CN107998279A - 一种抗疲劳的宣木瓜膏滋 - Google Patents
一种抗疲劳的宣木瓜膏滋 Download PDFInfo
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- CN107998279A CN107998279A CN201711154295.8A CN201711154295A CN107998279A CN 107998279 A CN107998279 A CN 107998279A CN 201711154295 A CN201711154295 A CN 201711154295A CN 107998279 A CN107998279 A CN 107998279A
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- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
本发明公开了一种具有抗疲劳功效的宣木瓜膏滋，它由如下重量份数的原料制备得到：宣木瓜20‑40份、覆盆子10‑30份、玉竹10‑20份、肉桂15‑25份、桃仁10‑20份和余甘子5‑15份，剂型是膏滋，还公开了制备方法及其在制备具有抗疲劳功效和提高免疫力保健品中的应用。
Description
技术领域
本发明涉及保健品技术领域，具体涉及一种抗疲劳的宣木瓜膏滋及其制备方法和应用。
背景技术
疲劳是一种主观不适感觉，但客观上会在同等条件下，失去其完成原来所从事的正常活动或工作能力。抗疲劳就是通过一些方法手段来抵消这种疲劳的感觉，从而使人感觉轻松有精神。
宣木瓜含有十九种氨基酸、十八种矿物微量元素，以及大量维生素C，同时还含有皂甙、黄酮、苹果酸、齐墩果酸、枸橼酸、柠檬酸、酒石酸、抗坏血酸、反丁烯二酸、鞣质等，含有过氧化氢酶、酚氧化酶、氧化酶，特别富含超氧化物岐化酶(SOD)和齐墩果酸。其SOD的含量是世界上所有水果中无与伦比的，一克宣木瓜鲜果SOD的含量高达3227国际单位。SOD是现代美容养颜产品的核心物质，可以有效消除体内过剩自由基，增进肌体细胞更新。齐墩果酸具有广谱抗菌作用，具有护肝降酶、促免疫、抗炎、降血脂血糖等作用。
发明内容
发明目的：为了解决上述问题，发明人在长期临床试验中意外发现本发明能抗疲劳和提高免疫力，本发明的目的在于提供一种抗疲劳和提高免疫力的宣木瓜膏滋及其制备方法和应用。
技术方案：本发明的目的是通过如下的方案实现的：
一种具有抗疲劳功效的宣木瓜膏滋，它由如下重量份数的原料制备得到：宣木瓜20-40份、覆盆子10-30份、玉竹10-20份、肉桂15-25份、桃仁10-20份和余甘子5-15份。
所述一种具有抗疲劳功效的宣木瓜膏滋，它由如下重量份数的原料制备得到：宣木瓜30份、覆盆子20份、玉竹15份、肉桂20份、桃仁15份和余甘子10份。
所述具有抗疲劳功效的宣木瓜膏滋，所述原料经提取后添加辅料制成膏滋。
所述具有抗疲劳功效的宣木瓜膏滋，制备方法包括如下步骤：取宣木瓜、覆盆子、玉竹、肉桂、桃仁和余甘子合并，加水煎煮两次，合并煎液，浓缩至65℃时相对密度为1.10-1.20，加入乙醇，搅拌，使含醇量按体积百分比计算达65-85％，静置，过滤，滤液减压浓缩至65℃时相对密度为1.20-1.30并回收乙醇得浓缩液，将浓缩液加水及糖浆配制成膏滋。
所述具有抗疲劳功效的宣木瓜膏滋，制备方法中煎煮条件为：第一次加水量为药材重量的8-12倍量，煎煮1-2h，第二次加水量为药材重量的6-10倍量，煎煮1-2h。
所述的宣木瓜膏滋在制备抗疲劳保健品中的应用。
所述的宣木瓜膏滋在制备提高免疫力保健品中的应用。
有益效果：覆盆子为蔷薇科植物华东覆盆子Rubus chingii Hu的干燥果实。分布于江苏、浙江、安徽、福建、江西、广西等地。具有益肾固精缩尿，养肝明目之功效。常用于遗精滑精，遗尿尿频，阳痿早泄，目暗昏花。玉竹为百合科多年生草本植物。根茎横走，肉质黄白色，密生多数须根。叶面绿色，下面灰色。花腋生，通常1～3朵簇生。原产中国西南地区，但野生分布很广。耐寒，亦耐阴，喜潮湿环境，适宜生长于含腐殖质丰富的疏松土壤。《本草经集注》云“茎干强直，似竹箭杆，有节。”故有玉竹之名。植物的根茎可供药用，中药名亦为玉竹，秋季采挖，洗净，晒至柔软后，反复揉搓，晾晒至无硬心，晒干，或蒸透后，揉至半透明，晒干，切厚片或段用。玉竹提取类黄酮物质与桑叶提取物脱氧野尻霉素结合形成一种新物质——洗胰清糖素(cics)，具有降血糖、血脂、血压等作用。肉桂补元阳，暖脾胃，除积冷，通血脉。治命门火衰，肢冷脉微，亡阳虚脱，腹痛泄泻，寒疝奔豚，腰膝冷痛，经闭症瘕，阴疽，流注，及虚阳浮越，上热下寒。桃仁为蔷薇科植物桃Prunus persica(L.)Batsch或山桃Prunusdavidiana(Carr.)Franch.的干燥成熟种子。果实成熟后采收，除去果肉和核壳，取出种子，晒干。全国各地普遍栽培。具有活血祛瘀，润肠通便，止咳平喘的功效。用于经闭痛经，瘕瘕痞块，肺痈肠痈，跌扑损伤，肠燥便秘，咳嗽气喘。余甘子果实富含丰富的丙种维生素，供食用，可生津止渴，润肺化痰，治咳嗽、喉痛，解河豚鱼中毒等。初食味酸涩，良久乃甘，故名“余甘子”。本方中宣木瓜、覆盆子为君药，玉竹、肉桂为臣药，桃仁和余甘子为佐使药，诸药相合，用于缓解体力疲劳和提高免疫力。
具体实施方式
以下通过实施例形式，对本发明的上述内容再作进一步的详细说明，但不应将此理解为本发明上述主题的范围仅限于以下的实例，凡基于本发明上述内容所实现的技术均属于本发明的范围。:
实施例1：取宣木瓜20份、覆盆子30份、玉竹10份、肉桂25份、桃仁10份和余甘子15份药材混合，加水煎煮两次，第一次加水为药材重量的8倍量，煎煮1.5h，第二次加水为药材重量的6倍量，煎煮1h，合并煎液，滤过，滤液浓缩至相对密度1.10(65℃)，加适量乙醇使含醇量(体积分数)达65％，搅拌，静置24小时，滤过，滤液回收乙醇并浓缩至相对密度1.10(65℃)的浸膏，将浓缩液加水及糖浆配制成膏滋。
实施例2：取宣木瓜40份、覆盆子10份、玉竹20份、肉桂15份、桃仁20份和余甘子5份药材混合，加水煎煮两次，第次加水为药材重量的10倍量，煎煮2h，第二次加水为药材重量的8倍量，煎煮1h，合并煎液，滤过，滤液浓缩至相对密度1.15(65℃)，加适量乙醇使含醇量(体积分数)达75％，搅拌，静置24小时，滤过，滤液回收乙醇并浓缩至相对密度1.25(65℃)的浸膏，将浓缩液加水及糖浆配制成膏滋。
实施例3：取宣木瓜30份、覆盆子20份、玉竹15份、肉桂20份、桃仁15份和余甘子10份药材混合，加水煎煮两次，第一次加水为药材重量的12倍量，煎煮2h，第二次加水为药材重量的10倍量，煎煮2h，合并煎液，滤过，滤液浓缩至相对密度1.20(65℃)，加适量乙醇使含醇量(体积分数)达85％，搅拌，静置24小时，滤过，滤液回收乙醇并浓缩至相对密度1.30(65℃)的浸膏，将浓缩液加水及糖浆配制成膏滋。
实施例4：本发明宣木瓜膏滋抗疲劳的药效学研究
实验动物：昆明种小鼠，雄性，体重18-22g，安徽医科大学实验动物中心提供。
实验药物：按上述实施例3的制备方法制备宣木瓜膏滋。低剂量、中剂量和高剂量分别为20ml生药量/kg、40ml生药量/kg和80ml生药量/kg。
阳性药三勒浆抗疲劳液，三勒浆药业集团，卫食健字(2000)第0568号，批号：20150422。即阳性药组给予三勒浆抗疲劳液20ml/kg。
实验过程：选健康小鼠50只，随机分出10只作为正常组，其余40只小鼠，随机分成4组：高剂量组、中剂量组、低剂量组、阳性药三勒浆抗疲劳液组，其中3个剂量组、三勒浆抗疲劳液按上述剂量灌胃给药，正常组给0.2ml的水，每天上午1次，连续30d，进行小鼠负重游泳试验，小鼠尾部负小鼠体重5％的铅皮，放入水温为25℃，水深35cm的游泳箱中，用秒表记录自游泳至力竭死亡的时间，各组数据以均值±标准差表示，组间进行t测验。结果见表。
宣木瓜膏滋对小鼠负重游泳试验的影响(n＝10)
注:同正常组相比*p<0.05**<0.01
结论：本发明宣木瓜膏滋与正常组比较，明显延长小鼠负重游泳时间，说明本发明宣木瓜膏滋具有抗疲劳作用，与阳性药比较，时间延长，说明本发明抗疲劳效果优于阳性药三勒浆抗疲劳液。
实施例5：本发明提高免疫力的药效学研究
实验目的：用本发明实施例1-3制备的宣木瓜膏滋，灌胃小鼠30d，每次0.1ml/10g，比较本发明和正常组小鼠受ConA诱导的脾脏淋巴细胞增殖的差别，来判断本发明宣木瓜膏滋是否增强脾脏淋巴细胞增殖。
实验动物：昆明种小鼠，雄性，体重18-22g，本公司提供。
实验步骤：小鼠，按体重分层随机分组,每组10只。如下表所示，正常组灌胃给水；盐酸左旋咪唑组灌胃盐酸左旋咪唑；实施例1-3灌胃2g·kg-1，各组连续灌胃给药30d。无菌取脾，按照常规制成单个细胞悬液，调整细胞浓度为5×105个/mL。将脾细胞混悬液加在24孔板中，每孔1mL，每只动物设二个复孔，一孔正常培养(加50uL PRMI1640培养液)；一孔加50uLR刀豆蛋白A(ConA)液(终浓度为4.76ug/mL)。置于5％CO2，37℃CO2孵箱中培养48h。实验结束前4h，每孔吸去上清液700uL，再加入700uL不含胎牛血清的PRMI1640培养液，同时每孔加入50uL5mg/mL的MTT液。培养结束后，每孔加1mL酸性异丙醇，小心吹打均匀至紫色的结晶全部溶解。检测前分装到96孔培养板中，每孔作4个复孔，在570nm波长处测定其光密度值。
实验结果：
本发明宣木瓜膏滋对脾淋巴细胞增殖的影响
注：与正常组相比★★P＜0.01，★P＜0.05。
结论：本发明实施例1-3宣木瓜膏滋小鼠脾脏淋巴细胞受ConA诱导后的增殖率转化值高于正常组小鼠，说明本发明宣木瓜膏滋具有提高免疫力作用。
Claims (7)
1.一种具有抗疲劳功效的宣木瓜膏滋，其特征在于，它由如下重量份数的原料制备得到：宣木瓜20-40份、覆盆子10-30份、玉竹10-20份、肉桂15-25份、桃仁10-20份和余甘子5-15份。
2.如权利要求1所述一种具有抗疲劳功效的宣木瓜膏滋，其特征在于，它由如下重量份数的原料制备得到：宣木瓜30份、覆盆子20份、玉竹15份、肉桂20份、桃仁15份和余甘子10份。
3.如权利要求1或2所述具有抗疲劳功效的宣木瓜膏滋，其特征在于，所述原料经提取后添加辅料制成膏滋。
4.根据权利要求1或2所述具有抗疲劳功效的宣木瓜膏滋，其特征在于，制备方法包括如下步骤：取宣木瓜、覆盆子、玉竹、肉桂、桃仁和余甘子合并，加水煎煮两次，合并煎液，浓缩至65℃时相对密度为1.10-1.20，加入乙醇，搅拌，使含醇量按体积百分比计算达65-85％，静置，过滤，滤液减压浓缩至65℃时相对密度为1.20-1.30并回收乙醇得浓缩液，将浓缩液加糖浆配制成膏滋。
5.如权利要求4所述具有抗疲劳功效的宣木瓜膏滋，其特征在于，制备方法中煎煮条件为：第一次加水量为药材重量的8-12倍量，煎煮1-2h，第二次加水量为药材重量的6-10倍量，煎煮1-2h。
6.如权利要求1或2所述的宣木瓜膏滋在制备抗疲劳保健品中的应用。
7.如权利要求1或2所述的宣木瓜膏滋在制备提高免疫力保健品中的应用。
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| CN107320631A (zh) * | 2017-08-02 | 2017-11-07 | 北京胡记堂医药科技中心 | 一种抗疲劳中药组合物及其制备方法 |
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| CN102258680A (zh) * | 2011-07-17 | 2011-11-30 | 南京苏美瑞医药科技有限公司 | 一种缓解体力疲劳的中药组合物及其制备方法和应用 |
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