JPH10314300A - Hollow fiber membrane type artificial lung - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an outside blood recirculation type artificial lung which reduces the rate of formation of channelling of blood, has a sufficient efficiency for gas exchange, and decreases pressure losses. SOLUTION: A hollow fiber membrane type artificial lung 1 has a tubular hollow-fiber-membrane bundle 2 forming a blood circulating part 7c therein, a housing 3 enclosing the hollow fiber membrane bundle 2, partitions 5, 6 where both ends of the hollow fiber membrane bundle 2 are secured to the housing, and a gas inlet 11 and outlet 12. Inside the artificial lung 1 has a blood chamber 7 formed between the outer peripheral surface of the tubular hollow fiber membrane bundle 2 and the inner surface of a tubular housing main body 33. The blood chamber 7 is partitioned into first and second blood chambers 7a, 7b, the two blood chambers 7a, 7b being partitioned from each other in such a way that blood does not circulate from one blood chamber to the other without making contact with the hollow fiber membrane. The housing main body 33 has in its side face a blood inlet 8 communicated to the first blood chamber and a blood outlet 9 communicating with the second blood chamber 7b.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a hollow fiber membrane oxygenator for removing carbon dioxide in blood and adding oxygen to blood in extracorporeal blood circulation.

[0002]

2. Description of the Related Art As an artificial lung, a membrane-type artificial lung has become common. The membrane oxygenator mainly uses a hollow fiber membrane, and performs gas exchange of blood through the hollow fiber membrane. As an inflow method of blood into the artificial lung, an internal reflux method in which blood flows inside the hollow fiber membrane and a gas flows outside the hollow fiber membrane, and conversely, blood flows outside the hollow fiber membrane and the gas flows into the hollow fiber membrane There is an external reflux system that flows into the inside of the container. The former is known to have a large pressure loss when circulating blood. On the other hand, the latter is more advantageous than the former in pressure loss.

[0003]

In recent years, centrifugal pumps and pulsatile flow pumps have become widespread. In order to enable extracorporeal circulation with these pumps, it is desirable that the pressure loss of the oxygenator be small. However, in the external reflux type artificial lung, a blood flow path can be freely taken, so that blood drift is likely to occur. Further, when the filling rate of the hollow fiber membrane is increased to improve the gas exchange efficiency and the blood drift, the pressure loss increases. At present, there is an artificial lung in which one or a plurality of hollow fibers are wound directly on a support core or a sheet in which hollow fibers are arranged at regular intervals is wound. In an oxygenator having a hollow fiber membrane bundle of this type, blood flows from the inside of the hollow fiber membrane bundle, passes through the hollow fiber membrane bundle, flows out of the hollow fiber membrane bundle, and then flows out of the oxygenator. Type, and conversely,
There is a type in which blood flows in from the outside of the hollow fiber membrane bundle, passes through the hollow fiber membrane bundle, flows inside the hollow fiber membrane bundle, and then flows out of the oxygenator. However, in any of these methods, a blood drift, specifically, a partial blood stagnation site or a site with a slow flow tends to be formed inside the oxygenator. Therefore,
An object of the present invention is to reduce the formation of uneven flow of blood in an extracorporeal blood return oxygenator, and to have a sufficient gas exchange efficiency,
Another object of the present invention is to provide a hollow fiber membrane oxygenator having a low pressure loss.

[0004]

Means for achieving the above object are a plurality of hollow fiber membranes for gas exchange, each having a tubular hollow fiber membrane bundle forming a blood circulation part therein, and the tubular hollow fiber membrane. A housing for accommodating the bundle, two partition walls for fixing both ends of the tubular hollow fiber membrane bundle to the housing with both ends of the hollow fiber membrane open, and a gas flow communicating with the inside of the hollow fiber membrane A hollow fiber membrane oxygenator having an inlet and a gas outlet, wherein the housing has a cylindrical housing main body, and the inside of the oxygenator includes an outer peripheral surface of the cylindrical hollow fiber membrane bundle and the cylindrical shape. A blood chamber formed between inner surfaces of the housing main body, wherein the blood chamber is divided into a first blood chamber and a second blood chamber, and the first blood chamber and the second blood chamber are provided; Is that blood contacts the hollow fiber membrane from one blood chamber to the other And the cylindrical housing body is provided with a blood inlet and a first blood chamber that communicate with one of the first blood chamber and the second blood chamber on a side surface. Or a hollow fiber membrane type artificial lung having a blood outlet communicating with the other of the second blood chamber.

[0005] The artificial lung is, for example,
The blood chamber and the second blood chamber are provided with a partition wall that communicates through a blood circulation part formed substantially inside the tubular hollow fiber membrane bundle. In addition, the hollow fiber membrane-type artificial lung includes, for example, two partition walls extending from the one partition to the other partition, and the two partition walls vertically extend the cylindrical blood chamber in the axial direction. It is divided into two. Further, the partition wall is, for example, an annular partition wall formed in the vicinity of an axial center of the cylindrical housing main body, and the annular partition wall causes the blood chamber to be a first partition side. Blood chamber and the other partition wall side
And a blood chamber.

Further, the housing has, for example, a partition member or an inner wall portion which is almost in close contact with the hollow fiber membrane bundle, and the blood chamber is formed by the partition member or the inner wall portion. And a second blood chamber. Further, for example, two partition members or inner wall portions that are almost liquid-tightly attached to the hollow fiber membrane bundle are formed so as to extend from the one partition wall to the other partition wall. The cylindrical blood chamber is divided vertically into two parts by the portion. Further, the partition member or the inner wall portion that is almost liquid-tightly adhered to the hollow fiber membrane bundle is formed in an annular shape, for example, near the axial center of the cylindrical housing body, and The blood chamber is partitioned by an inner wall portion into a first blood chamber on one partition wall side and a second blood chamber on the other partition wall side. The area in which the partition wall or the partition member or the inner wall portion which is almost liquid-tightly adhered to the hollow fiber membrane bundle covers the outer surface of the hollow fiber membrane bundle is 5 times the area of the outer surface of the hollow fiber membrane bundle. It is preferably about 20%.

The housing has an inner cylindrical member having an opening for blood circulation on a side surface, and the hollow fiber membrane bundle is wound around an outer surface of the inner cylindrical member. Is preferably fixed to the tubular housing body by the partition. Further, the hollow fiber membrane bundle is formed by winding the hollow fiber membrane around the inner cylindrical member such that one or a plurality of the hollow fiber membranes are simultaneously and all the hollow fiber membranes are at substantially constant intervals. Preferably, it is formed.

[0008]

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is an exploded perspective view of a hollow fiber membrane oxygenator according to the present invention. FIG. 1 is a sectional view showing one embodiment of the hollow fiber membrane-type oxygenator of the present invention, and FIG.
FIG. 3 is a sectional view taken along line AA of FIG. 1, and FIG.
It is a B sectional view. The hollow fiber membrane-type artificial lung 1 of the present invention is composed of a large number of hollow fiber membranes for gas exchange, and has a blood circulation part 7 therein.
c, a housing 3 for accommodating the tubular hollow fiber membrane bundle 2, and a housing in which both ends of the hollow fiber membrane are open with both ends open. And a gas inlet 11 and a gas outlet 12 communicating with the inside of the hollow fiber membrane. The housing 3 has a cylindrical housing main body 33, and the inside of the artificial lung 1 includes a blood chamber 7 formed between the outer peripheral surface of the cylindrical hollow fiber membrane bundle 2 and the inner surface of the cylindrical housing main body 33. The blood chamber 7 is partitioned into a first blood chamber 7a and a second blood chamber 7b, and the first blood chamber 7a and the second blood chamber 7b are connected to one blood chamber from the other blood chamber. It is partitioned so that blood does not flow without contacting the hollow fiber membrane. The cylindrical housing body 33 is connected to the blood inlet port 8 communicating with one of the first blood chamber 7a or the second blood chamber 7b on the side surface and the other of the first blood chamber 7a or the second blood chamber 7b. It has a blood outlet 9 for communication.

In the hollow fiber membrane type artificial lung 1 of the embodiment shown in FIGS. 1 and 2, the housing 3 has a cylindrical housing main body 3.
3, an inner cylindrical member 31 housed in the cylindrical housing body 33, having a number of blood circulation openings 32 on the side surface, and forming a blood circulation portion 7c therein; And an inner cylinder 35 housed therein.

In the hollow fiber membrane-type artificial lung 1 of this embodiment, the blood chamber 7 is divided into a first blood chamber 7a and a second blood chamber 7b. Second
Partition walls 4a, 4b for communicating the blood chamber 7b through a blood circulation portion 7c formed inside the tubular hollow fiber membrane bundle 2.
b. The tubular hollow fiber membrane bundle 2 is wound around the outer surface of the inner tubular member 31. That is, the inner tubular member 31 is the core of the tubular hollow fiber membrane bundle 2.

The inner cylindrical body 35, the inner cylindrical member 31 around which the hollow fiber membrane bundle 2 is wound around the outer surface, and the cylindrical housing main body 33 are arranged substantially concentrically. One end (upper end) of the inner tubular member 31 around which the hollow fiber membrane bundle 2 is wound around the outer surface, one end (upper end) of the tubular housing main body 33, and one end (upper end) of the inner tubular body 35 are the first.
The concentric positional relationship is maintained by the partition walls 5, and the space formed between the inside of the inner tubular member and between the tubular housing body 33 and the outer surface of the hollow fiber membrane does not communicate with the outside. Similarly, at one end (end) of the inner cylinder 35, the inner space and the outer space are in a liquid-tight state so as not to communicate with the outside.

The other end (lower end) of the inner cylindrical member 31 and the other end (lower end) of the inner cylindrical member 31 around which the hollow fiber membrane bundle 2 is wound on the outer surface are the second partition walls. 6, the concentric positional relationship is maintained, and the space formed between the inner cylindrical body 35 and the inner cylindrical member 31 and the space formed between the cylindrical housing body 33 and the outer surface of the hollow fiber membrane are formed. So that the space does not communicate with the outside
Similarly, the other end (lower end) of the inner cylinder 35 is in a liquid-tight state so that the inner space and the outer space do not communicate with the outside. The partition walls 5 and 6 are formed of a potting agent which is an elastic material having an adhesive property such as polyurethane or silicone rubber.

In the artificial lung 1 of this embodiment, the blood chamber 7, which is a cylindrical space formed between the outer peripheral surface of the cylindrical hollow fiber membrane bundle 2 and the inner surface of the cylindrical housing body 33, 2
The first blood chamber 7a and the second blood chamber 7a are separated by the two partition walls 4a and 4b.
In the blood chamber 7b. The side surface of the cylindrical housing body 33 has a blood inlet 8 communicating with the first blood chamber 7a and a blood outlet 9 communicating with the second blood chamber 7b. The partition walls 4a and 4b are made of an adhesive and elastic material such as polyurethane or silicone rubber, and are formed by a so-called potting agent. The potting agent forming the partition walls 4a and 4b is
It penetrates into the hollow fiber membrane bundle at the portion in contact with the partition walls 4a and 4b. For this reason, the hollow fiber membrane bundle is also divided into two by the partition walls 4a and 4b. As a result, the first blood chamber 7a and the second blood chamber 7b communicate with each other only via the blood circulation part 7c formed inside the tubular hollow fiber membrane bundle 2. In addition, in the artificial lung 1 of this embodiment, the inner cylindrical body 35 is provided so that the inside of the tubular hollow fiber membrane bundle 2 (the inner tubular member 31
The blood circulating portion 7c formed between the inner cylindrical body 35 and the inner cylindrical body 35) is also substantially a cylindrical space.

In the oxygenator of this embodiment, the blood chamber 7, which is a cylindrical space formed between the outer peripheral surface of the cylindrical hollow fiber membrane bundle 2 and the inner surface of the cylindrical housing main body 33, is a housing main body. It is divided into two as if it was divided vertically in the axial direction of
The first blood chamber 7a forms a blood inflow side blood chamber, and the second blood chamber 7b forms a blood outflow side blood chamber. The blood inlet 8 is provided at an upper portion of the side surface of the housing main body 33 so as to communicate with the upper portion of the first blood chamber 7a (blood inflow side blood chamber), and the blood outlet 9 is provided at the second blood chamber 7a. The lower part of the side surface of the housing main body 33 is provided so as to communicate with the lower part of the blood chamber 7b (blood chamber on the blood outflow side).

As shown in FIGS. 2 and 3, the two partition walls 4a and 4b are formed at positions facing the center of the tubular hollow fiber membrane bundle 2, and further, the shaft of the hollow fiber membrane bundle is formed. Extending parallel to the direction. The two partition walls 4a and 4b are also parallel. For this reason, the blood chamber 7, which is a cylindrical space formed between the outer peripheral surface of the cylindrical hollow fiber membrane bundle 2 and the inner surface of the cylindrical housing main body 33, has two partition walls 4a,
4b, it is divided into two in the longitudinal direction in the axial direction, and is divided into two parts so as to be substantially equally divided (to be divided in half). In addition, the division form is not limited to such an equal division. For example, as shown in FIG. 7, the first blood chamber 7a on the blood inflow side is narrow, and the second blood chamber 7b The side may be wider or vice versa. Assuming that the area of the outer peripheral surface of the cylindrical hollow fiber membrane bundle 2 is 100, the area of the outer peripheral surface of the cylindrical hollow fiber membrane bundle 2 on the first blood chamber 7a side and the cylinder on the second blood chamber 7b side The ratio of the area of the outer peripheral surface of the hollow fiber membrane bundle 2 is 30: 7
About 0 to 70:30 is suitable.

It is preferable that the width of the partition walls 4a and 4b is narrow. However, if the width is too narrow, it causes a short circuit of blood. Therefore, the width is preferably 20 to 90 mm, preferably about 20 to 50 mm. By using simple expressions, the partition walls 4a, 4b
However, the area covering the outer surface of the tubular hollow fiber membrane bundle 2 is preferably about 5 to 20% of the area of the outer surface of the tubular hollow fiber membrane bundle 2. The two partition walls 4a and 4b of this form are formed so as to be parallel and substantially opposite to each other.
4b is preferably parallel to the axis of the housing, but may be formed helically.

In this artificial lung, as shown in FIGS. 2 and 4, an opening extending in the axial direction is provided on the side surface of the inner cylindrical member 31 corresponding to the portion where the two partition walls 4a and 4b are formed. A non-formed portion 31a is provided. For this reason, the potting agent forming the partition walls 4 a and 4 b does not flow into the inside of the inner tubular member 31, in other words, into the blood circulation portion 7 c formed inside the tubular hollow fiber membrane bundle 2. Further, one end of the cylindrical housing body 33 is provided with a gas inlet 1.
A gas inflow member 41 having a gas outlet 1 is fixed to the other end of the cylindrical housing body 33.
2 is fixed.

In this artificial lung, the blood flowing from the blood inlet 8 flows into the first blood chamber 7a, and the portion of the cylindrical hollow fiber membrane bundle 2 exposed in the first blood chamber 7a. From the outer surface of the cylindrical hollow fiber membrane bundle 2, passes through the cylindrical hollow fiber membrane bundle 2, flows through the opening of the inner cylindrical member 31, and flows into the blood circulation part 7 c. At this time, blood is gas-exchanged to some extent. Then, from the blood inflow portion, through the opening 32 of the inner cylindrical member 31, the blood enters the membrane bundle from the inner surface side of the hollow fiber membrane bundle on the second blood chamber 7b side, and the cylindrical hollow fiber Membrane bundle 2
And flows into the second blood chamber 7b. At this time, the blood is gas-exchanged again. And the second blood chamber 7b
The blood flowing into the blood flows out from the blood outlet 9.

As the cylindrical housing body 33, a cylindrical body, a polygonal cylinder, an elliptical cross section, or the like can be used. Preferably it is a cylindrical body. Also, the cylindrical housing body 33
Is preferably about 30 to 150 mm, and the length (effective length) is preferably about 30 to 750 mm.

As the inner cylindrical member 31, a cylindrical body, a polygonal cylinder, or a member having an elliptical cross section can be used. Preferably it is a cylindrical body. The inner diameter of the inner cylindrical member 31 is preferably about 20 to 100 mm, and the length (effective length) is preferably about 15 to 765 mm. And
The inner cylindrical member 31 has a number of blood circulation openings 32 on the side surface.
It has. The opening 32 preferably has a large total area as long as the required strength of the tubular member is maintained. Further, the shape of the opening 32 may be a circle, a polygon, an ellipse, or the like.
An oval shape as shown in FIG. 4 is preferable. The inner tubular member 31 has two non-opening portions 31a extending in the axial direction on side surfaces of the inner tubular member 31 corresponding to portions where the two partition walls 4a and 4b are formed. I have. As the inner cylinder 35, a cylinder, a polygonal cylinder, an elliptical cross section, or the like can be used. Preferably it is a cylindrical body. The inner diameter of the inner cylinder 35 is preferably about 10 to 40 mm. Then, on the outer surface of the inner tubular member 31,
A tubular hollow fiber membrane bundle 2 is wound. The outer diameter of the hollow fiber membrane bundle 2 is preferably 30 to 144 mm, and the filling rate is preferably 45 to 75%.

As the hollow fiber membrane for gas exchange, a porous membrane is used. As the porous hollow fiber membrane, an inner diameter of 100 to 1
000 μm, wall thickness is 5-200 μm, preferably 10-200 μm
100 μm, porosity is 20 to 80%, preferably 30 to 80%
Those having a pore size of 60% and a pore size of 0.01 to 5 μm, preferably 0.01 to 1 μm can be preferably used. Also,
Materials used for the porous membrane include polypropylene,
Polyethylene, polysulfone, polyacrylonitrile,
A hydrophobic polymer material such as polytetrafluoroethylene and cellulose acetate is used. Preferably, it is a polyolefin-based resin, particularly preferably polypropylene, and more preferably a resin having fine pores formed in a wall by a stretching method or a solid-liquid phase separation method. The hollow fiber membrane bundle 2
Is preferably 5 mm to 25 mm.

The tubular hollow fiber membrane bundle 2 is formed, for example, by winding a hollow fiber membrane around an inner tubular member 31, specifically, forming a hollow fiber bobbin with the inner tubular member 31 as a core. The hollow fiber membrane bobbin thus formed can be formed by fixing both ends of the hollow fiber membrane bobbin together with the inner cylindrical member 31 as the core after fixing the partition wall. By this cutting, the hollow fiber membrane is opened on the outer surface of the partition. In particular, it is preferable that one or a plurality of hollow fiber membranes are simultaneously wound around the inner tubular member 31 so that substantially parallel and adjacent hollow fiber membranes have a substantially constant interval. Thereby, the drift of blood can be further suppressed. Further, the distance between the hollow fiber membrane and the adjacent hollow fiber membrane is
30 μm to 200 μm is preferred, and particularly preferably 5 μm to 200 μm.
It is 0 μm to 180 μm.

As the material for forming the cylindrical housing body 33, the inner cylindrical member 31, and the inner cylindrical body 35, polyolefin (for example, polyethylene and polypropylene), ester-based resin (for example, polyethylene terephthalate),
Styrene resin (for example, polystyrene, MS resin, M
BS resin) and polycarbonate.

Next, the hollow fiber membrane oxygenator 50 of the embodiment shown in FIGS. 5 and 6 will be described. The basic configuration of the hollow fiber membrane oxygenator 50 is the same as that of the oxygenator 1 of the embodiment shown in FIG. 1 and described above, and the difference is the form of formation of the partition wall and the first blood chamber 7a resulting therefrom. And the second blood chamber 7b
The only difference is the form of In the artificial lung 50 of this embodiment, the partition wall 55 is an annular body formed near the center in the axial direction of the tubular hollow fiber membrane bundle 2. In the oxygenator 50, the blood compartment 7, which is a cylindrical space formed between the outer peripheral surface of the cylindrical hollow fiber membrane bundle 2 and the inner surface of the cylindrical housing main body 33, is formed by the annular partition wall 55. First blood chamber 7 to be side
a and a second blood chamber 7b on the other partition 6 side. That is, the blood chamber 7 is vertically divided into two with respect to the axial direction of the housing. Annular partition wall 5
5 is preferably perpendicular to the central axis of the cylindrical housing body 33 as shown in FIG. 5, but may be formed obliquely at a predetermined angle with respect to the central axis.

In this embodiment, the upper first
The blood chamber 7a forms a blood inflow side blood chamber, and the second blood chamber 7b forms a blood outflow side blood chamber. The blood inlet 8 is connected to the first blood chamber 7a (blood chamber on the blood inflow side).
The blood outlet 9 is provided at the upper part of the side surface of the housing body so as to communicate with the upper part of the second blood chamber 7b.
The lower part of the side surface of the housing main body is provided so as to communicate with the lower part of the (blood outlet side blood chamber).

In this embodiment, the annular partition wall 55
, The blood chamber 7 is divided into two approximately equal parts, but the division form is not limited to such an equal part, and for example, the first blood on the blood inflow side Room 7
a may be narrow and the second blood chamber 7b side may be wide, or vice versa. Assuming that the area of the outer peripheral surface of the cylindrical hollow fiber membrane bundle 2 is 100, the area of the outer peripheral surface of the cylindrical hollow fiber membrane bundle 2 on the side of the first blood chamber 7a and the second blood chamber 7b
The ratio of the area of the outer peripheral surface of the cylindrical hollow fiber membrane bundle 2 on the side is 3
About 0:70 to 70:30 is suitable.

The width of the annular partition wall 55 is preferably narrow, but if it is too narrow, it causes a short circuit of blood. Therefore, the width is preferably 20 to 90 mm, preferably about 20 to 50 mm. Using the expression, the annular partition wall 55
However, the area covering the outer surface of the tubular hollow fiber membrane bundle 2 is preferably about 5 to 20% of the area of the outer surface of the tubular hollow fiber membrane bundle 2.

Also in this artificial lung 50, as shown in FIGS. 5 and 6, the side surface of the inner cylindrical member 51 corresponding to the portion where the partition wall 55 is formed has a predetermined width and is formed in an annular shape. The formed non-opening portion 51a is provided. For this reason, the potting agent forming the partition wall 55 does not flow into the inside of the inner tubular member 51, in other words, into the blood circulation portion 7 c formed inside the tubular hollow fiber membrane bundle 2.

In this artificial lung 50, the blood flowing from the blood inlet 8 flows into the first blood chamber 7a, and the portion of the cylindrical hollow fiber membrane bundle exposed in the first blood chamber 7a. 2 enters the tubular hollow fiber membrane bundle 2 from the outer surface, passes through the tubular hollow fiber membrane bundle 2, passes through the opening 52 of the inner tubular member 51, and flows through the blood on the first blood chamber 7 a side. The blood that has flowed into the part 7c flows downward and flows into the blood inflow part on the second blood chamber 7b side. Then, the blood flowing into the blood inflow portion on the second blood chamber 7b side passes through the opening 52 of the inner cylindrical member 51 on the second blood chamber 7b side, and the hollow fiber membrane on the second blood chamber 7b side. It enters the membrane bundle from the inner side of the bundle 2, passes through the tubular hollow fiber membrane bundle 2, and flows into the second blood chamber 7b. The blood that has flowed into the second blood chamber 7b flows out of the blood outlet 9.

As the inner tubular member 51, a cylindrical body, a polygonal tubular body, a member having an elliptical cross section, or the like can be used. Preferably it is a cylindrical body. The inner diameter of the inner tubular member 51 is 20
About 100 mm is preferable, and the length (effective length) is 1
About 5 to 765 mm is preferable. The inner cylindrical member 51 has a large number of blood circulation openings 52 on the side surface. As long as the opening 52 maintains the required strength of the cylindrical member,
Preferably, the total area is large. Further, the shape of the opening 52 may be a circle, a polygon, an ellipse, or the like, but an oval shape is preferable. The inner tubular member 51 is provided with an annular non-opening portion 51a on the side surface of the inner tubular member 51 corresponding to the portion where the partition wall 55 is formed as described above. The tubular hollow fiber membrane bundle 2 is wound around the outer surface of the inner tubular member 51. As the hollow fiber membrane for gas exchange, those described above are preferable.

In the oxygenator of the above-described embodiment, the hollow fiber membrane bundle 2 is used to stabilize the shape of the cylindrical hollow fiber membrane bundle 2.
Although the inner tubular member 51 used as the core is used as it is when forming the, the inner tubular member 51 is not necessarily provided. That is, after the hollow fiber membrane bundle is formed, the inner tubular member 51 may be removed, and only the tubular hollow fiber membrane bundle 2 may be used.

Next, the hollow fiber membrane type artificial lung of the embodiment shown in FIGS. 8, 9 and 10 will be described. FIG. 8 is a cross-sectional view showing another embodiment of the hollow fiber membrane oxygenator 60 of the present invention, FIG. 9 is a cross-sectional view taken along line DD of FIG. 8, and FIG.
FIG. 9 is a sectional view taken along line EE of FIG. 8. Also in the hollow fiber membrane oxygenator 60 of this embodiment, similarly to the hollow fiber membrane oxygenator 1 shown and described in FIGS. 1 to 3, the housing 3 includes a cylindrical housing main body 33 and this cylindrical housing main body. 33, an inner cylindrical member 31 having a number of blood circulation openings 32 on the side surface and forming a blood circulation part 7c therein, and an inner cylindrical body 35 accommodated in the inner cylindrical member 31. Is provided.

In the hollow fiber membrane oxygenator 60 of this embodiment,
As shown in FIGS. 9 and 10, the housing has a partition member 64 that is almost liquid-tightly adhered to the outer surface of the tubular hollow fiber membrane bundle 2.
a, 64b, and the partition members 64a, 64b partition the blood chamber 7 into a first blood chamber 7a and a second blood chamber 7b.

The basic configuration of the oxygenator 60 of this embodiment is the same as that of the hollow fiber membrane oxygenator 1 shown and described in FIGS. 1 to 3 except for the partition wall 4a of the hollow fiber membrane oxygenator 1. , 4
The only difference is that the partition members 64a and 64b are provided instead of b. For this reason, common parts are denoted by the same reference numerals, and the description thereof refers to those described above. In the oxygenator 60 of this embodiment, the blood chamber 7, which is a cylindrical space formed between the outer peripheral surface of the cylindrical hollow fiber membrane bundle 2 and the inner surface of the cylindrical housing main body 33, has two partition members 64a, The first blood chamber 7a and the second blood chamber 7b are partitioned by 64b. A blood inlet 8 communicating with the first blood chamber 7a is provided on a side surface of the cylindrical housing body 33.
Has a blood outlet 9 communicating with the blood chamber 7b.

Two partition members 64a and 64b extending in the axial direction are fixed to the inner surface of the cylindrical housing body 33. The partition members 64a and 64b are made of, for example, synthetic rubber such as urethane rubber, silicone rubber, butadiene rubber, natural rubber such as latex rubber, soft vinyl chloride, elastomer such as olefin-based elastomer, amide-based elastomer, and styrene-based elastomer. Adhesive materials such as elastic materials, epoxy resins, and even
For example, it is formed of an adhesive elastic material such as adhesive urethane rubber and adhesive silicone rubber (RTV silicone rubber, LTV silicone rubber).

The partition members 64a, 64b are not limited to those formed by members separate from the cylindrical housing main body 33. The partition members 64a, 64b are formed on the cylindrical housing main body 33.
b may be integrally formed by two-color molding, or may be integrally formed by so-called insert molding in which a preformed elastic member is inserted into a mold to form the cylindrical housing body 33. Good. When forming the partition members 64a and 64b in a part of the housing using the two-color molding and the insert molding, it is preferable that the material for forming the housing body and the material for forming the partition members have adhesiveness.

When the two-color molding method is used, for example, the housing body is made of polyolefin (polyethylene,
Polypropylene elastomer (polyethylene elastomer, polypropylene elastomer) is used as the material for forming the partition member when formed of polypropylene), and the partition member is formed when the housing body is formed of an ester-based resin (for example, polyethylene terephthalate). , Polyester elastomer, the housing body is a styrene-based resin (for example, polystyrene, MS resin,
As a material for forming the partition member when formed of MBS resin, a styrene-based elastomer (for example, styrene-butadiene-styrene copolymer, styrene-isoprene-styrene copolymer, styrene-ethylenebutylene-
Styrene copolymers) can be used.

The partition members 64a and 64b have elasticity,
Further, as shown in FIG. 10, the distal end has a shape that can be in close contact with the outer surface of the tubular hollow fiber membrane bundle. For this reason,
The partition member is almost liquid-tightly adhered to the outer surface of the tubular hollow fiber membrane bundle 2. The blood chamber 7 is partitioned into a first blood chamber 7a and a second blood chamber 7b by the two partition members 64a and 64b, and the first blood chamber and the second blood chamber are connected to one blood chamber. The blood is partitioned from the chamber into the other blood chamber so that the blood does not flow without contacting the hollow fiber membrane. That is, the blood chamber 7 does not contact the hollow fiber membrane,
Are separated by the partition members 64a and 64b so that a blood flow flowing by short-circuiting from the blood chamber 7a to the second blood chamber 7b (or from the second blood chamber to the first blood chamber) is not formed. In this artificial lung 60, since the inside of the tubular hollow fiber membrane bundle 2 is not divided, the blood circulation part 7c
From the first blood chamber without flowing into the partition member 64.
There is a possibility that some blood may flow into the second blood chamber through the inside of the tubular hollow fiber membrane bundle 2 located inside the a and 64b. However, there is no particular problem because the blood volume is extremely small, and the blood contacts at least the hollow fiber membrane to perform gas exchange.

As shown in FIG. 9, both ends of the partition members 64a and 64b do not extend to the ends of the cylindrical housing body 33, and end slightly at positions inside the both ends of the housing body. Therefore, the potting agent forming the partition walls 5 and 6 can flow between the end of the cylindrical housing main body 33 and the end of the cylindrical hollow fiber membrane bundle. Therefore, the tubular hollow fiber membrane bundle 2 is securely fixed to the tubular housing main body 33. Further, when the tubular hollow fiber membrane bundle 2 (including the inner tubular member 31) is housed in the tubular housing body 33, the tubular housing body 33 is gripped by a jig, and the blood inflow port 8 is moved. Provided side and blood outlet 9
Between the side surfaces provided with the partition members 64a, 6
After the spaces 4b are separated from each other, the tubular hollow fiber membrane bundle 2 is inserted, and the pressing can be released to be stored.

It should be noted that also in the artificial lung 60 of this embodiment, the outer peripheral surface of the cylindrical hollow fiber membrane bundle 2 and the cylindrical housing body 3
Blood chamber 7 which is a cylindrical space formed between the inner surfaces of 3
Are divided into two sections as if they were vertically divided in the axial direction of the housing body, the first blood chamber 7a forms a blood inflow side blood chamber, and the second blood chamber 7b forms a blood outflow side blood chamber. Has formed. The blood inlet 8 is connected to the first blood chamber 7a.
The blood outlet 9 is provided at the upper part of the side surface of the housing body 33 so as to communicate with the upper part of the (blood inflow side blood chamber), and communicates with the lower part of the second blood chamber 7b (the blood outflow side blood chamber). It is provided at the lower part of the side surface of the housing main body 33 so that

As shown in FIGS. 9 and 10, the two partition members 64a and 64b are formed at positions facing the center of the tubular hollow fiber membrane bundle 2, and further, the shaft of the hollow fiber membrane bundle is formed. Extending parallel to the direction. Two partition members 64
a and 64b are also parallel. Therefore, the blood chamber 7, which is a cylindrical space formed between the outer peripheral surface of the cylindrical hollow fiber membrane bundle 2 and the inner surface of the cylindrical housing main body 33, is vertically extended in the axial direction by the two partition members 64a and 64b. To two,
It is divided into two parts so as to be almost equally divided (half).
Note that the division form is not limited to such an equal division. For example, similarly to the one shown in FIG. 7, the first blood chamber 7a on the blood inflow side is narrow and the second The blood chamber 7b may be widened, or vice versa.
Assuming that the area of the outer peripheral surface of the tubular hollow fiber membrane bundle 2 is 100,
The ratio of the area of the outer peripheral surface of the cylindrical hollow fiber membrane bundle 2 on the first blood chamber 7a side to the area of the outer peripheral surface of the cylindrical hollow fiber membrane bundle 2 on the second blood chamber 7b side is 30:70. About 70:30 is suitable.

The width of the partition members 64a and 64b in close contact with the cylindrical hollow fiber membrane bundle 2 (the width of the contact portion of the partition member with the cylindrical hollow fiber membrane bundle) is preferably small, but if it is too narrow. ,
20 to 90 mm, preferably about 20 to 50 mm is suitable because it causes a short circuit of blood. In other words, the partition members 64a and 64b are formed by the tubular hollow fiber membrane bundle 2
Is preferably about 5 to 20% of the area of the outer surface of the tubular hollow fiber membrane bundle 2. Further, the two partition members 64a and 64b of this form are formed so as to be parallel and substantially facing each other, and the partition members 64a and 64b are formed.
b is preferably parallel to the axis of the housing, but may be helically formed.

Also in this artificial lung 60, as shown in FIGS. 9 and 10, two partition members 64a, 64a are provided.
An opening non-forming portion 31a extending in the axial direction is provided on the side surface of the inner cylindrical member 31 corresponding to the portion where b is located. For this reason, the tubular hollow fiber membrane bundle 2 is formed by the non-opening portion 31a of the inner tubular member 31 and the partition members 64a and 64b.
Since the compression can be performed, the close contact of the partition member with the tubular hollow fiber membrane bundle 2 becomes more reliable.

Also in the artificial lung 60, most of the blood that has flowed through the blood inlet 8 flows into the first blood chamber 7a, and the part of the blood that is exposed in the first blood chamber 7a The tubular hollow fiber membrane bundle 2 penetrates into the tubular hollow fiber membrane bundle 2 from the outer surface thereof, passes through the tubular hollow fiber membrane bundle 2, and has an inner tubular member 3.
Through one opening, it flows into the blood circulation part 7c. At this time, blood is gas-exchanged to some extent. Then, from the blood inflow portion, through the opening 32 of the inner cylindrical member 31, the blood enters the membrane bundle from the inner surface side of the hollow fiber membrane bundle on the second blood chamber 7b side, and the cylindrical hollow fiber It passes through the membrane bundle 2 and flows into the second blood chamber 7b. At this time, the blood is gas-exchanged again. The blood that has flowed into the second blood chamber 7b flows out of the blood outlet 9.

Next, the hollow fiber membrane type artificial lung of the embodiment shown in FIGS. 11, 12 and 13 will be described. FIG.
Is a cross-sectional view showing another embodiment of the hollow fiber membrane oxygenator of the present invention, FIG. 12 is a cross-sectional view taken along line FF of FIG.
FIG. 13 is a sectional view taken along line GG of FIG. In the hollow fiber membrane oxygenator 70 of this embodiment as well, similarly to the hollow fiber membrane oxygenator 1 shown in FIGS. 1 to 3, the housing 3 includes a cylindrical housing main body 73 and this cylindrical housing main body. 73 and a large number of blood circulation openings 3 on the side.
2 and an inner tubular member 31 forming a blood circulation portion 7c therein, and an inner tubular body 35 housed in the inner tubular member 31.

The hollow fiber membrane oxygenator 7 of this embodiment
0, the housing has inner wall portions 73a and 73b that are almost liquid-tightly adhered to the outer surface of the tubular hollow fiber membrane bundle 2, and the blood chamber 7 is formed by the inner wall portions 73a and 73b. 7a and a second blood chamber 7b.

The basic configuration of the oxygenator 70 of this embodiment is the same as that of the hollow fiber membrane oxygenator 1 shown and described in FIGS. 1 to 3, except for the partition wall 4 a of the hollow fiber membrane oxygenator 1. , 4
Instead of b, the only difference is that inner wall portions 73a and 73b are provided on the outer surface of the tubular hollow fiber membrane bundle 2 in a substantially liquid-tight manner. For this reason, common parts are denoted by the same reference numerals, and the description thereof refers to those described above. In the artificial lung 70 of this embodiment, the blood chamber 7 formed between the outer peripheral surface of the cylindrical hollow fiber membrane bundle 2 and the inner surface of the cylindrical housing body 73 is located on the outer surface of the two cylindrical hollow fiber membrane bundles 2. The first blood chamber 7a and the second blood chamber 7b are partitioned by the inner wall portions 73a and 73b which are almost in close contact with each other. The side surface of the cylindrical housing body 73 has a blood inlet 8 communicating with the first blood chamber 7a and a blood outlet 9 communicating with the second blood chamber 7b.

A gas inflow member 41 having a gas inlet 11 is fixed to one end of the cylindrical housing body 73, and a gas outlet 12 is similarly provided at the other end of the cylindrical housing body 73. The gas outflow member 42 is fixed. As the cylindrical housing body 73, one having a substantially elliptical cross section is used. For this reason, the inner wall surface of the closest part of the cylindrical housing body 73 is
Inner wall portions 73a and 73b that are almost liquid-tightly adhered to the outer surface of the two tubular hollow fiber membrane bundles 2 are formed. The cylindrical housing main body 73 preferably has such a cross section that is substantially elliptical, but it is sufficient that the main body has a portion that is closer to the other portion than the other portion, and has a polygonal cross section. You may. Further, the inner wall portions 73a and 73b that are almost liquid-tightly adhered to the outer surface of the tubular hollow fiber membrane bundle 2 are provided in order to improve the close contact with the outer surface of the tubular hollow fiber membrane bundle 2. The bundle 2 may be curved corresponding to the outer surface shape. The tubular housing body 73 is preferably the above-described substantially elliptical tubular body, and the shortest distance in the cross section is about 29 to 144 mm, the longest distance is about 31 to 76 mm, and the length (effective length) is About 30 to 750 mm is preferable.

The housing body 73 is slightly resilient or bendable, and the inner wall portions 73a and 73b have a shape that can be in close contact with at least the outer surface of the tubular hollow fiber membrane bundle as shown in FIG. ing. As a material for forming the cylindrical housing body 73, the inner cylindrical member 31, and the inner cylindrical body 35, polyolefin (for example, polyethylene or polypropylene), ester-based resin (for example, polyethylene terephthalate), styrene-based resin (for example, polystyrene, MS) Resin, MBS resin) and polycarbonate.

The blood chamber 7 is partitioned into a first blood chamber 7a and a second blood chamber 7b by the two inner wall portions 73a and 73b, and the first blood chamber and the second blood chamber 7b are separated from each other.
Is partitioned so that blood does not flow from one blood chamber to the other blood chamber without contacting the hollow fiber membrane. That is, the blood chamber 7 flows from the first blood chamber 7a to the second blood chamber 7b (or from the second blood chamber to the first blood chamber) without contacting the hollow fiber membrane. Are separated by the inner wall portions 73a and 73b so as not to be formed. In the artificial lung 70, since the inside of the tubular hollow fiber membrane bundle 2 is not partitioned, the inside of the inner wall portions 73a and 73b is not flown into the blood circulation part 7c but from the first blood chamber. Positioned tubular hollow fiber membrane bundle 2
, There is a possibility that blood slightly flows into the second blood chamber. However, there is no particular problem because the blood volume is extremely small, and the blood contacts at least the hollow fiber membrane to perform gas exchange.

Further, when the tubular hollow fiber membrane bundle 2 (including the inner tubular member 31) is housed in the tubular housing body 73, the tubular housing body 73 is gripped by a jig,
It presses between the side surface where the blood inlet 8 is provided and the side surface where the blood outlet 9 is provided, and the inner wall portions 73a and 73b are pressed.
After the separation, the tubular hollow fiber membrane bundle 2 is inserted, and the above-mentioned pressing is released, so that the bundle can be stored.

In the artificial lung 70 of this embodiment, the outer peripheral surface of the tubular hollow fiber membrane bundle 2 and the tubular housing body 7 are also provided.
The blood chamber 7 formed between the inner surfaces of the first and second blood chambers 3 is divided into two as vertically divided in the axial direction of the housing main body, the first blood chamber 7a forms a blood inflow side blood chamber, and the second blood chamber 7a forms a second blood chamber. Blood chamber 7
b forms a blood outflow side blood chamber. The blood inlet 8 is provided at the upper part of the side surface of the housing body 73 so as to communicate with the upper part of the first blood chamber 7a (blood chamber on the blood inflow side). Blood chamber 7b
The lower part of the side surface of the housing body 73 is provided so as to communicate with the lower part of the (blood chamber on the blood outflow side).

The two inner wall portions 73a and 73b are formed as shown in FIG.
As shown in FIG. 13, it is formed at a position facing the center of the tubular hollow fiber membrane bundle 2 and further extends parallel to the axial direction of the hollow fiber membrane bundle. Two inner wall parts 7
3a and 73b are also parallel. For this reason, the blood chamber 7 which is a cylindrical space formed between the outer peripheral surface of the cylindrical hollow fiber membrane bundle 2 and the inner surface of the cylindrical housing main body 73 is 2
The two inner wall portions 73a and 73b are vertically divided into two in the axial direction, and are divided into two substantially equally (so as to be half). Note that the division form is not limited to such an equal division. For example, similarly to the one shown in FIG. 7, the first blood chamber 7a on the blood inflow side is narrow and the second The blood chamber 7b may be widened, or vice versa. Assuming that the area of the outer peripheral surface of the cylindrical hollow fiber membrane bundle 2 is 100, the area of the outer peripheral surface of the cylindrical hollow fiber membrane bundle 2 on the first blood chamber 7a side and the cylinder on the second blood chamber 7b side The ratio of the area of the outer peripheral surface of the hollow fiber membrane bundle 2 is preferably about 30:70 to 70:30. The width of the inner wall portions 73a, 73b in close contact with the tubular hollow fiber membrane bundle 2 (the width of the contact portion of the inner wall portion with the tubular hollow fiber membrane bundle) is preferably small. Since it causes a short circuit, the length is preferably 20 to 90 mm, preferably about 20 to 50 mm. In other words, the inner wall portions 73 a and 73 b cover the outer surface of the tubular hollow fiber membrane bundle 2. The area is preferably about 5 to 20% of the area of the outer surface of the tubular hollow fiber membrane bundle 2.

Also in this artificial lung 70, as shown in FIGS. 9 and 10, two inner wall portions 73a, 73
An opening non-forming portion 31a extending in the axial direction is provided on the side surface of the inner cylindrical member 31 corresponding to the portion where b is located. Therefore, the tubular hollow fiber membrane bundle 2 is formed by the non-opening portion 31a of the inner tubular member 31 and the inner wall portions 73a and 73b.
Since the compression can be performed, the close contact of the tubular hollow fiber membrane bundle 2 of the partitioning member is further ensured.

Also in the artificial lung 70, most of the blood that has flowed through the blood inlet 8 flows into the first blood chamber 7a, and the part of the blood that is exposed in the first blood chamber 7a. The tubular hollow fiber membrane bundle 2 penetrates into the tubular hollow fiber membrane bundle 2 from the outer surface thereof, passes through the tubular hollow fiber membrane bundle 2, and has an inner tubular member 3.
Through one opening, it flows into the blood circulation part 7c. At this time, blood is gas-exchanged to some extent. Then, from the blood inflow portion, through the opening 32 of the inner cylindrical member 31, the blood enters the membrane bundle from the inner surface side of the hollow fiber membrane bundle on the second blood chamber 7b side, and the cylindrical hollow fiber It passes through the membrane bundle 2 and flows into the second blood chamber 7b. At this time, the blood is gas-exchanged again. The blood that has flowed into the second blood chamber 7b flows out of the blood outlet 9.

Next, the hollow fiber membrane oxygenator 80 of the embodiment shown in FIGS. 14 and 15 will be described. FIG. 14 is a cross-sectional view showing another embodiment of the hollow fiber membrane oxygenator of the present invention, and FIG. 15 is a cross-sectional view taken along line HH of FIG. The basic configuration of the hollow fiber membrane oxygenator 80 is the same as that of the oxygenator 50 of the embodiment shown in FIGS. 5 and 6 and described above. To
The only difference is that the partition member 85 is provided. For this reason, common parts are denoted by the same reference numerals, and the description thereof refers to those described above. Further, the hollow fiber membrane oxygenator 80
Also, since the basic configuration is the same as that of the oxygenator 1 of the embodiment shown in FIG. 1 and described above, common portions are denoted by the same reference numerals, and the description thereof will refer to those described above.

In the artificial lung 80 of this embodiment, the partition member 8
Reference numeral 5 denotes an annular body formed near the center of the cylindrical hollow fiber membrane bundle 2 in the axial direction. In the oxygenator 80, the blood chamber 7, which is a cylindrical space formed between the outer peripheral surface of the cylindrical hollow fiber membrane bundle 2 and the inner surface of the cylindrical housing main body 83, is formed by the annular partition member 85. It is divided into a first blood chamber 7a on the side and a second blood chamber 7b on the other partition 6 side. That is, the blood chamber 7 is vertically divided into two with respect to the axial direction of the housing. Annular partitioning member 85
As shown in FIG. 5, it is preferable to be orthogonal to the central axis of the cylindrical housing main body 83, but it may be formed to be inclined at a predetermined angle with respect to the central axis. In this embodiment, the upper first blood chamber 7a forms a blood inflow side blood chamber, and the second blood chamber 7b forms a blood outflow side blood chamber. The blood inlet 8 is provided at the upper portion of the side surface of the housing body so as to communicate with the upper portion of the first blood chamber 7a (blood inflow side blood chamber), and the blood outlet 9 is provided with the second blood chamber 9a. The lower part of the side surface of the housing body is provided so as to communicate with the lower part of the chamber 7b (blood chamber on the blood outflow side).

This annular partitioning member 85 is the same as the above-mentioned 6 in FIG.
Materials similar to 3a and 63b can be suitably used. Also,
The annular partition member 85 is not limited to a member formed separately from the tubular housing main body 83, but may be formed by the above-described members 63a and 63a in FIG.
63b, the annular partition member 85 is formed integrally with the cylindrical housing body 83 by two-color molding,
Alternatively, it may be formed integrally by so-called insert molding in which a tubular housing main body 83 is formed by inserting a preformed elastic member into a mold.

When the partition member 85 is formed in a part of the housing using the two-color molding and the insert molding, it is preferable that the material forming the housing body and the material forming the partition member have adhesiveness. As the material for forming the housing body and the partition member when the two-color molding method is used, those described above can be used.

The annular partitioning member 85 has elasticity, and its distal end has a shape that can be in close contact with the outer surface of the tubular hollow fiber membrane bundle as shown in FIG. For this reason, the partition member 85 is almost liquid-tightly adhered to the outer surface of the tubular hollow fiber membrane bundle 2. By the annular partition member 85, the blood chamber 7
Is divided into a blood chamber 7a and a second blood chamber 7b, and the first blood chamber and the second blood chamber are in contact with the hollow fiber membrane from one blood chamber to the other blood chamber. It is partitioned so as not to circulate. That is, blood chamber 7
Is to prevent a blood flow from flowing from the first blood chamber 7a to the second blood chamber 7b (or from the second blood chamber to the first blood chamber) without contact with the hollow fiber membrane. , And an annular partition member 85. In addition,
In the artificial lung 80, since the inside of the tubular hollow fiber membrane bundle 2 is not partitioned, the inside of the tubular hollow fiber membrane bundle 2 does not flow into the blood circulation portion 7c, and is located inside the annular partition member 85 from the first blood chamber. There is also a possibility that blood slightly flows into the second blood chamber through the inside of the hollow fiber membrane bundle 2. However, since the blood volume is extremely small and at least in contact with the hollow fiber membrane, gas exchange of blood is performed, so that there is no particular problem.

In this embodiment, the annular partition member 8
5, the blood chamber 7 is divided into two substantially equal parts. However, the division form is not limited to such an equal part. Blood chamber 7
a may be narrow and the side of the second blood chamber 7b may be wide, or vice versa. Assuming that the area of the outer peripheral surface of the cylindrical hollow fiber membrane bundle 2 is 100, the area of the outer peripheral surface of the cylindrical hollow fiber membrane bundle 2 on the first blood chamber 7a side and the cylinder on the second blood chamber 7b side The ratio of the area of the outer peripheral surface of the hollow fiber membrane bundle 2 is 30:70.
About 70:30 is suitable.

The width of the annular partitioning member 85 is preferably narrow, but if it is too narrow, it causes a short circuit of blood. Therefore, the width is preferably 20 to 90 mm, preferably about 20 to 50 mm. Using the expression, the annular partition member 85
However, the area covering the outer surface of the tubular hollow fiber membrane bundle 2 is preferably about 5 to 20% of the area of the outer surface of the tubular hollow fiber membrane bundle 2.

Also in this artificial lung 80, as shown in FIGS. 5 and 6, the side surface of the inner cylindrical member 51 corresponding to the portion where the partition member 85 is formed has a predetermined width and has an annular shape. The formed non-opening portion 51a is provided. Therefore, the tubular hollow fiber membrane bundle 2 can be compressed by the non-opening portion 31a of the inner tubular member 31 and the partitioning member 85.
The close adherence of the tubular hollow fiber membrane bundle 2 of the partition member is more reliable.

In the oxygenator 80, most of the blood that has flowed through the blood inlet 8 flows into the first blood chamber 7a, and the part of the blood that is exposed in the first blood chamber 7a The tubular hollow fiber membrane bundle 2 penetrates into the tubular hollow fiber membrane bundle 2 from the outer surface thereof, passes through the tubular hollow fiber membrane bundle 2, and has an inner tubular member 3.
Through one opening, it flows into the blood circulation part 7c. At this time, blood is gas-exchanged to some extent. Then, from the blood inflow portion, through the opening 32 of the inner cylindrical member 31, the blood enters the membrane bundle from the inner surface side of the hollow fiber membrane bundle on the second blood chamber 7b side, and the cylindrical hollow fiber It passes through the membrane bundle 2 and flows into the second blood chamber 7b. At this time, the blood is gas-exchanged again. The blood that has flowed into the second blood chamber 7b flows out of the blood outlet 9.

[0065]

EXAMPLES Next, specific examples and comparative examples of the hollow fiber membrane oxygenator of the present invention will be described. (Example) As the inner cylindrical member, two non-opening portions 51 having an outer diameter of 50 mm, a length of 188 mm, a large number of openings on the side surface, and extending in the axial direction as shown in FIG.
Those having a were used. This inner cylindrical member has an inner diameter of 1
Four porous polypropylene hollow fiber membranes each having a diameter of 95 μm, an outer diameter of 295 μm, and a porosity of about 35% are wound around the hollow fiber membrane at a spacing of 50 μm. The hollow fiber membrane was wound so that the spacing between the previously wound hollow fiber membranes would be the same, and the spacing between adjacent hollow fiber membranes would be constant, to form a hollow fiber bobbin. Then, two partition walls each having a width of mm were formed with a potting agent at a position substantially facing the side surface of the hollow fiber bobbin and on a portion where the opening of the inner cylindrical body was not formed. Then, before the potting agent forming the partition wall is completely solidified, the hollow fiber membrane bobbin is stored in the cylindrical housing main body 33, and the inner cylindrical body is further stored in the hollow fiber bobbin. After fixing with a potting agent, cutting was performed. A gas inflow member and a gas outflow member are attached to the artificial lung, which is provided with a tubular hollow fiber membrane bundle having a form as shown in FIGS. 1, 2 and 3, and has a membrane area of 2.1 m ² and a blood filling amount of 210 ml. It was created.

Comparative Example An artificial lung of a comparative example was prepared in the following manner. The outer diameter of the inner cylindrical member is 8
mm and a length of 188 mm were used. An inner diameter of 195 μm, an outer diameter of 295 μm, and a porosity of about 35
% Porous polypropylene hollow fiber membranes are wound with the spacing between the four hollow fiber membranes kept constant, and the spacing between the next adjacent hollow fiber membranes is also the same as the spacing between the previously wound hollow fiber membranes. The hollow fiber membrane was wound so that the interval between adjacent hollow fiber membranes was constant, and a hollow fiber membrane bobbin was formed. Then, the hollow fiber membrane bobbin is housed in the outer tubular member, and one end is fixed with a potting agent and then cut.
Furthermore, after inserting the inner cylindrical body inside the hollow fiber membrane bobbin,
The other end was fixed by a potting agent, and the other end of the fixed hollow fiber membrane bobbin was cut without cutting the inner cylinder while rotating about the inner cylinder. Then, attach the gas inlet member and the gas outlet member, comprises a cylindrical hollow fiber membrane bundle in the form as shown in FIG. 16, membrane area 2.1 m ^2,
An artificial lung 90 with a blood filling volume of 220 ml was prepared.

(Experiment) The following experiments were performed using the bovine blood for the artificial lungs of the examples and the comparative examples prepared as described above. Bovine blood was collected from AMMI (Associa).
Tion for the Advance of M
Using standard venous blood as determined by an electrical instrumentation, an anticoagulant was added to the venous blood, and the mixture was refluxed to each artificial lung at a flow rate of 7 L / min. Then, for each oxygenator, blood is collected near the blood inlet and the blood outlet, and the oxygen gas partial pressure, carbon dioxide partial pressure, pH, etc. are determined by a blood gas analyzer, and the oxygen transfer amount and the carbon dioxide transfer are determined. The amount was determined. In addition, blood flow 7L
/ Min pressure loss was measured. The results were as shown in Table 1 below.

[0068]

[Table 1]

[0069]

The hollow fiber membrane-type artificial lung of the present invention comprises a plurality of hollow fiber membranes for gas exchange, and a tubular hollow fiber membrane bundle forming a blood circulation part therein, and the tubular hollow fiber membrane bundle. And a housing for fixing both ends of the tubular hollow fiber membrane bundle to the housing with both ends of the hollow fiber membrane open.
A hollow fiber membrane oxygenator having two partition walls and a gas inlet and a gas outlet communicating with the inside of the hollow fiber membrane,
The housing has a cylindrical housing main body, and the inside of the artificial lung includes a blood chamber formed between an outer peripheral surface of the cylindrical hollow fiber membrane bundle and an inner surface of the cylindrical housing main body, and The chamber is partitioned into a first blood chamber and a second blood chamber, and the first blood chamber and the second blood chamber are configured such that blood is transferred from one blood chamber to the other blood chamber by the hollow fiber membrane. And the cylindrical housing main body has a side face with a blood inflow port communicating with one of the first blood chamber or the second blood chamber and the first blood chamber and the first blood chamber. And a blood outlet communicating with the other one of the blood chambers or the second blood chamber. Therefore, according to the oxygenator of the present invention, the formation of non-uniform blood flow is small, the gas exchange efficiency is sufficient, and the pressure loss is low.

[Brief description of the drawings]

FIG. 1 is a cross-sectional view showing one embodiment of a hollow fiber membrane oxygenator of the present invention.

FIG. 2 is a sectional view taken along line AA of FIG. 1;

FIG. 3 is a sectional view taken along line BB of FIG. 1;

FIG. 4 is a front view showing an example of an inner cylindrical member used for the hollow fiber membrane-type oxygenator of the present invention.

FIG. 4 is a longitudinal sectional view of the inner tubular member shown in FIG. 3;

FIG. 5 is a cross-sectional view showing another embodiment of the hollow fiber membrane oxygenator of the present invention.

FIG. 6 is a sectional view taken along line CC of FIG. 5;

FIG. 7 is a cross-sectional view showing another embodiment of the hollow fiber membrane oxygenator of the present invention.

FIG. 8 is a cross-sectional view showing another embodiment of the hollow fiber membrane-type oxygenator of the present invention.

FIG. 9 is a sectional view taken along line DD of FIG. 8;

FIG. 10 is a sectional view taken along line EE of FIG. 8;

FIG. 11 is a cross-sectional view showing another embodiment of the hollow fiber membrane oxygenator of the present invention.

FIG. 12 is a sectional view taken along line FF of FIG. 11;

FIG. 13 is a sectional view taken along line GG of FIG. 11;

FIG. 14 is a cross-sectional view showing another embodiment of the hollow fiber membrane oxygenator of the present invention.

FIG. 15 is a sectional view taken along line HH of FIG. 14;

FIG. 16 is a sectional view showing a hollow fiber membrane-type oxygenator of a comparative example.

[Explanation of symbols]

 Reference Signs List 1 hollow fiber membrane oxygenator 2 tubular hollow fiber membrane bundle 3 housing 4a, 4b partition wall 5, 6 partition wall 50 hollow fiber membrane oxygenator 55 annular partition wall

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[Procedure amendment]

[Submission date] July 17, 1997

[Procedure amendment 1]

[Document name to be amended] Statement

[Correction target item name] Brief description of drawings

[Correction method] Change

[Correction contents]

[Brief description of the drawings]

FIG. 1 is a cross-sectional view showing one embodiment of a hollow fiber membrane oxygenator of the present invention.

FIG. 2 is a sectional view taken along line AA of FIG. 1;

FIG. 3 is a sectional view taken along line BB of FIG. 1;

FIG. 4 is a front view showing an example of an inner cylindrical member used for the hollow fiber membrane-type oxygenator of the present invention.

FIG. 5 is a cross-sectional view showing another embodiment of the hollow fiber membrane oxygenator of the present invention.

FIG. 6 is a sectional view taken along line CC of FIG. 5;

FIG. 7 is a cross-sectional view showing another embodiment of the hollow fiber membrane oxygenator of the present invention.

FIG. 8 is a cross-sectional view showing another embodiment of the hollow fiber membrane-type oxygenator of the present invention.

FIG. 9 is a sectional view taken along line DD of FIG. 8;

FIG. 10 is a sectional view taken along line EE of FIG. 8;

FIG. 11 is a cross-sectional view showing another embodiment of the hollow fiber membrane oxygenator of the present invention.

FIG. 12 is a sectional view taken along line FF of FIG. 11;

FIG. 13 is a sectional view taken along line GG of FIG. 11;

FIG. 14 is a cross-sectional view showing another embodiment of the hollow fiber membrane oxygenator of the present invention.

FIG. 15 is a sectional view taken along line HH of FIG. 14;

FIG. 16 is a sectional view showing a hollow fiber membrane-type oxygenator of a comparative example.

[Description of Signs] 1 Hollow fiber membrane oxygenator 2 Tubular hollow fiber membrane bundle 3 Housing 4a, 4b Partition wall 5, 6 Partition wall 50 Hollow fiber membrane oxygenator 55 Ring partition wall

Claims (10)

[Claims] 1. A tubular hollow fiber membrane bundle comprising a large number of hollow fiber membranes for gas exchange and forming a blood circulation part therein, a housing for accommodating the tubular hollow fiber membrane bundle, and a hollow fiber membrane A hollow fiber membrane type having two partition walls for fixing both ends of the tubular hollow fiber membrane bundle to the housing with both ends opened, and a gas inlet and a gas outlet communicating with the inside of the hollow fiber membrane. An artificial lung, wherein the housing has a cylindrical housing main body, and the inside of the artificial lung includes a blood chamber formed between an outer peripheral surface of the cylindrical hollow fiber membrane bundle and an inner surface of the cylindrical housing main body. And the blood chamber is partitioned into a first blood chamber and a second blood chamber, and the first blood chamber and the second blood chamber are provided in one blood chamber to the other blood chamber. It is partitioned so that blood does not flow without contacting the hollow fiber membrane. Then, the cylindrical housing body,
A side surface has a blood inlet communicating with one of the first blood chamber or the second blood chamber and a blood outlet communicating with the other of the first blood chamber or the second blood chamber. The hollow fiber membrane type artificial lung. 2. The artificial lung according to claim 1, wherein the first blood chamber and the second blood chamber communicate with each other through a blood circulation part formed substantially inside the tubular hollow fiber membrane bundle. The hollow fiber membrane-type artificial oxygenator according to claim 1, further comprising a partition wall. 3. The hollow fiber membrane oxygenator comprises two partition walls extending from the one partition to the other partition,
The hollow fiber membrane-type artificial lung according to claim 1 or 2, wherein the cylindrical blood chamber is vertically divided into two in the axial direction by the two partition walls. 4. The partition wall is an annular partition wall formed near an axial center of the cylindrical housing body,
3. The hollow fiber membrane according to claim 2, wherein the blood chamber is partitioned by the annular partition wall into a first blood chamber on one partition wall side and a second blood chamber on the other partition wall side. 4. Type artificial lung. 5. The housing has a partition member or an inner wall portion which is substantially in close contact with the hollow fiber membrane bundle in a liquid-tight manner, and the blood chamber is formed by the partition member or the inner wall portion.
The hollow fiber membrane-type artificial lung according to claim 1, wherein the hollow fiber membrane-type artificial lung is partitioned into a blood chamber and a second blood chamber. 6. Two partition members or inner wall portions that are substantially liquid-tightly adhered to the hollow fiber membrane bundle are formed so as to extend from the one partition wall to the other partition wall. The hollow fiber membrane-type artificial lung according to claim 5, wherein the cylindrical blood chamber is vertically divided into two by an inner wall portion. 7. A partition member or an inner wall portion which comes into close contact with the hollow fiber membrane bundle almost in a liquid-tight manner is formed in an annular shape near a central portion in the axial direction of the cylindrical housing main body. The hollow fiber membrane-type artificial body according to claim 5, wherein the blood chamber is divided into a first blood chamber on one partition wall side and a second blood chamber on the other partition wall side by the inner wall portion. lung. 8. An area in which the partition wall or the partition member or the inner wall portion which is almost liquid-tightly adhered to the hollow fiber membrane bundle covers the outer surface of the hollow fiber membrane bundle, is equal to the outer surface of the hollow fiber membrane bundle. The hollow fiber membrane-type artificial lung according to any one of claims 2 to 7, which accounts for 5 to 20% of the area. 9. The housing has an inner cylindrical member having a blood circulation opening on a side surface, and the hollow fiber membrane bundle is wound around an outer surface of the inner cylindrical member,
The hollow fiber membrane-type artificial lung according to any one of claims 1 to 8, wherein the inner cylindrical member is fixed to the cylindrical housing body by the partition. 10. The hollow fiber membrane bundle, wherein the hollow fiber membrane is
10. The method according to claim 1, wherein one or a plurality of the hollow fiber membranes are simultaneously wound around the inner tubular member so that all the hollow fiber membranes have a substantially constant interval. The hollow fiber membrane type oxygenator according to the above.