CN107982092A - A kind of composition and its application in cosmetics are prepared - Google Patents
A kind of composition and its application in cosmetics are prepared Download PDFInfo
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- CN107982092A CN107982092A CN201711401063.8A CN201711401063A CN107982092A CN 107982092 A CN107982092 A CN 107982092A CN 201711401063 A CN201711401063 A CN 201711401063A CN 107982092 A CN107982092 A CN 107982092A
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- composition
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
Abstract
The present invention relates to cosmetic technical field, more particularly to a kind of composition and its application in cosmetics are prepared.The present invention is rationally compounded chitosan oligosaccharide, chitosan quaternary ammonium salt, collagen, Sodium Hyaluronate, α terpinols, glycerine, acidic materials, said composition can have good raising skin moisture content, reduce the effect that moisture of skin scatters and disappears, and inhibitory action can be produced to the bacterium of skin surface, there is good repair to the scar after acne, fash, cosmetology.And effect is compared compared with each component is used alone or using traditional moisture-keeping composition, all raisings with conspicuousness.Illustrate under appropriate proportioning, each component compounding generates synergistic effect, so as to improve moisturizing, antibacterial, the effect repaired.
Description
Technical field
The present invention relates to cosmetic technical field, more particularly to a kind of composition and its application in cosmetics are prepared.
Background technology
As the improvement of people's living standards, beautiful pursuit is also continuously improved in people, beauty and skin care becomes numerous and likes to be beautiful
The thing that personage pays close attention to jointly.With the increase at age, the moisturizing factor content in keratoderma gradually decreases, and causes skin
Hydratability decline, show as having dry skin, wrinkle, relaxation, the appearance of aging is presented.
Cuticula is the outermost layer of four layer tissues (basalis, spinous layer, stratum granulosum, cuticula) of skin epidermis, by about 30 μ
M wide, the flat hexagonal horn cell composition of 0.8 μ m-thick, generally 10-20 confluent monolayer cells, thickness are 10-15 μm.Epidermis
The superiors also have lipid bilayer to form sebum film, it is the layer protecting film for being mixed and being formed by sweat and sebum.Cuticula
Water absorbing capacity and barrier function make the certain water content of its maintenance and have certain water holding capacity.Skin moisture-keeping depends primarily upon table
The water content of skin, particularly water content of stratum corneum, water content of stratum corneum play decisive role to the appearance of skin.Work as cuticula
When moisture is sufficient, skin emolliency is smooth, fine and smooth, high resilience.
Facial mask is that a thin layer of material is applied on skin of face, completely cuts off skin and outside air when working, makes face
Nutritional ingredient in film is effectively penetrated in skin, plays protection cuticula, increases the effect of skin function.However, current city
The facial mask of field sale mainly includes there are many defects：1st, it is improper to be formulated, and such facial mask can cause because of the overlong time sticked
Nutrient is returned by facial mask back suction, so as to cause some defects such as facial skin drying；2nd, component is bad, in many facial masks all at present
A large amount of chemical synthesis agent are added, long-time service can cause skin necessarily to injure.3rd, function is single, such as：Single moisturizing face
Film cannot have certain antibacterial repair to skin injury (such as being repaired after acne, dermatitis, cosmetology) well.Therefore,
Should further it develop with multi-efficiency, and the facial mask of reasonable component formula.
The content of the invention
In view of this, the technical problem to be solved in the present invention is in a kind of composition of offer and its in cosmetics are prepared
Using.Can have the function that antibacterial, moisturizing and/or reparation with cosmetics made from said composition.
The present invention provides regulation composition and is made of the component of following mass parts：
Chitosan oligosaccharide is called Chitosan poly oligosaccharide, chitosan oligomer, is that chitosan is degraded through special biological enzyme technology
Oligosaccharide product, has obvious moisturizing, activates body cell, prevents pachylosis and aging, suppresses skin surface harmful bacteria and grows
Raw, antibacterial antidermatosis and absorb ultraviolet function and other effects, the molecular weight of the chitosan oligosaccharide used in the present composition for
1000~10000.
Prepared by chitosan quaternary ammonium salt is the chemically modified modification of marine organisms chitosan chitosan higher derivative, tool
There are good antibiotic property, film forming, moisture absorbability and moisture retentivity.The substitution value for the chitosan quaternary ammonium salt that the present invention uses for 50%~
90%.
Collagen is extracted by Animal Skin, also containing albumen such as hyaluronic acid, chondroitin sulfates in addition to collagen in skin
Polysaccharide, they contain a large amount of polar groups, are moisturizing factors, and have the work for preventing the tyrosine in skin from being converted into melanin
With, therefore collagen has the effect such as pure natural moisturizing, whitening, wrinkle resistant, nti-freckle, can be widely applied in cosmetic products.The present invention
The collagen of use is selected from least one of deep-sea fish skin collagen, pigskin collagen, human-like collagen.It is described
Deep-sea fish skin collagen is tilapia fishskin collagen.In the embodiment of the present invention, the molecular weight of the collagen is little
In 1000Da；In some specific embodiments, the molecular weight of the collagen is 800Da~1000Da
Sodium Hyaluronate (HA) is with 1 by n acetylglucosamine n sugar and glucuronic acid by glycosidic bond:1 (molar ratio) group
The disaccharide straight chain macromolecular acid mucopolysaccharide of layer, molecular weight is tens of thousands of a large amount of to existing between millions of dalton, in HA molecules
Hydroxyl (- OH), makes it produce powerful hydrophily, can combine substantial amounts of water, show good performance of keeping humidity.The present invention adopts
The molecular weight of Sodium Hyaluronate is 1000~7000.
Alpha-terpineol, also known as α-terpineol；With graceful lilac fragrance.Glycerine is the thick liquid of water white transparency,
It is odorless, it is pleasantly sweet, warmth sensation is produced after contacting skin, since rule of origin is wide, price is low, has given efficacy, is cosmetics
High-quality moisturizer.
Human skin enlivens substantial amounts of bacterium, if skin is because some reasons cannot maintain oneself normal faintly acid
PH value, skin be can easily due to microorganism growth and some skin diseases, the pH value of cosmetics is adjusted to
Acidity is conducive to the health of skin.In the embodiment of the present invention, the acidic materials are in acetic acid, citric acid, lactic acid, tartaric acid
It is at least one.
In some specific embodiments, composition provided by the invention is made of the component of following mass parts：
In this embodiment, the acidic materials are citric acid；The collagen is molecular weight no more than 1000Da's
Tilapia fishskin collagen；The molecular weight of the chitosan oligosaccharide is 8000~10000.
In some specific embodiments, composition provided by the invention is made of the component of following mass parts：
In this embodiment, the acidic materials are lactic acid；The collagen is not more than the pig of 1000Da for molecular weight
Collagen；The molecular weight of the chitosan oligosaccharide is 5000~8000.
In some specific embodiments, composition provided by the invention is made of the component of following mass parts：
In this embodiment, the acidic materials are acetic acid；The collagen is not more than the class of 1000Da for molecular weight
Human collagen；The molecular weight of the chitosan oligosaccharide is 2000~5000.
Containing natural antibacterial ingredient chitosan oligosaccharide, chitosan quaternary ammonium salt in composition provided by the invention, by through cell
Film, into microbial cell, can combine with intracellular electronegative material (mainly protein and nucleic acid), make cell
Normal physiological function be affected (influence DNA duplication and protein synthesis) etc. there is certain antibacterial effect.And collagen egg
There are amino acid such as the hydroxyprolines and hydroxylysine of a large amount of carboxyls and hydroxyl in white, and the natural moisture preserving such as substantial amounts of glycine
The factor, can improve histiocytic water storage capacity, there is good moistening effect to skin.The life of collagen and Skin Cell
Grow, divide, rise in value, migrate and break up related, skin can be given to provide nutrient, delay skin aging, promotes the surface of a wound of skin
Repair.Combination species each component provided by the invention cooperates, and collaboration promotes antibacterial, moisturizing and repair function, relative to making
For composition with scarce side, composition provided by the invention it is better.
Application of the composition provided by the invention in antibacterial cosmetic is prepared.
Composition provided by the invention is preparing the application in repairing cosmetics.
Application of the composition provided by the invention in moisture-keeping cosmetics are prepared.
After testing, composition provided by the invention is smeared, through transepidermal water loss rate (TEWL) 10%~13%, moisture of skin after 2h
Content is improved to 100%~120%；To skin surface various bacteria (such as：Escherichia coli, staphylococcus aureus) with general
Time inhibitory action.In addition, experiment shows, composition provided by the invention has the scar after acne, fash, cosmetology good
Good repair.
Present invention also offers a kind of cosmetics, including composition provided by the invention.
In cosmetics provided by the invention, the mass fraction of composition is 9.51%~28.05%.
Cosmetics provided by the invention apply some make up for skin care.
The skin applies some make up as mildy wash, water, breast, elite, frost or facial mask.
In some embodiments, cosmetics provided by the invention are facial mask, and the facial mask is made of mask matrix and facial mask liquid.
The mask matrix is non-woven fabrics, pure cotton cloth, fruit fiber, gel (silica gel, agar), silk, plant fiber or micro-
Biological fiber.
In some embodiments, the facial mask liquid in cosmetics is made of the component of following mass fraction：
In one specific embodiment, the facial mask liquid in cosmetics is made of the component of following mass fraction：
In one specific embodiment, the facial mask liquid in cosmetics is made of the component of following mass fraction：
In one specific embodiment, the facial mask liquid in cosmetics is made of the component of following mass fraction：
The preparation method of cosmetics of the present invention includes：
Step 1：Acidic materials are dissolved in the water obtained solution 1；
Step 2：The solution 1 that collagen is dissolved in 1/2 volume prepares solution 2；Chitosan oligosaccharide is molten with chitosan quaternary ammonium salt
In 1 obtained solution 3 of solution of other 1/2 volume；
Step 3：Under stirring condition, glycerine is added dropwise with the speed of 1 drop/s, while successively by Sodium Hyaluronate, alpha-terpineol
It is added into solution 2, solution 3 is then added with the speed of 1mL/min~5mL/min, cosmetics is made.
The speed stirred described in step 3 is 100r/min~500r/min, after addition Sodium Hyaluronate, alpha-terpineol,
Continue to stir 10min~20min.
The preparation of cosmetics of the present invention carries out at room temperature, and the room temperature is 10~30 DEG C.
The present invention is by chitosan oligosaccharide, chitosan quaternary ammonium salt, collagen, Sodium Hyaluronate, alpha-terpineol, glycerine, acid
Matter is rationally compounded, and said composition can have good raising skin moisture content, reduces the work that moisture of skin scatters and disappears
With, and inhibitory action can be produced to the bacterium of skin surface, there is good repair to the scar after acne, fash, cosmetology
Multiple effect.And effect is compared compared with each component is used alone or using traditional moisture-keeping composition, all carrying with conspicuousness
It is high.Illustrate under appropriate proportioning, each component compounding generates synergistic effect, so as to improve moisturizing, antibacterial, the effect repaired
Fruit.
Embodiment
A kind of application the present invention provides composition and its in cosmetics are prepared., those skilled in the art can borrow
Reflect present disclosure, is suitably modified technological parameter realization.In particular, all similar substitutions and modifications are to this area
It is it will be apparent that they are considered as being included in the present invention for technical staff.The method of the present invention and application have passed through
Preferred embodiment is described, related personnel substantially can not depart from present invention, in spirit and scope to the side of this paper
Method and application are modified or suitably change with combining, to realize and using the technology of the present invention.
The examination material that the present invention uses is all common commercially available product, can all be bought in market.
With reference to embodiment, the present invention is further explained：
Embodiment 1~3
Prescription such as table 1：
1 embodiment of table, 1~3 prescription
Step 1：Acidic materials are dissolved into purified water and prepare solution 1；
Step 2：Solution 1 is divided into two parts, collagen is dissolved in acid solution 1 prepares solution 2；By chitosan oligosaccharide with
Chitosan quaternary ammonium salt is dissolved in solution 1 and prepares solution 3.
Step 3：Sodium Hyaluronate, alpha-terpineol are added in solution 2 while stirring one in order, stir speed (S.S.) 100
~500r/min, after 10~20min of stirring is uniform, is slow added into solution 3, addition speed is 1~5ml/min；
Step 4：Glycerine is added dropwise during step 5 is added, 1 drop/s, stirs evenly obtained facial mask liquid.
Using non-woven fabrics as mask matrix, facial mask is made with 25mL facial mask liquids in every mask matrix addition.
Comparative example 1~3
Prescription such as table 2：
2 comparative example of table, 1~3 prescription
Step 1：Acidic materials are dissolved into purified water and prepare solution 1；
Step 2：Solution 1 is divided into two parts, collagen is dissolved in acid solution 1 prepares solution 2；By chitosan oligosaccharide with
Chitosan quaternary ammonium salt is dissolved in solution 1 and prepares solution 3.
Step 3：Sodium Hyaluronate, alpha-terpineol are added in solution 2 while stirring one in order, stir speed (S.S.) 100
~500r/min, after 10~20min of stirring is uniform, is slow added into solution 3, addition speed is 1~5ml/min；
Step 4：Glycerine is added dropwise during step 5 is added, 1 drop/s, stirs evenly obtained facial mask liquid.
Using non-woven fabrics as mask matrix, facial mask is made with 25mL facial mask liquids in every mask matrix addition.
Effect is evaluated and tested
1st, skin moisture content and moisture of skin scatter and disappear detection
60 people of volunteer is randomly selected, the age between 18-40 Sui, is randomly divided into 6 groups, every group of 10 people, clean before tested
Skin of face, then without using any cosmetics or medicine.Six groups of volunteers stick embodiment 1~3 and comparative example 1~3 respectively
The facial mask of preparation, is removed after 20min after fully absorbing facial mask liquid, using Multi-functional skin tester (TEWL) to volunteer's skin
Skin is detected, and test environment temperature is 22 ± 1 DEG C, and humidity is 50 ± 5%, is detected at regular intervals, continuous detection
8h, calculates and obtains MMV values and TEWL values.
MMV=(W1-W0)/W0 × 100%
Wherein：W0=skins use moisture before sample；W1=skins use moisture after sample；
TEWL=(T0-T1)/T0 × 100%
Wherein：T0=skins use moisture before sample；T1=skins use moisture after sample；
As a result such as table 3~4：
The MMV values of 3 each period of table
The TEWL values of 4 each period of table
According to table 3~4, facial mask liquid provided by the invention, each group distribution ratio science, the timely moisture increase of skin
110%, 4h can also keep skin moisture content 70% to increase.It reduces the scatter and disappear ability of TEWL of moisture of skin and greatly promotes, and has
Beneficial to the abundant moisturizing of skin.Compared with comparative example 1~3, the prescription that embodiment 1~3 provides is improving moisture, is suppressing water
Conspicuousness, which is all shown, in terms of the scattered effect lost improves (p<0.05), illustrate that each component compounding plays significant synergy and makees
With.The wherein best results of embodiment 2, are significantly better than embodiment 1 and embodiment 3, p<0.05.
2nd, bactericidal effect detects
Sterilization experiment uses contact method, and tested strain is Escherichia coli, staphylococcus aureus, acne propionic acid bar
Bacterium, given the test agent are facial mask liquid.Using clear water as blank control, each tested strain of sample is set to be repeated three times for experiment.Experimental result
Such as table 5：
5 sterilizing rate of table (%)
The result shows that facial mask stoste provided by the invention can effectively suppress the common bacterium of face, embodiment 1~3
Bacteriostasis rate is significantly higher than comparative example 1~3, p<0.01；The fungistatic effect of the wherein preparation of embodiment 2 facial mask liquid is optimal, for three kinds
The bacteriostasis rate of bacterium is more than other given the test agent.
3rd, repairing effect
Choose 30 people of volunteer there are scar, the age between 18-40 Sui, the wherein volunteer of scar caused by acne
12 people, fash cause 10 people of volunteer of scar, 8 people of volunteer after cosmetology, stick the facial mask of the preparation of embodiment 2 daily, often
Its 20min, is used continuously 7 days, every two days investigation repairing effects, as a result such as table 6.
Repairing effect judges：It is invalid：Have no improvement or even deteriorate；Effectively：Scar lighter, projection have been calmed down；It is aobvious
Effect：Scar color disappears, and projection is calmed down completely.
6 repairing effect of table
The result shows that most of volunteer represents, mask provided by the invention can effectively repair scar, tell on
Time is 3~5 days.
It the above is only the preferred embodiment of the present invention, it is noted that come for those skilled in the art
Say, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications also should be regarded as
Protection scope of the present invention.
Claims (10)
1. a kind of composition, it is characterised in that be made of the component of following mass parts：
2. composition according to claim 1, it is characterised in that the acidic materials be selected from acetic acid, citric acid, lactic acid,
At least one of tartaric acid；
The collagen is selected from least one of deep-sea fish skin collagen, pigskin collagen, human-like collagen.
3. composition according to claim 1, it is characterised in that the molecular weight of the collagen is not more than 1000Da；
The molecular weight of the chitosan oligosaccharide is 1000~10000.
4. composition according to claim 1, it is characterised in that be made of the component of following mass parts：
5. application of the Claims 1 to 4 any one of them composition in antibacterial cosmetic is prepared.
6. Claims 1 to 4 any one of them composition is preparing the application in repairing cosmetics.
7. application of the Claims 1 to 4 any one of them composition in moisture-keeping cosmetics are prepared.
8. a kind of cosmetics, it is characterised in that including Claims 1 to 4 any one of them composition.
9. cosmetics according to claim 8, it is characterised in that be made of the component of following mass fraction：
10. the preparation method of any one of claim 8~9 cosmetics, it is characterised in that including：
Step 1：Acidic materials are dissolved in the water obtained solution 1；
Step 2：The solution 1 that collagen is dissolved in 1/2 volume prepares solution 2；Chitosan oligosaccharide and chitosan quaternary ammonium salt are dissolved in separately
1 obtained solution 3 of solution of outer 1/2 volume；
Step 3：Under stirring condition, glycerine is added dropwise with the speed of 1 drop/s, while successively add Sodium Hyaluronate, alpha-terpineol
Enter in solution 2, solution 3 is then added with the speed of 1mL/min~5mL/min, cosmetics are made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711401063.8A CN107982092A (en) | 2017-12-22 | 2017-12-22 | A kind of composition and its application in cosmetics are prepared |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711401063.8A CN107982092A (en) | 2017-12-22 | 2017-12-22 | A kind of composition and its application in cosmetics are prepared |
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ID=62039547
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109700669A (en) * | 2019-02-20 | 2019-05-03 | 南京先卓生物科技有限公司 | A kind of collagen protein face and preparation method thereof |
| CN112826757A (en) * | 2020-12-16 | 2021-05-25 | 中新国际联合研究院 | Antibacterial and anti-inflammatory composite collagen essence and preparation method and application thereof |
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| CN1587281A (en) * | 2004-07-06 | 2005-03-02 | 浙江大学 | Process for preparing chitosan quaternary ammonium salt |
| CN101816802A (en) * | 2010-02-05 | 2010-09-01 | 佘振定 | Chitosan-based medical dressing |
| CN106176319A (en) * | 2016-08-30 | 2016-12-07 | 青岛博智汇力生物科技有限公司 | A kind of Whitening sunscreen cream containing marine oligosaccharide |
| CN107126375A (en) * | 2017-03-23 | 2017-09-05 | 烟台职业学院 | A kind of cosmetics containing chitosan oligosaccharide and preparation method thereof |
| CN107184961A (en) * | 2017-05-27 | 2017-09-22 | 广州润虹医药科技有限公司 | A kind of competent cell renovation agent and preparation method thereof |
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| CN1587281A (en) * | 2004-07-06 | 2005-03-02 | 浙江大学 | Process for preparing chitosan quaternary ammonium salt |
| CN101816802A (en) * | 2010-02-05 | 2010-09-01 | 佘振定 | Chitosan-based medical dressing |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109700669A (en) * | 2019-02-20 | 2019-05-03 | 南京先卓生物科技有限公司 | A kind of collagen protein face and preparation method thereof |
| CN112826757A (en) * | 2020-12-16 | 2021-05-25 | 中新国际联合研究院 | Antibacterial and anti-inflammatory composite collagen essence and preparation method and application thereof |
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Application publication date: 20180504 |