CN107951737A - Anti-wrinkle anti-allergy eye cream containing stem cell growth factors and preparation method and application thereof - Google Patents
Anti-wrinkle anti-allergy eye cream containing stem cell growth factors and preparation method and application thereof Download PDFInfo
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- CN107951737A CN107951737A CN201711279686.2A CN201711279686A CN107951737A CN 107951737 A CN107951737 A CN 107951737A CN 201711279686 A CN201711279686 A CN 201711279686A CN 107951737 A CN107951737 A CN 107951737A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/925—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of animal origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/86—Products or compounds obtained by genetic engineering
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Abstract
The invention belongs to the field of cosmetics, and particularly relates to anti-wrinkle and anti-allergy eye cream containing stem cell growth factors, and a preparation method and application thereof. The anti-wrinkle anti-allergy eye cream comprises the following components: the anti-wrinkle and anti-allergy eye cream can obviously remove eye wrinkles and canthus fish tail lines, relieve eye fatigue and avoid the generation of fat particles by reasonably compounding active components of the alkaline fibroblast growth factor, the dipeptide-2, the dipeptide-4, a liquorice extract, a calendula extract and the like; the liquorice extract and the calendula extract are added in a compounding manner, so that the pigmentation can be reduced, the skin inflammation can be alleviated, and the skin sensitivity can be reduced. The anti-wrinkle anti-allergy eye cream provided by the invention is milder and is suitable for people with sensitive skin.
Description
Technical field
The invention belongs to skin care field, and in particular to a kind of crease-resistant antiallergic eye cream containing stem cell factor and its
Preparation method and application.
Background technology
Eye part skin is different from normal skin, mainly：Skin is thinner, sweat gland is few, without sebaceous glands, cuticula is thin, eye
Portion's sub-surface porosity connective tissue enriches, containing the difference such as thinner of substantial amounts of capillary, capillary.The work and life of high rhythm
It is living so as to stay up late, work overtime as the life normality of many people, this is to causing eye fatigue, deepening eyeprint, acceleration eye muscle
Aging plays the role of adding fuel to the flames, especially for women, it is particularly important that the maintenance of eye skin.
Current market sales of eye cream is mostly good to wither uneven, some eye cream absorbing states are uncertain, some functional effects
Unobvious, some can even cause the adverse reactions such as fat granule, allergy.Such as：If the eye cream used is improper, can also give
Eye skin brings certain harmful effect.Such as most nutritional activities higher, contained containing lubricant component in existing eye cream
Component release is too fast and is not easy to be absorbed, these greases or nutritional ingredient are deposited on eye part skin, are easy to make for a long time in the past
Into the generation of fat granule, fat granule influences to despise once it is difficult to eliminate in the short time to produce caused by eye part skin；
But if using the more frivolous eye cream of quality, and can decline the moist degree of eye cream, good maintenance effect is not reached.It is right
In sensitive skin, easily there is the symptom such as red blood silk, oedema, telangiectasis after being subject to environmental stimuli, skin easily has convulsion
Itch, shouting pain, scorching hot, tight feeling etc. is felt, uses the meetings such as skin-protection product (including face cleaning, moisturizing, toner, color make-up, sunscreen products)
Trigger flush, itch or shouting pain, scorching hot, convulsion itch, furfur etc..In addition, crease-resistant type eye cream currently on the market, also there is nothing
Method takes into account moisturizing and crease-resistant double effects, makes its nursing efficacy bad.
For these reasons, a kind of new eye cream formula is developed, to overcome the problem of the prior art, just seems and particularly must
Will.
The content of the invention
For overcome the deficiencies in the prior art and shortcoming, primary and foremost purpose of the invention is to provide a kind of containing stem cell life
The crease-resistant antiallergic eye cream of the long factor.
Another object of the present invention is to provide the preparation side of the above-mentioned crease-resistant antiallergic eye cream containing stem cell factor
Method.
It is still another object of the present invention to provide the application of the above-mentioned crease-resistant antiallergic eye cream containing stem cell factor.
The purpose of the present invention is achieved through the following technical solutions：
A kind of crease-resistant antiallergic eye cream containing stem cell factor, includes component as follows in parts by mass：
The crease-resistant antiallergic eye cream containing stem cell factor, preferably comprises following component in parts by mass：
The human stem cell growth is preferably：With gene engineering method prepare recombined human stem cell growth because
Sub or naturally isolated application cell nutrient solution people source human stem cell growth；
The human stem cell growth is more preferably at least one of hSCGF- α and hSCGF- β；
Glycyrrhizic acid (C in the licorice42H62O16) it is not less than 2%；
The pot marigold extract Lutein content is not less than 20%；
The preparation method of the crease-resistant antiallergic eye cream containing stem cell factor, comprises the following steps：
(1) by macadimia nut oil, carbonic acid dicaprylate, dimethyl silicone polymer, glucoside, stearine, sheep
Hair fat is added in oil phase pot, and 60~80 DEG C of heating stirrings obtain A phases to being completely dissolved；
(2) glycerine, pungent glycol, xanthans and water are mixed, 60~80 DEG C of heating stirrings obtain B phases to being completely dissolved；
(3) 60~80 DEG C, under stirring, A is added in B phases；Then 10~20min of vacuum emulsifying, obtains cream
Body；
(4) when lotion made from step (3) is cooled to below 40 DEG C, by remaining ingredient (stem cell factor, alkali
Property fibroblast growth factor, dipeptides -2, dipeptides -4, licorice, pot marigold extract) be added in lotion, stir
Uniformly, the crease-resistant antiallergic eye cream containing stem cell factor is obtained；
The crease-resistant antiallergic eye cream containing stem cell factor can further filling, packaging；
The application of the crease-resistant antiallergic eye cream in skin care field containing stem cell factor；
The principle of the present invention：
The present invention is by by active component stem cell factor, basic fibroblast growth factor, dipeptides -2 and two
Peptides -4 etc. rationally compound, and different effective active composition is produced synergistic function, promote collagen, elastic fibers and
Hyaluronic acid hyperplasia, lifts the water content of skin, reduces microgroove, can substantially remove eye wrinkle-removing and canthus fishtail line, eye of releiving
Portion's fatigue, avoid fat granule from generating.In addition, licorice have anti-inflammatory, releive, detoxify, is antibacterial, promote immune, whitening,
Anti-acne, anti-aging and other effects, pot marigold extract have anti-inflammatory, antibacterial action, licorice, pot marigold extract
Compounding addition, can mitigate pigmentation, alleviate scytitis, reduce cutaneous sensibility and improve anti-wrinkle effect.
The present invention is had the following advantages relative to the prior art and effect：
(1) compatibility science of the present invention, rationally, there is provided the crease-resistant antiallergic eye cream containing stem cell factor can promote glue
Former albumen, elastic fibers and hyaluronic acid hyperplasia, lift the water content of skin, reduce microgroove, can substantially remove eye wrinkle-removing and
Canthus fishtail line, eye strain of releiving, avoid fat granule from generating.
(2) the crease-resistant antiallergic eye cream milder provided by the invention containing stem cell factor, is applicable to sensitive skin
Crowd.
Embodiment
With reference to embodiment, the present invention is described in further detail, but the implementation of the present invention is not limited to this.
Stem cell factor is hSCGF- α in embodiment, purchased from Peprotech companies；Glycyrrhizic acid in licorice
(C42H62O16) it is more than 2%, pot marigold extract Lutein content is more than 20%, purchased from the limited public affairs of the gloomy biotechnology in Xi'an source
Department；
Embodiment 1
A kind of crease-resistant antiallergic eye cream containing stem cell factor, includes component as follows in parts by mass：
The preparation method of the crease-resistant antiallergic eye cream containing stem cell factor, comprises the following steps：
(1) by macadimia nut oil, carbonic acid dicaprylate, dimethyl silicone polymer, glucoside, stearine, sheep
Hair fat is added in oil phase pot, and 70 DEG C of heating stirrings obtain A phases to being completely dissolved；
(2) glycerine, pungent glycol, xanthans and water are mixed, 70 DEG C of heating stirrings obtain B phases to being completely dissolved；
(3) 70 DEG C, under stirring, A is added in B phases；Then vacuum emulsifying 15min, obtains lotion；
(4) when lotion made from step (3) is cooled to 37 DEG C, by remaining ingredient (stem cell factor, alkalescence into
Fibroblast growth factor, dipeptides -2, dipeptides -4, licorice, pot marigold extract) it is added in lotion, stirring is equal
It is even, obtain the crease-resistant antiallergic eye cream containing stem cell factor；
(5) the crease-resistant antiallergic eye cream containing stem cell factor made from step (4) is further filling, packs, and obtains into
Crease-resistant antiallergic eye cream of the product containing stem cell factor.
Embodiment 2
A kind of crease-resistant antiallergic eye cream containing stem cell factor, includes component as follows in parts by mass：
The preparation method of the crease-resistant antiallergic eye cream containing stem cell factor, comprises the following steps：
(1) by macadimia nut oil, carbonic acid dicaprylate, dimethyl silicone polymer, glucoside, stearine, sheep
Hair fat is added in oil phase pot, and 70 DEG C of heating stirrings obtain A phases to being completely dissolved；
(2) glycerine, pungent glycol, xanthans and water are mixed, 70 DEG C of heating stirrings obtain B phases to being completely dissolved；
(3) 70 DEG C, under stirring, A is added in B phases；Then vacuum emulsifying 20min, obtains lotion；
(4) when lotion made from step (3) is cooled to 40 DEG C, by remaining ingredient (stem cell factor, alkalescence into
Fibroblast growth factor, dipeptides -2, dipeptides -4, licorice, pot marigold extract) it is added in lotion, stirring is equal
It is even, obtain the crease-resistant antiallergic eye cream containing stem cell factor；
(5) the crease-resistant antiallergic eye cream containing stem cell factor made from step (4) is further filling, packs, and obtains into
Crease-resistant antiallergic eye cream of the product containing stem cell factor.
Embodiment 3
A kind of crease-resistant antiallergic eye cream containing stem cell factor, includes component as follows in parts by mass：
The preparation method of the crease-resistant antiallergic eye cream containing stem cell factor, comprises the following steps：
(1) by macadimia nut oil, carbonic acid dicaprylate, dimethyl silicone polymer, glucoside, stearine, sheep
Hair fat is added in oil phase pot, and 80 DEG C of heating stirrings obtain A phases to being completely dissolved；
(2) glycerine, pungent glycol, xanthans and water are mixed, 80 DEG C of heating stirrings obtain B phases to being completely dissolved；
(3) 80 DEG C, under stirring, A is added in B phases；Then vacuum emulsifying 10min, obtains lotion；
(4) when lotion made from step (3) is cooled to 40 DEG C, by remaining ingredient (stem cell factor, alkalescence into
Fibroblast growth factor, dipeptides -2, dipeptides -4, licorice, pot marigold extract) it is added in lotion, stirring is equal
It is even, obtain the crease-resistant antiallergic eye cream containing stem cell factor；
(5) the crease-resistant antiallergic eye cream containing stem cell factor made from step (4) is further filling, packs, and obtains into
Crease-resistant antiallergic eye cream of the product containing stem cell factor.
Effect example
(1) periocualr skin flexibility test
The volunteer for meeting inclusion criteria through screening cleans both sides eye and surrounding skin, treats that its skin adapts to indoor ring
Behind border, eye cream is applied to the extremely absorption of circumference of eyes skin under staff's guidance, early, evening respectively once, is used continuously 30
My god.Periocualr skin is elastic before test product is tried out respectively, after 4 weeks, wherein, R2 (Ua/Uf) value indicates that skin is sprung back during no negative pressure
Amount Ua and the ratio between maximum tension amount Uf when having negative pressure, represents the entire change of skin elasticity, or is referred to as thick elasticity；R5(Ur/
Ue the ratio between the timely springback capacity Ur of skin and timely amount of tension Ue when having negative pressure, represents the fast of skin elasticity when) value is represented without negative pressure
Speed change, or it is referred to as net elasticity；R7 (Ur/Uf) value is maximum when indicating skin timely springback capacity Ur during no negative pressure and having negative pressure
The ratio between amount of tension Uf, represents the consolidation degree of skin.
1 is the results are shown in Table, eye cream made from embodiment 1~3 can obviously improve the elasticity of a surrounding skin, remove eye wrinkle
Line and canthus fishtail line.
Eye cream anti-wrinkle effect made from 1 embodiment 1~3 of table is evaluated
(2) skin tries out test for a long time
20 people (sensitive skin) are selected to be used as tester, average age was 35 one full year of life.Subject is early later than clean daily
The dosage of about soybean grain size is taken to smear crease-resistant antiallergic eye cream in eye circumference behind face, altogether using 90d, every 15d skin tests
Instrument tests a skin, without using other similar products in the test same period.
The oil and pigment content that the periocualr skin after eye cream 90d is used continuously all have declined, and moisture, collagen are fine
Peacekeeping elastic index is all improved, no red blood silk, the symptom such as oedema, telangiectasis.
Above-described embodiment is the preferable embodiment of the present invention, but embodiments of the present invention and from above-described embodiment
Limitation, other any Spirit Essences without departing from the present invention with made under principle change, modification, replacement, combine, letter
Change, should be equivalent substitute mode, be included within protection scope of the present invention.
Claims (9)
1. a kind of crease-resistant antiallergic eye cream containing stem cell factor, it is characterised in that include component as follows in parts by mass：
2. the crease-resistant antiallergic eye cream according to claim 1 containing stem cell factor, it is characterised in that comprising pressing as follows
The component of mass parts meter：
3. the crease-resistant antiallergic eye cream according to claim 1 or 2 containing stem cell factor, it is characterised in that：
The human stem cell growth is：The restructuring human stem cell growth or application prepared with gene engineering method is thin
The naturally isolated people source human stem cell growth of born of the same parents' nutrient solution.
4. the crease-resistant antiallergic eye cream according to claim 3 containing stem cell factor, it is characterised in that：
The human stem cell growth is at least one of hSCGF- α and hSCGF- β.
5. the crease-resistant antiallergic eye cream according to claim 1 or 2 containing stem cell factor, it is characterised in that：
Glycyrrhizic acid is not less than 2% in the licorice.
6. the crease-resistant antiallergic eye cream according to claim 1 or 2 containing stem cell factor, it is characterised in that：
The pot marigold extract Lutein content is not less than 20%.
7. the preparation method of crease-resistant antiallergic eye cream of claim 1~6 any one of them containing stem cell factor, its feature
It is to comprise the following steps：
(1) by macadimia nut oil, carbonic acid dicaprylate, dimethyl silicone polymer, glucoside, stearine, lanolin
Add in oil phase pot, 60~80 DEG C of heating stirrings obtain A phases to being completely dissolved；
(2) glycerine, pungent glycol, xanthans and water are mixed, 60~80 DEG C of heating stirrings obtain B phases to being completely dissolved；
(3) 60~80 DEG C, under stirring, A is added in B phases；Then 10~20min of vacuum emulsifying, obtains lotion；
(4) when lotion made from step (3) is cooled to below 40 DEG C, remaining ingredient is added in lotion, is stirred evenly, is obtained
To the crease-resistant antiallergic eye cream containing stem cell factor.
8. the preparation method of the crease-resistant antiallergic eye cream according to claim 7 containing stem cell factor, it is characterised in that：
The crease-resistant antiallergic eye cream containing stem cell factor can further filling, packaging.
9. crease-resistant antiallergic eye cream of claim 1~6 any one of them containing stem cell factor is in skin care field
Using.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711279686.2A CN107951737A (en) | 2017-12-06 | 2017-12-06 | Anti-wrinkle anti-allergy eye cream containing stem cell growth factors and preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201711279686.2A CN107951737A (en) | 2017-12-06 | 2017-12-06 | Anti-wrinkle anti-allergy eye cream containing stem cell growth factors and preparation method and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108578265A (en) * | 2018-07-04 | 2018-09-28 | 广州领衔生物科技有限公司 | Maintenance stoste and its preparation method and application |
| CN113425646A (en) * | 2021-07-27 | 2021-09-24 | 华侨大学 | Anti-wrinkle eye cream composition and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068391A (en) * | 2010-12-30 | 2011-05-25 | 广州赛莱拉化妆品科技有限公司 | Application of human steam cell growth factors in cosmetics |
-
2017
- 2017-12-06 CN CN201711279686.2A patent/CN107951737A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102068391A (en) * | 2010-12-30 | 2011-05-25 | 广州赛莱拉化妆品科技有限公司 | Application of human steam cell growth factors in cosmetics |
Non-Patent Citations (4)
| Title |
|---|
| EC ATTAR等: "Regulation of hematopoietic stem cell growth", 《LEUKEMIA》 * |
| 中华人民共和国卫生部: "《化妆品卫生规范》", 31 January 2007 * |
| 国家药品监督管理局: "化妆品监督管理常见问题解答（一）", 《国家药品监督管理局官网》 * |
| 王建新 等: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108578265A (en) * | 2018-07-04 | 2018-09-28 | 广州领衔生物科技有限公司 | Maintenance stoste and its preparation method and application |
| CN113425646A (en) * | 2021-07-27 | 2021-09-24 | 华侨大学 | Anti-wrinkle eye cream composition and preparation method thereof |
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