CN107998257A - A kind of Chinese medicine composition for treating enterohepatitis and preparation method and application - Google Patents
A kind of Chinese medicine composition for treating enterohepatitis and preparation method and application Download PDFInfo
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Abstract
A kind of Chinese medicine composition for treating enterohepatitis, it is characterised in that include the raw material of following weight proportion：Gamboge 13, rhizome of cyrtomium 5 10, gemma agrimoninae 8 12, Chinese prickly ash 5 10, aloe 10 15.The compatibility of Chinese medicine composition of the present invention is reasonable, using gamboge, rhizome of cyrtomium is clearing heat and detoxicating, antibacterial desinsection is monarch drug in a prescription, using gemma agrimoninae, Chinese prickly ash expelling parasite desinsection as ministerial drug, aloe, the root of Dahurain angelica, the radix paeoniae rubrathe, subprostrate sophora clearing liver, cool blood, swelling and pain relieving are assistant with it, the seed of Oriental arborvitae, cortex albiziae spleen-benefiting mind-tranquilizing are to make medicine, all medicines share has the effect of clearing heat and detoxicating, desinsection, cooling blood and relieving pain, calm emotions, can effectively treat chicken tissues trichomoniasis.At the same time, the preparation method of Chinese medicine composition of the present invention is easy to operate, substep obtains the decocting liquid of gamboge water extract, rhizome of cyrtomium alcohol hypostasis, gemma agrimoninae zymolyte and other raw medicinal materials, obtains the active ingredient of wherein treatment of tissue trichomoniasis, has reached the good result for the treatment of of tissue trichomoniasis.
Description
Technical field
The invention belongs to the field of Chinese medicines, and in particular to a kind of Chinese medicine composition for treating enterohepatitis and its preparation
Method and application.
Background technology
Histomoniasis (Histomoniasis) is also referred to as blackhead or blackhead disease, it is the turkey by Histomonas
Tissue trichomonad parasitizes a kind of protozoosis caused by birds caecum and liver, using the heterakid of chicken or earthworm as communication media.
Main infringement caecum and liver, are mainly in chick and poult, Adult Chicken can also infect, but the state of an illness is lighter；Pheasant, peacock, pearl
Chicken, quail etc. can also infect sometimes.Fowl ingest heterakid ovum pollution feed and drinking-water and infect, also can be because ingesting with different thorn
The earthworm of line eggs and larva and infect.
At present, the treatment for histomoniasis uses chemical drugs more, such as Dimetridazole, flagyl metronidazole, chlorine
Benzene guanidine etc. is treated, and not only treatment cycle is grown, but also easily produces medicament residue, and very big threat is caused to poultry husbandry.
The content of the invention
The technical problems to be solved in view of the defects of the present invention is to propose a kind of reasonable recipe, effect to show
Write the Chinese medicine composition for the treatment of enterohepatitis.
Another technical problem to be solved by this invention there is provided treatment enterohepatitis as described above
The preparation method of Chinese medicine composition.
Present invention also offers above-mentioned Chinese medicine composition to prepare the application in treating enterohepatitis.
The technical problem to be solved in the present invention is what is be achieved through the following technical solutions, and one kind treats Histomanas Meleagridis
The Chinese medicine composition of disease, its main feature is that, include the raw material of following weight proportion：Gamboge 1-3, rhizome of cyrtomium 5-10, gemma agrimoninae 8-12, flower
Green pepper 5-10, aloe 10-15.
In the Chinese medicine composition technical solution of above-described treatment enterohepatitis, which further includes
The raw material of following weight proportion：Root of Dahurain angelica 4-11, radix paeoniae rubrathe 5-15, subprostrate sophora 5-10, seed of Oriental arborvitae 8-12, cortex albiziae 5-10.
In the Chinese medicine composition technical solution of above-described treatment enterohepatitis, the weight proportion of each raw material
For：Gamboge 1-2, rhizome of cyrtomium 6-8, gemma agrimoninae 8-10, Chinese prickly ash 6-8, aloe 11-14, root of Dahurain angelica 5-10, radix paeoniae rubrathe 6-12, subprostrate sophora 6-8,
Seed of Oriental arborvitae 8-10, cortex albiziae 6-9.It is further preferred that the weight proportion of each raw material is：Gamboge 1, rhizome of cyrtomium 8, gemma agrimoninae 10, flower
Green pepper 6, aloe 14, the root of Dahurain angelica 6, the radix paeoniae rubrathe 6, subprostrate sophora 8, the seed of Oriental arborvitae 10, cortex albiziae 8.
Present invention also offers the preparation method of the Chinese medicine composition described in above technical scheme, its main feature is that, including such as
Lower step：
(1) take gamboge to be freeze-dried, crush, add water, closed decoction, centrifugation, takes supernatant concentration, obtain gamboge water and carry
Thing；
(2) rhizome of cyrtomium is shredded, adds water, decocted, filtering, collects filtrate, and ethanol is added into filtrate and carries out alcohol precipitation, and it is heavy to collect
Form sediment, obtain rhizome of cyrtomium water extracting alcohol hypostasis；
(3) gemma agrimoninae is shredded, adds water to be homogenized, obtain homogenate, cellulase is added into homogenate, digested, in collection
Layer enzymolysis liquid, concentration, obtains gemma agrimoninae zymolyte；
(4) remaining material medicinal material is shredded or crushed respectively, mixed, add water, soaked, decocted, filtering, obtains decocting liquid and filter
Slag, filter residue are decocted 2-3 times with water again, and filtering, discards filter residue, merge each secondary decocting liquid, obtain mixing decocting liquid；
(5) take gamboge water extract, rhizome of cyrtomium water extracting alcohol hypostasis, gemma agrimoninae zymolyte and mixing decocting liquid to be uniformly mixed, depressurize
Concentration, obtains concentrate that at 65-75 DEG C relative density is 1.1-1.2.
In the preparation method of Chinese medicine composition of the present invention, further preferred technical solution or technical characteristic
It is：
1st, in step (1)：Add water into goa powder by material water weight ratio 1: 5-10, closed decoction 2-3h, centrifugation, takes
Clear liquid concentrates, and obtains gamboge water extract.
2nd, in step (2)：Rhizome of cyrtomium is shredded, adds water thereto by material water weight ratio 1: 8-15, decocts 1-2h, filter,
Filtrate is collected, 80-90% ethanol is added into filtrate, reaches 60-75% to determining alcohol, stirs, is stood, it is heavy to collect
Form sediment, obtain rhizome of cyrtomium water extracting alcohol hypostasis.
3rd, in step (3)：Gemma agrimoninae is shredded, then adds water to be homogenized by material water weight ratio 1: 2-6, obtains homogenate, Xiang Yun
The cellulase for accounting for homogenate weight 0.5-1.5% is added in slurries, digests 3-5.5h, collects upper strata enzymolysis liquid, concentration, obtains
Gemma agrimoninae zymolyte.
4th, in step (4)：Remaining material medicinal material is shredded or crushed respectively, is mixed, is added into mixed material medicine mixed
Bulk pharmaceutical chemicals 8-10 times of water measured of gross weight is closed, water temperature is 35-45 DEG C, soaks 2-5h, intense fire is boiled to boiling, and 20- is maintained after boiling
30min, then with 0.5-1h is cooked by slow fire, filter, decocting liquid and filter residue are obtained, filter residue is decocted 2-3 times with the water of 3-6 times of weight again,
Each 2-3h, filtering, discards filter residue, merges each secondary decocting liquid, obtains mixing decocting liquid.
Application of the Chinese medicine composition of the present invention in the medicine for preparing treatment enterohepatitis.
The pharmacological property of Chinese medicine material of the present invention is as follows：
Gamboge：Cool, acid is puckery, poisonous；Major function：Detumescence, attacks poison, stops blooding, desinsection, rotten sword sore of dispelling, main swollen ulcer drug,
Ulcer, wet sore, swell tinea, stubborn dermatitis, treating swelling and pain by traumatic injury, traumatic bleeding and scald.
Rhizome of cyrtomium：It is cold, it is bitter, it is slightly poisonous；Major function：It is clearing heat and detoxicating, hemostasis, desinsection.For cold, fever, dysentery is damp and hot,
Sore, has blood in stool, hematuria, menorrhalgia, knife wound bleeding, roundworm, rich worm, taeniasis, induced abortion, postpartum haemorrhage.
Gemma agrimoninae：It is slightly cold, it is bitter；Return liver, small intestine, large intestine channel；Major function：Desinsection, for tapeworm disease.
Chinese prickly ash：Temperature, it is pungent；Returns spleen, stomach, kidney channel；Major function：Warm in pain, desinsection is antipruritic, for coldness and pain in the epigastrium, vomiting
Diarrhea, abdominal pain due to enterositosis, ascariasis, controls eczema itch outside.
Aloe：It is cold, it is bitter；Return liver, large intestine channel；Major function：Under rushing down, clear liver, desinsection, main constipation with heat retention, irascibility headache, mesh
Red infantile convulsion, abdominal pain due to enterositosis, mange, hemorrhoid complicated by anal fistula, solution crotons poison.
The root of Dahurain angelica：Temperature, it is pungent；Channel tropism returns stomach, large intestine, lung channel；Major function：Relieve heat dehumidifies, sensible analgesic, detumescence and apocenosis, uses
In cold headache, pain in the supra-orbital bone, nasal obstruction, nasosinusitis, toothache, leukorrhea, sore swell and ache curative.
The radix paeoniae rubrathe：It is slightly cold, it is bitter；Return liver warp；Major function：Clearing heat and cooling blood, removing blood stasis and analgesics, for febrile virulent maculae, hematemesis and epistaxis,
Red eye, swell pain, liver-depressed hypochondrium pain, closed dysmenorrhea, abdominal mass abdominal pain, injury from falling down, carbuncle swells sore.
Subprostrate sophora：It is cold, it is bitter, it is poisonous；Attach to the lung and stomach meridians；Major function：It is clearing heat and detoxicating, swelling and pain relieving, defaecation, acute sore throat
Inflammation, tonsillitis, gingival swelling and pain, cough with lung heat, jaundice with damp-heat pathogen, carbuncle furuncle poison constipation.
The seed of Oriental arborvitae：It is mild-natured, it is sweet；The thoughts of returning home, kidney, large intestine channel；Major function：Mental-tranquilization, arrest sweating, relaxes bowel, main palpitation with fear
Palpitation, insomnia forgetfulness, night sweat, dry constipation of intestines.
Cortex albiziae：It is mild-natured, it is sweet；Return liver, the heart, the spleen channel；Major function：Calm the nerves, Xie Yu, promoting blood circulation, analgesic, continuous muscles and bones, the main heart
It is refreshing uneasy, melancholy insomnia, lung carbuncle, injured bones and muscles, anal fistula pain.
Compared with prior art, the present invention prescription compatibility is reasonable, using gamboge, rhizome of cyrtomium is clearing heat and detoxicating, antibacterial desinsection as monarch drug in a prescription,
Using gemma agrimoninae, Chinese prickly ash expelling parasite desinsection as ministerial drug, aloe, the root of Dahurain angelica, the radix paeoniae rubrathe, subprostrate sophora clearing liver, cool blood, swelling and pain relieving are assistant with it,
To make medicine, all medicines share has clearing heat and detoxicating, desinsection, cooling blood and relieving pain, the work(of calm emotions for the seed of Oriental arborvitae, cortex albiziae spleen-benefiting mind-tranquilizing
Effect, can effectively treat chicken tissues trichomoniasis.Meanwhile the preparation method of Chinese medicine composition of the present invention is easy to operate, obtains step by step
Gamboge water extract, rhizome of cyrtomium alcohol hypostasis, the decocting liquid of gemma agrimoninae zymolyte and other raw medicinal materials, obtain wherein treatment of tissue
The active ingredient of trichomoniasis, has reached the good result for the treatment of of tissue trichomoniasis.
Chinese medicine composition of the present invention drips in addition to the treatment that can be used for enterohepatitis, to other with tissue
The birds of parasitosis, such as pheasant, galeeny, quail are respectively provided with good therapeutic effect.
Embodiment
With reference to specific embodiment, the present invention is described in further detail, but embodiments of the present invention are not only
It is limited to this.
Embodiment 1, a kind of Chinese medicine composition for treating enterohepatitis, includes the raw material of following weight proportion：Rattan
Huang 1, rhizome of cyrtomium 5, gemma agrimoninae 8, Chinese prickly ash 5, aloe 10.
Embodiment 2, a kind of Chinese medicine composition for treating enterohepatitis, includes the raw material of following weight proportion：Rattan
Huang 3, rhizome of cyrtomium 10, gemma agrimoninae 12, Chinese prickly ash 10, aloe 15.
Embodiment 3, in the Chinese medicine composition of the treatment enterohepatitis described in embodiment 1 or 2, further includes following heavy
Measure the raw material of proportioning：The root of Dahurain angelica 4, the radix paeoniae rubrathe 5, subprostrate sophora 5, the seed of Oriental arborvitae 8, cortex albiziae 5.
Embodiment 4, in the Chinese medicine composition of the treatment enterohepatitis described in embodiment 1 or 2, further includes following heavy
Measure the raw material of proportioning：The root of Dahurain angelica 11, the radix paeoniae rubrathe 15, subprostrate sophora 10, the seed of Oriental arborvitae 12, cortex albiziae 10.
Embodiment 5, in the Chinese medicine composition of the treatment enterohepatitis described in embodiment 3 or 4, the weight of each raw material
Measuring proportioning is：Gamboge 1, rhizome of cyrtomium 6, gemma agrimoninae 8, Chinese prickly ash 6, aloe 11, the root of Dahurain angelica 5, the radix paeoniae rubrathe 6, subprostrate sophora 6, the seed of Oriental arborvitae 8, cortex albiziae
6。
Embodiment 6, in the Chinese medicine composition of the treatment enterohepatitis described in embodiment 3 or 4, the weight of each raw material
Measuring proportioning is：Gamboge 2, rhizome of cyrtomium 8, gemma agrimoninae 10, Chinese prickly ash 8, aloe 14, the root of Dahurain angelica 10, the radix paeoniae rubrathe 12, subprostrate sophora 8, the seed of Oriental arborvitae 10, is closed
Joyous skin 9.
Embodiment 7, the preparation method of the Chinese medicine composition described in embodiment 1-6 any one, includes the following steps：
(1) take gamboge to be freeze-dried, crush, add water, closed decoction, centrifugation, takes supernatant concentration, obtain gamboge water and carry
Thing；
(2) rhizome of cyrtomium is shredded, adds water, decocted, filtering, collects filtrate, and ethanol is added into filtrate and carries out alcohol precipitation, and it is heavy to collect
Form sediment, obtain rhizome of cyrtomium water extracting alcohol hypostasis；
(3) gemma agrimoninae is shredded, adds water to be homogenized, obtain homogenate, cellulase is added into homogenate, digested, in collection
Layer enzymolysis liquid, concentration, obtains gemma agrimoninae zymolyte；
(4) remaining material medicinal material is shredded or crushed respectively, mixed, add water, soaked, decocted, filtering, obtains decocting liquid and filter
Slag, filter residue are decocted 2-3 times with water again, and filtering, discards filter residue, merge each secondary decocting liquid, obtain mixing decocting liquid；
(5) take gamboge water extract, rhizome of cyrtomium water extracting alcohol hypostasis, gemma agrimoninae zymolyte and mixing decocting liquid to be uniformly mixed, depressurize
Concentration, obtains concentrate that at 65 DEG C relative density is 1.1.
Embodiment 8, the preparation method of the Chinese medicine composition described in embodiment 1-6 any one, includes the following steps：
(1) take gamboge to be freeze-dried, crush, add water, closed decoction, centrifugation, takes supernatant concentration, obtain gamboge water and carry
Thing；
(2) rhizome of cyrtomium is shredded, adds water, decocted, filtering, collects filtrate, and ethanol is added into filtrate and carries out alcohol precipitation, and it is heavy to collect
Form sediment, obtain rhizome of cyrtomium water extracting alcohol hypostasis；
(3) gemma agrimoninae is shredded, adds water to be homogenized, obtain homogenate, cellulase is added into homogenate, digested, in collection
Layer enzymolysis liquid, concentration, obtains gemma agrimoninae zymolyte；
(4) remaining material medicinal material is shredded or crushed respectively, mixed, add water, soaked, decocted, filtering, obtains decocting liquid and filter
Slag, filter residue are decocted 2-3 times with water again, and filtering, discards filter residue, merge each secondary decocting liquid, obtain mixing decocting liquid；
(5) take gamboge water extract, rhizome of cyrtomium water extracting alcohol hypostasis, gemma agrimoninae zymolyte and mixing decocting liquid to be uniformly mixed, depressurize
Concentration, obtains concentrate that at 75 DEG C relative density is 1.2.
In the step of embodiment 9, preparation method described in embodiment 7 or 8 (1), by material water weight ratio 1: 5 into goa powder
Add water, closed decoction 2h, centrifugation, takes supernatant concentration, obtain gamboge water extract.
In the step of embodiment 10, preparation method described in embodiment 7 or 8 (1), by material water weight ratio 1: 12 to goa powder
In plus water, closed decoction 3h, centrifugation, take supernatant concentration, obtain gamboge water extract.
In the step of embodiment 11, preparation method described in embodiment 7 or 8 (2), rhizome of cyrtomium is shredded, by material water weight ratio 1
: 8 add water thereto, decoct 1h, filtering, collects filtrate, 80% ethanol is added into filtrate, reaches 60% to determining alcohol, fully
Stir evenly, stand, collect precipitation, obtain rhizome of cyrtomium water extracting alcohol hypostasis.
In the step of embodiment 12, preparation method described in embodiment 7 or 8 (2), rhizome of cyrtomium is shredded, by material water weight ratio 1
: 15 add water thereto, decoct 2h, filtering, collects filtrate, 90% ethanol is added into filtrate, reaches 75% to determining alcohol, fully
Stir evenly, stand, collect precipitation, obtain rhizome of cyrtomium water extracting alcohol hypostasis.
In the step of embodiment 13, preparation method described in embodiment 7 or 8 (3), gemma agrimoninae is shredded, then by material water weight
Amount is than 1: 2 plus water is homogenized, and obtains homogenate, the cellulase for accounting for homogenate weight 0.5% is added into homogenate, digest 3h, receive
Collect upper strata enzymolysis liquid, concentration, obtains gemma agrimoninae zymolyte.
In the step of embodiment 14, preparation method described in embodiment 7 or 8 (3), gemma agrimoninae is shredded, then by material water weight
Amount is than 1: 6 plus water is homogenized, and obtains homogenate, the cellulase for accounting for homogenate weight 1.5% is added into homogenate, digest 5.5h,
Upper strata enzymolysis liquid is collected, concentration, obtains gemma agrimoninae zymolyte.
In the step of embodiment 15, preparation method described in embodiment 7 or 8 (4), remaining material medicinal material is shredded respectively or
Crush, mixing, the water of 8 times of amounts of mixed material medicine gross weight is added into mixed material medicine, water temperature is 35 DEG C, soaks 2h, intense fire
Boil to boiling, 20min is maintained after boiling, then with 0.5h is cooked by slow fire, filters, obtain decocting liquid and filter residue, filter residue is again with 3 weight
Water again decocts 2 times, each 2h, and filtering, discards filter residue, merges each secondary decocting liquid, obtains mixing decocting liquid.
In the step of embodiment 16, preparation method described in embodiment 7 or 8 (4), remaining material medicinal material is shredded respectively or
Crush, mixing, the water of 10 times of amounts of mixed material medicine gross weight is added into mixed material medicine, water temperature is 45 DEG C, soaks 5h, intense fire
Boil to boiling, 30min is maintained after boiling, then with 1h is cooked by slow fire, filters, obtain decocting liquid and filter residue, filter residue is again with 6 times of weight
Water decoct 3 times, each 3h, filtering, discards filter residue, merges each secondary decocting liquid, obtains mixing decocting liquid.
Embodiment 17, a kind of Chinese medicine composition for treating enterohepatitis, includes the raw material of following weight proportion：Rattan
Huang 1.5, rhizome of cyrtomium 10, gemma agrimoninae 8, Chinese prickly ash 10, aloe 10.
The preparation method of the Chinese medicine composition includes the following steps：
(1) take gamboge to be freeze-dried, be crushed to 150 mesh, add water, closed decoction into goa powder by material water weight ratio 1: 8
3h, centrifugation, takes supernatant concentration, obtains gamboge water extract；
(2) rhizome of cyrtomium is shredded, adds water thereto by material water weight ratio 1: 12, decoct 2h, filtering, collects filtrate, to filtrate
85% ethanol of middle addition, reaches 60% to determining alcohol, stirs, and stands, and collects precipitation, obtains rhizome of cyrtomium water extract-alcohol precipitation
Thing；
(3) gemma agrimoninae is shredded, then by material water weight ratio 1: 4 plus water homogenate, obtains homogenate, added into homogenate account for it is even
The cellulase of slurry weight 1%, digests 4h, collects upper strata enzymolysis liquid, concentration, obtains gemma agrimoninae zymolyte；
(4) remaining material medicinal material is shredded or crushed respectively, mixed, mixed material medicine gross weight is added into mixed material medicine
The water of 8 times of amounts of amount, water temperature are 40 DEG C, soak 4h, and intense fire boiled to boiling, maintain 25min after boiling, then with being cooked by slow fire 0.8h,
Filtering, obtains decocting liquid and filter residue, and filter residue is decocted 2-3 times, each 2h with the water of 4 times of weight again, and filtering, discards filter residue, is merged each
Secondary decocting liquid, obtains mixing decocting liquid；
(5) take gamboge water extract, rhizome of cyrtomium water extracting alcohol hypostasis, gemma agrimoninae zymolyte and mixing decocting liquid to be uniformly mixed, depressurize
Concentration, it is Chinese medicine composition of the present invention to obtain the concentrate that the relative density at 70 DEG C is 1.15.
Embodiment 18, a kind of Chinese medicine composition for treating enterohepatitis, includes the raw material of following weight proportion：Rattan
Huang 1, rhizome of cyrtomium 8, gemma agrimoninae 10, Chinese prickly ash 6, aloe 14, the root of Dahurain angelica 6, the radix paeoniae rubrathe 6, subprostrate sophora 8, the seed of Oriental arborvitae 10, cortex albiziae 8；
The preparation method of the Chinese medicine composition is the same as embodiment 17.
Chinese medicine composition of the present invention by the 0.02-0.05% of turkey weights by it in use, admix chicken feed, for suffering from chicken feed
With, or in every 1 ton of chicken drinking water Chinese medicine composition 1.5-2.0g of the present invention is added, it is oral by drinking water, 2 times a day, sooner or later respectively
Once, continuous use 2-3 days.
Embodiment 18, test example.
1st, experimental animal
Lianyungang Donghai County turkey farm, can be integrated according to clinical symptoms, pathology dissect and micrography
Diagnosis, will be diagnosed as the turkey of histomoniasis as test chicken.
To suffer from chicken and just show that dull, spirit is depressed, feeding is reduced or stopped, and loose random, wing are sagging, and walking is such as paddled sample,
Skin of head bluish violet, cold crowded heap, blood stool or yellow green.Pathology dissect is shown in caecum severe haemorrhage, and intestinal contents is in blood
Grumeleuse, caecum wall thickness, hypertrophy, crosscutting caecum section are in concentric layered shell polysaccharide more；Liver enlargement, surface have circular or irregular shape to sink
Necrotic area, color is yellowish or how much pale green, marginal swell, ulcer stove differ.Laboratory examination, sterile working take morbidity chicken fresh
Intestinal contents, after normal saline dilution, is made hanging drop preparation, it is seen that in the protozoon body of pendulum back and forth movement.
2nd, test method
Chinese medicine composition group 1 of the present invention：The Chinese medicine composition being prepared using the embodiment of the present invention 17, by turkey weights
0.02% admix feed, continuous use 3 days；
Chinese medicine composition group 2 of the present invention：The Chinese medicine composition being prepared using the embodiment of the present invention 17, by turkey weights
0.05% admix feed, continuous use 3 days；
Chinese medicine composition group 3 of the present invention：The Chinese medicine composition being prepared using the embodiment of the present invention 18, every 1 ton of chicken drink
1.5g is added with water, continuous use 3 day oral by drinking water；
Chinese medicine composition group 4 of the present invention：The Chinese medicine composition being prepared using the embodiment of the present invention 18, every 1 ton of chicken drink
2.0g is added with water, continuous use 3 day oral by drinking water；
Control drug group：Metronidazole (GuangDong HuaNan Pharmacy Group Co., Ltd produces, lot number 20161201), according to
Specification uses, continuous use 3 days；
Blank control group：Not medication.
Test turkey and feed amount every time to slightly have clout in feed trough after having enough as degree, free water.
4th, effect observation
4.1 cure
After continuous use 3d, clinical symptoms disappear, and pathology dissect recovers normal without obvious lesion, spirit, feeding, drinking-water.
It is 4.2 invalid
After continuous use 3d, clinical symptoms continue to aggravate, and pathology dissect has obvious lesion, and spirit, feeding, drinking-water are the same as treatment
Before.
5th, result of the test
According to above-mentioned observing effect, calculate cure rate, inefficiency and the death rate, result of the test and be shown in Table 1.
1. animal test results of table
| Group | Cure rate/% | Inefficiency/% | The death rate/% |
| Chinese traditional medicine composition group 1 of the present invention | 88.4 | 7.2 | 4.4 |
| Chinese traditional medicine composition group 2 of the present invention | 90.5 | 5.9 | 3.6 |
| Chinese traditional medicine composition group 3 of the present invention | 92.2 | 4.8 | 3.0 |
| Chinese traditional medicine composition group 4 of the present invention | 93.7 | 3.5 | 2.8 |
| Control drug group | 81.4 | 7.9 | 10.7 |
| Blank control group | - | - | 18.3 |
From experimental result, compared with control drug group, the therapeutic effect of Chinese medicine composition of the present invention is more notable.Together
When, the increase root of Dahurain angelica, the radix paeoniae rubrathe, subprostrate sophora, the seed of Oriental arborvitae, 5 taste medicine of cortex albiziae play synergistic function in prescription, are prepared
Traditional Chinese medicine composition for treating enterohepatitis effect it is more preferable.
Claims (10)
1. a kind of Chinese medicine composition for treating enterohepatitis, it is characterised in that include the raw material of following weight proportion：Rattan
Yellow 1-3, rhizome of cyrtomium 5-10, gemma agrimoninae 8-12, Chinese prickly ash 5-10, aloe 10-15.
2. the Chinese medicine composition for the treatment of enterohepatitis according to claim 1, it is characterised in that further include following
The raw material of weight proportion：Root of Dahurain angelica 4-11, radix paeoniae rubrathe 5-15, subprostrate sophora 5-10, seed of Oriental arborvitae 8-12, cortex albiziae 5-10.
3. the Chinese medicine composition for the treatment of enterohepatitis according to claim 2, it is characterised in that the weight of each raw material
Measuring proportioning is：Gamboge 1-2, rhizome of cyrtomium 6-8, gemma agrimoninae 8-10, Chinese prickly ash 6-8, aloe 11-14, root of Dahurain angelica 5-10, radix paeoniae rubrathe 6-12, mountain beans
Root 6-8, seed of Oriental arborvitae 8-10, cortex albiziae 6-9.
4. the Chinese medicine composition for the treatment of enterohepatitis according to claim 3, it is characterised in that the weight of each raw material
Measuring proportioning is：Gamboge 1, rhizome of cyrtomium 8, gemma agrimoninae 10, Chinese prickly ash 6, aloe 14, the root of Dahurain angelica 6, the radix paeoniae rubrathe 6, subprostrate sophora 8, the seed of Oriental arborvitae 10, silk tree
Skin 8.
5. the preparation method of a kind of Chinese medicine composition as described in claim 1-4 any one, it is characterised in that including as follows
Step：
（1）Take gamboge to be freeze-dried, crush, add water, closed decoction, centrifugation, takes supernatant concentration, obtain gamboge water extract；
（2）Rhizome of cyrtomium is shredded, adds water, is decocted, filtering, collects filtrate, and ethanol is added into filtrate and carries out alcohol precipitation, collects precipitation,
Obtain rhizome of cyrtomium water extracting alcohol hypostasis；
（3）Gemma agrimoninae is shredded, adds water to be homogenized, obtains homogenate, cellulase is added into homogenate, is digested, collects upper strata enzyme
Liquid is solved, concentration, obtains gemma agrimoninae zymolyte；
（4）Remaining material medicinal material is shredded or crushed respectively, mixes, adds water, is soaked, is decocted, filtering, obtains decocting liquid and filter residue,
Filter residue is decocted 2-3 times with water again, and filtering, discards filter residue, merges each secondary decocting liquid, obtains mixing decocting liquid；
（5）Take gamboge water extract, rhizome of cyrtomium water extracting alcohol hypostasis, gemma agrimoninae zymolyte and mixing decocting liquid to be uniformly mixed, be concentrated under reduced pressure,
Obtain concentrate that at 65-75 DEG C relative density is 1.1-1.2.
6. preparation method according to claim 5, it is characterised in that in step（1）In：By material water weight ratio 1:5-10 to
Add water in goa powder, closed decoction 2-3h, centrifugation, takes supernatant concentration, obtain gamboge water extract.
7. preparation method according to claim 5, it is characterised in that in step（2）In：Rhizome of cyrtomium is shredded, by material water weight
Measure ratio 1:8-15 adds water thereto, decocts 1-2h, and filtering, collects filtrate, and 80-90% ethanol is added into filtrate, is reached to determining alcohol
To 60-75%, stir, stand, collect precipitation, obtain rhizome of cyrtomium water extracting alcohol hypostasis.
8. preparation method according to claim 5, it is characterised in that in step（3）In：Gemma agrimoninae is shredded, then by material
Water weight ratio 1:2-6 adds water to be homogenized, and obtains homogenate, and the cellulase for accounting for homogenate weight 0.5-1.5% is added into homogenate,
3-5.5h is digested, collects upper strata enzymolysis liquid, concentration, obtains gemma agrimoninae zymolyte.
9. preparation method according to claim 5, it is characterised in that in step（4）In：Remaining material medicinal material is cut respectively
Broken or crushing, mixing, mixed material medicine 8-10 times of water measured of gross weight is added into mixed material medicine, and water temperature is 35-45 DEG C, leaching
2-5h is steeped, intense fire is boiled to boiling, 20-30min is maintained after boiling, then with 0.5-1h is cooked by slow fire, filters, obtain decocting liquid and filter
Slag, filter residue are decocted 2-3 times, each 2-3h with the water of 3-6 times of weight again, and filtering, discards filter residue, merges each secondary decocting liquid, obtains
Mix decocting liquid.
10. a kind of Chinese medicine composition as described in claim 1-4 any one is preparing the medicine for the treatment of enterohepatitis
Application in thing.
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| CN116474014A (en) * | 2023-04-28 | 2023-07-25 | 河北锦坤动物药业有限公司 | Traditional Chinese medicine composition for treating chicken histomonas and preparation method thereof |
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| US5061491A (en) * | 1988-12-30 | 1991-10-29 | Deryabin Alexandr M | Medicinal agent and method for treatment of mastitis in animals and humans |
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| CN116474014A (en) * | 2023-04-28 | 2023-07-25 | 河北锦坤动物药业有限公司 | Traditional Chinese medicine composition for treating chicken histomonas and preparation method thereof |
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