CN107982299A - A kind of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran concocting method of eutectic reagent protection - Google Patents
A kind of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran concocting method of eutectic reagent protection Download PDFInfo
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- CN107982299A CN107982299A CN201810000222.1A CN201810000222A CN107982299A CN 107982299 A CN107982299 A CN 107982299A CN 201810000222 A CN201810000222 A CN 201810000222A CN 107982299 A CN107982299 A CN 107982299A
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- stir
- bran
- macrocephalae
- baked rhizoma
- eutectic reagent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
Abstract
The invention discloses a kind of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran concocting method of eutectic reagent protection.The present invention method Rhizoma Atractylodis Macrocephalae is cleaned first, dry after cut into slices, then with eutectic reagent seal after microwave treatment raising active ingredient leaching rate；Finally by honey wheat bran, be sprinkled into stir-frying in hot pot, bighead atractylodes rhizome piece added after smoldering, fry to coke yellow and it is aromatic appear after, sift out after wheat bran to obtain stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran.The content of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran can be significantly improved through stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran concocting method of the present invention, ensures its drug effect.
Description
Technical field
The present invention relates to Chinese medicine preparation field, and in particular to a kind of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran concocting method of eutectic reagent protection.
Background technology
Rhizoma Atractylodis Macrocephalae is the dry rhizome of feverfew Rhizoma Atractylodis Macrocephalae.The main place of production is Hunan, Anhui and Zhejiang, its warm-natured, sweet, taste
Hardship, there is the effect of eliminate dampness and have diuretic effect, strengthening the spleen and replenishing qi, tocolysis, hidroschesis.Cure mainly the burnout caused by dysfunction of the spleen in transportation and transformation, deficiency-weakness of spleen-QI
The symptoms such as weak, abdominal fullness and distention, phlegm and retained fluid oedema, fetal irritability, spontaneous perspiration.Modern pharmacological studies have shown that t Rhizoma Atractylodis Macrocephalaes mainly has
Imitate secondary metabolites ter penoids, that is, atractylodes lactone I, atractylodes lactone II and atractylodes lactone III that component is former plant etc. and come into being
Metabolin polysaccharide, amino acid.Raw atractylodes slice after wheat bran is fried except relaxing pungent dry property, can strengthen its invigorating the spleen to dry, lead it is stagnant
The effect of antidiarrheal.
At present, bran stir-fry method in all parts of the country is basically identical, is all that first wheat bran is placed in pot, adds in pot and stir-fry, emit
After cigarette plus bighead atractylodes rhizome piece, by its frying it is yellowish-brown with slow boiling, takes out, screening is dried in the air cool.During this method frying temperature be mostly 300 DEG C with
On, energy consumption is more, easily loses volatility atractylodes lactone.Based on this, the present invention develops a kind of processing procedure of high atractylodes lactone content
Have the function that for raising atractylodes slice quality important.
The content of the invention
High atractylodes lactone content is prepared in order to realize, it is due that its can also be effectively played under conditions of eating mouth feel is ensured
Effect, the present invention provide a kind of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran concocting method of eutectic reagent protection, it is characterised in that include the following steps：
（1）After quantitative hydrogen-bond donor is mixed with hydrogen bond receptor, when heating 1-3 is small under the conditions of 300-500rpm, 60-80 DEG C
Afterwards, formed and clarify homogeneous eutectic reagent；
（2）Rhizoma Atractylodis Macrocephalae is cleaned, removes impurity, after drying cut into slices after, add Rhizoma Atractylodis Macrocephalae weight 25-35% eutectic reagent sealing after
300-600W power, microwave treatment 10-30min under the conditions of 35-50 DEG C；
（3）Machine for stir-frying Chinese medicine converter rotating speed is adjusted to quick shelves (32rpm/min), the honey wheat bran of Rhizoma Atractylodis Macrocephalae quality 8-12% is taken, is sprinkled into heat
Pot in stir-frying, when smoldering add microwave treatment after bighead atractylodes rhizome piece, fry to coke yellow and it is aromatic appear after, taking-up weed out it is unnecessary
Wheat bran after stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran.
Further, step（1）Described in hydrogen-bond donor be glycerine, urea, ethylene glycol, glucose, one in lactic acid
Kind；The hydrogen bond receptor is choline chloride, glycine betaine, one kind in l-cn；The hydrogen-bond donor adds with hydrogen bond receptor
The molar ratio for entering amount is 2:；A small amount of water can be added in the hydrogen-bond donor and hydrogen bond receptor, addition and the hydrogen bond of water are given
The 1 of the molar ratio of body addition:1-3.
Further, step（2）Described in slice thickness be 2-4mm；The area of the section is not more than 4cm2。
Further, step（3）Described in honey wheat bran preparation method be：The refined honey of wheat bran quality 60% is taken to put preheating
Pot in, add water（The about a quarter of refined honey amount）After dilution, raw wheat bran is poured into, multiplies heat and mixes thoroughly, rub scattered, with slow boiling fry to
Tack-free honey wheat bran to obtain the final product.
Further, step（3）Described in hot pot temperature be 150-200 DEG C, the stir-frying time is 5-10min.
Further, step（3）Described in stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran in atractylodes lactone II content be not less than 0.02%；In Rhizoma Atractylodis Macrocephalae
Ester I, atractylodes lactone II, atractylodes lactone III, total content are not less than 0.06%.
Compared with prior art a kind of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran concocting method of eutectic reagent protection of the present invention have with
Lower beneficial effect, the present invention use green natural, and the eutectic reagent combining ultrasonic technology of good biocompatibility carries out Rhizoma Atractylodis Macrocephalae
Processing, the leaching rate while eutectic reagent but also the active ingredient for absorbing heated volatilization, raising that can increase active ingredient have
The content of component is imitated, shortens concocted time, improves and processes efficiency；Honey wheat bran is prepared using microwave method, spends the time few, effect
Rate is high.
Brief description of the drawings
Fig. 1 is the liquid phase figure of atractylodes lactone mixing reference substance（Atractylodes lactone I, atractylodes lactone II, atractylodes lactone III are
2ug/ml）.
Fig. 2 is the liquid phase figure of atractylodes lactone in the stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran that this patent method obtains.
Peak 1 represents atractylodes lactone III, and peak 2 represents atractylodes lactone I, and peak 3 represents atractylodes lactone II.
Embodiment
Embodiment 1
Choline chloride, glucose, water are pressed 1:2:After 2 mixed in molar ratio, under the conditions of 500rpm, 80 DEG C heating 2 it is small when after,
Formed and clarify homogeneous choline chloride-glucose eutectic reagent；Rhizoma Atractylodis Macrocephalae is cleaned, removes impurity, being cut into thickness after drying is
2-4mm, area are not more than 4cm2Bighead atractylodes rhizome piece after, after adding Rhizoma Atractylodis Macrocephalae to weigh 30% choline chloride-glucose eutectic reagent sealing
The microwave treatment 20min under the conditions of 500W power, 40 DEG C；Machine for stir-frying Chinese medicine converter rotating speed is adjusted to quick shelves, takes Rhizoma Atractylodis Macrocephalae quality 10%
Honey wheat bran, be sprinkled into stir-frying in 180 DEG C of hot pot, the bighead atractylodes rhizome piece after adding microwave treatment when smoldering, is fried after 8min to burnt
Yellow and it is aromatic appear after, taking-up weeds out after unnecessary wheat bran to obtain stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran.
Embodiment 2
L-cn, glycerine, water are pressed 1:2:After 2 mixed in molar ratio, under the conditions of 500rpm, 80 DEG C heating 1.5 it is small when after,
Formed and clarify homogeneous l-cn-glycerine eutectic reagent；Rhizoma Atractylodis Macrocephalae is cleaned, removes impurity, it is 2- that thickness is cut into after drying
4mm, area are not more than 4cm2Bighead atractylodes rhizome piece after, add Rhizoma Atractylodis Macrocephalae weigh after 35% l-cn-glycerine eutectic reagent sealing
600W power, microwave treatment 10min under the conditions of 35 DEG C；Machine for stir-frying Chinese medicine converter rotating speed is adjusted to quick shelves, takes Rhizoma Atractylodis Macrocephalae quality 12%
Honey wheat bran, is sprinkled into stir-frying in 200 DEG C of hot pot, bighead atractylodes rhizome piece when smoldering after addition microwave treatment, to sallow after stir-fry 6min
Color and it is aromatic appear after, taking-up weeds out after unnecessary wheat bran to obtain stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran.
Embodiment 3
Glycine betaine, glycerine, water are pressed 1:2:After 4 mixed in molar ratio, under the conditions of 500rpm, 80 DEG C heating 2 it is small when after, formed
Clarify homogeneous glycine betaine-glycerine eutectic reagent；Rhizoma Atractylodis Macrocephalae is cleaned, removes impurity, it is 2-4mm that thickness is cut into after drying, face
Product is not more than 4cm2Bighead atractylodes rhizome piece after, add Rhizoma Atractylodis Macrocephalae to weigh after 20% glycine betaine-glycerine eutectic reagent sealing in 500W power, 40
Microwave treatment 15min under the conditions of DEG C；Machine for stir-frying Chinese medicine converter rotating speed is adjusted to quick shelves, the honey wheat bran of Rhizoma Atractylodis Macrocephalae quality 12% is taken, spreads
Enter stir-frying in 200 DEG C of hot pot, the bighead atractylodes rhizome piece after adding microwave treatment when smoldering, is fried after 7min to coke yellow and aromatic
After going out, taking-up obtains stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran after weeding out unnecessary wheat bran.
Comparative example
Referenced patent《A kind of processing procedure of honey wheat bran rhizoma atractylodis macrocephalae medicine materical crude slice》104224879 A of CN are operated, specific steps
For：First refined honey and wheat bran are mixed thoroughly, every 25 parts of 100 parts of Rhizoma Atractylodis Macrocephalae refined honeys put frying buff in pot, tack-free, take out, then
Take bighead atractylodes rhizome piece；Machine for stir-frying Chinese medicine is opened after the completion of classification and is heated to 100 DEG C, puts into and medicinal material is put into sweet wheat bran 10- when sweet wheat bran is smoldered
15 parts, constantly stir-frying to medicinal material surface in yellow and it is aromatic appear after, taking-up weeds out after unnecessary wheat bran to obtain stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran.
Rhizoma Atractylodis Macrocephalae sample treatment and quantitative approach
Take Rhizoma Atractylodis Macrocephalae sample appropriate, crush, cross No. four sieves, precision weighs 2 g, puts in conical flask with cover, and precision adds methanol
20 mL, close plug, weighed quality, is ultrasonically treated 30 min, then weighed quality, supplies less loss quality with methanol, shake up, stand, take
Supernatant crosses 0.45 bucket m filter membranes, spare.
The selection of chromatographic condition:Permaphase ODS（The mm of 5um, 150 mm × 4.6)；Mobile phase is methanol water (60：40)；
Detection wavelength, 0-25 min (220 nm), 25~55min (276 nm)；30 DEG C of column temperature；Volume flow 1.0ml/min；Sample introduction
Measure 10uL.
It is atractylodes lactone I in the stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran that the stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran and comparative example that embodiment 1-3 is processed process, atractylodes lactone II, white
Art lactone II I difference is as shown in table 1：
Table 1
| Investigation project | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example |
| Atractylodes lactone I | 0.027% | 0.028% | 0.029% | 0.012% |
| Atractylodes lactone II | 0.032% | 0.037% | 0.035% | 0.011% |
| Atractylodes lactone III | 0.021% | 0.020% | 0.019% | 0.010% |
For the ordinary skill in the art, specific embodiment is simply exemplarily described the present invention, it is clear that
Present invention specific implementation is not subject to the restrictions described above, as long as employing inventive concept and technical scheme of the present invention progress
The improvement of various unsubstantialities, or it is not improved by the present invention design and technical solution directly apply to other occasions,
Within protection scope of the present invention.
Claims (6)
1. a kind of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran concocting method of eutectic reagent protection, it is characterised in that include the following steps：
（1）After quantitative hydrogen-bond donor is mixed with hydrogen bond receptor, when heating 1-3 is small under the conditions of 300-500rpm, 60-80 DEG C
Afterwards, formed and clarify homogeneous eutectic reagent；
（2）Rhizoma Atractylodis Macrocephalae is cleaned, removes impurity, after cutting into slices after drying, adds the eutectic reagent sealing of the 25-35% of Rhizoma Atractylodis Macrocephalae quality
The microwave treatment 10-30min under the conditions of 300-600W power, 35-50 DEG C afterwards；
（3）Machine for stir-frying Chinese medicine converter rotating speed is adjusted to quick shelves (32rpm/min), the honey wheat bran of Rhizoma Atractylodis Macrocephalae quality 8-12% is taken, is sprinkled into heat
Pot in stir-frying, when smoldering add microwave treatment after bighead atractylodes rhizome piece, fry to coke yellow and it is aromatic appear after, taking-up weed out it is unnecessary
Wheat bran after stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran.
A kind of 2. stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran concocting method of eutectic reagent protection according to claim 1, it is characterised in that step
（1）Described in hydrogen-bond donor be glycerine, urea, ethylene glycol, glucose, one kind in lactic acid；The hydrogen bond receptor is chlorine
Change choline, glycine betaine, one kind in l-cn；The molar ratio of the hydrogen-bond donor and hydrogen bond receptor addition is 2:1；It is described
Hydrogen-bond donor and hydrogen bond receptor in can add a small amount of water, the addition of water and the 1 of the molar ratio of hydrogen-bond donor addition:1-
3。
A kind of 3. stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran concocting method of eutectic reagent protection according to claim 1, it is characterised in that step
（2）Described in slice thickness be 2-4mm；The area of the section is not more than 4cm2。
A kind of 4. stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran concocting method of eutectic reagent protection according to claim 1, it is characterised in that step
（3）Described in honey wheat bran preparation method be：Take the refined honey of wheat bran quality 60% to put in the pot of preheating, add water（About refined honey amount
A quarter）After dilution, raw wheat bran is poured into, multiplies heat and mixes thoroughly, rub scattered, fried with slow boiling to tack-free up to honey wheat bran.
A kind of 5. stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran concocting method of eutectic reagent protection according to claim 1, it is characterised in that step
（3）Described in hot pot temperature be 150-200 DEG C, the stir-frying time is 5-10min.
A kind of 6. stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran concocting method of eutectic reagent protection according to claim 1, it is characterised in that step
（3）Described in stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran in atractylodes lactone II content be not less than 0.02%；Atractylodes lactone I, atractylodes lactone II, in Rhizoma Atractylodis Macrocephalae
Ester III, total content are not less than 0.06%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810000222.1A CN107982299A (en) | 2018-01-01 | 2018-01-01 | A kind of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran concocting method of eutectic reagent protection |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810000222.1A CN107982299A (en) | 2018-01-01 | 2018-01-01 | A kind of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran concocting method of eutectic reagent protection |
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| Publication Number | Publication Date |
|---|---|
| CN107982299A true CN107982299A (en) | 2018-05-04 |
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|---|---|---|---|
| CN201810000222.1A Pending CN107982299A (en) | 2018-01-01 | 2018-01-01 | A kind of stir-baked RHIZOMA ATRACTYLDIS MACROCEPHALAE in bran concocting method of eutectic reagent protection |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104224879A (en) * | 2013-06-14 | 2014-12-24 | 铜仁梵净山中药饮片有限公司 | Processing technology of medicinal honey bran roasted rhizoma atractylodis macrocephalae slices |
| CN104887723A (en) * | 2015-06-18 | 2015-09-09 | 天津理工大学 | Method for extracting flavonoids from ginkgo biloba leaves with deep eutectic solvent |
| CN105392363A (en) * | 2013-03-01 | 2016-03-09 | A·S·戈尔兹伯勒 | Sample fixation and stabilisation |
| CN107308684A (en) * | 2017-09-01 | 2017-11-03 | 东莞理工学院 | The microwave auxiliary extraction method of three kinds of lactone compounds in a kind of Ligusticum wallichii |
-
2018
- 2018-01-01 CN CN201810000222.1A patent/CN107982299A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105392363A (en) * | 2013-03-01 | 2016-03-09 | A·S·戈尔兹伯勒 | Sample fixation and stabilisation |
| CN104224879A (en) * | 2013-06-14 | 2014-12-24 | 铜仁梵净山中药饮片有限公司 | Processing technology of medicinal honey bran roasted rhizoma atractylodis macrocephalae slices |
| CN104887723A (en) * | 2015-06-18 | 2015-09-09 | 天津理工大学 | Method for extracting flavonoids from ginkgo biloba leaves with deep eutectic solvent |
| CN107308684A (en) * | 2017-09-01 | 2017-11-03 | 东莞理工学院 | The microwave auxiliary extraction method of three kinds of lactone compounds in a kind of Ligusticum wallichii |
Non-Patent Citations (1)
| Title |
|---|
| JUE CHEN等: ""Deep Eutectic Solvent-Based Microwave-Assisted Method for Extraction of Hydrophilic and Hydrophobic Components from Radix Salviae miltiorrhizae"", 《MOLECULES》 * |
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