CN108056226A - It is a kind of that there is additive for adjusting pet functions of intestines and stomach and its preparation method and application - Google Patents
It is a kind of that there is additive for adjusting pet functions of intestines and stomach and its preparation method and application Download PDFInfo
- Publication number
- CN108056226A CN108056226A CN201810012802.2A CN201810012802A CN108056226A CN 108056226 A CN108056226 A CN 108056226A CN 201810012802 A CN201810012802 A CN 201810012802A CN 108056226 A CN108056226 A CN 108056226A
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- lactobacillus acidophilus
- chinese yam
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- 230000000996 additive effect Effects 0.000 title claims abstract description 57
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- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 230000006870 function Effects 0.000 title claims abstract description 17
- 239000000843 powder Substances 0.000 claims abstract description 60
- 240000001046 Lactobacillus acidophilus Species 0.000 claims abstract description 37
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 claims abstract description 37
- 229940039695 lactobacillus acidophilus Drugs 0.000 claims abstract description 37
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Classifications
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- A—HUMAN NECESSITIES
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- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
- A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/113—Acidophilus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
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- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
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- Alternative & Traditional Medicine (AREA)
- Animal Husbandry (AREA)
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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- Biomedical Technology (AREA)
Abstract
The present invention provides a kind of additives and preparation method and application for having and adjusting pet functions of intestines and stomach, belong to technical field of animal.It is described that there is the additive for adjusting pet functions of intestines and stomach, include the component of following parts by weight：2~10 parts of lactobacillus acidophilus powder, 1~5 part of hawthorn, 2~10 parts of Chinese yam, 2~10 parts of Poria cocos, 1~5 part of Radix Glycyrrhizae, 1~5 part of dried orange peel；The viable bacteria concentration of the lactobacillus acidophilus powder is 0.5 × 1010~1.5 × 1010CFU/g.Additive provided by the invention can be obviously improved the anti-stress ability of weaning stage puppy, adjust gastrointestinal function, experiment show experimental group compared with the control group illness rate, appetite, coat gloss, activity, daily gain, intestinal flora composition on is significantly improved, and with Chinese yam, tuckahoe lack taste group in illness rate, appetite, coat gloss, activity, daily gain there were significant differences.
Description
Technical field
The invention belongs to technical field of animal, and in particular to it is a kind of have adjust pet functions of intestines and stomach additive and
Its preparation method and application.
Background technology
It keeps a pet as the improvement of people's living standards, more and more people like, especially the elderly, at one's side without child
The company of son, it is also the lonely one good medicine of resolution to keep a pet.Keep a pet for people is natural mood regulation agent and cat
Dog together, can not only clear up loneliness, can also ease off the pressure.However pet, as the mankind or other animals, meeting is usually
With disease, and stomach disease be pet cat or pet dog it occur frequently that disease.
It is more to be presently used for adjusting the feed for pet species of stomach, for example, the patent of Publication No. CN 105192421A
A kind of dog food for protecting stomach is disclosed, specifically by fish, meat, greengrocery, fruits, seaweeds, inorganic salts and vegetable oil
Class form, by improve pet immunity and enterogastritis generation so as to achieve the purpose that adjust stomach.But the pet is raised
The effect curative effect of material is not notable, and is of limited application, and is not suitable for new life pet or has occurred and that the pet of gastrointestinal disease.
The content of the invention
In view of this, there is the additive for adjusting pet functions of intestines and stomach and its preparation it is an object of the invention to provide a kind of
Methods and applications, the additive adjustment effect is notable, and application range is wider.
In order to realize foregoing invention purpose, the present invention provides following technical scheme：
The present invention provides a kind of additives for having and adjusting pet functions of intestines and stomach, include the components of following parts by weight：It is thermophilic
2~10 parts of Lactobacillus lactis powder, 1~5 part of hawthorn, 2~10 parts of Chinese yam, 2~10 parts of Poria cocos, 1~5 part of Radix Glycyrrhizae, 1~5 part of dried orange peel；Institute
The viable bacteria concentration for stating lactobacillus acidophilus is 0.5 × 1010~1.5 × 1010CFU/g。
Preferably, the component of following parts by weight is included：4~8 parts of lactobacillus acidophilus powder, 2~4 parts of hawthorn, 4~8 parts of Chinese yam,
4~8 parts of Poria cocos, 2~4 parts of Radix Glycyrrhizae, 2~4 parts of dried orange peel.
Preferably, the component of following parts by weight is included：6 parts of lactobacillus acidophilus powder, 3 parts of hawthorn, 6 parts of Chinese yam, 6 parts of Poria cocos,
3 parts of Radix Glycyrrhizae, 3 parts of dried orange peel.
Preferably, the viable bacteria concentration of the lactobacillus acidophilus powder is 1 × 1010CFU/g。
Preferably, the dosage form of the additive is granule；
The granule includes the auxiliary material of 1~3 parts by weight；
The auxiliary material is one or more of in maltodextrin, dextrin, starch, mannitol and lactose.
The present invention provides the preparation methods of the additive for having and adjusting pet functions of intestines and stomach, comprise the following steps：
1) hawthorn, Chinese yam, Poria cocos, Radix Glycyrrhizae and dried orange peel are crushed, sieves, obtain herb powder；
2) herb powder is sterilized, the herb powder to be sterilized；
3) herb powder of the sterilizing with lactobacillus acidophilus powder is mixed, obtains additive.
Preferably, when the dosage form of the additive is granule, the additive further includes auxiliary material, the step 3)
For：By the herb powder of middle sterilizing and auxiliary material mixing granulation, obtained Chinese medicinal granule is mixed with lactobacillus acidophilus powder, added again
Add agent.
Preferably, the aperture of the sieving is 70~100 mesh.
Additive prepared by the additive provided by the invention or the method is preparing prevention or treatment pet intestines
Application in tract disease drug.
Additive prepared by the additive provided by the invention or the method is preparing adjusting pet function of intestinal canal
Application in health products.
The present invention provides a kind of additives for having and adjusting pet functions of intestines and stomach, include the components of following parts by weight：It is thermophilic
2~10 parts of Lactobacillus lactis, 1~5 part of hawthorn, 2~10 parts of Chinese yam, 2~10 parts of Poria cocos, 1~5 part of Radix Glycyrrhizae, 1~5 part of dried orange peel；It is described
The viable bacteria concentration of lactobacillus acidophilus is 0.5 × 1010~1.5 × 1010CFU/g.In the present invention, lactobacillus acidophilus improves dog intestines
Road Bacterial community, hawthorn, dried orange peel promote digestion, mitigate the irritability gastrointestinal reaction caused by metatrophia, Chinese yam, tuckahoe enhancing
Dog autoimmunity, and adjust gastrointestinal hormone level when stress reaction occurs in gastrointestinal tract and improve gastrointestinal tract to water and electrolysis
The ability of matter transport repairs mucosa injury.Radix Glycyrrhizae, coordinating the drug actions of a prescription enhance dog autoimmunity and play anti-inflammatory effect.The present invention
The additive of offer can be obviously improved the anti-stress ability of weaning stage puppy, adjust gastrointestinal function, and experiment shows：Experimental group with it is right
Compare according to group and be significantly improved on illness rate, appetite, coat gloss, activity, daily gain, intestinal flora composition, and with
Chinese yam, tuckahoe lacks taste group, and there were significant differences in illness rate, appetite, coat gloss, activity, daily gain.Illustrate Chinese yam, tuckahoe
Immunity may be being improved, improve gastrointestinal function in terms of balance stomach and intestine pH value, cooperate with probiotics, it is specific to act synergistically.
Specific embodiment
The present invention provides a kind of additives for having and adjusting pet functions of intestines and stomach, include the components of following parts by weight：It is thermophilic
2~10 parts of Lactobacillus lactis powder, 1~5 part of hawthorn, 2~10 parts of Chinese yam, 2~10 parts of Poria cocos, 1~5 part of Radix Glycyrrhizae, 1~5 part of dried orange peel；Institute
The viable bacteria concentration for stating lactobacillus acidophilus is 0.5 × 1010~1.5 × 1010CFU/g。
Additive provided by the invention includes lactobacillus acidophilus powder.By weight, the lactobacillus acidophilus powder is 2~10
Part, it is preferably 4~8 parts, more preferably 6 parts.The viable bacteria concentration of the lactobacillus acidophilus powder is 0.5 × 1010~1.5 ×
1010CFU/g is preferably 1 × 1010CFU/g.The lactobacillus acidophilus powder is conducive to adjust intestinal microflora, and stomach is promoted to disappear
Change.The present invention is not particularly limited the source of the lactobacillus acidophilus powder, using acidophilus well-known to those skilled in the art
Lactobacillus powder.In embodiments of the present invention, the lactobacillus acidophilus powder is purchased from the limited public affairs of hundred million bioengineering of Shandong Zhong Kejia
Department.
Additive provided by the invention includes hawthorn.By weight, the hawthorn is 1~5 part, is preferably 2~4 parts,
Most preferably 3 parts.The present invention is not particularly limited the source of the hawthorn, using well-known to those skilled in the art commercially available
Commodity.
Additive provided by the invention includes Chinese yam.By weight, the Chinese yam is 2~10 parts, is preferably 4~8 parts,
Most preferably 6 parts.The present invention is not particularly limited the source of the Chinese yam, using well-known to those skilled in the art commercially available
Commodity.
Additive provided by the invention includes Poria cocos.By weight, the Poria cocos is 2~10 parts, is preferably 4~8 parts,
Most preferably 6 parts.The present invention is not particularly limited the source of the Poria cocos, using well-known to those skilled in the art commercially available
Commodity.Additive provided by the invention includes Radix Glycyrrhizae.By weight, the Radix Glycyrrhizae is 1~5 part, is preferably 2~4 parts,
Most preferably 3 parts.The present invention is not particularly limited the source of the Radix Glycyrrhizae, using well-known to those skilled in the art commercially available
Commodity.
Additive provided by the invention includes dried orange peel.By weight, the dried orange peel is 1~5 part, is preferably 2~4 parts,
Most preferably 3 parts.The present invention is not particularly limited the source of the dried orange peel, using well-known to those skilled in the art commercially available
Commodity.
In the present invention, lactobacillus acidophilus improves dog intestinal microflora, and hawthorn, dried orange peel promote digestion, mitigate because of diet
Irritability gastrointestinal reaction caused by change, Chinese yam, tuckahoe enhancing dog autoimmunity, and the tune when stress reaction occurs in gastrointestinal tract
Save the ability that gastrointestinal hormone is horizontal and improvement gastrointestinal tract is to water and electrolyte transport, reparation mucosa injury.Radix Glycyrrhizae, coordinating the drug actions of a prescription,
Enhancing dog autoimmunity simultaneously plays anti-inflammatory effect.
In the present invention, the dosage form of the feed for pet additive is preferably granule.The granule preferably further includes 1
The auxiliary material of the auxiliary material of~3 parts by weight, more preferably 2 parts by weight.The auxiliary material preferably includes maltodextrin, dextrin, starch, sweet dew
It is one or more of in alcohol and lactose.It is preferably maltodextrin when the auxiliary material is a kind of.It is described auxiliary when the auxiliary material is two kinds
Material is preferably made of dextrin and lactose.The mass ratio of the dextrin and lactose is 1：1.When the auxiliary material is three kinds, the auxiliary material
It is preferred that it is made of dextrin, starch and mannitol.The mass ratio of the dextrin, starch and mannitol is 1：1：1.The auxiliary material is four
During kind, the auxiliary material is preferably made of dextrin, starch, mannitol and lactose.The dextrin, starch, the matter of mannitol and lactose
Amount is than being 1：1：1：1.
The present invention provides the preparation methods of the additive for having and adjusting pet functions of intestines and stomach, comprise the following steps：
1) hawthorn, Chinese yam, Poria cocos, Radix Glycyrrhizae and dried orange peel are crushed, sieves, obtain herb powder；
2) herb powder is sterilized, the herb powder to be sterilized；
3) herb powder of the sterilizing with lactobacillus acidophilus powder is mixed, obtains additive.
The present invention crushes hawthorn, Chinese yam, Poria cocos, Radix Glycyrrhizae and dried orange peel, and sieving obtains herb powder.
The method of the crushing and sieving is not particularly limited in the present invention, use is well-known to those skilled in the art
It crushes and screen method.It is mixed before the present invention crushes hawthorn, Chinese yam, Poria cocos, Radix Glycyrrhizae and dried orange peel after mixing or crushing
Conjunction is not particularly limited.
In the present invention, the aperture of the sieving is preferably 70~100 mesh, more preferably 80 mesh.
After obtaining herb powder, the present invention sterilizes the herb powder, the herb powder to be sterilized.
The present invention is not particularly limited the method for the sterilizing, using sterilizing methods well-known to those skilled in the art
.In embodiments of the present invention, the condition of the sterilizing is not particularly limited, and is using sterilizing scheme known in the art
It can.
After the herb powder to be sterilized, the present invention mixes the herb powder of the sterilizing with lactobacillus acidophilus powder, obtains
To additive.
The present invention is not particularly limited the mixed method, using mixed method known in the art.
In the present invention, when the dosage form of the additive is granule, the additive further includes auxiliary material, the particle
After the herb powder that the preparation method of agent is sterilized again, preferably by the herb powder of the sterilizing and auxiliary material mixing granulation, obtain
The Chinese medicinal granule arrived mixes again with lactobacillus acidophilus powder, obtains granule.
The present invention is not particularly limited the method for the granulation, using granulation scheme known in the art.
Additive prepared by the additive provided by the invention or the method is preparing prevention or treatment pet intestines
Application in tract disease drug.
In the present invention, the pet intestines problem is damaged including gastrointestinal mucosa.The feeding method of the additive is feeding
It feeds amount 4~10g/ times, one day 2~3 times, feeds 30 days.
Additive prepared by the additive provided by the invention or the method is preparing adjusting pet function of intestinal canal
Application in health products.
The pet includes pet cat, pet dog, pet lizard or pet tortoise.
In the present invention, the feeding method of the additive is that additive and diet are mixed to get mixed fodder, is used for
Feed pet；Or the additive is dissolved in 37 DEG C of drinking-water and is fed.The scale of feeding of the additive is 2~5g/ times, often
Day 2~3 times, feeding number of days are 30d.The mass ratio of the additive and diet is preferably 1：15~25.
With reference to embodiment to a kind of additive with adjusting pet functions of intestines and stomach provided by the invention and its preparation
Methods and applications are described in detail, but they cannot be interpreted as limiting the scope of the present invention.
Embodiment 1
Sample preparation：Hawthorn 100g, Chinese yam 200g, Poria cocos 200g, Radix Glycyrrhizae 100g, dried orange peel 100g crushed 80 mesh sieves, go out
Bacterium with 100g maltodextrin mixing granulations after mixing, then is uniformly mixed with the lactobacillus acidophilus powder of 200g, the lactobacillus acidophilus
The viable bacteria concentration of powder is 1 × 1010CFU/ml to get.
Embodiment 2
Sample preparation：Hawthorn 500g, Chinese yam 1000g, Poria cocos 1000g, Radix Glycyrrhizae 500g, dried orange peel 500g crushed 80 mesh sieves,
Sterilizing with 300g maltodextrin mixing granulations after mixing, then is uniformly mixed with the lactobacillus acidophilus powder of 1000g, the acidophilus breast
The viable bacteria concentration of bacillus powder is 0.6 × 1010CFU/ml to get.
Embodiment 3
Sample preparation：Hawthorn 200g, Chinese yam 800g, Poria cocos 400g, Radix Glycyrrhizae 400g, dried orange peel 200g crushed 70 mesh sieves, go out
Bacterium with 100g maltodextrin mixing granulations after mixing, then is uniformly mixed with the lactobacillus acidophilus powder of 400g, the lactobacillus acidophilus
The viable bacteria concentration of powder is 1.5 × 1010CFU/ml to get.
Embodiment 4
Sample preparation：Hawthorn 400g, Chinese yam 400g, Poria cocos 800g, Radix Glycyrrhizae 200g, dried orange peel 400g crushed 100 mesh sieves, go out
Bacterium with 200g maltodextrin mixing granulations after mixing, then is uniformly mixed with the lactobacillus acidophilus powder of 800g, the lactobacillus acidophilus
The viable bacteria concentration of powder is 1.2 × 1010CFU/ml to get.
Embodiment 5
Sample preparation：Hawthorn 300g, Chinese yam 600g, Poria cocos 600g, Radix Glycyrrhizae 300g, dried orange peel 300g crushed 90 mesh sieves, go out
Bacterium with 200g maltodextrin mixing granulations after mixing, then is uniformly mixed with the lactobacillus acidophilus powder of 600g, the lactobacillus acidophilus
The viable bacteria concentration of powder is 0.8 × 1010CFU/ml to get.
Comparative example 1
Chinese yam, tuckahoe lacks the preparation of taste group：Hawthorn 100g, Radix Glycyrrhizae 100g, dried orange peel 100g crushed 80 mesh sieves, sterilizing, after mixing
With 500g maltodextrin mixing granulations, then it is uniformly mixed with the lactobacillus acidophilus powder of 200g, the viable bacteria of the lactobacillus acidophilus powder
Concentration is 1 × 1010CFU/ml to get.
Embodiment 6
(1) experimental animal and grouping
Selection physically well develops, weaning stage capital puppy 56 is in similar in weight, is randomly divided into complete square experimental group 5
Group, Chinese yam, tuckahoe lack taste group and each one group of control group, every group 6, half male and half female.The common dog grain of control group fed, full side's experiment
Additive of the group feeding prepared by by regulation addition Examples 1 to 5, Chinese yam, tuckahoe lack addition prepared by taste group feeding comparative example 1
Agent.Feed period is 30d.
(2) feeding management
All raising in same animal house, takes identical feeding and management method, by special messenger raising pipe for experiment and control group
Reason.Then dog selects dog to mark into being cleaned before column, being sterilized to column home and crib.Expelling parasite is carried out before experiment, and is routinely exempted from
Epidemic disease vaccinates, after prerun, morning on an empty stomach by only weighing, each group average weight indifference (P ＞ 0.05) by inspection, as
Starting weight into formal experiment, raises 2 months phases.This experiment uses group feeding, daily feeding 4 times.Feed metering is quantity-unlimiting, gives
Food to have enough as principle, sweep animal house, rinse 1 time within every two days daily, per week to sterilize 1 time by the sufficient cleaning drinking-water of guarantee.It sees
The growth of dog is examined, develops, have loose bowels, appetite, the basic conditions such as feeding.
(3) Testing index and method
The average daily gain of A daily gains weekly the same time in early morning by puppy by only weighing on an empty stomach, by the difference of end weight and starting weight
Calculate the weightening of each puppy.
For B respectively in D0, D30 of experiment, per rectum takes dog excrement, is then placed in sterile chamber and is trained for intestinal flora
It supports and counts.The measure of microbe quantity in excrement:It is sterile to take excrement 0.5g, it is diluted to 10 with 0 times of ratio of two term of phosphate buffer 1-6, choosing
It selects suitable dilution factor and is inoculated in each selective medium respectively, each dilution factor sets 3 repetitions.Culture medium and condition of culture are such as
Following table.The colony characteristics that are formed according to bacterium on corresponding selective medium carry out it with reference to Gram's staining and microscopy
Identification.As a result represented with the logarithm (l CFU/g) of bacterium number in every gram of excrement.
1 culture medium of table and condition of culture：
| Relevant bacteria species | Culture medium and diluent media | Condition of culture |
| Lactobacillus | LBS | 37 DEG C, 48h, anaerobism |
| Bifidobacterium | BLB | 37 DEG C, 72h, anaerobism |
| Enterobacteria | EMB | It is 37 DEG C, for 24 hours, aerobic |
| Staphylococcus | SP | It is 37 DEG C, for 24 hours, aerobic |
| Enterococcus | Enterococcus agar | 37 DEG C, 48h is aerobic |
C data statistical analysis
Statistical analysis is carried out with 13.0 softwares of SPSS, data are represented with x ± s, significance test of difference variance point
Analysis as variance analysis has significant difference, then carries out Multiple range test.
(4) result
After A puppies are tested 30 days, full side's experimental group, Chinese yam, tuckahoe lack taste group and the scoring of control group puppy appearance is as follows
(10 points of full marks)：
2 puppy appearance of table scores
The changes of weight of 3 experimental dog of table
| Time | Control group | Full side's experimental group | Chinese yam, tuckahoe lacks taste group |
| Before experiment | 728.6±20.7 | 730.5±23.1 | 733.7±22.8 |
| After 30 days | 1245.2±304 | 1308.6±27.3* | 1249.2±31.1 |
| Daily gain | 17.2±1.7 | 19.2±2.2* | 17.2±2.8 |
Dog enteral bacterium is influenced
In D0, full side's experimental group and Chinese yam, tuckahoe lack taste group lactobacillus, Bifidobacterium, enterobacteria, staphylococcus and intestines ball
Bacterium is with control group without significant difference (P ＞ 0.05)；In D30, full side's experimental group and Chinese yam, tuckahoe lack taste group lactobacillus quantity and extremely show
It writes higher than control group (P ＜ 0.01), enterobacteria quantity pole is substantially less than control group (P ＜ 0.01), and bifidobacteria is significantly high
In control group (P ＜ 0.05), staphylococcus and enterococcus are substantially less than control group (P ＜ 0.05), are specifically shown in Table 4.
4 puppy enteral strain class of table and content
Conclusion：Additive provided by the invention can be obviously improved the anti-stress ability of weaning stage puppy, adjust gastrointestinal function,
It is equal on illness rate, appetite, coat gloss, activity, daily gain, intestinal flora composition compared with the control group to be embodied in experimental group
Be significantly improved, though and flora composition is adjusted without significant difference in the intestine compared with lacking taste group with Chinese yam, tuckahoe, in illness
Rate, appetite, coat gloss, activity, there were significant differences in daily gain.Illustrate that Chinese yam, tuckahoe may improve immunity, put down
Improve gastrointestinal function in terms of the stomach and intestine pH value that weighs, cooperate with probiotics, synergistic effect.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of have the additive for adjusting pet functions of intestines and stomach, which is characterized in that includes the component of following parts by weight：Acidophilus breast
2~10 parts of bacillus powder, 1~5 part of hawthorn, 2~10 parts of Chinese yam, 2~10 parts of Poria cocos, 1~5 part of Radix Glycyrrhizae, 1~5 part of dried orange peel；It is described thermophilic
The viable bacteria concentration of Lactobacillus lactis powder is 0.5 × 1010~1.5 × 1010CFU/g。
2. additive according to claim 1, which is characterized in that include the component of following parts by weight：Lactobacillus acidophilus powder 4
~8 parts, 2~4 parts of hawthorn, 4~8 parts of Chinese yam, 4~8 parts of Poria cocos, 2~4 parts of Radix Glycyrrhizae, 2~4 parts of dried orange peel.
3. additive according to claim 1 or 2, which is characterized in that include the component of following parts by weight：Lactobacillus acidophilus
6 parts of powder, 3 parts of hawthorn, 6 parts of Chinese yam, 6 parts of Poria cocos, 3 parts of Radix Glycyrrhizae, 3 parts of dried orange peel.
4. additive according to claim 3, which is characterized in that the viable bacteria concentration of the lactobacillus acidophilus powder for 1 ×
1010CFU/g。
5. additive according to claim 4, which is characterized in that the dosage form of the additive is granule；
The granule further includes the auxiliary material of 1~3 parts by weight；
The auxiliary material is one or more of in maltodextrin, dextrin, starch, mannitol and lactose.
6. having the preparation method for the additive for adjusting pet functions of intestines and stomach described in Claims 1 to 4 any one, feature exists
In comprising the following steps：
1) hawthorn, Chinese yam, Poria cocos, Radix Glycyrrhizae and dried orange peel are crushed, sieves, obtain herb powder；
2) herb powder is sterilized, the herb powder to be sterilized；
3) herb powder of the sterilizing with lactobacillus acidophilus powder is mixed, obtains additive.
7. preparation method according to claim 6, which is characterized in that described when the dosage form of the additive is granule
Additive further includes auxiliary material, and the step 3) is：By the herb powder of sterilizing and auxiliary material mixing granulation, obtained Chinese medicinal granule is again
It is mixed with lactobacillus acidophilus powder, obtains additive.
8. according to the preparation method of claim 6 or 7, which is characterized in that the aperture of sieving is 70~100 in the step 1)
Mesh.
9. additive prepared by the additive or claim 6~8 any one the method described in Claims 1 to 5 is being made
It is standby to prevent or treat the application in pet intestines problem drug.
10. additive prepared by the additive or claim 6~8 any one the method described in Claims 1 to 5 is being made
Application in the standby health products for adjusting pet function of intestinal canal.
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| CN109170303A (en) * | 2018-11-13 | 2019-01-11 | 珠海亚和生物科技有限公司 | A kind of additive adjusting pet functions of intestines and stomach |
| CN109527244A (en) * | 2018-12-26 | 2019-03-29 | 广东省农业科学院动物卫生研究所 | A kind of feed addictive and its application |
| CN111296637A (en) * | 2020-03-19 | 2020-06-19 | 潍坊富邦药业有限公司 | Traditional Chinese medicine extract feed additive for pet and capable of tonifying spleen, invigorating stomach and promoting growth and preparation method of traditional Chinese medicine extract feed additive |
| CN111567696A (en) * | 2020-05-09 | 2020-08-25 | 上海耐威克宠物用品有限公司 | Functional beverage for pets and preparation method thereof |
| CN111838446A (en) * | 2020-08-14 | 2020-10-30 | 山东美斯宠物食品股份有限公司 | Pet complete food added with tetragenous fungi |
| CN112155130A (en) * | 2020-09-16 | 2021-01-01 | 上海耐威克宠物用品有限公司 | Functional seasoning product for pet food and preparation method thereof |
| CN112273533A (en) * | 2020-10-28 | 2021-01-29 | 广州福懋畜牧兽医服务有限公司 | Dog food for intestinal tract care and preparation method thereof |
| CN114886019A (en) * | 2022-05-24 | 2022-08-12 | 四川恒通动物制药有限公司 | Animal feed additive with intestine and stomach health care function and preparation method thereof |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109170303A (en) * | 2018-11-13 | 2019-01-11 | 珠海亚和生物科技有限公司 | A kind of additive adjusting pet functions of intestines and stomach |
| CN109527244A (en) * | 2018-12-26 | 2019-03-29 | 广东省农业科学院动物卫生研究所 | A kind of feed addictive and its application |
| CN111296637A (en) * | 2020-03-19 | 2020-06-19 | 潍坊富邦药业有限公司 | Traditional Chinese medicine extract feed additive for pet and capable of tonifying spleen, invigorating stomach and promoting growth and preparation method of traditional Chinese medicine extract feed additive |
| CN111567696A (en) * | 2020-05-09 | 2020-08-25 | 上海耐威克宠物用品有限公司 | Functional beverage for pets and preparation method thereof |
| CN111838446A (en) * | 2020-08-14 | 2020-10-30 | 山东美斯宠物食品股份有限公司 | Pet complete food added with tetragenous fungi |
| CN112155130A (en) * | 2020-09-16 | 2021-01-01 | 上海耐威克宠物用品有限公司 | Functional seasoning product for pet food and preparation method thereof |
| CN112273533A (en) * | 2020-10-28 | 2021-01-29 | 广州福懋畜牧兽医服务有限公司 | Dog food for intestinal tract care and preparation method thereof |
| CN114886019A (en) * | 2022-05-24 | 2022-08-12 | 四川恒通动物制药有限公司 | Animal feed additive with intestine and stomach health care function and preparation method thereof |
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