15g, felwort rhizome 10g, lotus leaf 14g, honeysuckle 10g, Chinese violet complete stool 15g,
Kuh-seng complete stool 11g and lilac 13g.
The present embodiment additionally provides the preparation method of above-mentioned Chinese medicine composition, includes the following steps：
(1) fennel seeds seed, perilla seed, honeysuckle and lilac are mixed, after crushing, adds in 30 times of amounts of bulk pharmaceutical chemicals powder
Concentration of volume percent is 60% ethanol solution, using the ultrasonic wave extraction 10min of 0.5MHz, then removes solvent, obtains
Extracting solution A；
(2) after mulberry leaf and Chinese violet complete stool being mixed, crushed, the percent by volume for adding in 5 times of amounts of bulk pharmaceutical chemicals powder is dense
The ethanol solution for 95% is spent, using the ultrasonic wave extraction 3min of 1MHz, solvent is then removed, obtains extracting solution B；
(3) sweet basil leaf, felwort rhizome and Cajeputtree Leaf are mixed, after crushing, using supercritical CO2Extraction, CO2Flow
Extracting solution C is obtained for 5kg/h, pressure 20MPa, extraction time 2h；
(4) after lotus leaf and kuh-seng complete stool being mixed, crushed, using supercritical CO2Extraction, CO2Flow is 12kg/h, pressure
Extracting solution D is obtained for 18MPa, extraction time 0.5h；
(5) extracting solution A, extracting solution B, extracting solution C, extracting solution D are uniformly mixed to get the Chinese medicine composition.
Embodiment 4
A kind of Chinese medicine composition is present embodiments provided, including the following raw material medicine：Fennel seeds seed 19g, perilla seed 22g, sieve
Strangle leaf 30g, Cajeputtree Leaf 31g, mulberry leaf 17g, felwort rhizome 16g, lotus leaf 18g, honeysuckle 16g, Chinese violet complete stool 17g,
Kuh-seng complete stool 13g and lilac 15g.
The present embodiment additionally provides the preparation method of above-mentioned Chinese medicine composition, includes the following steps：
(1) fennel seeds seed, perilla seed, honeysuckle and lilac are mixed, after crushing, adds in 25 times of amounts of bulk pharmaceutical chemicals powder
Concentration of volume percent is 62% ethanol solution, using the ultrasonic wave extraction 6min of 1MHz, then removes solvent, is extracted
Liquid A；
(2) after mulberry leaf and Chinese violet complete stool being mixed, crushed, the percent by volume for adding in 6 times of amounts of bulk pharmaceutical chemicals powder is dense
The ethanol solution for 90% is spent, using the ultrasonic wave extraction 4min of 0.8MHz, solvent is then removed, obtains extracting solution B；
(3) sweet basil leaf, felwort rhizome and Cajeputtree Leaf are mixed, after crushing, using supercritical CO2Extraction, CO2Flow
Extracting solution C is obtained for 6kg/h, pressure 28MPa, extraction time 1.3h；
(4) after lotus leaf and kuh-seng complete stool being mixed, crushed, using supercritical CO2Extraction, CO2Flow is 9kg/h, and pressure is
16MPa, extraction time 1.2h obtain extracting solution D；
(5) extracting solution A, extracting solution B, extracting solution C, extracting solution D are uniformly mixed to get the Chinese medicine composition.
Embodiment 5
A kind of Chinese medicine composition is present embodiments provided, including following component：Fennel seeds seed 18g, perilla seed 21g, sweet basil
Leaf 31g, Cajeputtree Leaf 28g, mulberry leaf 20g, felwort rhizome 14g, lotus leaf 16g, honeysuckle 14g, Chinese violet complete stool 19g, hardship
Join complete stool 15g, lilac 16g, leaf of bamboo 22g, Pogostemon cablin cauline leaf 17g, hypericum perforatum complete stool 9g, camellia seed 7g, Chinese torreya aril
6g, rhodiola root rhizome 16g and stem of Dendrobium 9g.
The present embodiment additionally provides the preparation method of above-mentioned Chinese medicine composition, includes the following steps：
(1) by after fennel seeds seed, perilla seed, honeysuckle, lilac and camellia seed, the body of 20 times of amounts of bulk pharmaceutical chemicals powder is added in
The ethanol solution that product percent concentration is 65%, using the ultrasonic wave extraction 7min of 1.5MHz, then removes solvent, is extracted
Liquid A '；
(2) mulberry leaf, Chinese violet complete stool, the leaf of bamboo and hypericum perforatum complete stool complete stool are mixed, after crushing, adds in raw material medicinal powder
The ethanol solution that the concentration of volume percent of the 8 times of amounts in end is 85%, using the ultrasonic wave extraction 5min of 0.6MHz, then removes molten
Agent obtains extracting solution B '；
(3) will by sweet basil leaf, Cajeputtree Leaf, felwort rhizome, Pogostemon cablin cauline leaf, Chinese torreya aril, rhodiola root rhizome and
After stem of Dendrobium mixing, crushing, using supercritical CO2Extraction, CO2Flow is 8kg/h, pressure 25MPa, extraction time 1.5h,
Obtain extracting solution C '；
(4) after lotus leaf and kuh-seng complete stool being mixed, crushed, using supercritical CO2Extraction, CO2Flow is 10kg/h, pressure
Extracting solution D ' is obtained for 15MPa, extraction time 1h；
(5) extracting solution A ', extracting solution B ', extracting solution C ', extracting solution D ' are uniformly mixed to get the Chinese medicine composition.
Embodiment 6
A kind of Chinese medicine composition is present embodiments provided, including the following raw material medicine：Fennel seeds seed 16g, perilla seed 24g, sieve
Strangle leaf 34g, Cajeputtree Leaf 32g, mulberry leaf 25g, felwort rhizome 18g, lotus leaf 19g, honeysuckle 18g, Chinese violet complete stool 23g,
Kuh-seng complete stool 17g, lilac 19g, leaf of bamboo 18g, Pogostemon cablin cauline leaf 20g, hypericum perforatum complete stool 12g, camellia seed 10g, Chinese torreya are false
Kind skin 8g, rhodiola root rhizome 20g and stem of Dendrobium 11g.
The present embodiment additionally provides the preparation method of above-mentioned Chinese medicine composition, includes the following steps：
(1) fennel seeds seed, perilla seed, honeysuckle, lilac and camellia seed are mixed, after crushing, adds in bulk pharmaceutical chemicals powder
The concentration of volume percent of 10 times of amounts is 70% ethanol solution, using the ultrasonic wave extraction 4min of 2MHz, then removes solvent,
Obtain extracting solution A '；
(2) mulberry leaf, Chinese violet complete stool, the leaf of bamboo and hypericum perforatum complete stool are mixed, after crushing, adds in bulk pharmaceutical chemicals powder 10
The concentration of volume percent of amount is 75% ethanol solution again, using the ultrasonic wave extraction 6min of 0.2MHz, then removes solvent,
Obtain extracting solution B '；
(3) by sweet basil leaf, Cajeputtree Leaf, felwort rhizome, Pogostemon cablin cauline leaf, Chinese torreya aril, rhodiola root rhizome and stone
After the mixing of dry measure used in former times stem, crushing, using supercritical CO2Extraction, CO2Flow is 10kg/h, pressure 30MPa, extraction time 0.5h,
Obtain extracting solution C '；
(4) after lotus leaf and kuh-seng complete stool being mixed, crushed, using supercritical CO2Extraction, CO2Flow is 8kg/h, and pressure is
12MPa, extraction time 1.5h obtain extracting solution D '；
(5) extracting solution A ', extracting solution B ', extracting solution C ', extracting solution D ' are uniformly mixed to get the Chinese medicine composition.
Embodiment 7
A kind of Chinese medicine composition is present embodiments provided, including the following raw material medicine：Fennel seeds seed 20g, perilla seed 18g, sieve
Strangle leaf 28g, Cajeputtree Leaf 24g, mulberry leaf 15g, felwort rhizome 10g, lotus leaf 14g, honeysuckle 10g, Chinese violet complete stool 15g,
False kind of kuh-seng complete stool 11g, lilac 13g, leaf of bamboo 25g, Pogostemon cablin cauline leaf 14g, hypericum perforatum complete stool 6g, camellia seed 5g, Chinese torreya
Skin 4g, rhodiola root rhizome 12g and stem of Dendrobium 7g.
The present embodiment additionally provides the preparation method of above-mentioned Chinese medicine composition, includes the following steps：
(1) fennel seeds seed, perilla seed, honeysuckle, lilac and camellia seed are mixed, after crushing, adds in bulk pharmaceutical chemicals powder
The concentration of volume percent of 30 times of amounts is 60% ethanol solution, using the ultrasonic wave extraction 10min of 0.5MHz, is then removed molten
Agent obtains extracting solution A '；
(2) mulberry leaf, Chinese violet complete stool, the leaf of bamboo and hypericum perforatum complete stool are mixed, after crushing, adds in bulk pharmaceutical chemicals powder 5
The concentration of volume percent of amount is 95% ethanol solution again, using the ultrasonic wave extraction 3min of 1MHz, then removes solvent, obtains
To extracting solution B '；
(3) by sweet basil leaf, Cajeputtree Leaf, felwort rhizome, Pogostemon cablin cauline leaf, Chinese torreya aril, rhodiola root rhizome and stone
After the mixing of dry measure used in former times stem, crushing, using supercritical CO2Extraction, CO2Flow is 5kg/h, and pressure 20MPa, extraction time 2h are obtained
Extracting solution C '；
(4) after lotus leaf and kuh-seng complete stool being mixed, crushed, using supercritical CO2Extraction, CO2Flow is 12kg/h, pressure
Extracting solution D ' is obtained for 18MPa, extraction time 1h；
(5) extracting solution A ', extracting solution B ', extracting solution C ', extracting solution D ' are uniformly mixed to get the Chinese medicine composition.
Embodiment 8
A kind of Chinese medicine composition is present embodiments provided, including the following raw material medicine：Fennel seeds seed 19g, perilla seed 22g, sieve
Strangle leaf 30g, Cajeputtree Leaf 31g, mulberry leaf 17g, felwort rhizome 16g, lotus leaf 18g, honeysuckle 16g, Chinese violet complete stool 17g,
False kind of kuh-seng complete stool 13g, lilac 15g, leaf of bamboo 20g, Pogostemon cablin cauline leaf 19g, hypericum perforatum complete stool 10g, camellia seed 8g, Chinese torreya
Skin 5g, rhodiola root rhizome 15g and stem of Dendrobium 8g.
The present embodiment additionally provides the preparation method of above-mentioned Chinese medicine composition, includes the following steps：
(1) fennel seeds seed, perilla seed, honeysuckle, lilac and camellia seed are mixed, after crushing, adds in bulk pharmaceutical chemicals powder
The concentration of volume percent of 15 times of amounts is 68% ethanol solution, using the ultrasonic wave extraction 9min of 1.2MHz, is then removed molten
Agent obtains extracting solution A '；
(2) mulberry leaf, Chinese violet complete stool, the leaf of bamboo and hypericum perforatum complete stool are mixed, after crushing, adds in bulk pharmaceutical chemicals powder 7
The concentration of volume percent of amount is 80% ethanol solution again, using the ultrasonic wave extraction 5min of 0.9MHz, then removes solvent,
Obtain extracting solution B '；
(3) by sweet basil leaf, Cajeputtree Leaf, felwort rhizome, Pogostemon cablin cauline leaf, Chinese torreya aril, rhodiola root rhizome and stone
After the mixing of dry measure used in former times stem, crushing, using supercritical CO2Extraction, CO2Flow is 9kg/h, and pressure 24MPa, extraction time 1.8h are obtained
To extracting solution C '；
(4) after lotus leaf and kuh-seng complete stool being mixed, crushed, using supercritical CO2Extraction, CO2Flow is 11kg/h, pressure
Extracting solution D ' is obtained for 14MPa, extraction time 0.7h；
(5) extracting solution A ', extracting solution B ', extracting solution C ', extracting solution D ' are uniformly mixed to get the Chinese medicine composition.
Comparative example 1
This comparative example provides a kind of preparation method of active Chinese drug component compositions：
(1) after crushing fennel seeds seed 18g, perilla seed 21g, honeysuckle 14g and lilac 16g respectively, each raw material is added in
The ethanol solution that the concentration of volume percent of the 20 times of amounts in medicinal powder end are 65%, using the ultrasonic wave extraction 7min of 1.5MHz, then
Solvent is removed, respectively obtains the extracting solution of each bulk pharmaceutical chemicals；
(2) after crushing mulberry leaf 20g and Chinese violet complete stool 19g respectively, the volume hundred of each 8 times of amounts of bulk pharmaceutical chemicals powder is added in
The ethanol solution that specific concentration is divided to be 85%, using the ultrasonic wave extraction 5min of 0.6MHz, then removes solvent, respectively obtains each original
Expect the extracting solution of medicine；
(3) after crushing sweet basil leaf 31g, felwort rhizome 14g and Cajeputtree Leaf 28g respectively, using supercritical CO2Extraction
It takes, CO2Flow is 8kg/h, pressure 25MPa, extraction time 1.5h, respectively obtains the extracting solution of each bulk pharmaceutical chemicals；
(4) after crushing lotus leaf 16g and kuh-seng complete stool 15g respectively, using supercritical CO2Extraction, CO2Flow is 10kg/
H, pressure 15MPa, extraction time 1h respectively obtain the extracting solutions of each bulk pharmaceutical chemicals；
(5) extracting solution of bulk pharmaceutical chemicals each in above-mentioned steps is mixed to get the Chinese medicine composition.
Comparative example 2
(1) by fennel seeds seed 18g, perilla seed 21g, honeysuckle 14g, lilac 16g, mulberry leaf 20g and Chinese violet complete stool
19g mixing after crushing, adds in the ethanol solution that the concentration of volume percent that 20 times of bulk pharmaceutical chemicals powder is measured is 65%, uses
The ultrasonic wave extraction 7min of 1.5MHz, then removes solvent, obtains extracting solution A；
(2) sweet basil leaf 31g, felwort rhizome 14g, Cajeputtree Leaf 28g, lotus leaf 16g and kuh-seng complete stool 15g are mixed, powder
After broken, using supercritical CO2Extraction, CO2Flow is 8kg/h, and pressure 25MPa, extraction time 1.5h obtain extracting solution B；
(3) extracting solution A and extracting solution B is mixed to get the Chinese medicine composition.
Comparative example 3
(1) by fennel seeds seed 18g, perilla seed 21g, honeysuckle 14g, lilac 16g, mulberry leaf 20g and Chinese violet complete stool
19g mixing after crushing, adds in the ethanol solution that the concentration of volume percent that 8 times of bulk pharmaceutical chemicals powder is measured is 85%, using 0.6MHz
Ultrasonic wave extraction 5min, then remove solvent, obtain extracting solution A；
(2) sweet basil leaf 31g, felwort rhizome 14g, Cajeputtree Leaf 28g, lotus leaf 16g and kuh-seng complete stool 15g are mixed, powder
After broken, using supercritical CO2Extraction, CO2Flow is 8kg/h, and pressure 25MPa, extraction time 1.5h obtain extracting solution B；
(3) extracting solution A and extracting solution B is mixed to get the Chinese medicine composition.
Effect example 1
This effect example compare the present invention prepare Chinese medicine composition, comparative example active Chinese drug component compositions and only adopt
Effect is inhibited bacteria with chemical preservative, is as follows：
The fusing shape agar medium of 20ml is injected into each culture dish, respectively by strain common in cosmetics, including gold
Staphylococcus aureus liquid, Escherichia coli liquid, Pseudomonas aeruginosa liquid, Salmonella bacterium solution, bacillus cereus, aerobacteria and sand Lei Shi
Bacterium is uniformly mixed with culture medium, treats its cooling.Disk filter paper is respectively put into the Chinese medicine composition of 10g embodiments 1,10g is implemented
In the Chinese medicine composition and the Chinese medicine composition of 10g comparative examples 1 of example 5, the Chinese medicine composition of 10g comparative examples 2,10g comparative examples 3
A moment is impregnated in drug composition and 10g propylparaben solution, the center for being placed in the culture medium flat plate that carries disease germs is taken out, covers
Lid culture 2-3 days observes the presence or absence of inhibition zone and size, concrete outcome around filter paper disk and is shown in Table 1.
1 biocidal property testing result of table
With reference to the sensibility evaluation criteria of antibiotic property drug, from table 1 it follows that Chinese medicine composition provided by the invention
There is preferable biocidal property for strain common in cosmetics, chemical preservative can be substituted and be added in cosmetics.
Effect example 2
By the Chinese medicine composition of embodiment 1-8 and the medicine activity compositions of comparative example 1, place three months at room temperature,
By having seen whether that precipitation, discoloration and peculiar smell measure degree of oxidation, concrete outcome is shown in Table 2.
2 oxidation results of table
| Serial number | Whether there is precipitation | Color | Smell |
| Embodiment 1 | Nothing | It is transparent | Free from extraneous odour |
| Embodiment 2 | Nothing | It is transparent | Free from extraneous odour |
| Embodiment 3 | Nothing | It is transparent | Free from extraneous odour |
| Embodiment 4 | Nothing | It is transparent | Free from extraneous odour |
| Embodiment 5 | Nothing | It is transparent | Free from extraneous odour |
| Embodiment 6 | Nothing | It is transparent | Free from extraneous odour |
| Embodiment 7 | Nothing | It is transparent | Free from extraneous odour |
| Embodiment 8 | Nothing | It is transparent | Free from extraneous odour |
| Comparative example 1 | There is precipitation, become muddy | Yellow | There is acid smell |
From Table 2, it can be seen that Chinese medicine composition provided by the invention have preferable antioxidant effect, stability compared with
It is good.
Effect example 3
The Chinese medicine composition of embodiment 1-8 is applied to after subject's ear on skin, subject does not occur skin hair after 1h
Symptom that is red, itching asks subject to be given a mark to use feeling (5 points of systems), and the more high then use feeling of score value is better, and tested crowd is
30 people, point value of evaluation are arithmetic mean of instantaneous value, are specifically shown in Table 3.
3 use feeling of table is tested
| Embodiment | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
| Scoring | 4.87 | 4.76 | 4.83 | 4.72 | 4.91 | 4.83 | 4.79 | 4.68 |
As can be seen from Table 3, subject's use feeling is preferable, does not occur the symptom of skin discomfort.
Obviously, the above embodiments are merely examples for clarifying the description, and is not intended to limit the embodiments.It is right
For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of variation or
It changes.There is no necessity and possibility to exhaust all the enbodiments.And the obvious variation thus extended out or
Among changing still in the protection domain of the invention.
Claims (10)
1. a kind of Chinese medicine composition, which is characterized in that include the bulk pharmaceutical chemicals of following parts by weight：
Fennel seeds seed 16-20 parts by weight, perilla seed 18-24 parts by weight, sweet basil leaf 28-34 parts by weight, Cajeputtree Leaf 24-32 weight
Part, mulberry leaf 15-25 parts by weight, felwort rhizome 10-18 parts by weight, lotus leaf 14-19 parts by weight, honeysuckle 10-18 parts by weight, purple
Flower Chinese violet complete stool 15-23 parts by weight, kuh-seng complete stool 11-17 parts by weight and lilac 13-19 parts by weight.
2. Chinese medicine composition according to claim 1, which is characterized in that include the bulk pharmaceutical chemicals of following parts by weight：
18 parts by weight of fennel seeds seed, 21 parts by weight of perilla seed, 31 parts by weight of sweet basil leaf, 28 parts by weight of Cajeputtree Leaf, 20 weight of mulberry leaf
Measure part, 14 parts by weight of felwort rhizome, 16 parts by weight of lotus leaf, 14 parts by weight of honeysuckle, 19 parts by weight of Chinese violet complete stool, kuh-seng
16 parts by weight of 15 parts by weight of complete stool and lilac；Or
16 parts by weight of fennel seeds seed, 24 parts by weight of perilla seed, 34 parts by weight of sweet basil leaf, 32 parts by weight of Cajeputtree Leaf, 25 weight of mulberry leaf
Measure part, 18 parts by weight of felwort rhizome, 19 parts by weight of lotus leaf, 18 parts by weight of honeysuckle, 23 parts by weight of Chinese violet complete stool, kuh-seng
19 parts by weight of 17 parts by weight of complete stool and lilac；Or
20 parts by weight of fennel seeds seed, 18 parts by weight of perilla seed, 28 parts by weight of sweet basil leaf, 24 parts by weight of Cajeputtree Leaf, 15 weight of mulberry leaf
Measure part, 10 parts by weight of felwort rhizome, 14 parts by weight of lotus leaf, 10 parts by weight of honeysuckle, 15 parts by weight of Chinese violet complete stool, kuh-seng
13 parts by weight of 11 parts by weight of complete stool and lilac；Or
19 parts by weight of fennel seeds seed, 22 parts by weight of perilla seed, 30 parts by weight of sweet basil leaf, 31 parts by weight of Cajeputtree Leaf, 17 weight of mulberry leaf
Measure part, 16 parts by weight of felwort rhizome, 18 parts by weight of lotus leaf, 16 parts by weight of honeysuckle, 17 parts by weight of Chinese violet complete stool, kuh-seng
15 parts by weight of 13 parts by weight of complete stool and lilac.
3. Chinese medicine composition according to claim 1 or 2, which is characterized in that further include：Leaf of bamboo 18-25 parts by weight, the wide leaves of pulse plants
Fragrant cauline leaf 14-20 parts by weight, hypericum perforatum complete stool 6-12 parts by weight, camellia seed 5-10 parts by weight, Chinese torreya aril 4-8 weight
Part, rhodiola root rhizome 12-20 parts by weight and stem of Dendrobium 7-11 parts by weight.
4. Chinese medicine composition according to claim 3, which is characterized in that 22 parts by weight of the leaf of bamboo, 17 weight of Pogostemon cablin cauline leaf
Part, 9 parts by weight of hypericum perforatum complete stool, 7 parts by weight of camellia seed, 6 parts by weight of Chinese torreya aril, 16 parts by weight of rhodiola root rhizome and stone
9 parts by weight of dry measure used in former times stem；Or
18 parts by weight of the leaf of bamboo, 20 parts by weight of Pogostemon cablin cauline leaf, 12 parts by weight of hypericum perforatum complete stool, 10 parts by weight of camellia seed, Chinese torreya
11 parts by weight of 8 parts by weight of aril, 20 parts by weight of rhodiola root rhizome and stem of Dendrobium；Or
25 parts by weight of the leaf of bamboo, 14 parts by weight of Pogostemon cablin cauline leaf, 6 parts by weight of hypericum perforatum complete stool, 5 parts by weight of camellia seed, Chinese torreya are false
4 parts by weight of kind skin, 7 parts by weight of 12 parts by weight of rhodiola root rhizome and stem of Dendrobium；Or
20 parts by weight of the leaf of bamboo, 19 parts by weight of Pogostemon cablin cauline leaf, 10 parts by weight of hypericum perforatum complete stool, 8 parts by weight of camellia seed, Chinese torreya are false
5 parts by weight of kind skin, 8 parts by weight of 15 parts by weight of rhodiola root rhizome and stem of Dendrobium.
A kind of 5. method for preparing the Chinese medicine composition described in claims 1 or 2, which is characterized in that include the following steps：
(1) fennel seeds seed, perilla seed, honeysuckle and lilac are mixed, after crushing, adds in what 10-30 times of bulk pharmaceutical chemicals powder was measured
Ethanol solution A, ultrasonic extraction then remove solvent, obtain extracting solution A；
The concentration of volume percent of the ethanol solution A is 60-70%；
(2) after mulberry leaf and Chinese violet complete stool being mixed, crushed, bulk pharmaceutical chemicals 5-10 times of ethanol solution B measured of powder, ultrasound are added in
Extraction, then removes solvent, obtains extracting solution B；
The concentration of volume percent of the ethanol solution B is 75-95%；
(3) sweet basil leaf, felwort rhizome and Cajeputtree Leaf are mixed, after crushing, using supercritical CO2Extraction, obtains extracting solution C；
(4) after lotus leaf and kuh-seng complete stool being mixed, crushed, using supercritical CO2Extraction, obtains extracting solution D；
(5) the extracting solution A, extracting solution B, extracting solution C, extracting solution D are uniformly mixed to get the Chinese medicine composition.
A kind of 6. method for preparing the Chinese medicine composition described in claim 3 or 4, which is characterized in that include the following steps：
(1) fennel seeds seed, perilla seed, honeysuckle, lilac and camellia seed are mixed, after crushing, adds in bulk pharmaceutical chemicals powder 10-30
The ethanol solution A of amount, ultrasonic extraction then remove solvent, obtain extracting solution A ' again；
The concentration of volume percent of the ethanol solution A is 60-70%；
(2) mulberry leaf, Chinese violet complete stool, the leaf of bamboo and hypericum perforatum complete stool are mixed, after crushing, adds in 5-10 times of bulk pharmaceutical chemicals powder
The ethanol solution B of amount, ultrasonic extraction then remove solvent, obtain extracting solution B '；
The concentration of volume percent of the ethanol solution B is 75-95%；
(3) by sweet basil leaf, Cajeputtree Leaf, felwort rhizome, Pogostemon cablin cauline leaf, Chinese torreya aril, rhodiola root rhizome and stem of Dendrobium
After mixing, crushing, using supercritical CO2Extraction, obtains extracting solution C '；
(4) after lotus leaf and kuh-seng complete stool being mixed, crushed, using supercritical CO2Extraction, obtains extracting solution D '；
(5) the extracting solution A ', extracting solution B ', extracting solution C ', extracting solution D ' are uniformly mixed to get the Chinese medicine composition.
7. according to the preparation method described in claim 5-6 any one, which is characterized in that use 0.5-2MHz in step (1)
Ultrasonic wave extraction 4-10min；
And/or using the ultrasonic wave extraction 3-6min of 0.2-1MHz in step (2).
8. according to the preparation method described in claim 5-7 any one, which is characterized in that CO in the step (3)2Flow is
5-10kg/h, pressure 20-30MPa, extraction time 1-2h；
And/or CO in the step (4)2Flow is 8-12kg/h, pressure 12-18MPa, extraction time 0.5-1.5h.
9. the Chinese medicine composition described in claim 1-4 any one is in protection cosmetics from the purposes in germ contamination.
10. purposes according to claim 9, which is characterized in that the additive amount of the Chinese medicine composition is the cosmetics
The 0.01-0.5wt% of gross mass.
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