JPH06287144A - Pharmaceutical preparation for common cold - Google Patents

Abstract

PURPOSE:To provide a pharmaceutical preparation for common cold having broad drug effect and low side effect. CONSTITUTION:The pharmaceutical preparation for common cold is produced by compounding (A) one or more kinds of herb drugs having broad drug effect such as antipyretic action, analgesic action, antitussive action and antiinflammatory action and selected from SAIKO (root of Bupleurum falcatum), KAKKON (root of Pueraria lobata), SAISHIN (rhizome of Asiasarum sieboldi), ZENKO (root of Peucedanum praeruptorum) and SOYOU (leaf of Perilla frutescens) (especially preferably SAIKO) with (B) a non-herb drug such as antipyretic agent, analgesic agent, enzymatic agent, antihistaminic agent, adrenergic agent (decongestant and bronchial dilatory, antitussive agent and expectorant. A wider and stronger improving effect on common cold can be attained by the synergistic effect of the broad pharmacological action of the component A and the drug action of the component B.

Description

Detailed Description of the Invention

[0001]

The present invention relates to at least one synthetic active ingredient, namely an antipyretic analgesic, an antihistamine, an antitussive and / or an expectorant, a sympathomimetic (a decongestant and a bronchodilator) and an antipyretic and analgesic agent. It is selected from the following herbs that have a wide range of pharmacological actions such as action, antitussive action, anti-inflammatory action, such as Saiko (Saiko), Kakon (Kudzu root), Saishin (Spicy), Zenko (Pre-Hu), and Soyo (Su leaf). It relates to a composition for treating colds, which comprises one or more species.

[0002]

2. Description of the Related Art Generally, "cold" is the most common disease, and although everyone has at least one or two colds, It tends to be neglected, and it is said that there are many cases of secondary transition. Furthermore, it is said that "cold is the cause of all illnesses", and in many cases, it is repeatedly affected by carelessness in daily life and unhealth before it is completely cured.
Often associated with serious illness, how to treat this early is an important issue for today's medicine. There are several possible causes of cold syndrome, but
It is said that 90% is caused by virus, and there are few root treatment methods, and most of them are symptomatic treatments that treat each individual condition. Many people suffer from unpleasant cold symptoms, and there is a desire for a cold medicine that eliminates cold symptoms faster and more strongly. Antipyretics, analgesics, enzymes, antihistamines,
Antitussives / expectorants, sympathomimetics (decongestants, bronchodilators) and, if necessary, central stimulants (caffeines),
In order to prevent vitamins and gastric mucosal disorders, the amount of compounded ingredients such as antacids is increased and the amount of each ingredient is increased to treat cold syndrome. However, if the compounding amount is increased in anticipation of a high effect, there will be many problems in terms of side effects and the intended purpose will be lost. Therefore, today, there is a demand for a drug having a higher therapeutic effect and less side effects.

On the other hand, in China, it has been reported that Psycho (Saiko) is an extremely effective drug for febrile diseases such as common cold, epidemic cold, and hepatitis (Chuo Andai Dictionary). From these traditions and recent findings, the anti-inflammatory action, antipyretic action, analgesic action, sedative action, antitussive action and suppressive action against influenza virus of this drug have been confirmed. However, Psycho has been exclusively used as a compounding agent, and a cold drug formulation containing Psycho alone has not been known yet.

[0004]

[Means for Solving the Problems] In view of such circumstances, the present inventors have conducted earnest studies to obtain a cold medicine preparation having a broader medicinal effect and being safer. As a result, by combining various crude drugs and non-herbal drugs having multiple pharmacological actions, such as antipyretic, analgesic, antitussive, anti-inflammatory, and suppressive action against influenza virus, each of the multiple pharmacological actions possessed by the crude drug is Coupled with the medicinal effect of crude drug,
The present invention has been completed by further improving the effect on cold symptoms and finding that a drug having a higher effect and less side effects can be obtained. That is,
The present invention is a cold medicine prepared by blending one or more kinds of crude drug and non-crude drug selected from Psycho (Saiko), Cuckon (Kudzu root), Saishin (Spicy spice), Zenko (Senior Hu) and Soyo (Su leaf). Regarding the formulation. The above crude drugs may be used in combination of two or more kinds, or may be used alone. As a non-crude drug which is effective in treating cold symptoms and used in combination with at least one of the above crude drugs (that is, a medicinal component obtained by chemical synthesis, fermentation method or a combination thereof), antipyretic agent, analgesic agent, enzyme agent, antihistamine agent, antitussive agent , Expectorants, sympathomimetics (decongestants, bronchodilators) and the like, and it is preferable to use one or more of them. Furthermore, if necessary, caffeine (central stimulant) such as anhydrous caffeine, vitamins (eg, vitamin B ₁ , vitamin B ₂ , vitamin C), antacids [eg, cumulite (aluminum hydroxide,
Coprecipitation product of sodium hydrogen carbonate), aluminum hydroxide, calcium carbonate, noicillin (magnesium aluminometasilicate), synthetic hydrotalcite, sanalmine], other herbal medicines (Timo, Hamabofu, Dokukatsu), etc. You may mix according to the cold medicine standard of a manufacturing guideline.

Among the herbal medicines in the present invention, preferably psycho (saiko), psycho extract or psycho extract powder. Psycho (saiko) is said to have a very characteristic action since ancient times. For example, it removes gastrointestinal discomfort, dyspepsia, and cold and cold, and restores vitality. Get rid of fever and hot sputum to eliminate chest pain. (Homokusa) Mainly on the heart and belly, removes cold and cold, removes troubles, stops surprises, eliminates sputum, and stops coughing. (Palaceic medicine counseling) Mainly cures chest chest complaints, and also treats cold fever, abdominal pain, and jaundice. (Pharmacophyllum) Saiko is one of the surface treatment drugs, which has the effects of opening depression through the liver, reconciling both sides, rejecting fever, and raising the sun (Introduction to Chinese medicine). As stated above, Psycho (saiko) is considered to be a herbal medicine that exhibits its efficacy as the cold changes from the acute phase to the chronic phase.

Psycho (saiko) used in the present invention
May be blended in the form of powder, extract, or extract powder. The blending amount is 100 for the adult daily dose.
~ 3000 mg, preferably 200-2000 mg.
When a dry extract is used, it depends on the extract extraction solvent, but for example, dilute ethanol extract (extract yield 15%
As for), the daily dose for adults is 15 to 450 mg, preferably 30 to 300 mg. In addition, since it is the extract powder that is easy to handle in formulation, the psycho-extract is directly spray-dried to form an extract powder, and an adsorbent commonly used in the pharmaceutical industry, such as Syloid (trade name; Silicic acid anhydride), lactose, starch, crystalline cellulose, E
Excipient powder may be obtained by adding an excipient such as CG505 (trade name: carmellose calcium) and additives, and obtaining an extract powder by a wet granulation method, a spray drying method (spray drying) or the like. The adult daily dose of the extract powder is used by converting it into the dry extract amount.
For the production of the extract, roots such as Mishima Psycho are chopped and extracted using water or a lower alcohol (methyl alcohol, ethyl alcohol, isopropyl alcohol, etc.) and a hydrophilic organic solvent (acetone, acetonitrile, etc.) as a solvent,
A soft extract is obtained by filtration and concentration by a method generally used in the pharmaceutical industry.

[0007] Usually, dried roots of leguminous leguminous roots are used as cuckons. It may be in the form of powder, extract, or extract powder. These can be manufactured by the same method as the above psycho method. The adult content of the parentheses is 1
If the end of daily dose is 7,000-10,000mg,
In the case of dry extract, dilute ethanol extract 700-1.0
00 mg (assuming an extract yield of 10%), in the case of extract powder,
It is 700 to 1,000 mg as a dry extract equivalent amount.
As the cabbage (spicy), dried rhizomes and roots of the cabbage sinensis family are usually used. Powder, extract,
Extract powder may be in any form. These can be obtained in the same manner as the above psycho. The blending amount is 2,000 to 3,000 mg for the adult daily dose, 300 to 450 mg of dilute ethanol extract (as an extract yield of 15%) for the dry extract, and dry extract for the extract powder. The converted amount is 300 to 450 mg.

As Zenko (pre-hus), dried roots of white-flowered pre-hus in the Apiaceae are usually used. It may be used in the form of powder, extract, or extract powder. These can be produced in the same manner as the above-mentioned Psycho powder, extract, and extract powder. The daily dose for adults is 1,500-3,000 mg in the case of powder, and diluted ethanol extract (as an extract yield of 15%) in the case of dry extract 230-
In the case of 450 mg, extract powder, it is converted to dry extract and 2
It is 30 to 450 mg. As the soybean (so leaves), the above-mentioned perilla of the Labiatae family is usually dried and used, but the leaf part of Chili Menjiso is preferably used. The powder may be used in the form of powder, extract, or extract powder, and the manufacturing method of each is in accordance with Psycho. In the case of adult, the daily dose is 1.00
0 to 2,000 mg, in the case of dry extract, 250 to 500 mg of dilute ethyl alcohol (as an extract yield of 25%), and in the case of extract powder, it is 250 to 500 in terms of dry extract.
mg.

The non-herbicide synthetic drugs include antipyretics, analgesics, antihistamines, antitussives, expectorants, sympathomimetics (decongestants, bronchodilators) or acceptable salts thereof. As antipyretics and analgesics, nonsteroidal anti-inflammatory agents are preferable, and examples thereof include aspirin, aspirin aluminum, acetaminophen, etenzamid, salicylamide, lactylphenetidine, salicylic acid, isopropylantipyrine, ibuprofen, phenacetin, mefenamic acid, flufenamic acid, flufenum. Aluminum acid, choline salicylate, diflunisal,
Sulpirin, alclofenac, fenbufen, diclofenac sodium, ketoprofen, naproxen, fenoprofen calcium, pranoprofen,
Tinolidine hydrochloride, epirizole, tiaramid hydrochloride, acetamethacin, tolmetin sodium, piroxicam, fenthiazac, thiaprofenic acid, sazapyrine, sodium salicylate are preferred, and among these, aspirin, aspirin aluminum, acetaminophen, ethenzamide, salicylamide, lactylphenetidine,
Isopropylantipyrine, ibuprofen, sazapyrine, sodium salicylate are preferred. The amount of the antipyretic agent and the analgesic is determined according to the types and amounts of the other drugs used in combination according to known formulation methods, but the dose per adult is preferably 50 to 4000 mg, more preferably 200 to 1000 mg. A certain amount is preferable.
As the enzyme agent, for example, serrapeptase, lysozyme chloride, bromelain, seaprose S, pronase are preferable. Especially, serrapeptase and lysozyme chloride are preferable. Enzyme preparations are usually administered in adult doses of 1.3-
It is advisable to add it in an amount of 180 mg, preferably 5 to 20 mg.

Antihistamines include isothipendyl hydrochloride,
Diphenylpyraline hydrochloride, diphenhydramine hydrochloride, difeterol hydrochloride, triprolidine hydrochloride, triperenamine hydrochloride, tonzylamine hydrochloride, phenetazine hydrochloride, metzirazine hydrochloride, diphenhydramine salicylate, diphenyldisulfonic acid carbinoxamine, alimemazine tartrate, tannic acid diphenhydramine, hydromethacyl dihydropyranylate, dimethylacyl naphthalic acid, diphenylpyranyl telocurate, tenocuric acid Preferred compounds include promethazine methylene disalicylate, carbinoxamine maleate, dl-chlorpheniramine maleate, d-chlorpheniramine maleate, difeterol phosphate, promethazine, mequitazine, cyproheptadine hydrochloride, iproheptine hydrochloride, and clemastine fumarate. Furthermore, among these, isothipendyl hydrochloride, diphenylpyraline hydrochloride, diphenhydramine hydrochloride, difeterol hydrochloride, triprolidine hydrochloride, triperenamine hydrochloride, tonzylamine hydrochloride, phenetazine hydrochloride, metzirazine hydrochloride, diphenhydramine salicylate, carbinoxamine diphenyldisulfonate, diphenhydramine tannate tannate, and tarfenate diphenhydramine tannate. Particularly preferred are diphenylpyraline, mebuhydroline napadisylate, promethazine methylene disalicylate, carbinoxamine maleate, dl-chlorpheniramine maleate, d-chlorpheniramine maleate and difeterol phosphate. The compounding amount of these antihistamines is usually selected from the compounding amount so that the dose per adult is 0.3 to 300 mg, preferably 1 to 50 mg.

Among the antitussives, preferred compounds are, for example, alloclamide hydrochloride, cloperastine hydrochloride, carbetapentane citrate, tipepidine citrate, sodium dibnate, dextromethorphan hydrobromide, dextromethorphan / phenolphthaline salt, hibenz. Acid tipepidine, cloperastine fendizoate, codeine phosphate, dihydrocodeine phosphate, dimemorphan phosphate, pentoxyberine citrate, benproperine phosphate, isoaminyl citrate, oxelazine citrate, oxeradine tannate, epradinone hydrochloride, clobutynol hydrochloride, clofbutin hydrochloride Danol, hominoben hydrochloride, noscapine hydrochloride, noscapine, dl-methylephedrine hydrochloride, dl-methylephedrine saccharin salt, l-methylephedrine hydrochloride, hydrochloric acid Rimetokinoru, phenylpropanolamine hydrochloride, include hydrochloric methoxyphenamine. In particular, alloclamide hydrochloride, cloperastine hydrochloride, carbetapentane citrate, tipepidine citrate,
Sodium dibunate, dextromethorphan hydrobromide, dextromethorphan / phenolphthalinate, tipepidine hibenzate, cloperastine fendizoate, codeine phosphate, dihydrocodeine phosphate, noscapine hydrochloride, noscapine, dl-methylephedrine hydrochloride,
Dl-methylephedrine saccharin salt, l-methylephedrine hydrochloride, trimethoquinol hydrochloride, phenylpropanolamine hydrochloride, and methoxyphenamine hydrochloride are preferred. The preferred amount of the antitussive agent is usually 0.5 to 160 mg per adult, more preferably 2 to 50 m.
It is recommended that the compounding amount be adjusted to g.

Preferred expectorants are tipepidine citrate, tipepidine hibenzate, dl-methylephedrine hydrochloride, dl-methylephedrine saccharin salt, potassium guaiacolsulfonate, guaifenesin, epradinone hydrochloride, acetylcysteine, l-ethylcysteine hydrochloride, L-methylcysteine hydrochloride, carbocysteine, bromhexine hydrochloride, ambroxol hydrochloride, trimethoquinol hydrochloride, phenylpropanolamine hydrochloride,
Methoxyphenamine hydrochloride, l-methylephedrine hydrochloride, aminophylline, theophylline, diprophylline,
Proxyphylline, ammonium chloride, potassium cresol sulfonate, among these, tipepidine citrate, tipepidine hibenzate, dl-methylephedrine hydrochloride, dl-methylephedrine saccharin salt, potassium guaiacolsulfonate, guaifenesin, l-ethylcysteine hydrochloride , L-methylcysteine hydrochloride,
Bromhexine hydrochloride, Trimethoquinol hydrochloride, Phenylpropanolamine hydrochloride, Methoxyphenamine hydrochloride, l
-Methylephedrine hydrochloride, aminophylline, theophylline, diprophylline, proxyphylline, ammonium chloride, potassium cresol sulfonate are preferred.
In addition, expectorant is usually 0.5 to 0.5 per adult.
It is preferable to add 1000 mg, more preferably 2 to 300 mg.

Preferred compounds of the sympathomimetic agents (decongestants, bronchodilators) are ephedrine hydrochloride,
dl-methylephedrine hydrochloride, phenylpropanolamine hydrochloride, phenylephrine, l-methylephedrine hydrochloride, dl-methylephedrine saccharin salt, methoxyphenamine hydrochloride, dl-epinephrine hydrochloride, dl-isoproterenol hydrochloride, isoproterenol sulfate, orciprenaline sulfate. , Terbutaline sulfate, salbutamol sulfate, trimethoquinol hydrochloride, hexoprenaline sulfate, chlorprenaline hydrochloride, tulobuterol hydrochloride, procaterol hydrochloride, pirbuterol hydrochloride, fenoterol hydrobromide,
Includes formoterol fumarate, clenbuterol hydrochloride, mabuterol hydrochloride, ethyl cysteine hydrochloride, methyl cysteine hydrochloride. Particularly preferred are dl-methylephedrine hydrochloride, phenylpropanolamine hydrochloride, l-methylephedrine hydrochloride, dl-methylephedrine saccharin salt, methoxyphenamine hydrochloride, trimethoquinol hydrochloride, ethyl cysteine and methyl cysteine hydrochloride. The sympathomimetic agent is preferably added so that the dose per adult is 0.5 to 200 mg, more preferably 2 to 50 mg.

The composition of the present invention can be exemplified as oral administration solid preparations such as tablets, granules and capsules and preparation forms such as liquid preparations. These formulations can be prepared by a conventional method. In addition, at the time of formulation, if necessary, grouping may be performed to stabilize the active ingredient. The term "grouped compounding" as used herein means a method in which ingredients having poor mixability are separately made into granules and then mixed to reduce the contact area of the ingredients to stabilize the composition, or granules separately made into groups. Using a layered tablet machine (manufactured by Kikusui Seisakusho, etc.) to form a two-layer tablet, and further a thin buffer layer provided between the two layers to form a sandwich-type tablet. It is a composition which is stabilized by being separated by a method such as coating with or encapsulating in a microcapsule. In preparing the formulation, commonly used fillers, fillers, binders, moisturizers, disintegrants, surfactants, lubricants, diluents and excipients can be used. Other solubilizers, buffers, preservatives, fragrances, coloring agents, flavoring agents and the like can be used if necessary.

As the cold medicine preparation, more specifically, as an excipient, lactose, corn starch, mannitol, crystalline cellulose, sucrose, etc., and as a binder, hydroxypropylcellulose, hydroxypropylmethylcellulose, polyvinylpyrrolidone, methylcellulose, α Carmelose calcium [ECG50
5 (trade name)], croscarmellose sodium [Acdisol (trade name)], cross-linked polyvinylpyrrolidone [crospovidone (trade name)] and the like, and magnesium stearate, talc and the like as a lubricant are preferably blended. The preparation of the present invention can also be used as a coated tablet. The coating can be performed by a known method. As the coating agent, a commonly used coating agent (for example, hydroxypropylmethylcellulose, hydroxypropylcellulose (hereinafter referred to as HPC), methylcellulose, polyvinylpyrrolidone, etc.) is used. In coating, a coating aid may be used by a conventional method, and as such a coating aid, pigments such as polyethylene glycol 6000, polysorbate (eg, Tween 80, etc.), titanium oxide, red iron oxide and the like are used.

[0016]

INDUSTRIAL APPLICABILITY The thus obtained cold medicine preparation of the present invention has a broader and larger effect on cold symptoms by combining the broad pharmacological action of crude drugs and the efficacy of non-crude drugs. In addition, a cold medicine preparation with less side effects is obtained.

[0017]

EXAMPLES Examples and test examples of formulation of the present invention will be specifically described below, but the present invention is not limited to the following examples. Example 1 According to the following prescription, a cold medicine containing psychotic powder of the present invention and a control medicine containing no psychotic powder are prepared as tablets according to the Japanese Pharmacopoeia, 15 tablets of the general rule of formulation from each component, and cold symptoms are complained. The effects of the patients were compared (the former administration group is group B and the latter administration group is group P). 1) Test drug prescription: Adult daily dose <The cold medicine of the present invention><Controldrug> (Administered to group B) (Administered to group P) Acetaminophen 900 mg 900 mg Dihydrocodeine phosphate 24 mg 24 mg Noscapine 48 mg 48 mg Methylephedrine hydrochloride 60 mg 60mg Chlorpheniramine maleate 7.5mg 7.5mg Anhydrous caffeine 75mg 75mg Psycho powder 600mg-

2) Test method A daily dose of the above-mentioned drug was administered to 28 adult male and female B groups and 21 P groups who complained of various symptoms of a cold, and the symptoms were improved for 1, 3, 5 hours and 2 Surveys were conducted on the 3rd, 4th, and 5th days (final judgment date). 3) Results The results are shown in [Fig. 1] to [Fig. 6]. Each graph shows the improvement rate in the table. In the final judgment, body pain [Fig. 1] and cough [Fig. 5] clearly show that the cold-medicated cold-medication preparation of the present invention (Group B) is a non-psychoactive control drug (P).
Group), and also in general malaise [Fig. 2] and headache [Fig. 4], the cold remedy of the present invention (Group B) had a better symptom improvement rate. As a result, it was revealed that the combination of Psycho (Saiko) contributed to the improvement of cold symptoms.

Example 2 Fine particles of a psychoextract group (S group) were prepared according to the following formulation using a spray dryer, while a group containing phenylpropanolamine hydrochloride (A group) of the following formulation was mixed using a mixer. An HPC aqueous solution was used as a binder, kneaded, dried and sized to give granules. After separately preparing the S group and the P group in this way, crystalline cellulose, acdizol (trade name; croscarmellose sodium), and magnesium stearate were added to both groups and mixed, and a tablet machine (Kikusui Seisakusho Correct 19K)
At a weight of 267 mg and a pressure of 2 ton / cm using an 8.5 mmφ punch.
Tableted at ² . In this example, the compounds were grouped and blended in order to stabilize phenylpropanolamine hydrochloride. Prescription: Adult daily dose (out of 9 tablets) Group A Acetaminophen 900 mg Dihydrocodeine phosphate 24 mg Chlorpheniramine maleate 7.5 mg Phenylpropanolamine hydrochloride 75 mg Anhydrous caffeine 75 mg S group Dry psycho extract 240 mg (1600 mg as the active drug) ) Cumulite 180mg

Example 3 The same procedure as in Example 2 was repeated except that 120 mg of dried psychoextract was used instead of 240 mg of dried psychoextract in the formulation of Example 2,
A cold medicine tablet containing psychoextract was obtained by grouping and mixing for stabilization of phenylpropanolamine hydrochloride. Prescription: Adult daily dose (in 9 tablets) Group A Acetaminophen 900 mg Dihydrocodeine phosphate 24 mg Chlorpheniramine maleate 7.5 mg Phenylpropanolamine hydrochloride 75 mg Anhydrous caffeine 75 mg Group S dried psycho extract 120 mg (800 mg as the active drug) ) Cumulite 180mg

Example 4 Three kinds of cold remedies having different amounts of psychoextract blended according to the following prescription, namely, a cold remedy with a high dose of psychoextract prepared in Example 2 (compound 240 mg of psychoextract), Example 3
A cold medicine containing a low dose of psychoextract obtained in (1) (combined with 120mg of psychoextract) and 3 kinds of cold medicines not including psychoextract according to Example 2 for patients suffering from cold symptoms. Combined cold drug administration group H group, low dose 120 mg combined cold drug administration group L group,
A control cold-medication-administered group not containing psycho-extract was used as a group P, and each cold-medication was administered, and the effects were compared by a double-blind method. 1) Test drug prescription: Adult daily dose (in 9 tablets) H group L group P group acetaminophen 900 mg 900 mg 900 mg dihydrocodeine phosphate 24 mg 24 mg 24 mg dl-chlorpheniramine maleate 7.5 mg 7.5 mg 7.5 mg Phenylpropanolamine hydrochloride 75 mg 75 mg 75 mg Anhydrous caffeine 75 mg 75 mg 75 mg Cumulite 180 mg 180 mg 180 mg Dry psycho extract 240 mg 120 mg -2) Test method Adult males and females H group 67 persons, L group 66
, 61 patients in the P group were treated with the above-mentioned drug in a daily dose, and improvement of symptoms was investigated after 1, 3, 5 hours, 2 days, and 3 days. 3) Results The results of the surveys after 1, 3, 5 hours, 2 days, and 3 days are shown in FIGS. 7 to 11 as 1H, 3H, 5H, 2D, and 3D, respectively. Each graph shows the improvement rate in the table. In addition, the numbers in parentheses in the table indicate the number of target patients having each symptom. As a result, after 3 hours due to stuffy nose (FIG. 7), the improvement rate of the H group showed a significant improvement tendency (P <0.1) with respect to the P group. Cough [Fig. 8]: H group is 3
After a lapse of time, it showed an improvement tendency (P <0.1) with respect to the P group,
A significant difference was observed between the L group and the P group after 5 hours and 2 days (P <0.05). In case of tan [Fig. 9], H group, L
The group showed an excellent improving effect on the P group after 5 hours and after a few days. Also, after 3 hours of chills (FIG. 10), the H group showed an improvement tendency (P <0.1) with respect to the P group.
In fever (FIG. 11), after 3 and 5 hours, the H group and the L group showed an excellent improving effect with respect to the P group. The above significant difference analysis was performed by the χ ² test. From the above results, the combination of the psychoextract group (group S) and the group containing phenylpropanolamine hydrochloride (group A) obtained in Examples 2 and 3 contributes to the early improvement of cold symptoms in particular. It has been found.

[Brief description of drawings]

FIG. 1 shows the results of improving the symptoms of physical pain in group B administered with the cold medicine preparation containing psychotic powder of the present invention obtained in Example 1 and group P administered with the control medicine preparation containing no psychotic powder. Show.

FIG. 2 shows the results of improvement in general malaise symptoms of group B administered with the cold medicine preparation containing psychotic powder of the present invention obtained in Example 1 and group P administered with the control medicine preparation containing no psychological powder. .

FIG. 3 shows the results of improvement of fever symptoms in group B administered with the cold medicine preparation containing psychological powder of the present invention obtained in Example 1 and group P administered with the control medicine preparation containing no psychological powder.

FIG. 4 shows the results of improvement in sore throat of group B administered with the cold medicine preparation containing psychotic powder of the present invention obtained in Example 1 and group P administered with the control medicine preparation containing no psychotic powder. .

FIG. 5 shows the results of improvement of cough symptoms in the group B administered with the cold medicine preparation containing psychological powder of the present invention obtained in Example 1 and the group P administered with the control medicine preparation containing no psychological powder.

FIG. 6 shows the results of improvement in headache symptoms in group B administered with the cold medicine preparation containing psychological powder of the present invention obtained in Example 1 and group P administered with the control medicine preparation containing no psychological powder.

FIG. 7 shows the effect of improving the symptoms of nasal congestion in each group of Example 4.

FIG. 8 shows the effect of improving coughing symptoms in each group of Example 4.

FIG. 9 shows the effect of improving the symptoms of sputum in each group of Example 4.

FIG. 10 shows the effect of improving chills symptoms of each group of Example 4.

FIG. 11 shows the effect of improving fever symptoms in each group of Example 4.

[Explanation of symbols]

In FIGS. 7 to 11, H, L, and
P indicates the results of H group, L group, and P group, respectively. 7], [FIG. 8], and [FIG. 10], Δ in each graph has a tendency difference with respect to the P group (P <0.1), and in FIG. * Indicates that there is a significant difference with respect to the P group (P <0.05).

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁵ Identification code Internal reference number FI Technical indication location A61K 45/00 AA H 8415-4C AAU 8415-4C ABE 8415-4C ACF 8415-4C ACG 8415-4C ACH 8415-4C AEM 8415-4C // (A61K 35/78 45:00)

Claims (9)

[Claims] 1. A mixture of one or more crude drugs and non-crude drugs selected from Psycho (Saiko), Cuckon (Kudzu root), Saishin (Spicy spice), Zenko (Pre-Hu) and Soyo (Su leaf). Cold medicine formulation. 2. The cold medicine preparation according to claim 1, wherein the crude drug is Psycho. 3. A non-crude drug is an antipyretic drug, an analgesic drug, an enzyme drug,
The cold medicine preparation according to claim 1, which is an antihistamine, a sympathomimetic, a cough suppressant or an expectorant. 4. An antipyretic agent and an analgesic agent are aspirin, aspirin aluminum, acetaminophen, etenzamid,
The cold medicine preparation according to claim 3, which is salicylamide, lactylphenetidine, isopropylantipyrine, ibuprofen, sazapyrine or sodium salicylate. 5. The cold medicine preparation according to claim 3, wherein the enzyme agent is serrapeptase or lysozyme chloride. 6. The antihistaminic agent is isothipendyl hydrochloride, diphenylpyraline hydrochloride, diphenhydramine hydrochloride, difeterol hydrochloride, triprolidine hydrochloride, tripelenamine hydrochloride, tonzylamine hydrochloride, phenetazine hydrochloride, metzirazine hydrochloride, diphendihydramine salicylate, carbinoxamine diphenyldisulfonate tarimate tannin tartrate, and tarimetamine tartrate. The cold medicine preparation according to claim 3, which is, diphenylpyraline theoclate, mebhydroline napadisylate, promethazine methylene disalicylate, carbinoxamine maleate, dl-chlorpheniramine maleate, d-chlorpheniramine maleate, or difeterol phosphate. 7. A sympathomimetic agent is dl-methylephedrine hydrochloride, phenylpropanolamine hydrochloride, l-methylephedrine hydrochloride, dl-methylephedrine saccharin salt, methoxyphenamine hydrochloride, trimethoquinol hydrochloride,
The cold medicine preparation according to claim 3, which is ethyl cysteine hydrochloride or methyl cysteine hydrochloride. 8. An antitussive agent is alloclamide hydrochloride, cloperastine hydrochloride, carbetapentane citrate, tipepidine citrate, sodium dibnate, dextromethorphan hydrobromide, dextromethorphan / phenolphthaline salt, tipepidine hibenzate, phendizoic acid. Cloperastine, codeine phosphate, dihydrocodeine phosphate, noscapine hydrochloride, noscapine, dl-methylephedrine hydrochloride, dl-methylephedrine saccharin salt, l-methylephedrine hydrochloride, trimethoquinol hydrochloride, phenylpropanolamine hydrochloride or methoxyphenamine hydrochloride. The cold medicine preparation according to claim 3. 9. An expectorant is tipepidine citrate, tipepidine hibenzate, dl-methylephedrine hydrochloride, dl-methylephedrine saccharin salt, potassium guaiacolsulfonate, guaifenesin, L-ethylcysteine hydrochloride, L-methylcysteine hydrochloride, bromhexine hydrochloride. ，
The cold medicine preparation according to claim 3, which is trimethoquinol hydrochloride, phenylpropanolamine hydrochloride, methoxyphenamine hydrochloride, l-methylephedrine hydrochloride, aminophylline, theophylline, diprophylline, proxyphylline, ammonium chloride or potassium cresolsulfonate.