CN108042787A - A kind of Soboring-up liver-protecting composition, preparation and preparation method thereof - Google Patents
A kind of Soboring-up liver-protecting composition, preparation and preparation method thereof Download PDFInfo
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- CN108042787A CN108042787A CN201810008185.9A CN201810008185A CN108042787A CN 108042787 A CN108042787 A CN 108042787A CN 201810008185 A CN201810008185 A CN 201810008185A CN 108042787 A CN108042787 A CN 108042787A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/011—Hydrolysed proteins; Derivatives thereof from plants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Abstract
The invention discloses a kind of Soboring-up liver-protecting composition, by weight including following components：450 550 parts of corn oligopeptide powder, 450 550 parts of kudzu-vine root powder, 250 350 parts of hoveniae semoveniae semen powder, 150 250 parts of gardenia powder, said composition play an important role of that protect liver, time of sobering up are short.The invention also discloses a kind of Soboring-up liver-protecting preparation, and preparation method thereof.This method is easy to operate, and Soboring-up liver-protecting preparation is convenient for carrying, be easy to according to itself need take at any time.
Description
Technical field
The invention belongs to health product technology fields more particularly to a kind of Soboring-up liver-protecting composition, preparation and preparation method thereof.
Background technology
Liver is the nutrition of body body absorption, the organ for removing the metabolic functions such as toxin, is that blood is basic, therefore liver
Quality directly affects health, and the diet of the non-rule of people work and rest custom directly affects the load of liver, especially
For the personage that drinks, long-term excessive drinking causes the damage of liver, easily causes alcoholic liver disease, based on this reason, occur in the market
The product of liver-protecting sober-up class.
Liver-protecting sober-up class product includes drug, health food and food at present.Wherein, the secondary work of drug liver-protecting sober-up product
With bigger, if it is permanent it is edible will easily trigger other negative diseases, although the liver-protecting sober-up product of health food and food
With certain liver protection effect, but the quality level of liver-protection health-care product in the market is uneven, functional store list one or
Only liver protection effect or only sobering-up functions, it is ineffective even if having protect liver and anti-alcohol function, and Time of Administration is limited,
It cannot take at any time.
The content of the invention
In view of the problems of the above-mentioned prior art, the purpose of the present invention is to propose to a kind of Soboring-up liver-protecting composition, the groups
Conjunction object plays an important role of protect liver and the time of sobering up is short.
The mixture for a variety of small peptides that maize oligopeptide is explained by enzyme as zein and obtained.Maize oligopeptide energy
The activity of the aspartate aminotransferase of hepatic injury mouse and alanine aminotransferase caused by significantly reducing carbon tetrachloride promotees
Into liver function recovery.Maize oligopeptide can shorten the drunk time of mouse, reduce ethanol in blood and the content of acetaldehyde.
Kudzu-vine root powder：Pueraria lobata is the root of pulse family platymiscium elegant jessamine, has relieving muscles diaphoresis, invigorating vital function and promoting eruption, antipyretic the effect of promoting the production of body fluid.
Modern biology research has shown that Chinese medicament kudzu-vine root Aqueous extracts have preventive and therapeutic effect to rat chronic alcoholic liver injury.Kudzu root extract
To the activity of alcoholic liver injury in rats serum aspartat aminopherase and alanine aminotransferase, malonaldehyde is reduced
Content improves the activity of superoxide dismutase.Pueraria lobata can effectively avoid or mitigate acute liver damage caused by alcohol.
Hoveniae semoveniae semen is the dry mature seed of Rhamnaceae honey raisin tree platymiscium hoveniae semoveniae semen, has cough-relieving relieving restlessness, relieving alcoholism, town
It is quiet, the effect of diuresis.Raisin tree seed extract plays an important role of anti peroxidation of lipid, protection hepatocyte activity.Studies have found that trifoliate orange
Dulcis seed extracts can block the occurrence and development of liver fibrosis, protect hepatocyte activity, your liver cell reparative regeneration.
Cape jasmine is the dry mature fruit of Rubiaceae cape jasmine, is produced in the provinces such as Sichuan, Hubei, Jiangxi, Chongqing, has purging intense heat
The effect of relieving restlessness, clearing away heat,cooling blood and removing toxin, suitable for jaundice, red eye, swell pain.It is notable that modern pharmacological research proves that cape jasmine has
Protecting liver, lowering enzymes, normalizing gallbladder to cure jaundice, antipyretic and anti-inflammatory pharmacological action.The Decotion of Capejasmine and Phellodendron there is protection to rent acute liver
With to rat with choleretic effect.
The purpose of the present invention will be achieved by the following technical programs：
A kind of Soboring-up liver-protecting composition, by weight including following components：450-550 parts of corn oligopeptide powder, pueraria lobata
450-550 parts of powder, 250-350 parts of hoveniae semoveniae semen powder, 150-250 parts of gardenia powder.
Above-mentioned Soboring-up liver-protecting composition, wherein, by weight including following components：Corn oligopeptide powder 480-530
Part, 460-530 parts of kudzu-vine root powder, 280-320 parts of hoveniae semoveniae semen powder, 180-230 parts of gardenia powder.
Another object of the present invention is to propose a kind of Soboring-up liver-protecting preparation, and said preparation is tablet, is convenient for carrying, Ke Yisui
When take according to demand.
A kind of Soboring-up liver-protecting preparation, wherein, it is formed including above-mentioned Soboring-up liver-protecting composition and auxiliary material.
A kind of above-mentioned Soboring-up liver-protecting preparation, wherein, the ratio of weight and number of the Soboring-up liver-protecting composition and the auxiliary material
For 1300-1700: 465-575.
A kind of above-mentioned Soboring-up liver-protecting preparation, wherein, by weight, the auxiliary material is by 450-550 parts of corrigent, tristearin
Sour magnesium 15-25 parts of compositions.
A kind of above-mentioned Soboring-up liver-protecting preparation, wherein, the corrigent is selected from lactose or maltodextrin.
Third object of the present invention is to provide a kind of preparation method of Soboring-up liver-protecting preparation, and this method is easy to operate, and
Its active constituent content has reached 500mg/ pieces.
A kind of preparation method of Soboring-up liver-protecting preparation, includes the following steps：1) corn oligopeptide powder, kudzu-vine root powder, trifoliate orange Dulcis are taken
Sub- powder, gardenia powder, corrigent crush, sieving, weigh by weight, mix, and sieving obtains mixed powder；
2) 95% ethanol solution is added in mixed powder and softwood is made；
3) softwood is sieved and pelletized, obtain wet granular；
4) by wet granular drying to moisture≤5%, whole grain of sieving obtains dry particl；
5) stiffened fatty acid magnesium is in dry particl, mixes 4-20min, tabletting to get.
Above-mentioned preparation method, wherein, the grit number of crossing in the step 3) and step 4) is 18 mesh.
Above-mentioned preparation method, wherein, the content of Soboring-up liver-protecting preparation is 500mg/ pieces.
Compared with prior art, a kind of Soboring-up liver-protecting composition provided by the invention, preparation and preparation method thereof, reach
It has the technical effect that：The functional nutrient substance maize oligopeptide and integration of drinking and medicinal herbs that the present invention is produced using modern biotechnology
Kudzu-vine root powder, hoveniae semoveniae semen powder, gardenia powder as functional materials science component, synergistic, the tablet of preparation is without side-effects, side
Portable belt；Preparation method is simple, is easy to industrialized production；The tablet that simultaneously prepared by the present invention, not only can be in forward and backward food of drinking
With, and can be eaten for a long time, auxiliary conditioning liver, protection liver；
Product of the present invention plays an important role of to protect liver and shortens the drunk time.A couple of days is taken before drinking can improve liver
The activity of dirty cell reduces the damage of liver cell during drinking.According to more than data, the product is eaten after drinking can be with
Shorten the drunk time, reduce ethanol in blood and the content of acetaldehyde.
Below just in conjunction with the embodiments, the embodiment of the present invention is described in further detail, so that technical solution is more
It should be readily appreciated that, grasp.
Specific embodiment
Below by specific embodiment, the present invention will be described, but the present invention is not limited thereto.In following embodiments
The experimental method is conventional method unless otherwise specified；The reagent and material, unless otherwise specified, can be from business
Approach obtains, and example below is not to limit the scope of the claims of the present invention, all equivalence enforcements without departing from carried out by the present invention
Or change, it is intended to be limited solely by the scope of this patent.
Embodiment 1
Soboring-up liver-protecting preparation provided in this embodiment, is made of the component of following parts by weight：Corn oligopeptide powder (80%
Protein) 500 parts, 500 parts of kudzu-vine root powder (15% puerarin content), 300 parts of hoveniae semoveniae semen powder, 200 parts of gardenia powder, 500 parts of lactose；
20 parts of magnesium stearate.
Embodiment 2
Soboring-up liver-protecting preparation provided in this embodiment, is made of the component of following parts by weight：Corn oligopeptide powder (80%
Protein) 450 parts, 450 parts of kudzu-vine root powder (15% puerarin content), 250 parts of hoveniae semoveniae semen powder, 150 parts of gardenia powder, 450 parts of lactose；
15 parts of magnesium stearate.
Embodiment 3
Soboring-up liver-protecting preparation provided in this embodiment, is made of the component of following parts by weight：Corn oligopeptide powder 5 (80%
Protein) 10 parts, 520 parts of kudzu-vine root powder (15% puerarin content), 310 parts of hoveniae semoveniae semen powder, 230 parts of gardenia powder, lactose 520
Part；22 parts of magnesium stearate.
Embodiment 4
Soboring-up liver-protecting preparation provided in this embodiment, is made of the component of following parts by weight：Corn oligopeptide powder (80%
Protein) 480 parts, 480 parts of kudzu-vine root powder (15% puerarin content), 280 parts of hoveniae semoveniae semen powder, 180 parts of gardenia powder, 490 parts of lactose；
18 parts of magnesium stearate.
Embodiment 5
Soboring-up liver-protecting preparation provided in this embodiment, is made of the component of following parts by weight：Corn oligopeptide powder (80%
Protein) 550 parts, 530 parts of kudzu-vine root powder (15% puerarin content), 350 parts of hoveniae semoveniae semen powder, 250 parts of gardenia powder, 550 parts of lactose；
25 parts of magnesium stearate.
Embodiment 6
Soboring-up liver-protecting preparation provided in this embodiment, is made of the component of following parts by weight：Corn oligopeptide powder (80%
Protein) 530 parts, 550 parts of kudzu-vine root powder (15% puerarin content), 320 parts of hoveniae semoveniae semen powder, 230 parts of gardenia powder, maltodextrin
530 parts；23 parts of magnesium stearate.
The preparation method of embodiment 1-5 Soboring-up liver-protecting preparations：Take corn oligopeptide powder, kudzu-vine root powder, hoveniae semoveniae semen powder, cape jasmine
Powder, lactose crush, sieve, mixed by weight, sieve, and magnesium stearate weighs, spare；95% ethanol solution is added in
Softwood is made into mixed powder；Softwood is selected into the granulation of 18 mesh sieves, obtains wet granular；It will be dry at 45 DEG C~75 DEG C of wet granular
To moisture≤5%, then 18 mesh sieve whole grains are selected, obtain dry particl；Stiffened fatty acid magnesium mixes 5min with dry particl, obtains and always mixes
Object, by total mixture tabletting obtain 500mg/ pieces to get.
Difference lies in replace with malt paste to the preparation method of 6 Soboring-up liver-protecting preparation of embodiment by lactose with embodiment 1-5
Essence.
The formula of 1 comparative example 1-6 Soboring-up liver-protecting preparations of table
| Corn oligopeptide powder | Kudzu-vine root powder | Hoveniae semoveniae semen powder | Gardenia powder | Lactose | Magnesium stearate | |
| Comparative example 1 | 500 | 500 | 20 | |||
| Comparative example 2 | 500 | 500 | 20 | |||
| Comparative example 3 | 300 | 500 | 20 | |||
| Comparative example 4 | 200 | 500 | 20 | |||
| Comparative example 5 | 500 | 300 | 200 | 500 | 20 | |
| Comparative example 6 | 500 | 500 | 500 | 20 |
Effect test：
Embodiment 1-6 will be prepared into according to standard food working condition and aforementioned production method, comparative example 1-6 sobers up
Liver-care preparations carry out effect experiment.
Experiment number：96
Experimental standard：The malaise symptoms such as nausea and vomiting, dizzy weak, instability of gait, incoherent are shown, but are realized
Clearly.
Laboratory sample：Embodiment 1-6, comparative example 1-6.
Eating method：Everyone is 6 edible, is swallowed with water.
12 groups are divided at random, eats the relieving alcoholism and protecting liver product that embodiment 1-6 and comparative example 1-6 is prepared respectively.It is edible
Method is：With 6 relieving alcoholism and protecting liver pieces prepared are taken after drinking, 100-200 milliliters of plain boiled water are then drunk.60 points of observation
The quantity for the people that symptom improves in clock.
The effect test of 2 Soboring-up liver-protecting composition of table
| Group | Symptom changes number | Group | Symptom changes number |
| Comparative example 1 | 5 | Embodiment 1 | 5 |
| Comparative example 2 | 2 | Embodiment 2 | 6 |
| Comparative example 3 | 3 | Embodiment 3 | 5 |
| Comparative example 4 | 2 | Embodiment 4 | 5 |
| Comparative example 5 | 5 | Embodiment 5 | 4 |
| Comparative example 6 | 4 | Embodiment 6 | 5 |
Several preferred embodiments of the present invention have shown and described in above description, but as previously described, it should be understood that the present invention
Be not limited to form disclosed herein, be not to be taken as the exclusion to other embodiment, and available for various other combinations,
Modification and environment, and above-mentioned introduction or the technology or knowledge of association area can be passed through in the scope of the invention is set forth herein
It is modified.And changes and modifications made by those skilled in the art do not depart from the spirit and scope of the present invention, then it all should be in this hair
In the protection domain of bright appended claims.
Claims (9)
1. a kind of Soboring-up liver-protecting composition, which is characterized in that by weight including following components：Corn oligopeptide powder 450-
550 parts, 450-550 parts of kudzu-vine root powder, 250-350 parts of hoveniae semoveniae semen powder, 150-250 parts of gardenia powder.
2. Soboring-up liver-protecting composition according to claim 1, which is characterized in that by weight including following components：It is beautiful
Oligomeric Gly-His-Lys 480-530 parts of rice, 460-530 parts of kudzu-vine root powder, 280-320 parts of hoveniae semoveniae semen powder, 180-230 parts of gardenia powder.
3. a kind of Soboring-up liver-protecting preparation, which is characterized in that including any one of claim 1-2 Soboring-up liver-protecting compositions and auxiliary
Material composition.
A kind of 4. Soboring-up liver-protecting preparation according to claim 3, which is characterized in that the Soboring-up liver-protecting composition and described
The ratio of weight and number of auxiliary material is 1300-1700: 465-575.
5. a kind of Soboring-up liver-protecting preparation according to claim 3, which is characterized in that by weight, the auxiliary material is by dilute
Release 15-25 parts of 450-550 parts of agent, magnesium stearate compositions.
6. a kind of Soboring-up liver-protecting preparation according to claim 5, which is characterized in that the diluent is selected from lactose or malt
Dextrin.
7. according to the preparation method of claim 3-6 any one of them Soboring-up liver-protecting preparations, which is characterized in that including walking as follows
Suddenly：1) corn oligopeptide powder, kudzu-vine root powder, hoveniae semoveniae semen powder, gardenia powder, corrigent is taken to crush, sieving, weighs, mix by weight,
Sieving, obtains mixed powder；
2) 95% ethanol solution is added in mixed powder and softwood is made；
3) softwood is sieved and pelletized, obtain wet granular；
4) by wet granular drying to moisture≤5%, whole grain of sieving obtains dry particl；
5) stiffened fatty acid magnesium is in dry particl, mixes 4-6min, tabletting to get.
8. preparation method according to claim 7, which is characterized in that the grit number excessively in the step 3) and step 4) is equal
For 18 mesh.
9. preparation method according to claim 7, which is characterized in that the content of Soboring-up liver-protecting preparation is 500mg/ pieces.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109007808A (en) * | 2018-08-14 | 2018-12-18 | 宝健（北京）生物技术有限公司 | A kind of relieving alcoholism and protecting liver composition and the relieving alcoholism and protecting liver preparation comprising it |
| CN110169480A (en) * | 2019-04-24 | 2019-08-27 | 广东润源中天生物科技有限公司 | A kind of corn peptide pueraria lobata hoveniae semoveniae semen pressed candy and preparation method thereof |
| CN110419743A (en) * | 2019-08-21 | 2019-11-08 | 中新国际联合研究院 | A kind of oxidation resistant pulvis of natural liver protection and preparation method thereof |
| CN114052251A (en) * | 2021-12-23 | 2022-02-18 | 光明乳业股份有限公司 | Liver-protecting and alcohol-dispelling assisting tablet and preparation method thereof |
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| CN1931270A (en) * | 2006-09-15 | 2007-03-21 | 福州大学 | Sobering up and liver protecting Chinese medicine prepn and its prepn process |
| CN104323231A (en) * | 2014-11-27 | 2015-02-04 | 广州合诚实业有限公司 | Liver-protecting sobering-up natural composition, liver-protecting sobering-up natural product and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109007808A (en) * | 2018-08-14 | 2018-12-18 | 宝健（北京）生物技术有限公司 | A kind of relieving alcoholism and protecting liver composition and the relieving alcoholism and protecting liver preparation comprising it |
| CN110169480A (en) * | 2019-04-24 | 2019-08-27 | 广东润源中天生物科技有限公司 | A kind of corn peptide pueraria lobata hoveniae semoveniae semen pressed candy and preparation method thereof |
| CN110419743A (en) * | 2019-08-21 | 2019-11-08 | 中新国际联合研究院 | A kind of oxidation resistant pulvis of natural liver protection and preparation method thereof |
| CN114052251A (en) * | 2021-12-23 | 2022-02-18 | 光明乳业股份有限公司 | Liver-protecting and alcohol-dispelling assisting tablet and preparation method thereof |
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