CN107952012A - 一种防治球虫病的中药组合物及其制备方法 - Google Patents

一种防治球虫病的中药组合物及其制备方法 Download PDF

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CN107952012A
CN107952012A CN201711498305.XA CN201711498305A CN107952012A CN 107952012 A CN107952012 A CN 107952012A CN 201711498305 A CN201711498305 A CN 201711498305A CN 107952012 A CN107952012 A CN 107952012A
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changshan
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臧德杰
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Green Tech (tianjin) Biological Technology Co Ltd
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Abstract

本发明涉及一种防治球虫病的中药组合物及其制备方法，其组成成分及其重量份数分别为：葛根5‑7份、苦参6‑8份、贯众5‑10份、仙鹤草5‑7份、蜀漆5‑10份、石榴皮6‑8份、青蒿9‑11份、黄连5‑7份、常山2‑4份、秦皮3‑5份、仙鹤草1‑3份、白头翁1‑3份、肉豆蔻1‑3份、苦豆子2‑4份、白茅根1‑3份、甘草1‑3份。本中药组合物依据中药理论，结合现代中药开发技术研制开发，保留了中药方剂辨证论治的组合效应，可制成颗粒剂；并运用现代科技手段对其中大部分药材的有效成分进行定量、半定量检测，经临床验证疗效确切，为无公害无药残的绿色兽药。

Description

一种防治球虫病的中药组合物及其制备方法
技术领域
本发明属于中药领域，尤其是一种防治球虫病的中药组合物及其制备方法。
背景技术
在农业产业调整过程中，畜牧业比重逐渐增大，疫病成为制约畜牧业发展的重要因素。我国兽药产品发展很慢，独创的产品几乎没有。在畜禽产品特别是肉鸡出口中，发达国家尤其是欧盟将疫病和药残筑起了技术壁垒，又称绿色壁垒，尽管欧盟对中国开放肉类市场，但至今还没有中国的肉品在欧盟上市。为了解决一些化学的致残、致畸等问题，人们将目光转向了中草药。国内目前的兽药品种较多，但兽用中草药(包括制剂)质量标准一直是对有效成分的定性而不是定量，且工艺粗糙，质量不稳定，疗效不确切，不利于中兽药的发展。
发明内容
本发明的目的之一是克服现有技术的不足，提供一种抗球虫、止血补血、抗菌消炎中药组合物。
本发明的另一个目的是提供上述一种防治球虫病的中药组合物的制备方法。
本发明解决其技术问题是通过以下技术方案实现的：
一种防治球虫病的中药组合物，组成成分及其重量份数分别为：
葛根5-7份、苦参6-8份、贯众5-10份、仙鹤草5-7份、蜀漆5-10份、石榴皮6-8份、青蒿9-11份、黄连5-7份、常山2-4份、秦皮3-5份、仙鹤草1-3份、白头翁1-3份、肉豆蔻1-3份、苦豆子2-4份、白茅根1-3份、甘草1-3份。
而且，一种防治球虫病的中药组合物的制备方法，其步骤是：
(1)将青蒿采用石油醚提取有效成分，回流提取温度是60-90℃，得到青蒿石油醚提取液，并采用冷疑回收石油醚，得到青蒿提取液待用，收集青蒿药渣；
(2)将常山采用无水乙醇回流提取有效成分，回流温度为60-80℃，得到常山乙醇提取液，并采用冷疑回收乙醇，得到常山提取液待用，收集常山药渣；
(3)分别称取葛根、苦参、贯众、仙鹤草、蜀漆、黄连、常山、石榴皮、秦皮、仙鹤草、白头翁、肉豆蔻、苦豆子、白茅根、甘草并混合，然后将提取将草提取液及常山提取液所产生的药渣加入，搅拌均匀后进行2次水提，合并水提后的提取液，第一次2小时，第二次水提1小时；
(4)将提取液减压浓缩、干燥，得到干浸膏；
(5)在干浸膏中加入待用的青蒿提取液及常山提取液，经制粒、干燥、整粒，即得到本中药组合物的颗粒剂成品。
本发明的优点和有益效果为：
1.本中药组合物依据中药理论，结合现代中药开发技术研制开发，保留了中药方剂辨证论治的组合效应，可制成颗粒剂；并运用现代科技手段对其中大部分药材的有效成分进行定量、半定量检测，经临床验证疗效确切，为无公害无药残的绿色兽药。
2.本中药组合物以君药为主要研究对象，创新提取工艺，充分提取主要有效成分，按照兽药GMP标准，以中兽医经验为基础，采用现代化的检测手段和现代化的制药设备研制推广疗效好、无公害、无残留、服用方便的中兽药。
3.本中药组合物以君药的主要成分造颗粒，完善质量标准，改进工艺，加强质量控制过程，筛选地道药材，稳定产品质量，成本低廉，抗球虫、止血补血、抗菌消炎疗效好，具有较强的产品市场竞争能力。
具体实施方式
下面通过具体实施例对本发明作进一步详述，以下实施例只是描述性的，不是限定性的，不能以此限定本发明的保护范围。
实施例1：
一种防治球虫病的中药组合物，其组成成分及其重量分别为：
葛根5份、苦参6份、贯众5份、仙鹤草5份、蜀漆5份、石榴皮6份、青蒿9份、黄连5份、常山2份、秦皮3份、仙鹤草1份、白头翁1份、肉豆蔻1份、苦豆子2份、白茅根1份、甘草1份。
一种防治球虫病的中药组合物的制备方法，制备方法的步骤是：
(1)将青蒿采用石油醚提取有效成分，回流提取温度是60-90℃，得到青蒿石油醚提取液，并采用冷疑回收石油醚，得到青蒿提取液待用，收集青蒿药渣；
(2)将常山采用无水乙醇回流提取有效成分，回流温度为60-80℃，得到常山乙醇提取液，并采用冷疑回收乙醇，得到常山提取液待用，收集常山药渣；
(3)分别称取葛根、苦参、贯众、仙鹤草、蜀漆、黄连、常山、石榴皮、秦皮、仙鹤草、白头翁、肉豆蔻、苦豆子、白茅根、甘草并混合，然后将提取将草提取液及常山提取液所产生的药渣加入，搅拌均匀后进行2次水提，合并水提后的提取液，第一次2小时，第二次水提1小时；
(4)将提取液减压浓缩、干燥，得到干浸膏；
(5)在干浸膏中加入待用的青蒿提取液及常山提取液，经制粒、干燥、整粒，即得到本中药组合物的颗粒剂成品。
本发明中，青蒿的有效成分——青蒿素≥0.6％(成品总重量)，常山的有效成分——常山酮≥0.4mg/g(成品总重量)。
实施例2：
一种防治球虫病的中药组合物，其组成成分及其重量分别为：
葛根6份、苦参7份、贯众8份、仙鹤草6份、蜀漆8份、石榴皮7份、青蒿10份、黄连6份、常山3份、秦皮4份、仙鹤草2份、白头翁2份、肉豆蔻2份、苦豆子3份、白茅根3份、甘草2份。
其制备方法同于实施例1。
实施例3：
一种防治球虫病的中药组合物，其组成成分及其重量分别为：
葛根7份、苦参8份、贯众10份、仙鹤草7份、蜀漆10份、石榴皮8份、青蒿11份、黄连7份、常山4份、秦皮5份、仙鹤草3份、白头翁3份、肉豆蔻3份、苦豆子4份、白茅根3份、甘草3份。
其制备方法同于实施例1。
制剂稳定性试验

Claims (3)

1.一种防治球虫病的中药组合物，其特征在于：组成成分及其重量份数分别为：
葛根5-7份、苦参6-8份、贯众5-10份、仙鹤草5-7份、蜀漆5-10份、石榴皮6-8份、青蒿9-11份、黄连5-7份、常山2-4份、秦皮3-5份、仙鹤草1-3份、白头翁1-3份、肉豆蔻1-3份、苦豆子2-4份、白茅根1-3份、甘草1-3份。
2.一种如权利要求1所述的一种防治球虫病的中药组合物的制备方法，其特征在于：其步骤是：
(1)将青蒿采用石油醚提取有效成分，回流提取温度是60-90℃，得到青蒿石油醚提取液，并采用冷疑回收石油醚，得到青蒿提取液待用，收集青蒿药渣；
(2)将常山采用无水乙醇回流提取有效成分，回流温度为60-80℃，得到常山乙醇提取液，并采用冷疑回收乙醇，得到常山提取液待用，收集常山药渣；
(3)分别称取葛根、苦参、贯众、仙鹤草、蜀漆、黄连、常山、石榴皮、秦皮、仙鹤草、白头翁、肉豆蔻、苦豆子、白茅根、甘草并混合，然后将提取将草提取液及常山提取液所产生的药渣加入，搅拌均匀后进行2次水提，合并水提后的提取液，第一次2小时，第二次水提1小时；
(4)将提取液减压浓缩、干燥，得到干浸膏；
(5)在干浸膏中加入待用的青蒿提取液及常山提取液，经制粒、干燥、整粒，即得到本中药组合物的颗粒剂成品。
3.一种如权利要求1所述的一种防治球虫病的中药组合物的制备方法，其特征在于：葛根6份、苦参7份、贯众8份、仙鹤草6份、蜀漆8份、石榴皮7份、青蒿10份、黄连6份、常山3份、秦皮4份、仙鹤草2份、白头翁2份、肉豆蔻2份、苦豆子3份、白茅根3份、甘草2份。
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Publication number Priority date Publication date Assignee Title
CN109364230A (zh) * 2018-12-18 2019-02-22 丹东瑞丰动物药业有限责任公司 一种治疗鸡球虫病的中药及其制备方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109364230A (zh) * 2018-12-18 2019-02-22 丹东瑞丰动物药业有限责任公司 一种治疗鸡球虫病的中药及其制备方法

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