CN105396187B - A kind of extracorporeal membrane oxygenation device - Google Patents
A kind of extracorporeal membrane oxygenation device Download PDFInfo
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- CN105396187B CN105396187B CN201511016962.7A CN201511016962A CN105396187B CN 105396187 B CN105396187 B CN 105396187B CN 201511016962 A CN201511016962 A CN 201511016962A CN 105396187 B CN105396187 B CN 105396187B
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- channel
- blood
- exchange units
- gas exchange
- oxygenation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/1623—Disposition or location of membranes relative to fluids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1698—Blood oxygenators with or without heat-exchangers
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- Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
The present invention provides a kind of extracorporeal membrane oxygenation device, including：Shell, inside form oxygenation chamber, have blood channel and blood inlet, blood outlet positioned at the blood channel both ends in the oxygenation chamber；Also there is oxygen channel and the air inlet positioned at the oxygen channel both ends, gas outlet in the oxygenation chamber；At least two groups gas exchange units, predetermined shape is woven by polymer fiber tubing, and it is fixed in the oxygenation chamber close to the blood channel and the gas passage simultaneously, so that the oxygen in the gas passage can enter in the blood channel through the gas exchange units, the setting of two groups of gas exchange units is so that during the manufacturing, the length of used single fiber pipe can reduce half, to reduce the technology difficulty of the manufacturing, be conducive to for fibre pipe to be woven into scheduled shape.
Description
Technical field
The present invention relates to the field of medical instrument technology, and in particular to a kind of extracorporeal membrane oxygenation oxygenator structure.
Background technique
Extracorporeal membrane oxygenation technology (ECMO) is " artificial lung " established other than human body, primarily serves part lung function substitution
Effect, lung function is supported on the basis of not aggravating protopathy, allows organ to do self-regeneration by the effect of extracorporal circulatory system, is maintained
Human internal organ tissue oxygenation blood supply, so that the sign that effectively sustains life, is damaged internal organs for successive treatment and provides time enough.Oxygen
Clutch is the core devices that Portable lung function supports device.
The gas that monoblock type is usually provided in the oxygenation chamber of the currently used oxygenator for external Breathing Suppotion is handed over
Unit is changed, a kind of portable pump-free type extracorporeal membrane oxygenator, this oxygenator as disclosed in Chinese patent CN202459508U
There are following technological deficiencies：Since gas exchange units use integral structure, in this way for being woven into gas exchange units
Single fiber pipe must just have enough length, and Zhong row repeatedly bends and weaves, and so allow for the difficulty of processing technology
It increases, reduces yields, increase production cost.
Summary of the invention
Therefore, the technical problem to be solved in the present invention is that overcoming extracorporeal membrane oxygenation device processing technology in the prior art difficult
Degree is high, the technological deficiency of high production cost.
In order to solve the above technical problems, the present invention provides a kind of extracorporeal membrane oxygenation device, including：
Shell, inside form oxygenation chamber, have blood channel in the oxygenation chamber and positioned at the blood channel both ends
Zhong blood mouth, blood outlet；Also there is oxygen channel and Zhong port, outlet positioned at the oxygen channel both ends in the oxygenation chamber
Mouthful；
At least two groups gas exchange units are woven into predetermined shape by polymer fiber tubing, and simultaneously close to the blood
Liquid channel and the gas passage are fixed in the oxygenation chamber, so that the oxygen in the gas passage can penetrate institute
Gas exchange units Zhong is stated to enter into the blood channel.
In above-mentioned extracorporeal membrane oxygenation device, the blood channel include be arranged in the oxygenation chamber side Zhong blood channel and
Positioned at the bleeding channel of the oxygenation chamber other side, and the interface channel in connection Zhong blood channel and the bleeding channel；
The gas exchange units are two groups, and are arranged respectively around Zhong blood channel and the bleeding channel.
In above-mentioned extracorporeal membrane oxygenation device, the oxygenation chamber is regular hexagon；
Several equilateral triangle structure compositions that the gas exchange units are woven by the polymer fiber tubing are just
Hexagonal structure.
In above-mentioned extracorporeal membrane oxygenation device, further include connect every group at top described in gas exchange units encapsulating housing,
The encapsulating housing connects gas exchange units described in several groups integral.
In above-mentioned extracorporeal membrane oxygenation device, the oxygen channel is set between Zhong blood channel and the bleeding channel
It sets, and the Zhong port is located at the bottom of the oxygenation chamber；The gas outlet is two, and is located at the two of the oxygenation chamber
Side.
In above-mentioned extracorporeal membrane oxygenation device, the shell further includes inner casing and the shell for wrapping up the inner casing setting；
The both ends of the inner casing and the shell use resin seal.
It further include the bubble eliminating structure for eliminating bubble in the blood channel in above-mentioned extracorporeal membrane oxygenation device,
The bubble eliminating structure includes：Extend at from the resin of the upper shell into the oxygenation chamber, and is connected to the connection
The bubble in channel eliminates channel.
Detailed description of the invention
It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution in the prior art
Embodiment or attached drawing needed to be used in the description of the prior art be briefly described, it should be apparent that, it is described below
Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor
It puts, is also possible to obtain other drawings based on these drawings.
Fig. 1 is the schematic cross-sectional view of oxygenator of the invention；
Fig. 2 is the main view of oxygenator of the invention；
Fig. 3 is the structural schematic diagram of gas exchange units in the present invention.
Description of symbols：
10- shell；111- Zhong blood mouth；121- blood outlet；131- Zhong port；The gas outlet 132-；20- gas exchange units；
11- Zhong blood channel；12- bleeding channel；13- interface channel；30- encapsulating housing；14- inner casing；15- shell；16- bubble is eliminated logical
Road.
Specific embodiment
Technical solution of the present invention Zhong row is clearly and completely described below in conjunction with attached drawing, it is clear that described implementation
Example is a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill
Personnel's every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that term " center ", "upper", "lower", "left", "right", "vertical",
The orientation or positional relationship of the instructions such as "horizontal", "inner", "outside" be based on the orientation or positional relationship shown in the drawings, merely to
Convenient for description the present invention and simplify description, rather than the device or element of indication or suggestion meaning must have a particular orientation,
It is constructed and operated in a specific orientation, therefore is not considered as limiting the invention.In addition, term " first ", " second ",
" third " is used for descriptive purposes only and cannot be understood as indicating or suggesting relative importance.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or be integrally connected；It can
To be mechanical connection, it is also possible to be electrically connected；It can be directly connected, can also can be indirectly connected through an intermediary
Connection inside two elements.For the ordinary skill in the art, specifically above-mentioned term can be understood at this by feelings Saeka
Concrete meaning in invention.
As long as in addition, the non-structure each other of technical characteristic involved in invention described below different embodiments
It can be combined with each other at conflict.
Embodiment 1
With reference to Fig. 1 and Fig. 2, the present embodiment provides a kind of extracorporeal membrane oxygenation devices, including：Shell 10 and gas exchange units
20, the inside of shell 10 forms oxygenation chamber, has blood channel and the Zhong blood mouth positioned at the blood channel both ends in oxygenation chamber
111, blood outlet 121；Also there is oxygen channel and the Zhong port 131 positioned at the oxygen channel both ends, gas outlet in oxygenation chamber
132.In actual use, blood and oxygen pass through blood channel and oxygen channel respectively simultaneously, and the oxygen in oxygen channel is saturating
It crosses in the blood that 20 Zhong of gas exchange units enters into blood channel, the carbon dioxide in blood then penetrates gas from blood channel
20 Zhong of crosspoint enters to oxygen channel, and is discharged from gas outlet 132.The gas exchanges list that existing oxygenator generallys use
Member is integral, and this design method makes the length for constituting the single fiber pipe of gas exchange units longer, on the one hand with benefit
In braiding, increase the technology difficulty manufactured；Meanwhile but also yields decreases, production cost is in a disguised form improved.
As a preferred embodiment, two groups of gas exchange units 20 are provided in oxygenation chamber, by polymer fiber
Tubing is woven into predetermined shape, and is fixed at the oxygenation chamber close to the blood channel and the gas passage simultaneously
Interior, more preferable two groups of gas exchange units 20 are arranged around Zhong blood channel 11 and the bleeding channel 12 respectively, so that institute
Stating the oxygen in gas passage can enter through 20 Zhong of gas exchange units into the blood channel, two groups of gas exchanges
So that during the manufacturing, the length of used single fiber pipe can reduce half for the setting of unit 20, thus
The technology difficulty for reducing the manufacturing is conducive to for fibre pipe to be woven into scheduled shape.
As a preference, the adjacent fiber pipe in gas exchange units 20 is preferably woven into equilateral triangle with reference to Fig. 3,
Multiple equilateral triangles are arranged successively again to constitute regular hexagon structure.The gas exchange units 20 of regular hexagon structure can be with
Blood flow dead angle effectively is avoided, keeps gas exchanges more abundant.
It should be noted that the quantity of gas exchange units 20 is preferably but not limited to be two groups in the present embodiment, this field
Technical staff can be in conjunction with above description, and the quantity to gas exchange units 20 and the specific set-up mode in oxygenation chamber are made
The modification of certain adaptability, but it is covered by the protection scope of the present invention.
The specific set-up mode of the extracorporeal membrane oxygenation device of the present embodiment is described in detail below in conjunction with Fig. 1 and Fig. 2：
Referring initially to Fig. 1, shell 10 includes inner casing 14 and wraps up the shell 15 that inner casing 14 is arranged, inner casing 15 and shell 14
Both ends use resin seal, Zhong blood mouth 111, blood outlet 121, Zhong port 131, gas outlet 132, be separately positioned on shell 14 or
It is at resin seal, the space formed in shell 10 is oxygenation chamber.The cross section of oxygenation chamber is regular hexagon, and group is arranged inside
Cross section is the gas exchange units 20 of regular hexagon.Blood channel includes the Zhong blood channel 11 and position that oxygenation chamber side is arranged in
It is logical in the bleeding channel 12 of the oxygenation chamber other side, and the interface channel 13 in connection Zhong blood channel 11 and bleeding channel 12, oxygen
Road, which is located between Zhong blood channel 11 and bleeding channel 12, to be arranged, and the Zhong port 131 is located at the bottom of the oxygenation chamber；Outlet
Mouth 132 is two, and is located at the two sides of the oxygenation chamber.
In actual use, blood enters from 111 Zhong of Zhong blood mouth into Zhong blood channel 11, and by interface channel 13 and goes out
Blood channel 12 is finally flowed out by blood outlet 121, and above-mentioned blood Zhong goes out in flow process, and the carbon dioxide in blood penetrates gas
20 Zhong of body crosspoint enters into oxygen channel, and is discharged from the gas outlet of oxygen channel 132.Originally from the Zhong in oxygen channel
The oxygen that Zhong enters at port 131 also penetrates 20 Zhong of gas exchange units and enters into oxygen, to reduce carbon dioxide in blood
Concentration, and combine oxygen with blood, so that completing oxygen closes process.
Mono- step of Zhong, for the ease of production and processing, gas exchange units 20 preferably use the design of modular form, in two groups of gas
The top of body crosspoint 20 is provided with encapsulating housing 30, and it is whole that two groups of gas exchange units 20 are connected into one by encapsulating housing 30
Body.So in process, staff can directly pacify the assembly that gas exchange units 20 and encapsulating housing 30 are constituted
It is attached in the oxygenation chamber in shell 10, assembly working can be completed, to help to improve production efficiency.
Prevent these air from flowing back into from blood outlet 121 to eliminate mixed air in blood channel with reference to Fig. 1
In human body, the extracorporeal membrane oxygenation device of the present embodiment further includes the bubble eliminating structure for eliminating bubble in the blood channel,
Bubble eliminating structure includes：Extend at from the resin of 15 upper end of shell into oxygenation chamber, and the bubble for being connected to interface channel 13 disappears
Except channel 16.During blood travels up to interface channel from Zhong blood channel, interior mixed bubble will float, and
After Zhong enters interface channel 13, it is close to the roof flowing of interface channel 13, when the bubble after bubble eliminates channel 16, in blood
It will rupture, and channel 16 is eliminated by bubble and is escaped.
Obviously, the above embodiments are merely examples for clarifying the description, and does not limit the embodiments.It is right
For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of variation or
It changes.There is no necessity and possibility to exhaust all the enbodiments.And it is extended from this it is obvious variation or
It changes still within the protection scope of the invention.
Claims (6)
1. a kind of extracorporeal membrane oxygenation device, which is characterized in that including：
Shell (10), inside form oxygenation chamber, have blood channel in the oxygenation chamber and positioned at the blood channel both ends
Blood inlet (111), blood outlet (121)；In the oxygenation chamber also with oxygen channel and positioned at the oxygen channel both ends into
Port (131), gas outlet (132)；
Two groups of gas exchange units (20) are woven into predetermined shape, two groups of gas exchange units (20) by polymer fiber tubing
It is oppositely arranged and is arranged at intervals in the oxygenation chamber, formed and the air inlet between gas exchange units described in two groups
(131) the opposite two sides of the inlet channel being connected to, gas exchange units described in two groups and the oxygenation chamber are respectively formed two
Outlet passageway, the gas outlet (132) are two and are located at the two sides of the oxygenation chamber, two outlet passageways and two
The corresponding connection of a gas outlet (132), gas exchange units described in every group have first passage and lead to respectively with the air inlet
The second channel that road is connected to the outlet passageway also has the connection of two first passages of connection logical in the oxygenation chamber
Road (13), a first passage are connected to the blood inlet (111), another described first passage and the blood outlet
(121) it is connected to, the blood inlet (111), a first passage, the interface channel (13), another is described first logical
Road and the blood outlet (121) form the blood channel, the air inlet (131), the inlet channel, one described second
Channel and the outlet passageway form an oxygen channel, the air inlet (131), the inlet channel, another
A second channel and another described outlet passageway form another oxygen channel, so that in the oxygen channel
Oxygen can enter in the blood channel through the gas exchange units (20).
2. extracorporeal membrane oxygenation device according to claim 1, it is characterised in that：
The oxygenation chamber is regular hexagon；
Several equilateral triangle structure compositions that the gas exchange units (20) are woven by the polymer fiber tubing are just
Hexagonal structure.
3. extracorporeal membrane oxygenation device according to claim 1 or 2, it is characterised in that：
Further include connect every group at top described in gas exchange units (20) encapsulating housing (30), the encapsulating housing (30) will
Gas exchange units described in several groups (20) connection is integral.
4. extracorporeal membrane oxygenation device according to claim 1, it is characterised in that：
The air inlet (131) is located at the bottom of the oxygenation chamber.
5. extracorporeal membrane oxygenation device according to claim 1, it is characterised in that：
The shell (10) further includes the shell (15) of inner casing (14) and package inner casing (14) setting；
The both ends of the inner casing (14) and the shell (15) use resin seal.
6. extracorporeal membrane oxygenation device according to claim 5, it is characterised in that：
It further include the bubble eliminating structure for eliminating bubble in the blood channel, the bubble eliminating structure includes：By institute
It states and extends at the resin of shell (15) upper end into the oxygenation chamber, and the bubble for being connected to the interface channel (13) eliminates channel
(16)。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511016962.7A CN105396187B (en) | 2015-12-29 | 2015-12-29 | A kind of extracorporeal membrane oxygenation device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511016962.7A CN105396187B (en) | 2015-12-29 | 2015-12-29 | A kind of extracorporeal membrane oxygenation device |
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| Publication Number | Publication Date |
|---|---|
| CN105396187A CN105396187A (en) | 2016-03-16 |
| CN105396187B true CN105396187B (en) | 2018-11-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201511016962.7A Active CN105396187B (en) | 2015-12-29 | 2015-12-29 | A kind of extracorporeal membrane oxygenation device |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106421949B (en) * | 2016-08-29 | 2018-10-02 | 安徽通灵仿生科技有限公司 | A kind of oxygen closes drainage tube, oxygenation device and oxygen and closes method |
| CN113082339B (en) * | 2021-04-15 | 2022-09-02 | 上海超高环保科技股份有限公司 | Method for manufacturing ultra-high molecular artificial lung |
| CN117122814B (en) * | 2023-10-25 | 2024-02-02 | 北京航天长峰股份有限公司 | Pump head oxygenator assembly and extracorporeal membrane pulmonary oxygenation system |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4639353A (en) * | 1984-04-24 | 1987-01-27 | Mitsubishi Rayon Co., Ltd. | Blood oxygenator using a hollow-fiber membrane |
| CN2772515Y (en) * | 2004-04-23 | 2006-04-19 | 广东省医疗器械研究所 | Hollow fibrous coat oxygenator |
| CN205287056U (en) * | 2015-12-29 | 2016-06-08 | 中国科学院苏州生物医学工程技术研究所 | External membrane oxygenator |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2159220Y (en) * | 1993-05-15 | 1994-03-23 | 戴刚 | Membrance oxygenator with blood reservoir for internal suction |
| JPH10314300A (en) * | 1997-05-15 | 1998-12-02 | Terumo Corp | Hollow fiber membrane type artificial lung |
| CN2647323Y (en) * | 2003-08-20 | 2004-10-13 | 戴刚 | Non-pump driving external oxygenation supporting treatment hollow fiber membrane oxygenator |
| JP4366268B2 (en) * | 2004-07-23 | 2009-11-18 | テルモ株式会社 | Artificial lung |
| ITMI20060490A1 (en) * | 2006-03-17 | 2007-09-18 | Eurosets Srl | INTEGRATED DEVICE FOR BLOOD RE-HEALING AND OXYGENATION IN EXTRACORPOREAL CIRCUIT |
| CN201750925U (en) * | 2010-07-26 | 2011-02-23 | 天津市塑料研究所 | Membrane oxygenator |
| WO2012133372A1 (en) * | 2011-03-31 | 2012-10-04 | テルモ株式会社 | Artificial lung |
| CN202459508U (en) * | 2012-02-07 | 2012-10-03 | 中南大学湘雅二医院 | Portable pumpless extracorporeal membrane oxygenator |
-
2015
- 2015-12-29 CN CN201511016962.7A patent/CN105396187B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4639353A (en) * | 1984-04-24 | 1987-01-27 | Mitsubishi Rayon Co., Ltd. | Blood oxygenator using a hollow-fiber membrane |
| CN2772515Y (en) * | 2004-04-23 | 2006-04-19 | 广东省医疗器械研究所 | Hollow fibrous coat oxygenator |
| CN205287056U (en) * | 2015-12-29 | 2016-06-08 | 中国科学院苏州生物医学工程技术研究所 | External membrane oxygenator |
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| CN105396187A (en) | 2016-03-16 |
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