CN205483873U - Biological tissue elasticity measuring apparatu - Google Patents
Biological tissue elasticity measuring apparatu Download PDFInfo
- Publication number
- CN205483873U CN205483873U CN201620071471.6U CN201620071471U CN205483873U CN 205483873 U CN205483873 U CN 205483873U CN 201620071471 U CN201620071471 U CN 201620071471U CN 205483873 U CN205483873 U CN 205483873U
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- pressure head
- biological tissue
- measuring instrument
- overarm arm
- displacement
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Abstract
The utility model provides a biological tissue elasticity measuring apparatu, include: the platform is put to the sample for place and organize the sample, the pressure head presses under the effect of drive power organize the sample, with organize the specimen surface to produce certain indentation degree of depth, effort loading portion provides the pressure head presses the drive power of action, the displacement measurement device is used for measuring the displacement of pressure head, and the industrial computer, be used for control effort loading portion provides drive power and gathers the displacement signal of displacement measurement device. The utility model discloses can realize the elasticity of soft tissue block measures.
Description
Technical field
This utility model relates to the elasticity measurement technology of soft tissue block, raw particularly to a kind of indentation method detection
The measurement apparatus that fabric texture is elastic.
Background technology
The elasticity of biologic soft tissue is its pathological changes of identification whether important evidence, if the elastic of certain tissue becomes
Change, imply that this tissue starts certain pathological changes or damage, as cancer is usually expressed as tissue lump, capsule
The swollen structure being rendered as softness, and the disease of similar liver cirrhosis, fibrosis liver etc also can make the elastic system of liver
There is significantly change in number.Therefore, carry out the elastic measurement of biologic soft tissue and research, contribute to assisting disease
The Accurate Diagnosis of state of an illness condition and establish therapeutic scheme and the assessment to therapeutic scheme effect targetedly.
Although utilizing the elasticity of biological tissue and developing the various elastography of formation, such as resonance elastic
Imaging, ultra sonic imaging, acoustic radiation force impact imaging etc., it has also become the important means of clinical diagnosis, but,
Owing to elastography is only qualitative investigation to biological tissue elasticity, if can the most biological group further
The elasticity knitted, sets up the elastic data storehouse of pathological changes and normal structure, for the effectiveness and accurately of clinic diagnosis
Property, it will it is to strengthen greatly.
In recent years, the Nanoindentation grown up based on scanning probe microscopy successfully achieves carefully
The equivalent Young's modulus detection of born of the same parents and soft tissue microcell, the most further confirms that indentation method has quantitatively and behaviour
Make easy feature.But the purpose of the mechanical characteristic detection on biological tissue cell level is generally used for pathology
Research, it is impossible to the treatment for pathological changes block provides foundation.Such as the treatment of cardiovascular diseases, if blood vessel speckle can be obtained
Block mechanical characteristic, then the establishment to its therapeutic scheme and means is significant.
Utility model content
Technical problem to be solved in the utility model is to provide a kind of biological tissue elasticity measuring instrument, it is possible to real
The elasticity measurement of existing soft tissue block.
For solving the problems referred to above, the utility model proposes a kind of biological tissue elasticity measuring instrument, including:
Platform put by sample, is used for placing tissue sample；
Pressure head, presses described tissue sample under the effect of driving force, to produce on described tissue sample surface
Certain depth of cup；
Active force loading unit, it is provided that the driving force of described pressure head tactile depressing action；
Displacement measuring device, for measuring the displacement of described pressure head；And
Industrial computer, being used for controlling described active force loading unit provides driving force and gathers institute's displacement measurement device
Displacement signal.
According to an embodiment of the present utility model, described active force loading unit includes: overarm arm, solid on it
Surely described pressure head is connected；And driving means, it is used for driving described overarm arm to move downward to drive described pressure head
Press described tissue sample.
According to an embodiment of the present utility model, described overarm arm is micro-force sensitive device.
According to an embodiment of the present utility model, the coefficient of elasticity of described overarm arm is 10-3～102N/m it
Between.
According to an embodiment of the present utility model, described overarm arm is triangle frame-type overarm arm, described driving
Device connects the base of described triangle frame-type overarm arm, and described pressure head is fixedly connected on the overarm of described triangle frame-type
On the axis of arm.
According to an embodiment of the present utility model, described pressure head is fixedly connected on the end of described overarm arm.
According to an embodiment of the present utility model, also include that Three dimensions control platform, described active force loading unit set
Put on described Three dimensions control platform and can three-dimensional move, to adjust the phase para-position of described pressure head and tissue sample
Put.
According to an embodiment of the present utility model, described pressure head is spherical indenter.
According to an embodiment of the present utility model, institute's displacement measurement device is laser displacement sensor.
According to an embodiment of the present utility model, described laser displacement sensor is arranged on described pressure head
At side, and the Laser Measuring pilot described pressure head of alignment.
After using technique scheme, this utility model has the advantages that compared to existing technology and passes through
Active force loading unit band dynamic head completes the active force to tissue sample and loads and unloading, produces in tissue sample
Raw certain depth of cup, utilizes displacement measuring device to measure the displacement of pressure head, thus can obtain pressure head in group
Knit the depth of cup that specimen surface is formed, then according to the force curve between pressure head active force and depth of cup and phase
The theoretical model answered, can quantitative determine the equivalent Young's modulus of tissue sample contact area, it is possible to realize soft
The elasticity measurement of tissue block.
Accompanying drawing explanation
Fig. 1 is the perspective view of the biological tissue elasticity measuring instrument of this utility model one embodiment；
Fig. 2 is the side structure schematic diagram of the biological tissue elasticity measuring instrument of this utility model one embodiment；
Fig. 3 is the structural representation of the overarm arm of this utility model one embodiment.
Detailed description of the invention
Understandable for enabling above-mentioned purpose of the present utility model, feature and advantage to become apparent from, below in conjunction with attached
Detailed description of the invention of the present utility model is described in detail by figure.
Elaborate a lot of detail in the following description so that fully understanding this utility model.But this
Utility model can be implemented to be much different from alternate manner described here, and those skilled in the art are permissible
Doing similar popularization in the case of this utility model intension, therefore this utility model is not by described below
The restriction being embodied as.
Referring to Fig. 1 and Fig. 2, the biological tissue elasticity measuring instrument of the present embodiment, put platform 1, pressure including sample
2, active force loading unit, displacement measuring device 4 and industrial computer 5.Optionally, in FIG, biological
Tissue elasticity measuring instrument also includes that testing stand 7, the remaining part of biological tissue elasticity measuring instrument are all placed or solid
It is scheduled on testing stand 7, puts platform 1, pressure head 2, active force loading unit, displacement measuring device 4 including sample
With industrial computer 5 etc..
Sample is put for placing tissue sample on platform 1, and platform 1 put by sample can be such as one piece of backing plate.Certainly
Have testing stand 7 as supporting construction in the case of, it is also possible to the appropriate section of testing stand 7 is replaced examination
Platform 1 put by sample, is used for placing tissue sample 100, such that it is able to omit sample to put platform 1.Tissue sample 100
For the biologic soft tissue block that can deform upon under pressure.
Pressure head 2 is arranged on the top of tissue sample 100, and pressure head 2 presses tissue examination under the effect of driving force
Sample 100, pressure head 2 contact tissue sample 100 also produces corresponding directed force F to tissue sample 100, with
The degree of depth 2 times pressure tissue sample 100 of pressure head increases, and can produce certain depth of cup on tissue sample surface
δ.It is also preferred that the left pressure head 2 is spherical indenter, or the surface of pressure head 2 contact tissue sample 100 is spherical in shape
Curved surface.
Active force loading unit is used for providing the driving force of pressure head 2 tactile depressing action, and pressure head 2 is fixed on active force and adds
On the position that the one of load portion can move downward, this part moves downward band dynamic head 2 and moves downward and press tissue
Sample 100 surface.
Concrete, with continued reference to Fig. 1 and Fig. 2, active force loading unit can include hang oneself from a beam arm 31 and driving
Device 32, driving means 32 can be such as servomotor, and driving means 32 can in one embodiment
With the only one driving interface connecting motor.Fixing connection pressure head 2 on overarm arm 31, it is also preferred that the left pressure head 2
Being fixedly connected on the end away from driving means 32 (free end) of overarm arm 31, overarm arm 31 relatively should
The position of end connects the motive position of driving means 32.Driving means 32 drives overarm arm 31 to transport downwards
Move and press tissue sample 100 with band dynamic head 2.By the compressing of pressure head 2, tissue sample 100 surface meeting
Producing certain Dish deformation, the accurate step number by means of servomotor rotates, and can efficiently control depression
The degree of deformation.
It is also preferred that the left overarm arm 31 can be micro-force sensitive device, both can be as the force providing small power
Unit, can carry out high accuracy force measurement as Micro-force sensor again.
The coefficient of elasticity of overarm arm 31 is 10-3～102Between N/m optional, press tissue sample at pressure head 2
During 100, overarm arm 31 can occur certain elastic deformation.General action power is 10-5～10-2N,
Coefficient of elasticity is 10-3～102Cantilever beam between N/m 31 just can be produced by the least power and can detect that
Displacement, it is possible to reach the displacement high-resolution under micro-power.
Referring to Fig. 3, overarm arm 31 is preferably triangle frame-type overarm arm, the base 211 of triangle frame-type overarm arm
On there is fixed part 212, driving means 32 connect triangle frame-type overarm arm this fixed part 212 of base, pressure
On 2 axis being fixedly connected on triangle frame-type overarm arm, if deviation may cause triangle frame-type to be hung oneself from a beam arm
Bending.
Displacement measuring device 4 is for measuring the displacement of pressure head.Displacement measuring device 4 can be such as laser position
Displacement sensor, in order to accurately obtain depth of cup, selects high precision laser displacement sensor, and laser displacement passes
Sensor is arranged on above pressure head, and at Laser Measuring pilot alignment pressure head.
Referring to Fig. 2, when pressure head 2 contacts with tissue sample 100 surface and continues to load to tissue sample 100
During directed force F, cantilever beam 31 bends, and the Laser Measuring pilot on pressure head 2 can deviate original position,
I.e. pressure head 2 position is by z0Move to z1, therefore, ram position can be measured by laser displacement sensor
Change obtains depth of cup δ that pressure head produces on tissue sample 100 surface.
Industrial computer 5 provides driving force for control action power loading unit and gathers the displacement of displacement measuring device 4
Signal.Industrial computer 5 can have the displacement signal for gathering displacement measuring device 4 and overarm arm 31
Force signal data acquisition card and be used for control driving means 32 drive overarm arm 31 motion motor control
Card.Industrial computer 5 connect collection signal after, can according to pressure head radius R, directed force F, depth of cup δ with
Relation between tissue sample equivalent Young's modulus E* and determine equivalent Young's modulus E*, in FIG, industry control
Also there is on machine 5 display, can be used to show signal, the data of process or the figure etc. of process.
When choosing suitable ball-type pressure head diameter and tissue sample 100 size, it is believed that be spherical indenter 2
Contact with semo-infinite sample interface under responsive to axial force.Assuming that do not produce when rigid pressure head and sample contacts
Deformation, under small impression, pressure head radius R, directed force F, depth of cup δ and sample equivalence Young mould
Between amount E*, exist such as the relation of following formula (1):
Relation according to formula (1) and pressure head radius, active force, these known quantities of depth of cup, can be true
Determine the elastic modelling quantity of tissue sample 100.
In one embodiment, with continued reference to Fig. 1 and Fig. 2, biological tissue elasticity measuring instrument also includes three-dimensional
Control station 6, active force loading unit is arranged on Three dimensions control platform 6 and can be three-dimensional mobile, to adjust pressure head
2 with the relative position of tissue sample 100.Concrete, Three dimensions control platform 6 includes X-axis slide unit 61, Y
Axle slide unit 62 and Z axis slide unit 63, active force loading unit is arranged on Z axis slide unit 63, can relatively try
Test platform 7 surface three dimension to move.In one embodiment, displacement measuring device 4 is equally arranged on Z
On axle slide unit 63, displacement measuring device 4 together can be fixed on a support with overarm arm 31, is arranged on
Can move up and down on Z axis slide unit 63.
Although this utility model is open as above with preferred embodiment, but it is not for limiting claim,
Any those skilled in the art, without departing from spirit and scope of the present utility model, can make possible
Variation and amendment, protection domain the most of the present utility model should be defined with this utility model claim
Scope is as the criterion.
Claims (10)
1. a biological tissue elasticity measuring instrument, it is characterised in that including:
Platform put by sample, is used for placing tissue sample；
Pressure head, presses described tissue sample under the effect of driving force, to produce on described tissue sample surface
Certain depth of cup；
Active force loading unit, it is provided that the driving force of described pressure head tactile depressing action；
Displacement measuring device, for measuring the displacement of described pressure head；And
Industrial computer, being used for controlling described active force loading unit provides driving force and gathers institute's displacement measurement device
Displacement signal.
2. biological tissue elasticity measuring instrument as claimed in claim 1, it is characterised in that described active force adds
Load portion includes: overarm arm, the described pressure head of fixing connection on it；And driving means, it is used for driving described overarm
Arm moves downward to drive described pressure head to press described tissue sample.
3. biological tissue elasticity measuring instrument as claimed in claim 2, it is characterised in that described overarm arm is
Micro-force sensitive device.
4. biological tissue elasticity measuring instrument as claimed in claim 3, it is characterised in that described overarm arm
Coefficient of elasticity is 10-3～102Between N/m.
5. biological tissue elasticity measuring instrument as claimed in claim 2, it is characterised in that described overarm arm is
Triangle frame-type overarm arm, described driving means connects the base of described triangle frame-type overarm arm, and described pressure head is solid
Surely it is connected on the axis of described triangle frame-type overarm arm.
6. biological tissue elasticity measuring instrument as claimed in claim 2, it is characterised in that described pressure head is fixed
It is connected to the end of described overarm arm.
7. biological tissue elasticity measuring instrument as claimed in claim 1, it is characterised in that also include three-dimensional control
Platform processed, described active force loading unit is arranged on described Three dimensions control platform and can be three-dimensional mobile, to adjust
State the relative position of pressure head and tissue sample.
8. biological tissue elasticity measuring instrument as claimed in claim 1, it is characterised in that described pressure head is ball
Shape pressure head.
9. biological tissue elasticity measuring instrument as claimed in claim 1, it is characterised in that institute's displacement measurement
Device is laser displacement sensor.
10. biological tissue elasticity measuring instrument as claimed in claim 9, it is characterised in that described laser position
Displacement sensor is arranged on above described pressure head, and Laser Measuring pilot is directed at described pressure head.
Priority Applications (1)
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| CN201620071471.6U CN205483873U (en) | 2016-01-25 | 2016-01-25 | Biological tissue elasticity measuring apparatu |
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|---|---|---|---|
| CN201620071471.6U CN205483873U (en) | 2016-01-25 | 2016-01-25 | Biological tissue elasticity measuring apparatu |
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Cited By (11)
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| CN106370519A (en) * | 2016-10-13 | 2017-02-01 | 苏州大学张家港工业技术研究院 | Tester for micromechanical properties of biological soft tissue |
| CN106980096A (en) * | 2017-04-12 | 2017-07-25 | 苏州大学 | A kind of soft tissue simulator and analog detection method tested for magnetic resonance |
| CN108261182A (en) * | 2018-02-11 | 2018-07-10 | 天津大学 | Human facial skin's Mechanics Performance Testing device |
| CN108414378A (en) * | 2017-12-29 | 2018-08-17 | 南方科技大学 | The detecting system and method for the mechanical property of biological tissue |
| CN108645733A (en) * | 2018-05-14 | 2018-10-12 | 南京邮电大学 | A kind of touch sensor for measuring biological tissue elasticity modulus |
| CN108844819A (en) * | 2018-05-03 | 2018-11-20 | 中国石油大学(华东) | A kind of soft material surface breakdown strength test device and its test method |
| CN109520837A (en) * | 2018-12-19 | 2019-03-26 | 南京医科大学附属口腔医院 | Nano-hardness tester loading bench special bio soft tissue moisturizing device |
| WO2019098293A1 (en) * | 2017-11-15 | 2019-05-23 | 国立研究開発法人産業技術総合研究所 | Method for testing dynamic characteristics |
| WO2019095409A1 (en) * | 2017-11-15 | 2019-05-23 | 江苏铂影数据科技有限公司 | Integrated multifunctional test instrument for biological reaction and soft tissue mechanics |
| CN111693378A (en) * | 2020-07-31 | 2020-09-22 | 西京学院 | Device for measuring Young modulus of metal wire |
| NL2034960A (en) | 2022-10-14 | 2023-07-07 | Univ Fudan | In vivo multidimensional stress-strain testing device for plantar soft tissues |
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| WO2018068338A1 (en) * | 2016-10-13 | 2018-04-19 | 苏州大学张家港工业技术研究院 | Tester for micromechanical properties of biological soft tissue |
| CN106370519B (en) * | 2016-10-13 | 2018-06-12 | 苏州大学 | Biologic soft tissue Micromechanics characteristic tester |
| CN106370519A (en) * | 2016-10-13 | 2017-02-01 | 苏州大学张家港工业技术研究院 | Tester for micromechanical properties of biological soft tissue |
| CN106980096A (en) * | 2017-04-12 | 2017-07-25 | 苏州大学 | A kind of soft tissue simulator and analog detection method tested for magnetic resonance |
| CN106980096B (en) * | 2017-04-12 | 2023-11-24 | 苏州大学 | Soft tissue simulator for magnetic resonance test and simulation test method |
| WO2019095409A1 (en) * | 2017-11-15 | 2019-05-23 | 江苏铂影数据科技有限公司 | Integrated multifunctional test instrument for biological reaction and soft tissue mechanics |
| US11506583B2 (en) | 2017-11-15 | 2022-11-22 | National Institute Of Advanced Industrial Science And Technology | Test method for characterizing mechanical properties |
| JPWO2019098293A1 (en) * | 2017-11-15 | 2020-11-19 | 国立研究開発法人産業技術総合研究所 | Mechanical property test method |
| WO2019098293A1 (en) * | 2017-11-15 | 2019-05-23 | 国立研究開発法人産業技術総合研究所 | Method for testing dynamic characteristics |
| CN108414378A (en) * | 2017-12-29 | 2018-08-17 | 南方科技大学 | The detecting system and method for the mechanical property of biological tissue |
| CN108261182A (en) * | 2018-02-11 | 2018-07-10 | 天津大学 | Human facial skin's Mechanics Performance Testing device |
| CN108844819A (en) * | 2018-05-03 | 2018-11-20 | 中国石油大学(华东) | A kind of soft material surface breakdown strength test device and its test method |
| CN108645733B (en) * | 2018-05-14 | 2021-09-14 | 南京邮电大学 | Touch sensor for measuring elastic modulus of biological tissue |
| CN108645733A (en) * | 2018-05-14 | 2018-10-12 | 南京邮电大学 | A kind of touch sensor for measuring biological tissue elasticity modulus |
| CN109520837A (en) * | 2018-12-19 | 2019-03-26 | 南京医科大学附属口腔医院 | Nano-hardness tester loading bench special bio soft tissue moisturizing device |
| CN111693378A (en) * | 2020-07-31 | 2020-09-22 | 西京学院 | Device for measuring Young modulus of metal wire |
| NL2034960A (en) | 2022-10-14 | 2023-07-07 | Univ Fudan | In vivo multidimensional stress-strain testing device for plantar soft tissues |
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