CN108186732A - A kind of production method of ox toad particle - Google Patents
A kind of production method of ox toad particle Download PDFInfo
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- CN108186732A CN108186732A CN201810212111.7A CN201810212111A CN108186732A CN 108186732 A CN108186732 A CN 108186732A CN 201810212111 A CN201810212111 A CN 201810212111A CN 108186732 A CN108186732 A CN 108186732A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/413—Gall bladder; Bile
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/65—Amphibians, e.g. toads, frogs, salamanders or newts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a kind of production methods of ox toad particle; it first passes through the method for calculus bovis factitius, the dried venom of toads milled processed in absolute ethyl alcohol; active constituent in calculus bovis factitius, the dried venom of toads is extracted in alcohol solvent; then using stearic acid as embedding lipid; using polyoxyethylene sorbitan monoleate as surfactant; it is emulsified by high temperature, the solid lipid nano granule for being embedded with calculus bovis factitius, dried venom of toads active constituent is made in the even method being combined of high pressure breast; then with radix scutellariae, the water extract preparation mixing granulation of Radix Glycyrrhizae; borneol liquid is uniformly sprayed into, obtains ox toad particle.Dispersion effect is good in water for ox toad particle produced by the invention, easy to use, good absorption effect, is conducive to improve curative effect of medication.
Description
Technical field
The present invention relates to technical field of veterinary more particularly to a kind of production methods of ox toad particle.
Background technology
The ingredient of ox toad particle includes calculus bovis factitius, the dried venom of toads, borneol, radix scutellariae and Radix Glycyrrhizae, and effect is clearing heat and detoxicating, disease-resistant
Poison, it is relieving cough and asthma, severe breathing problem can be prevented and exhaled with viral disease mixed infection, virus mycoplasma disease, protracted course of disease
Road disease etc. is inhaled, is mainly used for livestock and poultry viral disease and breathing problem.Wherein, calculus bovis factitius deoxygenates courage by bilein, cholic acid, pig
Acid, taurine, bilirubin, cholesterol, trace element etc. are processed into, and have the effect of clearing heat and detoxicating, resolving sputum is calmed the frightened.The dried venom of toads is toad
The secretion of bufonid toad ear rear gland and epidermal gland can detoxify, detumescence, cardiac stimulant, analgesic, and main active therein is glucoside member,
For steroid.
At present, it uses for convenience, ox toad particle is made predominantly into Chinese medicinal granule electuary, can drink water, can spice.But
It is disadvantageous in that, the dissolubility of the dried venom of toads and calculus bovis factitius in water is poor, and valuable pharmacological active constituent is not soluble in water, causes
Dispersion effect is poor in water for ox toad particle, not only for drinking-water use put to no little inconvenience, and be unfavorable for it is right after animal takes
The absorption of active constituents of medicine, so as to affect the treatment.
Invention content
The defects of the object of the invention is exactly to make up prior art, providing one kind, dispersion effect is good in water, user
Just, the production method of the ox toad particle of good absorption effect.
The present invention is achieved by the following technical solutions：
A kind of production method of ox toad particle, includes the following steps：
（1）Weigh 4-5 parts by weight calculus bovis factitius, the 2-3 parts by weight dried venom of toads, 2-3 parts by weight borneol, 1000-1200 parts by weight radix scutellariae,
200-300 parts by weight Radix Glycyrrhizaes are spare；
（2）By step（1）Calculus bovis factitius, the dried venom of toads weighed, which is added in 100-150 parts by weight absolute ethyl alcohols, to be ground uniformly, then mistake
Filter, 10-15 parts by weight stearic acid is added in into obtained filtrate, and heating stirring 0.5-1h makes its fully dispersed；
（3）5-15 parts by weight Tween-80s are dissolved in 400-500 parts by weight water, are slowly added to walk in a heated condition
Suddenly（2）Obtained material and high-speed stirred 10-15min, is first removed under reduced pressure ethyl alcohol, then the even 4-5min of high pressure breast, spray drying
Powder is made；
（4）By step（1）The borneol weighed, which is added in appropriate absolute ethyl alcohol, to be dissolved completely, obtains borneol liquid；
（5）By step（1）The radix scutellariae that weighs, Radix Glycyrrhizae add water to cook 3-4 times respectively, decocting liquid is merged, concentrate after be spray dried to
Powder, with step（3）Then obtained material mixing adds in suitable quantity of water and auxiliary material granulation, step is uniformly sprayed into after low temperature drying
（4）Obtained borneol liquid places 24-48h to get ox toad particle in closed container.
The step（2）The middle sieve used that filters is 80-100 mesh.
The step（2）In condition of heating and stirring be 60-70 DEG C.
The step（3）In heating condition be 70-75 DEG C.
The step（3）In high-speed stirred condition be 1000-1500r/min.
The step（3）In the even condition of high pressure breast be 80-100MPa.
The auxiliary material is sucrose, dextrin or its mixture.
It is an advantage of the invention that：
The present invention is first passed through the method for calculus bovis factitius, the dried venom of toads milled processed in absolute ethyl alcohol, will be in calculus bovis factitius, the dried venom of toads
Active constituent is extracted in alcohol solvent, then using stearic acid as embedding lipid, using Tween-80 as surfactant, is led to
Cross high temperature emulsification, the solid lipid nano for being embedded with calculus bovis factitius, dried venom of toads active constituent is made in the even method being combined of high pressure breast
Grain then with radix scutellariae, the water extract preparation mixing granulation of Radix Glycyrrhizae, uniformly sprays into borneol liquid, obtains ox toad particle.Wherein, pass through
Active constituent in calculus bovis factitius, the dried venom of toads is fully encapsulated in the solid lipid nano granule that can be uniformly dispersed in water, a side
The stability of active constituent in water is improved in face, improves the dispersion effect of drug granule in water, on the other hand utilizes nanoparticle
To the adherency compatibility of gastrointestinal tract, intake and utilization of the animal to active constituent are improved, the ox toad particle of production is made to divide in water
It is good to dissipate effect, easy to use, good absorption effect is conducive to improve curative effect of medication.
Specific embodiment
A kind of production method of ox toad particle, includes the following steps：
（1）It is spare to weigh 4g calculus bovis factitiuses, the 2g dried venoms of toads, 2g borneols, 1000g radix scutellariaes, 200g Radix Glycyrrhizaes；
（2）By step（1）The calculus bovis factitius that weighs, the dried venom of toads, which are added in 100g absolute ethyl alcohols, to be ground uniform, is then filtered, to obtaining
Filtrate in add in 10g stearic acid, heating stirring 0.5h makes its fully dispersed；
（3）5g Tween-80s are dissolved in 400g water, are slowly added to step in a heated condition（2）Obtained material is simultaneously
Ethyl alcohol is first removed under reduced pressure in high-speed stirred 10min, and powder is made in the then even 4min of high pressure breast, spray drying；
（4）By step（1）The borneol weighed, which is added in 10g absolute ethyl alcohols, to be dissolved completely, obtains borneol liquid；
（5）By step（1）The radix scutellariae that weighs, Radix Glycyrrhizae add water to cook 3 times respectively, decocting liquid is merged, concentrate after spraying drying powder-forming
End, with step（3）Then obtained material mixing adds in 20-30g water and the granulation of 150-250g dextrin, after low temperature drying uniformly
Spray into step（4）Obtained borneol liquid is placed for 24 hours in closed container to get ox toad particle.
The step（2）The middle sieve used that filters is 80 mesh.
The step（2）In condition of heating and stirring be 60 DEG C.
The step（3）In heating condition be 70 DEG C.
The step（3）In high-speed stirred condition be 1000r/min.
The step（3）In the even condition of high pressure breast be 80MPa.
Claims (7)
1. a kind of production method of ox toad particle, which is characterized in that include the following steps：
（1）Weigh 4-5 parts by weight calculus bovis factitius, the 2-3 parts by weight dried venom of toads, 2-3 parts by weight borneol, 1000-1200 parts by weight radix scutellariae,
200-300 parts by weight Radix Glycyrrhizaes are spare；
（2）By step（1）Calculus bovis factitius, the dried venom of toads weighed, which is added in 100-150 parts by weight absolute ethyl alcohols, to be ground uniformly, then mistake
Filter, 10-15 parts by weight stearic acid is added in into obtained filtrate, and heating stirring 0.5-1h makes its fully dispersed；
（3）5-15 parts by weight Tween-80s are dissolved in 400-500 parts by weight water, are slowly added to walk in a heated condition
Suddenly（2）Obtained material and high-speed stirred 10-15min, is first removed under reduced pressure ethyl alcohol, then the even 4-5min of high pressure breast, spray drying
Powder is made；
（4）By step（1）The borneol weighed, which is added in appropriate absolute ethyl alcohol, to be dissolved completely, obtains borneol liquid；
（5）By step（1）The radix scutellariae that weighs, Radix Glycyrrhizae add water to cook 3-4 times respectively, decocting liquid is merged, concentrate after be spray dried to
Powder, with step（3）Then obtained material mixing adds in suitable quantity of water and auxiliary material granulation, step is uniformly sprayed into after low temperature drying
（4）Obtained borneol liquid places 24-48h to get ox toad particle in closed container.
A kind of 2. production method of ox toad particle according to claim 1, which is characterized in that the step（2）Middle filtering
The sieve used is 80-100 mesh.
A kind of 3. production method of ox toad particle according to claim 1, which is characterized in that the step（2）In plus
Thermal agitation condition is 60-70 DEG C.
A kind of 4. production method of ox toad particle according to claim 1, which is characterized in that the step（3）In plus
Heat condition is 70-75 DEG C.
A kind of 5. production method of ox toad particle according to claim 1, which is characterized in that the step（3）In height
Fast stirring condition is 1000-1500r/min.
A kind of 6. production method of ox toad particle according to claim 1, which is characterized in that the step（3）In height
The even condition of pressure breast is 80-100MPa.
7. the production method of a kind of ox toad particle according to claim 1, which is characterized in that the auxiliary material is sucrose, paste
Essence or its mixture.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810212111.7A CN108186732A (en) | 2018-03-15 | 2018-03-15 | A kind of production method of ox toad particle |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810212111.7A CN108186732A (en) | 2018-03-15 | 2018-03-15 | A kind of production method of ox toad particle |
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| Publication Number | Publication Date |
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| CN108186732A true CN108186732A (en) | 2018-06-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810212111.7A Pending CN108186732A (en) | 2018-03-15 | 2018-03-15 | A kind of production method of ox toad particle |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109248178A (en) * | 2018-10-19 | 2019-01-22 | 江苏浦金药业有限公司 | A kind of filter method in Venenum Bufonis Injection preparation process |
| CN110384727A (en) * | 2019-07-22 | 2019-10-29 | 江西旭虹药业有限公司 | A kind of ox toad particle and its preparation method and application |
| CN113057979A (en) * | 2019-12-31 | 2021-07-02 | 洛阳惠德生物工程有限公司 | Method for producing and preparing Bufo bufo gargarizans granule, prepared Bufo bufo gargarizans granule and application |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1951401A (en) * | 2005-10-19 | 2007-04-25 | 上海医药工业研究院 | Solid liposome nanoparticles of arenobufagin and preparation method thereof |
| CN101579404A (en) * | 2009-06-23 | 2009-11-18 | 天津必佳药业集团有限公司 | Traditional Chinese medicine granules for treating infectious laryngotracheitis of chicken, and preparation method thereof |
-
2018
- 2018-03-15 CN CN201810212111.7A patent/CN108186732A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1951401A (en) * | 2005-10-19 | 2007-04-25 | 上海医药工业研究院 | Solid liposome nanoparticles of arenobufagin and preparation method thereof |
| CN101579404A (en) * | 2009-06-23 | 2009-11-18 | 天津必佳药业集团有限公司 | Traditional Chinese medicine granules for treating infectious laryngotracheitis of chicken, and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 中国兽药典委员会: "《兽药质量标准：2017年版 中药卷》", 31 October 2017, 中国农业出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109248178A (en) * | 2018-10-19 | 2019-01-22 | 江苏浦金药业有限公司 | A kind of filter method in Venenum Bufonis Injection preparation process |
| CN110384727A (en) * | 2019-07-22 | 2019-10-29 | 江西旭虹药业有限公司 | A kind of ox toad particle and its preparation method and application |
| CN113057979A (en) * | 2019-12-31 | 2021-07-02 | 洛阳惠德生物工程有限公司 | Method for producing and preparing Bufo bufo gargarizans granule, prepared Bufo bufo gargarizans granule and application |
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Application publication date: 20180622 |