CN107929839A - A kind of portable membrane oxygenator and preparation method and its oxygen close method - Google Patents
A kind of portable membrane oxygenator and preparation method and its oxygen close method Download PDFInfo
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- CN107929839A CN107929839A CN201810040696.9A CN201810040696A CN107929839A CN 107929839 A CN107929839 A CN 107929839A CN 201810040696 A CN201810040696 A CN 201810040696A CN 107929839 A CN107929839 A CN 107929839A
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- pellicle
- oxygen
- shell
- blood
- group
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- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title claims abstract description 176
- 239000001301 oxygen Substances 0.000 title claims abstract description 176
- 229910052760 oxygen Inorganic materials 0.000 title claims abstract description 176
- 239000012528 membrane Substances 0.000 title claims abstract description 49
- 238000000034 method Methods 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 210000004369 blood Anatomy 0.000 claims description 96
- 239000008280 blood Substances 0.000 claims description 96
- 239000007789 gas Substances 0.000 claims description 66
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 46
- 235000012489 doughnuts Nutrition 0.000 claims description 34
- 239000000835 fiber Substances 0.000 claims description 19
- 238000006213 oxygenation reaction Methods 0.000 claims description 14
- 238000004804 winding Methods 0.000 claims description 14
- 230000008859 change Effects 0.000 claims description 13
- 239000012510 hollow fiber Substances 0.000 claims description 11
- 230000017531 blood circulation Effects 0.000 claims description 9
- 238000009954 braiding Methods 0.000 claims description 9
- 239000003292 glue Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 8
- 238000003466 welding Methods 0.000 claims description 8
- 238000005538 encapsulation Methods 0.000 claims description 6
- 238000009434 installation Methods 0.000 claims description 6
- 210000001367 artery Anatomy 0.000 claims description 5
- 230000015572 biosynthetic process Effects 0.000 claims description 5
- -1 polypropylene Polymers 0.000 claims description 5
- 238000007789 sealing Methods 0.000 claims description 5
- 239000004743 Polypropylene Substances 0.000 claims description 4
- 238000009825 accumulation Methods 0.000 claims description 4
- 238000005520 cutting process Methods 0.000 claims description 4
- 229920000306 polymethylpentene Polymers 0.000 claims description 4
- 239000011116 polymethylpentene Substances 0.000 claims description 4
- 229920001155 polypropylene Polymers 0.000 claims description 4
- 229920000139 polyethylene terephthalate Polymers 0.000 claims description 3
- 239000005020 polyethylene terephthalate Substances 0.000 claims description 3
- 230000037452 priming Effects 0.000 abstract description 8
- 238000005516 engineering process Methods 0.000 abstract description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 6
- 238000010586 diagram Methods 0.000 description 5
- 210000004072 lung Anatomy 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 230000005587 bubbling Effects 0.000 description 4
- 239000004425 Makrolon Substances 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 239000001569 carbon dioxide Substances 0.000 description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 description 3
- 150000005690 diesters Chemical class 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 229920000515 polycarbonate Polymers 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- KKEYFWRCBNTPAC-UHFFFAOYSA-N Terephthalic acid Chemical compound OC(=O)C1=CC=C(C(O)=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000008676 import Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- KUCOHFSKRZZVRO-UHFFFAOYSA-N terephthalaldehyde Chemical compound O=CC1=CC=C(C=O)C=C1 KUCOHFSKRZZVRO-UHFFFAOYSA-N 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 1
- 206010058490 Hyperoxia Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 208000037849 arterial hypertension Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940078916 carbamide peroxide Drugs 0.000 description 1
- UBAZGMLMVVQSCD-UHFFFAOYSA-N carbon dioxide;molecular oxygen Chemical compound O=O.O=C=O UBAZGMLMVVQSCD-UHFFFAOYSA-N 0.000 description 1
- 230000002612 cardiopulmonary effect Effects 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000000280 densification Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000005242 forging Methods 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 230000000222 hyperoxic effect Effects 0.000 description 1
- 208000018875 hypoxemia Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 238000000059 patterning Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000002277 temperature effect Effects 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- MEYZYGMYMLNUHJ-UHFFFAOYSA-N tunicamycin Natural products CC(C)CCCCCCCCCC=CC(=O)NC1C(O)C(O)C(CC(O)C2OC(C(O)C2O)N3C=CC(=O)NC3=O)OC1OC4OC(CO)C(O)C(O)C4NC(=O)C MEYZYGMYMLNUHJ-UHFFFAOYSA-N 0.000 description 1
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1698—Blood oxygenators with or without heat-exchangers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/1623—Disposition or location of membranes relative to fluids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/12—Blood circulatory system
Abstract
The invention belongs to the field of medical instrument technology, and in particular to a kind of portable membrane oxygenator and preparation method and its oxygen close method.The membrane oxygenator closes pellicle group by shell, its components, mixing pellicle group and oxygen and forms, and its components are closed after pellicle group is installed in order and are fixed in enclosure cavity with mixing pellicle group and oxygen.The present invention solve membrane oxygenator oxygen close, alternating temperature efficiency it is low, structure is not close, and priming volume is big, generally pylindrical, and volume is larger, carries the technical problem such as inconvenience；Provide a kind of compact overall structure, oxygenator small volume, the portable membrane oxygenator easy to carry used and preparation method and its oxygen closes method.
Description
Technical field
The invention belongs to the field of medical instrument technology, and in particular to a kind of portable membrane oxygenator and preparation method and its
Oxygen closes method.
Background technology
Oxygen is few in the deposit of human body, and only continuously drawing oxygen from the external world can just sustain life normal fortune
OK.Routine clinical method for supplying oxygen method has nose conduit, hyperbaric oxygen chamber and Ventilators etc., but they all pass through respiratory tract
Toward conveying oxygen in vivo.For occurring causing pulmonary lesion, there is hypoxemia, lung compliance declines, gas interchange disturbance, lung
Patient's routine oxygen supply method of phenomena such as arterial hypertension is helpless.Need one kind to alleviate heart for this kind of patient to bear
Load, improves cardio-pulmonary function, repairs Heart and lungs injury, recovers the equipment of cardiac function.By ceaselessly studying oxygen carrying articles for use aspect,
The liquid oxygen charging method developed, including light quantum blood therapy (UIB), blood-magent therapy, magnesium arginyl amine hydroperoxide Carbamide Peroxide method,
Ultraviolet liquid irradiation etc., but be also respectively present blood drawing oxygenation and feed back the defects of operation is loaded down with trivial details, blood oxygen carrying content is few, stability is poor.
With the development of medical instrument, a kind of new oxygen supply treatment method applies to clinic, and this method can be of short duration or even 1 month maintains
Or nature lung work(is substituted, vim and vigour exchange is carried out, is a kind of heart-lung machine of improvement, is known as extracorporal circulatory system.Extracorporal circulatory system is
Internal blood is led into external progress oxygen conjunction, then again in defeated ex vivo, the carbon dioxide in blood is substituted for by oxygen by oxygenator
Gas, carbon dioxide is discharged.Domestic widely applied oxygenator is bubble oxygenator, its principle is sharp in a foaming bucket
Oxygen conjunction is carried out to blood with gas foaming principle, effect is poor, and security is relatively low the drawback is that oxygen closes.Diaphragm type oxygenator is gradual
Apply to clinic.Membrane oxygenator is by polymer matrix, by oxygen and carbon dioxide exchange.Pellicle is doughnut,
Interior flat external blood circulation.Clinical economics pattern at present, equipment is complicated, huge, and pipeline is various, priming volume is big, complicated, mobility
Difference.And scene is given treatment to, particularly battlefield or disaster environment inclement condition are, it is necessary to portable treatment device and quickly sue and labour, it is desirable to
Priming volume is small, easy to operate.Existing domestic membrane oxygenator oxygen closes, alternating temperature efficiency is low, and structure is not close, and priming volume is big, and one
As be cylinder, volume is larger, and generally not less than diameter 200MM, the cylinder of long 300MM sizes, it is inconvenient to carry.
The content of the invention
Goal of the invention：
In order to solve the above technical problems, the present invention provides a kind of compact overall structure, oxygenator small volume, use easy to carry
Portable membrane oxygenator and preparation method and its oxygen close method.
Technical solution：
The present invention is achieved through the following technical solutions：
A kind of portable membrane oxygenator, the oxygenator shell are integrally square, by shell, its components, mixing pellicle group
Pellicle group is closed with oxygen to form, and mixes pellicle group and oxygen closes pellicle group and is installed in its components, the inner cavity installation of shell
Its components；
Shell is made of shell I, shell II, shell III and shell IV；Shell I, shell II, shell III and shell IV welds or glue
Connect fixation；Gas outlet on air inlet on the shell I face shell III opposite with shell I, which connects, forms gas circuit chamber；On shell II
The water inlet face shell IV opposite with shell II on water outlet connect and form water route chamber；
Its components are followed successively by middle mesh sheet fixed in end cap I, shunting net I, supporting rack, supporting rack, shunting net II from front to back
With end cap II；The blood outlet of the blood inlet of end cap I and the face end cap II opposite with end cap I forms blood input and output chamber；Shunting
Net I, shunting net II and middle mesh sheet carry fine and closely woven mesh, and mixing pellicle group is fixed between shunting net I and middle mesh sheet；Middle net
Aerobic conjunction pellicle group is fixed between piece and shunting net II；Its components close pellicle group in order with mixing pellicle group and oxygen
It is fixed on after installation in enclosure cavity.
The portable membrane oxygenator, if oxygen closes pellicle group by the pourable rectangle of dried layer semipermeability gas
The oxygen of hollow fiber closes pellicle and forms, the oxygen of every layer of rectangular hollow fiber close pellicle relative to the oxygen of adjacent layer close pellicle with
90 degree of rotations stack, and oxygen, which closes pellicle, has the structure that wrought mat is wound in the winding single doughnut of bundle of lines；Mix semi-transparent
If film group by dried layer oxygen close pellicle with can heat exchange pellicle replace to be embedded in mutually and forms, every layer of oxygen conjunction pellicle is relative to phase
The doughnut of adjacent bed can heat exchange pellicle stacked with 90 degree of rotations.
The portable membrane oxygenator, it is polypropylene or polymethylpentene that oxygen, which closes pellicle its main component, often
Root doughnut length is 110 ~ 150mm, and braiding mat structure is wound in winding some doughnuts of bundle of lines；Can heat exchange half
For permeable membrane by the double-deck cross winding of heat exchange capillary use into braiding mat structure, heat exchange capillary is to use poly terephthalic acid second
Diester is made.
The portable membrane oxygenator, oxygen close pellicle group and are divided into mixing pellicle group in its components
Oxygenation chamber and oxygen are closed closes 0.7 ~ 1 square metre of effective area, effective alternating temperature face of heat exchange section with heat exchange mixing chamber, wherein oxygen
0.14 ~ 0.3 square metre of product.
The portable membrane oxygenator, the gas circuit chamber and water route chamber on shell are symmetrical two-by-two, air inlet and gas outlet
Set on shell III of the shell I with opposite face, air inlet is higher than gas outlet；Water inlet is with water outlet in shell II and opposite face
Shell IV on set, water inlet is higher than water outlet；Blood is flowed into from the blood inlet on end cap I, is evenly distributed to through shunting net I
Pellicle group is mixed, the change warm water with that can flow into from top to bottom in heat exchange pellicle doughnut carries out hot friendship in fiber surface
Change, afterwards blood again from oxygen close pellicle doughnut radial through, with oxygen close pellicle doughnut in oxygen pass through fibre
Fenestra on Wei Bi carries out gas exchanges；Last alternating temperature, oxygen close after blood by shunting net II, blood accumulation to together,
Oxygenator is left from blood outlet.
The portable membrane oxygenator, end cap I and end cap II have an artery exhaust outlet.
A kind of preparation method of portable membrane oxygenator,
Its preparation methods steps are as follows：
Step 1：Using method for hot cutting oxygen close pellicle and can heat exchange pellicle cut according to size；Oxygen closes half
The oxygen of permeable membrane group closes being stacked between layers with 90 degree of rotations for pellicle, and the oxygen of mixing pellicle group closes pellicle with that hot can hand over
Pellicle is changed to stack with 90 degree of rotations；
Step 2：Oxygen is closed into its components by pellicle group and mixing pellicle group embedding using multiple one side glue encapsulation method；
Step 3：Shell I, shell II, shell III and shell IV are prepared using integral formation method；
Step 4：The side of its components is secured the housing to using multiple single side glue sealing method or welding method.
A kind of oxygen of portable membrane oxygenator closes method,
It is as follows that its oxygen closes method and step：
Step 1：Blood enters oxygenator from the blood inlet of end cap I, and blood from bottom to top passes through shunting net I from mixing pellicle
Group radial through oxygen close with the change warm water that flows from top to bottom in heat exchange mixing chamber, with heat exchange capillary capillary surface into
Row heat exchange, while gas exchanges are carried out by the fenestra on fibre wall with the gas in doughnut；
Step 2：The oxygen that relents close after blood pass through again in mesh sheet close pellicle group radial through oxygenation chamber from oxygen, it is and hollow
Intrastitial gas carries out gas exchanges again by the fenestra on fibre wall；
Step 3：Blood after alternating temperature, oxygen conjunction leaves oxygenator by shunting net II by blood outlet；
Wherein, there is by flow sensor monitor the step of to measure blood flow；
There is by capnometer the step of to measure the gas concentration lwevel in gas.
Advantage and effect：
The invention has the advantages that and beneficial effect：
Compact overall structure, oxygenator small volume, overall volume are not more than 200*200*100mm, use easy to carry.With not
Saturating blood hollow fiber oxygenator integrates power oxygenation device with structure based on magnetic suspension centrifugal blood pump.The device is by by hyperoxia
The hollow fiber oxygenator and small-sized centrifugal blood pump device for closing efficiency are integrated.To realize in less volume and blood contacting surface
On the basis of product.Realize that oxygen closes and pump blood dual-use function by single device, adapt to give treatment to acute lung under complex environment to realize
Exhaustion personnel.
Improve alternating temperature efficiency：Blood is closed from front to back by oxygen through shunting net and heat exchange mixing chamber, then leads to from front to back
Oxygenation chamber is crossed, double-deck cross winding wrought mat occupation mode, can be such that blood is come into full contact with pellicle, maximize and improve oxygen conjunction
Alternating temperature efficiency.
Priming volume is small, and priming volume is not more than 300ml；Maximally utilize oxygen close pellicle and can heat exchange pellicle, oxygen close
0.7 ~ 1 ㎡ of effective area, 0.14 ~ 0.3 ㎡ of alternating temperature area, so that reduce whole oxygenator size, it is easy to carry.
Good row's bubbling ability.The type of flow of row's bubbling ability and blood has relation.Blood is through import, from the bottom up
Whole oxygenator is filled, exhaust outlet is located at the top of oxygenator, and apart from blood inlet farthest, both are apart from general 100mm, bubble
Discharge safer.
Shell is makrolon material, and the shell of surrounding is white, and end face is water white transparency, and internal structure is as it can be seen that can be with
It is clearly seen the process that blood carries out oxygen conjunction.
Water route and gas circuit are in the sagittal plane of blood flow, and bloody path separate management, can effectively prevent the blood tube of oxygenator
Pollute on road.
Compared with prior art, oxygen closes folded with 90 degree of rotations between pellicle group and the film layer and film layer that mix pellicle group
Put, oxygen is closed by pellicle group by encapsulation technology and mixing pellicle group is fixed with its components, limits blood flow scope
In its components, oxygenator is compact-sized, reduces the volume of oxygenator.
Brief description of the drawings
Fig. 1 is the schematic diagram according to the oxygenator module of the prior art；
Fig. 2 is the structure and material distribution schematic diagram that oxygen closes pellicle group；
Fig. 3 is the structure and material distribution schematic diagram of mixing pellicle group；
Fig. 4 is its components structure diagram；
Fig. 5 is shell mechanism schematic perspective view；
Fig. 6 rotates 180 degree schematic perspective view for shell mechanism；
Fig. 7 is braiding rectangle pellicle schematic diagram.
Description of reference numerals：
1. mix pellicle group；2. oxygen closes pellicle group；3. supporting rack；Mesh sheet in 4.；5. shunting net I；6. end cap I；
7. artery exhaust outlet；8. shell I；9. shell II；10. shell III；11. shell IV；12. air inlet；13. gas outlet；
14. water inlet；15. water outlet；16. blood inlet；17. blood outlet；18. oxygen closes pellicle；19. can heat exchange it is semi-transparent
Film；20. shunting net II；21. end cap II.
Embodiment
The present invention is described further below in conjunction with the accompanying drawings：
As shown in Figure 1, a kind of portable membrane oxygenator, which is integrally square, and by shell, its components, mixes
Closing pellicle group 1 and oxygen closes pellicle group 2 and forms, mixing pellicle group 1 and oxygen close pellicle group 2 and are installed in its components,
The inner cavity installation its components of shell；
Shell is made of shell I 8, shell II 9, shell III 10 and shell IV 11；Shell I 8, shell II 9, shell III
10 and shell IV 11 welding or be glued fix；On air inlet 12 on the shell I 8 face shell III 10 opposite with shell I 8
The connection of gas outlet 13 forms gas circuit chamber；Going out on water inlet 14 on the shell II 9 face shell IV 11 opposite with shell II 9
The connection of the mouth of a river 15 forms water route chamber；Shell is makrolon material, and the shell of surrounding is white, and end face is water white transparency, internal
Structure is visible, here it is apparent that blood carries out the process of oxygen conjunction；
As shown in figure 4, its components are followed successively by middle net fixed in end cap I, shunting net I, supporting rack 3, supporting rack 3 from front to back
Piece, shunting net II 20 and end cap II 21；The bleeding of the blood inlet 16 of end cap I 6 and the face end cap II 21 opposite with end cap I 6
Mouth 17 forms blood input and output chambers；Shunting net I 5, shunting net II 20 and middle mesh sheet carry fine and closely woven mesh, shunting net I 5
Mixing pellicle group 1 is fixed between middle mesh sheet；Aerobic conjunction pellicle group 2 is fixed between middle mesh sheet and shunting net II 20；It is interior
Core assembly is closed after pellicle group 2 is installed in order and is fixed in enclosure cavity with mixing pellicle group 1 and oxygen.Improve alternating temperature effect
Rate：Blood is closed from front to back by oxygen through shunting net and heat exchange mixing chamber, then from front to back by oxygenation chamber, bilayer, which intersects, to be twined
Around wrought mat occupation mode, as shown in fig. 7, blood can be made to be come into full contact with pellicle, maximize and improve oxygen conjunction alternating temperature efficiency.
As shown in Fig. 2, Fig. 3 and Fig. 7, the portable membrane oxygenator, if oxygen conjunction pellicle group 2 is semi-permeable by dried layer
Property the pourable rectangular hollow fiber of gas oxygen close pellicle 18 and form, the oxygen of every layer of rectangular hollow fiber closes 18 phase of pellicle
Stacked for the oxygen conjunction pellicle 18 of adjacent layer with 90 degree of rotations in the same direction, oxygen closes pellicle 18 with single hollow with winding bundle of lines
Fiber is wound in the structure of wrought mat；If mixing pellicle group 1 by dried layer oxygen close pellicle 18 with can heat exchange pellicle 19 hand over
Formed for mutual embedded, every layer of oxygen close pellicle 18 relative to adjacent layer doughnut can heat exchange pellicle 19 with the same direction 90
Degree rotation stacks.
Existing oxygenator is generally pylindrical, and compared with prior art, oxygen closes pellicle group and mixes the film of pellicle group
Stacked between layer and film layer with 90 degree of rotations, oxygen is closed by pellicle group and mixing pellicle group and its components by encapsulation technology
It is fixed, blood flow scope is limited in its components, oxygenator is compact-sized, reduces the volume of oxygenator.Every layer hollow
Fiber is rectangular, and after laminated multi-layer, formation intermediate region is prominent, intensive, the relatively thin phenomenon of surrounding, so that the intermembranous nothing in intermediate layer
Gap, each side are easier to be lived by embedding.
The portable membrane oxygenator, it is polypropylene or polymethylpentene that oxygen, which closes pellicle 18 its main component,
Every doughnut length is 110 ~ 150mm, and braiding mat structure is wound in winding some doughnuts of bundle of lines；Can heat exchange
For pellicle 19 by the double-deck cross winding of heat exchange capillary use into braiding mat structure, heat exchange capillary is with poly- terephthaldehyde
Sour second diester is made.
The portable membrane oxygenator, oxygen close pellicle group 2 and are divided with mixing pellicle group 1 in its components
For oxygenation chamber and oxygen closes and heat exchange mixing chamber, and wherein oxygen closes 0.7 ~ 1 square metre of effective area, effective alternating temperature of heat exchange section
0.14 ~ 0.3 square metre of area.Priming volume is small, and priming volume is not more than 300ml；Oxygenation membrane and heat exchange membranes are maximally utilized, oxygen closes
0.7 ~ 1 ㎡ of effective area, 0.14 ~ 0.3 ㎡ of alternating temperature area, so that reduce whole oxygenator size, it is easy to carry.
As shown in Figure 5 and Figure 6, the portable membrane oxygenator, the gas circuit chamber and water route chamber on shell are symmetrical two-by-two,
Air inlet 12 is set with gas outlet 13 on shell III 10 of the shell I 8 with opposite face, and air inlet 12 is higher than gas outlet 13；Into
The mouth of a river 14 is set with water outlet 15 on shell IV 11 of the shell II 9 with opposite face, and water inlet 14 is higher than water outlet 15；Blood
Flowed into from the blood inlet 16 on end cap I 6, mixing pellicle group 1 is evenly distributed to through shunting net I 5, and can heat exchange pellicle
The change warm water flowed into from top to bottom in 19 doughnuts carries out heat exchange in fiber surface, and blood closes pellicle 18 from oxygen again afterwards
Doughnut is radial through the oxygen closed with oxygen in 18 doughnut of pellicle carries out gas friendship by the fenestra on fibre wall
Change；Blood after last alternating temperature, oxygen conjunction, blood accumulation to together, is left oxygen from blood outlet 17 and closed by shunting net II 20
Device.Water route and gas circuit with bloody path separate management, can effectively prevent that the transducer potector of oxygenator is dirty in the sagittal plane of blood flow
Dye.
The portable membrane oxygenator, end cap I 6 and end cap II 21 have an artery exhaust outlet 7.Have oxygenator
There is good row's bubbling ability.The type of flow of row's bubbling ability and blood has relation.Blood is filled whole from the bottom up through import
A oxygenator, exhaust outlet are located at the top of oxygenator, and apart from blood inlet farthest, both discharge more apart from general 100mm, bubble
Safety.
A kind of preparation method of portable membrane oxygenator,
Its preparation methods steps are as follows：
Step 1：Using method for hot cutting oxygen close pellicle 18 and can heat exchange pellicle 19 cut according to size；Oxygen
The oxygen for closing pellicle group 2 closes being stacked between layers with 90 degree of rotations for pellicle 18, and the oxygen of mixing pellicle group 1 closes pellicle
18 with can heat exchange pellicle 19 stacked with 90 degree of rotations；
Wherein its components are prepared by the method that casting or machine add；
Step 2：Oxygen is closed to its components by pellicle group 2 and 1 embedding of mixing pellicle group using multiple one side glue encapsulation method
In；
Step 3：Shell I 8, shell II 9, shell III 10 and shell IV 11 are prepared using integral formation method；
Step 4：Its components side is secured the housing to using multiple single side glue sealing method or welding method.
A kind of oxygen of portable membrane oxygenator closes method,
It is as follows that its oxygen closes method and step：
Step 1：Blood enters oxygenator from the blood inlet 16 of end cap I 6, and blood from bottom to top passes through shunting net I 5 from mixing
Pellicle group 1 is closed with the change warm water flowed from top to bottom in heat exchange mixing chamber, with heat exchange capillary in capillary radial through oxygen
Pipe surface carries out heat exchange, while carries out gas exchanges by the fenestra on fibre wall with the gas in doughnut；
Step 2：The oxygen that relents close after blood pass through again in mesh sheet close pellicle group 2 radial through oxygenation chamber from oxygen, it is and hollow
Intrastitial gas carries out gas exchanges again by the fenestra on fibre wall；
Step 3：Blood after alternating temperature, oxygen conjunction leaves oxygenator by shunting net II 20 by blood outlet 17；
Wherein, there is by flow sensor monitor the step of to measure blood flow；
There is by capnometer the step of to measure the gas concentration lwevel in gas.
Embodiment 1：
As shown in Figure 1, a kind of portable membrane oxygenator, which is integrally square, and by shell, its components, mixes
Closing pellicle group 1 and oxygen closes pellicle group 2 and forms, mixing pellicle group 1 and oxygen close pellicle group 2 and are installed in its components,
The inner cavity installation its components of shell；
Shell is made of shell I 8, shell II 9, shell III 10 and shell IV 11；Shell I 8, shell II 9, shell III
10 and shell IV 11 welding or be glued fix；On air inlet 12 on the shell I 8 face shell III 10 opposite with shell I 8
The connection of gas outlet 13 forms gas circuit chamber；Going out on water inlet 14 on the shell II 9 face shell IV 11 opposite with shell II 9
The connection of the mouth of a river 15 forms water route chamber；
As shown in figure 4, its components are followed successively by middle net fixed in end cap I, shunting net I, supporting rack 3, supporting rack 3 from front to back
Piece, shunting net II 20 and end cap II 21；The bleeding of the blood inlet 16 of end cap I 6 and the face end cap II 21 opposite with end cap I 6
Mouth 17 forms blood input and output chambers；Shunting net I 5, shunting net II 20 and middle mesh sheet carry fine and closely woven mesh, shunting net I 5
Mixing pellicle group 1 is fixed between middle mesh sheet；Aerobic conjunction pellicle group 2 is fixed between middle mesh sheet and shunting net II 20；It is interior
Core assembly is closed after pellicle group 2 is installed in order and is fixed in enclosure cavity with mixing pellicle group 1 and oxygen.
Blood enters oxygenator from the blood inlet 16 of end cap I 6, and blood is from bottom to top semi-transparent from mixing by shunting net I 5
Film group 1 is closed with the change warm water flowed from top to bottom in heat exchange mixing chamber, with heat exchange capillary in capillary sheet radial through oxygen
Face carries out heat exchange, while carries out gas exchanges by the fenestra on fibre wall with the gas in doughnut；
Mesh sheet closes pellicle group 2 radial through in oxygenation chamber, with doughnut from oxygen during blood after the oxygen that relents conjunction passes through again
Gas carried out again by the fenestra on fibre wall gas exchanges alternating temperature, oxygen close after blood pass through by shunting net II 20
Blood outlet 17 leaves oxygenator.
Embodiment 2：
A kind of preparation method of portable membrane oxygenator,
Its preparation methods steps are as follows：
Step 1：Using method for hot cutting oxygen close pellicle 18 and can heat exchange pellicle 19 cut according to size；Oxygen
The oxygen for closing pellicle group 2 closes being stacked between layers with 90 degree of rotations for pellicle 18, and the oxygen of mixing pellicle group 1 closes pellicle
18 with can heat exchange pellicle 19 stacked with 90 degree of rotations；
Its components carry out patterning process using die sinking forging type to makrolon material；
Step 2：Oxygen is closed to its components by pellicle group 2 and 1 embedding of mixing pellicle group using multiple one side glue encapsulation method
In；
Step 3：Shell I 8, shell II 9, shell III 10 and shell IV 11 are prepared using integral formation method；
Step 4：Its components side is secured the housing to using multiple single side glue sealing method or welding method.
As shown in Figure 1, a kind of portable membrane oxygenator, which is integrally square, by shell, inner core group
Part, mixing pellicle group 1 and oxygen close pellicle group 2 and form, and mixing pellicle group 1 and oxygen close pellicle group 2 and is installed on inner core group
In part, the inner cavity installation its components of shell；
Shell is made of shell I 8, shell II 9, shell III 10 and shell IV 11；Shell I 8, shell II 9, shell III
10 and shell IV 11 welding or be glued fix；On air inlet 12 on the shell I 8 face shell III 10 opposite with shell I 8
The connection of gas outlet 13 forms gas circuit chamber；Going out on water inlet 14 on the shell II 9 face shell IV 11 opposite with shell II 9
The connection of the mouth of a river 15 forms water route chamber；
As shown in figure 4, its components are followed successively by middle net fixed in end cap I, shunting net I, supporting rack 3, supporting rack 3 from front to back
Piece, shunting net II 20 and end cap II 21；The bleeding of the blood inlet 16 of end cap I 6 and the face end cap II 21 opposite with end cap I 6
Mouth 17 forms blood input and output chambers；Shunting net I 5, shunting net II 20 and middle mesh sheet carry fine and closely woven mesh, shunting net I 5
Mixing pellicle group 1 is fixed between middle mesh sheet；Aerobic conjunction pellicle group 2 is fixed between middle mesh sheet and shunting net II 20；It is interior
Core assembly is closed after pellicle group 2 is installed in order and is fixed in enclosure cavity with mixing pellicle group 1 and oxygen.
As shown in Fig. 2, Fig. 3 and Fig. 7, the portable membrane oxygenator, oxygen closes pellicle group 2 by 60 layers of semipermeability
The oxygen of the pourable rectangular hollow fiber of gas closes pellicle 18 and forms, and the oxygen conjunction pellicle 18 of every layer of rectangular hollow fiber is opposite
Pellicle 18 is closed in the oxygen of adjacent layer to stack with 90 degree of rotations, oxygen conjunction pellicle 18 has to be twined with the winding single doughnut of bundle of lines
It is coiled into the structure of wrought mat；Mixing pellicle group 1 by 15 layers of oxygen close pellicles 18 with 15 layers can heat exchange pellicle 19 replace mutually
It is mutually embedded to form, every layer of oxygen close pellicle 18 relative to adjacent layer doughnut can heat exchange pellicle 19 folded with 90 degree rotations
Put.
Oxygen closes pellicle group and generally selects oxygen to close pellicle between 100 to 10 layers, mixes and is generally selected in pellicle group
Oxygen close pellicle between 50 to 5 layers, while can heat exchange pellicle generally also select 50 to 5 layers between, which can be most
Bigization using oxygen close pellicle and can heat exchange pellicle, oxygen close 0.7 ~ 1 ㎡ of effective area, 0.14 ~ 0.3 ㎡ of alternating temperature area, from
And reduce whole oxygenator size, it is easy to carry.
The portable membrane oxygenator, it is polypropylene or polymethylpentene that oxygen, which closes pellicle 18 its main component,
Every doughnut length is 110 ~ 150mm, and braiding mat structure is wound in winding some doughnuts of bundle of lines；Can heat exchange
For pellicle 19 by the double-deck cross winding of heat exchange capillary use into braiding mat structure, heat exchange capillary is with poly- terephthaldehyde
Sour second diester is made.Per tunic width in 85 ~ 110mm.Oxygen, which closes pellicle 18, can make the impermeable blood plasma of pellicle.Oxygen closes pellicle
With uniform more pore size distributions, while there is the exocuticle of densification, film can complete neutralizing liquid, such as blood plasma or water, thoroughly
Via structure, even if being exposed to for a long time in these liquid, will not be permeated hence into the inner cavity of capillary.This
Kind film can avoid blood（Capillary exterior measuring）With air or oxygen（On the inside of capillary）Directly contact, therefore help to reduce
To the pressure of blood.Oxygen, which closes pellicle, has remarkable diffusion, and gas such as oxygen, carbon dioxide pass through the conduction of capillary wall
It will not be hindered be subject to exocuticle.
Heat exchange capillary is to use polyethylene terephthalate（PET）It is made, is sealing, a transparent, non-porous hair
Tubule, has impenetrability to blood and water.Gas can be a little by diffusing through the capillary wall of closing, can be well
Transmit temperature.Can heat exchange pellicle mat structure is woven using double-deck cross winding, make full use of the contact area with blood, into
Row is maximized to be exchanged.
The portable membrane oxygenator, oxygen close pellicle group 2 and are divided with mixing pellicle group 1 in its components
For oxygenation chamber and oxygen closes and heat exchange mixing chamber, and wherein oxygen closes 0.7 ~ 1 square metre of effective area, effective alternating temperature of heat exchange section
0.14 ~ 0.3 square metre of area.
As shown in Figure 5 and Figure 6, the portable membrane oxygenator, the gas circuit chamber and water route chamber on shell are symmetrical two-by-two,
Air inlet 12 is set with gas outlet 13 on shell III 10 of the shell I 8 with opposite face, and air inlet 12 is higher than gas outlet 13；Into
The mouth of a river 14 is set with water outlet 15 on shell IV 11 of the shell II 9 with opposite face, and water inlet 14 is higher than water outlet 15；Blood
Flowed into from the blood inlet 16 on end cap I 6, mixing pellicle group 1 is evenly distributed to through shunting net I 5, and can heat exchange pellicle
The change warm water flowed into from top to bottom in 19 doughnuts carries out heat exchange in fiber surface, and blood closes pellicle 18 from oxygen again afterwards
Doughnut is radial through the oxygen closed with oxygen in 18 doughnut of pellicle carries out gas friendship by the fenestra on fibre wall
Change；Blood after last alternating temperature, oxygen conjunction, blood accumulation to together, is left oxygen from blood outlet 17 and closed by shunting net II 20
Device.
The portable membrane oxygenator, end cap I 6 and end cap II 21 have an artery exhaust outlet 7.
A kind of oxygen of portable membrane oxygenator closes method,
It is as follows that its oxygen closes method and step：
Step 1：Blood enters oxygenator from the blood inlet 16 of end cap I 6, and blood from bottom to top passes through shunting net I 5 from mixing
Pellicle group 1 is closed with the change warm water flowed from top to bottom in heat exchange mixing chamber, with heat exchange capillary in capillary radial through oxygen
Pipe surface carries out heat exchange, while carries out gas exchanges by the fenestra on fibre wall with the gas in doughnut；
Step 2：The oxygen that relents close after blood pass through again in mesh sheet close pellicle group 2 radial through oxygenation chamber from oxygen, it is and hollow
Intrastitial gas carries out gas exchanges again by the fenestra on fibre wall；
Step 3：Blood after alternating temperature, oxygen conjunction leaves oxygenator by shunting net II 20 by blood outlet 17；
Wherein, there is by flow sensor monitor the step of to measure blood flow；
There is by capnometer the step of to measure the gas concentration lwevel in gas.
The parameter comparison such as table 1 of portable membrane oxygenator and existing oxygenator：
The table of comparisons of 1 portable oxygen of table and existing oxygenator
Claims (8)
- A kind of 1. portable membrane oxygenator, it is characterised in that：The oxygenator shell is integrally square, by shell, its components, Mix pellicle group（1）Pellicle group is closed with oxygen（2）Form, mix pellicle group（1）Pellicle group is closed with oxygen（2）Installed in interior In core assembly, the inner cavity installation its components of shell；Shell is by shell I（8）, shell II（9）, shell III（10）With shell IV（11）Form；Shell I（8）, shell II（9）, it is outer Shell III（10）With shell IV（11）Fixation is glued in welding；Shell I（8）On air inlet（12）With shell I（8）Outside opposite face Shell III（10）On gas outlet（13）Connection forms gas circuit chamber；Shell II（9）On water inlet（14）With shell II（9）Opposite Face shell IV（11）On water outlet（15）Connection forms water route chamber；Its components are followed successively by end cap I, shunting net I, supporting rack from front to back（3）, supporting rack（3）The middle mesh sheet of middle fixation（4）、 Shunting net II（20）With end cap II（21）；End cap I（6）Blood inlet（16）With with end cap I（6）Opposite face end cap II（21）'s Blood outlet（17）Form blood input and output chamber；Shunting net I（5）, shunting net II（20）Fine and closely woven mesh is carried with middle mesh sheet, point Drift net I（5）Mixing pellicle group is fixed between middle mesh sheet（1）；Middle mesh sheet and shunting net II（20）Between fix aerobic conjunction Pellicle group（2）；Its components are with mixing pellicle group（1）Pellicle group is closed with oxygen（2）Shell is fixed on after installing in order In cavity.
- 2. portable membrane oxygenator according to claim 1, it is characterised in that：Oxygen closes pellicle group（2）If by dried layer The oxygen of the pourable rectangular hollow fiber of semipermeability gas closes pellicle（18）Form, the oxygen of every layer of rectangular hollow fiber closes half Permeable membrane（18）Pellicle is closed relative to the oxygen of adjacent layer（18）Stacked with 90 degree of rotations, oxygen closes pellicle（18）With with winding line Single doughnut is wound in the structure of wrought mat；Mix pellicle group（1）If pellicle is closed by dried layer oxygen（18）With can heat Exchange pellicle（19）Alternately embedded mutually to form, every layer of oxygen closes pellicle（18）Can heat friendship relative to the doughnut of adjacent layer Change pellicle（19）Stacked with 90 degree of rotations.
- 3. portable membrane oxygenator according to claim 2, it is characterised in that：Oxygen closes pellicle（18）Its main component For polypropylene or polymethylpentene, every doughnut length is 110 ~ 150mm, is twined with winding some doughnuts of bundle of lines It is coiled into braiding mat structure；Can heat exchange pellicle（19）By heat exchange capillary using double-deck cross winding into braiding mat structure, Heat exchange capillary is made of polyethylene terephthalate.
- 4. portable membrane oxygenator according to claim 1 or 2, it is characterised in that：Oxygen closes pellicle group（2）With mixing Pellicle group（1）It is divided into oxygenation chamber in its components and oxygen closes and closes effective area 0.7 with heat exchange mixing chamber, wherein oxygen ~ 1 square metre, 0.14 ~ 0.3 square metre of effective alternating temperature area of heat exchange section.
- 5. portable membrane oxygenator according to claim 1, it is characterised in that：Gas circuit chamber and water route chamber two on shell Two is symmetrical, air inlet（12）With gas outlet（13）In shell I（8）With the shell III of opposite face（10）Upper setting, air inlet（12） Higher than gas outlet（13）；Water inlet（14）With water outlet（15）In shell II（9）With the shell IV of opposite face（11）Upper setting, into The mouth of a river（14）Higher than water outlet（15）；Blood is from end cap I（6）On blood inlet（16）Flow into, through shunting net I（5）It is uniformly distributed To mixing pellicle group（1）, and can heat exchange pellicle（19）The change warm water flowed into from top to bottom in doughnut is in fiber table Face carries out heat exchange, and blood closes pellicle from oxygen again afterwards（18）Doughnut is radial through with oxygen conjunction pellicle（18）It is hollow Intrastitial oxygen carries out gas exchanges by the fenestra on fibre wall；Blood after last alternating temperature, oxygen conjunction passes through shunting net II （20）, blood accumulation to together, from blood outlet（17）Leave oxygenator.
- 6. portable membrane oxygenator according to claim 1, it is characterised in that：End cap I（6）With end cap II（21）Have One artery exhaust outlet（7）.
- A kind of 7. preparation method of portable membrane oxygenator, it is characterised in that：Its preparation methods steps are as follows：Step 1：Oxygen is closed using method for hot cutting by pellicle（18）With can heat exchange pellicle（19）Cut according to size Cut；Oxygen closes pellicle group（2）Oxygen close pellicle（18）Stacked between layers with 90 degree of rotations, mix pellicle group（1） Oxygen close pellicle（18）With can heat exchange pellicle（19）Stacked with 90 degree of rotations；Step 2：Oxygen is closed by pellicle group using multiple one side glue encapsulation method（2）With mixing pellicle group（1）Embedding is to inner core group In part；Step 3：Shell I is prepared using integral formation method（8）, shell II（9）, shell III（10）With shell IV（11）；Step 4：The side of its components is secured the housing to using multiple single side glue sealing method or welding method.
- 8. a kind of oxygen of portable membrane oxygenator closes method, it is characterised in that：It is as follows that its oxygen closes method and step：Step 1：Blood is from end cap I（6）Blood inlet（16）Into oxygenator, blood from bottom to top passes through shunting net I（5）From Mix pellicle group（1）The change warm water with being flowed from top to bottom in heat exchange mixing chamber, with heat exchange capillary is closed radial through oxygen Heat exchange is carried out in capillary surface, while gas exchanges are carried out by the fenestra on fibre wall with the gas in doughnut；Step 2：Mesh sheet during blood after the oxygen that relents conjunction passes through again（4）Pellicle group is closed from oxygen（2）Radial through oxygenation chamber, Gas exchanges are carried out by the fenestra on fibre wall again with the gas in doughnut；Step 3：Blood after alternating temperature, oxygen conjunction passes through shunting net II（20）Pass through blood outlet（17）Leave oxygenator；Wherein, there is by flow sensor monitor the step of to measure blood flow；There is by capnometer the step of to measure the gas concentration lwevel in gas.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109091713A (en) * | 2018-08-21 | 2018-12-28 | 上海鑫笃龙医疗器械有限公司 | A kind of integral type extracorporeal life support system |
| CN109364314A (en) * | 2018-12-07 | 2019-02-22 | 江苏美思康医疗科技有限公司 | A kind of two-chamber membrane oxygenator and oxygen close method |
| CN110575579A (en) * | 2019-09-23 | 2019-12-17 | 中国科学技术大学 | Dialysis-enhanced hemodialyzer capable of improving blood flow |
| WO2020155236A1 (en) * | 2019-01-31 | 2020-08-06 | 江苏赛腾医疗科技有限公司 | Monitoring host and cardiopulmonary bypass system |
| CN111992053A (en) * | 2020-08-17 | 2020-11-27 | 杭州科百特科技有限公司 | Gas exchange membrane, preparation method thereof and gas exchange assembly |
| CN112007519A (en) * | 2020-08-17 | 2020-12-01 | 杭州科百特科技有限公司 | Oxygenation membrane, preparation method thereof and oxygenation assembly |
| CN116271306A (en) * | 2023-05-24 | 2023-06-23 | 北京清瀚医疗科技有限公司 | Polygonal artificial membrane lung for in-vitro carbon dioxide removal and preparation method thereof |
| CN117339043A (en) * | 2023-12-06 | 2024-01-05 | 北京航天长峰股份有限公司 | Membrane type oxygenator |
| WO2024058776A1 (en) * | 2022-09-14 | 2024-03-21 | Vitara Biomedical, Inc. | Oxygenator for neonates |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109091713A (en) * | 2018-08-21 | 2018-12-28 | 上海鑫笃龙医疗器械有限公司 | A kind of integral type extracorporeal life support system |
| CN109364314A (en) * | 2018-12-07 | 2019-02-22 | 江苏美思康医疗科技有限公司 | A kind of two-chamber membrane oxygenator and oxygen close method |
| CN109364314B (en) * | 2018-12-07 | 2023-10-24 | 江苏美思康医疗科技有限公司 | Double-cavity membrane type oxygenator and oxygenation method |
| WO2020155236A1 (en) * | 2019-01-31 | 2020-08-06 | 江苏赛腾医疗科技有限公司 | Monitoring host and cardiopulmonary bypass system |
| CN110575579A (en) * | 2019-09-23 | 2019-12-17 | 中国科学技术大学 | Dialysis-enhanced hemodialyzer capable of improving blood flow |
| CN111992053A (en) * | 2020-08-17 | 2020-11-27 | 杭州科百特科技有限公司 | Gas exchange membrane, preparation method thereof and gas exchange assembly |
| CN112007519A (en) * | 2020-08-17 | 2020-12-01 | 杭州科百特科技有限公司 | Oxygenation membrane, preparation method thereof and oxygenation assembly |
| WO2024058776A1 (en) * | 2022-09-14 | 2024-03-21 | Vitara Biomedical, Inc. | Oxygenator for neonates |
| CN116271306A (en) * | 2023-05-24 | 2023-06-23 | 北京清瀚医疗科技有限公司 | Polygonal artificial membrane lung for in-vitro carbon dioxide removal and preparation method thereof |
| CN116271306B (en) * | 2023-05-24 | 2024-03-12 | 北京清瀚医疗科技有限公司 | Polygonal artificial membrane lung for in-vitro carbon dioxide removal and preparation method thereof |
| CN117339043A (en) * | 2023-12-06 | 2024-01-05 | 北京航天长峰股份有限公司 | Membrane type oxygenator |
| CN117339043B (en) * | 2023-12-06 | 2024-03-12 | 北京航天长峰股份有限公司 | Membrane type oxygenator |
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