CN104721737A - External preparation for hyperplasia of mammary glands - Google Patents
External preparation for hyperplasia of mammary glands Download PDFInfo
- Publication number
- CN104721737A CN104721737A CN201510103896.0A CN201510103896A CN104721737A CN 104721737 A CN104721737 A CN 104721737A CN 201510103896 A CN201510103896 A CN 201510103896A CN 104721737 A CN104721737 A CN 104721737A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- external preparation
- cyclomastopathy
- rhizoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to an external preparation for hyperplasia of mammary glands. The external preparation is prepared from the following raw materials in parts by weight: 40 parts of rhizoma cyperi, 40 parts of snakegourd fruit, 35 parts of pangolin, 35 parts of eucommia ulmoides, 30 parts of poria cocos, 30 parts of radix angelicae, 30 parts of curcuma zedoary, 25 parts of myrrh, 25 parts of rhizoma sparganii, 25 parts of paeonia suffruticosa, 20 parts of ligusticum wallichii, 20 parts of olibanum, 20 parts of angelica sinensis, 20 parts of houttuynia cordata, 20 parts of dandelion, 18 parts of inula flower, 18 parts of fructus forsythia, 15 parts of flos carthami, 15 parts of agastache rugosus, 15 parts of semen cuscutae, 12 parts of gamboges, 12 parts of white paeony root, 10 parts of salviae miltiorrhizae, 10 parts of shikonin, 10 parts of cowherb seeds, 5 parts of peach kernel, 5 parts of Chinese gall, 5 parts of panax notoginseng and 5 parts of liquorice. The external preparation for hyperplasia of mammary glands is capable of treating both symptoms and root causes, is nontoxic and harmless on a human body, free of a side effect, low in price, and simple and convenient to prepare, and has a wide application prospect.
Description
Technical field
The invention belongs to field of Chinese medicine, concrete, relate to a kind of external preparation for cyclomastopathy.
Background technology
Cyclomastopathy is also known as mammary dysplasia, fibrocystic disease of breast, it is a kind of disease of comprehensive various clinical disease, comprise mammoplasia's disease (mastalgia), adenosis of breast, cystic cyclomastopathy etc., cyclomastopathy is commonly encountered diseases, the frequently-occurring disease of young women, its sickness rate occupies mastopathy first place, accounts for 60% ~ 70%.Main manifestations is distending pain of the breast and breast caking, and how to change with menstrual cycle or feelings will and to change.Age of onset can be any adult female, wherein 30-40 year occurred frequently, the sickness rate of Women of childbearing age is 40%, accounts for mastotic 2/3, in recent years in obvious ascendant trend.The canceration rate of cyclomastopathy patient is about the 1.5-2 of general population doubly, and wherein atypical hyperplasia is 5 times, and therefore this disease has a strong impact on women's health, and control receives the concern of country, society, academia.
Cyclomastopathy is the disorder of the mammary gland normal configuration that a kind of physiology hypertrophy and subinvolution cause in essence, clinical with lump in breast and mastalgia for principal character, symptom generally normal in premenstruum increase the weight of, pass through after alleviate.This sick sickness rate is in ascendant trend year by year in recent years, and has the tendency that becomes younger.The dangerous compared with normal women that primary disease cancerates increases 2-4 doubly, and clinical symptoms and sign are easily mixed with cyclomastopathy sometimes mutually.During this onste, patient is anxious because of lump in breast pain, and work and life are had a strong impact on, therefore give early treatment to this disease energetically, no matter at disease therapy itself, or in control canceration, all has very important significance.
Modern medicine is still very not clear at present to the etiology and pathogenesis of this disease, and most scholar thinks that this disease and endocrine function are lacked of proper care relevant with Nervous and Mental Factors, and it is this pathogenetic major reason that Progesterone secretion reduces increase relative with estrogen.Drug therapy is based on hormones preparation, although short-term effect is good, can obvious relief of symptoms, but curative effect is unstable, easily recurs after drug withdrawal, prolonged application can disturb the balance between human hormone, cause the side effect such as menoxenia, secondary sex characteristics change, and have the risk increasing canceration, therefore generally as routine administration, only should not consider application when serious symptom.Operative therapy is applicable to the patient that severe hypertrophy has the tendency that cancerates, but easily causes body to damage, and very easily recurs.How undesirable endo-medicine curative effect is also.There is no the specific medicament of this disease for the treatment of at present.
Motherland's medical science thinks that this disease belongs to traditional Chinese medical science “ Ru Repair-in ", " newborn painful abdominal mass ", " nodule in the breast " category; its morbidity is relevant with the many factors such as feelings will, fatigue, diet, body constitution; pathogenesis key is that qi depression to blood stasis, phlegm-damp condense, while with the internal organs such as liver spleen kidney and to rush wantonly two arteries and veins in close relations.The traditional Chinese medical science by dialectical treat treatment primary disease long-standing, the Therapeutic Method of clinical accumulation and more for the treatment of means disappear except sheet, serial Chinese patent medicine such as newborn disease spirit granule, RUKUAIXIAO PIAN etc. Chu Ru Repair-in, also have a large amount of folk prescription, proved recipe, acupuncture, massage, cupping jar, magnetic medicine chest protecting device etc.Facts have proved, tcm therapy Be very effective, few side effects, with Western medicine share also can attenuation synergistic, reduce relapse rate.
Prior art is in the treatment of cyclomastopathy, and Western medicine side effect causes anxiety, and Chinese medicine is comparatively conventional, but can effective lenitive Chinese patent medicine kind few, curative effect is not satisfactory.In view of the market demand of this sick medicine is very large, pole is necessary the Chinese patent medicine preparation developing new determined curative effect, for clinician provides more medication to select.Using Chinese medicine to alleviate mammary gland pain and tuberosity is widely used Therapeutic Method clinically at present, and Chinese medicine directly can be imposed on affected part by external treatment of tcm, and by Transdermal absorption, the efficacy of a drug is gone directly disease institute, thus improves bioavailability.At present, the medicine for the treatment of cyclomastopathy is a lot, but for various reasons, and it uses and curative effect unsatisfactory, therefore explores safer and more effective medicine and just seems very urgent.
Summary of the invention
The technical problem to be solved in the present invention is for providing a kind of patient's of alleviating misery, more effectively treating the Chinese medicine preparation of cyclomastopathy, liver energy depression and phlegm stagnation card is belonged to for cyclomastopathy, disease sees that lump in breast matter is tough slightly hard, and size, form differ, irascible temperament or depression, side of body feeling of distension and oppression is uncomfortable, lump in breast size or can increase and decrease with susceptible to anger, or relevant to menstruation, light red tongue, greasy fur, stringy pulse; Companion's person with Spleen Deficiency, doublely can see that lack of appetite is indigestion and loss of appetite, abdominal distention after meal, spiritlessness and sparing of words, insomnia; If singly see stagnation of liver-QI and expectorant coagulates not obvious person, then visible two side of body distending pains, irritable, dimly pale tongue, tongue is white, stringy pulse.The present invention is used for the external preparation energy treating both the principal and secondary aspects of a disease of cyclomastopathy, and safely, effectively, medical expense is lower.
The present invention combines clinical experience for many years on the basis of traditional medicine, by the research to Chinese medicine, and in conjunction with dialectical demonstration, in many ways collects soothing the liver eliminating stagnation, the natural Chinese medicine of the chest stuffiness relieving of regulating the flow of vital energy, menstruction regulating and pain relieving, adopts modern processing method meticulously to develop.The present invention, to each effective ingredient scientific compatibility of component medicine, is a kind of instant effect, has no side effect, Chinese medicine composition that lasts is of a specified duration, and treating both the principal and secondary aspects of a disease, effective percentage is high.
In treatment by Chinese herbs, medicine for external use is compared with oral medicine because it is more convenient, safer, and eliminates Chinese medicine fraud bitter to the taste, more easily by patient is accepted.Because breast belongs to body surface organ, location tables is shallow, and Herbal medicines for external use both can play the therapeutical effect of Chinese medicine, disease of can going directly again institute, drug effect also can be followed breast and reach internal organs through liver meridian, kidney meridian two via meridians, to regulate internal organs negative and positive of qi and blood simultaneously, strengthening vital QI to eliminate pathogenic factors, thus cure diseases.Drug percutaneous skin absorbs, and seldom by liver, also without digestive tract, liver and various digestive enzyme Digestive system can be avoided to destroy the decomposition of ingredient, thus make medicine keep more effective ingredient, play therapeutical effect better; It also avoid some untoward reaction because medicine produces the stimulation of gastrointestinal.Therefore, herbal application method can make up the deficiency of medicine treatment by oral administration of medicines.And easy and simple to handle, patient compliance is good, has unique value for clinical application.
For achieving the above object, the technical solution used in the present invention is as follows:
For an external preparation for cyclomastopathy, it is prepared by following weight proportioning raw material and obtains,
Rhizoma Cyperi 40 parts, Fructus Trichosanthis 40 parts, Squama Manis 35 parts, the Cortex Eucommiae 35 parts, 30 parts, Poria,
The Radix Angelicae Dahuricae 30 parts, Rhizoma Curcumae 30 parts, Myrrha 25 parts, Rhizoma Sparganii 25 parts, Cortex Moutan 25 parts,
Rhizoma Chuanxiong 20 parts, Olibanum 20 parts, Radix Angelicae Sinensis 20 parts, Herba Houttuyniae 20 parts, Herba Taraxaci 20 parts,
Flos Inulae 18 parts, Fructus Forsythiae 18 parts, 15 parts, Flos Carthami, Herba Pogostemonis 15 parts, Semen Cuscutae 15 parts,
Resina garciniae 12 parts, the Radix Paeoniae Alba 12 parts, Radix Salviae Miltiorrhizae 10 parts, Radix Arnebiae (Radix Lithospermi) 10 parts, Semen Vaccariae 10 parts,
5 parts, Semen Persicae, Galla Chinensis 5 parts, Radix Notoginseng 5 parts, 5 parts, Radix Glycyrrhizae.
The preparation method of described external preparation is as follows:
1) each crude drug is taken according to weight proportion, for subsequent use;
2) get Rhizoma Cyperi, the Cortex Eucommiae, Poria, Myrrha, Cortex Moutan, Olibanum, Herba Taraxaci, Fructus Forsythiae, Flos Carthami, the Radix Paeoniae Alba, Radix Arnebiae (Radix Lithospermi), Semen Persicae, Radix Glycyrrhizae mix homogeneously, the water intense fire adding 5 times of weight boils, then slow fire boiling 1 hour, collecting by filtration filtrate and filtering residue; In filtering residue, add water, not have filtering residue to be as the criterion, intense fire boiled, then slow fire boiling 1 hour, collecting by filtration filtrate; Merge above-mentioned twice filtrate, after cooling, be condensed into the extractum that density is 1.2g/ml; After 80 DEG C of oven dry, be ground into powder, be complex A;
3) get residual components to add relative to mixture 5 times of weight 75%(v/v) ethanol, reflux, extract, 2 times, each 1 hour, extracting solution merge, be concentrated into the clear paste that density is 1.2g/ml, 80 DEG C of oven dry, pulverizing prepare complex B;
4) complex A and complex B mixing and stirring are obtained active component, by active component conveniently technique make external preparation.
Preferably, described external preparation is gel.
The preparation method of described gel is: active component is added gel-type vehicle, wetting agent stirs and prepare gel.
The present invention is foundation with theory of Chinese medical science, and adopt above-mentioned active drug to cooperatively interact prescription, regulate the flow of vital energy, eliminating stagnation, regulating thoroughfare and controlling vessel match, regulating thoroughfare and controlling vessel Zhi Qiben, eliminating stagnation of regulating the flow of vital energy controls its mark, receives that Liver and kidney is ruled together, the effect of reinforcement and elimination in combination, giving consideration to both the incidental and fundamental altogether.Full side's simultaneously using both cold and hot drugs, reinforcement and elimination in combination, makes to attack and but, mends and oiliness, coordination of cold and heat and the gas that do not injure one's stomach, can life-time service, is the effective prescription for the treatment of cyclomastopathy.
According to foregoing, not departing under basic fundamental thought prerequisite of the present invention, according to ordinary technical knowledge and the customary means of this area, the amendment of other various ways, replacement and change obviously can also be made.
Detailed description of the invention
Embodiment 1
For an external preparation for cyclomastopathy, it is prepared by following weight proportioning raw material and obtains,
Rhizoma Cyperi 40 parts, Fructus Trichosanthis 40 parts, Squama Manis 35 parts, the Cortex Eucommiae 35 parts, 30 parts, Poria,
The Radix Angelicae Dahuricae 30 parts, Rhizoma Curcumae 30 parts, Myrrha 25 parts, Rhizoma Sparganii 25 parts, Cortex Moutan 25 parts,
Rhizoma Chuanxiong 20 parts, Olibanum 20 parts, Radix Angelicae Sinensis 20 parts, Herba Houttuyniae 20 parts, Herba Taraxaci 20 parts,
Flos Inulae 18 parts, Fructus Forsythiae 18 parts, 15 parts, Flos Carthami, Herba Pogostemonis 15 parts, Semen Cuscutae 15 parts,
Resina garciniae 12 parts, the Radix Paeoniae Alba 12 parts, Radix Salviae Miltiorrhizae 10 parts, Radix Arnebiae (Radix Lithospermi) 10 parts, Semen Vaccariae 10 parts,
5 parts, Semen Persicae, Galla Chinensis 5 parts, Radix Notoginseng 5 parts, 5 parts, Radix Glycyrrhizae.
The preparation method of described external preparation is as follows:
1) each crude drug is taken, for subsequent use;
2) get Rhizoma Cyperi, the Cortex Eucommiae, Poria, Myrrha, Cortex Moutan, Olibanum, Herba Taraxaci, Fructus Forsythiae, Flos Carthami, the Radix Paeoniae Alba, Radix Arnebiae (Radix Lithospermi), Semen Persicae, Radix Glycyrrhizae, mix homogeneously, the water intense fire adding 5 times of weight boils, then slow fire boiling 1 hour, collecting by filtration filtrate and filtering residue; In filtering residue, add water, not have filtering residue to be as the criterion, intense fire boiled, then slow fire boiling 1 hour, collecting by filtration filtrate; Merge above-mentioned twice filtrate, after cooling, be condensed into the extractum that density is 1.2g/ml; After 80 DEG C of oven dry, be ground into powder, be complex A;
3) get residual components to add relative to mixture 5 times of weight 75%(v/v) ethanol, reflux, extract, 2 times, each 1 hour, extracting solution merge, be concentrated into the clear paste that density is 1.2g/ml, 80 DEG C of oven dry, pulverizing prepare complex B;
4) complex A and complex B mixing and stirring are obtained active component, active component, glycerol, water and gelatin are made gel according to the mass ratio of 1:2:3:1.
Embodiment 2
Toxicological study
1 acute toxicity test:
20 rabbit are divided into 2 groups at random, often organize 10, male and female half and half, with 10% sodium sulfide to family's rabbit back depilation, unhairing area is about 150cm
2.The making of damaged skin adopts sterilization ferrum file to scratch (with oozing of blood degree of being), apply active component of the present invention after unhairing respectively, gel is also fixed with nonirritant adhesive plaster in depilation district, every animal sub-cage rearing, administration after 24 hours 1,24,48,72 little of the 7th day, observe every day and record the change of the body weight of animal, fur, gloss, diet, eye and mucosa, the activity of respiratory center, nervous system, extremity and death condition, and put to death rabbit after Yu Qi, the change of the internal organs such as its heart of anatomic observation, liver, spleen, lung, kidney.
Result: the present invention prepares external preparation to the behavior of damaged skin rabbit, activity, diet, fur gloss, respiratory center, nervous system and body weight without any harmful effect, and none rabbit is dead.Rabbit is put to death, the main organs no abnormality seens such as its heart of anatomic observation, liver, spleen, lung, kidney after seven days.Therefore external preparation of the present invention does not all cause acute toxic reaction to rabbit on damaged skin.
2 long term toxicities carry out the chronic toxicity test of 6 months by a definite date to Oral Administration in Rats administration, and overall test results shows that toleration is good.
3 function tests show, external preparation xylol induced mice verification model of the present invention possesses antiinflammatory action, to mouse hot-plate analgesic activity and control drug Huanglianshangqing Tablet group there was no significant difference.
Clinical data
Be selected from inpatient's totally 130 examples with complete data.Be divided into treatment group 65 example at random, matched group 65 example.The treatment group age is 39-55 year, 41.7 years old mean age, the matched group age is in 38-54 year, 42.1 years old mean age, age is without statistically-significant difference (p > 0.05), the physical data there was no significant differences such as two groups of Genders, age, courses of disease, have comparability.
Diagnosis basis:
Tcm diagnosis standard:
1) most have a flat lump at the outside upper quadrant of breast, and that lays one's hand on has the tough hard tubercle of beans size, can have tenderness, and lump border owes clear, with surrounding tissue adhesion.;
2) breast can have distending pain, the often growth and decline with susceptible to anger, and the moon of being everlasting is premenstrual to be increased the weight of, and alleviates after menstruation;
3) molybdenum palladium x-ray breast is taken the photograph sheet, cold light source strong illumination, liquid crystal thermography picture etc. inspections and is helped diagnosis.Make histopathological examination if desired, Chong and Ren channel disorder disease CM syndrome differentiation criterion: be more common in middle-aged women.The lump in breast moon is premenstrual to be increased the weight of, through after extenuate.Weak with the soreness of waist, tired, menstruation is imbalance successively, and the few color of amount is light, or amenorrhea.Light red tongue, tongue is white, deep-thready pulse.
Western medicine diagnose standard
1) 35-55 year young women is apt to occur in.
2) symptom: breast has weight distending pain in various degree, twinge, tractive pain or dull pain, and can involve side or bilateral breast, pain, in periodically, changes with menstrual cycle or emotion changes.Some pain is irregular uncorrelated with menstrual cycle, or some is without pain.
3) sign: one or both sides breast can touch single or multiplely to differ in size, form is irregular, matter is tough, obscure boundary lump, has tenderness.Be apt to occur in outside upper quadrant, also dispersible in whole breast breast.Lump is graininess, nodositas, streak or lamellar, not of uniform size, and not etc., obscure boundary, with skin adhesion for soft or hard.
4) nipple discharge: discharge or when touching by certain latex dust system voluntarily, can cause nipple discharge, mostly be white or yellow green, or in slurry.
5) mammary gland color ultrasound is super checks: mammary gland tissue thickens, and fills the air distribution, differs in size, opaque dark area of fluid, and rounded or oval, cyst wall is smooth, and ventilative sound is good, the interstitial Echoenhance between capsule.
6) mammary gland molybdenum palladium x-ray takes the photograph sheet: visible mammary gland presents comparatively uniform density and increases shade, can occur at a quadrant or multiple quadrant.
7) pathological diagnosis: typical cystic hyperplasia of breast pathological change.
Include case standard in:
(1) age 35-55 year, women; (2) in meeting, Western medicine diagnose standard and syndrome CM syndrome differentiation criterion; Drug therapy is not carried out in (3) 3 months; (4) clinical observation " Informed Consent Form " is signed.
Therapeutic Method: the Chinese medicine preparation that treatment group adopts the embodiment of the present invention 1 to prepare, preparation is coated on affected part, and is aided with TDP irradiation, each 40 ~ 60 minutes, every day 1 ~ 2 time, within 15 days, be 1 course for the treatment of, have three days off after each course for the treatment of, treat 2 months, equal drug withdrawal in menstrual period, matched group gives Rupisanjie capsule associating tamoxifen oral medication, Rupisanjie capsule 4 tablets/time, 3 times/d; Tamoxifen 10 mg/ time, 2 times/d, menstrual period withdraw, and treat 2 months.
Pain Grading and scoring: 1. mastalgia 0 grade: oncontacting tenderness, remember 6 points without spontaneous pain; Mastalgia 1 grade, presses pain, remembers 12 points without spontaneous pain; 2. mastalgia 2 grades: spontaneous pain, based on premenstrual, becomes paroxysmal to remember 18 points; 3. mastalgia 3 grades: spontaneous pain, in persistence, does not affect life note 24 points; 4. mastalgia 4 grades: spontaneous pain, in persistence, is radiated to oxter, shoulder back, impact life note 30 points.
Lump classification and scoring: 1. 1 grade: matter is soft remembers 3 points as normal body of gland; 2. 2 grades: matter is tough remembers 6 points as nose; 3. 3 grades: matter is firmly as volume remembers 9 points.
The classification of lump scope and scoring (1 breast quadrant is by 1. 5 points): 1. 1 grade: lump distribution is confined to 1 ~ 2 breast quadrant and remembers 3 points; 2. 2 grades: lump distribution is confined to 3 ~ 4 breast quadrants and remembers 6 points; 3. 3 grades: lump distribution is confined to 5 ~ 6 breast quadrants and remembers 9 points; 4. 4 grades: lump distribution is confined to 7 ~ 8 breast quadrants and remembers 12 points.
Tumor size (maximum lump diameter) classification and scoring: 1. 1 grade: lump maximum gauge≤2cm remembers 3 points; 2. 2 grades: lump maximum gauge 2. 1 ~ 5cm remembers 6 points; 3. 3 grades: lump maximum gauge > 5cm remembers 9 points.
Curative effect judging standard: 1. cure: improvement rate >=90%; 2. effective: improvement rate 70% ~ 89%; 3. effective: improvement rate 30% ~ 69%; 4. invalid: improvement rate < 30%.Total mark × 100% before and after integration improvement rate before and after treatment=(before treatment the rear total mark of total mark-treatment)/treatment.Statistical procedures: adopt t inspection between X2 inspection and group, result is as follows:
Table 1 liang group cure rate synopsis
Through X 2 test, two groups of effective percentage compare, and difference has very significant (P<0.01)
Above-mentioned each Chinese medicine that the present invention adopts makes compatibility mutually, its collaborative effect of curing the disease can be played, there is between each composition of raw material of Chinese medicine used drug effect be interweaved and mutually promote and coordinate usefulness, through clinical verification, there is good therapeutic effect to cyclomastopathy, in the applicant's medical practice for many years, the case Numerous of curing, all obtain good effect, and with low cost, alleviate the burden of patient.
The Chinese medicine of the treatment cyclomastopathy of the application is with low cost, evident in efficacy, has broad application prospects.
Claims (3)
1. for an external preparation for cyclomastopathy, it is characterized in that, described preparation is prepared by following weight proportioning raw material and obtains,
Rhizoma Cyperi 40 parts, Fructus Trichosanthis 40 parts, Squama Manis 35 parts, the Cortex Eucommiae 35 parts, 30 parts, Poria,
The Radix Angelicae Dahuricae 30 parts, Rhizoma Curcumae 30 parts, Myrrha 25 parts, Rhizoma Sparganii 25 parts, Cortex Moutan 25 parts,
Rhizoma Chuanxiong 20 parts, Olibanum 20 parts, Radix Angelicae Sinensis 20 parts, Herba Houttuyniae 20 parts, Herba Taraxaci 20 parts,
Flos Inulae 18 parts, Fructus Forsythiae 18 parts, 15 parts, Flos Carthami, Herba Pogostemonis 15 parts, Semen Cuscutae 15 parts,
Resina garciniae 12 parts, the Radix Paeoniae Alba 12 parts, Radix Salviae Miltiorrhizae 10 parts, Radix Arnebiae (Radix Lithospermi) 10 parts, Semen Vaccariae 10 parts,
5 parts, Semen Persicae, Galla Chinensis 5 parts, Radix Notoginseng 5 parts, 5 parts, Radix Glycyrrhizae.
2. according to claim 1 for the preparation method of the external preparation of cyclomastopathy, it is characterized in that, described method comprises the steps:
1) each raw material is taken according to weight proportion, for subsequent use;
2) get Rhizoma Cyperi, the Cortex Eucommiae, Poria, Myrrha, Cortex Moutan, Olibanum, Herba Taraxaci, Fructus Forsythiae, Flos Carthami, the Radix Paeoniae Alba, Radix Arnebiae (Radix Lithospermi), Semen Persicae, Radix Glycyrrhizae, mix homogeneously, the water intense fire adding 5 times of weight boils, then slow fire boiling 1 hour, collecting by filtration filtrate and filtering residue; In filtering residue, add water, not have filtering residue to be as the criterion, intense fire boiled, then slow fire boiling 1 hour, collecting by filtration filtrate; Merge above-mentioned twice filtrate, after cooling, be condensed into the extractum that density is 1.2g/ml; After 80 DEG C of oven dry, be ground into powder, be complex A;
3) get surplus stock, mixing, adds the ethanol relative to mixture 5 times of weight 75%, reflux, extract, 2 times, each 1 hour, and extracting solution merges, and is concentrated into the clear paste that density is 1.2g/ml, 80 DEG C of oven dry, pulverizes obtained complex B;
4) complex A and complex B mixing and stirring are obtained active component, active component is made external preparation.
3. preparation described in claim 1-2 is used for the medicinal usage of cyclomastopathy.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510103896.0A CN104721737A (en) | 2015-03-10 | 2015-03-10 | External preparation for hyperplasia of mammary glands |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510103896.0A CN104721737A (en) | 2015-03-10 | 2015-03-10 | External preparation for hyperplasia of mammary glands |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104721737A true CN104721737A (en) | 2015-06-24 |
Family
ID=53446533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510103896.0A Pending CN104721737A (en) | 2015-03-10 | 2015-03-10 | External preparation for hyperplasia of mammary glands |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104721737A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105853913A (en) * | 2016-04-28 | 2016-08-17 | 张传水 | External plaster for treating hyperplasia of mammary glands |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101116738A (en) * | 2006-08-01 | 2008-02-06 | 青岛市市立医院 | Chinese traditional medicine for treating mammary gland hyperplasia and method for preparing the same |
| CN102058826A (en) * | 2009-11-16 | 2011-05-18 | 刘振平 | Ointment for treating cyclomastopathy |
| US20110268719A1 (en) * | 2003-04-08 | 2011-11-03 | American River Nutrition, Inc. | Annatto Extract Compositions, Including Geranyl Geraniols And Methods Of Use |
| CN104189756A (en) * | 2014-09-09 | 2014-12-10 | 韩世昌 | Traditional Chinese medicinal ointment for treating hyperplasia of mammary glands and preparation method thereof |
-
2015
- 2015-03-10 CN CN201510103896.0A patent/CN104721737A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110268719A1 (en) * | 2003-04-08 | 2011-11-03 | American River Nutrition, Inc. | Annatto Extract Compositions, Including Geranyl Geraniols And Methods Of Use |
| CN101116738A (en) * | 2006-08-01 | 2008-02-06 | 青岛市市立医院 | Chinese traditional medicine for treating mammary gland hyperplasia and method for preparing the same |
| CN102058826A (en) * | 2009-11-16 | 2011-05-18 | 刘振平 | Ointment for treating cyclomastopathy |
| CN104189756A (en) * | 2014-09-09 | 2014-12-10 | 韩世昌 | Traditional Chinese medicinal ointment for treating hyperplasia of mammary glands and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 李菊华等: "《难治妇科病名医绝技》", 30 April 2012 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105853913A (en) * | 2016-04-28 | 2016-08-17 | 张传水 | External plaster for treating hyperplasia of mammary glands |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102908603B (en) | Chinese medicament for treating hyperplasia of mammary glands | |
| CN103071128B (en) | Externally-applied plaster for curing dysmenorrhea | |
| CN102940853B (en) | Navel paste for treating mammary gland hyperplasia diseases | |
| CN102580000B (en) | Medicament for curing cancer pain and preparation method thereof | |
| CN104474380B (en) | It is a kind of to treat Chinese medicine of cyclomastopathy and preparation method thereof | |
| CN103705641A (en) | Traditional Chinese medicine composition for treating oligospermia and asthenozoospermia | |
| CN103272143A (en) | Traditional Chinese medicine composition for treating acne | |
| CN103341092B (en) | Preparation method of powder for treating atrophic vaginitis | |
| CN103356932B (en) | A kind of pharmaceutical composition for the treatment of vulva squamous epithelial hyperplasia | |
| CN103394030B (en) | Traditional Chinese medicine composition for treating depressed liver and deficient spleen | |
| CN103285284B (en) | Medical composition for treating senile vaginitis | |
| CN103301353B (en) | Pharmaceutical composition for treating atrophic vaginitis | |
| CN103083616B (en) | Traditional Chinese medicine for treating ovarian cyst | |
| CN102755515B (en) | Traditional Chinese medicine decoction for treating hyperplasia of mammary glands | |
| CN104257977A (en) | Traditional Chinese medicine preparation for treating liver-stomach disharmony type chronic superficial gastritis | |
| CN103585609A (en) | Traditional Chinese medicine composition for treating dysmenorrhea and preparation method thereof | |
| CN104721737A (en) | External preparation for hyperplasia of mammary glands | |
| CN102940716A (en) | Traditional Chinese medicine for treatment of uterine prolapse | |
| CN104623562A (en) | Pharmaceutical composition for treating hyperplasia of mammary glands and breast tumors | |
| CN103212013B (en) | Chinese medicinal composition for treating epigastric pain | |
| CN103330867B (en) | Preparation method of powder for treating senile vaginitis | |
| CN105853930A (en) | Traditional Chinese medicine composition for treating depression | |
| CN101396534B (en) | Traditional Chinese medicine for treating lobular hyperplasia of mammary gland | |
| CN110051812A (en) | A kind of strengthening vital QI to eliminate pathogenic factors Chinese medicine and preparation method thereof | |
| CN103330896B (en) | Preparation method of powder for treating postpartum nonspecific vaginitis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150624 |
|
| RJ01 | Rejection of invention patent application after publication |