CN107961329A - A kind of hypoglycemic Xuancheng's pawpaw powder - Google Patents
A kind of hypoglycemic Xuancheng's pawpaw powder Download PDFInfo
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- CN107961329A CN107961329A CN201711412697.3A CN201711412697A CN107961329A CN 107961329 A CN107961329 A CN 107961329A CN 201711412697 A CN201711412697 A CN 201711412697A CN 107961329 A CN107961329 A CN 107961329A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/732—Chaenomeles, e.g. flowering quince
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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Abstract
The invention belongs to field of health care products, specifically provides a kind of hypoglycemic Xuancheng's pawpaw powder, and the active ingredient contained by it is prepared by the extraction of following raw materials in part by weight medicine：20 35 parts of Xuancheng's pawpaw, 15 25 parts of Pollen Astragali Melilotoidis (Pollen Astragali Sinici), 10 20 parts of sesame pollen, 6 10 parts of spina date seed, 8 12 parts of lophatherum gracile, 46 parts of peach kernel, the present invention can be hypoglycemic.
Description
Technical field
The present invention relates to health product technology field, and in particular to a kind of hypoglycemic Xuancheng's pawpaw powder.
Background technology
Xuancheng's pawpaw, which originates in small towns, Jingxian County, the Ningguo such as Shui Dong, Sun Bu of Xuanzhou District, new field, all kings, Xi Kou, Jin Ba, also to be had few
Amount production.Xuancheng's pawpaw is warm-natured, sour-puckery flavor, there is the diseases such as relaxing tendons and activating collaterals, wind-dispelling arthritis with fixed pain caused by dampness.Ancient medicine scholar Tao Hongjing, Su Song, Li Shi
Treasure has higher rating.《Compendium of Materia Medica》Carry：" pawpaw has it everywhere, and Xuancheng person is optimal ", therefore have the title of Xuancheng's pawpaw.Xuanzhou District
The Xuancheng's pawpaw of plantation, existing more than 1500 years history, has been set in period " tribute " early in the Northern and Southern Dynasties.
Diabetes are one group of metabolic diseases characterized by hyperglycaemia.Hyperglycaemia be due to then defect of insulin secretion or
Its biological agent is damaged, or both have concurrently and cause.Long-standing hyperglycaemia during diabetes, causes various tissues, particularly eye,
Kidney, heart, blood vessel, the chronic lesion of nerve, dysfunction.For this reason, it is bursting to develop more safely and effectively Hyperglycemic health cares
Product meet the needs of health care.
The content of the invention
To solve the above-mentioned problems, it is an object of the invention to provide a kind of hypoglycemic Xuancheng's pawpaw powder.In order to reach this
A purpose, adopts the following technical scheme that：
Technical solution：A kind of hypoglycemic Xuancheng's pawpaw powder, the active ingredient contained by it are extracted by following raw materials in part by weight medicine
It is prepared：20-35 parts of Xuancheng's pawpaw, 15-25 parts of Pollen Astragali Melilotoidis (Pollen Astragali Sinici), 10-20 parts of sesame pollen, 6-10 parts of spina date seed, lophatherum gracile
8-12 parts, 4-6 parts of peach kernel.
The hypoglycemic Xuancheng's pawpaw powder, the active ingredient contained by it are prepared by the extraction of following raw materials in part by weight medicine：
28 parts of Xuancheng's pawpaw, 20 parts of Pollen Astragali Melilotoidis (Pollen Astragali Sinici), 15 parts of sesame pollen, 8 parts of spina date seed, 10 parts of lophatherum gracile, 5 parts of peach kernel.
The hypoglycemic Xuancheng's pawpaw powder, formulation is pulvis.
The hypoglycemic Xuancheng's pawpaw powder, preparation process are：Above-mentioned raw materials are taken, are crushed, cross 80 mesh sieves, packing, up to declaring
Papaya powder.
Application of the hypoglycemic Xuancheng's pawpaw powder in health-caring product capable of reducing blood sugar is prepared.
Beneficial effect：Xuancheng's pawpaw contains 19 kinds of amino acid, 18 kinds of mine trace elements, and vitamin C, together
When also containing saponin, flavones, malic acid, oleanolic acid, citric acid, citric acid, tartaric acid, ascorbic acid, fumaric acid, tan
Matter etc., containing catalase, phenol oxidase, oxidizing ferment, especially rich in hepatocuprein (SOD) and oleanolic acid.Its
The content of SOD is impayable in all fruit in the world, and it is international single that the content of one gram of Xuancheng's pawpaw fresh fruit SOD is up to 3227
Position.SOD is the core substance of modern beauty beauty treatment product, can effectively eliminate superfluous free radical in vivo, promote body cell more
Newly.Oleanolic acid has broad-spectrum antibacterial action, has the effects such as protect liver drop enzyme, promoting immunity, anti-inflammatory, reducing blood lipid blood glucose.Fingered citron is used
In stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavilty feeling of fullness, deficiency of food vomiting, coughing with a lot of sputum.Pollen of Semen Fagopyri Esculenti can promote the development of immune organ；
Prevent infringement of the immunodepressant to immune organ；Accelerate the generation of antibody and delay the disappearance of antibody；Promote T lymphocytes and
The increase of macrophage, and the phagocytic activity of macrophage can be improved, so as to improve the immune function of body comprehensively.Chinese milk vetch
(scientific name：Astragalus sinicus L.) it is pulse family, astragalus category biennial herb plant, multi-branched of crawling, height is up to 30 lis
Rice, imparipinnate leaf, petiole are short compared with rachis.Stipule is from life, leaflet obovate or ellipse, apex blunt circle or nick, base portion
Wide wedge shape, above it is near hairless, below scattered white pubescence, raceme, it is in umbrella shape to have flower；Total bennet axillary, bract triangular shape
Avette, bennet is short；Calyx mitriform, calyx tooth lanceolar, corolla aubergine or orange-yellow, vexil obovate, limb oval, pod
Wire oval, seed kidney shape, Chestnut, blooms the 2-6 months, 3-7 month results.Spina date seed is sweet in flavor, sour, mild-natured.Conscience can be nourished,
Calm the nerves, arrest sweating.Lophatherum gracile (Classification system：Lophatherum gracile) it is grass family, lophatherum gracile category perennial herb is planted
Thing, root-like stock.It can be expanded for spindle-like meat root tuber, yellow-white in the middle part of fibrous root.Leaf lanceolar, panicle；Caryopsis ellipse.
It is born in the dark and damp place of hillside hayashishita.It is distributed in each provinces and regions on the south the Changjiang river.Root is medicinal, there is refrigerant, antipyretic, diuresis and the effect hastened parturition；It is main
Control：In the heart disease heat, cough with dyspnea, haematemesis, heat toxin wind, only quench one's thirst, press borax poison, dissolving phlegm, control it is fanatical unhappiness, apoplectic aphasia not
Language, pain intermittent headache, stop palpitate with fear, pestilence fan is vexed, kills small worm, except the slow spleen of heat.It can make herbage again.Peach kernel is rosaceous plant peach Prunus
The dry mature seed of persica (L.) Batsch or mountain peach Prunus davidiana (Carr.) Franch..Fruit maturation
After harvest, remove pulp and nucleocapsid, take out seed, dry.Generally cultivate all parts of the country.With promoting blood circulation, relax bowel, only
The effect of cloperastine is breathed heavily.For closed dysmenorrhea, lump in the abdomen lump in the abdomen lump in the abdomen, lung carbuncle acute appendicitis, injury from falling down, dry constipation of intestines, cough and asthma.The present invention
Xuancheng's pawpaw, Pollen Astragali Melilotoidis (Pollen Astragali Sinici), lophatherum gracile are monarch drug in a prescription, and spina date seed, sesame pollen are ministerial drug, and peach kernel is adjuvant, full side's phase interworking
5, treat diabetes positive effect.
Embodiment
Form by the following examples, is described in further detail the above of the present invention again, but should not be by this
The scope for being interpreted as the above-mentioned theme of the present invention is only limitted to following example, and all technologies for being realized based on the above of the present invention are equal
Belong to the scope of the present invention.
Embodiment 1：Take 20 parts of Xuancheng's pawpaw, 25 parts of Pollen Astragali Melilotoidis (Pollen Astragali Sinici), 10 parts of sesame pollen, 10 parts of spina date seed, lophatherum gracile 8
Part, 6 parts of peach kernel, preparation process are：Above-mentioned raw materials are taken, are crushed, cross 80 mesh sieves, packing, up to Xuancheng's pawpaw powder.
Embodiment 2：Take 35 parts of Xuancheng's pawpaw, 15 parts of Pollen Astragali Melilotoidis (Pollen Astragali Sinici), 20 parts of sesame pollen, 6 parts of spina date seed, lophatherum gracile 12
Part, 4 parts of peach kernel, preparation process are：Above-mentioned raw materials are taken, are crushed, cross 80 mesh sieves, packing, up to Xuancheng's pawpaw powder.
Embodiment 3：Take 28 parts of Xuancheng's pawpaw, 20 parts of Pollen Astragali Melilotoidis (Pollen Astragali Sinici), 15 parts of sesame pollen, 8 parts of spina date seed, lophatherum gracile 10
Part, 5 parts of peach kernel, preparation process are：Above-mentioned raw materials are taken, are crushed, cross 80 mesh sieves, packing, up to Xuancheng's pawpaw powder.
Embodiment 4：Influence of the present invention to rat model of type 2 diabetes mellitus
1st, animal packet
Healthy Wistar rats (SPF grades), male, weight 180-220g (are carried by Medical University Of Anhui's Experimental Animal Center
For), free water feed is randomly divided into Normal group and modeling group, and modeling group establishes model, modeling success as follows
Model group animal is randomly divided into model control group, positive drug gliclazide group, high, normal, basic group, Xuancheng's pawpaw pair of the invention again afterwards
According to group, Xuancheng's pawpaw control group only uses Xuancheng's pawpaw, according to the form below successive administration 1 week.
Administration time and dosage are shown in Table 1：
The effect experiment animal packet of the present invention of table 1
| Group | Number of animals (only) | Dosage (mg/kgBW) |
| Normal group | 12 | |
| Model control group | 12 | |
| Xuancheng's pawpaw control group | 12 | 0.4 |
| Positive drug group | 12 | 35.5 |
| Low dose group | 12 | 0.1 |
| Middle dose group | 12 | 0.2 |
| High dose group | 12 | 0.4 |
2nd, prepared by rat model
The daily gavage distilled water of normal rats, the high daily morning and evening gavage self-control Fat Emulsion (1ml/ of fat group rat
100gBW).After continuous gavage Fat Emulsion 2 weeks, animal fasting for solids but not liquids 24h, 10 tail vein injection physiology salts of blank control group
Water, equal tail vein injection 30mg/kgBW Streptozotocins (hereinafter abbreviated as STZ) solution (prepared before use) of remaining rat.Give
After medicine 48h, fasting for solids but not liquids 12h, eyeball rear vein beard takes blood when 3 is small, empty according to the time-and-motion study of blood sugar detection kit
Abdomen blood glucose value, METHOD FOR CONTINUOUS DETERMINATION 3 times, fasting blood sugar >=16.7mmol/L for modeling success rat.
3rd, the measure of blood glucose
After the last administration, animal fasting for solids but not liquids 12h, eyeball rear vein beard take blood, are surveyed respectively according to the method for kit
Determine blood glucose value.Using SPSS13.0 statistical softwares, analyze and compare the situation of change of each group blood glucose value.
4th, influence of the present invention to rat model of type 2 diabetes mellitus blood glucose
Experimental result is shown in Table 2, and as known from Table 2, after injecting STZ, rat blood sugar rises, and fasting blood sugar after 72h >=
16.7mmol/L, illustrates diabetes model success.After administration, positive drug group, the present invention is high, neutralizes the blood glucose value of low dose group
Compared with model group blood glucose value, there is significant difference (P<0.01).
The T of blood glucose and blood glucose after administration examines display before each group administration, and positive drug group, present invention height, neutralize low dosage
The front and rear blood glucose value of group administration compares, and has significant difference (P<0.01).Result above shows that the present invention can reduce experiment
The blood glucose of property diabetes B rat.
2 experimental result of table
| Group | Number of animals (only) | Blood glucose value before administration | Blood glucose value after administration |
| Normal group | 10 | 5.12±0.48 | 5.60±1.73 |
| Model control group | 9 | 13.87±2.41 | 37.87±5.93 |
| Xuancheng's pawpaw control group | 10 | 31.47±2.18 | 31.54±2.89 |
| Positive drug group | 9 | 32.87±2.62 | 18.90±2.12**△△ |
| Low dose group | 8 | 32.89±2.32 | 22.57±2.72**△△ |
| Middle dose group | 10 | 34.79±1.41 | 17.80±2.42**△△ |
| High dose group | 9 | 35.65±2.71 | 17.40±3.31**△△ |
*p<0.05vs model group * * p<0.01vs model groups△p<Before 0.05vs is with group administration△△p<0.01vs is same to organize administration
Before
Conclusion：The present invention can significantly reduce the blood glucose of diabetes B animal model, can be used for preparing antidiabetic
Thing.
Claims (5)
1. a kind of hypoglycemic Xuancheng's pawpaw powder, it is characterised in that the active ingredient contained by it is extracted by following raw materials in part by weight medicine
It is prepared：20-35 parts of Xuancheng's pawpaw, 15-25 parts of Pollen Astragali Melilotoidis (Pollen Astragali Sinici), 10-20 parts of sesame pollen, 6-10 parts of spina date seed, lophatherum gracile
8-12 parts, 4-6 parts of peach kernel.
2. hypoglycemic Xuancheng's pawpaw powder as claimed in claim 1, it is characterised in that the active ingredient contained by it is by following parts by weight
Bulk pharmaceutical chemicals extraction is prepared：28 parts of Xuancheng's pawpaw, 20 parts of Pollen Astragali Melilotoidis (Pollen Astragali Sinici), 15 parts of sesame pollen, 8 parts of spina date seed, lophatherum gracile 10
Part, 5 parts of peach kernel.
3. hypoglycemic Xuancheng's pawpaw powder as claimed in claim 1, it is characterised in that formulation is pulvis.
4. hypoglycemic Xuancheng's pawpaw powder as claimed in claim 1, it is characterised in that preparation process is：Above-mentioned raw materials are taken, are crushed,
80 mesh sieves are crossed, are dispensed, up to Xuancheng's pawpaw powder.
5. application of the hypoglycemic Xuancheng's pawpaw powder in health-caring product capable of reducing blood sugar is prepared according to claim 1.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711412697.3A CN107961329A (en) | 2017-12-24 | 2017-12-24 | A kind of hypoglycemic Xuancheng's pawpaw powder |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711412697.3A CN107961329A (en) | 2017-12-24 | 2017-12-24 | A kind of hypoglycemic Xuancheng's pawpaw powder |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104146240A (en) * | 2013-12-17 | 2014-11-19 | 河南茗轩食品科技有限公司 | Health-care composition for lowering blood glucose and lipid and preparation method thereof |
| CN105029559A (en) * | 2015-06-17 | 2015-11-11 | 蚌埠市福淋乳业有限公司 | Ginseng fruit and chaenomeles speciosa blended fruit-vegetable juice and preparation method thereof |
| CN107125504A (en) * | 2017-05-22 | 2017-09-05 | 宣城华科宣木瓜生物科技有限公司 | A kind of hypoglycemic Xuancheng's pawpaw health drink and preparation method thereof |
-
2017
- 2017-12-24 CN CN201711412697.3A patent/CN107961329A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104146240A (en) * | 2013-12-17 | 2014-11-19 | 河南茗轩食品科技有限公司 | Health-care composition for lowering blood glucose and lipid and preparation method thereof |
| CN105029559A (en) * | 2015-06-17 | 2015-11-11 | 蚌埠市福淋乳业有限公司 | Ginseng fruit and chaenomeles speciosa blended fruit-vegetable juice and preparation method thereof |
| CN107125504A (en) * | 2017-05-22 | 2017-09-05 | 宣城华科宣木瓜生物科技有限公司 | A kind of hypoglycemic Xuancheng's pawpaw health drink and preparation method thereof |
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Effective date of registration: 20181210 Address after: 242000 Pioneering Road 23-3-2, Xuancheng Economic and Technological Development Zone, Xuancheng City, Anhui Province Applicant after: XUANCHENG HUAKE XUANMUGUA BIOTECHNOLOGY CO., LTD. Address before: 242000 Dangui Apartment, Renmin Road, Ningguo City, Xuancheng City, Anhui Province, 2 West 112 Storage, West 112, West 212 Applicant before: Ningguo balanced Health Management Company Limited |
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