CN108026515B - 用于预防和/或治疗感染性疾病以及用于治疗肿瘤疾病的减毒流感病毒载体 - Google Patents

用于预防和/或治疗感染性疾病以及用于治疗肿瘤疾病的减毒流感病毒载体 Download PDF

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CN108026515B
CN108026515B CN201680033797.2A CN201680033797A CN108026515B CN 108026515 B CN108026515 B CN 108026515B CN 201680033797 A CN201680033797 A CN 201680033797A CN 108026515 B CN108026515 B CN 108026515B
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virus
influenza
protein
influenza virus
attenuated
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CN108026515A (zh
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安德烈·尤里耶维奇·叶戈罗夫
博里斯·费尔科
阿尔乔姆·亚历山德罗维奇·克罗欣
尤利安·罗曼诺芙娜·罗曼诺娃
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Vladimir Yevgeniyevich Neborisin
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Biotechnology Pharmaceutical Co ltd
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CN201680033797.2A 2015-11-06 2016-11-03 用于预防和/或治疗感染性疾病以及用于治疗肿瘤疾病的减毒流感病毒载体 Active CN108026515B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
RU2015147703 2015-11-06
RU2015147703A RU2628690C2 (ru) 2015-11-06 2015-11-06 Аттенуированные гриппозные векторы для профилактики и/или лечения инфекционных заболеваний, а также для лечения онкологических заболеваний
PCT/RU2016/050066 WO2017078577A2 (ru) 2015-11-06 2016-11-03 Аттенуированные гриппозные векторы для профилактики и/или лечения инфекционных заболеваний, а также для лечения онкологических заболеваний

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CN108026515A CN108026515A (zh) 2018-05-11
CN108026515B true CN108026515B (zh) 2022-03-11

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US (1) US10392604B2 (https=)
EP (1) EP3382010A4 (https=)
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CN (1) CN108026515B (https=)
AU (1) AU2016350939B9 (https=)
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Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3632433B1 (en) * 2017-05-26 2025-12-24 Vladimir Evgenievich Nebolsin Novel glutaminyl cyclase inhibitors and the use thereof in treatment of various diseases
US12178869B2 (en) * 2017-12-22 2024-12-31 Codagenix Inc. Recombinant virus with codon-pair deoptimized region and uses thereof for the treatment of cancer
WO2019172982A1 (en) 2018-03-08 2019-09-12 Codagenix Inc. Attenuated flaviviruses
CN111315407B (zh) 2018-09-11 2023-05-02 上海市公共卫生临床中心 一种广谱抗流感疫苗免疫原及其应用
KR102370100B1 (ko) * 2019-02-15 2022-03-07 아이디바이오 주식회사 이종 인플루엔자 a 바이러스에 대한 면역/치료반응을 형성하는 신규한 재조합 인플루엔자 바이러스 및 이를 포함하는 유전자 전달체 및 치료백신
RU2726106C1 (ru) * 2019-07-18 2020-07-09 федеральное государственное бюджетное учреждение "Научно-исследовательский институт гриппа имени А.А. Смородинцева" Министерства здравоохранения Российской Федерации (ФГБУ "НИИ гриппа им. А.А. Смородинцева" Минздрава России) Рекомбинантный штамм вируса гриппа A/PR8-NS124-TB10.4-2A-HspX и способ специфической профилактики туберкулеза легких с использованием вакцины мукозального применения на его основе
AU2021342299A1 (en) * 2020-09-11 2023-04-13 The United States Of America, As Represented By The Secretary Of Agriculture Compositions and methods of use thereof for prevention and treatment of influenza infections
US12440553B2 (en) * 2020-11-11 2025-10-14 California Institute Of Technology Multivalent carriers and related vaccine compositions
CN113430178B (zh) * 2021-06-21 2022-10-11 武汉大学 一种表达ii型单纯疱疹病毒蛋白的重组流感病毒株及其制备方法与应用
WO2025041889A1 (ko) * 2023-08-24 2025-02-27 성신여자대학교 연구산학협력단 외래 항원을 발현하는 재조합 인플루엔자 바이러스 벡터 및 이를 포함하는 백신 조성물

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101796190A (zh) * 2007-06-27 2010-08-04 阿维尔绿山生物技术研究发展贸易股份公司 用于表达异源序列的复制缺陷型流感病毒
WO2011014504A1 (en) * 2009-07-27 2011-02-03 Mount Sinai School Of Medicine Of New York University Recombinant influenza virus vectors and uses thereof
CN103068835A (zh) * 2010-06-06 2013-04-24 西奈山医学院 重组rna 病毒及其用途
EP2708552A1 (en) * 2012-09-12 2014-03-19 Medizinische Universität Wien Influenza virus

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4837827B2 (ja) * 1998-06-12 2011-12-14 マウント シナイ スクール オブ メディシン 新規なウイルス増殖方法およびそのためのインターフェロン欠損培養基
DE69937999T2 (de) * 1998-06-12 2009-01-29 Avir Green Hills Biotechnology Research Development Trade Ag Interferon induzierende genetisch veränderte attenuierte viren
WO2001064860A2 (en) * 2000-03-02 2001-09-07 Polymun Scientific Immunbiologische Forschung Gmbh Recombinant influenza a viruses
US7037707B2 (en) * 2003-09-04 2006-05-02 St. Jude Children's Research Hospital Method for generating influenza viruses and vaccines
US7709190B2 (en) * 2005-12-02 2010-05-04 Board Of Regents, The University Of Texas System Influenza A virus vaccines and inhibitors
EP2072058A1 (en) * 2007-12-21 2009-06-24 Avir Green Hills Biotechnology Research Development Trade Ag Modified influenza virus
US8828406B2 (en) * 2009-07-30 2014-09-09 Icahn School Of Medicine At Mount Sinai Influenza viruses and uses thereof
WO2011130652A2 (en) * 2010-04-15 2011-10-20 George Baer Compositions and methods for vaccinating humans and animals against enveloped viruses
EP2646459B1 (en) * 2010-12-02 2020-01-08 Bionor Immuno AS Peptide scaffold design

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101796190A (zh) * 2007-06-27 2010-08-04 阿维尔绿山生物技术研究发展贸易股份公司 用于表达异源序列的复制缺陷型流感病毒
WO2011014504A1 (en) * 2009-07-27 2011-02-03 Mount Sinai School Of Medicine Of New York University Recombinant influenza virus vectors and uses thereof
CN103068835A (zh) * 2010-06-06 2013-04-24 西奈山医学院 重组rna 病毒及其用途
EP2708552A1 (en) * 2012-09-12 2014-03-19 Medizinische Universität Wien Influenza virus

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Attenuation of Equine Influenza Viruses through Truncations of the NS1 Protein";Michelle Quinlivan et al.;《JOURNAL OF VIROLOGY》;20050731;第79卷(第13期);第8431-8439页 *

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