CN104888140A - Traditional Chinese medicine preparation for treatment of wind-heat skin-accumulating type pityriasis rosea and preparation method of traditional Chinese medicine preparation - Google Patents
Traditional Chinese medicine preparation for treatment of wind-heat skin-accumulating type pityriasis rosea and preparation method of traditional Chinese medicine preparation Download PDFInfo
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Abstract
The invention belongs to the technical field of medicines and particularly relates to a traditional Chinese medicine preparation for treatment of wind-heat skin-accumulating type pityriasis rosea and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation comprises components of fructus forsythiae, radix curcumae, safflower carthamus, cortex dictamni, silver purple salvia miltiorrhiza, schizonepeta, fructus kochiae, periostracum cicada, safflower carthamus, caltrops, folium isatidis, campsis grandiflora and the like. The traditional Chinese medicine preparation is definite in treatment effect, high in safety, low in recurrence rate and capable of serving as the effective medicine for treatment of the wind-heat skin-accumulating type pityriasis rosea.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of Chinese medicine preparation for the treatment of wind heat and accumulateing skin type pityriasis rosea.
Background technology
Pityriasis rosea be a kind of rash color as Flos Rosae Rugosae, have the acute inflammation dermatoses of pityrosporum shape desquamation.Originally often send out the larger erythra in trunk, cervical region or extremity somewhere, be called mother's mark, after about 1-2 week, occur secondary speckle, and have pruritus in various degree.Its etiology unknown, is more common in season in spring and autumn, and the course of disease, in 6-8 week, generally can disappear voluntarily, but also have the small number of patients course of disease to continue half a year to the several years, therefore the therapeutic purposes of primary disease are to shorten the course of disease, mitigation symptoms.The traditional Chinese medical science claims pityriasis rosea to be " pityriasis rosea " or " mother and sons' tinea " etc., thinks that primary disease is many by the pungent savoury of surfeit, or depressed emotion, with the passing of time fire-transformation, and accumulate in hyperamization heat, feel ailment said due to cold or exposure again, closing skin space between skin and muscles forms.In recent years, pityriasis rosea patient showed increased, has a strong impact on patients ' life quality.Current doctor trained in Western medicine, without specific medicament, generally gives the symptomatic treatment such as antihistamine drug, external Hormonal ointment, and side effect is large, DeGrain, can only relief of symptoms, cures the symptoms, not the disease, easily repeatedly.Chinese medicine pityriasis rosea long history, method is various, classification therapy, Special medicine for special disease, and modern traditional Chinese patent medicine convenient oral, and side effect is little, so the hope sight for the treatment of pityriasis rosea is turned to tcm field by increasing scholar.
Summary of the invention
The invention provides a kind of wind heat for the treatment of and accumulate Chinese medicine preparation of skin type pityriasis rosea and preparation method thereof, its determined curative effect, safety is high, effectively can alleviate the symptoms such as pruritus, skin lesion number, erythema, squama, and reduce its relapse rate, can be used as the ideal medicament that treatment wind heat accumulates skin type pityriasis rosea.Chinese medicine preparation prescription of the present invention is rigorous, and compatibility science is easy to prepare, and patient compliance is good, without any side effects, and clinic is applied.
For achieving the above object, technical scheme provided by the invention is the Chinese medicine preparation that described treatment wind heat accumulates skin type pityriasis rosea, is made up of the medicine of following weight proportion: Fructus Forsythiae 18-22g, Radix Curcumae 11-15g, Flos Carthami 1-5g, Cortex Dictamni 3-7g, silver-colored Radix Salviae Miltiorrhizae 8-12g, Herba Schizonepetae 10-14g, Fructus Kochiae 8-12g, Periostracum Cicadae 5-9g, Fructus Tribuli 3-6g, Folium Isatidis 7-11g, Flos Campsis 13-17g.
Most preferred technique scheme of the present invention is that Chinese medicine preparation of the present invention is obtained by the material medicine of following weight proportion: Fructus Forsythiae 20g, Radix Curcumae 13g, Flos Carthami 3g, Cortex Dictamni 5g, silver-colored Radix Salviae Miltiorrhizae 10g, Herba Schizonepetae 12g, Fructus Kochiae 10g, Periostracum Cicadae 7g, Fructus Tribuli 5g, Folium Isatidis 9g, Flos Campsis 15g.
Present invention also offers the preparation method of described Chinese medicine preparation, specifically comprise: take above Chinese medicine component according to aforesaid weight and be ground into coarse powder respectively, add medicine gross weight 4-8 soak by water doubly 2-3 time at every turn, each decoction 2-3 hour, merge decoction liquor, filter, concentrated; Medicinal liquid adds ethanol when being slightly cooled to room temperature makes precipitation, makes alcohol content reach 75%, leaves standstill 48 hours, filter, filtrate recycling ethanol is to concentrated, dry, pulverize to obtain traditional Chinese medicine fine powder, eventually pass normal process steps and add pharmaceutically acceptable excipients and make clinical acceptable dosage form.
Chinese medicine preparation of the present invention can be prepared into oral formulations.Preferably be prepared into capsule or tablet.
When above-mentioned oral formulations is capsule, its prescription is:
| Traditional Chinese medicine fine powder | 110-140g |
| Sucrose | 60-80g |
| Magnesium stearate | 1-3g |
Obtained 1000.
The preparation method of described capsule, has the following steps: traditional Chinese medicine fine powder crosses 80 mesh sieves, with cross the sucrose of 80 mesh sieves, magnesium stearate mixs homogeneously, capsule charge and get final product.
The present invention, relative to prior art, has following clear superiority:
First, the pathogenic characteristic that Chinese medicine preparation prescription of the present invention mainly accumulates skin type pityriasis rosea patient according to wind heat develops, Fructus Forsythiae in side, Cortex Dictamni, Folium Isatidis, heat-clearing and toxic substances removing, and dispel the wind speckle removing; Radix Curcumae, Flos Campsis, promoting QI circulation for relieving depression, cooling blood and removing stasis; Flos Carthami, silver-colored Radix Salviae Miltiorrhizae, Fructus Tribuli, promoting blood circulation to restore menstrual flow, dissipating blood stasis detoxifies; Herba Schizonepetae, Periostracum Cicadae, induce sweat loose wind, heat extraction rash; The Fructus Kochiae, clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching; All medicines share, and play heat-clearing and toxic substances removing altogether, eliminating blood stasis and removing ecchymoses, the special effect of dispelling wind for relieving itching, and accumulateing skin type pityriasis rosea to wind heat has extremely strong specific aim curative effect.Through clinical practice checking, its determined curative effect, mild in medicine property and, have no side effect, not easily recur, safety coefficient is high.
Secondly, this Chinese medicine preparation dosage form is advanced, and patient tolerability is good, and preparation is simple, is suitable for large technological process to be produced, gained capsule of the present invention, and stripping is rapid, and the basic stripping completely of 5min, demonstrates superiority of the present invention further.
Further, in Chinese medicine preparation of the present invention, the function of each crude drug cures mainly:
Fructus Forsythiae, bitter, be slightly cold.Return lung, the heart, small intestine meridian.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease from the beginning of, warmly join the army, high hot excessive thirst, coma sends out speckle, pyretic stranguria urine retention.
Radix Curcumae, pungent, bitter, cold.Return liver, the heart, lung meridian.Promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs.Control all pains of breast abdomen side of body rib, lose the heart demented, calentura coma, spit blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.
Flos Carthami, pungent, temperature.GUIXIN, Liver Channel.Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia ， mass in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache.
Cortex Dictamni is bitter, cold.Return spleen, stomach, urinary bladder channel.Heat clearing and damp drying, removing toxic substances of dispeling the wind.For damp and hot sore, yellow fluid is dripping, eczema, rubella, scabies skin ulcer leprosy, beriberoid pyretic arthralgia, jaundice dark coloured urine.
Silver Radix Salviae Miltiorrhizae, sweet in the mouth; Bitter; Property is put down; Blood circulation promoting and blood stasis dispelling; Eliminating damp, detoxifying.Main thoracic obstruction angor; Menoxenia; Dysmenorrhea; Prolapse of the uterus metrorrhagia; Leucorrhea with red and white discharge; Malignant boil toxic swelling.
Herba Schizonepetae, pungent, tepor.Return lung, Liver Channel.Induce sweat loose wind, rash.For flu, headache, measles, rubella, skin infection from the beginning of.Parch to black treating hematochezia, metrorrhagia, puerperal blood faints.
The Fructus Kochiae is pungent, bitter, cold.Return kidney, urinary bladder channel.Clearing away heat-damp and promoting diuresis, dispelling wind for relieving itching.For difficulty and pain in micturition, pudendal pruritus leukorrhagia, rubella, eczema, skin pruritus.
Periostracum Cicadae, sweet, cold.Return lung, Liver Channel.Loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus.
Fructus Tribuli, pungent, bitter, tepor; Slightly poisonous.Return Liver Channel.Suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind, improving eyesight, antipruritic.Dizzy for having a headache, distending pain in the chest and hypochondrium, breast closes acute mastitis, cataract, rubella pruritus.
Folium Isatidis, bitter, cold.GUIXIN, stomach warp.Heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.Join the army for pathogenic warmth, unconsciousness due to high fever, sends out speckle dermexanthesis, jaundice, hematodiarrhoea, mumps, sore throat, erysipelas, carbuncle.
Flos Campsis is sweet, sour, cold.Return liver, pericardium channel.Removing heat from blood, blood stasis dispelling, dispels the wind.For menoxenia, Jing Bi WEIJIA, puerperal swelling of the breast, rubella is rubescent, skin pruritus, acne.
The present invention also asks to protect above-mentioned Chinese medicine preparation to accumulate purposes in the medicine of skin type pityriasis rosea in preparation treatment wind heat.In clinical observation process, treat by 80 routine wind heat are accumulate skin type pityriasis rosea patient, clinical effectiveness shows, after wind heat accumulates skin type pityriasis rosea disease patient treatment, symptom can significantly improve.And body weight, heart rate, blood pressure are showed no obvious change before and after treatment.In whole therapeutic process, do not find the significantly adverse events such as irritated, it is low to follow up a case by regular visits to relapse rate.Synthesis result shows that the clinical application of we is safely and effectively, is worth studying and applying further.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, but the present invention is not limited only to following specific embodiment.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1 capsule
The each raw material of the present invention is taken: Fructus Forsythiae 20g, Radix Curcumae 13g, Flos Carthami 3g, Cortex Dictamni 5g, silver-colored Radix Salviae Miltiorrhizae 10g, Herba Schizonepetae 12g, Fructus Kochiae 10g, Periostracum Cicadae 7g, Fructus Tribuli 5g, Folium Isatidis 9g, Flos Campsis 15g by following weight proportion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight and be ground into coarse powder respectively, add the soak by water 3 times of medicine gross weight 6 times at every turn, to decoct 2 hours at every turn, merge decoction liquor, filter, concentrated; Medicinal liquid adds ethanol when being slightly cooled to room temperature makes precipitation, makes alcohol content reach 75%, leaves standstill 48 hours, filters, and filtrate recycling ethanol, to concentrated, dry, pulverize to obtain traditional Chinese medicine fine powder, for subsequent use.Get traditional Chinese medicine fine powder 130g and cross 80 mesh sieves, mix homogeneously with sucrose 70g, the magnesium stearate 1g crossing 80 mesh sieves, filling, obtains capsule 1000.
When using Chinese medicine preparation of the present invention treatment wind heat to accumulate skin type pityriasis rosea, use prepared capsule, each 2-4 grain, every day 3 times.
Embodiment 2 capsule
The each raw material of the present invention is taken: Fructus Forsythiae 20g, Radix Curcumae 13g, Flos Carthami 3g, Cortex Dictamni 5g, silver-colored Radix Salviae Miltiorrhizae 10g, Herba Schizonepetae 12g, Fructus Kochiae 10g, Periostracum Cicadae 7g, Fructus Tribuli 5g, Folium Isatidis 9g, Flos Campsis 15g by following weight proportion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight and be ground into coarse powder respectively, add the soak by water 2 times of medicine gross weight 4 times at every turn, to decoct 2 hours at every turn, merge decoction liquor, filter, concentrated; Medicinal liquid adds ethanol when being slightly cooled to room temperature makes precipitation, makes alcohol content reach 75%, leaves standstill 48 hours, filters, and filtrate recycling ethanol, to concentrated, dry, pulverize to obtain traditional Chinese medicine fine powder, for subsequent use.Get traditional Chinese medicine fine powder 110g and cross 80 mesh sieves, mix homogeneously with sucrose 80g, the magnesium stearate 3g crossing 80 mesh sieves, filling, obtains capsule 1000.
When using Chinese medicine preparation of the present invention treatment wind heat to accumulate skin type pityriasis rosea, use prepared capsule, each 2-4 grain, every day 3 times.
Embodiment 3 capsule
The each raw material of the present invention is taken: Fructus Forsythiae 20g, Radix Curcumae 13g, Flos Carthami 3g, Cortex Dictamni 5g, silver-colored Radix Salviae Miltiorrhizae 10g, Herba Schizonepetae 12g, Fructus Kochiae 10g, Periostracum Cicadae 7g, Fructus Tribuli 5g, Folium Isatidis 9g, Flos Campsis 15g by following weight proportion.
Preparation technology is as follows:
Take above Chinese medicine component according to aforesaid weight and be ground into coarse powder respectively, add the soak by water 2 times of medicine gross weight 8 times at every turn, to decoct 2 hours at every turn, merge decoction liquor, filter, concentrated; Medicinal liquid adds ethanol when being slightly cooled to room temperature makes precipitation, makes alcohol content reach 75%, leaves standstill 48 hours, filters, and filtrate recycling ethanol, to concentrated, dry, pulverize to obtain traditional Chinese medicine fine powder, for subsequent use.Get traditional Chinese medicine fine powder 140g and cross 80 mesh sieves, mix homogeneously with sucrose 70g, the magnesium stearate 1g crossing 80 mesh sieves, filling, obtains capsule 1000.
When using Chinese medicine preparation of the present invention treatment wind heat to accumulate skin type pityriasis rosea, use prepared capsule, each 2-4 grain, every day 3 times.
Embodiment 4
The each raw material of the present invention is taken: Fructus Forsythiae 18g, Radix Curcumae 11g, Flos Carthami 1g, Cortex Dictamni 3g, silver-colored Radix Salviae Miltiorrhizae 8g, Herba Schizonepetae 10g, Fructus Kochiae 8g, Periostracum Cicadae 5g, Fructus Tribuli 3g, Folium Isatidis 7g, Flos Campsis 13g by following weight proportion.
Preparation technology is with embodiment 1.
Embodiment 5
The each raw material of the present invention is taken: Fructus Forsythiae 22g, Radix Curcumae 15g, Flos Carthami 5g, Cortex Dictamni 7g, silver-colored Radix Salviae Miltiorrhizae 12g, Herba Schizonepetae 14g, Fructus Kochiae 12g, Periostracum Cicadae 9g, Fructus Tribuli 6g, Folium Isatidis 11g, Flos Campsis 17g by following weight proportion.
Preparation technology is with embodiment 1.
Embodiment 6 Chinese medicine preparation treatment of the present invention wind heat accumulates the clinical observation of skin type pityriasis rosea
1, case-data:
Select institute of traditional Chinese medicine Dermatology Outpatient Department to be diagnosed as wind heat and accumulate skin type pityriasis rosea patient 80 example, age 18-45 year, 32 years old mean age, the course of disease is all in 2 weeks.According to random digits table, patient is divided into treatment group and each 40 examples of matched group.
Man 22 example in treatment group, female 18 example; Course of disease < 1 week 21 example, 1 ~ 2 week 19 example.Man 19 example in matched group, female 21 example; Course of disease < 1 week 20 example, 1 ~ 2 week 20 example.The comparing difference not statistically significants (P > 0.05) such as two groups of ages, sex, the course of disease and coincident with severity degree of conditions, have comparability.
2, diagnostic criteria:
2.1 Western medicine diagnose standards:
With reference to the diagnostic criteria of " skin cypridology " pityriasis rosea, from the beginning of the rose-colored light red speckle that skin lesion is isolated, on be covered with thin thin squama, 1-2 week collare, trunk and extremity near-end engender the rose-colored light red speckle of the ellipse differed in size, the same mother's mark of shape, edge is covered with the inside thin thin squama of free edge; Skin lesion major axis is parallel with dermatoglyph; Skin lesion is itched with fullying recover from an illness in various degree.
2.2 Standards of Chinese Medical Syndrome Differentiations:
Meet " Chinese medical disease Standardization of diagnosis and curative effect " wind heat and accumulate skin type: fall ill hurried, the rounded or oval light red patch of skin lesion, there is fine lines at center, and a small amount of thin bran shape squama in surface, companion's restlessness and thirst, large dry stool, urinates micro-Huang.Red tongue, Tai Bai or BOHUANG, the micro-number of stringy and rolling pulse.
3, case is selected in and exclusion standard:
3.1 case inclusion criterias:
(1) clinical diagnosis is that wind heat accumulates skin type pityriasis rosea;
(2) antihistamine drug of other any types was not used in fortnight;
(3) treatments period is without other antihistamine drug.
3.2 exclusion standards:
(1) there is serious adverse reaction and therapy discontinued person;
(2) anemia of pregnant woman or have serious liver, kidney disease patient.
(3) doctor's advice medication can not be observed and can not observe by not selected this of further consultation person on time.
4, Therapeutic Method
Treatment group: use capsule prepared by embodiment 1, each 3, every day 3 times, bfore meals.
Matched group: each 10mg of oral hydrochloride cetirizine sheet, every day 1 time, each 0.1g of vitamin C, every day 3 times.
Above two groups are 7 days 1 courses for the treatment of, observe the therapeutic outcome after 2 courses for the treatment of and 4 courses for the treatment of respectively.The foods such as period in a medicine diet fish shrimp crab shellfish, pungent stimulation.
5, the standard of curative effect evaluation:
Curative effect determinate standard is formulated with reference to " disease of tcm Standardization of diagnosis and curative effect ".
Recovery from illness: erythra all disappears, sufferings sense disappears, and only stays pigmentation;
Effective: erythra quantity reduces >=60%, and sufferings obviously alleviate;
Effective: erythra quantity reduces 30%-60%, and sufferings alleviate;
Invalid: the minimizing of erythra quantity is less than 30%, or increases on the contrary, and sufferings are without alleviating or increasing the weight of on the contrary.
Treatment total effective rate=cure rate+obvious effective rate.
6, safety indexes:
The untoward reaction that inquiry time each medical after medication record patient may occur and degree, comprise the xerosis cutis that may occur, xerostomia, sleepy, drowsiness, and headache is dizzy, exciting, symptom of digestive tract, anaphylaxis and blood, routine urinalysis, hepatic and renal function inspection.
7, therapeutic effect:
In clinical observation process, without coming off, exiting case, 80 routine patients all complete clinical observation.
After 2 courses for the treatment of, clinical effectiveness shows, treatment group recovery from illness 17 example, and effective 15, effective 8 examples, invalid 0 example, total effective rate 80%.Matched group recovery from illness 11 example, effective 8 examples, effective 16 examples, invalid 5 examples, total effective rate 47.5%.
After 4 courses for the treatment of terminate, clinical effectiveness shows, treatment group recovery from illness 26 example, and effective 12, effective 2 examples, invalid 0 example, total effective rate 95%.Matched group recovery from illness 16 example, effective 12 examples, effective 9 examples, invalid 3 examples, total effective rate 70%.Treatment group combined therapy effect is obviously better than matched group.
Illustrate thus, after wind heat accumulates the Chinese medicine preparation treatment of skin type pityriasis rosea disease patient the application of the invention, symptom can significantly improve.In addition, to the detection contrast of safety indexes, treatment group is before the treatment afterwards by finding that treatment group does not occur obvious side effect in whole therapeutic process.In the 26 routine patients that treatment group is cured, follow up a case by regular visits to 1 and be only 2 example recurrences, and symptom is slight.Illustrate that Chinese medicine preparation of the present invention treatment wind heat accumulates skin type pityriasis rosea determined curative effect thus, safety is high, and relapse rate is low, can be used as the active drug that treatment wind heat accumulates skin type pityriasis rosea.
Claims (9)
1. treat the Chinese medicine preparation that wind heat accumulates skin type pityriasis rosea, it is characterized in that, the composition and ratio of its primary raw material medicine is: Fructus Forsythiae 18-22g, Radix Curcumae 11-15g, Flos Carthami 1-5g, Cortex Dictamni 3-7g, silver-colored Radix Salviae Miltiorrhizae 8-12g, Herba Schizonepetae 10-14g, Fructus Kochiae 8-12g, Periostracum Cicadae 5-9g, Fructus Tribuli 3-6g, Folium Isatidis 7-11g, Flos Campsis 13-17g.
2. a kind of Chinese medicine preparation for the treatment of wind heat and accumulateing skin type pityriasis rosea as claimed in claim 1, it is characterized in that, the composition and ratio of its primary raw material medicine is: Fructus Forsythiae 20g, Radix Curcumae 13g, Flos Carthami 3g, Cortex Dictamni 5g, silver-colored Radix Salviae Miltiorrhizae 10g, Herba Schizonepetae 12g, Fructus Kochiae 10g, Periostracum Cicadae 7g, Fructus Tribuli 5g, Folium Isatidis 9g, Flos Campsis 15g.
3. a kind of Chinese medicine preparation for the treatment of wind heat and accumulateing skin type pityriasis rosea as claimed in claim 1 or 2, it is characterized in that, the preparation method of described Chinese medicine preparation comprises following steps: take above Chinese medicine component according to aforesaid weight and be ground into coarse powder respectively, add medicine gross weight 4-8 soak by water doubly 2-3 time at every turn, each decoction 2-3 hour, merge decoction liquor, filter, concentrated; Medicinal liquid adds ethanol when being slightly cooled to room temperature makes precipitation, makes alcohol content reach 75%, leaves standstill 48 hours, filter, filtrate recycling ethanol is to concentrated, dry, pulverize to obtain traditional Chinese medicine fine powder, eventually pass normal process steps and add pharmaceutically acceptable excipients and make clinical acceptable dosage form.
4. a kind of Chinese medicine preparation for the treatment of wind heat and accumulateing skin type pityriasis rosea as claimed in claim 3, it is characterized in that, described Chinese medicine preparation can be made into oral formulations.
5. a kind of Chinese medicine preparation for the treatment of wind heat and accumulateing skin type pityriasis rosea as claimed in claim 4, it is characterized in that, described oral formulations is capsule or tablet.
6. a kind of Chinese medicine preparation for the treatment of wind heat and accumulateing skin type pityriasis rosea as claimed in claim 5, it is characterized in that, described oral formulations is preferably capsule.
7. a kind of Chinese medicine preparation for the treatment of wind heat and accumulateing skin type pityriasis rosea as claimed in claim 6, it is characterized in that, described capsule prescription is:
Traditional Chinese medicine fine powder 110-140g
Sucrose 60-80g
Magnesium stearate 1-3g
Obtained 1000.
8. a kind of Chinese medicine preparation for the treatment of wind heat and accumulateing skin type pityriasis rosea as claimed in claim 7, it is characterized in that, the preparation method of described capsule comprises following steps: traditional Chinese medicine fine powder crosses 80 mesh sieves, with cross the sucrose of 80 mesh sieves, magnesium stearate mixs homogeneously, capsule charge and get final product.
9. medicine as claimed in claim 1 or 2 accumulates the purposes in the medicine of skin type pityriasis rosea in preparation treatment wind heat.
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