CN108079246A - A kind of medium-height grass medicinal gel and preparation method thereof - Google Patents
A kind of medium-height grass medicinal gel and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/902—Sparganiaceae (Bur-reed family)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0041—Mammary glands, e.g. breasts, udder; Intramammary administration
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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Abstract
The invention discloses a kind of medium-height grass medicinal gel, including following component based on parts by weight of raw materials：10~15 parts of Chinese herbal medicine extract, 60~85 parts of Macromolecule gel matrix, 20~45 parts of triethanolamine, 0.02~0.06 part of Phenoxyethanol, 0.1~0.5 part of Laurocapram, 1~3 part of borneol.The present invention by adjusting medium-height grass medicinal gel raw material components and proportioning, Chinese herbal medicine extract is mixed with Macromolecule gel matrix, and using triethanolamine, Phenoxyethanol, Laurocapram and borneol as auxiliary material, i.e. by way of gel cold compress physical therapy, make vessel retraction, anti-inflammatory analgetic, breast microcirculation can be effectively improved, while substantially increases the epidermal absorption ability of Chinese herbal medicine extract.
Description
Technical field
The present invention relates to tcm field, more particularly to a kind of medium-height grass medicinal gel.
Background technology
Proliferation of mammary gland patient is the people at highest risk of breast cancer, and the incidence of China's female mammary gland proliferation becomes in rising year by year
Gesture, with society and nature's environmental change, the composite factors such as dietary structure changes, and fertility is reduced, and stress is big are related.The proliferation of mammary gland
It is women of child-bearing age's common disease and frequently-occurring disease, accounts for the 75% of whole mastosises, wherein canceration occurs for the patient there are about 2~5%, it must
It must draw attention.However, at present for this kind of mammary gland disease of the proliferation of mammary gland common treatment means only there are two types of, one kind is to swash
Based on extract for treating, such as methyl testosterone, medroxyproges-terone acetate, tamoxifen, cause with certain curative effect but easily menstruation
Disorder, secondary characteristic change etc., another kind are surgically removal of lesions, but lose painful, the high expense of breast
And high recurrence rate makes numerous women deep bitter by it.
The etiology and pathogenesis of mammary gland disease is mainly stagnation of liver qi, loses and is rushed down in thin, newborn network retardance, caused by hematogenous blockage, the rules for the treatment of
With dispersing stagnated hepatoqi, based on promoting blood circulationization addiction, gas along blood and, caking is from disappearing.At present, though the drug for treating mammary gland disease on the market is more,
But for various reasons, using effect and curative effect are irregular, unsatisfactory, therefore explore safer and more effective medicine
Just seem extremely urgent.
The content of the invention
It is an object of the invention in view of the above shortcomings of the prior art, provide a kind of medium-height grass medicinal gel, to mammary gland disease
Disease has the effect of efficient, and can effectively prevent mammary gland disease.Present invention simultaneously provides the preparation methods of the medium-height grass medicinal gel.
The technical solution used in the present invention is：A kind of medium-height grass medicinal gel, including following component based on parts by weight of raw materials：
As being further improved for said program, the Chinese herbal medicine extract includes by weight：2~4 parts of frankincense, three
2~4 parts of rib, 2~4 parts of zedoary, 4~6 parts of glutinous rehmannia, 4~6 parts of Radix Aucklandiae, 4~6 parts of the seed of cowherb, 5~8 parts of safflower, dandelion 5
~8 parts, 5~8 parts of Fructus Liquidambaris, 2~3 parts of Chinese prickly ash, 2~3 parts of akebi.Specifically, raw material medicinal ingredient is described below：
Frankincense：For the resin that olive subject plant Boswellia carterii and congener bark ooze out, there is blood-activating and qi-promoting analgesic, detumescence
The effect of myogenic.
Trigone：For Sparganiaceae plant rhizoma scirpi or small rhizoma scirpi, the stem tuber of spire rhizoma scirpi, there is blood-breaking, disappear
Product analgesic the effect of, cure mainly the stagnant Amenorrhea of abdominal mass lump in the abdomen, the stasis of blood, dysmenorrhoea, dyspepsia distending pain, fall year the pain of injury.
Zedoary：For the dry rhizome of Zingiber herbaceos perennial curcuma zedoary, RADIX CURCUMAE or Guangxi zedoary, dispel with blood-breaking
The effect of stasis of blood, promoting qi circulation and relieving pain, cures mainly Amenorrhea abdominal pain, lump in the abdomen accumulation, abdominal fullness and distention pain.
Glutinous rehmannia：For the fresh or dried root of scrophulariaceae rehmannia glutinosa plant, there is clearing heat and cooling blood, yin-nourishing, the effect of promoting the production of body fluid.
Radix Aucklandiae：For the root of feverfew Radix Aucklandiae, there is promoting qi circulation and relieving pain, reinforcing spleen to promote digestion.
The seed of cowherb：For the dry mature seed of pinkwort cow-fat, there is invigorate blood circulation, lower breast detumescence, diuresis
The effect for the treatment of stranguria.
Safflower：For the tubular corolla of feverfew safflower, there is blood promoting menstruation, removing blood stasis and analgesics, be usually used in Amenorrhea, pain
Through, lochia, abdominal mass lump in the abdomen, traumatic injury.
Dandelion：For herbaceos perennial, have clearing heat and detoxicating；, there is acute mastitis in the effect of carbuncle that disappears dissipating bind good effect, energy
Detoxicating and resolving a mass promoting lactation.
Fructus Liquidambaris：For the drying and ripening infructescence of Hamamelidaceae Plants Chinese sweet gum, there is the effect of dispelling, collateral-activating, sharp water.
Chinese prickly ash：For the pericarp of rutaceae Chinese prickly ash, there is warming spleen and stomach for dispelling cold, expelling parasite, antipruritic.
Akebi：For dicotyledon medicine plants of Lardizabalaceae akebia trifoliata varaustralis or threeleaf akebia, the woody stems of akebi, there is heat-clearing profit
Urine；The effect of blood circulation and channel invigorating, controls hot urination, and stranguria with turbid discharge, oedema is irritable feverish sensation in chest, larynx numbness pharyngalgia, inflexible pain all over, women's Amenorrhea, breast
Juice is obstructed.
A kind of preparation method of medium-height grass medicinal gel as described above is through extracting to obtain Chinese herbal medicine extraction after Chinese herbal medicine is milled
Object, then by Chinese herbal medicine extract and Macromolecule gel matrix, triethanolamine, Phenoxyethanol, Laurocapram and borneol in room temperature
Lower be uniformly mixed forms gel.
The beneficial effects of the invention are as follows：
The present invention by adjusting medium-height grass medicinal gel raw material components and proportioning, by Chinese herbal medicine extract and Macromolecule matrix
Matter mixes, and using triethanolamine, Phenoxyethanol, Laurocapram and borneol as auxiliary material, that is, passes through the side of gel cold compress physical therapy
Formula makes vessel retraction, anti-inflammatory analgetic, can be effectively improved breast microcirculation, while substantially increases the epidermis of Chinese herbal medicine extract
Absorbability.
The present invention is by adjusting the medicinal ingredient and proportioning in Chinese herbal medicine extract, to breasts such as Breast Nodules, the proliferations of mammary gland
Gland disease has significant curative effect.Clinical effectiveness shows that patient smears the once gel daily, and 7 days as a course for the treatment of, a course for the treatment of
After can effectively alleviate swollen breasts, newborn slag can be discharged after two courses for the treatment of, breast can obtain simultaneously for mammary gland disease rehabilitation after three courses for the treatment of
It is nourished to effective.
Specific embodiment
The present invention is specifically described with reference to embodiment, in order to technical field personnel to the present invention
Understand.It is necessary to it is emphasized that embodiment is only intended to, the present invention will be further described herein, it is impossible to be interpreted as to this
The limitation of invention protection domain, fields person skilled in the art, the non-intrinsically safe made according to foregoing invention content to the present invention
The modifications and adaptations of property, should still fall within protection scope of the present invention.Mentioned raw materials following simultaneously are unspecified, are
Commercial product；The processing step or preparation method not referred in detail be processing step known to a person skilled in the art or
Preparation method.
Embodiment 1
A kind of medium-height grass medicinal gel, including following component based on parts by weight of raw materials：
Wherein, the Chinese herbal medicine extract includes by weight：2 parts of frankincense, 2 parts of trigone, 2 parts of zedoary, glutinous rehmannia 6
Part, 6 parts of Radix Aucklandiae, 6 parts of the seed of cowherb, 5 parts of safflower, 5 parts of dandelion, 5 parts of Fructus Liquidambaris, 3 parts of Chinese prickly ash, 3 parts of akebi.Preparation method：
Based on parts by weight of raw materials by after above-mentioned each herbal component milling through extracting to obtain Chinese herbal medicine extract, then by raw material weight
Part meter is measured by Chinese herbal medicine extract and Macromolecule gel matrix, triethanolamine, Phenoxyethanol, Laurocapram and borneol in room temperature
It is lower to be uniformly mixed, obtain 1 finished gel of embodiment.
Embodiment 2
A kind of medium-height grass medicinal gel, including following component based on parts by weight of raw materials：
Wherein, the Chinese herbal medicine extract includes by weight：4 parts of frankincense, 4 parts of trigone, 4 parts of zedoary, glutinous rehmannia 4
Part, 4 parts of Radix Aucklandiae, 4 parts of the seed of cowherb, 8 parts of safflower, 8 parts of dandelion, 8 parts of Fructus Liquidambaris, 2 parts of Chinese prickly ash, 2 parts of akebi.Preparation method：
Based on parts by weight of raw materials by after above-mentioned each herbal component milling through extracting to obtain Chinese herbal medicine extract, then by raw material weight
Part meter is measured by Chinese herbal medicine extract and Macromolecule gel matrix, triethanolamine, Phenoxyethanol, Laurocapram and borneol in room temperature
It is lower to be uniformly mixed, obtain 2 finished gel of embodiment.
Embodiment 3
A kind of medium-height grass medicinal gel, including following component based on parts by weight of raw materials：
Wherein, the Chinese herbal medicine extract includes by weight：3 parts of frankincense, 3 parts of trigone, 3 parts of zedoary, glutinous rehmannia 5
Part, 5 parts of Radix Aucklandiae, 5 parts of the seed of cowherb, 6 parts of safflower, 6 parts of dandelion, 6 parts of Fructus Liquidambaris, 2.5 parts of Chinese prickly ash, 2.5 parts of akebi.
Preparation method：
Based on parts by weight of raw materials by after above-mentioned each herbal component milling through extracting to obtain Chinese herbal medicine extract, then by raw material weight
Part meter is measured by Chinese herbal medicine extract and Macromolecule gel matrix, triethanolamine, Phenoxyethanol, Laurocapram and borneol in room temperature
It is lower to be uniformly mixed, obtain 3 finished gel of embodiment.
Embodiment 4
A kind of medium-height grass medicinal gel, including following component based on parts by weight of raw materials：
Wherein, the Chinese herbal medicine extract includes by weight：2.5 parts of frankincense, 4 parts of trigone, 2 parts of zedoary, glutinous rehmannia
4.5 parts, 5.5 parts of Radix Aucklandiae, 4 parts of the seed of cowherb, 6 parts of safflower, 7 parts of dandelion, 7 parts of Fructus Liquidambaris, 2 parts of Chinese prickly ash, 3 parts of akebi.
Preparation method：
Based on parts by weight of raw materials by after above-mentioned each herbal component milling through extracting to obtain Chinese herbal medicine extract, then by raw material weight
Part meter is measured by Chinese herbal medicine extract and Macromolecule gel matrix, triethanolamine, Phenoxyethanol, Laurocapram and borneol in room temperature
It is lower to be uniformly mixed, obtain 4 finished gel of embodiment.
Embodiment 5
A kind of medium-height grass medicinal gel, including following component based on parts by weight of raw materials：
Wherein, the Chinese herbal medicine extract includes by weight：4 parts of frankincense, 4 parts of trigone, 3 parts of zedoary, glutinous rehmannia 4
Part, 4 parts of Radix Aucklandiae, 5 parts of the seed of cowherb, 7 parts of safflower, 7 parts of dandelion, 7 parts of Fructus Liquidambaris, 3 parts of Chinese prickly ash, 3 parts of akebi.Preparation method：
Based on parts by weight of raw materials by after above-mentioned each herbal component milling through extracting to obtain Chinese herbal medicine extract, then by raw material weight
Part meter is measured by Chinese herbal medicine extract and Macromolecule gel matrix, triethanolamine, Phenoxyethanol, Laurocapram and borneol in room temperature
It is lower to be uniformly mixed, obtain 5 finished gel of embodiment.
Embodiment 6：Clinical practice
1st, case standard
1.1 general information
In January, 2017~July successively treats 300 patients of the proliferation of mammary gland with medicine of the present invention, is women, and the age is minimum
Person 18 years old, the maximum 52 years old, average age 36.8 years old；Unmarried 85, married 215；The course of disease most short person two weeks, most elder 8 weeks.
Bilateral breast hyperplasia 193, the unilateral proliferation of mammary gland 107.
1.2 diagnostic criteria
Reference《New Chinese medicine guideline of clinical investigations》、《Surgery of Chinese Medicine》(the 6th edition) formulation.With breast pain,
The clinical manifestation of lump in breast is shown in that gland tissue echo is disorderly in mammary gland or Echoenhance owes equal with reference to mammary gland Colour ultrasound diagnosis
Even, the visible cryptomere expansion of conduit, clinical diagnosis is cyclomastopathy.
1.3 diagnosis indexing standards
Slight hyperplasia：Regular premenstruum (premenstrua) distending pain, voluntarily alleviates after, the slightly plump sense touched, and without apparent tubercle,
For near infrared light image without apparent shade, blood vessel end or tube wall are crude or have small point-like or ghost.
Moderate hyperplasia：Swollen breasts substantially aggravate or without conscious feeling of pains, but tenderness is apparent, tactile nodosity or plumpness
Sense and obscure boundary Chu lump, near infrared light image, blood vessel traveling naturally, wall it is crude and with ghost or localized vascular
Increase, be also shown sheet, cloud light gray shadow or capsule local transparent shape.
Severe hyperplasia：The same moderate of clinical symptoms, touch within have apparent tubercle, plump, the lump obscure boundary of tenderness, tubercle
Quality is hard, and near infrared light image has diffusivity or the shallow middle ghost of limitation or entire breast in cloud, blood vessel traveling disorder
Increase, is thickening, crude etc..
1.4 inclusion criteria
Inclusion criteria：Meet Diagnosis of Cyclomastopathy standard.Age between 18-50 Sui, women, menstrual cycle and menstrual period
Substantially regular, the menstrual cycle is (28 ± 7) day.Previously there is a periodically premenstrual mastodynia shape, the course of disease is lasting >=and 3 months.1 month
Within do not receive the treatment of cyclomastopathy, steroids preparation person is not used within half a year.Skin of breast is complete, no breakage, nothing
Skin disease.
Exclusion criteria：Merge malignant breast tumor, inflammatory and other endocrine system diseases person.Menstrual cycle or menstrual period are serious
Irregular person.It is associated with the severe primaries such as cardiovascular and cerebrovascular, liver, kidney, hemopoietic system disease or mental patient.Gestation
Phase, nursing period, menopause and preparation pregnant woman.Allergic constitution is known to such drug or constituent allergy sufferers.
Participating in other clinical drug trials person.
2nd, therapeutic scheme
300 patients are equally divided into 5 groups according to the age, every group of patient uses Examples 1 to 5 finished gel conduct respectively
The drug of mammary gland disease is treated, smearing corresponding finished gel daily, simultaneously once, 7 times as a treatment course for massaging breasts, checks within 3rd
1 time, cured person continues 1 course for the treatment of of medication, not more continual cure, most 5 courses for the treatment of of medication.Menstrual period continues medication.It smears
After local skin allergy sufferers can disable 3 days or symptomatic treatment after gel, it is further continued for using.Other treatment medicine is disabled during treatment
Object.
3rd, criterion of therapeutical effect and result
3.1 standard
By State Administration of Traditional Chinese Medicine《Chinese medical disease Standardization of diagnosis and curative effect》And《New Chinese medicine treats cystic hyperplasia of mammary gland
The guideline of clinical investigations of disease》It works out.
It cures：Lump in breast and pain disappear, mammary gland near infrared light transillumination or Color B-Type Ultrasonic inspection prompting breast lesion sign
It disappears, does not recur within 3 months after drug withdrawal；
Effectively：Lump in breast is obviously reduced, pain relief or disappearance, and mammary gland near infrared light transillumination or Color B-Type Ultrasonic inspection carry
Show that breast lesion sign is obviously reduced or improves；
It is invalid：Lump in breast and pain is unchanged or variation is little, mammary gland near infrared light transillumination or Color B-Type Ultrasonic inspection prompting
Breast lesion sign is unchanged.
3.2 treatment results
300 patients are after treatment, wherein disappear after medication in 3 weeks after the newborn slag of discharge with clinical symptoms, Ge Xiangjian
It is normal to test index, follow-up does not recur 286 in March；Clinical symptoms are clearly better, and every test rating is normal or close to normally
10；Clinical symptoms improve, unstable 4 of curative effect.Cure rate is 95.3%, improvement rate 3.3%；Total effective rate is
98.6%.
Above-described embodiment is the preferred embodiment of the present invention, all with similar technique of the invention and the equivalence changes made,
The protection category of the present invention should all be belonged to.
Claims (3)
1. a kind of medium-height grass medicinal gel, which is characterized in that including following component based on parts by weight of raw materials：
2. a kind of medium-height grass medicinal gel according to claim 1, it is characterised in that：The Chinese herbal medicine extract is by weight
Including：2~4 parts of frankincense, 2~4 parts of trigone, 2~4 parts of zedoary, 4~6 parts of glutinous rehmannia, 4~6 parts of Radix Aucklandiae, 4~6 parts of the seed of cowherb,
5~8 parts of safflower, 5~8 parts of dandelion, 5~8 parts of Fructus Liquidambaris, 2~3 parts of Chinese prickly ash, 2~3 parts of akebi.
3. a kind of a kind of preparation method of medium-height grass medicinal gel as claimed in claim 1 or 2, it is characterised in that：Chinese herbal medicine is milled
By Chinese herbal medicine extract is extracted to obtain, by Chinese herbal medicine extract and Macromolecule gel matrix, triethanolamine, Phenoxyethanol, bay
Azone and borneol are uniformly mixed under room temperature, obtain finished gel.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112089813A (en) * | 2020-10-21 | 2020-12-18 | 广州喜妆生物科技有限公司 | Traditional Chinese medicine micromolecule essence emulsion capable of promoting blood circulation to remove blood stasis and removing stasis to dredge |
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| CN103341046A (en) * | 2013-07-29 | 2013-10-09 | 河南中医学院 | Traditional Chinese medicine membrane for treating hyperplasia of mammary glands |
| CN104623562A (en) * | 2015-03-11 | 2015-05-20 | 尹岩伟 | Pharmaceutical composition for treating hyperplasia of mammary glands and breast tumors |
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2017
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1453031A (en) * | 2003-04-25 | 2003-11-05 | 张怡 | Externally-applied medicine composition for treating mastoproliferation and its prepn |
| CN103341046A (en) * | 2013-07-29 | 2013-10-09 | 河南中医学院 | Traditional Chinese medicine membrane for treating hyperplasia of mammary glands |
| CN104623562A (en) * | 2015-03-11 | 2015-05-20 | 尹岩伟 | Pharmaceutical composition for treating hyperplasia of mammary glands and breast tumors |
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| CN112089813A (en) * | 2020-10-21 | 2020-12-18 | 广州喜妆生物科技有限公司 | Traditional Chinese medicine micromolecule essence emulsion capable of promoting blood circulation to remove blood stasis and removing stasis to dredge |
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