CN107941613A - Biological respinse and soft tissue mechanics multifunctional testing integrated instrument - Google Patents
Biological respinse and soft tissue mechanics multifunctional testing integrated instrument Download PDFInfo
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- CN107941613A CN107941613A CN201711127119.5A CN201711127119A CN107941613A CN 107941613 A CN107941613 A CN 107941613A CN 201711127119 A CN201711127119 A CN 201711127119A CN 107941613 A CN107941613 A CN 107941613A
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- placing groove
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N3/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N3/08—Investigating strength properties of solid materials by application of mechanical stress by applying steady tensile or compressive forces
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N3/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N3/24—Investigating strength properties of solid materials by application of mechanical stress by applying steady shearing forces
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Strength Of Materials By Application Of Mechanical Stress (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a kind of biological respinse and soft tissue mechanics multifunctional testing integrated instrument, it includes stretching device, pressurizing unit, shear and sample placing groove, and sample placing groove is used to place test sample, is additionally operable to as the biological reaction container for preparing sample；Stretching device includes at least two along at least two motors, at least two first pressure sensors that different directions move the stretching module of setting, driving stretching module moves；Pressurizing unit includes being arranged on above sample placing groove and adjusting mechanism, displacement sensor and the second pressure sensor moving up and down for extruding measuring head, being connected with extruding measuring head and driving extruding measuring head to move in the horizontal direction；Shear includes adjusting block, the 3rd pressure sensor, the objective table for placing test sample and can move in the horizontal direction that shearing piece can be driven to move up and down.A variety of test patterns are integrated by the way of space multistory layout and in same test platform, are realized multi-modal integrated testing by the present invention.
Description
Technical field
The present invention relates to a kind of biological respinse and soft tissue mechanics multifunctional testing integrated instrument, belongs to biomedical engineering neck
Domain.
Background technology
The mechanical property testing of soft tissue is the important directions of biomedical engineering field.In the prior art, soft group is carried out
The instrument for knitting mechanical property testing has the following disadvantages：1. the structure and physical characteristic of different biologic soft tissues are different, need
To be directed to its structure and physical features carry out test under different deformation mode, take a broad view of existing soft tissue tester, test mould
State is more single, is designed for a certain specific soft tissue, or can only carry out the test under a kind of deformation mode, it is difficult to complexity
Tissue carries out quantitative analysis；2. test needs to use different test platforms between different modalities, same sample cannot exist at the same time
Different directions is stretched, is sheared, extruding test；3. soft tissue is tested to be needed to use in different platform with bioreactor；
4. the behavior response under the specific border condition and stress state of tissue cannot be simulated, it is difficult to carry out different prestressing force bars
Test under part.
The content of the invention
It is an object of the invention to propose a kind of biological respinse and soft tissue mechanics multifunctional testing integrated instrument.
In order to achieve the above object, the present invention provides a kind of technical solution：Biological respinse is multi-functional with soft tissue mechanics
Testing integrated instrument, it includes stretching device, pressurizing unit, shear and sample placing groove,
Sample placing groove is used to place test sample, is additionally operable to as the biological reaction container for preparing sample, or as sample
This prestressing force and experiment boundary condition simulation device；
Stretching device includes at least two along different directions move the stretching module of setting, driving is drawn correspondingly respectively
Stretch at least two motors of module movement, for accordingly carrying out at least two of power measurement to stretching module in tension test
First pressure sensor, at least two stretching modules have in sample placing groove setting, each stretching module and test specimens
The connecting portion that product are separatably connected；
Pressurizing unit includes being arranged on above sample placing groove and extruding measuring head moving up and down and extruding measuring head
Be connected and drive extruding measuring head move in the horizontal direction adjusting mechanism, in squeeze test to extrude measuring head
Carry out the displacement sensor and second pressure sensor of range measurement and power measurement；
Shear include can adjust shear plate move up and down adapt to different test sample thickness adjusting block, for
The 3rd pressure sensor that is measured during shearing test to shearing force, simultaneously can be in the horizontal direction for placing test sample
Mobile objective table, objective table have at least four installment states, and at least four installment states include the first shape being horizontally mounted
State, the second state being rotated by 90 ° in the horizontal plane relative to first state, rotate relative to first state 180 ° in the horizontal plane
Three condition, the 4th state for rotating relative to first state 270 ° in the horizontal plane.
Further, connecting portion separatably clamps test sample.
Further, at least two pairs of stretching module, one pair of which is symmetrically set and moving direction is along left and right
Direction, another pair is symmetrically set and moving direction is along the longitudinal direction.
Further, sample placing groove have four respectively forwardly, rear, the extension of left and right direction extension, put sample
It is in cross to put groove.
Further, two pairs of stretching modules are respectively correspondingly arranged on the top of four extensions.
Further, adjusting mechanism includes supporting rack, the silk that can be arranged on movably forward and backward on supporting rack of fixed setting
Thick stick, the slide unit that can be movably connected on leading screw, extruding measuring head can be movably attached along the vertical direction to be slided
The lower section of component.
Further, leading screw by regulation handle come the shift position of adjusting screw.
Further, objective table drives its movement by a motor.
Further, objective table is positioned in sample placing groove in which can take out, when carrying out shearing test, at objective table
It is separated in installment state, and with sample placing groove；When carrying out tension test or squeeze test, objective table is positioned over sample and puts
Put in groove.
Further, at least four installment states of objective table are removably installed by fixture.
Due to the adoption of the above technical scheme, biological respinse of the present invention and soft tissue mechanics multifunctional testing integrated instrument, are compared
The prior art, has the following advantages：
1st, of the invention for carrying out in multi-modal test, stretching is difficult to unified, quasi-static and dynamic with shearing test structure
Test is difficult to the technological difficulties combined, using interchangeability structure, the drive of interaction arrangement different modalities in plane and solid space
Dynamic structure；By the way of space multistory layout, a variety of test patterns are integrated in same test platform, realize multi-modal one
Bodyization is tested；
2nd, the biaxial tension to test sample can be realized by technical scheme；
3rd, multi-modal test can be carried out at the same time, while carry out simulation survey to state of the soft tissue under various boundary
Examination：It is presetting with simulating by carrying out stress to the stress of sample in vivo, right close in the state of internal true environment
Soft tissue sample carries out comprehensive mechanical property testing, passes through the meter of sample stress distribution and drawing force in testing biaxial tension
Point counting is analysed, and conversed analysis is carried out to the stress distribution born in soft tissue in vivo environment with reference to numerical simulation.Tester is put down
Face driving structure, can be with respective drive plane test module, according to prestressed backwards calculation to soft tissue sample in vivo
State is reproduced.Meanwhile tester conveniently can apply perimeter strip by plane and vertical drive module to sample
Part, realize dynamic test in internal and external consistent of boundary condition, analysis of testing to the effect of multiple mode model test；
4th, using fixed sample placement platform, lossless and fast transfer is carried out to fixed sample；
5th, gather bioreactor and tissue characteristics to test, it is possible to achieve biomaterial reaction preparation with it is test integrated.
Described above is only the general introduction of technical solution of the present invention, in order to better understand the technological means of the present invention,
And can be practiced according to the content of specification, below with presently preferred embodiments of the present invention and coordinate attached drawing describe in detail as after.
Brief description of the drawings
Attached drawing 1 is the dimensional structure diagram of biological respinse of the present invention and soft tissue mechanics multifunctional testing integrated instrument；
Attached drawing 2 is the dimensional structure diagram of biological respinse of the present invention and soft tissue mechanics multifunctional testing integrated instrument, its
Visual angle is different from attached drawing 1；
Attached drawing 3 is biological respinse of the present invention and the main structure diagram of soft tissue mechanics multifunctional testing integrated instrument.
Figure label is：
1st, testboard；2nd, sample placing groove；3rd, motor；4th, stretching module；5th, sliding block；6th, guided way；7th, first pressure passes
Sensor；8th, second pressure sensor；9th, displacement sensor；10th, measuring head is extruded；11st, supporting rack；12nd, leading screw；13rd, sliding part
Part；14th, regulation handle；15th, adjusting block；16th, shear plate；17th, guide part；18th, objective table；19th, the 3rd pressure sensor；20、
Fixture.
Embodiment
With reference to the accompanying drawings and examples, the embodiment of the present invention is described in further detail.Implement below
Example is used to illustrate the present invention, but is not limited to the scope of the present invention.
1 to attached drawing 3 referring to the drawings, the biological respinse in the present embodiment and soft tissue mechanics multifunctional testing integrated instrument, it
Including testboard 1, the stretching device being arranged on testboard 1, pressurizing unit, shear and sample placing groove 2.
Sample placing groove 2 is fixed on testboard 1, for placing test sample, is additionally operable to as preparing sample
Biological reaction container.In the present embodiment, sample placing groove 2 have four respectively forwardly, rear, left and right four horizontal directions extension
Extension so that sample placing groove 2 is in cross shape, to coordinate simple tension or two-way drawing of the stretching device to test sample
Stretch, while play the positioning action to objective table 18, avoid objective table 18 from being moved in sample placing groove 2 and influence test knot
Fruit.Objective table 18 will hereinafter be described.
Stretching device is used to carry out test sample one-way or bi-directional extension test.It includes at least two along not Tongfang
To the mobile stretching module 4 set, drive at least two motors 3 of the movement of stretching module 4 correspondingly respectively, for drawing
At least two first pressure sensors 7 of power measurement are accordingly carried out when stretching experiment to stretching module 4.Stretched in tension test
The range measurement of module 4 is by being measured and being calculated to its corresponding output of motor 3.
At least two stretching modules 4 are set around sample placing groove 2.In a kind of highly preferred embodiment, stretching
Module 4 at least four, i.e., two pairs, one pair of which is moved and is symmetrical arranged in left-right direction respectively, and another pair is respectively along preceding
Rear direction is mobile and is symmetrical arranged.At least two above-mentioned first pressure sensors 7 have two, above-mentioned a pair of of stretching module 4
By a first pressure sensor 7 come measuring force, another pair stretching module 4 by another first pressure sensor 7 come
Measuring force.
In the present embodiment, stretching module 4 is connected on a sliding block 5, and motor 3 drives sliding block 5 to move by leading screw and nut mechanism
It is dynamic.Sliding block 5 is connected with 6 phase shift of a guided way, and is moved along the length direction of the guided way 6.Guided way 6 and motor 3 are equal
It is fixedly connected on testboard 1.Four extensions of the length direction of each guided way 6 respectively along cross sample placing groove 2
Extending direction set.
There is the connecting portion being separatably connected with test sample on each stretching module 4.Connection in the present embodiment
Portion uses clamping structure, separatably clamps test sample.And lever principle is utilized, by the equivalent biography of the drawing force of test sample
Pass first pressure sensor 7.
Based on said structure, the stretching device in the present embodiment can realize the biaxial tension to test sample.Therefore, originally
Sample placing groove 2 in embodiment is alternatively arranged as sample prestressing force and experiment boundary condition simulation device.By to sample in vivo
Stress progress stress is presetting with simulating, and comprehensive power is being carried out to soft tissue sample close in the state of internal true environment
Characteristic test is learned, is analyzed by the calculating of sample stress distribution and drawing force in testing biaxial tension, with reference to numerical simulation pair
The stress distribution that soft tissue is born in environment in vivo carries out conversed analysis.The plane driving structure of the multifunctional integrated instrument of this test
According to prestressed backwards calculation, the state of soft tissue sample in vivo can be carried out again with respective drive plane test module
It is existing.Meanwhile the multifunctional integrated instrument of this test conveniently can apply border by plane and vertical drive module to sample
Condition, realize dynamic test in internal and external consistent of boundary condition, test to the effect of multiple mode model test point
Analysis.
Pressurizing unit includes being arranged on the top of sample placing groove 2 and extruding measuring head 10 moving up and down and extruding are surveyed
Examination first 10 be connected and drive extruding measuring head 10 move in the horizontal direction adjusting mechanism, in squeeze test to squeeze
Measuring head 10 is pressed to carry out the displacement sensor 9 and second pressure sensor 8 of range measurement and power measurement.
In the present embodiment, adjusting mechanism includes the supporting rack 11 of fixed setting, can be arranged on supporting rack 11 movably forward and backward
On leading screw 12, the slide unit 13 that can movably be connected on leading screw 12, extruding measuring head 10 can move along the vertical direction
The lower section of slide unit 13 is connected to dynamicly.Leading screw 12 is by regulation handle 14 come the shift position of adjusting screw 12.
Shear moves up and down the adjusting block 15 for adapting to different test sample thickness, use including that can adjust shear plate 16
The 3rd pressure sensor 19 that is measured when in shearing test to shearing force, simultaneously can be in level for placing test sample
The objective table 18 just moved up.16 and the 3rd pressure sensor 19 of shear plate is connected on adjusting block 15.
In the present embodiment, objective table 18 is moved through an above-mentioned motor 3 to drive.Specifically, objective table 18 is set
Put on an above-mentioned sliding block 5, driven by connecting the motor 3 of the sliding block 5.In a kind of highly preferred embodiment
In, objective table 18 is separatably connected with the sliding block 5.
Objective table 18 has at least four installment states, which includes the first shape being horizontally mounted
State, the second state being rotated by 90 ° in the horizontal plane relative to the first state, rotate relative to the first state in the horizontal plane
180 ° of the third state, the 4th state for rotating relative to the first state 270 ° in the horizontal plane, relatively described first state
The second state being rotated by 90 ° in the horizontal plane.Objective table 18 can be rotated arbitrarily around itself vertical central axis in the horizontal plane
90 ° are installed, with realize to sample different directions shearing.Specifically, at least four installment states of objective table 18 are equal
It is removably installed by fixture 20, objective table 18 is clamped on above-mentioned sliding block 5 by fixture 20, and can after disengaging
Any be rotated by 90 ° is connected with sliding block 5 again, exists so as to be realized by a driving motor 3 to the test sample on objective table 18
Position in horizontal direction (all around) is adjusted.Shear plate 16 itself and objective table is adjusted by moving up and down for adjusting block 15
Vertical distance between 18, so as to adapt to the thickness of test sample.
In a kind of highly preferred embodiment, objective table 18 is positioned in sample placing groove 2 in which can take out, when into
During row shearing test, objective table 18 is connected on sliding block 5 and is separated with sample placing groove 2, when progress tension test or extruding
During experiment, objective table 18 departs from sliding block 5 and is positioned in sample placing groove 2.Objective table 18 uses criss-cross shape design, when its matching
When being put into sample placing groove 2 with closing, sample placing groove 2 can limit the movement in 18 horizontal direction of objective table, avoid loading
Platform 18 moves in sample placing groove 2 and influences test result.
Shear further includes the guide part 17 of fixed setting, and adjusting block 15 can be up or down by leading screw and nut mechanism
It is connected on the guide part 17.In the present embodiment, guide part 17 is fixedly connected on testboard 1, and is located at driving objective table 18
The side of mobile motor 3.
Due to the adoption of the above technical scheme, biological respinse of the present invention and soft tissue mechanics multifunctional testing integrated instrument, have
Advantages below：1st, of the invention for carrying out in multi-modal test, stretching is difficult to unified, quasi-static and dynamic with shearing test structure
Test is difficult to the technological difficulties combined, using interchangeability structure, the drive of interaction arrangement different modalities in plane and solid space
Dynamic structure；By the way of space multistory layout, a variety of test patterns are integrated in same test platform, realize multi-modal one
Bodyization is tested；2nd, the biaxial tension to test sample can be realized by technical scheme；3rd, multi-modal test can be with
It is carried out at the same time, while simulation test is carried out to state of the soft tissue under various boundary；4th, placed using fixed sample flat
Platform, lossless and fast transfer is carried out to fixed sample；5th, gather bioreactor and tissue characteristics are tested, it is possible to achieve biological material
Material reaction prepare with it is test integrated.
The above is only the preferred embodiment of the present invention, is not intended to limit the invention, it is noted that for this skill
For the those of ordinary skill in art field, without departing from the technical principles of the invention, can also make it is some improvement and
Modification, these improvements and modifications also should be regarded as protection scope of the present invention.
Claims (10)
1. a kind of biological respinse and soft tissue mechanics multifunctional testing integrated instrument, it is characterised in that：It includes stretching device, extruding
Device, shear and sample placing groove,
The sample placing groove is used to place test sample, is additionally operable to as the biological reaction container for preparing sample；
The stretching device moves the stretching module of setting along different directions, drives correspondingly respectively including at least two
At least two motors of stretching module movement, for accordingly carrying out power measurement to the stretching module in tension test
At least two first pressure sensors, at least two stretching modules set around the sample placing groove, each stretching
There is the connecting portion being separatably connected with the test sample in module；
The pressurizing unit includes being arranged on above the sample placing groove and extruding measuring head moving up and down, with it is described
Extruding measuring head be connected and drive it is described extruding measuring head move in the horizontal direction adjusting mechanism, in squeeze test
When to it is described extruding measuring head carry out range measurement and power measurement displacement sensor and second pressure sensor；
The shear includes shear plate can be driven to move up and down to adapt to the adjusting block of different test sample thickness, use
The 3rd pressure sensor that is measured when in shearing test to shearing force, simultaneously can be in water for placing the test sample
Square objective table moved up, the objective table have at least four installment states, at least four installment state bags
Include the first state being horizontally mounted, the second state that relatively described first state is rotated by 90 ° in the horizontal plane, relatively described first
State rotates 180 ° of the third state, rotates 270 ° of the 4th shape in the horizontal plane relative to the first state in the horizontal plane
State.
2. biological respinse according to claim 1 and soft tissue mechanics multifunctional testing integrated instrument, it is characterised in that：It is described
Connecting portion separatably clamp the test sample.
3. biological respinse according to claim 1 and soft tissue mechanics multifunctional testing integrated instrument, it is characterised in that：It is described
At least two pairs of stretching module, one pair of which is symmetrically set and moving direction is another pair phase in left-right direction
Mutually it is symmetrical arranged and moving direction is along the longitudinal direction.
4. the biologic soft tissue multifunctional tester according to claim 1 or 3, it is characterised in that：The sample is placed
Groove have four respectively forwardly, rear, the extension of left and right direction extension, it is in cross to make the sample placing groove.
5. biological respinse according to claim 4 and soft tissue mechanics multifunctional testing integrated instrument, it is characterised in that：Two pairs
The stretching module is respectively correspondingly arranged on the top of four extensions.
6. biological respinse according to claim 1 and soft tissue mechanics multifunctional testing integrated instrument, it is characterised in that：It is described
Adjusting mechanism include fixed setting supporting rack, can be arranged on movably forward and backward on support frame as described above leading screw, can left and right move
The slide unit being connected to dynamicly on the leading screw, the extruding measuring head can be movably attached in the cunning along the vertical direction
The lower section of dynamic component.
7. biological respinse according to claim 6 and soft tissue mechanics multifunctional testing integrated instrument, it is characterised in that：It is described
Leading screw by regulation handle come the shift position of adjusting screw.
8. biological respinse according to claim 1 and soft tissue mechanics multifunctional testing integrated instrument, it is characterised in that：It is described
Objective table its movement is driven by a motor.
9. biological respinse and soft tissue mechanics multifunctional testing integrated instrument according to claim 1 or 8, it is characterised in that：
The objective table is positioned in the sample placing groove in which can take out, when carrying out shearing test, at the objective table
It is separated in the installment state, and with sample placing groove；When carrying out tension test or squeeze test, the objective table
It is positioned in sample placing groove.
10. biological respinse according to claim 8 and soft tissue mechanics multifunctional testing integrated instrument, it is characterised in that：Institute
At least four installment states for stating objective table are removably installed by fixture.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711127119.5A CN107941613B (en) | 2017-11-15 | 2017-11-15 | Multifunctional testing integrated instrument for biological reaction and soft tissue mechanics |
| PCT/CN2017/112222 WO2019095409A1 (en) | 2017-11-15 | 2017-11-22 | Integrated multifunctional test instrument for biological reaction and soft tissue mechanics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711127119.5A CN107941613B (en) | 2017-11-15 | 2017-11-15 | Multifunctional testing integrated instrument for biological reaction and soft tissue mechanics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107941613A true CN107941613A (en) | 2018-04-20 |
| CN107941613B CN107941613B (en) | 2020-10-09 |
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| CN201711127119.5A Expired - Fee Related CN107941613B (en) | 2017-11-15 | 2017-11-15 | Multifunctional testing integrated instrument for biological reaction and soft tissue mechanics |
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| WO (1) | WO2019095409A1 (en) |
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| CN111208007B (en) * | 2020-01-20 | 2022-06-03 | 通标标准技术服务有限公司 | Method for detecting mechanical property of textile material |
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| NL2034960A (en) | 2022-10-14 | 2023-07-07 | Univ Fudan | In vivo multidimensional stress-strain testing device for plantar soft tissues |
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| CN107941613B (en) | 2020-10-09 |
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