CN107951810A - A kind of nti-freckle lipid gel, preparation method and applications containing birds nest extract - Google Patents
A kind of nti-freckle lipid gel, preparation method and applications containing birds nest extract Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The invention discloses a kind of nti-freckle lipid gel, preparation method and applications containing birds nest extract.The nti-freckle lipid gel containing birds nest extract includes the component of following parts by weight：30~50 parts of 0.5~3.5 part of birds nest extract, 1.2~2.8 parts of Angelica Dahurica extract, 0.2~4 part of Honegsukle flower P.E, 2~6 parts of camomile extract, phosphatidase 1 .6~5 part, 8~16 parts of cholesterol, 7~12 parts of liquid fatty, 0.5~1.5 part of emulsifying agent, 0.1~1.5 part of thickener and deionized water.The present invention is rich in nti-freckle active ingredient, can suppress the generation of tyrosinase activity and melanin, be conducive to lighten the stain, whitening spot-removing, and gently non-stimulated to skin；Active ingredient is contained using liposome vectors, improves its permeability and absorbability to skin, hence it is evident that lift the freckle effect of active ingredient.
Description
Technical field
The present invention relates to skin care field, and in particular to a kind of nti-freckle lipid gel, preparation method containing birds nest extract
And its application.
Background technology
Skin is the important component of human body, when skin metabolism weaken, poor blood circulation, when malnutritive, skin
It can become gloomy, easily produce wrinkle and color spot；Ultraviolet is also the major reason that skin produces color spot, in irradiation ultraviolet
When, skin can produce a large amount of pigments to protect skin in basalis, therefore, often exposed not only to accelerate skin under strong sunlight
Skin aging, also results in pigment deposition, causes blackspot, freckle.
At present, as people understand melanin formation mechenism in depth, and the depth to natural extract nti-freckle component
Enter research, find efficiently and to human body is without side-effects or the natural extract nti-freckle preparation of Small side effects becomes and grinds both at home and abroad
Study carefully hot spot.Natural extract pharmacological property is stablized, and effect is lasting, and gentle to skin, and stimulation is small, and a new side is provided for mankind's nti-freckle
Method.
The content of the invention
It is an object of the invention to overcome the deficiencies of the prior art and provide a kind of nti-freckle lipid containing birds nest extract to coagulate
Glue.
It is another object of the present invention to provide a kind of preparation method of the nti-freckle lipid gel containing birds nest extract.
It is another object of the present invention to provide a kind of application of the nti-freckle lipid gel containing birds nest extract
To achieve the above object, the technical solution that the present invention takes is as follows：
A kind of nti-freckle lipid gel containing birds nest extract, includes the component of following parts by weight：Birds nest extract 0.5~
3.5 parts, 1.2~2.8 parts of Angelica Dahurica extract, 0.2~4 part of Honegsukle flower P.E, 2~6 parts of camomile extract, phosphatidase 1 .6~5
Part, 8~16 parts of cholesterol, 7~12 parts of liquid fatty, 0.5~1.5 part of emulsifying agent, 0.1~1.5 part of thickener and deionized water
30~50 parts.
Birds nest extract has effects that beautifying face and moistering lotion in above-mentioned technical proposal, reduces the pigment deposition of skin, and enhancing is dispelled
Spot effect；Angelica Dahurica extract, Honegsukle flower P.E, camomile extract can suppress the life of tyrosinase activity and melanin
Into, be conducive to lighten the stain, whitening spot-removing, and it is gently non-stimulated to skin.
The present invention extracts Angelica Dahurica extract, birds nest extract, Honegsukle flower P.E and chamomile using liposome vectors
Thing is contained, and improves its permeability and absorbability to skin, hence it is evident that lift the freckle effect of active ingredient.
As the preferred embodiment of the nti-freckle lipid gel of the present invention containing birds nest extract, following weight is included
The component of number：1~2.5 part of birds nest extract, 1.5~2.4 parts of Angelica Dahurica extract, 2~3.2 parts of Honegsukle flower P.E, ocean are sweet
4~5 parts of chrysanthemum extract, phosphatidase 1 .6~5 part, 8~16 parts of cholesterol, 7~12 parts of liquid fatty, 0.5~1.5 part of emulsifying agent, increasing
Thick dose 0.1~1.5 part and 30~50 parts of deionized water.
As the preferred embodiment of the nti-freckle lipid gel of the present invention containing birds nest extract, following weight is included
The component of number：1.8 parts of birds nest extract, 2 parts of Angelica Dahurica extract, 2.5 parts of Honegsukle flower P.E, 4.6 parts of camomile extract,
Phosphatidase 1 .6~5 part, 8~16 parts of cholesterol, 7~12 parts of liquid fatty, 0.5~1.5 part of emulsifying agent, 0.1~1.5 part of thickener
With 30~50 parts of deionized water.
As the preferred embodiment of the nti-freckle lipid gel of the present invention containing birds nest extract, the phosphatide is big
At least one of beans lecithin, egg yolk lecithin, hydrolecithin, phosphatidyl choline, phosphatidyl-ethanolamine.
As the preferred embodiment of the nti-freckle lipid gel of the present invention containing birds nest extract, the liquid fatty
For at least one of jojoba oil, avocado oil, olive oil, coconut oil.
As the preferred embodiment of the nti-freckle lipid gel of the present invention containing birds nest extract, the thickener is
Cellulose, carragheen, pectin or carbomer.
As the preferred embodiment of the nti-freckle lipid gel of the present invention containing birds nest extract, the emulsifying agent is
At least one of Tween-80, Tween-60, stearic acid, glyceryl monostearate.
The present invention also provides the preparation method of the above-mentioned nti-freckle lipid gel containing birds nest extract, comprise the following steps：
(1) each component raw material is weighed in proportion, is sieved；
(2) thickener is dissolved in deionized water, be sufficiently stirred, obtain water phase；
(3) by birds nest extract, Angelica Dahurica extract, Honegsukle flower P.E, camomile extract, phosphatide, cholesterol, liquid
Lipid and emulsifying agent press 1:30~45 mass ratio is dissolved in chloroform soln, is sufficiently stirred to obtain oil at 75~95 DEG C
Phase；
(4) oil phase is placed in container, in decompression rotary evaporation chloroform, phosphatide is formed film in wall, then
Phosphate buffer solution is added, aquation is overnight, formation liposome turbid liquor, and ultrasound under ice bath, obtains liposome；
(5) the water phase for obtaining liposome addition step (2), is stirred continuously at 70~85 DEG C, stirs evenly, be cooled to
Room temperature, obtains the nti-freckle lipid gel containing birds nest extract.
As the preferred embodiment of the preparation method of the nti-freckle lipid gel of the present invention containing birds nest extract, institute
State in step (1), birds nest extract, Angelica Dahurica extract, Honegsukle flower P.E and camomile extract are crossed into 200 mesh sieves.
Sieving processing is carried out to each extract, finer and smoother spot removal and skin care composition can be obtained, preferably release activity
Component, freckle effect is more preferably.
The present invention also provides above-mentioned application of the nti-freckle lipid gel in cosmetics containing birds nest extract.
Compared with prior art, the invention has the advantages that：
Birds nest extract has effects that beautifying face and moistering lotion in the nti-freckle lipid gel of the present invention, and the pigment for reducing skin sinks
Product, strengthens freckle effect；Angelica Dahurica extract, Honegsukle flower P.E, camomile extract can suppress tyrosinase activity and black
The generation of pigment, is conducive to lighten the stain, whitening spot-removing, and gently non-stimulated to skin；The root of Dahurain angelica is carried using liposome vectors
Take thing, birds nest extract, Honegsukle flower P.E and camomile extract to be contained, improve its permeability and suction to skin
The property received, hence it is evident that lift the freckle effect of active ingredient.
Embodiment
For the object, technical solutions and advantages of the present invention are better described, below in conjunction with specific embodiment to the present invention
Further illustrate.It will be appreciated by those skilled in the art that specific embodiment described herein is only to explain the present invention, not
For limiting the present invention.
Test method used in following embodiments is conventional method unless otherwise specified；Institute in following embodiments
The material that uses, reagent etc., are commercially available unless otherwise specified.
Birds nest extract, Angelica Dahurica extract, Honegsukle flower P.E and the camomile extract of the present invention is excellent large purchased from Xi'an
Bio tech ltd.
Embodiment 1
A kind of embodiment of nti-freckle lipid gel of the invention containing birds nest extract, the present embodiment include following parts by weight
Component：1.8 parts of birds nest extract, 2 parts of Angelica Dahurica extract, 2.5 parts of Honegsukle flower P.E, 4.6 parts of camomile extract, soybean
1 part of lecithin, 2 parts of egg yolk lecithin, 12 parts of cholesterol, 3 parts of jojoba oil, 6 parts of avocado oil, 0.3 part of Tween-80, stearic acid
40 parts of 0.3 part, 0.3 part of glyceryl monostearate, 0.8 part of carragheen and deionized water.
The preparation method of the nti-freckle lipid gel containing birds nest extract described in embodiment is：
(1) each component raw material is weighed in proportion, and birds nest extract, Angelica Dahurica extract, Honegsukle flower P.E, chamomile carry
Thing is taken to cross 200 mesh sieves；
(2) carragheen is dissolved in deionized water, be sufficiently stirred, obtain water phase；
(3) by birds nest extract, Angelica Dahurica extract, Honegsukle flower P.E, camomile extract, soybean lecithin, yolk
Lecithin, cholesterol, jojoba oil, avocado oil, Tween-80, stearic acid, glyceryl monostearate press 1:42 mass ratio is dissolved in
In chloroform soln, it is sufficiently stirred to obtain oil phase at 90 DEG C；
(4) oil phase is placed in container, in decompression rotary evaporation chloroform, phosphatide is formed film in wall, then
Phosphate buffer solution is added, aquation is overnight, formation liposome turbid liquor, and ultrasound under ice bath, obtains liposome；
(5) the water phase for obtaining liposome addition step (2), is stirred continuously at 80 DEG C, stirs evenly, be cooled to room
Temperature, obtains the nti-freckle lipid gel containing birds nest extract.
Embodiment 2
A kind of embodiment of nti-freckle lipid gel of the invention containing birds nest extract, the present embodiment include following parts by weight
Component：Include the component of following parts by weight：2.5 parts of birds nest extract, 2.4 parts of Angelica Dahurica extract, Honegsukle flower P.E 2
It is part, 4 parts of camomile extract, 1 part of lecithin of hydrogenation, 1 part of phosphatidyl choline, 12 parts of cholesterol, olive oil 4,5 parts of coconut oil, hard
45 parts of 0.3 part of resin acid, 0.9 part of glyceryl monostearate, 1.2 parts of pectin and deionized water.
The preparation method of the nti-freckle lipid gel containing birds nest extract described in embodiment is：
(1) each component raw material is weighed in proportion, and birds nest extract, Angelica Dahurica extract, Honegsukle flower P.E, chamomile carry
Thing is taken to cross 200 mesh sieves；
(2) pectin is dissolved in deionized water, be sufficiently stirred, obtain water phase；
(3) by birds nest extract, Angelica Dahurica extract, Honegsukle flower P.E, camomile extract, hydrogenation lecithin, phosphatidyl
Choline, cholesterol, olive oil, coconut oil, stearic acid, glyceryl monostearate press 1:30 mass ratio is dissolved in chloroform soln
In, it is sufficiently stirred to obtain oil phase at 90 DEG C；
(4) oil phase is placed in container, in decompression rotary evaporation chloroform, phosphatide is formed film in wall, then
Phosphate buffer solution is added, aquation is overnight, formation liposome turbid liquor, and ultrasound under ice bath, obtains liposome；
(5) the water phase for obtaining liposome addition step (2), is stirred continuously at 80 DEG C, stirs evenly, be cooled to room
Temperature, obtains the nti-freckle lipid gel containing birds nest extract.
Embodiment 3
A kind of embodiment of nti-freckle lipid gel of the invention containing birds nest extract, the present embodiment include following parts by weight
Component：Include the component of following parts by weight：1 part of birds nest extract, 1.5 parts of Angelica Dahurica extract, Honegsukle flower P.E 3.2
Part, 5 parts of camomile extract, 4 parts of phosphatidyl-ethanolamine, 10 parts of cholesterol, 8 parts of jojoba oil, 0.8 part of stearic acid, carbomer
0.5 part and 35 parts of deionized water.
The preparation method of the nti-freckle lipid gel containing birds nest extract described in embodiment is：
(1) each component raw material is weighed in proportion, and birds nest extract, Angelica Dahurica extract, Honegsukle flower P.E, chamomile carry
Thing is taken to cross 200 mesh sieves；
(2) carbomer is dissolved in deionized water, be sufficiently stirred, obtain water phase；
(3) by birds nest extract, Angelica Dahurica extract, Honegsukle flower P.E, camomile extract, phosphatidyl-ethanolamine, courage
Sterol, jojoba oil and stearic acid press 1:35 mass ratio is dissolved in chloroform soln, is sufficiently stirred to obtain oil at 80 DEG C
Phase；
(4) oil phase is placed in container, in decompression rotary evaporation chloroform, phosphatide is formed film in wall, then
Phosphate buffer solution is added, aquation is overnight, formation liposome turbid liquor, and ultrasound under ice bath, obtains liposome；
(5) the water phase for obtaining liposome addition step (2), is stirred continuously at 80 DEG C, stirs evenly, be cooled to room
Temperature, obtains the nti-freckle lipid gel containing birds nest extract.
Embodiment 4
A kind of embodiment of nti-freckle lipid gel of the invention containing birds nest extract, the present embodiment include following parts by weight
Component：0.5 part of birds nest extract, 1.2 parts of Angelica Dahurica extract, 4 parts of Honegsukle flower P.E, 6 parts of camomile extract, soybean ovum
50 parts of phosphatidase 5 part, 8 parts of cholesterol, 12 parts of olive oil, 0.5 part of glyceryl monostearate, 1.5 parts of carbomer and deionized water.
The preparation method of the nti-freckle lipid gel containing birds nest extract described in embodiment is：
(1) each component raw material is weighed in proportion, and birds nest extract, Angelica Dahurica extract, Honegsukle flower P.E, chamomile carry
Thing is taken to cross 200 mesh sieves；
(2) carbomer is dissolved in deionized water, be sufficiently stirred, obtain water phase；
(3) it is birds nest extract, Angelica Dahurica extract, Honegsukle flower P.E, camomile extract, soybean lecithin, courage is solid
Alcohol, olive oil and glyceryl monostearate press 1:30 mass ratio is dissolved in chloroform soln, is sufficiently stirred at 95 DEG C
To oil phase；
(4) oil phase is placed in container, in decompression rotary evaporation chloroform, phosphatide is formed film in wall, then
Phosphate buffer solution is added, aquation is overnight, formation liposome turbid liquor, and ultrasound under ice bath, obtains liposome；
(5) the water phase for obtaining liposome addition step (2), is stirred continuously at 70 DEG C, stirs evenly, be cooled to room
Temperature, obtains the nti-freckle lipid gel containing birds nest extract.
Embodiment 5
A kind of embodiment of nti-freckle lipid gel of the invention containing birds nest extract, the present embodiment include following parts by weight
Component：3.5 parts of birds nest extract, 2.8 parts of Angelica Dahurica extract, 0.2 part of Honegsukle flower P.E, 2 parts of camomile extract, yolk
30 parts of 1.6 parts of lecithin, 16 parts of cholesterol, 7 parts of coconut oil, 1.5 parts of Tween-80,0.1 part of cellulose and deionized water.
The preparation method of the nti-freckle lipid gel containing birds nest extract described in embodiment is：
(1) each component raw material is weighed in proportion, and birds nest extract, Angelica Dahurica extract, Honegsukle flower P.E, chamomile carry
Thing is taken to cross 100 mesh sieves；
(2) cellulose is dissolved in deionized water, be sufficiently stirred, obtain water phase；
(3) it is birds nest extract, Angelica Dahurica extract, Honegsukle flower P.E, camomile extract, egg yolk lecithin, courage is solid
Alcohol, coconut oil and Tween-80 press 1:45 mass ratio is dissolved in chloroform soln, is sufficiently stirred to obtain oil phase at 75 DEG C；
(4) oil phase is placed in container, in decompression rotary evaporation chloroform, phosphatide is formed film in wall, then
Phosphate buffer solution is added, aquation is overnight, formation liposome turbid liquor, and ultrasound under ice bath, obtains liposome；
(5) the water phase for obtaining liposome addition step (2), is stirred continuously at 85 DEG C, stirs evenly, be cooled to room
Temperature, obtains the nti-freckle lipid gel containing birds nest extract.
Comparative example 1
This comparative example includes the component of following parts by weight：1.8 parts of birds nest extract, 2 parts of Angelica Dahurica extract, honeysuckle carry
Take 2.5 parts of thing, 4.6 parts of camomile extract, 3 parts of jojoba oil, 6 parts of avocado oil, 0.3 part of Tween-80,0.3 part of stearic acid, sweet
40 parts of oily 0.3 part of monostearate, 0.8 part of carragheen and deionized water.
The preparation method of the spot removal and skin care composition containing birds nest extract described in this comparative example is：
(1) each component raw material is weighed in proportion, and birds nest extract, Angelica Dahurica extract, Honegsukle flower P.E, chamomile carry
Thing is taken to cross 200 mesh sieves；
(2) carragheen is dissolved in deionized water, be sufficiently stirred, obtain water phase；
(3) by birds nest extract, Angelica Dahurica extract, Honegsukle flower P.E, camomile extract, jojoba oil, avocado oil,
Tween-80, stearic acid, glyceryl monostearate press 1:42 mass ratio is dissolved in chloroform soln, is fully stirred at 90 DEG C
Mix to obtain oil phase；
(4) oil phase is placed in container, in decompression rotary evaporation chloroform, the water phase that step (2) obtains is added, 80
It is stirred continuously, stirs evenly at DEG C, be cooled to room temperature, obtains the spot removal and skin care composition.
Nti-freckle lipid gel effect measure containing birds nest extract
(1) permeability experiment
The nti-freckle prepared using the nti-freckle lipid gel containing birds nest extract prepared by embodiment 1 as experimental group, comparative example 1
Skin care compositions carries out permeability experiment as a control group.(the red of Chen Liang are containing breast with reference to pertinent literature for permeability experiment method and step
The technology of preparing of wooden fruit oil nano emulsions and its application study [D] Shanghai Institute Of Technology, 2015.), experimental result such as table 1
It is shown.
Table 1
As shown in Table 1, permeability of the embodiment 1 after liposome entrapment is better than comparative example 1.The result shows that the present invention
Nti-freckle lipid gel is good in the permeability of skin surface, makes it easier to penetrate skin surface, increase nti-freckle active material is worn
Saturating power, the effect of more preferably playing its deep layer whitening spot-removing.
(2) to the suppression of tyrosinase activity
Nti-freckle lipid gel containing birds nest extract prepared by present invention measure embodiment 1~5 is to tyrosinase activity
Inhibiting rate, experimental method with reference to pertinent literature, (with whitening effect appraisement system grind by the strong the black pigment of skin genetic analysis of Wang Bai
[J] chemical engineerings are studied carefully with equipping, 2008, (02):14-18.[2017-09-29].).Prepare each group reaction solution, 37 DEG C of thermostatted waters
Bath, tyrosinase is added in tyrosine solution, and the skin care item solution that measured concentration is 0.5% and 1.0% passes through microplate reader
The absorbance of (MultiskanFC, Thermo) at 475nm, repeats experiment 5 times, suppression of the skin care item to tyrosinase activity
The results are shown in Table 2 for rate.
Table 2
| Concentration | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| 0.5% | 92.8% | 85.7% | 88.5% | 82.5% | 80.8% |
| 1.0% | 97.3% | 91.7% | 93.8% | 89.4% | 88.3% |
Tyrosine is the primary raw material for manufacturing melanocyte, and tyrosinase is then the crucial rate-limiting enzyme that tyrosine is changed into melanocyte,
Therefore generation of the tyrosinase to the black pigment of skin has material impact, and the inhibiting rate to tyrosinase activity is also to weigh skin care
The important evidence of product freckle effect.From table 2 it can be seen that the nti-freckle lipid gel containing birds nest extract prepared by the present invention is to junket
Propylhomoserin enzymatic activity has very strong rejection ability, has good freckle effect.Test result indicates that coagulated by adjusting nti-freckle lipid
The ratio of glue each component, it is different to inhibitory activity against tyrosinase, and wherein the nti-freckle lipid gel of embodiment 1 is to junket ammonia
The stronger rejection ability of phytase activity.
(3) human skin adverse reaction is tested
The volunteer 100 that the age is 16~25 years old is chosen, is randomly divided into 5 groups, every group of each 20 people.Reference《Cosmetics are defended
Raw specification》The related request of " human skin patch " carries out human skin adverse reaction experiment in (2007 editions).Will
Nti-freckle lipid gel containing birds nest extract prepared by the embodiment 1~5 of 0.025g is added on spot examination device, and with non-stimulated glue
Spot examination device is attached to the forearm song side of volunteer by band, is gently pressed with hand and is allowed to uniformly attach on the skin, except despeckle tries device after 24h,
Dermoreaction is observed after 30min, 1h, 2h, 24h respectively, and according to table 3《Skin adverse reaction grade scale table》Record is anti-
Answer result.
Table 3
Table 4
| Grading system | Number of cases | Ratio |
| 0 | 20 | 100% |
| 1 | 0 | 0 |
| 2 | 0 | 0 |
| 3 | 0 | 0 |
| 4 | 0 | 0 |
The skin adverse reaction result for the nti-freckle lipid gel containing birds nest extract that table 4 is prepared for embodiment 1.Embodiment
The skin adverse reaction result of the nti-freckle lipid gel containing birds nest extract prepared by 2~5 is same as Example 1.Experiment knot
Fruit shows that volunteer's result of the test of the embodiment of the present invention 1~5 is feminine gender, and no bad dermoreaction occurs, and shows the present invention
The nti-freckle lipid gel containing birds nest extract prepared is gently non-stimulated, and security is good.
Nti-freckle lipid gel produced by the present invention containing birds nest extract, by adjusting the ratio of the auxiliary material, or addition
The auxiliary material of other cosmetics routine, can also apply in spot-eliminating skin care product skin care item.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than the present invention is protected
The limitation of scope is protected, although being explained in detail with reference to preferred embodiment to the present invention, those of ordinary skill in the art should
Understand, can be to technical scheme technical scheme is modified or replaced equivalently, without departing from the essence of technical solution of the present invention
And scope.
Claims (10)
1. a kind of nti-freckle lipid gel containing birds nest extract, it is characterised in that include the component of following parts by weight：Bird's nest carries
Take 0.5~3.5 part of thing, 1.2~2.8 parts of Angelica Dahurica extract, 0.2~4 part of Honegsukle flower P.E, 2~6 parts of camomile extract,
Phosphatidase 1 .6~5 part, 8~16 parts of cholesterol, 7~12 parts of liquid fatty, 0.5~1.5 part of emulsifying agent, 0.1~1.5 part of thickener
With 30~50 parts of deionized water.
2. the nti-freckle lipid gel according to claim 1 containing birds nest extract, it is characterised in that include following parts by weight
Several components：1~2.5 part of birds nest extract, 1.5~2.4 parts of Angelica Dahurica extract, 2~3.2 parts of Honegsukle flower P.E, chamomile
4~5 parts of extract, phosphatidase 1 .6~5 part, 8~16 parts of cholesterol, 7~12 parts of liquid fatty, 0.5~1.5 part of emulsifying agent, thickening
30~50 parts of 0.1~1.5 part of agent and deionized water.
3. the nti-freckle lipid gel according to claim 1 containing birds nest extract, it is characterised in that include following parts by weight
Several components：1.8 parts of birds nest extract, 2 parts of Angelica Dahurica extract, 2.5 parts of Honegsukle flower P.E, 4.6 parts of camomile extract, phosphorus
1.6~5 parts of fat, 8~16 parts of cholesterol, 7~12 parts of liquid fatty, 0.5~1.5 part of emulsifying agent, 0.1~1.5 part of thickener and
30~50 parts of deionized water.
4. the nti-freckle lipid gel according to claim 1 containing birds nest extract, it is characterised in that the phosphatide is soybean
At least one of lecithin, egg yolk lecithin, hydrolecithin, phosphatidyl choline, phosphatidyl-ethanolamine.
5. the nti-freckle lipid gel according to claim 1 containing birds nest extract, it is characterised in that the liquid fatty is
At least one of jojoba oil, avocado oil, olive oil, coconut oil.
6. according to the nti-freckle lipid gel containing birds nest extract described in claim 1, it is characterised in that the thickener is fiber
Element, carragheen, pectin or carbomer.
7. the nti-freckle lipid gel according to claim 1 containing birds nest extract, it is characterised in that the emulsifying agent is to spit
At least one of temperature -80, Tween-60, stearic acid, glyceryl monostearate.
8. according to the preparation method of nti-freckle lipid gel of claim 1~7 any one of them containing birds nest extract, its feature
It is, comprises the following steps：
(1) each component raw material is weighed in proportion, is sieved；
(2) thickener is dissolved in deionized water, be sufficiently stirred, obtain water phase；
(3) by birds nest extract, Angelica Dahurica extract, Honegsukle flower P.E, camomile extract, phosphatide, cholesterol, liquid fatty
1 is pressed with emulsifying agent:30~45 mass ratio is dissolved in chloroform soln, is sufficiently stirred to obtain oil phase at 75~95 DEG C；
(4) oil phase is placed in container, in decompression rotary evaporation chloroform, phosphatide is formed film in wall, then add
Phosphate buffer solution, aquation is overnight, formation liposome turbid liquor, and ultrasound under ice bath, obtains liposome；
(5) the water phase for obtaining liposome addition step (2), is stirred continuously at 70~85 DEG C, stirs evenly, be cooled to room
Temperature, obtains the nti-freckle lipid gel containing birds nest extract.
9. the preparation method of the nti-freckle lipid gel according to claim 8 containing birds nest extract, it is characterised in that described
In step (1), birds nest extract, Angelica Dahurica extract, Honegsukle flower P.E and camomile extract are crossed into 200 mesh sieves.
10. according to nti-freckle lipid gel of claim 1~7 any one of them containing birds nest extract answering in cosmetics
With.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711280734.XA CN107951810A (en) | 2017-12-06 | 2017-12-06 | A kind of nti-freckle lipid gel, preparation method and applications containing birds nest extract |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112891270A (en) * | 2021-01-29 | 2021-06-04 | 洪怡 | Cosmetic composition and preparation method and application thereof |
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2017
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112891270A (en) * | 2021-01-29 | 2021-06-04 | 洪怡 | Cosmetic composition and preparation method and application thereof |
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