CN108174854A - The Pesticidal combination of the mite nitrile of azoles containing second and single carbonamidine - Google Patents

The Pesticidal combination of the mite nitrile of azoles containing second and single carbonamidine Download PDF

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CN108174854A
CN108174854A CN201810110296.0A CN201810110296A CN108174854A CN 108174854 A CN108174854 A CN 108174854A CN 201810110296 A CN201810110296 A CN 201810110296A CN 108174854 A CN108174854 A CN 108174854A
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pesticidal combination
carbonamidine
mite
azoles
mite nitrile
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陈炳旭
池艳艳
冯日碧
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Plant Protection Research Institute Guangdong Academy of Agricultural Sciences
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Plant Protection Research Institute Guangdong Academy of Agricultural Sciences
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/52—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing groups, e.g. carboxylic acid amidines

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The present invention relates to pesticide fields, disclose a kind of Pesticidal combination, and active constituent is second azoles mite nitrile and single carbonamidine, and the mass ratio of the two is 50:1~1:50, preferably than being 5:1~1:2.Pesticidal combination of the present invention can be made into suspending agent, wettable powder, water dispersible granules.Significant synergistic effect is shown in a certain range after two groups of active constituents compounding of the present invention, can be reduced dosage, be reduced cost；It being capable of delaying drug resistance；It is safe, environmentally friendly environmental protection.

Description

The Pesticidal combination of the mite nitrile of azoles containing second and single carbonamidine
Technical field
The invention belongs to technical field of pesticide, are related to the Pesticidal combination of the mite nitrile of azoles containing second and single carbonamidine, for preventing agriculture Crop class pest.
Background technology
Second azoles mite nitrile：CA accession number is 1253429-01-4, and chemical name is（Z）-2-（4- tert-butyl-phenyls）- 2- cyanogen Base -1-（1- ethyl -3- methylpyrazole -5- bases）Vinyl -2,2-Dimethylpropionic acid ester.It is white solid, and fusing point is 92 ~ 93 DEG C, dimethylformamide, acetonitrile, acetone, methanol, ethyl acetate, dichloromethane etc. are soluble in, dissolves in petroleum ether, heptane, it is difficult It is dissolved in water.
Structural formula：
Second azoles mite nitrile is the product for changing the independent research of pesticide chemical research and development Co., Ltd in Shenyang, is using nitrile pyrrole mite ester as guideization Object is closed, the novel propylene nitrile compounds with high acaricidal activity found by structural modification.The medicament is low to mammal Poison, and to the non-target organism such as safety such as honeybee, bird, fish.It is 30% suspending agent that it, which processes dosage form, available for preventing the red spider of citrus The evil mites such as spider, apple tetranychus, cotton spider mites and vegetables tetranychid.
Single carbonamidine：English name：Semiamitraz, chemical name：N- (2,4- 3,5-dimethylphenyl)-N '-methylrnethwirnidamide, Molecular formula：C10H14N2。
Structural formula：
Single carbonamidine is also known as that medimeform, mite lice gram, mono-amitraz hydrochloride, ovum mite are double net, day ring mite is clear, mite class is net, is a kind of organic Nitrogen wide spectrum formamidine acaricide is the homologue of Amitraz.The acaricidal properties of single carbonamidine are much like with Amitraz, have to evil mite Tag, food refusal and avoidance effect, certain stomach toxicity and fumigation action are had concurrently, to all effective into mite, ovum, deutonymph.Drug effect plays slow Slowly, the lasting period is longer.
The long-time service of single insecticide so that resistance enhances, and dosage is continuously increased, and environmental pollution aggravates.Two kinds of medicaments Compounding, can effectively solve the problem that this problem.Inventor has found second by the research of a large amount of indoor biometrics and field control effectiveness test Azoles mite nitrile and single carbonamidine are combined application, and synergistic effect is apparent, can reduce dosage, and delaying drug resistance is environmentally safe.
Invention content
It is an object of the present invention to propose that a kind of synergistic effect is apparent, it being capable of delaying drug resistance, the desinsection group of reduction usage amount Close object.
To solve the above-mentioned problems, the technical solution adopted in the present invention is：
The Pesticidal combination of the mite nitrile of azoles containing second proposed by the present invention and single carbonamidine, it is characterised in that：The Pesticidal combination contains Active constituent second azoles mite nitrile and active constituent list carbonamidine.
The Pesticidal combination contains active constituent second azoles mite nitrile and active constituent list carbonamidine, and the mass ratio of the two is 50:1 ~1:50, the mass ratio of the two is preferably 5:1~1:2.
The Pesticidal combination, it is characterised in that：The gross mass percentage composition of active constituent in the Pesticidal combination It is 10% ~ 80%.
The Pesticidal combination can be processed into the arbitrary dosage form agriculturally allowed, wherein more preferably dosage form has suspension Agent, wettable powder, water dispersible granules.
Of the present invention dose can be prepared as the method well known to those skilled in the art.Wherein, it prepares above each Wetting agent, dispersant, disintegrant, antifoaming agent, thickener, antifreezing agent, filler used in kind preparation are those skilled in the art It is well known.
The wetting agent is selected from：Lauryl sodium sulfate, neopelex, pull open powder X, wetting and penetrating agent F, It is one or more in spaonin powder, silkworm excrement, spaonin powder.
The dispersant is selected from：It is alkylnaphthalene sulfonate, double（Alkyl）Naphthalenesulfonate formaldehyde condensation compound, naphthalenesulfonateformaldehyde formaldehyde contracting Close object, aryl phenol polyoxyethylene succinate sulfonate, octylphenol polyethylene oxyethylene group ether sulfate, polycarboxylate, sulfomethylated lignin Hydrochlorate, to methoxyl group fatty acyl anilinesulfonic acid, APES formaldehyde condensation products sulfat, alkyl benzene calcium sulfonate Salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkyl phenol polyoxyethylene ether, aliphatic amine polyoxyethylene ether, polyoxyethylene carboxylate, ester It is one or more in polyoxyethylene ether.
The disintegrant is selected from：In bentonite, ammonium sulfate, citric acid, urea, aluminium chloride, succinic acid, sodium bicarbonate It is one or more.
The antifoaming agent is selected from：C8~10Aliphatic alcohols, C10~20Saturated fat acids（Such as capric acid）And amide, silicone oil, have It is one or more in machine silicone compound.
The thickener is selected from：Xanthans, hydroxymethyl cellulose, hydroxyethyl cellulose, methylcellulose, magnesium silicate It is one or more in aluminium, polyvinyl alcohol.
The antifreezing agent is selected from：It is one or more in ethylene glycol, propylene glycol, glycerine, polyethylene glycol.
The filler is selected from：In kaolin, diatomite, bentonite, attapulgite, white carbon, starch, precipitated calcium carbonate It is one or more.
The Pesticidal combination, for preventing and kill off acarina pest and homoptera pest, especially to citrus/red spider, The prevention of lichee/tetranychid.
The advantage of the invention is that：The two compounds, and shows significant synergistic effect in a certain range, can reduce use Dose reduces cost；It being capable of delaying drug resistance；It is safe, environmentally friendly environmental protection.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, present invention specific examples below It illustrates, but the present invention is limited to absolutely not this.Percentage in embodiment is weight percentage.
Implementation of an application example one：Second azoles mite nitrile and single carbonamidine compound product example of formulations（Following content is hundred percentages of folding Content）, but the present invention is not limited to the proportional region in following embodiment.
The mass ratio that second azoles mite nitrile and single carbonamidine are formed is 50:1~1:50.Total matter of active ingredient in usual composition It is 10% ~ 80%, preferably 10% ~ 60% to measure percentage composition.According to different preparation types, active constituent content range is not Together.In general, the gross mass of solid pharmaceutical preparation active ingredient is 10% ~ 80%, preferably 10% ~ 60%；Liquid preparation active ingredient Gross mass is 10% ~ 50%, preferably 10% ~ 40%.
Pesticidal combination of the present invention can be processed into the arbitrary dosage form agriculturally allowed, wherein more preferably dosage form There are suspending agent, wettable powder, water dispersible granules.
Suspending agent（Example of formulations 1 ~ 2）
When above-described Pesticidal combination is suspending agent, following component is included in preparation：Second azoles mite nitrile 0.1% ~ 50%, single carbonamidine 0.1% ~ 50%, dispersant 2% ~ 10%, wetting agent 2% ~ 10%, antifoaming agent 0.1% ~ 1%, thickener 0.1% ~ 2%, antifreezing agent 0.1% ~ 8%, Deionized water adds to 100%.
The specific procedure of processing of Pesticidal combination suspending agent is：According to formula by dispersant, wetting agent, antifoaming agent, thickening Agent, antifreezing agent are uniformly mixed by high speed shear, active constituent second azoles mite nitrile, active constituent list carbonamidine are added, in ball mill Middle ball milling 2 ~ 3 hours makes diameter of particle all at 5 μm hereinafter, can be made into suspending agent of the present invention.
1 30% second azoles mite nitrile list carbonamidine suspending agent of example of formulations
Second azoles mite nitrile 25%, single carbonamidine 5%, lignosulfonates（Dispersant）7%th, silkworm excrement（Wetting agent）5%、C8~10Aliphatic alcohols （Antifoaming agent）0.6%th, polyvinyl alcohol（Thickener）0.4%th, polyvinyl alcohol（Antifreezing agent）0.7%th, deionized water supplies surplus, is made 30% second azoles mite nitrile list carbonamidine suspending agent.
2 15% second azoles mite nitrile list carbonamidine suspending agent of example of formulations
Second azoles mite nitrile 10%, single carbonamidine 5%, to methoxyl group fatty acyl anilinesulfonic acid（Dispersant）3%th, spaonin powder（Wetting agent） 4%、C10~20Saturated fat acids（Antifoaming agent）0.5%th, aluminium-magnesium silicate（Thickener）0.2%th, aluminium-magnesium silicate（Antifreezing agent）0.2%th, it goes Ionized water supplies surplus, and 15% second azoles mite nitrile list carbonamidine suspending agent is made.
Wettable powder（Example of formulations 3 ~ 4）
When above-described Pesticidal combination is wettable powder, following component is included in preparation：Second azoles mite nitrile 1% ~ 40%, Dan Jia Amidine 1% ~ 40%, dispersant 2% ~ 10%, wetting agent 2% ~ 8%, filler supplement surplus.
The specific procedure of processing of Pesticidal combination wettable powder is：According to formula by active constituent second azoles mite nitrile, activity Ingredient list carbonamidine, dispersant, wetting agent, filler mixing, are uniformly mixed in mixed cylinder, are remixed after airslide disintegrating mill crushes Uniformly, you can wettable powder of the present invention is made.
3 20% second azoles mite nitrile list carbonamidine wettable powder of example of formulations
Second azoles mite nitrile 10%, single carbonamidine 10%, polycarboxylate（Dispersant）8%th, wetting and penetrating agent F（Wetting agent）4%th, white carbon adds to 100%, 20% second azoles mite nitrile list carbonamidine wettable powder is made.
4 15% second azoles mite nitrile list carbonamidine wettable powder of example of formulations
Second azoles mite nitrile 5%, single carbonamidine 10%, octylphenol polyethylene oxyethylene group ether sulfate（Dispersant）4%th, pull open powder X（Wetting agent） 3%th, attapulgite adds to 100%, and 15% second azoles mite nitrile list carbonamidine wettable powder is made.
Water dispersible granules（Example of formulations 5 ~ 6）
When above-described Pesticidal combination is water dispersible granules, following component is included in preparation：Second azoles mite nitrile 1% ~ 40%, Dan Jia Amidine 1% ~ 40%, dispersant 3% ~ 9%, wetting agent 1% ~ 8%, disintegrant 1% ~ 10%, filler supplement surplus.
The specific procedure of processing of Pesticidal combination water dispersible granules is：According to formula by active constituent second azoles mite nitrile, activity Ingredient list carbonamidine, dispersant, wetting agent, disintegrant, filler are uniformly mixed, and are crushed with micro jet, through mediating, then It adds in fluidized-bed granulation dryer after being granulated, drying, sieve, you can water dispersible granules of the present invention are made.
5 30% second azoles mite nitrile list carbonamidine water dispersible granules of example of formulations
Second azoles mite nitrile 5%, single carbonamidine 25%, aryl phenol polyoxyethylene succinate sulfonate（Dispersant）8%th, detergent alkylate sulphur Sour sodium（Wetting agent）6%th, succinic acid（Disintegrant）5%th, bentonite adds to 100%, and 30% second azoles mite nitrile list carbonamidine water-dispersible grain is made Agent.
6 11% second azoles mite nitrile list carbonamidine water dispersible granules of example of formulations
Second azoles mite nitrile 1%, single carbonamidine 10%, naphthalene sulfonic acid-formaldehyde condensation product（Dispersant）3%th, lauryl sodium sulfate（Wetting agent）4%、 Aluminium chloride（Disintegrant）3%th, diatomite adds to 100%, and 11% second azoles mite nitrile list carbonamidine water dispersible granules are made.
Implementation of an application example two：The Toxicity Determination experiment of second azoles mite nitrile and single carbonamidine compounding
1 second azoles mite nitrile of toxicity test embodiment and single carbonamidine test the Toxicity Determination of Panonychus citri
Subjects：Panonychus citri
Test method：The standard method recommended with reference to FAO (Food and Agriculture Organization of the United Nation) FAO-slide infusion process carries out.The one of glass slide Two one centimetre of wide adhesive tapes are sticked at end, the female worm back of the body into mite are gently attached on adhesive tape, every 30 viscous, places 3-4 hours It is checked under binocular anatomical lens afterwards, rejects abnormal and dead individuals.Into the liquid 5s is soaked in one end that glass slide is stained with to examination mite, Blot liquid extra around polypide after taking-up with filter paper item rapidly.At 27 DEG C, check afterwards for 24 hours the female death toll into mite and Survival number is touched with small writing brush and determines its life or death into mite foot or mouthpart.
According to survey data, the corrected mortality of each processing is calculated, and the co-toxicity coefficient of mixture is calculated according to the abundant methods of Sun Yun （CTC values）.Use data processing system（DPS）Softwares is waited to be analyzed, calculate the LC of each medicament50、LC90, b values（Standard error）Deng Value and its 95% confidence limit.
The death rate（%）=death mite number（Head）The total mite number of/processing（Head）×100%
Corrected mortality=（Handle the death rate-blank control death rate）/（The 100- blank control death rates）×100%
Survey toxicity index（ATI）=standard agent LC50/ reagent agent LC50×100
Mixture theoretical toxicity index（TTI）=medicament A toxicity indexes × A medicaments percentage shared in mixture（%）+ medicament B Toxicity index × B medicaments percentage shared in mixture（%）
Co-toxicity coefficient（CTC）=mixture surveys toxicity index（ATI）/ mixture theoretical toxicity index（TTI）×100
Co-toxicity coefficient CTC >=120 of complex preparation show as synergistic effect, and 80 ＜ CTC ＜ 120 show as summation action, and CTC≤ 80 show as antagonism.Toxicity Determination result of the test refers to table 1.
The above test results show that active constituent second azoles mite nitrile and active constituent list carbonamidine compounding prevention Panonychus citri, proportioning 50:1~1:When between 50, co-toxicity coefficient has synergistic effect all more than 120；And 5:1~1:When between 2, co-toxicity coefficient 190 are above, synergistic effect becomes apparent from.
2 second azoles mite nitrile of toxicity test embodiment and single carbonamidine test the Toxicity Determination of Tetranychus cinnabarinus
Subjects：Tetranychus cinnabarinus
Test method：The standard method recommended with reference to FAO (Food and Agriculture Organization of the United Nation) FAO-slide infusion process carries out.The one of glass slide Two one centimetre of wide adhesive tapes are sticked at end, the female worm back of the body into mite are gently attached on adhesive tape, every 30 viscous, places 3-4 hours It is checked under binocular anatomical lens afterwards, rejects abnormal and dead individuals.Into the liquid 5s is soaked in one end that glass slide is stained with to examination mite, Blot liquid extra around polypide after taking-up with filter paper item rapidly.At 27 DEG C, check afterwards for 24 hours the female death toll into mite and Survival number is touched with small writing brush and determines its life or death into mite foot or mouthpart.
According to survey data, the corrected mortality of each processing is calculated, and the co-toxicity coefficient of mixture is calculated according to the abundant methods of Sun Yun （CTC values）.Use data processing system（DPS）Softwares is waited to be analyzed, calculate the LC of each medicament50、LC90, b values（Standard error）Deng Value and its 95% confidence limit.
The death rate（%）=death mite number（Head）The total mite number of/processing（Head）×100%
Corrected mortality=（Handle the death rate-blank control death rate）/（The 100- blank control death rates）×100%
Survey toxicity index（ATI）=standard agent LC50/ reagent agent LC50×100
Mixture theoretical toxicity index（TTI）=medicament A toxicity indexes × A medicaments percentage shared in mixture（%）+ medicament B Toxicity index × B medicaments percentage shared in mixture（%）
Co-toxicity coefficient（CTC）=mixture surveys toxicity index（ATI）/ mixture theoretical toxicity index（TTI）×100
Co-toxicity coefficient CTC >=120 of complex preparation show as synergistic effect, and 80 ＜ CTC ＜ 120 show as summation action, and CTC≤ 80 show as antagonism.Toxicity Determination result of the test refers to table 2.
The above test results show that active constituent second azoles mite nitrile and active constituent list carbonamidine compounding prevention Tetranychus cinnabarinus, match Than 50:1~1:When between 50, co-toxicity coefficient has synergistic effect all more than 120；And 5:1~1:When between 2, poison is altogether Number is above 180, and synergistic effect becomes apparent from.
3 second azoles mite nitrile of toxicity test embodiment and single carbonamidine test the Toxicity Determination of lichee/tetranychid
Subjects：Lichee/tetranychid
Test method：The standard method recommended with reference to FAO (Food and Agriculture Organization of the United Nation) FAO-slide infusion process carries out.The one of glass slide Two one centimetre of wide adhesive tapes are sticked at end, the female worm back of the body into mite are gently attached on adhesive tape, every 30 viscous, places 3-4 hours It is checked under binocular anatomical lens afterwards, rejects abnormal and dead individuals.Into the liquid 5s is soaked in one end that glass slide is stained with to examination mite, Blot liquid extra around polypide after taking-up with filter paper item rapidly.At 27 DEG C, check afterwards for 24 hours the female death toll into mite and Survival number is touched with small writing brush and determines its life or death into mite foot or mouthpart.
According to survey data, the corrected mortality of each processing is calculated, and the co-toxicity coefficient of mixture is calculated according to the abundant methods of Sun Yun （CTC values）.Use data processing system（DPS）Softwares is waited to be analyzed, calculate the LC of each medicament50、LC90, b values（Standard error）Deng Value and its 95% confidence limit.
The death rate（%）=death mite number（Head）The total mite number of/processing（Head）×100%
Corrected mortality=（Handle the death rate-blank control death rate）/（The 100- blank control death rates）×100%
Survey toxicity index（ATI）=standard agent LC50/ reagent agent LC50×100
Mixture theoretical toxicity index（TTI）=medicament A toxicity indexes × A medicaments percentage shared in mixture（%）+ medicament B Toxicity index × B medicaments percentage shared in mixture（%）
Co-toxicity coefficient（CTC）=mixture surveys toxicity index（ATI）/ mixture theoretical toxicity index（TTI）×100
Co-toxicity coefficient CTC >=120 of complex preparation show as synergistic effect, and 80 ＜ CTC ＜ 120 show as summation action, and CTC≤ 80 show as antagonism.Toxicity Determination result of the test refers to table 3.
The above test results show that active constituent second azoles mite nitrile and active constituent list carbonamidine compounding prevention lichee/tetranychid, match Than 50:1~1:When between 50, co-toxicity coefficient has synergistic effect all more than 120；And 5:1~1:When between 2, poison is altogether Number is above 190, and synergistic effect becomes apparent from.
Implementation of an application example three：Second azoles mite nitrile and the field control effectiveness test of single carbonamidine compounding
Field information embodiment 1 prevents the field control effectiveness test of citrus/red spider
Reference《Pesticide field efficacy medicine test criterion（One）Acaricide prevention panonychus citri GB/T 17980.11-2000》, examination Medicament, comparison medicament and the processing of the cell of blank control are tested using random alignment, per 2 plants of citruses of cell, often handles 4 repetitions.
Investigation and statistical method：Mite mouthful radix is investigated before dispenser, 3 after dispenser, is investigated respectively within 7,14,21 days, often A cell fixes 2 plants of citruses of investigation, every plant of tree respectively from east, south, west, north and in 5 orientation fix 5 brachyplasts, investigated per the tip Work mite number on 3 leaves of top tip.
Mite mouthful decline rate（%）=（Mite number after mite number-dispenser before dispenser）Mite number × 100% before/dispenser；
Control effect（%）=（Chemicals treatment district mite mouthful decline rate-space management area mite mouthful decline rate）/（100- space managements area mite Mouth decline rate）×100%.
By table 4 it is found that 3 days after medicine, the preventive effect of second azoles mite nitrile and single carbonamidine complex preparation embodiment 1 ~ 6 for 70.28% ~ 78.37%, 30% second azoles mite nitrile suspending agent preventive effect of comparison medicament is 60.52%, and the preventive effect of the single carbonamidine aqua of comparison medicament 25% is 64.37%, the preventive effect of embodiment 1 ~ 6 is apparently higher than comparison medicament single dose.
7 days after medicine, second azoles mite nitrile and the preventive effect of single carbonamidine complex preparation embodiment 1 ~ 6 are 82.59% ~ 88.42%, comparison medicine 30% second azoles mite nitrile suspending agent preventive effect of agent is 70.02%, and the preventive effect of the single carbonamidine aqua of comparison medicament 25% is 74.69%, embodiment 1 ~ 6 Preventive effect be apparently higher than comparison medicament single dose.
14 days after medicine, second azoles mite nitrile and the preventive effect of single carbonamidine complex preparation embodiment 1 ~ 6 are 87.87% ~ 95.48%, control 30% second azoles mite nitrile suspending agent preventive effect of medicament is 79.15%, and the preventive effect of the single carbonamidine aqua of comparison medicament 25% is 68.52%, embodiment 1 ~ 6 preventive effect is apparently higher than comparison medicament single dose.
21 days after medicine, second azoles mite nitrile and the preventive effect of single carbonamidine complex preparation embodiment 1 ~ 6 are 77.82% ~ 86.47%, control 30% second azoles mite nitrile suspending agent preventive effect of medicament is 69.53%, and the preventive effect of the single carbonamidine aqua of comparison medicament 25% is 57.87%, embodiment 1 ~ 6 preventive effect is apparently higher than comparison medicament single dose.
During dispenser, poisoning generation is found no, to crop safety.
Field information embodiment 2 prevents the field control effectiveness test of lichee/tetranychid
Reference《Pesticide field efficacy medicine test criterion（One）Acaricide prevention panonychus citri GB/T 17980.11-2000》, examination Medicament, comparison medicament and the processing of the cell of blank control are tested using random alignment, per 2 plants of litchis of cell, often handles 4 weights It is multiple.Liquid is uniformly sprayed on to blade tow sides, is advisable with squirting blade and not dripped to liquid.Blank district sprays the clear of equivalent Water.
2 plants of litchis of investigation are fixed per cell, East, West, South, North, in 5 orientation respectively mark the blade 3 of same tip phase Piece, each cell investigate the movable mite quantity on 30 blades.The investigation of mite mouthful radix is carried out before dispenser, 3 after dispenser, 7,14, Respectively investigation 1 time in 21 days, records mite number living.
Mite mouthful decline rate（%）=（Mite number after mite number-dispenser before dispenser）Mite number × 100% before/dispenser；
Control effect（%）=（Chemicals treatment district mite mouthful decline rate-space management area mite mouthful decline rate）/（100- space managements area mite Mouth decline rate）×100%.
As shown in Table 5,3 days after medicine, the preventive effect of second azoles mite nitrile and single carbonamidine complex preparation embodiment 1 ~ 6 for 73.82% ~ 78.33%, 30% second azoles mite nitrile suspending agent preventive effect of comparison medicament is 65.59%, and the preventive effect of the single carbonamidine aqua of comparison medicament 25% is 62.69%, the preventive effect of embodiment 1 ~ 6 is apparently higher than comparison medicament single dose.
7 days after medicine, second azoles mite nitrile and the preventive effect of single carbonamidine complex preparation embodiment 1 ~ 6 are 81.87% ~ 88.67%, comparison medicine 30% second azoles mite nitrile suspending agent preventive effect of agent is 77.35%, and the preventive effect of the single carbonamidine aqua of comparison medicament 25% is 70.21%, embodiment 1 ~ 6 Preventive effect be apparently higher than comparison medicament single dose.
14 days after medicine, second azoles mite nitrile and the preventive effect of single carbonamidine complex preparation embodiment 1 ~ 6 are 90.47% ~ 96.47%, control 30% second azoles mite nitrile suspending agent preventive effect of medicament is 80.51%, and the preventive effect of the single carbonamidine aqua of comparison medicament 25% is 61.45%, embodiment 1 ~ 6 preventive effect is apparently higher than comparison medicament single dose.
21 days after medicine, second azoles mite nitrile and the preventive effect of single carbonamidine complex preparation embodiment 1 ~ 6 are 78.25% ~ 85.72%, control 30% second azoles mite nitrile suspending agent preventive effect of medicament is 73.24%, and the preventive effect of the single carbonamidine aqua of comparison medicament 25% is 56.62%, embodiment 1 ~ 6 preventive effect is apparently higher than comparison medicament single dose.
During dispenser, poisoning generation is found no, to crop safety.
In conclusion Pesticidal combination second azoles mite nitrile of the present invention is compounded with single carbonamidine, to citrus/red spider, litchi Branch/tetranychid has a significant synergistic effect, expands insecticidal spectrum, can delaying drug resistance, to crop safety, dosage can be reduced, it is right Environmental security.

Claims (5)

1. the Pesticidal combination of the mite nitrile of azoles containing second and single carbonamidine, it is characterised in that：The Pesticidal combination contains active constituent second Azoles mite nitrile and active constituent list carbonamidine, the mass ratio of the two is 50:1~1:50.
2. Pesticidal combination according to claim 1, it is characterised in that：Active constituent second azoles mite nitrile and active constituent list first Amidine, the mass ratio of the two is preferably 5:1~1:2.
3. Pesticidal combination according to any one of claim 1 to 2, it is characterised in that：It is living in the Pesticidal combination Property ingredient gross mass percentage composition be 10% ~ 80%.
4. Pesticidal combination according to any one of claim 1 to 3, it is characterised in that：It can be made into suspending agent, wettable Pulvis, water dispersible granules.
5. Pesticidal combination according to claim 4, for preventing and kill off acarina pest and homoptera pest, especially to mandarin orange Tangerine/red spider, the prevention of lichee/tetranychid.
CN201810110296.0A 2018-02-05 2018-02-05 The Pesticidal combination of the mite nitrile of azoles containing second and single carbonamidine Pending CN108174854A (en)

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CN114762502A (en) * 2021-01-13 2022-07-19 沈阳中化农药化工研发有限公司 Acaricide suspending agent and preparation thereof
CN114762502B (en) * 2021-01-13 2023-03-21 沈阳中化农药化工研发有限公司 Acaricide suspending agent and preparation thereof

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