CN108124880A - The Pesticidal combination of the mite nitrile of azoles containing second and mono-amitraz hydrochloride - Google Patents

The Pesticidal combination of the mite nitrile of azoles containing second and mono-amitraz hydrochloride Download PDF

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Publication number
CN108124880A
CN108124880A CN201810111543.9A CN201810111543A CN108124880A CN 108124880 A CN108124880 A CN 108124880A CN 201810111543 A CN201810111543 A CN 201810111543A CN 108124880 A CN108124880 A CN 108124880A
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China
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mono
pesticidal combination
mite nitrile
amitraz hydrochloride
azoles
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CN201810111543.9A
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Inventor
陈炳旭
池艳艳
冯日碧
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Plant Protection Research Institute Guangdong Academy of Agricultural Sciences
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Plant Protection Research Institute Guangdong Academy of Agricultural Sciences
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Priority to CN201810111543.9A priority Critical patent/CN108124880A/en
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/52—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing groups, e.g. carboxylic acid amidines

Abstract

The present invention relates to pesticide fields, disclose a kind of Pesticidal combination, and active constituent is second azoles mite nitrile and mono-amitraz hydrochloride, and the mass ratio of the two is 50:1~1:50, preferably than being 5:1~1:5.Pesticidal combination of the present invention can be made into wettable powder, water dispersible granules, suspending agent, suspension emulsion.Significant synergistic effect is shown in a certain range after two groups of active constituents compounding of the present invention, can be reduced dosage, be reduced cost；It being capable of delaying drug resistance；It is safe, environmentally friendly environmental protection.

Description

The Pesticidal combination of the mite nitrile of azoles containing second and mono-amitraz hydrochloride
Technical field
The invention belongs to technical field of pesticide, are related to the Pesticidal combination of the mite nitrile of azoles containing second and mono-amitraz hydrochloride, are used for Prevent crops class pest.
Background technology
Second azoles mite nitrile：CA accession number is 1253429-01-4, and chemical name is（Z）-2-（4- tert-butyl-phenyls）- 2- cyanogen Base -1-（1- ethyl -3- methylpyrazole -5- bases）Vinyl -2,2-Dimethylpropionic acid ester.It is white solid, and fusing point is 92 ~ 93 DEG C, dimethylformamide, acetonitrile, acetone, methanol, ethyl acetate, dichloromethane etc. are soluble in, dissolves in petroleum ether, heptane, it is difficult It is dissolved in water.
Structural formula：
Second azoles mite nitrile is the product for changing the independent research of pesticide chemical research and development Co., Ltd in Shenyang, is using nitrile pyrrole mite ester as guideization Object is closed, the novel propylene nitrile compounds with high acaricidal activity found by structural modification.The medicament is low to mammal Poison, and to the non-target organism such as safety such as honeybee, bird, fish.It is 30% suspending agent that it, which processes dosage form, available for preventing the red spider of citrus The evil mites such as spider, apple tetranychus, cotton spider mites and vegetables tetranychid.
Mono-amitraz hydrochloride：English name：Semiamitraz chloride, chemical name：N- (2,4- dimethyl benzenes Base)-N '-methylrnethwirnidamide hydrochloride, molecular formula：C10H15N2Cl。
Structural formula：
Mono-amitraz hydrochloride is a kind of efficient organic nitrogen pesticide, mainly inhibits monoamine oxidase, to insect CNS Non-cholinergic cynapse can induce direct excitation, have action of contace poison, have lethality to mite ovum, deutonymph.Have great Aphid activity is killed, also has certain activity to pink bollworm, Yellow Rice Borer and striped rice borer.To ladybug, Chrysopa, carnivorism stinkbug, food mite Ladybug, honeybee, silkworm are safer.
The long-time service of single insecticide so that resistance enhances, and dosage is continuously increased, and environmental pollution aggravates.Two kinds of medicaments Compounding, can effectively solve the problem that this problem.Inventor has found second by the research of a large amount of indoor biometrics and field control effectiveness test Azoles mite nitrile and mono-amitraz hydrochloride are combined application, and synergistic effect is apparent, can reduce dosage, delaying drug resistance, to environment Safety.
Invention content
It is an object of the present invention to propose that a kind of synergistic effect is apparent, it being capable of delaying drug resistance, the desinsection group of reduction usage amount Close object.
To solve the above-mentioned problems, the technical solution adopted in the present invention is：
The Pesticidal combination of the mite nitrile of azoles containing second and mono-amitraz hydrochloride proposed by the present invention, it is characterised in that：The Insecticidal combinations Object contains active constituent second azoles mite nitrile and active constituent mono-amitraz hydrochloride.
The Pesticidal combination contains active constituent second azoles mite nitrile and active constituent mono-amitraz hydrochloride, the mass ratio of the two It is 50:1~1:50, the mass ratio of the two is preferably 5:1~1:5.
The Pesticidal combination, it is characterised in that：The gross mass percentage composition of active constituent in the Pesticidal combination It is 10% ~ 80%.
The Pesticidal combination can be processed into the arbitrary dosage form agriculturally allowed, wherein more preferably dosage form have it is wettable Property pulvis, water dispersible granules, suspending agent, suspension emulsion.
Dosage form of the present invention can be prepared as the method well known to those skilled in the art.Wherein, more than preparation Wetting agent, dispersant, disintegrant, emulsifier, antifreezing agent, preservative, antifoaming agent, thickener, filler used in various preparations is equal It is known to the skilled person.
The wetting agent is selected from：Lauryl sodium sulfate, neopelex, pull open powder X, wetting and penetrating agent F, It is one or more in spaonin powder, silkworm excrement, spaonin powder.
The dispersant is selected from：It is alkylnaphthalene sulfonate, double（Alkyl）Naphthalenesulfonate formaldehyde condensation compound, naphthalenesulfonateformaldehyde formaldehyde contracting Close object, aryl phenol polyoxyethylene succinate sulfonate, octylphenol polyethylene oxyethylene group ether sulfate, polycarboxylate, sulfomethylated lignin Hydrochlorate, to methoxyl group fatty acyl anilinesulfonic acid, APES formaldehyde condensation products sulfat, alkyl benzene calcium sulfonate Salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkyl phenol polyoxyethylene ether, aliphatic amine polyoxyethylene ether, polyoxyethylene carboxylate, ester It is one or more in polyoxyethylene ether.
The disintegrant is selected from：In bentonite, ammonium sulfate, citric acid, urea, aluminium chloride, succinic acid, sodium bicarbonate It is one or more.
The emulsifier is selected from：Alkyl benzene sulfonate calcium salt, styrene polyoxyethylene ether ammonium sulfate salt, alkyl biphenyl ether two Sulfonic acid magnesium salts, triethanolamine salt, phenethyl phenol polyethenoxy ether, 506#, 600#, 700#, NP-10 phosphate, OP-10 phosphoric acid It is one or more in ester, castor oil polyoxyethylene ether, sorbester p17, Tween 80,602#.
The antifreezing agent is selected from：It is one or more in ethylene glycol, propylene glycol, glycerine, polyethylene glycol.
The preservative is selected from：Sodium benzoate, sodium propionate, butyl p-hydroxybenzoate, dimethyl fumarate, sorbic acid It is one or more in potassium, sodium Diacetate.
The antifoaming agent is selected from：C8~10Aliphatic alcohols, C10~20Saturated fat acids（Such as capric acid）And amide, silicone oil, have It is one or more in machine silicone compound.
The thickener is selected from：Xanthans, hydroxymethyl cellulose, hydroxyethyl cellulose, methylcellulose, magnesium silicate It is one or more in aluminium, polyvinyl alcohol.
The filler is selected from：In kaolin, diatomite, bentonite, attapulgite, white carbon, starch, precipitated calcium carbonate It is one or more.
The Pesticidal combination, for preventing and kill off acarina pest and homoptera pest, especially to citrus/red spider, The prevention of lichee/tetranychid.
The advantage of the invention is that：The two compounds, and shows significant synergistic effect in a certain range, can reduce use Dose reduces cost；It being capable of delaying drug resistance；It is safe, environmentally friendly environmental protection.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, present invention specific examples below It illustrates, but the present invention is limited to absolutely not this.Percentage in embodiment is weight percentage.
Implementation of an application example one：Second azoles mite nitrile and mono-amitraz hydrochloride compound product example of formulations（Following content is folding Hundred percentage compositions）, but the present invention is not limited to the proportional region in following embodiment.
The mass ratio that second azoles mite nitrile and mono-amitraz hydrochloride are formed is 50:1~1:50.Active ingredient in usual composition Gross mass percentage composition for 10% ~ 80%, preferably 10% ~ 60%.According to different preparation types, active constituent content range It is different.In general, the gross mass of solid pharmaceutical preparation active ingredient is 10% ~ 80%, preferably 10% ~ 60%；Liquid preparation is effective The gross mass of ingredient is 10% ~ 50%, preferably 10% ~ 40%.
Pesticidal combination of the present invention can be processed into the arbitrary dosage form agriculturally allowed, wherein more preferably dosage form There are wettable powder, water dispersible granules, suspending agent, suspension emulsion.
Wettable powder（Example of formulations 1 ~ 2）
When above-described Pesticidal combination is wettable powder, following component is included in preparation：Second azoles mite nitrile 1% ~ 40%, Dan Jia Amidine hydrochloride 1% ~ 40%, dispersant 2% ~ 10%, wetting agent 2% ~ 8%, filler supplement surplus.
The specific procedure of processing of Pesticidal combination wettable powder is：According to formula by active constituent second azoles mite nitrile, activity Ingredient mono-amitraz hydrochloride, dispersant, wetting agent, filler mixing, are uniformly mixed in mixed cylinder, after airslide disintegrating mill crushes It remixes uniformly, you can wettable powder of the present invention is made.
1 30% second azoles mite nitrile mono-amitraz hydrochloride wettable powder of example of formulations
Second azoles mite nitrile 25%, mono-amitraz hydrochloride 5%, lignosulfonates（Dispersant）8%th, pull open powder X（Wetting agent）4%th, swelling Soil adds to 100%, and 30% second azoles mite nitrile mono-amitraz hydrochloride wettable powder is made.
2 15% second azoles mite nitrile mono-amitraz hydrochloride wettable powder of example of formulations
Second azoles mite nitrile 10%, mono-amitraz hydrochloride 5%, naphthalene sulfonic acid-formaldehyde condensation product（Dispersant）3%th, spaonin powder（Wetting agent）3%th, it is recessed Convex stick soil adds to 100%, and 15% second azoles mite nitrile mono-amitraz hydrochloride wettable powder is made.
Water dispersible granules（Example of formulations 3 ~ 4）
When above-described Pesticidal combination is water dispersible granules, following component is included in preparation：Second azoles mite nitrile 1% ~ 40%, Dan Jia Amidine hydrochloride 1% ~ 40%, dispersant 3% ~ 9%, wetting agent 1% ~ 8%, disintegrant 1% ~ 10%, filler supplement surplus.
The specific procedure of processing of Pesticidal combination water dispersible granules is：According to formula by active constituent second azoles mite nitrile, activity Ingredient mono-amitraz hydrochloride, dispersant, wetting agent, disintegrant, filler are uniformly mixed, and are crushed with micro jet, through pinching It closes, then adds in fluidized-bed granulation dryer after being granulated, drying, sieve, you can moisture of the present invention is made and dissipates Granula.
3 24% second azoles mite nitrile mono-amitraz hydrochloride water dispersible granules of example of formulations
Second azoles mite nitrile 8%, mono-amitraz hydrochloride 16%, ester APEO（Dispersant）7%th, lauryl sodium sulfate（Wetting agent） 3%th, succinic acid（Disintegrant）3%th, white carbon adds to 100%, and 20% second azoles mite nitrile mono-amitraz hydrochloride water dispersible granules are made.
4 30% second azoles mite nitrile mono-amitraz hydrochloride water dispersible granules of example of formulations
Second azoles mite nitrile 5%, mono-amitraz hydrochloride 25%, alkyl benzene sulfonate calcium salt（Dispersant）9%th, spaonin powder（Wetting agent）5%th, sulphur Sour ammonium（Disintegrant）4%th, kaolin adds to 100%, and 30% second azoles mite nitrile mono-amitraz hydrochloride water dispersible granules are made.
Suspending agent（Example of formulations 5 ~ 6）
When above-described Pesticidal combination is suspending agent, following component is included in preparation：Second azoles mite nitrile 0.1% ~ 50%, single carbonamidine Hydrochloride 0.1% ~ 50%, dispersant 2% ~ 10%, wetting agent 2% ~ 10%, antifoaming agent 0.1% ~ 1%, thickener 0.1% ~ 2%, antifreezing agent 0.1% ~ 8%, deionized water adds to 100%.
The specific procedure of processing of Pesticidal combination suspending agent is：According to formula by dispersant, wetting agent, antifoaming agent, thickening Agent, antifreezing agent are uniformly mixed by high speed shear, add active constituent second azoles mite nitrile, active constituent mono-amitraz hydrochloride, Ball milling 2 ~ 3 hours in ball mill make diameter of particle all at 5 μm hereinafter, can be made into suspending agent of the present invention.
5 20% second azoles mite nitrile mono-amitraz hydrochloride suspending agent of example of formulations
Second azoles mite nitrile 10%, mono-amitraz hydrochloride 10%, alkylnaphthalene sulfonate（Dispersant）5%th, wetting and penetrating agent F（Wetting agent） 6%、C8~10Aliphatic alcohols（Antifoaming agent）0.7%th, hydroxymethyl cellulose（Thickener）0.6%th, ethylene glycol（Antifreezing agent）0.4%th, go from Sub- water supplies surplus, and 20% second azoles mite nitrile mono-amitraz hydrochloride suspending agent is made.
6 11% second azoles mite nitrile mono-amitraz hydrochloride suspending agent of example of formulations
Second azoles mite nitrile 10%, mono-amitraz hydrochloride 1%, octylphenol polyethylene oxyethylene group ether sulfate（Dispersant）3%th, detergent alkylate Sodium sulfonate（Wetting agent）4%、C10~20Saturated fat acids（Antifoaming agent）0.2%th, xanthans（Thickener）0.4%th, polyethylene glycol（It is anti- Freeze agent）0.3%th, deionized water supplies surplus, and 11% second azoles mite nitrile mono-amitraz hydrochloride suspending agent is made.
Suspension emulsion（Example of formulations 7 ~ 8）
When above-described Pesticidal combination is suspension emulsion, following component is included in preparation：Second azoles mite nitrile 0.1% ~ 50%, single carbonamidine Hydrochloride 0.1% ~ 50%, emulsifier 2% ~ 12%, dispersant 2% ~ 10%, antifoaming agent 0.1% ~ 2%, thickener 0.1% ~ 2%, antifreezing agent 0.1% ~ 8%, preservative 0.05% ~ 3%, deionized water add to 100%.
The specific procedure of processing of the pesticide suspoemulsion is：Dispersant, antifoaming agent, thickener, antifreezing agent are passed through according to formula It crosses high speed shear-mixed and is uniformly added into active constituent second azoles mite nitrile, ball milling 2 ~ 3 hours, make diameter of particle all exist in the ball mill 5 μm hereinafter, be made second azoles mite nitrile suspending agent, then by active constituent mono-amitraz hydrochloride, emulsifier and various auxiliary agents at a high speed Blender is directly emulsified into suspending agent, you can suspension emulsion of the present invention is made.
7 15% second azoles mite nitrile mono-amitraz hydrochloride suspension emulsion of example of formulations
Second azoles mite nitrile 5%, mono-amitraz hydrochloride 10%, triethanolamine salt（Emulsifier）4%th, alkyl phenol polyoxyethylene ether formaldehyde condensation Object sulfate（Dispersant）7%th, silicone oil（Antifoaming agent）0.4%th, polyvinyl alcohol（Thickener）0.5%th, propylene glycol（Antifreezing agent）0.3%、 Sodium benzoate（Preservative）0.2%th, deionized water adds to 100%, and 15% second azoles mite nitrile mono-amitraz hydrochloride suspension emulsion is made.
8 11% second azoles mite nitrile mono-amitraz hydrochloride suspension emulsion of example of formulations
Second azoles mite nitrile 1%, mono-amitraz hydrochloride 10%, styrene polyoxyethylene ether ammonium sulfate salt（Emulsifier）3%th, aliphatic acid polyoxy Vinyl acetate（Dispersant）5%、C10~20Saturated fat acids（Antifoaming agent）0.2%th, hydroxyethyl cellulose（Thickener）0.3%th, glycerine （Antifreezing agent）0.2%th, sodium Diacetate（Preservative）0.1%th, deionized water adds to 100%, and 11% second azoles mite nitrile list carbonamidine hydrochloric acid is made Salt suspension emulsion.
Implementation of an application example two：The Toxicity Determination experiment of second azoles mite nitrile and mono-amitraz hydrochloride compounding
1 second azoles mite nitrile of toxicity test embodiment and mono-amitraz hydrochloride test the Toxicity Determination of Tetranychus cinnabarinus
Subjects：Tetranychus cinnabarinus
Test method：The standard method recommended with reference to FAO (Food and Agriculture Organization of the United Nation) FAO-slide infusion process carries out.The one of glass slide Two one centimetre of wide adhesive tapes are sticked at end, the female worm back of the body into mite are gently attached on adhesive tape, every 30 viscous, places 3-4 hours It is checked under binocular anatomical lens afterwards, rejects abnormal and dead individuals.Into the liquid 5s is soaked in one end that glass slide is stained with to examination mite, Blot liquid extra around polypide after taking-up with filter paper item rapidly.At 27 DEG C, check afterwards for 24 hours the female death toll into mite and Survival number is touched with small writing brush and determines its life or death into mite foot or mouthpart.
According to survey data, the corrected mortality of each processing is calculated, and the co-toxicity coefficient of mixture is calculated according to the abundant methods of Sun Yun （CTC values）.Use data processing system（DPS）Softwares is waited to be analyzed, calculate the LC of each medicament50、LC90, b values（Standard error）Deng Value and its 95% confidence limit.
The death rate（%）=death mite number（Head）The total mite number of/processing（Head）×100%
Corrected mortality=（Handle the death rate-blank control death rate）/（The 100- blank control death rates）×100%
Survey toxicity index（ATI）=standard agent LC50/ reagent agent LC50×100
Mixture theoretical toxicity index（TTI）=medicament A toxicity indexes × A medicaments percentage shared in mixture（%）+ medicament B Toxicity index × B medicaments percentage shared in mixture（%）
Co-toxicity coefficient（CTC）=mixture surveys toxicity index（ATI）/ mixture theoretical toxicity index（TTI）×100
Co-toxicity coefficient CTC >=120 of complex preparation show as synergistic effect, and 80 ＜ CTC ＜ 120 show as summation action, and CTC≤ 80 show as antagonism.Toxicity Determination result of the test refers to table 1.
The above test results show that active constituent second azoles mite nitrile and active constituent mono-amitraz hydrochloride compounding prevention cinnabar leaf Mite is matched 50:1~1:When between 50, co-toxicity coefficient has synergistic effect all more than 120；And 5:1~1:When between 5, Co-toxicity coefficient is above 170, and synergistic effect becomes apparent from.
2 second azoles mite nitrile of toxicity test embodiment and mono-amitraz hydrochloride test the Toxicity Determination of Tetranychus urticae
Subjects：Tetranychus urticae
Test method：The standard method recommended with reference to FAO (Food and Agriculture Organization of the United Nation) FAO-slide infusion process carries out.The one of glass slide Two one centimetre of wide adhesive tapes are sticked at end, the female worm back of the body into mite are gently attached on adhesive tape, every 30 viscous, places 3-4 hours It is checked under binocular anatomical lens afterwards, rejects abnormal and dead individuals.Into the liquid 5s is soaked in one end that glass slide is stained with to examination mite, Blot liquid extra around polypide after taking-up with filter paper item rapidly.At 27 DEG C, check afterwards for 24 hours the female death toll into mite and Survival number is touched with small writing brush and determines its life or death into mite foot or mouthpart.
According to survey data, the corrected mortality of each processing is calculated, and the co-toxicity coefficient of mixture is calculated according to the abundant methods of Sun Yun （CTC values）.Use data processing system（DPS）Softwares is waited to be analyzed, calculate the LC of each medicament50、LC90, b values（Standard error）Deng Value and its 95% confidence limit.
The death rate（%）=death mite number（Head）The total mite number of/processing（Head）×100%
Corrected mortality=（Handle the death rate-blank control death rate）/（The 100- blank control death rates）×100%
Survey toxicity index（ATI）=standard agent LC50/ reagent agent LC50×100
Mixture theoretical toxicity index（TTI）=medicament A toxicity indexes × A medicaments percentage shared in mixture（%）+ medicament B Toxicity index × B medicaments percentage shared in mixture（%）
Co-toxicity coefficient（CTC）=mixture surveys toxicity index（ATI）/ mixture theoretical toxicity index（TTI）×100
Co-toxicity coefficient CTC >=120 of complex preparation show as synergistic effect, and 80 ＜ CTC ＜ 120 show as summation action, and CTC≤ 80 show as antagonism.Toxicity Determination result of the test refers to table 2.
The above test results show that active constituent second azoles mite nitrile and active constituent mono-amitraz hydrochloride compounding two variegated leafs of prevention Mite is matched 50:1~1:When between 50, co-toxicity coefficient has synergistic effect all more than 120；And 5:1~1:When between 5, Co-toxicity coefficient is above 170, and synergistic effect becomes apparent from.
3 second azoles mite nitrile of toxicity test embodiment and mono-amitraz hydrochloride test the Toxicity Determination of Panonychus citri
Subjects：Panonychus citri
Test method：The standard method recommended with reference to FAO (Food and Agriculture Organization of the United Nation) FAO-slide infusion process carries out.The one of glass slide Two one centimetre of wide adhesive tapes are sticked at end, the female worm back of the body into mite are gently attached on adhesive tape, every 30 viscous, places 3-4 hours It is checked under binocular anatomical lens afterwards, rejects abnormal and dead individuals.Into the liquid 5s is soaked in one end that glass slide is stained with to examination mite, Blot liquid extra around polypide after taking-up with filter paper item rapidly.At 27 DEG C, check afterwards for 24 hours the female death toll into mite and Survival number is touched with small writing brush and determines its life or death into mite foot or mouthpart.
According to survey data, the corrected mortality of each processing is calculated, and the co-toxicity coefficient of mixture is calculated according to the abundant methods of Sun Yun （CTC values）.Use data processing system（DPS）Softwares is waited to be analyzed, calculate the LC of each medicament50、LC90, b values（Standard error）Deng Value and its 95% confidence limit.
The death rate（%）=death mite number（Head）The total mite number of/processing（Head）×100%
Corrected mortality=（Handle the death rate-blank control death rate）/（The 100- blank control death rates）×100%
Survey toxicity index（ATI）=standard agent LC50/ reagent agent LC50×100
Mixture theoretical toxicity index（TTI）=medicament A toxicity indexes × A medicaments percentage shared in mixture（%）+ medicament B Toxicity index × B medicaments percentage shared in mixture（%）
Co-toxicity coefficient（CTC）=mixture surveys toxicity index（ATI）/ mixture theoretical toxicity index（TTI）×100
Co-toxicity coefficient CTC >=120 of complex preparation show as synergistic effect, and 80 ＜ CTC ＜ 120 show as summation action, and CTC≤ 80 show as antagonism.Toxicity Determination result of the test refers to table 3.
The above test results show that active constituent second azoles mite nitrile and active constituent mono-amitraz hydrochloride compounding prevent full pawl Mite is matched 50:1~1:When between 50, co-toxicity coefficient has synergistic effect all more than 120；And 5:1~1:When between 5, Co-toxicity coefficient is above 170, and synergistic effect becomes apparent from.
Implementation of an application example three：Second azoles mite nitrile and the field control effectiveness test of mono-amitraz hydrochloride compounding
Field information embodiment 1 prevents the field control effectiveness test of citrus/red spider
Reference《Pesticide field efficacy medicine test criterion（One）Acaricide prevention panonychus citri GB/T 17980.11-2000》, examination Medicament, comparison medicament and the processing of the cell of blank control are tested using random alignment, per 2 plants of citruses of cell, often handles 4 repetitions.
Investigation and statistical method：Mite mouthful radix is investigated before dispenser, 3 after dispenser, is investigated respectively within 7,14,21 days, often A cell fixes 2 plants of citruses of investigation, every plant of tree respectively from east, south, west, north and in 5 orientation fix 5 brachyplasts, investigated per the tip Work mite number on 3 leaves of top tip.
Mite mouthful decline rate（%）=（Mite number after mite number-dispenser before dispenser）Mite number × 100% before/dispenser；
Control effect（%）=（Chemicals treatment district mite mouthful decline rate-space management area mite mouthful decline rate）/（100- space managements area mite Mouth decline rate）×100%.
By table 4 it is found that 3 days after medicine, second azoles mite nitrile and the preventive effect of mono-amitraz hydrochloride complex preparation embodiment 1 ~ 8 are 70.75% ~ 79.15%, 30% second azoles mite nitrile suspending agent preventive effect of comparison medicament is 61.52%, 25% mono-amitraz hydrochloride water of comparison medicament The preventive effect of agent is 66.31%, and the preventive effect of embodiment 1 ~ 8 is apparently higher than comparison medicament single dose.
7 days after medicine, the preventive effect of second azoles mite nitrile and mono-amitraz hydrochloride complex preparation embodiment 1 ~ 8 is 79.35% ~ 86.24%, 30% second azoles mite nitrile suspending agent preventive effect of comparison medicament is 73.04%, and the preventive effect of 25% aqueous single formamidine muriate agent of comparison medicament is 75.92%, the preventive effect of embodiment 1 ~ 8 is apparently higher than comparison medicament single dose.
14 days after medicine, the preventive effect of second azoles mite nitrile and mono-amitraz hydrochloride complex preparation embodiment 1 ~ 8 for 89.11% ~ 97.48%, 30% second azoles mite nitrile suspending agent preventive effect of comparison medicament is 81.15%, and 25% aqueous single formamidine muriate agent of comparison medicament is prevented It is 65.69% to imitate, and the preventive effect of embodiment 1 ~ 8 is apparently higher than comparison medicament single dose.
21 days after medicine, the preventive effect of second azoles mite nitrile and mono-amitraz hydrochloride complex preparation embodiment 1 ~ 8 for 76.24% ~ 85.56%, 30% second azoles mite nitrile suspending agent preventive effect of comparison medicament is 70.63%, and 25% aqueous single formamidine muriate agent of comparison medicament is prevented It is 59.34% to imitate, and the preventive effect of embodiment 1 ~ 8 is apparently higher than comparison medicament single dose.
During dispenser, poisoning generation is found no, to crop safety.
Field information embodiment 2 prevents the field control effectiveness test of lichee/tetranychid
Reference《Pesticide field efficacy medicine test criterion（One）Acaricide prevention panonychus citri GB/T 17980.11-2000》, examination Medicament, comparison medicament and the processing of the cell of blank control are tested using random alignment, per 2 plants of litchis of cell, often handles 4 weights It is multiple.Liquid is uniformly sprayed on to blade tow sides, is advisable with squirting blade and not dripped to liquid.Blank district sprays the clear of equivalent Water.
2 plants of litchis of investigation are fixed per cell, East, West, South, North, in 5 orientation respectively mark the blade 3 of same tip phase Piece, each cell investigate the movable mite quantity on 30 blades.The investigation of mite mouthful radix is carried out before dispenser, 3 after dispenser, 7,14, Respectively investigation 1 time in 21 days, records mite number living.
Mite mouthful decline rate（%）=（Mite number after mite number-dispenser before dispenser）Mite number × 100% before/dispenser；
Control effect（%）=（Chemicals treatment district mite mouthful decline rate-space management area mite mouthful decline rate）/（100- space managements area mite Mouth decline rate）×100%.
By table 5 it is found that 3 days after medicine, second azoles mite nitrile and the preventive effect of mono-amitraz hydrochloride complex preparation embodiment 1 ~ 8 are 75.13% ~ 82.27%, 30% second azoles mite nitrile suspending agent preventive effect of comparison medicament is 63.48%, 25% mono-amitraz hydrochloride water of comparison medicament The preventive effect of agent is 68.29%, and the preventive effect of embodiment 1 ~ 8 is apparently higher than comparison medicament single dose.
7 days after medicine, the preventive effect of second azoles mite nitrile and mono-amitraz hydrochloride complex preparation embodiment 1 ~ 8 is 83.91% ~ 89.44%, 30% second azoles mite nitrile suspending agent preventive effect of comparison medicament is 76.28%, and the preventive effect of 25% aqueous single formamidine muriate agent of comparison medicament is 78.43%, the preventive effect of embodiment 1 ~ 8 is apparently higher than comparison medicament single dose.
14 days after medicine, the preventive effect of second azoles mite nitrile and mono-amitraz hydrochloride complex preparation embodiment 1 ~ 8 for 91.25% ~ 98.35%, 30% second azoles mite nitrile suspending agent preventive effect of comparison medicament is 80.04%, and 25% aqueous single formamidine muriate agent of comparison medicament is prevented It is 66.78% to imitate, and the preventive effect of embodiment 1 ~ 8 is apparently higher than comparison medicament single dose.
21 days after medicine, the preventive effect of second azoles mite nitrile and mono-amitraz hydrochloride complex preparation embodiment 1 ~ 8 for 78.03% ~ 87.42%, 30% second azoles mite nitrile suspending agent preventive effect of comparison medicament is 69.37%, and 25% aqueous single formamidine muriate agent of comparison medicament is prevented It is 60.26% to imitate, and the preventive effect of embodiment 1 ~ 8 is apparently higher than comparison medicament single dose.
During dispenser, poisoning generation is found no, to crop safety.
In conclusion Pesticidal combination second azoles mite nitrile of the present invention is compounded with mono-amitraz hydrochloride, to citrus/red spider Spider, lichee/tetranychid have a significant synergistic effect, expand insecticidal spectrum, can delaying drug resistance, to crop safety, medication can be reduced Amount, it is environmentally safe.

Claims (5)

1. the Pesticidal combination of the mite nitrile of azoles containing second and mono-amitraz hydrochloride, it is characterised in that：The Pesticidal combination is containing active Ingredient second azoles mite nitrile and active constituent mono-amitraz hydrochloride, the mass ratio of the two is 50:1~1:50.
2. Pesticidal combination according to claim 1, it is characterised in that：Active constituent second azoles mite nitrile and active constituent list first Amidine hydrochloride, the mass ratio of the two is preferably 5:1~1:5.
3. Pesticidal combination according to any one of claim 1 to 2, it is characterised in that：It is living in the Pesticidal combination Property ingredient gross mass percentage composition be 10% ~ 80%.
4. Pesticidal combination according to any one of claim 1 to 3, it is characterised in that：Wettable powder, water-dispersible grain Agent, suspending agent, suspension emulsion.
5. Pesticidal combination according to claim 4, for preventing and kill off acarina pest and homoptera pest, especially to mandarin orange Tangerine/red spider, the prevention of lichee/tetranychid.
CN201810111543.9A 2018-02-05 2018-02-05 The Pesticidal combination of the mite nitrile of azoles containing second and mono-amitraz hydrochloride Pending CN108124880A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104663705A (en) * 2013-11-26 2015-06-03 中国中化股份有限公司 Pest-killing and mite-killing composition
US20170158598A1 (en) * 2012-12-19 2017-06-08 Dow Agrosciences Llc Pesticidal compositions and processes related thereto

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170158598A1 (en) * 2012-12-19 2017-06-08 Dow Agrosciences Llc Pesticidal compositions and processes related thereto
CN104663705A (en) * 2013-11-26 2015-06-03 中国中化股份有限公司 Pest-killing and mite-killing composition

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
屠予钦: "《农药科学使用指南》", 31 January 2000, 金盾出版社 *

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Application publication date: 20180608