CN1951464A - Compound Chinese medicinal preparation for treating gynecological inflammation and preparation method thereof - Google Patents
Compound Chinese medicinal preparation for treating gynecological inflammation and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese pharmaceutical composition for treating gynaecologic inflammation, process for preparation, the use and main pharmacodynamic research result, wherein the formula of the medicament includes Leontopodium leontopodioides 30-500g, yellow corktree bark 15-300g, ash bark 25-450g, shiny pricklyash 30-400g, red peony root 20-300g, and nutgrass flatsedge rhizome 1-200g.
Description
Technical field
The present invention relates to a kind of pharmaceutical preparation that is used for gynecopathy therapeutic, relate to a kind of Chinese traditional compound medicine that the evil stasis of blood of damp and hot poison is forged the chronic pelvic inflammatory disease of burnt syndrome, bacterial vaginitis treatment that is used for specifically.
Background technology
Pelvic inflammatory disease is the gynaecopathia usually seen of chronic pelvic inflammatory disease right and wrong especially, and its sickness rate is the trend that increases gradually in recent years.In China, because the restriction of Personal hygiene condition and medical condition, or sterile working's idea is indifferent in gynecological's minor operation and family planning operation, and the patient does not note reasons such as Personal hygiene during the extensive use intrauterine device in addition, makes the sickness rate of pelvic inflammatory disease very high.Frequent day by day along with foreign exchanges, sexually transmitted disease (STD) is the trend that raises year by year at the sickness rate of China, and therefore the pelvic inflammatory disease that causes is also increasing.This situation is thin in sex consciousness, and sexual life is chaotic so that area that sexually transmitted disease (STD) is occurred frequently is more obvious.Chronic pelvic inflammatory disease is often failed thoroughly treatment for acute pelvic inflammatory disease in addition, or due to the weak course of disease delay of plain body, and what have is secondary to more serious chronic cervicitis, vaginitis.Clinical manifestation is with hypogastralgia repeatedly, and lumbosacral aching pain, leucorrhoea grow in quantity etc. are main, symptom such as often tired with menoxenia, low grade fever, susceptible, pelvic lump, sexual anhedonia.It is long to have the course of disease, and the state of an illness is touching, characteristics such as relapse rate height.According to the clinical manifestation of primary disease, chronic pelvic inflammatory disease belongs to the traditional Chinese medical science " lower abdominal pain ", " leukorrheal diseases ", " menoxenia ", “ mass in the abdomen " etc. category.According to the clinical research report, modern medicine does not have definite curative effect as yet for the treatment of chronic pelvic inflammatory disease at present, and the dialectical advantage in conjunction with differential diagnosis of diseases of modern TCM makes the traditional Chinese medical science in the treatment for the research chronic pelvic inflammatory disease certain progress be arranged.And bacterial vaginosis is the commonly encountered diseases in the department of obstetrics and gynecology outpatient service, and sickness rate is higher, and main clinic symptoms is a leucorrhoea grow in quantity, and pudendal pruritus brings very big inconvenience for patient's life.No specificity medication before its treatment, therapeutic effect is not obvious.Present situation based on present integrative therapy chronic pelvic inflammatory disease and bacterial vaginitis, our seminar is according to year clinical experience surplus 20, think that mostly the generation of primary disease is owing in deficiency of qi and blood such as capable puerperal, damp and hot malicious heresy goes into uterus and blood is tied the retardance vessels of the uterus mutually, and it is not smooth to cause the vessels of the uterus QI-blood circulation, stops up in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, causes the card of the evil stasis of blood knot of damp and hot poison, treatment is worked as with heat-clearing and toxic substances removing dampness, and blood-activating analgetic is a method.
Summary of the invention
The objective of the invention is to develop a kind of medicine for the treatment of gynaecopathia effectively, comprising composition, preparation method, purposes and the pharmacodynamic study result of medicine.
Advantage of the present invention is: this product is pure compound Chinese medicinal preparation, on the basis of comprehensive multiple treatment medicine for gynecopathy that square Chinese medicine is organic, dialectical ground compatibility together, Leontopodium leontopodioides (Willd.) Beauv. bitter cold in the side, heat-clearing and toxic substances removing removing heat from blood dampness removing is monarch, minister is with Cortex Phellodendri, Cortex Fraxini heat clearing and damp drying pathogenic fire detoxifcation leukorrhagia stopping, the effect of principal drug assistance performance damp eliminating pyrolysis fire-toxin, assistant is with Radix Paeoniae Rubra, Radix Zanthoxyli blood-activating analgetic, and QI and blood regulating gets freely mechanism of qi, blood stasis must be capable, damp and hot clearly, make with the Rhizoma Cyperi priming and return liver, make wind wood not inaccessible in ground, then in the sky, be good for and be with from disappearing by temper from ascension for ground vapour.All medicines share and make that damp and hot poison is evil must to be removed, QI-blood circulation gets freely, and all disease rehabilitations of the female section of woman are so the burnt syndrome of chronic pelvic inflammatory disease, bacterial vaginitis treatment this product is forged to(for) the evil stasis of blood of damp and hot poison have unique curative effect, its pharmacodynamics and toxicity research result show that also toxic and side effects is little, take safe and effective.
The objective of the invention is to realize by following measure:
1, a kind of compound Chinese medicinal preparation that is used for the treatment of gynaecopathia, the pharmaceutical preparation of forming by following Chinese medicinal raw materials in proportion by weight:
Leontopodium leontopodioides (Willd.) Beauv. (Leontopodium leontopdioides (wils) Beauv.) 30-500g
Cortex Phellodendri (cortex phellodendri amurensis) 15-300g
Cortex Fraxini (cortex fraxini) 25-450g
Radix Zanthoxyli (radix zanthoxyli) 30-400g
Radix Paeoniae Rubra (radix paeoniae rubra) 20-300g
Rhizoma Cyperi (rhizoma cyperi) 1-200g
2, the preferred proportion of compound Chinese medicinal preparation is (latin name is slightly):
Leontopodium leontopodioides (Willd.) Beauv. 345g Cortex Phellodendri 215g Cortex Fraxini 360g
Radix Zanthoxyli 295g Radix Paeoniae Rubra 260g Rhizoma Cyperi 105g
3, preparation method:
Six-element in the side, Rhizoma Cyperi is ground into fine powder, and is standby.Cortex Phellodendri, Cortex Fraxini, Radix Zanthoxyli are ground into coarse powder, add 6 times of amount 70% ethanol extractions 2 times, and each 3 hours, merge extractive liquid, filtered, and filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.30～1.35 (60 ℃), and is standby.All the other Leontopodium leontopodioides (Willd.) Beauv., Radix Paeoniae Rubra two flavors add 10 times of water gagings and decoct 2 times, and each 2 hours, collecting decoction, filter, filtrate decompression is concentrated into the thick paste that relative density is 1.30～1.35 (60 ℃), adds above-mentioned fine powder and thick paste, mixing, drying is pulverized, add appropriate amount of starch, mixing is with 95% ethanol system granule, dry, granulate is made solid preparation, promptly.
4, Pharmacodynamic test of active extract
4.1 the influence of rat paw edema due to the on Carrageenan
Get 50 of rats, raise after 2 days, be divided into five groups at random, 10 every group.Press the gastric infusion of dosage shown in the table 1, once a day, continuous three days, 1h after the last administration, 1% carrageenin (0.1ml/ only) injected under the right back sufficient plantar aponeurosis of rat successively cause inflammation, measured rat paw and ankle joint circumference every 1 hour with self-control arrowband chi, compare with left back foot, with about the sufficient sole of the foot and ankle joint circumference and difference be the swelling degree.The results are shown in Table 1.
The influence of rat paw edema due to table 1 this product on Carrageenan
| Group | G crude drug/kg | Number of animals n | Normally | Different time (h) foot swelling degree (mm behind the injection carrageenin; X ± SD) | ||||
| 1 | 3 | 4 | 5 | |||||
| Matched group FUYANKANG PIAN this product capsule this product capsule this product capsule | - 2.43g/kg 14.52 7.26 3.63 | 10 10 10 10 10 | 40.8±2.08 41.05±1.69 40.65±1.53 41.10±1.15 42.00±1.68 | 3.30±0.86 4.35±1.27* 4.35±1.31* 2.45±0.83** 2.55±1.12 | 5.40±1.43 3995±1.44* 3.85±1.75* 4.40±1.43 4.35±1.13*** | 8.80±1.09 6.75±2.70* 6.4O±2.22** 7.10±2.73 7.35±2.07** | 10.65±0.85 9.80±1.03* * 8.45±2.54* 8.65±3.26 9.55±1.66* * | 9.75±3.68 7.25±2.45** 7.25±2.15 7.50±3.11 7.40±2.16** |
*＜0.05，**p＜0.01，***p＜0.001
The result shows, behind the injection carrageenin, each dosage group of this product all demonstrates has in various degree inhibitory action to rat paw edema, remarkable with the matched group comparing difference.
4.2 xylol causes the influence of mice auricle swelling
Get 50 of mices, be divided into five groups at random.Dosage gastric infusion as shown in table 2, every day 1 time, continuous 3 days, 1h behind the last medicine, the two sides is coated with the dimethylbenzene (100%) of 0.1ml before and after each Mus left side ear, auris dextra is as own control, animal is put to death in the cervical vertebra dislocation behind the 4h, with diameter 9mm diameter card punch, lays round auricle in each Mus left and right sides ear same area, left and right sides auricle weight difference is the swelling degree, calculates swelling degree and inhibitory rate of intumesce.The results are shown in Table 2.
Table 2 this product xylol causes the influence of mice auricle swelling
*P＜0.05
The result as seen, this product can obviously suppress the mice auricle swelling that caused by dimethylbenzene.
4.3 mice acetic acid is caused the influence of peritoneum inflammatory exudation
Get 50 of mices, be divided into five groups at random, press the gastric infusion of dosage shown in the table 3, every day 1 time, continuous 3 days.1h behind the last medicine, mouse tail vein injection 0.5% azovan blue (0.2ml/ Mus), and lumbar injection 0.6% acetic acid (0.2ml/ Mus) immediately, injection back 30min puts to death mice, uses the normal saline flushing abdominal cavity, collects whole flushing liquors to 10ml, get supernatant after centrifugal and measure the OD value in 630nm wavelength place, with the concentration of azovan blue in the OD value representation flushing liquor, reflect the degree of peritoneum inflammatory exudation indirectly, the results are shown in Table 3.
Table 3 this product causes the influence of peritoneum inflammatory exudation to mice acetic acid
| Group | G crude drug/kg | Number of animals n | OD value X ± SD | Suppression ratio (%) |
| Matched group FUYANKANG PIAN this product 20.97 this product 10.49 this product 5.25 | - 3.51g/kg | 10 10 10 10 10 | 0.424±0.109 0.275±0.117** 0.284±0.102** 0.300±0.143* 0.390±0.115 | 35.14 33.02 29.25 8.02 |
*＜0.05.**p＜0.01
The result as seen, the OD value of this product height, middle dosage group all is lower than matched group, significant difference illustrates that this product causes the peritoneum inflammatory exudation to mice acetic acid certain inhibitory action is arranged.
5, acute toxicity testing:
This product is not less than 225.20g crude drug/kg for the mouse stomach maximum dosage-feeding with Cmax 1.88g crude drug/ml, maximum volume 0.4ml/10g body weight, observed 15 after the administration, do not observe 15 after seeing toxic reaction and dead medicine, do not have drug-induced acute toxic reaction and death.
6, in conjunction with the embodiments the present invention is further described, but the present invention is not subjected to any restriction of embodiment.
Embodiment 1 (tablet)
Prescription:
Leontopodium leontopodioides (Willd.) Beauv. 345g Cortex Phellodendri 215g Cortex Fraxini 360g
Radix Zanthoxyli 295g Radix Paeoniae Rubra 260g Rhizoma Cyperi 105g
Method for making:
Six-element in the side, Rhizoma Cyperi is ground into fine powder, and is standby.Cortex Phellodendri, Cortex Fraxini, Radix Zanthoxyli are ground into coarse powder, add 6 times of amount 70% ethanol extractions 2 times, and each 3 hours, merge extractive liquid, filtered, and filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.30～1.35 (60 ℃), and is standby.All the other Leontopodium leontopodioides (Willd.) Beauv., Radix Paeoniae Rubra two flavors add 10 times of water gagings and decoct 2 times, and each 2 hours, collecting decoction, filter, filtrate decompression is concentrated into the thick paste that relative density is 1.30～1.35 (60 ℃), adds above-mentioned fine powder and thick paste, mixing, drying is pulverized, add appropriate amount of starch, mixing is with 95% ethanol system granule, drying, granulate, tabletting, the bag film-coat is made 1000, promptly.
Embodiment 2 (capsule)
Prescription:
Leontopodium leontopodioides (Willd.) Beauv. 345g Cortex Phellodendri 215g Cortex Fraxini 360g
Radix Zanthoxyli 295g Radix Paeoniae Rubra 260g Rhizoma Cyperi 105g
Method for making:
Six-element in the side, Rhizoma Cyperi is ground into fine powder, and is standby.Cortex Phellodendri, Cortex Fraxini, Radix Zanthoxyli are ground into coarse powder, add 6 times of amount 70% ethanol extractions 2 times, and each 3 hours, merge extractive liquid, filtered, and filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.30～1.35 (60 ℃), and is standby.All the other Leontopodium leontopodioides (Willd.) Beauv., Radix Paeoniae Rubra two flavors add 10 times of water gagings and decoct 2 times, and each 2 hours, collecting decoction, filter, filtrate decompression is concentrated into the thick paste that relative density is 1.30～1.35 (60 ℃), adds above-mentioned fine powder and thick paste, mixing, drying is pulverized, add appropriate amount of starch, mixing is with 95% ethanol system granule, drying, granulate, encapsulated, make 1000, promptly.
Claims (5)
1, a kind of Chinese traditional compound medicine that is used for the treatment of gynecological inflammation is characterized in that it is to be made by following raw material:
Leontopodium leontopodioides (Willd.) Beauv. 30-500g Cortex Phellodendri 15-300g Cortex Fraxini 25-450g
Radix Zanthoxyli 30-400g Radix Paeoniae Rubra 20-300g Rhizoma Cyperi 1-200g.
2, Chinese medicine preparation according to claim 1 is characterized in that it is to be made by the following weight proportion raw material:
Leontopodium leontopodioides (Willd.) Beauv. 345g Cortex Phellodendri 215g Cortex Fraxini 360g
Radix Zanthoxyli 295g Radix Paeoniae Rubra 260g Rhizoma Cyperi 105g.
3, the preparation method of Chinese medicine preparation according to claim 1 and 2 is characterized in that:
A, Rhizoma Cyperi are ground into fine powder, and be standby;
B, Cortex Phellodendri, Cortex Fraxini, Radix Zanthoxyli are ground into coarse powder, add 3-10 and doubly measure the 30-80% ethanol extraction 2 times, and each 2-3 hour, merge extractive liquid, filtered, and filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.30～1.35 (60 ℃), and is standby;
C, Leontopodium leontopodioides (Willd.) Beauv., Radix Paeoniae Rubra add 6-12 times of water gaging and decoct 2-3 time, and each 1-3 hour, collecting decoction filtered, and filtrate decompression is concentrated into the thick paste that relative density is 1.30～1.35 (60 ℃), and is standby;
D, fine powder and thick paste that above-mentioned a, b and C item are made, mixing, drying is pulverized, and adds appropriate amount of starch, mixing, with 50%～95% ethanol system granule, drying, granulate is made solid preparation, promptly.
4, the preparation method of Chinese medicine preparation according to claim 3 is characterized in that:
A, Rhizoma Cyperi are ground into fine powder, and be standby;
B, Cortex Phellodendri, Cortex Fraxini, Radix Zanthoxyli are ground into coarse powder, add 6 times of amount 70% ethanol extractions 2 times, and each 3 hours, merge extractive liquid, filtered, and filtrate recycling ethanol also is concentrated into the thick paste that relative density is 1.30～1.35 (60 ℃), and is standby;
C, Leontopodium leontopodioides (Willd.) Beauv., Radix Paeoniae Rubra add 10 times of water gagings and decoct 2 times, and each 2 hours, collecting decoction filtered, and filtrate decompression is concentrated into the thick paste that relative density is 1.30～1.35 (60 ℃), adds above-mentioned fine powder and thick paste, and is standby;
D, with fine powder and thick paste mixing that above-mentioned a, b and C item make, drying is pulverized, and adds appropriate amount of starch, mixing, with 95% ethanol system granule, drying, granulate is made solid preparation, promptly.
5, has heat-clearing and toxic substances removing dampness, the effect of blood-activating analgetic according to claim 1 and 2 described Chinese medicine preparation.Being mainly used in Chinese medical discrimination belongs to the evil stasis of blood of damp and hot poison and forges the chronic pelvic inflammatory disease of burnt syndrome, the treatment of bacterial vaginitis.Disease is seen: pudendal pruritus, profuse leukorrhea, yellow skin matter are thick, inferior belly gas pain or twinge, and abdominal pain in menstruation increases the weight of, lumbus sacrum pain, and yellow urine is hard and dry or half congealed and not well, red tongue or dark red, or purple spots at the margin and tip of the tongue or ecchymosis, yellow and greasy fur or white greasy, stringy and rolling pulse or string are puckery.
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| CNB2006100172978A CN100455309C (en) | 2006-11-03 | 2006-11-03 | Compound Chinese medicinal preparation for treating gynecological inflammation and preparation method thereof |
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| CN100455309C CN100455309C (en) | 2009-01-28 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101822735A (en) * | 2010-05-24 | 2010-09-08 | 吉林大学 | Medicine composite treating colpitis and preparation method of corresponding foam spraying agent |
| CN102357168A (en) * | 2011-10-10 | 2012-02-22 | 赵全成 | Chinese medicinal composition for treating gynecological diseases and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1820780A (en) * | 2005-02-19 | 2006-08-23 | 李砚秋 | Method for preparing Fuyankang extract |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101822735A (en) * | 2010-05-24 | 2010-09-08 | 吉林大学 | Medicine composite treating colpitis and preparation method of corresponding foam spraying agent |
| CN102357168A (en) * | 2011-10-10 | 2012-02-22 | 赵全成 | Chinese medicinal composition for treating gynecological diseases and preparation method thereof |
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| CN100455309C (en) | 2009-01-28 |
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Effective date of registration: 20160105 Address after: 130103, Shunda road 1369, hi tech Zone, Jilin, Changchun Patentee after: Jilin xiuzheng pharmaceutical new medicine development Co., Ltd. Address before: 130021 No. 509 Mao Xiang street, hi tech Industrial Development Zone, Jilin, Changchun Patentee before: Zhao Quancheng |
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Granted publication date: 20090128 Termination date: 20181103 |