CN108114117A - A kind of Chinese medicine composition for clearing up the stagnant sharp water dissipate-swelling that helps digestion of stomachization and preparation method thereof - Google Patents
A kind of Chinese medicine composition for clearing up the stagnant sharp water dissipate-swelling that helps digestion of stomachization and preparation method thereof Download PDFInfo
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- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses a kind of Chinese medicine compositions for clearing up the stagnant sharp water dissipate-swelling that helps digestion of stomachization and preparation method thereof, belong to modern Chinese traditional medicine field.A kind of Chinese medicine composition for clearing up the stagnant sharp water dissipate-swelling that helps digestion of stomachization, active ingredient are prepared from the following raw materials in parts by weight：200 parts of rheum officinale, 25 parts of fructus gleditsiae, 100 parts of betel nut, 200 parts of kaladana, 100 parts of excrementum pteropi, 100 parts of rhizoma cyperi.It is characteristic of the invention that：The present invention has obtained the preparation method of active ingredient that is reasonable, stablizing according to the physicochemical property of each flavour of a drug ingredient and the result of study of pharmacological action.Using technical solution of the present invention, the drug quality prepared is stably and controllable, curative effect is with existing market sale dosage form compared to significantly improving, the reduction of patient's taking dose.With significant economic and social benefit.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof for clearing up the stagnant sharp water dissipate-swelling that helps digestion of stomachization, in belonging to
Medicine modernizes field.
Background technology
Dyspepsia is also known as stagnant.It is close with western medicine indigestion.This disease can all occur throughout the year, summer and autumn, summer-heat and damp
It is easy to tired and holds back temper, incidence is higher.Each age group of children can all fall ill, but common with infant.Often in flu, diarrhea, infantile malnutrition due to digestive disturbances or intestinalparasites
Merge in card and occur.Weakness of the spleen and the stomach, the infant of inadequate natural endowment and artificial feeding easily falls ill repeatedly.A small number of infant dyspepsia days
Long, delay is lost and is controlled, and spleen and stomach function is badly damaged, and causes infant nutrition and dysplasia, and body is increasingly thin thin, It can be transformed into malnutrition, so the predecessors have the saying that "accumulation is the mother of malnutrition, and no accumulation is not a malnutrition." 《General Treatise on the Cause and Symptoms of Diseases miscellaneous child diseases duke or princess under an emperor》Recorded " place
Food does not disappear times ", " the full time of wound ".
The prescription and preparation method of Binlang Sixiao piece be：Rheum officinale 200g, fructus gleditsiae 25g, betel nut 100g, kaladana 200g, five spirits
Fat 100g, rhizoma cyperi 100g.More than Six-element, rheum officinale, fructus gleditsiae are respectively crushed into fine powder, sieve for subsequent use；Betel nut give as one thinks fit it is broken after use
Water impregnates, added water to cook after being impregnated with together with immersion liquid it is secondary, for the first time 3 it is small when, second 2 it is small when, collecting decoction, filtration, filtrate
It is condensed into cream；Kaladana is according to the percolation (annex page 17) under liquid extract and extract item, for the first time with ethanol as solvent, the
Secondary 60% ethanol as solvent carries out diacolation；Excrementum pteropi, 60% ethanol as solvent of rhizoma cyperi carry out diacolation；Merge above-mentioned each
Percolate recycles ethyl alcohol, is condensed into cream.Above-mentioned two kinds of condensed creams are merged, add in rheum officinale, fructus gleditsiae fine powder and right amount of auxiliary materials,
Particle is made in mixing, dry, be pressed into 640 to get.
The content of the invention
The invention solves first technical problem be to provide it is a kind of clear up the stagnant sharp water dissipate-swelling that helps digestion of stomachization Chinese medicine
Composition.
The invention solves another technical problem be to provide the preparation method of above-mentioned Chinese medicine composition.
To achieve the above object, the present invention uses following technical scheme；
It is a kind of clear up the stagnant sharp water dissipate-swelling that helps digestion of stomachization Chinese medicine composition, active ingredient by following parts by weight original
Material is made：200 parts of rheum officinale, 25 parts of fructus gleditsiae, 100 parts of betel nut, 200 parts of kaladana, 100 parts of excrementum pteropi, 100 parts of rhizoma cyperi.
The active ingredient is prepared using following methods：
1st, each raw material is weighed by raw material proportioning；Rheum officinale, fructus gleditsiae are respectively crushed into fine powder, sieve for subsequent use；Betel nut is given as one thinks fit broken
Be soaked in water after broken, added water to cook after being impregnated with together with immersion liquid it is secondary, for the first time 3 it is small when, second 2 it is small when, collecting decoction, filter
It crosses, filtrate is condensed into cream；Kaladana is made according to the percolation (annex page 17) under liquid extract and extract item with ethyl alcohol for the first time
Solvent for the second time with 60% ethanol as solvent, carries out diacolation；Excrementum pteropi, 60% ethanol as solvent of rhizoma cyperi carry out diacolation；It closes
And above-mentioned each percolate, ethyl alcohol is recycled, is condensed into cream.Above-mentioned two kinds of condensed creams are merged, add in rheum officinale, fructus gleditsiae fine powder and auxiliary
Material is appropriate, and particle is made in mixing, dry, obtains dried object A.
2nd, each raw material is weighed by raw material proportioning；Rheum officinale, fructus gleditsiae are respectively crushed into fine powder, sieve for subsequent use；Betel nut is given as one thinks fit broken
Impregnated after broken with the water of 8 times of amounts, added water to cook after being impregnated with together with immersion liquid it is secondary, for the first time 3 it is small when, second 2 it is small when, merge pan-fried
Liquid, filtration, filtrate are condensed into cream；Kaladana is according to the percolation (annex page 17) under liquid extract and extract item, for the first time with 6
The ethanol as solvent of amount again, second of 60% ethanol as solvent with 6 times of amounts carry out diacolation；Excrementum pteropi, rhizoma cyperi are measured with 6 times
60% ethanol as solvent carries out diacolation；Merge above-mentioned each percolate, recycle ethyl alcohol, be condensed into cream.Above-mentioned two kinds of condensed creams are closed
And rheum officinale, fructus gleditsiae fine powder and right amount of auxiliary materials, mixing are added in, and particle is made, it is dry, obtain dried object A.
Described pharmaceutical composition also contains pharmaceutically acceptable auxiliary material.
The pharmaceutically acceptable auxiliary material is selected from starch, microcrystalline cellulose, sucrose, Aspartame, dextrin, lactose, sugar
Powder, glucose, sodium chloride, sodium cellulose glycolate, crosslinked polyvinylpyrrolidone, magnesium stearate, superfine silica gel powder, vitamin C,
Any one or a few in cysteine, citric acid and sodium sulfite.
The dosage form of the Chinese medicine composition is peroral dosage form, includes but not limited to pill, tablet, capsule or oral liquid.Agent
The selection of type and the dosage of auxiliary material belong to the prior art.
A kind of preparation method for the Chinese medicine composition for clearing up the stagnant sharp water dissipate-swelling that helps digestion of stomachization：
Weigh 200 parts of rheum officinale, 25 parts of fructus gleditsiae, 100 parts of betel nut, 200 parts of kaladana, 100 parts of excrementum pteropi, 100 parts of rhizoma cyperi.
Rheum officinale, fructus gleditsiae are respectively crushed into fine powder, sieve for subsequent use；Betel nut give as one thinks fit it is broken after be soaked in water, add water together with immersion liquid after being impregnated with
Decoct it is secondary, for the first time 3 it is small when, second 2 it is small when, collecting decoction, filtration, filtrate is condensed into cream；Kaladana shines liquid extract
With the percolation (annex page 17) under extract item, for the first time with ethanol as solvent, for the second time with 60% ethanol as solvent, carry out
Diacolation；Excrementum pteropi, 60% ethanol as solvent of rhizoma cyperi carry out diacolation；Merge above-mentioned each percolate, recycle ethyl alcohol, be condensed into cream.
Above-mentioned two kinds of condensed creams are merged, rheum officinale, fructus gleditsiae fine powder and right amount of auxiliary materials, mixing is added in, particle is made, it is dry, it is done
Dry object A.
Preferably preparation method is：Rheum officinale, fructus gleditsiae are respectively crushed into fine powder, sieve for subsequent use；Betel nut give as one thinks fit it is broken after use
The water of 8 times of amounts impregnate, added water to cook after being impregnated with together with immersion liquid it is secondary, for the first time 3 it is small when, second 2 it is small when, collecting decoction, filter
It crosses, filtrate is condensed into cream；Kaladana is according to the percolation (annex page 17) under liquid extract and extract item, for the first time with 6 times of amounts
Ethanol as solvent, second with 60% ethanol as solvent of 6 times of amounts, progress diacolation；Excrementum pteropi, rhizoma cyperi with 6 times amount 60%
Ethanol as solvent carries out diacolation；Merge above-mentioned each percolate, recycle ethyl alcohol, be condensed into cream.Above-mentioned two kinds of condensed creams are merged,
Rheum officinale, fructus gleditsiae fine powder and right amount of auxiliary materials, mixing are added in, particle is made, it is dry, obtain dried object A.
It is a kind of clear up the stagnant sharp water dissipate-swelling that helps digestion of stomachization Chinese medicine composition preparation, said preparation with above-mentioned pharmaceutical activity into
Divide and add in pharmaceutically acceptable auxiliary material, pharmaceutically acceptable dosage form is made.Utilize obtained Chinese medicine composition of the invention
Needed for active ingredient preparation during the various dosage forms of drug, it can be prepared according to the conventional production process of art of pharmacy.Such as should
Active ingredient is mixed with one or more carriers, and corresponding dosage form is then made.
It is an advantage of the invention that：The present invention analyzes composition with theory of traditional Chinese medical science, according to the reason of each flavour of a drug ingredient
Change property and pharmacological action, study and obtained the preparation method of active ingredient that is reasonable, stablizing.Technical side using the present invention
Case, it is on duty go out stable and controllable for quality, curative effect significantly improved compared with existing commercial dosage forms, the drug of patient's taking dose reduction
Preparation has significant economic and social benefit.
Technical solution that the present invention will be described in detail by the following examples does not limit the practical range of the present invention with this.
Specific embodiment
Embodiment 1：Prepare Chinese medical extract
First, prescription：Rheum officinale 200g, fructus gleditsiae 25g, betel nut 100g, kaladana 200g, excrementum pteropi 100g, rhizoma cyperi 100g
2nd, preparation method：
Rheum officinale, fructus gleditsiae are respectively crushed into fine powder, sieve for subsequent use；Betel nut give as one thinks fit it is broken after impregnated with the water of 8 times of amounts, soak
Added water to cook after thoroughly together with immersion liquid it is secondary, for the first time 3 it is small when, second 2 it is small when, collecting decoction, filtration, filtrate is condensed into cream；
Kaladana is according to the percolation (annex page 17) under liquid extract and extract item, the ethanol as solvent measured for the first time with 6 times, and second
Secondary 60% ethanol as solvent with 6 times of amounts carries out diacolation；Excrementum pteropi, rhizoma cyperi 60% ethanol as solvent of 6 times of amounts, are oozed
It filters；Merge above-mentioned each percolate, recycle ethyl alcohol, be condensed into cream.Above-mentioned two kinds of condensed creams are merged, it is thin to add in rheum officinale, fructus gleditsiae
Particle is made in powder and right amount of auxiliary materials, mixing, dry, obtains dried object 400g.
Embodiment 2：Prepare Chinese medical extract
First, prescription：Rheum officinale 200kg, fructus gleditsiae 25kg, betel nut 100kg, kaladana 200kg, excrementum pteropi 100kg, rhizoma cyperi
100kg。
2nd, preparation method：
Rheum officinale, fructus gleditsiae are respectively crushed into fine powder, sieve for subsequent use；Betel nut give as one thinks fit it is broken after impregnated with the water of 8 times of amounts, soak
Added water to cook after thoroughly together with immersion liquid it is secondary, for the first time 3 it is small when, second 2 it is small when, collecting decoction, filtration, filtrate is condensed into cream；
Kaladana is according to the percolation (annex page 17) under liquid extract and extract item, the ethanol as solvent measured for the first time with 6 times, and second
Secondary 60% ethanol as solvent with 6 times of amounts carries out diacolation；Excrementum pteropi, rhizoma cyperi 60% ethanol as solvent of 6 times of amounts, are oozed
It filters；Merge above-mentioned each percolate, recycle ethyl alcohol, be condensed into cream.Above-mentioned two kinds of condensed creams are merged, it is thin to add in rheum officinale, fructus gleditsiae
Particle is made in powder and right amount of auxiliary materials, mixing, dry, obtains dried object 400kg.
Embodiment 3：Prepare tablet
The active ingredient 100g that embodiment 1 obtains, adds microcrystalline cellulose 40g, cross-linked pvp 7g, tabletting, obtains tablet, every
Weight 0.6g.
Embodiment 4：Prepare capsule
The active ingredient 1000g that embodiment 2 obtains, adds starch 250g, and encapsulating capsule obtains capsule, every weight 0.50g.
Claims (8)
1. it is a kind of clear up the stagnant sharp water dissipate-swelling that helps digestion of stomachization Chinese medicine composition, active ingredient by following parts by weight raw material
It is made：200 parts of rheum officinale, 25 parts of fructus gleditsiae, 100 parts of betel nut, 200 parts of kaladana, 100 parts of excrementum pteropi, 100 parts of rhizoma cyperi.
2. a kind of Chinese medicine composition for clearing up the stagnant sharp water dissipate-swelling that helps digestion of stomachization according to claim 1, it is characterised in that
The active ingredient is prepared using following methods：Rheum officinale, fructus gleditsiae are respectively crushed into fine powder, sieve for subsequent use；Betel nut is given as one thinks fit
Be soaked in water after broken, added water to cook after being impregnated with together with immersion liquid it is secondary, for the first time 3 it is small when, second 2 it is small when, collecting decoction, filter
It crosses, filtrate is condensed into cream；Kaladana is made according to the percolation (annex page 17) under liquid extract and extract item with ethyl alcohol for the first time
Solvent for the second time with 60% ethanol as solvent, carries out diacolation；Excrementum pteropi, 60% ethanol as solvent of rhizoma cyperi carry out diacolation；It closes
And above-mentioned each percolate, ethyl alcohol is recycled, is condensed into cream.Above-mentioned two kinds of condensed creams are merged, add in rheum officinale, fructus gleditsiae fine powder and auxiliary
Material is appropriate, and particle is made in mixing, dry, obtains dried object A.
3. a kind of Chinese medicine composition for clearing up the stagnant sharp water dissipate-swelling that helps digestion of stomachization according to claim 2, it is characterised in that：
Rheum officinale, fructus gleditsiae are respectively crushed into fine powder, sieve for subsequent use；Betel nut give as one thinks fit it is broken after with the water immersions of 8 times of amounts, after being impregnated with together with
Immersion liquid add water to cook it is secondary, for the first time 3 it is small when, second 2 it is small when, collecting decoction, filtration, filtrate is condensed into cream；Kaladana is shone
Liquid extract and the percolation (annex page 17) under extract item, for the first time with the ethanol as solvent of 6 times of amounts, second with 6 times
60% ethanol as solvent of amount carries out diacolation；Excrementum pteropi, rhizoma cyperi 60% ethanol as solvent of 6 times of amounts, carry out diacolation；Merge
Above-mentioned each percolate recycles ethyl alcohol, is condensed into cream.Above-mentioned two kinds of condensed creams are merged, add in rheum officinale, fructus gleditsiae fine powder and auxiliary material
In right amount, particle is made in mixing, dry, obtains dried object A.
4. a kind of Chinese traditional medicine composition of the stagnant sharp water dissipate-swelling that helps digestion of cleaning stomachization according to any one of claims 1 to 3
Object, it is characterised in that：Affiliated drug also contains pharmaceutically acceptable auxiliary material.
5. a kind of Chinese medicine composition for clearing up the stagnant sharp water dissipate-swelling that helps digestion of stomachization according to claim 4, it is characterised in that：
The pharmaceutically acceptable auxiliary material is selected from starch, microcrystalline cellulose, sucrose, Aspartame, dextrin, lactose, Icing Sugar, grape
Sugar, sodium chloride, sodium cellulose glycolate, crosslinked polyvinylpyrrolidone, magnesium stearate, superfine silica gel powder, vitamin C, half Guang ammonia
Any one or a few in acid, citric acid and sodium sulfite.
6. a kind of Chinese medicine composition for clearing up the stagnant sharp water dissipate-swelling that helps digestion of stomachization according to claim 4, it is characterised in that：
The dosage form of the Chinese medicine composition is peroral dosage form, including pill, tablet, capsule or oral liquid.
7. a kind of preparation method for the Chinese medicine composition for clearing up the stagnant sharp water dissipate-swelling that helps digestion of stomachization, it is characterised in that：Rheum officinale 200
Part, 25 parts of fructus gleditsiae, 100 parts of betel nut, 200 parts of kaladana, 100 parts of excrementum pteropi, 100 parts of rhizoma cyperi.Rheum officinale, fructus gleditsiae crush respectively
Into fine powder, sieve for subsequent use；Betel nut give as one thinks fit it is broken after be soaked in water, add water to cook together with immersion liquid secondary after being impregnated with, 3 is small for the first time
When, second 2 it is small when, collecting decoction, filtration, filtrate is condensed into cream；Kaladana is according to the diacolation under liquid extract and extract item
Method (annex page 17) for the first time with ethanol as solvent, for the second time with 60% ethanol as solvent, carries out diacolation；Excrementum pteropi, rhizoma cyperi are used
60% ethanol as solvent carries out diacolation；Merge above-mentioned each percolate, recycle ethyl alcohol, be condensed into cream.Above-mentioned two kinds of condensed creams are closed
And rheum officinale, fructus gleditsiae fine powder and right amount of auxiliary materials, mixing are added in, and particle is made, it is dry, obtain dried object A.
8. in a kind of cleaning stagnant sharp water dissipate-swelling that helps digestion of stomachization according to claim 1 according to claim 7
Drug composition, it is characterised in that：200 parts of rheum officinale, 25 parts of fructus gleditsiae, 100 parts of betel nut, 200 parts of kaladana, 100 parts of excrementum pteropi, perfume
Attached 100 parts.Rheum officinale, fructus gleditsiae are respectively crushed into fine powder, sieve for subsequent use；Betel nut give as one thinks fit it is broken after impregnated with the water of 8 times of amounts, soak
Added water to cook after thoroughly together with immersion liquid it is secondary, for the first time 3 it is small when, second 2 it is small when, collecting decoction, filtration, filtrate is condensed into cream；
Kaladana is according to the percolation (annex page 17) under liquid extract and extract item, the ethanol as solvent measured for the first time with 6 times, and second
Secondary 60% ethanol as solvent with 6 times of amounts carries out diacolation；Excrementum pteropi, rhizoma cyperi 60% ethanol as solvent of 6 times of amounts, are oozed
It filters；Merge above-mentioned each percolate, recycle ethyl alcohol, be condensed into cream.Above-mentioned two kinds of condensed creams are merged, it is thin to add in rheum officinale, fructus gleditsiae
Particle is made in powder and right amount of auxiliary materials, mixing, dry, obtains dried object A.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110507743A (en) * | 2019-09-06 | 2019-11-29 | 山西正元盛邦制药有限公司 | One kind helps digestion stagnant gas ball preparation process |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110507743A (en) * | 2019-09-06 | 2019-11-29 | 山西正元盛邦制药有限公司 | One kind helps digestion stagnant gas ball preparation process |
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Addressee: Longshunrong Pharmaceutical Factory, Tianjin, Zhongxin, Pharmaceutical Group Co. Document name: Notification of before Expiration of Request of Examination as to Substance |
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