CN104623562A - Pharmaceutical composition for treating hyperplasia of mammary glands and breast tumors - Google Patents
Pharmaceutical composition for treating hyperplasia of mammary glands and breast tumors Download PDFInfo
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Abstract
The invention relates to a pharmaceutical composition for treating hyperplasia of mammary glands and breast tumors. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 45 parts of nutgrass galingale rhizome, 45 parts of snakegourd fruit, 40 parts of pangolin scales, 40 parts of eucommia bark, 35 parts of tuckahoe, 35 parts of dahurian angelica root, 35 parts of zedoary rhizome, 30 parts of myrrh, 30 parts of common burreed rhizome, 30 parts of tree peony bark, 25 parts of szechuan lovage rhizome, 25 parts of frankincense, 25 parts of Chinese angelica, 25 parts of heartleaf houttuynia herb, 25 parts of dandelion, 20 parts of inula flower, 20 parts of weeping forsythia capsule, 18 parts of safflower, 18 parts of wrinkled gianthyssop herb, 18 parts of Chinese dodder seed, 15 parts of gamboge, 15 parts of white peony root, 15 parts of the root of red-rooted salvia, 15 parts of root of sinkiang arnebia, 12 parts of cowherb seed, 8 parts of peach kernels, 8 parts of Chinese gall, 5 parts of pseudo-ginseng and 5 parts of liquorice root. The pharmaceutical composition is capable of treating both symptoms and root causes, nontoxic and harmless to a human body, free from side effect, low in cost, and simple and convenient to produce, and has a wide application prospect.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of pharmaceutical composition being used for the treatment of cyclomastopathy and breast tumor.
Background technology
Mastopathy is one of principal disease of harm WomanHealth, and the lighter's cyclomastopathy long pain, severe one even develops into breast tumor, has a strong impact on women's physical and mental health.Cyclomastopathy is also known as mammary dysplasia, fibrocystic disease of breast, it is a kind of disease of comprehensive various clinical disease, comprise mammoplasia's disease (mastalgia), adenosis of breast, cystic cyclomastopathy etc., cyclomastopathy is commonly encountered diseases, the frequently-occurring disease of young women, its sickness rate occupies mastopathy first place, accounts for 60% ~ 70%.Main manifestations is distending pain of the breast and breast caking, and how to change with menstrual cycle or feelings will and to change.Age of onset can be any adult female, wherein 30-40 year occurred frequently, the sickness rate of Women of childbearing age is 40%, accounts for mastotic 2/3, in recent years in obvious ascendant trend.The canceration rate of cyclomastopathy patient is about the 1.5-2 of general population doubly, and wherein atypical hyperplasia is 5 times, and therefore this disease has a strong impact on women's health, and control receives the concern of country, society, academia.
Cyclomastopathy is the disorder of the mammary gland normal configuration that a kind of physiology hypertrophy and subinvolution cause in essence, clinical with lump in breast and mastalgia for principal character, symptom generally normal in premenstruum increase the weight of, pass through after alleviate.This sick sickness rate is in ascendant trend year by year in recent years, and has the tendency that becomes younger.The dangerous compared with normal women that primary disease cancerates increases 2-4 doubly, and clinical symptoms and sign are easily mixed with cyclomastopathy sometimes mutually.During this onste, patient is anxious because of lump in breast pain, and work and life are had a strong impact on, therefore give early treatment to this disease energetically, no matter at disease therapy itself, or in control canceration, all has very important significance.
Modern medicine is still very not clear at present to the etiology and pathogenesis of this disease, and most scholar thinks that this disease and endocrine function are lacked of proper care relevant with Nervous and Mental Factors, and it is this pathogenetic major reason that Progesterone secretion reduces increase relative with estrogen.Drug therapy is based on hormones preparation, although short-term effect is good, can obvious relief of symptoms, but curative effect is unstable, easily recurs after drug withdrawal, prolonged application can disturb the balance between human hormone, cause the side effect such as menoxenia, secondary sex characteristics change, and have the risk increasing canceration, therefore generally as routine administration, only should not consider application when serious symptom.Operative therapy is applicable to the patient that severe hypertrophy has the tendency that cancerates, but easily causes body to damage, and very easily recurs.How undesirable endo-medicine curative effect is also.There is no the specific medicament of this disease for the treatment of at present.
Motherland's medical science thinks that this disease belongs to traditional Chinese medical science “ Ru Repair-in ", " newborn painful abdominal mass ", " nodule in the breast " category; its morbidity is relevant with the many factors such as feelings will, fatigue, diet, body constitution; pathogenesis key is that qi depression to blood stasis, phlegm-damp condense, while with the internal organs such as liver spleen kidney and to rush wantonly two arteries and veins in close relations.The traditional Chinese medical science by dialectical treat treatment primary disease long-standing, the Therapeutic Method of clinical accumulation and more for the treatment of means disappear except sheet, serial Chinese patent medicine such as newborn disease spirit granule, RUKUAIXIAO PIAN etc. Chu Ru Repair-in, also have a large amount of folk prescription, proved recipe, acupuncture, massage, cupping jar, magnetic medicine chest protecting device etc.Facts have proved, tcm therapy Be very effective, few side effects, with Western medicine share also can attenuation synergistic, reduce relapse rate.
Prior art is in the treatment of cyclomastopathy, and Western medicine side effect causes anxiety, and Chinese medicine is comparatively conventional, but can effective lenitive Chinese patent medicine kind few, curative effect is not satisfactory.In view of the market demand of this sick medicine is very large, pole is necessary the Chinese patent medicine preparation developing new determined curative effect, for clinician provides more medication to select.Using Chinese medicine to alleviate mammary gland pain and tuberosity is widely used Therapeutic Method clinically at present, and Chinese medicine directly can be imposed on affected part by external treatment of tcm, and by Transdermal absorption, the efficacy of a drug is gone directly disease institute, thus improves bioavailability.At present, the medicine for the treatment of cyclomastopathy is a lot, but for various reasons, and it uses and curative effect unsatisfactory, therefore explores safer and more effective medicine and just seems very urgent.
Summary of the invention
The technical problem to be solved in the present invention alleviates patient's misery for providing one, more effectively treats cyclomastopathy and breast tumor (benign tumor) medicative pure Chinese medicinal preparation, the present invention combines clinical experience for many years on the basis of traditional medicine, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways collect soothing the liver eliminating stagnation, the natural Chinese medicine of the chest stuffiness relieving of regulating the flow of vital energy, menstruction regulating and pain relieving, adopt modern processing method meticulously develop.The present invention, to each effective ingredient scientific compatibility of component medicine, is a kind of instant effect, has no side effect, Chinese medicine composition that lasts is of a specified duration, and treating both the principal and secondary aspects of a disease, effective percentage is high.
In treatment by Chinese herbs, medicine for external use is compared with oral medicine because it is more convenient, safer, and eliminates Chinese medicine fraud bitter to the taste, more easily by patient is accepted.Because breast belongs to body surface organ, location tables is shallow, and Herbal medicines for external use both can play the therapeutical effect of Chinese medicine, disease of can going directly again institute, drug effect also can be followed breast and reach internal organs through liver meridian, kidney meridian two via meridians, to regulate internal organs negative and positive of qi and blood simultaneously, strengthening vital QI to eliminate pathogenic factors, thus cure diseases.Drug percutaneous skin absorbs, and seldom by liver, also without digestive tract, liver and various digestive enzyme Digestive system can be avoided to destroy the decomposition of ingredient, thus make medicine keep more effective ingredient, play therapeutical effect better; It also avoid some untoward reaction because medicine produces the stimulation of gastrointestinal.Therefore, herbal application method can make up the deficiency of medicine treatment by oral administration of medicines.And easy and simple to handle, patient compliance is good, has unique value for clinical application.
For achieving the above object, the technical solution used in the present invention is as follows:
Be used for the treatment of a pharmaceutical composition for cyclomastopathy and breast tumor, it is prepared by following weight proportioning raw material and obtains,
Fructus Trichosanthis 45 parts, Rhizoma Cyperi 45 parts, Squama Manis 40 parts, the Cortex Eucommiae 40 parts, 35 parts, Poria,
The Radix Angelicae Dahuricae 35 parts, Rhizoma Curcumae 35 parts, Myrrha 30 parts, Rhizoma Sparganii 30 parts, Cortex Moutan 30 parts,
Rhizoma Chuanxiong 25 parts, Olibanum 25 parts, Radix Angelicae Sinensis 25 parts, Herba Houttuyniae 25 parts, Herba Taraxaci 25 parts,
Flos Inulae 20 parts, Fructus Forsythiae 20 parts, 18 parts, Flos Carthami, Herba Pogostemonis 18 parts, Semen Cuscutae 18 parts,
Resina garciniae 15 parts, the Radix Paeoniae Alba 15 parts, Radix Salviae Miltiorrhizae 15 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, Semen Vaccariae 12 parts,
8 parts, Semen Persicae, Galla Chinensis 8 parts, Radix Notoginseng 5 parts, 2 parts, Radix Glycyrrhizae.
The preparation method of described pharmaceutical composition is as follows:
1) each crude drug is taken, for subsequent use;
2) get Rhizoma Cyperi, the Cortex Eucommiae, Poria, Myrrha, Cortex Moutan, Olibanum, Herba Taraxaci, Fructus Forsythiae, Flos Carthami, the Radix Paeoniae Alba, Radix Arnebiae (Radix Lithospermi), Semen Persicae, Radix Glycyrrhizae mix homogeneously, the water intense fire adding 5 times of weight boils, then slow fire boiling 1 hour, collecting by filtration filtrate and filtering residue; In filtering residue, add water, not have filtering residue to be as the criterion, intense fire boiled, then slow fire boiling 1 hour, collecting by filtration filtrate; Merge above-mentioned twice filtrate, after cooling, be condensed into the extractum that density is 1.2g/ml; After 80 DEG C of oven dry, be ground into powder, be complex A;
3) get residual components to add relative to mixture 5 times of weight 75%(v/v) ethanol, reflux, extract, 2 times, each 1 hour, extracting solution merge, be concentrated into the clear paste that density is 1.2g/ml, 80 DEG C of oven dry, pulverizing prepare complex B;
4) complex A and complex B mixing and stirring are obtained active component, by active component conveniently technique make external preparation.
Preferably, described external preparation is gel.
The preparation method of described gel is: active component is added gel-type vehicle, wetting agent etc. and is stirred to dissolve, and makes fully swelling, stirs and prepare gel.
The present invention is foundation with theory of Chinese medical science, and adopt above-mentioned active drug to cooperatively interact prescription, regulate the flow of vital energy, eliminating stagnation, regulating thoroughfare and controlling vessel match, regulating thoroughfare and controlling vessel Zhi Qiben, eliminating stagnation of regulating the flow of vital energy controls its mark, receives that Liver and kidney is ruled together, the effect of reinforcement and elimination in combination, giving consideration to both the incidental and fundamental altogether.Full side's simultaneously using both cold and hot drugs, reinforcement and elimination in combination, makes to attack and but, mends and oiliness, coordination of cold and heat and the gas that do not injure one's stomach, can life-time service, is effective prescription for the treatment of cyclomastopathy liver energy depression and phlegm stagnation card.
According to foregoing, not departing under basic fundamental thought prerequisite of the present invention, according to ordinary technical knowledge and the customary means of this area, the amendment of other various ways, replacement and change obviously can also be made.
Detailed description of the invention
Embodiment 1
Be used for the treatment of a pharmaceutical composition for cyclomastopathy and breast tumor, it is prepared by following weight proportioning raw material and obtains,
Fructus Trichosanthis 45 parts, Rhizoma Cyperi 45 parts, Squama Manis 40 parts, the Cortex Eucommiae 40 parts, 35 parts, Poria,
The Radix Angelicae Dahuricae 35 parts, Rhizoma Curcumae 35 parts, Myrrha 30 parts, Rhizoma Sparganii 30 parts, Cortex Moutan 30 parts,
Rhizoma Chuanxiong 25 parts, Olibanum 25 parts, Radix Angelicae Sinensis 25 parts, Herba Houttuyniae 25 parts, Herba Taraxaci 25 parts,
Flos Inulae 20 parts, Fructus Forsythiae 20 parts, 18 parts, Flos Carthami, Herba Pogostemonis 18 parts, Semen Cuscutae 18 parts,
Resina garciniae 15 parts, the Radix Paeoniae Alba 15 parts, Radix Salviae Miltiorrhizae 15 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, Semen Vaccariae 12 parts,
8 parts, Semen Persicae, Galla Chinensis 8 parts, Radix Notoginseng 5 parts, 2 parts, Radix Glycyrrhizae.
The preparation method of described external preparation is as follows:
1) each crude drug is taken, for subsequent use;
2) get Rhizoma Cyperi, the Cortex Eucommiae, Poria, Myrrha, Cortex Moutan, Olibanum, Herba Taraxaci, Fructus Forsythiae, Flos Carthami, the Radix Paeoniae Alba, Radix Arnebiae (Radix Lithospermi), Semen Persicae, Radix Glycyrrhizae mix homogeneously, the water intense fire adding 5 times of weight boils, then slow fire boiling 1 hour, collecting by filtration filtrate and filtering residue; In filtering residue, add water, not have filtering residue to be as the criterion, intense fire boiled, then slow fire boiling 1 hour, collecting by filtration filtrate; Merge above-mentioned twice filtrate, after cooling, be condensed into the extractum that density is 1.2g/ml; After 80 DEG C of oven dry, be ground into powder, be complex A;
3) get residual components and add ethanol relative to mixture 5 times of weight 75%, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the clear paste that density is 1.2g/ml, 80 DEG C of oven dry, and complex B is prepared in pulverizing;
4) complex A and complex B mixing and stirring are obtained active component, active component, glycerol, water and gelatin are made gel according to the mass ratio of 1:2:3:1.
Embodiment 2
Toxicological study
1 acute toxicity test:
20 rabbit are divided into 2 groups at random, often organize 10, male and female half and half, with 10% sodium sulfide to family's rabbit back depilation, unhairing area is about 150cm
2.The making of damaged skin adopts sterilization ferrum file to scratch (with oozing of blood degree of being), apply active component of the present invention after unhairing respectively, gel is also fixed with nonirritant adhesive plaster in depilation district, every animal sub-cage rearing, administration after 24 hours 1,24,48,72 little of the 7th day, observe every day and record the change of the body weight of animal, fur, gloss, diet, eye and mucosa, the activity of respiratory center, nervous system, extremity and death condition, and put to death rabbit after Yu Qi, the change of the internal organs such as its heart of anatomic observation, liver, spleen, lung, kidney.
Result: the present invention prepares external preparation to the behavior of damaged skin rabbit, activity, diet, fur gloss, respiratory center, nervous system and body weight without any harmful effect, and none rabbit is dead.Rabbit is put to death, the main organs no abnormality seens such as its heart of anatomic observation, liver, spleen, lung, kidney after seven days.Therefore external preparation of the present invention does not all cause acute toxic reaction to rabbit on damaged skin.
2 long term toxicities carry out the chronic toxicity test of 6 months by a definite date to Oral Administration in Rats administration, and overall test results shows that toleration is good.
3 function tests show, external preparation xylol induced mice verification model of the present invention possesses antiinflammatory action, to mouse hot-plate analgesic activity and control drug Huanglianshangqing Tablet group there was no significant difference.
Embodiment 3
Clinical data
Be selected from inpatient's totally 128 examples with complete data.Be divided into treatment group 63 example at random, matched group 65 example.The treatment group age is 35-55 year, 42.5 years old mean age, the matched group age is in 38-54 year, 42.1 years old mean age, age is without statistically-significant difference (p > 0.05), the physical data there was no significant differences such as two groups of Genders, age, courses of disease, have comparability.
Diagnosis basis:
Tcm diagnosis standard:
1) most have a flat lump at the outside upper quadrant of breast, and that lays one's hand on has the tough hard tubercle of beans size, can have tenderness.Lump border owes clear, with surrounding tissue adhesion.;
2) breast can have distending pain, the often growth and decline with susceptible to anger, and the moon of being everlasting is premenstrual to be increased the weight of, and alleviates after menstruation;
3) molybdenum palladium x-ray breast is taken the photograph sheet, cold light source strong illumination, liquid crystal thermography picture etc. inspections and is helped diagnosis.Make histopathological examination if desired, Chong and Ren channel disorder disease CM syndrome differentiation criterion: be more common in middle-aged women.The lump in breast moon is premenstrual to be increased the weight of, through after extenuate.Weak with the soreness of waist, tired, menstruation is imbalance successively, and the few color of amount is light, or amenorrhea.Light red tongue, tongue is white, deep-thready pulse.
Western medicine diagnose standard
1) 35-55 year young women is apt to occur in.
2) symptom: breast has weight distending pain in various degree, twinge, tractive pain or dull pain, and can involve side or bilateral breast, pain, in periodically, changes with menstrual cycle or emotion changes.Some pain is irregular uncorrelated with menstrual cycle, or some is without pain.
3) sign: one or both sides breast can touch single or multiplely to differ in size, form is irregular, matter is tough, obscure boundary lump, has tenderness.Be apt to occur in outside upper quadrant, also dispersible in whole breast breast.Lump is graininess, nodositas, streak or lamellar, not of uniform size, and not etc., obscure boundary, with skin adhesion for soft or hard.
4) nipple discharge: discharge or when touching by certain latex dust system voluntarily, can cause nipple discharge, mostly be white or yellow green, or in slurry.
5) mammary gland color ultrasound is super checks: mammary gland tissue thickens, and fills the air distribution, differs in size, opaque dark area of fluid, and rounded or oval, cyst wall is smooth, and ventilative sound is good, the interstitial Echoenhance between capsule.
6) mammary gland molybdenum palladium x-ray takes the photograph sheet: visible mammary gland presents comparatively uniform density and increases shade, can occur at a quadrant or multiple quadrant.
7) pathological diagnosis: typical cystic hyperplasia of breast pathological change.
Include case standard in:
(1) age 35-55 year, women; (2) in meeting, Western medicine diagnose standard and syndrome CM syndrome differentiation criterion; Drug therapy is not carried out in (3) 3 months; (4) clinical observation " Informed Consent Form " is signed.
Therapeutic Method: the pharmaceutical composition that treatment group adopts the embodiment of the present invention 1 to prepare, preparation is coated on affected part, and is aided with TDP irradiation, each 40 ~ 60 minutes, every day 1 ~ 2 time, within 15 days, be 1 course for the treatment of, have three days off after each course for the treatment of, treat 2 months, equal drug withdrawal in menstrual period, matched group gives Rupisanjie capsule associating tamoxifen oral medication, Rupisanjie capsule 4 tablets/time, 3 times/d; Tamoxifen 10 mg/ time, 2 times/d, menstrual period withdraw, and treat 2 months.
Pain Grading and scoring: 1. mastalgia 0 grade: oncontacting tenderness, remember 6 points without spontaneous pain; Mastalgia 1 grade, presses pain, remembers 12 points without spontaneous pain; 2. mastalgia 2 grades: spontaneous pain, based on premenstrual, becomes paroxysmal to remember 18 points; 3. mastalgia 3 grades: spontaneous pain, in persistence, does not affect life note 24 points; 4. mastalgia 4 grades: spontaneous pain, in persistence, is radiated to oxter, shoulder back, impact life note 30 points.
Lump classification and scoring: 1. 1 grade: matter is soft remembers 3 points as normal body of gland; 2. 2 grades: matter is tough remembers 6 points as nose; 3. 3 grades: matter is firmly as volume remembers 9 points.
The classification of lump scope and scoring (1 breast quadrant is by 1. 5 points): 1. 1 grade: lump distribution is confined to 1 ~ 2 breast quadrant and remembers 3 points; 2. 2 grades: lump distribution is confined to 3 ~ 4 breast quadrants and remembers 6 points; 3. 3 grades: lump distribution is confined to 5 ~ 6 breast quadrants and remembers 9 points; 4. 4 grades: lump distribution is confined to 7 ~ 8 breast quadrants and remembers 12 points.
Tumor size (maximum lump diameter) classification and scoring: 1. 1 grade: lump maximum gauge≤2cm remembers 3 points; 2. 2 grades: lump maximum gauge 2. 1 ~ 5cm remembers 6 points; 3. 3 grades: lump maximum gauge > 5cm remembers 9 points.
Curative effect judging standard: 1. cure: improvement rate >=90%; 2. effective: improvement rate 70% ~ 89%; 3. effective: improvement rate 30% ~ 69%; 4. invalid: improvement rate < 30%.Total mark × 100% before and after integration improvement rate before and after treatment=(before treatment the rear total mark of total mark-treatment)/treatment.Statistical procedures: adopt t inspection between X2 inspection and group, result is as follows:
Table 1 liang group cure rate synopsis
Through X 2 test, two groups of effective percentage compare, and difference has very significant (P<0.01)
Embodiment 4
Model case
Chen, 52 years old, patient's health check-up found lump in breast, and without obvious pain, also aperiodicity change, mobility is poor.Be right side breast tumor through hospital diagnosis, patient's emaciated physique, shortness of breath and palpitation, dim complexion, fatigue and weakness, soreness of the waist and knees.Because of not for being treated surgically, turning the traditional Chinese medical science and curing.Disease is seen through thing disorderly, and premenstrual distending pain of the breast, lump in breast is hard, pale tongue, white and thin fur, stringy and thready pulse.Give pharmaceutical preparation 1 month prepared by the embodiment of the present invention 1, the premenstrual distending pain of the breast of patient alleviates to some extent, and sleep improves.Continue to give Chinese medicine composition of the present invention 1 month, the premenstrual distending pain of the breast of patient disappears, and menstrual cycle is normal, and lump in breast comparatively before reduces.Continue to use 1 course for the treatment of of Chinese medicine composition of the present invention, lump in breast disappears, and all diseases are all removed, and examination in hospital is without difference.Follow up a case by regular visits to 1 year, health is good.
Above-mentioned each Chinese medicine that the present invention adopts makes compatibility mutually, its collaborative effect of curing the disease can be played, there is between each composition of raw material of Chinese medicine used drug effect be interweaved and mutually promote and coordinate usefulness, through clinical verification, there is good therapeutic effect to cyclomastopathy, in the applicant's medical practice for many years, the case Numerous of curing, all obtain good effect, and with low cost, alleviate the burden of patient.
The treatment cyclomastopathy of the application and the Chinese medicine of breast tumor with low cost, evident in efficacy, have broad application prospects.
Claims (3)
1. be used for the treatment of a pharmaceutical composition for cyclomastopathy and breast tumor, it is characterized in that, described pharmaceutical composition is prepared by the raw material of following weight proportioning and obtains,
Fructus Trichosanthis 45 parts, Rhizoma Cyperi 45 parts, Squama Manis 40 parts, the Cortex Eucommiae 40 parts, 35 parts, Poria,
The Radix Angelicae Dahuricae 35 parts, Rhizoma Curcumae 35 parts, Myrrha 30 parts, Rhizoma Sparganii 30 parts, Cortex Moutan 30 parts,
Rhizoma Chuanxiong 25 parts, Olibanum 25 parts, Radix Angelicae Sinensis 25 parts, Herba Houttuyniae 25 parts, Herba Taraxaci 25 parts,
Flos Inulae 20 parts, Fructus Forsythiae 20 parts, 18 parts, Flos Carthami, Herba Pogostemonis 18 parts, Semen Cuscutae 18 parts,
Resina garciniae 15 parts, the Radix Paeoniae Alba 15 parts, Radix Salviae Miltiorrhizae 15 parts, Radix Arnebiae (Radix Lithospermi) 15 parts, Semen Vaccariae 12 parts,
8 parts, Semen Persicae, Galla Chinensis 8 parts, Radix Notoginseng 5 parts, 2 parts, Radix Glycyrrhizae.
2. the preparation method of pharmaceutical composition described in claim 1, is characterized in that, described method comprises the steps:
1) each raw material is taken according to weight proportion, for subsequent use;
2) get Rhizoma Cyperi, the Cortex Eucommiae, Poria, Myrrha, Cortex Moutan, Olibanum, Herba Taraxaci, Fructus Forsythiae, Flos Carthami, the Radix Paeoniae Alba, Radix Arnebiae (Radix Lithospermi), Semen Persicae, Radix Glycyrrhizae, mix homogeneously, the water intense fire adding 5 times of weight boils, then slow fire boiling 1 hour, collecting by filtration filtrate and filtering residue; In filtering residue, add water, not have filtering residue to be as the criterion, intense fire boiled, then slow fire boiling 1 hour, collecting by filtration filtrate; Merge above-mentioned twice filtrate, after cooling, be condensed into the extractum that density is 1.2g/ml; After 80 DEG C of oven dry, be ground into powder, be complex A;
3) get surplus stock mixing, add the ethanol relative to mixture 5 times of weight 75%, reflux, extract, 2 times, each 1 hour, extracting solution merges, and is concentrated into the clear paste that density is 1.2g/mL, 80 DEG C of oven dry, pulverizes and prepares complex B;
4) by complex A and complex B mixing and stirring and get final product.
3. pharmaceutical composition described in claim 1-2 is used for the medicinal usage of mastopathy.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108079246A (en) * | 2017-12-20 | 2018-05-29 | 广州傲雅威代生物科技有限公司 | A kind of medium-height grass medicinal gel and preparation method thereof |
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| CN101455808A (en) * | 2008-11-11 | 2009-06-17 | 路佃俊 | External medicine for treating hyperplasia of mammary glands |
| CN102380083A (en) * | 2011-11-15 | 2012-03-21 | 梁淑花 | External plaster for treating mammary gland hyperplasia and lactation mastitis |
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| CN108079246A (en) * | 2017-12-20 | 2018-05-29 | 广州傲雅威代生物科技有限公司 | A kind of medium-height grass medicinal gel and preparation method thereof |
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Application publication date: 20150520 |