CN102885994A - Traditional Chinese medicine composition for inhibiting seborrheic alopecie and preparation method thereof - Google Patents
Traditional Chinese medicine composition for inhibiting seborrheic alopecie and preparation method thereof Download PDFInfo
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- CN102885994A CN102885994A CN2012104148615A CN201210414861A CN102885994A CN 102885994 A CN102885994 A CN 102885994A CN 2012104148615 A CN2012104148615 A CN 2012104148615A CN 201210414861 A CN201210414861 A CN 201210414861A CN 102885994 A CN102885994 A CN 102885994A
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Abstract
The invention provides a traditional Chinese medicine composition for inhibiting seborrheic alopecie and a preparation method thereof. The traditional Chinese medicine composition comprises the following materials according to parts by weight: fructus cnidii, citronella, kuh-seng, milk veteh, Radix Polygoni Multiflori Preparat, arborvitae, angelica and pepper, wherein relative to 100 parts of the traditional Chinese medicine composition by weight, each material accounts for not lower than 0.1 part by weight. The preparation method comprises the following steps: crashing each material in the traditional Chinese medicine composition and sieving through a 200-mesh sieve; controlling the extractive temperature at the temperature of 20-35 DEG C; filtering an extract under the condition that the pressure is normal pressure or negative pressure; soaking for 7-15d with 20-70% ethanol liquor, and stirring in multiple times during the period; and finally taking filtering medium for cryoconcentration.
Description
Technical field
The invention belongs to the household chemicals technical field, be specifically related to a kind of Chinese medicine composition that suppresses seborrheic alopecia and preparation method thereof.
Background technology
Seborrheic alopecia (seb rrhe ic a lopec ia, SA), have another name called male pattern alopecia (malepattern alopec ia, MPA), androgenetic alopecia (androgen icalopec ia, AGA), often show as the gradual alopecia that hair is greasy, consider more, have obvious scratchiness, volume temporo district and top to be worth doing, then form great number.The male who is apt to occur in 20 ~ 30 years old is between twenty and fifty, also claims male pattern alopecia (prem ature alopecia).Seborrheic alopecia is the clinical commonly encountered diseases of department of dermatologry, frequently-occurring disease, also is one of refractory disease, because primary disease hinders appearance, affect attractive in appearancely, often brings very large stress and psychological burden to the patient, so the research of seborrheic alopecia is paid attention to widely.Modern medicine study shows that inherited genetic factors is the one of the main reasons that seborrheic alopecia occurs, and heredodiathesis makes hair increase androgenic biological action sensitivity; And Hyperandrogenism or be this pathogenetic principal element to responsive the increasing of androgen, 5 alpha-reductases have important related with this disease unusually.Except foreign genetic element, long-term psychentonia, drinking and eating irregularly, psychological unbalance and courses of infection (such as Malassezia furfur, propionibacterium acnes etc.) are for bringing out or increase the weight of the key factor of primary disease.Therapeutic scheme for seborrheic alopecia comprises doctor trained in Western medicine and tcm therapy, and doctor trained in Western medicine is mainly passed through the androgenic endo-medicine finasteride of antagonism antagonism androgen and external minoxidil tincture, the side effect that exist user to feminize, skin irritation is large; Chinese traditional treatment has mainly used Traditional Chinese medical theory to carry out Chinese herbal treatment, present existing invention is mainly based on the differential diagnosis of diseases and the dialectical principle that combines of Chinese traditional treatment alopecia, natural plant by screening nourishing blood to tranquillize the mind, dispersing the stagnated live-QI to relieve the stagnation of QI, QI invigorating hair growth promoting comes prescription, but these Chinese herb compounds or related preparations are seldom for the target spot that causes infected by microbes, especially for the wherein inhibition of the high Malassezia furfur that detects of seborrheic alopecia and propionibacterium acnes propagation, therefore be necessary to propose to improve.
Summary of the invention
The present invention is directed to seborrheic alopecia, Chinese medicine composition and preparation method thereof of the inhibition seborrheic alopecia of a kind of more effectively special control scalp and hair infected by microbes is provided.
The technical solution used in the present invention: suppress the Chinese medicine composition of seborrheic alopecia, comprise the raw material of following weight parts: Fructus Cnidii, Herba Cymbopogonis Citrari, Radix Sophorae Flavescentis, the Radix Astragali, Radix Polygoni Multiflori Preparata, Cacumen Platycladi, Radix Angelicae Sinensis and Pericarpium Zanthoxyli, wherein with respect to the Chinese medicine composition of 100 weight portions, affiliated every kind of parts by weight of raw materials is not less than 0.1.
Preferably, the raw material that comprises following weight parts:
A kind of preparation method that suppresses the Chinese medicine composition of seborrheic alopecia also is provided, various raw materials in the Chinese medicine composition are pulverized and are crossed 200 mesh sieves, control is extracted temperature at 20-35 ℃, pressure is to leach extract under normal pressure or the negative pressure condition, with 20-70% alcohol solution dipping 7-15d, repeatedly stir during this time, get at last the filtrate cryoconcentration.
Further, described extract adds additive, described additive can freely be selected one or more of following composition, comprises diluent, wetting agent, thickening agent, surfactant, increases penetrating agent, antiseptic, pH adjusting agent, antibacterial, stabilizing agent, buffer agent, excipient, spice, dyestuff and their mixture.
The present invention compared with prior art stresses control and eliminates scalp infected by microbes and anti-inflammatory effect, the collaborative microcirculatory herbal prescription of scalp blood that increases, can effectively treat the seborrheic alopecia symptom that causes because of male's androgenetic, reduce the probability of the early stage alopecia of male, alopecia areata.Its pure Chinese medicinal preparation meets cosmetics health standard and sterile products management regulation, and preparation is simple, production cost is low and use convenience, can be used in the prescription of caused by cosmetics for special use and sterile products, such as anticreep tincture, anticreep essence, anticreep shampoo etc.
The specific embodiment
A kind of embodiment of the present invention is described below.
The Chinese medicine composition that suppresses seborrheic alopecia, the raw material that comprises following weight parts: Fructus Cnidii, Herba Cymbopogonis Citrari, Radix Sophorae Flavescentis, the Radix Astragali, Radix Polygoni Multiflori Preparata part, Cacumen Platycladi, Radix Angelicae Sinensis and Pericarpium Zanthoxyli, according to above compositions wherein with respect to this Anti-hair loss compositions of 100 weight portions as raw material, affiliated every kind of parts by weight of raw materials is not less than 0.1, preferably within 0.1-5.
The solution that extracts for this Chinese medicine composition contains water, alcohols and/or the ketones solvent of medicine, cosmetics regulation.Extracting method mainly is the raw material in the Chinese medicine composition to be pulverized and crossed 200 mesh sieves, control is extracted temperature at 20-35 ℃, pressure is to leach abstract under normal pressure or the negative pressure condition, with extract 20-70% alcohol solution dipping 7-15d, repeatedly stir during this time, get at last the filtrate cryoconcentration and get final product.Simultaneously, can further add additive in the said extracted thing, additive can freely be selected one or more of following composition, comprises diluent, wetting agent, thickening agent, surfactant, increases penetrating agent, antiseptic, pH adjusting agent, antibacterial, stabilizing agent, buffer agent, excipient, spice, dyestuff etc. and their mixture.
The medium-height grass compositions can be made following form, comprises shampoo, essence, spray etc., or occurs such as cream, unguentum, gel etc. with semi-solid form.
In recent years clinical trial and observation are verified, in the scalp infringement of patients with seborrheic dermatitis, the overwhelming majority can be found the oval Malassezia furfur, its quantity can account for the total flora of scalp approximately more than 82%, the lipotropy of Malassezia furfur is very strong, can produce esterase and Triglycerides in Serum is decomposed into the zest fatty acid, cause scalp inflammation, dandruff that promoting epidermization occurs and affect, inflammation can further accumulate and form seborrheic dermatitis and accompany alopecia.In addition, the antibacterial accompanying infections such as propionibacterium acnes and staphylococcus (mainly being staphylococcus aureus and staphylococcus epidermidis) also are one of risk factors of seborrheic alopecia.
Reach the deficiency of hair infected by microbes outward for the effective control head Intradermal of shortage during Chinese and western medicine was treated seborrheic alopecia in the past, this research is carried out the research of Chinese herb compound for the major microorganisms such as aerobic fungus (Malassezia furfur), Anaerobic Bacteria (propionibacterium acnes) and the facultative aerobic bacteria (staphylococcus aureus and staphylococcus epidermidis) that cause seborrheic alopecia, by the combination of various effective folk prescriptions, cooperation has bactericidal, scalp irritation telangiectasis and strengthens the Chinese herbal medicine formation compound recipe of permeability effect.The inside and outside corresponding Malassezia furfur of scalp, propionibacterium acnes and staphylococcus can effectively be killed and suppress to this compound recipe, reduces the seborrheic alopecia odds, increases the cooperative effect for the treatment of corresponding symptom with other medicaments and chemicals.
The present invention stresses control and eliminates scalp infected by microbes and anti-inflammatory effect, and the collaborative microcirculatory herbal prescription of scalp blood that increases can effectively be treated the seborrheic alopecia symptom that causes because of male's androgenetic, reduces the probability of the early stage alopecia of male, alopecia areata.Its pure Chinese medicinal preparation meets cosmetics health standard and sterile products management regulation, and preparation is simple, production cost is low and use convenience.Can be used in the prescription of caused by cosmetics for special use and sterile products, such as anticreep tincture, anticreep essence, anticreep shampoo etc.
Latin formal name used at school and the action and efficacy thereof of table 1 herbal raw material
Table 2 Chinese medicine composition withdrawal ratio embodiment
Effect example 1: above-described embodiment 1 is carried out the effect experiment, use the mode trickle biology to carry out Bactericidal test, wherein the Malassezia furfur type strain is ATCC14521, propionibacterium acnes ATCC65102, and staphylococcus aureus pattern bacterium is strains A TCC 6538.
Adopt different cultural methods for different microorganisms, adopt fungi culture medium such as Malassezia furfur, concussion is cultivated, propionibacterium acnes adopts the anaerobism cultural method, and staphylococcus aureus adopts the concussion of LB bacteria culture media to cultivate, and identifies first and in a small amount inoculation, behind the quantitative micro organism quantity of turbidimetry it is coated in the culture dish, standard Oxford cup adds an amount of medicament and contrast agents, and each strain is done 4 repetitions, gets the inhibition zone meansigma methods behind the cultivation 24h.
Reference standard bacteria inhibition assay method.Inhibition zone〉20mm is extremely sensitive, and 10-20mm is medium sensitivity, and＜10mm is drug resistance.
Three kinds of employed positive contrast antibacterial of different microorganisms are all metronidazole, and this antibacterial is widely used in sterile products and the cosmetics as conventional antibacterial.Be Gao Min by visible this herbal composite of experimental data to Malassezia furfur, quick in to propionibacterium acnes and staphylococcus aureus being, slightly be better than classical antibacterial metronidazole)
1 pair of different mode microorganism of table 3 embodiment fungistatic effect
* be the data corresponding with microbial inhibitor in the bracket
2 pairs of above-described embodiments of effect example 1 carry out the effect experiment, use alopecia volunteer totally 30 people, meet Hamilton alopecia classification II-IV through evaluation, test was used this product totally 60 days, added up alopecia quantity, per 10 days per 10 day early morning to alopecia scalp sampling determination bran Blighted chlosma quantity.Alopecia quantity with early morning with 30 ℃ of warm water washing hairs 5 minutes, calculate alopecia quantity with filtered through gauze.
The method of inspection of Malassezia furfur is pasted at the most serious position of the scalp product dandruff with adhesive tape of paste, gets same area at every turn, and then with the sticking thing of getting of sterilized water eluting, suitably dilution is with counting behind the fungi culture medium cultivation 24h.
Table 4 embodiment 1 uses the impact of patient's alopecia quantity and the impact of scalp Malassezia furfur quantity
Can obviously find from top list data, said composition can be slowed down rapidly alopecia speed to hair loss patient after using, and alopecia quantity reduces 54.38% after 60 days.The effect that obvious inhibition is arranged for scalp chlosma quantity simultaneously uses after 60 days the quantity of bran skin chlosma to reduce approximately 49%.Be anticreep and the effect that suppresses prescribed microorganism all clearly.
Above-described embodiment is preferred embodiment of the present invention, is not to limit the scope of the present invention, therefore all equivalences of being done with the described content of claim of the present invention change, all should be included within the claim scope of the present invention.
Claims (4)
1. the Chinese medicine composition that suppresses seborrheic alopecia is characterized in that comprising the raw material of following weight parts: Fructus Cnidii, Herba Cymbopogonis Citrari, Radix Sophorae Flavescentis, the Radix Astragali, Radix Polygoni Multiflori Preparata, Cacumen Platycladi, Radix Angelicae Sinensis and Pericarpium Zanthoxyli, wherein with respect to the Chinese medicine composition of 100 weight portions, affiliated every kind of parts by weight of raw materials is not less than 0.1.
2. the Chinese medicine composition of inhibition seborrheic alopecia according to claim 1 is characterized in that: the raw material that comprises following weight parts:
3. the method for preparing the Chinese medicine composition of inhibition seborrheic alopecia as claimed in claim 1 or 2, it is characterized in that the various raw materials in the Chinese medicine composition are pulverized and mistake 200 mesh sieves, control is extracted temperature at 20-35 ℃, pressure is to leach extract under normal pressure or the negative pressure condition, with 20-70% alcohol solution dipping 7-15d, repeatedly stir during this time, get at last the filtrate cryoconcentration.
4. the preparation method of the Chinese medicine composition of inhibition seborrheic alopecia according to claim 3, it is characterized in that: described extract adds additive, described additive can freely be selected one or more of following composition, comprises diluent, wetting agent, thickening agent, surfactant, increases penetrating agent, antiseptic, pH adjusting agent, antibacterial, stabilizing agent, buffer agent, excipient, spice, dyestuff and their mixture.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103417940A (en) * | 2013-08-05 | 2013-12-04 | 谢明臣 | Prescription combination for treating seborrheic aiopecia and preparation method of prescription combination |
| CN104224631A (en) * | 2014-09-28 | 2014-12-24 | 广州市络捷生物科技有限公司 | Plant extract composition applicable to androgenetic alopecia, and preparation method and application thereof |
Citations (4)
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| CN1222344A (en) * | 1998-01-09 | 1999-07-14 | 张天福 | Chinese medicinal shampoo of natural plant ingredients |
| CN1742861A (en) * | 2005-09-30 | 2006-03-08 | 张七一 | Chinese medicine external-use liniment for treating lipsotrichia and regenerating hair |
| CN101357201A (en) * | 2008-09-16 | 2009-02-04 | 杨运金 | Multipurpose traditional Chinese medicine and preparation method thereof |
| CN102397194A (en) * | 2011-11-18 | 2012-04-04 | 大连得达科技发展有限公司 | Anti-hair loss and deoiling liquid shampoo |
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2012
- 2012-10-25 CN CN2012104148615A patent/CN102885994A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1222344A (en) * | 1998-01-09 | 1999-07-14 | 张天福 | Chinese medicinal shampoo of natural plant ingredients |
| CN1742861A (en) * | 2005-09-30 | 2006-03-08 | 张七一 | Chinese medicine external-use liniment for treating lipsotrichia and regenerating hair |
| CN101357201A (en) * | 2008-09-16 | 2009-02-04 | 杨运金 | Multipurpose traditional Chinese medicine and preparation method thereof |
| CN102397194A (en) * | 2011-11-18 | 2012-04-04 | 大连得达科技发展有限公司 | Anti-hair loss and deoiling liquid shampoo |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103417940A (en) * | 2013-08-05 | 2013-12-04 | 谢明臣 | Prescription combination for treating seborrheic aiopecia and preparation method of prescription combination |
| CN104224631A (en) * | 2014-09-28 | 2014-12-24 | 广州市络捷生物科技有限公司 | Plant extract composition applicable to androgenetic alopecia, and preparation method and application thereof |
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Application publication date: 20130123 |