CN107982350A - One kind treats cold Chinese medicine composition and preparation method thereof - Google Patents
One kind treats cold Chinese medicine composition and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/17—Gnetophyta, e.g. Ephedraceae (Mormon-tea family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/808—Scrophularia (figwort)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The present invention provides one kind to treat cold Chinese medicine composition and preparation method thereof, the Chinese medicine composition is made of cassia twig, almond, radix glycyrrhizae, Chinese ephedra, it is used to treat flu and caused dizziness, aches with it, weakness of limbs symptom effect highly significant, through on probation, its efficient up to 100%, cure rate more than 95% that is used to treating flu of Chinese medicine composition of the present invention.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to one kind treats cold Chinese medicine composition and preparation method thereof.
Background technology
Flu is a kind of frequently-occurring disease, its primary symptom show as it is dizzy, ache with it, weakness of limbs etc., be by Respirovirus
It is caused.The flu traditional Chinese medical science claims cold-dampness to join the army, and is commonly called as catching cold, and no matter this disease is generated heat or do not generated heat all without perspiration, after a period of time
Can self-healing, so it is believed that this disease is not disease.But either disease is not disease, and ill symptom is always uncomfortable, no
Cure in time, delay treatment opportunity is also possible to trigger other health problems, such as：Prevent human body immunity degradation, without spirit from
Pleasant live and work；Trigger the generation of various diseases.For cold drug on the market based on Western medicine, Chinese medicine is few now
Molding Chinese medicine preparation, Chinese medicine preparation is unreasonable, and therapeutic effect is undesirable.
It discloses Chinese ephedra for the patent No. " CN201410520944.1 " patent name " a kind of Chinese medicine preparation for treating flu "
8-12g, cassia twig 8-12g；Almond 8-12g；Radix glycyrrhizae 3-7g prescriptions, which are used to treat, catches a cold, it is used to treat aversion to cold, fever, nasal obstruction
The symptom effect such as runny nose be also possible that but for it is dizzy, ache with it, weakness of limbs effect it is not notable enough, drug effect is not definite enough.
The content of the invention
Based on above-mentioned discussion, the present invention provides one kind to treat cold Chinese medicine composition and preparation method thereof, the Chinese medicine group
Compound is made of cassia twig, almond, radix glycyrrhizae, Chinese ephedra, cordate houttuynia, blackberry lily, it is used to treating flu and caused dizzy, sour with it
Bitterly, the symptom such as weakness of limbs effect highly significant.
Specifically, the present invention provides one kind to treat cold Chinese medicine composition, by weight, by 5-15 parts of cassia twig, apricot
1-10 parts of 4-20 parts of benevolence, 1-10 parts of radix glycyrrhizae, 5-15 parts of Chinese ephedra, 5-15 parts of radix scrophulariae, levisticum compositions.
Further, the treatment cold Chinese medicine composition, by weight, by 8-12 parts of cassia twig, almond 9-15
3-7 parts of part, 3-7 parts of radix glycyrrhizae, 8-12 parts of Chinese ephedra, 8-12 parts of radix scrophulariae, levisticum compositions.
Yet further, the treatment cold Chinese medicine composition, by weight, by 10 parts of cassia twig, 12 parts of almond,
5 parts of 5 parts of radix glycyrrhizae, 10 parts of Chinese ephedra, 10 parts of radix scrophulariae, levisticum compositions.
Chinese medicine composition described above can directly be taken through water decoction filtering, can also be by pharmaceutically common
Various formulations are made with pharmaceutically acceptable pharmaceutic adjuvant after extracting method is extracted.
Present invention also offers a kind of preparation method for treating cold Chinese medicine composition, it is characterised in that：Including following step
Suddenly：
(1) take the cassia twig of formula ratio, almond, radix glycyrrhizae, Chinese ephedra to clean, cut into slices, add the 4-6 times of water measured, decoct 1-3h,
Filtering, filtrate concentration, is dried to obtain extract powder；
(2) step is taken to add 70-80% ethanol solution refluxing extractions, 40-60min, recycles ethanol, is concentrated and dried, obtains
Extract medicinal powder；
(3) step (1) extract powder is uniformly mixed with step (2) extraction medicinal powder, obtains traditional Chinese medicine extraction medicinal powder.
Preferably, above-mentioned steps (1) are that cassia twig, almond, radix glycyrrhizae, Chinese ephedra, radix scrophulariae, the levisticum for taking formula ratio are cleaned, and are cut
Piece, adds the water of 5 times of amounts, decocts 1-3h, filtering, filtrate concentration, is dried to obtain extract powder.
(2) described above are to take cassia twig, almond, radix glycyrrhizae, Chinese ephedra 75% ethanol solution refluxing extraction of addition, 50min,
Ethanol is recycled, is concentrated and dried, obtains extraction medicinal powder.
The upper Chinese medicine composition is preferably made capsule.
It is the starch that obtained traditional Chinese medicine extraction medicinal powder is added to 2 times of amounts, granulation, fills glue when Chinese medicine composition is made
Capsule, obtains capsule.
Beneficial effects of the present invention：
It is characteristic of the invention that formula is reasonable, without auxiliary material, curative effect height, not air-dispersing, do not influence work and life, nontoxic
Side effect, it is convenient to take.Through on probation, efficient up to 100%, the cure rate more than 95%, particularly for treatment of capsule of the present invention
Flu and it is caused it is dizzy, ache with it, the symptom effect highly significant such as weakness of limbs.
In order to make those of ordinary skill in the art be better understood from the present invention, the applicant has carried out a series of experiments and has ground
Study carefully, to prove the effect of the present invention：
1st, acute toxicity test：Healthy mice is taken separately to take 40 small white mouses to carry out formal test, experiment after carrying out trial test
It is preceding by animal fasting 16 it is small when, water restriction, dosage are not, 1000g (crude drug)/kg, observe 7 days, normal diet, drink
Water, observation index are animal dead number.As a result, the concentration single administration (mouse) is observed 7 days, none dead mouse.
2nd, successive administration toxicity test：Healthy mice 80 is taken, is randomly divided into 4 groups, investigational agent small dose group daily administration
1 time；Middle dose group is administered three times a day；Heavy dose of (100 times of adult human dose) are organized daily administration 6 times；Blank control group to etc.
The N.S of amount；Tested according to acute oral toxicity, investigational agent is small, in, heavy dose of group dosage be 3mg/g, successive administration 14
My god, normal diet drinking-water, continuous to observe, control group is same.Observation index is the weight of animals growth pattern, active situation, diet feelings
Condition, excrement situation and death condition.As a result, each group mouse, without intoxication conditions, activity, diet drinking-water, excrement situation are just
Often, none is dead, and body weights carry out statistical procedures with blank control group, and p value is all higher than 0.05, and there was no significant difference.Examination
Test and the results are shown in Table 3.
1 successive administration toxicity test result of table
Test Summary：Experiment shows that preparation of the present invention is nontoxic, and security is good.
2nd, clinical test of the invention：
The present invention was in Nanning City's outpatient service in 2016, and with screening, 60 are diagnosed as flu patient, its symptom is：Dizzy, body
On ache, weakness of limbs, be divided into 2 groups, every group of 30 people, test group takes capsule made of Chinese medicine composition of the present invention, daily
3 times, 3 tablets each time.Control group takes cold relief capsule made from patent No. CN201410520944.1 methods, after three days, investigates medicine
Imitate effect.
Table 2：The Effect tests situation of cold relief capsule produced by the present invention：
| Test group | Cure rate | It is efficient |
| Test group | 95% | 100% |
| Control group | 90% | 98% |
Above-mentioned experiment show cold Chinese medicine composition of the present invention be used for treat catch a cold effect it is very definite.
It is significantly better than control group.
Embodiment：
Embodiment 1：It is prepared by the capsule for the treatment of flu：
Formula：Cassia twig 5g, almond 4g, radix glycyrrhizae 1g, Chinese ephedra 5g, radix scrophulariae 5g, levisticum 1g；
(1) take the cassia twig of formula ratio, almond, radix glycyrrhizae, Chinese ephedra to clean, cut into slices, add the water of 4 times of amounts, decoct 1-3h, mistake
Filter, filtrate concentration, is dried to obtain extract powder；
(2) step is taken to add 70% ethanol solution refluxing extraction, 40min, recycles ethanol, is concentrated and dried, and obtains extraction medicine
Powder；
(3) step (1) extract powder is uniformly mixed with step (2) extraction medicinal powder, obtains traditional Chinese medicine extraction medicinal powder, add 2 times
The starch of amount, granulation is encapsulated, obtains capsule.
Embodiment 2：It is prepared by the capsule for the treatment of flu：
Formula：Cassia twig 8g, almond 9g, radix glycyrrhizae 3g, Chinese ephedra 8g, radix scrophulariae 8g, levisticum 3g；
(1) take the cassia twig of formula ratio, almond, radix glycyrrhizae, Chinese ephedra to clean, cut into slices, add the water of 5 times of amounts, decoct 1-3h, mistake
Filter, filtrate concentration, is dried to obtain extract powder；
(2) step is taken to add 75% ethanol solution refluxing extraction, 50min, recycles ethanol, is concentrated and dried, and obtains extraction medicine
Powder；
(3) step (1) extract powder is uniformly mixed with step (2) extraction medicinal powder, obtains traditional Chinese medicine extraction medicinal powder, add 2 times
The starch of amount, granulation is encapsulated, obtains capsule.
Embodiment 3：It is prepared by the capsule for the treatment of flu：
Formula：Cassia twig 10g, almond 12g, radix glycyrrhizae 5g, Chinese ephedra 10g, radix scrophulariae 10g, levisticum 5g；
(1) take the cassia twig of formula ratio, almond, radix glycyrrhizae, Chinese ephedra to clean, cut into slices, add the 4-6 times of water measured, decoct 1-3h,
Filtering, filtrate concentration, is dried to obtain extract powder；
(2) step is taken to add 70% ethanol solution refluxing extraction, 40min, recycles ethanol, is concentrated and dried, and obtains extraction medicine
Powder；
(3) step (1) extract powder is uniformly mixed with step (2) extraction medicinal powder, obtains traditional Chinese medicine extraction medicinal powder, add 2 times
The starch of amount, granulation is encapsulated, obtains capsule.
Embodiment 4：It is prepared by the capsule for the treatment of flu：
Formula：Cassia twig 12g, almond 15g, radix glycyrrhizae 7g, Chinese ephedra 12g, radix scrophulariae 12g, levisticum 7g.
(1) take the cassia twig of formula ratio, almond, radix glycyrrhizae, Chinese ephedra to clean, cut into slices, add the water of 6 times of amounts, decoct 3h, filtering,
Filtrate concentrates, and is dried to obtain extract powder；
(2) take step to add 80% ethanol solution refluxing extraction 60min, recycle ethanol, be concentrated and dried, obtain extraction medicine
Powder；
(3) step (1) extract powder is uniformly mixed with step (2) extraction medicinal powder, obtains traditional Chinese medicine extraction medicinal powder, add 2 times
The starch of amount, granulation is encapsulated, obtains capsule.
Embodiment 5：It is prepared by the capsule for the treatment of flu：
Formula：Cassia twig 15g, almond 20g, radix glycyrrhizae 10g, Chinese ephedra 15g, radix scrophulariae 15g, levisticum 10g.
(1) take the cassia twig of formula ratio, almond, radix glycyrrhizae, Chinese ephedra to clean, cut into slices, add the water of 6 times of amounts, decoct 1-3h, mistake
Filter, filtrate concentration, is dried to obtain extract powder；
(2) step is taken to add 80% ethanol solution refluxing extraction, 60min, recycles ethanol, is concentrated and dried, and obtains extraction medicine
Powder；
(3) step (1) extract powder is uniformly mixed with step (2) extraction medicinal powder, obtains traditional Chinese medicine extraction medicinal powder, add 2 times
The starch of amount, granulation is encapsulated, obtains capsule.
Claims (9)
1. one kind treats cold Chinese medicine composition, it is characterised in that：By weight, by 5-15 parts of cassia twig, 4-20 parts of almond, sweet
1-10 parts of 1-10 parts careless, 5-15 parts of Chinese ephedra, 5-15 parts of radix scrophulariae, levisticum compositions.
2. treatment cold Chinese medicine composition according to claim 1, it is characterised in that：By weight, by cassia twig 8-12
3-7 parts of part, 9-15 parts of almond, 3-7 parts of radix glycyrrhizae, 8-12 parts of Chinese ephedra, 8-12 parts of radix scrophulariae, levisticum compositions.
3. cold Chinese medicine composition is treated according to claim 1 or 2, it is characterised in that：By weight, by 10 parts of cassia twig, apricot
5 parts of 12 parts of benevolence, 5 parts of radix glycyrrhizae, 10 parts of Chinese ephedra, 10 parts of radix scrophulariae, levisticum compositions.
4. cold Chinese medicine composition is treated according to claim 1 or 2, it is characterised in that：Chinese medicine composition can be decocted through water
Filter is directly taken, can also by pharmaceutically common extracting method it is extracted after and pharmaceutically acceptable pharmaceutic adjuvant system
Into various formulations.
A kind of 5. preparation method for treating cold Chinese medicine composition, it is characterised in that：Comprise the following steps：
(1) take the cassia twig of formula ratio, almond, radix glycyrrhizae, Chinese ephedra to clean, cut into slices, add the 4-6 times of water measured, decoct 1-3h, filtering,
Filtrate concentrates, and is dried to obtain extract powder；
(2) step is taken to add 70-80% ethanol solution refluxing extractions, 40-60min, recycles ethanol, is concentrated and dried, is extracted
Medicinal powder；
(3) step (1) extract powder is uniformly mixed with step (2) extraction medicinal powder, obtains traditional Chinese medicine extraction medicinal powder.
6. the preparation method for the treatment of cold Chinese medicine composition according to claim 5, it is characterised in that：Step (1), which takes, matches somebody with somebody
Cassia twig, almond, radix glycyrrhizae, Chinese ephedra, radix scrophulariae, the levisticum just measured are cleaned, section, add the water of 5 times of amounts, decoct 1-3h, filtering, filtrate
Concentration, is dried to obtain extract powder.
7. the preparation method for the treatment of cold Chinese medicine composition according to claim 5, it is characterised in that：(2) are
Cassia twig, almond, radix glycyrrhizae, Chinese ephedra is taken to add 75% ethanol solution refluxing extraction, 50min, recycles ethanol, is concentrated and dried, is carried
Get it filled powder.
8. according to any treatment cold Chinese medicine compositions of claim 1-3, it is characterised in that：Chinese medicine composition is made
Capsule.
9. the preparation method for the treatment of cold Chinese medicine composition according to claim 8, it is characterised in that：Be will it is obtained in
Medicine extraction medicinal powder adds the starch of 1 times of amount, and granulation is encapsulated, obtains capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710762476.2A CN107982350A (en) | 2017-08-30 | 2017-08-30 | One kind treats cold Chinese medicine composition and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710762476.2A CN107982350A (en) | 2017-08-30 | 2017-08-30 | One kind treats cold Chinese medicine composition and preparation method thereof |
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| Publication Number | Publication Date |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6259219A (en) * | 1985-09-10 | 1987-03-14 | Ikeda Mohandou:Kk | Antitussive, expectorant, analgesic and sedative agent for external use |
| JPH06287144A (en) * | 1993-02-03 | 1994-10-11 | Takeda Chem Ind Ltd | Pharmaceutical preparation for common cold |
| CN104257798A (en) * | 2014-09-29 | 2015-01-07 | 洛阳御平国生物科技有限公司 | Traditional Chinese medicine formula for treating common cold |
| CN104971109A (en) * | 2015-07-27 | 2015-10-14 | 黄名珠 | Traditional Chinese medicine used for treating cold fever |
-
2017
- 2017-08-30 CN CN201710762476.2A patent/CN107982350A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6259219A (en) * | 1985-09-10 | 1987-03-14 | Ikeda Mohandou:Kk | Antitussive, expectorant, analgesic and sedative agent for external use |
| JPH06287144A (en) * | 1993-02-03 | 1994-10-11 | Takeda Chem Ind Ltd | Pharmaceutical preparation for common cold |
| CN104257798A (en) * | 2014-09-29 | 2015-01-07 | 洛阳御平国生物科技有限公司 | Traditional Chinese medicine formula for treating common cold |
| CN104971109A (en) * | 2015-07-27 | 2015-10-14 | 黄名珠 | Traditional Chinese medicine used for treating cold fever |
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Application publication date: 20180504 |