CN102084862B - Insecticidal composition containing ethiprole - Google Patents
Insecticidal composition containing ethiprole Download PDFInfo
- Publication number
- CN102084862B CN102084862B CN201110066551.4A CN201110066551A CN102084862B CN 102084862 B CN102084862 B CN 102084862B CN 201110066551 A CN201110066551 A CN 201110066551A CN 102084862 B CN102084862 B CN 102084862B
- Authority
- CN
- China
- Prior art keywords
- worm nitrile
- active ingredient
- rynaxypyr
- rice
- fipronil bisamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims abstract description 58
- 230000000749 insecticidal Effects 0.000 title claims abstract description 13
- FNELVJVBIYMIMC-UHFFFAOYSA-N Ethiprole Chemical compound N1=C(C#N)C(S(=O)CC)=C(N)N1C1=C(Cl)C=C(C(F)(F)F)C=C1Cl FNELVJVBIYMIMC-UHFFFAOYSA-N 0.000 title claims abstract description 5
- 241000607479 Yersinia pestis Species 0.000 claims abstract description 10
- 150000002825 nitriles Chemical class 0.000 claims description 86
- 239000000843 powder Substances 0.000 claims description 18
- 239000000375 suspending agent Substances 0.000 claims description 15
- 238000009736 wetting Methods 0.000 claims description 15
- 230000000361 pesticidal Effects 0.000 claims description 14
- 239000004562 water dispersible granule Substances 0.000 claims description 13
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 235000013339 cereals Nutrition 0.000 claims 1
- 235000013399 edible fruits Nutrition 0.000 claims 1
- 235000013311 vegetables Nutrition 0.000 claims 1
- ZOCSXAVNDGMNBV-UHFFFAOYSA-N Fipronil Chemical compound NC1=C(S(=O)C(F)(F)F)C(C#N)=NN1C1=C(Cl)C=C(C(F)(F)F)C=C1Cl ZOCSXAVNDGMNBV-UHFFFAOYSA-N 0.000 abstract description 33
- 239000005899 Fipronil Substances 0.000 abstract description 33
- FTQWRYSLUYAIRQ-UHFFFAOYSA-N N-[(octadecanoylamino)methyl]octadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(=O)NCNC(=O)CCCCCCCCCCCCCCCCC FTQWRYSLUYAIRQ-UHFFFAOYSA-N 0.000 abstract description 33
- 229940013764 fipronil Drugs 0.000 abstract description 33
- 239000003814 drug Substances 0.000 abstract description 19
- 241000238631 Hexapoda Species 0.000 abstract description 15
- 241000256247 Spodoptera exigua Species 0.000 abstract description 9
- 239000000575 pesticide Substances 0.000 abstract description 8
- 239000002917 insecticide Substances 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 5
- 241001249129 Scirpophaga incertulas Species 0.000 abstract description 4
- 238000001228 spectrum Methods 0.000 abstract description 3
- 241001347511 Carposina sasakii Species 0.000 abstract description 2
- 241000098289 Cnaphalocrocis medinalis Species 0.000 abstract description 2
- 241000500437 Plutella xylostella Species 0.000 abstract description 2
- 241000176086 Sogatella furcifera Species 0.000 abstract description 2
- 238000003912 environmental pollution Methods 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract 6
- 239000005886 Chlorantraniliprole Substances 0.000 abstract 1
- 241001517923 Douglasiidae Species 0.000 abstract 1
- 241000220225 Malus Species 0.000 abstract 1
- 241001481296 Malus spectabilis Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- PSOVNZZNOMJUBI-UHFFFAOYSA-N chlorantraniliprole Chemical compound CNC(=O)C1=CC(Cl)=CC(C)=C1NC(=O)C1=CC(Br)=NN1C1=NC=CC=C1Cl PSOVNZZNOMJUBI-UHFFFAOYSA-N 0.000 abstract 1
- 239000002131 composite material Substances 0.000 description 18
- -1 aryl phenol Chemical compound 0.000 description 13
- 230000002195 synergetic Effects 0.000 description 11
- 239000002270 dispersing agent Substances 0.000 description 9
- 239000000080 wetting agent Substances 0.000 description 9
- 241000209094 Oryza Species 0.000 description 7
- 235000007164 Oryza sativa Nutrition 0.000 description 7
- 235000009566 rice Nutrition 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 6
- 239000000945 filler Substances 0.000 description 6
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
- 239000011230 binding agent Substances 0.000 description 5
- 239000007859 condensation product Substances 0.000 description 5
- 239000008367 deionised water Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 231100000419 toxicity Toxicity 0.000 description 5
- 230000001988 toxicity Effects 0.000 description 5
- VSCWAEJMTAWNJL-UHFFFAOYSA-K Aluminium chloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 4
- HWKQNAWCHQMZHK-UHFFFAOYSA-N Trolnitrate Chemical compound [O-][N+](=O)OCCN(CCO[N+]([O-])=O)CCO[N+]([O-])=O HWKQNAWCHQMZHK-UHFFFAOYSA-N 0.000 description 4
- 239000003905 agrochemical Substances 0.000 description 4
- 230000002528 anti-freeze Effects 0.000 description 4
- 239000000440 bentonite Substances 0.000 description 4
- 229910000278 bentonite Inorganic materials 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 239000007884 disintegrant Substances 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 229920001296 polysiloxane Polymers 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 230000003449 preventive Effects 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 4
- 239000004094 surface-active agent Substances 0.000 description 4
- 231100000820 toxicity test Toxicity 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- PZZYQPZGQPZBDN-UHFFFAOYSA-N Aluminium silicate Chemical compound O=[Al]O[Si](=O)O[Al]=O PZZYQPZGQPZBDN-UHFFFAOYSA-N 0.000 description 3
- 239000005995 Aluminium silicate Substances 0.000 description 3
- BTCSSZJGUNDROE-UHFFFAOYSA-N GABA Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 3
- 240000003377 Shepherdia canadensis Species 0.000 description 3
- 235000018324 Shepherdia canadensis Nutrition 0.000 description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- LSNNMFCWUKXFEE-UHFFFAOYSA-L Sulphite Chemical compound [O-]S([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-L 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 235000012211 aluminium silicate Nutrition 0.000 description 3
- 229960003692 aminobutyric acid Drugs 0.000 description 3
- 229960000892 attapulgite Drugs 0.000 description 3
- 238000009833 condensation Methods 0.000 description 3
- 230000005494 condensation Effects 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 229910052625 palygorskite Inorganic materials 0.000 description 3
- 230000000149 penetrating Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2R,3R,4S,5R,6S)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2S,3R,4S,5R,6R)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2R,3R,4S,5R,6R)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 2
- DUIOKRXOKLLURE-UHFFFAOYSA-N 2-octylphenol Chemical compound CCCCCCCCC1=CC=CC=C1O DUIOKRXOKLLURE-UHFFFAOYSA-N 0.000 description 2
- GHNRTXCRBJQVGN-UHFFFAOYSA-N 4-dodecan-6-ylbenzenesulfonic acid Chemical compound CCCCCCC(CCCCC)C1=CC=C(S(O)(=O)=O)C=C1 GHNRTXCRBJQVGN-UHFFFAOYSA-N 0.000 description 2
- 244000215068 Acacia senegal Species 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N Ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 241000255789 Bombyx mori Species 0.000 description 2
- 229960005069 Calcium Drugs 0.000 description 2
- 210000003169 Central Nervous System Anatomy 0.000 description 2
- 102000011045 Chloride Channels Human genes 0.000 description 2
- 108010062745 Chloride Channels Proteins 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
- ZBCBWPMODOFKDW-UHFFFAOYSA-N Diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 2
- 229920000084 Gum arabic Polymers 0.000 description 2
- 229920001732 Lignosulfonate Polymers 0.000 description 2
- 240000007119 Malus pumila Species 0.000 description 2
- 206010067482 No adverse event Diseases 0.000 description 2
- 239000004698 Polyethylene (PE) Substances 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 239000005864 Sulphur Substances 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 239000000205 acacia gum Substances 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 230000003042 antagnostic Effects 0.000 description 2
- 230000001488 breeding Effects 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 150000007942 carboxylates Chemical class 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 238000009114 investigational therapy Methods 0.000 description 2
- 231100000636 lethal dose Toxicity 0.000 description 2
- 231100000225 lethality Toxicity 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 125000006353 oxyethylene group Chemical group 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- KFSLWBXXFJQRDL-UHFFFAOYSA-N peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 2
- 229920005646 polycarboxylate Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- SRAWNDFHGTVUNZ-UHFFFAOYSA-M sodium;3,6-dibutylnaphthalene-1-sulfonate Chemical compound [Na+].[O-]S(=O)(=O)C1=CC(CCCC)=CC2=CC(CCCC)=CC=C21 SRAWNDFHGTVUNZ-UHFFFAOYSA-M 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- 230000017613 viral reproduction Effects 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 241000255777 Lepidoptera Species 0.000 description 1
- 230000035980 PAA Effects 0.000 description 1
- 229940088417 PRECIPITATED CALCIUM CARBONATE Drugs 0.000 description 1
- 241001525802 Phyllonorycter pomonella Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229940005550 Sodium alginate Drugs 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N Triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 230000000996 additive Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive Effects 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 238000000498 ball milling Methods 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000004059 degradation Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 229940079593 drugs Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 229940013945 gamma-Aminobutyric Acid Drugs 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000002045 lasting Effects 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000005011 phenolic resin Substances 0.000 description 1
- 229920001568 phenolic resin Polymers 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 229920001888 polyacrylic acid Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 description 1
- 239000002728 pyrethroid Substances 0.000 description 1
- 235000021003 saturated fats Nutrition 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- MSXHSNHNTORCAW-UHFFFAOYSA-M sodium 3,4,5,6-tetrahydroxyoxane-2-carboxylate Chemical compound [Na+].OC1OC(C([O-])=O)C(O)C(O)C1O MSXHSNHNTORCAW-UHFFFAOYSA-M 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 239000001187 sodium carbonate Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
Abstract
The invention discloses an insecticidal composition containing ethiprole, which contains an active ingredient A and an active ingredient B, wherein the active ingredient A is selected from the ethiprole, the active ingredient B is selected from any one of following insecticides: fipronil bisamide and chlorantraniliprole, and the ratio of the active ingredient A to the active ingredient B by weight percent is 1-40%: 1-40%. The composition can be used for controlling a variety of insect pests, has obvious synergy, expands an insecticidal spectrum and has higher activity for rice fulgorid, rice-stem borer, yellow rice borer, rice leaf folder, beet armyworm, diamondback moth, apple peach fruit borer and asiatic apple leafminer; furthermore, the dosage of pesticide can be reduced, the residual quantity of the pesticide on crops can be reduced, and the environmental pollution can be also reduced; and the insecticidal composition is safe to people and animals, and good in environmental compatibility, and the insect pests are less prone to generating medicament resistance.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of Pesticidal combination that contains second worm nitrile.
Background technology
Second worm nitrile, English common name (ethiprole), molecular formula: C
13h
9cl
2f
3n
4oS, sub-sulphur (sulphur) acyl group of chemical name: 5-amino-1-(2,6-dichloro-4-fluoromethylphenyl)-4-ethyl pyrazoles-3-itrile group.Second worm nitrile is novel pyrazole insecticides, and insecticidal spectrum is wide.Disturb chloride channel by γ-aminobutyric acid (GABA), make insect lethal thereby destroy central nervous system (CNS) normal activity.This medicine is tightr to the white clothing constraint comparison vertebrate of insect GABA chloride channel.Thereby provide very high selection toxicity.Its mechanism of action is different from the main insecticide families such as pyrethroid, organic phosphor, carbamate, does not almost produce the chance of interactivity with the existing insecticide of majority.Therefore, it is the desirable standby kind of resistance management, can be with the mixed pesticide of other chemical family, be used alternatingly.
But in the real process of agricultural production, the problem that pest control the most easily produces is the generation of pest resistance to insecticide.Insect important in agricultural is if lepidoptera pest is because its breeding cycle is short, and breeding amount is large, and mobility is little, and selfing degree is high, especially easily produces resistance.
Different cultivars composition carries out composite, is the very common method of control resistant insect.Heterogeneity is carried out composite, according to practical application effect, judge certain composite be synergy, add and or antagonism.In most cases, the composite effect of agricultural chemicals is all additive effect, really have a synergistic effect composite seldom, especially synergistic effect very obviously, co-toxicity coefficient very high composite just still less.Through inventor research, find after second worm nitrile and fipronil bisamide, Rynaxypyr is composite to produce good synergistic effect, and not yet open about the composite relevant report of second worm nitrile and fipronil bisamide, Rynaxypyr.
Summary of the invention
Resistance that the long-term use of second worm nitrile single dose may bring occurs, degradation problem under drug effect, and the Pesticidal combination that the present invention proposes contains A, two kinds of active components of B, and appropriate surfactant and carrier.
A kind of Pesticidal combination that contains second worm nitrile, comprise effective active component, auxiliary agent and filler, it is characterized in that: active components A, B percentage by weight are 1～40%: 1～40%, described active components A is selected from second worm nitrile, and active component B is selected from the one in fipronil bisamide, Rynaxypyr.
Described a kind of Pesticidal combination that contains second worm nitrile, is characterized in that: the percentage by weight of A, two kinds of active components of B is 1～30%: 1～30%.
The described Pesticidal combination that contains second worm nitrile, is characterized in that: the percentage by weight of second worm nitrile and fipronil bisamide is 5～20%: 5～20%;
The described Pesticidal combination that contains second worm nitrile, is characterized in that: the percentage by weight of second worm nitrile and Rynaxypyr is 5～20%: 5～20%.
The percentage by weight of A, two kinds of active components of B is 1～40%: 1～40%.Conventionally in composition, active weight percentage is gross weight 0.5～90%, is preferably 5%～85%.According to different preparation types, active component content scope is different.Conventionally, liquid preparation contains 1～70% active substance by weight, is preferably 5～50%; Solid pharmaceutical preparation contains 5～85% active substance by weight, is preferably 10～80%.
In Pesticidal combination of the present invention, at least contain a kind of surfactant, the dispersion of active component in water while being beneficial to use.Surface-active contents is 5～30% of total formulation weight amount, and surplus is solid or liquid diluent.
The selected surfactant of Pesticidal combination of the present invention is known in those skilled in the art: can be selected from one or more in dispersant, wetting agent, binding agent or defoamer.According to different dosage form, in preparation, can also contain disintegrant known in those skilled in the art, antifreeze etc.
Described dispersant is selected from alkylnaphthalene sulfonate, two (alkyl) naphthalenesulfonate formaldehyde condensation compound, naphthalene sulfonic acid-formaldehyde condensation product, aryl phenol polyoxyethylene succinate sulfonate, octylphenol polyethylene oxyethylene group ether sulfate, polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, polyoxyethylene carboxylate, one or more during ester polyoxyethylene is phonetic.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride.
Described binding agent is selected from: one or more in gum Arabic, xanthans, sodium phosphate trimer, phenolic resins, sodium alginate, white dextrin, methylcellulose, PAA, polyvinylpyrrolidone, crospolyvinylpyrrolidone, polyethylene glycol, polyvinyl alcohol.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, polyethylene glycol.
Described defoamer is selected from: silicone, C
8～10aliphatic alcohols, C
10～20one or more in saturated fat acids (as capric acid) and acid amides, silicone oil, silicone compound.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, precipitated calcium carbonate.
Composition of the present invention can be by user before use through dilution or directly use.Its preparation can be prepared by common processing method, after mixing, then adds surfactant as one or more in dispersant, stabilizing agent, wetting agent, adhesive, defoamer etc. by active substance with liquid flux or solid carrier.
Pesticidal combination of the present invention, can be processed into acceptable formulation on any agricultural chemicals on demand.Wherein preferred dosage form is wetting powder, water dispersible granules, suspending agent.
When making wetting powder, composition comprises following constituent content: second worm nitrile 1～40%, active component B 1～40%, dispersant 5～10%, wetting agent 2～10%, filler 8～91%.
Active component second worm nitrile, active component B, dispersant, wetting agent, filler are mixed, in mixed cylinder, mix, after airslide disintegrating mill is pulverized, mix again, can be made into the wetting powder product of the present composition.
When making water dispersible granules, composition comprises following constituent content: active component second worm nitrile 1～40%, active component B 1～40%, dispersant 3～12%, wetting agent 1～8%, disintegrant 1～10%, binding agent 1～8%, filler 10～92%.
Active component second worm nitrile, active component B, dispersant, wetting agent, disintegrant, filler etc. are obtained to the particle diameter needing through air-flow crushing together, then add other auxiliary agents such as binding agent, obtain the materials of granulating.By item quantitatively send in fluidized bed granulation dryer through granulation and dry after, make the water dispersible granules product of the present composition.
When making suspending agent, composition comprises following constituent content: active component second worm nitrile 1～25%, active component B 1～25%, dispersant 2～10%, wetting agent 2～10%, defoamer 0.1～1%, binding agent 0.1～2%, antifreeze 0.1～8%, deionized water add to 100%.
Dispersant, wetting agent, defoamer, thickener, antifreeze in above-mentioned formulation material are mixed through high speed shear, add active component second worm nitrile, active component B, ball milling 2～3 hours in ball mill, make diameter of particle all below 5 μ m, make the suspending agent product of the present composition.
The invention has the advantages that: after (1) second worm nitrile and active component B are composite, there is notable synergistic and lasting effect; (2) expanded insecticidal spectrum, rice fulgorid, rice-stem borer, paddy stem borer, rice leaf roller, beet armyworm, diamond-back moth, apple peach fruit borer, apple apple leaf miner have been had to greater activity; (3) reduce the dosage of agricultural chemicals, reduced the residual quantity of agricultural chemicals on crop, alleviated environmental pollution; (4), insect good to person poultry safety, Environmental compatibility is difficult for developing immunity to drugs.
Embodiment
Below in conjunction with embodiment, to further instruction of the present invention, the percentage in embodiment is all weight percentage, but the present invention is not limited thereto.
Application Example one
Example 1 48% second worm nitrile fipronil bisamide wetting powder
Second worm nitrile 8%, fipronil bisamide 40%, lignosulfonates 7%, soapberry powder 6%, bentonite add to 100%, and mixture carries out air-flow crushing, make 48% second worm nitrile fipronil bisamide wetting powder.
Example 2 50% second worm nitrile fipronil bisamide wetting powders
Second worm nitrile 25%, fipronil bisamide 25%, alkyl benzene sulfonate calcium salt 8%, wetting and penetrating agent F 6%, diatomite add to 100%, and mixture carries out air-flow crushing, make 50% second worm nitrile fipronil bisamide wetting powder.
Example 3 40% second worm nitrile fipronil bisamide water dispersible granules
Second worm nitrile 10%, fipronil bisamide 30%, two (alkyl) naphthalenesulfonate formaldehyde condensation compound 6%, spaonin powder 4%, urea 2%, kaolin add to 100%, mix and make 40% second worm nitrile fipronil bisamide water dispersible granules.
Example 4 60% second worm nitrile fipronil bisamide water dispersible granules
Second worm nitrile 20%, fipronil bisamide 40%, alkylphenol-polyethenoxy are phonetic 8%, lauryl sodium sulfate 7%, sodium carbonate 1.8%, attapulgite add to 100%, mix and make 60% second worm nitrile fipronil bisamide water dispersible granules.
Example 5 10% second worm nitrile fipronil bisamide suspension agents
Second worm nitrile 5%, fipronil bisamide 5%, aryl phenol polyoxyethylene succinate sulfonate 7%, soapberry powder 5%, silicone compound 0.1%, polyvinylpyrrolidone 1.5%, propane diols 1.8%, deionized water add to 100%, mix and make 10% second worm nitrile fipronil bisamide suspension agent.
Example 6 30% second worm nitrile fipronil bisamide suspension agents
Second worm nitrile 20%, fipronil bisamide 10%, the phonetic formaldehyde condensation products sulphate 8% of alkylphenol-polyethenoxy, Nekal BX 6%, C
10～20saturated fat acids 0.2%, gum Arabic 1.2%, triethylene glycol 1.6%, deionized water add to 100%, mix and make 30% second worm nitrile fipronil bisamide suspension agent.
Example 7 45% second worm nitrile Rynaxypyr wetting powders
Second worm nitrile 15%, Rynaxypyr 30%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 8%, tea are withered 7%, attapulgite adds to 100%, and mixture carries out air-flow crushing, makes 45% second worm nitrile Rynaxypyr wetting powder.
Example 8 46% second worm nitrile Rynaxypyr wetting powders
Second worm nitrile 40%, Rynaxypyr 6%, polyoxyethylene carboxylate 6%, spaonin powder 5%, kaolin add to 100%, and mixture carries out air-flow crushing, make 46% second worm nitrile Rynaxypyr wetting powder.
Example 9 40% second worm nitrile Rynaxypyr water dispersible granules
Second worm nitrile 20%, Rynaxypyr 20%, polycarboxylate 7%, lauryl sodium sulfate 6%, ammonium sulfate 2.2%, bentonite add to 100%, mix and make 40% second worm nitrile Rynaxypyr water dispersible granules.
Example 10 50% second worm nitrile Rynaxypyr water dispersible granules
Second worm nitrile 10%, Rynaxypyr 40%, aliphatic amine polyoxyethylene are phonetic 6%, silkworm excrement 4%, aluminium chloride 2.5%, diatomite add to 100%, mix and make 50% second worm nitrile Rynaxypyr water dispersible granules.
Example 11 20% second worm nitrile Rynaxypyr suspending agents
Second worm nitrile 10%, Rynaxypyr 10%, octylphenol polyethylene oxyethylene group ether sulfate 6%, DBSA 5%, C
8～10aliphatic alcohols 0.5%, methylcellulose 1.4%, ethylene glycol 1.3%, deionized water add to 100%, mix and make 20% second worm nitrile Rynaxypyr suspending agent.
Example 12 35% second worm nitrile Rynaxypyr suspending agents
Second worm nitrile 20%, Rynaxypyr 15%, two (alkyl) naphthalenesulfonate formaldehyde condensation compound 7%, wetting and penetrating agent F 6%, silicone compound 0.2%, sodium phosphate trimer 1.5%, glycerine 1.2%, deionized water add to 100%, mix and make 35% second worm nitrile Rynaxypyr suspending agent.
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.First pass through Toxicity Determination, co-toxicity coefficient (CTC) after clear and definite two kinds of medicaments are composite by a certain percentage, CTC < 80 is antagonism, 80≤CTC≤120 are summation action, CTC > 120 is synergistic effect, on this basis, then carry out field trial.
Test method: respectively the mother liquor of the each mixed agent of second worm nitrile effective active composition B is diluted to five series concentration when test, is placed in respectively beaker for subsequent use.Adopt and first soak the method that connects worm after leaf, after the blade of the same size that does not contact any medicament is soaked to 5s in the liquid configuring, take out, naturally dry, put into insect box, then connect for examination 3 instar larvaes, under 25 ℃ of conditions, raise, every processing repeats for 3 times, every to repeat examination borer population used be 20, establishes blank simultaneously, checks dead borer population in 72h, calculate lethality and corrected mortality, try to achieve virulence regression equation and calculate LC
50value.If contrast lethality is greater than 10%, be considered as invalid test.Computing formula is as follows:
Insect corrected mortality is converted into probit value (y), and concentration for the treatment of (μ g/ml) converts logarithm value (x) to, draws virulence regression equation with method of least squares, and calculates thus the value of every kind of medicament.Calculate co-toxicity coefficient CTC according to the abundant equation of Sun Yun.Computing formula following (take second worm nitrile as standard medicament, its toxicity index is 100):
TI × the P of theoretical toxicity index (TTI)=second worm nitrile of M
second worm nitriletI × P of+effective active composition B
effective active composition B
In formula: the mixture that M is different proportionings
P
effective active composition Bfor effective active composition B shared ratio in composition
P
second worm nitrilefor second worm nitrile shared ratio in composition
A is selected from second worm nitrile;
B is selected from following any one insecticide: the one in fipronil bisamide, Rynaxypyr.
Application Example two:
For trying insect: Laphygma exigua Hubner.
Test medicine provides by Shanxi Thompson Biological Technology Co., Ltd..
Experimental scheme: effective lethal concentration scope of determining second worm nitrile, the former medicine of fipronil bisamide and the two different proportioning mixture through preliminary experiment.
Toxicity test result one
The toxicity test of table 1 second worm nitrile proportionings different from fipronil bisamide to Laphygma exigua Hubner
As shown in Table 1, the proportioning of the composite control Laphygma exigua Hubner of second worm nitrile and fipronil bisamide was at 40: 1 to 1: 40 o'clock, co-toxicity coefficient is all greater than 120, illustrate that both all show synergistic effect at mixture in 40: 1 to 1: 40 scopes, especially in the time that second worm nitrile and fipronil bisamide obtain proportioning at 5: 1 to 1: 5, synergistic effect is more obviously outstanding, wherein co-toxicity coefficient maximum in the time that second worm nitrile and fipronil bisamide weight ratio are 1: 1, and synergistic effect is the most obvious.
Application Example three:
For trying insect: rice hoppers.
Test medicine provides by Shanxi Thompson Biological Technology Co., Ltd..
Experimental scheme: effective lethal concentration scope of determining second worm nitrile, the former medicine of Rynaxypyr and the two different proportioning mixture through preliminary experiment.
Toxicity test result two
The toxicity test of table 2 second worm nitrile proportionings different from Rynaxypyr to rice hoppers
As shown in Table 2, the composite proportioning of preventing and treating rice hoppers of second worm nitrile and Rynaxypyr was at 40: 1 to 1: 40 o'clock, co-toxicity coefficient is all greater than 120, illustrate that both all show synergistic effect at mixture in 40: 1 to 1: 40 scopes, especially in the time that second worm nitrile and Rynaxypyr obtain proportioning at 5: 1 to 1: 5, synergistic effect is more obviously outstanding, wherein co-toxicity coefficient maximum in the time that second worm nitrile and Rynaxypyr weight ratio are 1: 1, and synergistic effect is the most obvious.Application Example tetrem worm nitrile and fipronil bisamide and the composite control Laphygma exigua Hubner test of pesticide effectiveness thereof
This experimental establishment is in Bozhou City Mengcheng County, Anhui Province, test medicine is researched and developed, is provided by Shanxi Thompson Biological Technology Co., Ltd., contrast medicament 10% second worm nitrile suspending agent (commercial), 20% fipronil bisamide water dispersible granules (commercial).
Investigation Laphygma exigua Hubner insect pest index before medicine, in their early stage dispenser, investigates insect pest indexes and calculates preventive effect for after dispenser 24 hours, 72 hours.Experimental result is as follows:
Table 3 second worm nitrile, fipronil bisamide and the composite control Laphygma exigua Hubner test of pesticide effectiveness thereof
As can be seen from Table 3, after second worm nitrile and fipronil bisamide are composite, can effectively prevent and treat Laphygma exigua Hubner, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Application Example five second worm nitriles and Rynaxypyr and the composite rice hoppers test of pesticide effectiveness of preventing and treating thereof
This experimental establishment is in Binyang County, Guangxi province Nanning City, test medicine is researched and developed, is provided by Shanxi Thompson Biological Technology Co., Ltd., contrast medicament 10% second worm nitrile suspending agent (commercial), 200 grams per liter Rynaxypyr suspending agents (commercial).
Investigation rice hoppers insect pest index before medicine, in their early stage dispenser, investigates insect pest indexes and calculates preventive effect for after dispenser 24 hours, 72 hours.Experimental result is as follows:
Table 4 second worm nitrile, Rynaxypyr and the composite rice hoppers test of pesticide effectiveness of preventing and treating thereof
As can be seen from Table 4, after second worm nitrile and Rynaxypyr are composite, can effectively prevent and treat rice hoppers, control efficiency is all better than the preventive effect of single dose.In test scope of medication, target crop is had no adverse effects.
Claims (5)
1. contain a Pesticidal combination for second worm nitrile, comprise effective active component, auxiliary agent, it is characterized in that: active components A, B percentage by weight are 1 ~ 40% ︰ 1 ~ 40%, and described active components A is selected from second worm nitrile, and active component B is selected from Rynaxypyr.
2. a kind of Pesticidal combination that contains second worm nitrile according to claim 1, is characterized in that: the percentage by weight of A, two kinds of active components of B is 1 ~ 30% ︰ 1 ~ 30%.
3. the Pesticidal combination that contains second worm nitrile according to claim 2, is characterized in that: the percentage by weight of second worm nitrile and Rynaxypyr is 5 ~ 20% ︰ 5 ~ 20%.
4. the Pesticidal combination that contains second worm nitrile according to claim 1, is characterized in that: composition is made wetting powder, water dispersible granules, suspending agent.
5. the ethiprole insecticidal composition that contains according to claim 1 is for preventing and treating the purposes of the various pests on Cereal, vegetables, ornamental plants, fruit tree.
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| CN103503903A (en) * | 2012-06-15 | 2014-01-15 | 陕西汤普森生物科技有限公司 | High-efficiency insecticidal composition containing dicyclanil |
| KR20150144778A (en) * | 2013-04-19 | 2015-12-28 | 바이엘 크롭사이언스 악티엔게젤샤프트 | Insecticidal synergistic combinations of phthaldiamide derivatives and fipronil or ethiprole |
| CN104115845B (en) * | 2013-04-24 | 2017-11-21 | 陕西美邦农药有限公司 | A kind of high-efficient pesticide composition containing fluorobenzene insect amide |
| CN105557697A (en) * | 2014-10-15 | 2016-05-11 | 陕西美邦农药有限公司 | Efficient pesticide composition containing N-(2-tert-butylamineformoxyl-4-chloro-6-methylphenyl)-1-(3-chloropyridine-2-pyridinyl)-3-fluoro-methoxy-1H-pyrazole-5-carboxamide |
| CN106804597A (en) * | 2015-11-27 | 2017-06-09 | 陕西韦尔奇作物保护有限公司 | A kind of Pesticidal combination of the nitrile of worm containing acetyl and fipronil bisamide |
| CN105454243A (en) * | 2015-12-16 | 2016-04-06 | 济南昊泽环保科技有限公司 | Insecticidal combination containing o-phenylenediamine insecticide and ethiprole |
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