CN112007519A - Oxygenation membrane, preparation method thereof and oxygenation assembly - Google Patents

Oxygenation membrane, preparation method thereof and oxygenation assembly Download PDF

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Publication number
CN112007519A
CN112007519A CN202010827760.5A CN202010827760A CN112007519A CN 112007519 A CN112007519 A CN 112007519A CN 202010827760 A CN202010827760 A CN 202010827760A CN 112007519 A CN112007519 A CN 112007519A
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membrane
hollow fiber
layer
raw material
fiber membrane
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CN112007519B (en
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贾建东
陈梦泽
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Hangzhou Kebaite Technology Co ltd
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Hangzhou Kebaite Technology Co ltd
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/08—Hollow fibre membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/021—Manufacturing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/10—Spiral-wound membrane modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/10—Spiral-wound membrane modules
    • B01D63/103—Details relating to membrane envelopes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D67/00—Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
    • B01D67/0002—Organic membrane manufacture
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/12—Composite membranes; Ultra-thin membranes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
    • Y02W10/00—Technologies for wastewater treatment
    • Y02W10/10—Biological treatment of water, waste water, or sewage

Abstract

The invention relates to an oxygenation membrane, which comprises a membrane layer consisting of a plurality of hollow fiber membrane filaments, wherein the membrane layer at least comprises two layers, different membrane layers are stacked to form a stacked membrane layer, and any one hollow fiber membrane filament in the membrane layer is partially overlapped with at least one hollow fiber membrane filament in an adjacent membrane layer in the projection of the hollow fiber membrane filament in the stacking direction. The membrane layer comprises an inclined membrane layer, the edge connecting lines of all hollow fiber membrane filaments at the same end in the inclined membrane layer are straight lines, and at least one section of the hollow fiber membrane filaments or the extension lines of the hollow fiber membrane filaments and the straight lines are arranged in an acute angle. The invention aims to provide an oxygenation membrane with higher gas exchange efficiency and better oxygenation effect, a preparation method thereof and an oxygenation assembly.

Description

Oxygenation membrane, preparation method thereof and oxygenation assembly
Technical Field
The invention relates to a gas exchange membrane, in particular to an oxygenation membrane, a preparation method thereof and an oxygenation assembly.
Background
Extracorporeal Membrane Oxygenation (ECMO) is mainly used to provide continuous Extracorporeal respiration and circulation to patients with severe cardiopulmonary failure to sustain the life of the patient. In front of the new crown epidemic situation which is becoming more severe at present, the ECMO technology is of great importance. The ECMO mainly comprises an intravascular cannula, a connecting pipe, a power pump (artificial heart), an oxygenator (artificial lung), an oxygen supply pipe, a monitoring system and the like. The core of which is an oxygenator (artificial lung) to perform oxygen-carbon dioxide exchange and a powered pump (artificial heart) to provide blood flow power.
The working principle is as follows: the venous blood in the body of the patient is led to the oxygenator, the venous blood exchanges oxygen-carbon dioxide in the oxygenator, after the blood flows out of the oxygenator, the oxygen content in the blood is increased, the carbon dioxide content is reduced, the effect of changing the venous blood into arterial blood in vitro is realized, damaged lungs of the patient are replaced, and the life of the patient is maintained. The core component in the oxygenator is the oxygenation membrane, and in order to improve the oxygenation effect and efficiency, the oxygenator and the oxygenation membrane need to be arranged in a related way.
In the prior art, oxygenators are divided into a silica gel membrane type and a hollow fiber type, and for the case that the hollow fiber membrane is used as an oxygenation membrane, the main component of the oxygenation membrane which performs oxygen-carbon dioxide exchange is the hollow fiber membrane. Get single hollow fiber membrane silk and carry out the analysis, in the in-process of work, continuously lead to air or oxygen or other relevant gas in the inside hollow tube of hollow fiber membrane silk, blood surrounds the flow outside the hollow fiber membrane silk, at the in-process that flows, because the inside oxygen content of hollow fiber membrane silk is high, and carbon dioxide content in the blood is low, consequently oxygen can pass the pipe wall diffusion to blood from hollow fiber membrane silk inside, carbon dioxide can pass the pipe wall diffusion to the inside hollow tube of hollow fiber membrane silk in the blood to realize gas exchange's function. In the oxygenator, an oxygenation membrane consisting of a plurality of hollow fiber membrane filaments is included, and blood flows around the hollow fiber membrane filaments. Conventional oxygen-containing membranes are set up as follows: weaving a plurality of hollow fiber membrane filaments into a single-layer net-shaped structure through weaving wires, wherein the hollow fiber membrane filaments and the weaving wires are in a right angle, and then winding the hollow fiber membrane layer of the net-shaped structure to enable the hollow fiber membrane layer to be in a cylindrical shape integrally, wherein one end of the hollow fiber membrane layer is an air inlet end, and the other end of the hollow fiber membrane layer is an air outlet end; it is obvious that in this way, each hollow fiber membrane filament is arranged in parallel, so that the blood flow channel formed between the hollow fiber membrane filaments is also a parallel and uniform flow channel, as shown in fig. 11, wherein the direction of the arrow is the blood flow direction. In the figure, the columnar space enclosed by the dotted line is the blood close to the center of the flow channel, and the flow channel space between the dotted line and the hollow fiber membrane filaments is the part of the blood close to the hollow fiber membrane filaments. Because the whole blood flow channel is approximately in a long-strip column shape, the effect of turbulent flow of blood is not achieved in the flow channel, the blood close to the hollow fiber membrane silk part can exchange gas quickly and efficiently, the blood in the column-shaped flow channel space in the central dotted line can not be well contacted with the hollow fiber membrane silk, and therefore when the blood flowing speed is high, the blood in the part can not exchange gas, and flows out of the oxygenator along the blood flow channel, and the exchange of oxygen and carbon dioxide is influenced. Meanwhile, because the blood flows in the flow channel and contacts with the hollow fiber membrane filaments successively, the blood firstly flows into the blood in the front half part of the flow channel, and the blood is close to the hollow fiber membrane filaments, so that good gas exchange can be performed (namely, the blood in the position of the area A in fig. 11), and because turbulence is basically absent in the flow channel, when the blood continuously flows in the flow channel, the blood which has undergone gas exchange is still in the position close to the hollow fiber membrane filaments (namely, the blood in the position of the area B in fig. 11), so that the gas exchange efficiency of the blood in the back half part of the flow channel is reduced, and the gas exchange cannot be performed efficiently.
Disclosure of Invention
The invention aims to provide an oxygenation membrane with higher gas exchange efficiency and better oxygenation effect, a preparation method thereof and an oxygenation assembly.
In order to achieve the purpose, the invention adopts the following technical scheme: an oxygenation membrane comprises a membrane layer composed of a plurality of hollow fiber membrane filaments, wherein the membrane layer at least comprises two layers, different membrane layers are stacked to form a stacked membrane layer, any one hollow fiber membrane filament in the membrane layer is partially overlapped with at least one hollow fiber membrane filament in an adjacent membrane layer in the projection of the hollow fiber membrane filament in the stacking direction.
By adopting the technical scheme, at least two film layers are adopted as the minimum unit of the oxygen-containing film for winding; and, unparallel between the hollow fiber membrane silk in two adjacent rete when two at least retes are opened and are spread out, partly overlap in the projection on range upon range of direction, such setting compares among the prior art parallel arrangement between the hollow fiber membrane silk, can make form slope, crisscross runner between the hollow fiber membrane silk, can increase the disorder degree of the inside blood flow of oxygenation membrane. This is advantageous in that it is ensured that the blood in the central portion of the blood flow channel can contact the surface of the hollow fiber membrane filaments during the flow, thereby performing gas exchange, i.e., the contact area between the blood and the surface of the hollow fiber membrane filaments is relatively increased, and the gas exchange efficiency is improved. And the blood flow channel formed between the hollow fiber membrane filaments and the hollow fiber membrane filaments has a more complex structure, the larger the turbulence degree is, and the blood can be ensured to be fully contacted with the surfaces of the hollow fiber membrane filaments.
Furthermore, the membranous layer includes the slope membranous layer, the edge connecting line of all hollow fiber membrane silks in the slope membranous layer in same end is the straight line, in the hollow fiber membrane silk at least one section or its extension line and this straight line between be the acute angle setting.
By adopting the technical scheme, the direction of the hollow fiber membrane filaments in the inclined membrane layer is limited. When the oxygen-containing membrane is unfolded and laid flat, the single hollow fiber membrane wire is not vertically arranged but is inclined to a certain degree, so that when the multiple membrane layers are stacked, a certain angle is formed between the hollow fiber membrane wire and the hollow fiber membrane wire, and the turbulence degree of blood is increased.
Furthermore, the hollow fiber membrane filaments in the membrane layer are linear.
Through adopting above-mentioned technical scheme, the hollow fiber membrane silk of linear type is the most common hollow fiber membrane silk to be convenient for weave and follow-up oxygenation subassembly's structural design.
Further, the included angle formed between the hollow fiber membrane filaments and the straight line formed by connecting the edges of the hollow fiber membrane filaments at the same end is set between 45 degrees and 90 degrees.
Further, the laminated film layer is formed by laminating two inclined film layers, and the included angle between the hollow fiber film filaments in the two inclined film layers is set to be 5-90 degrees.
By adopting the technical scheme, the inclination angle of the hollow fiber membrane filaments in the inclined membrane layer and the included angle between the hollow fiber membrane filaments in the two inclined membrane layers are limited; too large an inclination angle can elongate the length of the hollow fiber membrane filaments, too large an inclination can also cause too large resistance in the flow channel, which affects the blood flow rate, and too small an inclination angle may not realize a better turbulent flow effect.
Further, the rete still includes perpendicular rete, the hollow fiber membrane silk is the straight line at the edge line of same end in perpendicular rete, just the hollow fiber membrane silk is the linear type, be the right angle setting between hollow fiber membrane silk and this straight line.
Further, the laminated film layer is formed by laminating three film layers, the middle is a vertical film layer, two sides are inclined film layers, and the included angle between the hollow fiber film filaments in the adjacent film layers is set to be 5-90 degrees.
Through adopting above-mentioned technical scheme, realized the laminated structure of three-layer rete, set up the intermediate level into perpendicular rete, both sides can furthest increase the turbulent flow degree in the oxygenation membrane for the slope rete to can not make the turbulent flow unbalance, can all keep the same or similar turbulent flow state in perpendicular rete both sides, the influence to the membrane structure is reduced to minimumly.
Furthermore, bonding points are arranged among different film layers in the laminated film layer.
By adopting the technical scheme, the arrangement of the bonding points indicates that different film layers are bonded through the positions of some characteristics, wherein the bonding points include but are not limited to bonding points formed by heat sealing, adhesion, electrostatic attraction and the like.
Furthermore, the hollow fiber membrane filaments in the same membrane layer are fixed by weaving with braided wires.
Through adopting above-mentioned technical scheme, it is fixed to have injectd to weave through the braided wire between the hollow fiber membrane silk, can increase the holistic structural strength of rete to be convenient for the preparation of rete.
Furthermore, a fixing groove is formed at the knitting fixing position of the hollow fiber membrane yarn and the knitting yarn.
Further, the depth of the fixing groove is set between 10 μm and 100 μm, and the width of the fixing groove is set between 90 μm and 110 μm.
Further, the depth of the fixing groove is increased along with the reduction of the included angle between the hollow fiber membrane yarn and the braided wire.
Through adopting above-mentioned technical scheme, the setting up of fixed slot can increase the structural strength between hollow fiber membrane silk and the braided wire for braided wire and hollow fiber membrane silk surface can not take place easily and slide, thereby produce harmful effects to membrane silk surface structure. If the inclination angle of the inclined film layer is large, namely the included angle between the hollow fiber film filaments and the braided wire is small, the depth of the fixing groove needs to be made deeper so as to prevent the braided wire from slipping from the fixing groove.
Further, the outer diameter of the hollow fiber membrane yarn is set to be 0.3mm-0.4mm, and the inner diameter is set to be 0.2mm-0.28 mm.
Further, the space between the hollow fiber membrane filaments is set between 0.5mm and 0.75 mm.
By adopting the technical scheme, the number of hollow fiber membrane filaments in the oxygenation membrane and the gas exchange effect of a single membrane filament can be ensured. If the outer diameter of the hollow fiber membrane filament is too large and the inner diameter is too small, the diffusion rate of oxygen and carbon dioxide is very low; if the outer diameter of the hollow fiber membrane filaments is too large and the inner diameter is too large, a large part of air or oxygen in the hollow is wasted; if the outer diameter of the hollow fiber membrane wire is too small and the inner diameter is too large, blood can easily permeate the tube wall of the hollow fiber membrane wire to cause the hollow fiber membrane wire to lose efficacy; if the outer diameter of the hollow fiber membrane wire is too small and the inner diameter is too small, the difficulty of the production process is increased, and the production cost is increased. If the number of hollow fiber membrane filaments in the oxygenation membrane is too large, the blood flow rate is reduced, so that the amount of blood capable of gas exchange is reduced at the same time; if the amount is too small, part of the blood cannot undergo gas exchange and flows through the oxygen-containing membrane, failing to perform the oxygen-carbon dioxide exchange function.
Further, the hollow fiber membrane yarn comprises a loose layer positioned on the inner side and a dense layer positioned on the outer side.
Further, the thickness of the dense layer is set to be between 0.1 and 3 microns, and the thickness of the loose layer is set to be between 47 and 99 microns.
Furthermore, the oxygen mass transfer efficiency of the hollow fiber membrane filaments is 15-400L/(min m)2MPa).
By adopting the technical scheme, the compact layer on the outer side of the hollow fiber membrane yarn can ensure that the permeation speed is very low when blood flows through the outside of the hollow fiber membrane yarn, so that the effective service life of the oxygen-containing membrane is prolonged. If the thickness of the compact layer is too large, although the speed of blood permeating the hollow fiber membrane filaments can be reduced, the oxygen-carbon dioxide exchange rate can be influenced; if the thickness of the dense layer is too small, although the oxygen-carbon dioxide exchange rate is fast, the speed of the hollow fiber membrane filaments permeated by blood is also fast, so that the effective service life is low.
Further, the braided wire includes but is not limited to PP, PET, N6, N66 and their blends, and the gauge is selected from 10F-100F, 10D-60D.
Through adopting above-mentioned technical scheme, limited the material, the thickness of braided wire to guarantee to weave the structural strength of whole oxygenized membrane, be difficult to the fracture damage.
The invention also provides a preparation method of the oxygen-containing membrane, which comprises the following steps: s1: providing a film layer consisting of at least two layers of hollow fiber film filaments; s2: laminating the film layers prepared in the step S1 to form a laminated film layer, wherein in the laminated film layer, any one hollow fiber film filament in any one film layer is partially overlapped with at least one hollow fiber film filament in an adjacent film layer in the projection of the hollow fiber film filament in the laminating direction; s3: shaping; s4: and (4) winding, namely winding the laminated film layer.
By adopting the technical scheme, the mode of laminating different membrane layers is controlled, so that the hollow fiber membrane filaments in the adjacent membrane layers form a staggered structure after being laminated, the turbulence degree of blood flowing through the outside of the hollow fiber membrane filaments is increased, and the oxygen-carbon dioxide exchange efficiency is improved.
Further, the film layer provided in the step S1 is formed by weaving braided wires and hollow fiber film filaments.
By adopting the technical scheme, the membrane layer is formed by weaving the hollow fiber membrane yarns through the braided wire, and the structural strength of the integral oxygen-containing membrane can be improved. Of course, the hollow fiber membrane layer may also be formed without weaving with braided wires, that is, the hollow fiber membrane filaments are simply laid flat and placed into a layer according to a certain regular position, then a layer of hollow fiber membrane filaments is laid flat and placed on the surface of the hollow fiber membrane filaments according to a certain regular position, and then the steps of shaping and rolling are performed.
Further, the membrane layer woven in the step S1 is a vertical membrane layer in which the hollow fiber membrane filaments and the woven wires are perpendicular to each other.
Further, between the step of S1 and the step of S2, a step of diagonal pulling of the vertical membrane into the oblique membrane may be further included.
Through adopting above-mentioned technical scheme, provide the rete of two kinds of different structures, let the outside blood of hollow fiber membrane silk produce the turbulent flow when being convenient for range upon range of.
Further, the concrete operation of the diagonal drawing can be that a rectangular vertical film layer is taken and opened and laid flat, the opposite sides of the vertical film layer are respectively fixed by using a fixing device, and acting force is applied to enable an inclination angle to be generated between the hollow fiber film filaments and the braided wires in the film layer to form an inclined film layer; alternatively, the first and second electrodes may be,
winding the vertical film layer on the surface of the raw material roll to form a raw material roll, opening the raw material roll, fixing one end of the vertical film layer on a winding roll, adjusting the relative positions of the raw material roll and the winding roll to enable the raw material roll and the winding roll to be crossed in the axis direction, unwinding the raw material roll and winding the winding roll to form an inclined film layer.
By adopting the technical scheme, two different methods for obliquely pulling the vertical film layer to form the inclined film layer are provided, and the two methods can be considered as the optimal method considering both the convenience and the cost of the process flow.
Further, the step S2 specifically includes, S2-1: opening and paving a first rectangular inclined film layer; s2-2: opening and paving a second rectangular inclined film layer; s2-3: laminating a first film layer and a second film layer to form a double-layer film layer, wherein the first inclined film web and the second inclined film web have different inclination angles; alternatively, the first and second electrodes may be,
s2-1: opening and paving a first rectangular vertical film layer; s2-2: opening and paving a second rectangular inclined film layer; s2-3: laminating the first film layer and the second film layer to form a double-layer film layer; alternatively, the first and second electrodes may be,
s2-1: taking a rectangular vertical film layer, opening and paving; s2-2: opening and paving another two rectangular inclined film layers; s2-3: and respectively placing the inclined film layers on two sides of the vertical film layer for laminating to form three film layers.
By adopting the technical scheme, the laminated structure scheme of two double-layer film layers and a three-layer film layer is provided. In the double-layer film scheme, two layers can be stacked by inclined films, or one layer can be an inclined film and the other layer can be a vertical film; in the scheme of three film layers, the middle layer is a vertical film layer, and the two film layers on the two sides are inclined film layers. In both of these solutions, the interlacing of the hollow fiber membrane filaments can be achieved, thereby increasing the turbulence effect of the blood as it flows through the oxygenation membrane.
Further, the step S2 includes that S2-4: and (3) carrying out air-blowing heat seal on the double-layer film layer or the three-layer film layer by using a hot air gun.
Further, the temperature of the hot air gun in the step S2-4 is set to be between 60 and 140 ℃.
By adopting the technical scheme, the double-layer film layer or the three-layer film layer can be thermally sealed, and the fixation among different film layers can be ensured. Relative sliding can not occur, so that the relative position of the hollow fiber membrane filaments between different layers is changed, the effect of blood turbulence is weakened, the structural strength of the oxygen-containing membrane can be ensured, and the oxygen-containing membrane is not easy to disperse.
Further, the step S2 specifically includes that S2-1: providing a first raw material roll, a second raw material roll and a winding roll, wherein the axis of the first raw material roll and the axis of the winding roll are arranged in parallel, and the axis of the second raw material roll and the axis of the winding roll are intersected in a different plane; s 2-2: unwinding the film layers on the first raw material roll and the second raw material roll, and flatly laying and laminating the end parts of the film layers and fixing the end parts on the surface of a winding roller; s 2-3: when the first raw material roll and the second raw material roll are unreeled, the wind-up roll is used for reeling up; alternatively, the first and second electrodes may be,
s 2-1: providing a first raw material roll, a second raw material roll and a winding roll, wherein the axis of the first raw material roll and the axis of the winding roll are intersected in a non-coplanar manner, and the axis of the second raw material roll and the axis of the winding roll are intersected in a non-coplanar manner; s 2-2: unwinding the film layers on the first raw material roll and the second raw material roll, and flatly laying and laminating the end parts of the film layers and fixing the end parts on the surface of a winding roller; s 2-3: when the first raw material roll and the second raw material roll are unreeled, the wind-up roll is used for reeling up; alternatively, the first and second electrodes may be,
s 2-1: providing a first raw material roll, a second raw material roll, a third raw material roll and a winding roll, wherein the axis of the first raw material roll is intersected with the axis of the winding roll in a different plane, the axis of the second raw material roll is intersected with the axis of the winding roll in a different plane, and the axis of the third raw material roll is arranged in parallel with the axis of the winding roll; s 2-2: unwinding the film layers on the first raw material roll, the second raw material roll and the third raw material roll, and flatly laying and laminating the end parts of the film layers and fixing the end parts on the surface of a winding roll, wherein the unwound film layer on the third raw material roll is arranged on the middle layer; s 2-3: and when the first material roll, the second material roll and the third material roll are unreeled, the wind-up roll is reeled.
By adopting the technical scheme, the laminated structure scheme of two double-layer film layers and a three-layer film layer is provided. In the double-layer film scheme, two layers can be stacked by inclined films, or one layer can be an inclined film and the other layer can be a vertical film; in the scheme of three film layers, the middle layer is a vertical film layer, and the two film layers on the two sides are inclined film layers. In both of these solutions, the interlacing of the hollow fiber membrane filaments can be achieved, thereby increasing the turbulence effect of the blood as it flows through the oxygenation membrane. In this scheme, can go on simultaneously perpendicular rete draw to one side, range upon range of and the rolling between the different retes, simplify the loaded down with trivial details degree of whole technology step, improved the production efficiency of oxygenation membrane.
Further, the step S2 includes S2-4: and when the raw material roll is unreeled and the wind-up roll is reeled, the hot-pressing roll is used for carrying out rolling compounding on the laminated film layers.
Further, the temperature of the hot pressing roller in the step s2-4 is set to be between 60 ℃ and 140 ℃.
By adopting the technical scheme, the double-layer film layer or the three-layer film layer can be thermally sealed while being rolled, and the fixation among different film layers is ensured. Relative sliding can not occur, so that the relative position of the hollow fiber membrane filaments between different layers is changed, the effect of blood turbulence is weakened, the structural strength of the oxygen-containing membrane can be ensured, and the oxygen-containing membrane is not easy to disperse. Of course, bonding may be performed without selecting a hot press, and other methods such as adhesive bonding and electrostatic bonding may be used.
Further, in the step s2-2, the axes of the first raw material roll and the second raw material roll intersect in a non-coplanar manner.
By adopting the technical scheme, the inclination angle and/or the inclination direction of the film layer rolled out from the first raw material roll and the film layer rolled out from the second raw material roll are different, and the overall turbulence effect of the oxygen-containing film on blood is improved.
The invention also provides an oxygenation assembly, which comprises a shell, wherein the shell is provided with a liquid inlet, a liquid outlet, an air inlet and an air outlet, the air inlet, the air outlet and the interior of the hollow fiber membrane filaments of the oxygenation membrane form an air passage, a cavity is formed between the outer side wall of the hollow fiber membrane filaments and the shell, the liquid inlet, the cavity and the liquid outlet form a flow passage, a single hollow fiber membrane filament is spirally arranged around the winding axis of the oxygenation membrane, and the spiral inclination angles of the hollow fiber membrane filaments in adjacent membrane layers in the oxygenation membrane are different.
Furthermore, the hollow fiber membrane filaments are provided with sealing elements at positions close to the two ends, and the sealing elements are used for sealing the hollow fiber membrane filaments and the shell.
Furthermore, the air inlet is opposite to an opening at one end of the hollow fiber membrane yarn, and the air outlet is opposite to an opening at the other end of the hollow fiber membrane yarn.
By adopting the technical scheme, the air passage and the flow passage in the oxygenation assembly are relatively isolated, blood flows through the outer surface of the hollow fiber membrane wire in the flow passage, air passes through the hollow fiber membrane wire, and oxygen-carbon dioxide gas exchange occurs at the moment. The air inlet and the air outlet are arranged so that air or oxygen can smoothly enter the hollow fiber membrane filaments.
Compared with the prior art, the oxygenation membrane and the oxygenation assembly using the same have the advantages that: 1. has stronger blood turbulence effect, so that the oxygen-carbon dioxide exchange efficiency is higher. 2. The structure is relatively simple and easy to realize. 3. Structural strength between hollow fiber membrane silk and the braided wire is stronger, thereby difficult emergence relative slip damages hollow fiber membrane surface structure.
Compared with the prior art, the preparation method of the oxygen-containing membrane has the advantages that: 1. the preparation process is simple. 2. Several steps in the process can be carried out simultaneously, so that the production time is saved.
Drawings
The invention will be further described with reference to the accompanying drawings in which:
FIG. 1 is a schematic view of the construction of the oxygenation assembly of the present invention;
FIG. 2 is a schematic view of the structure of a film layer without braided wires in the present invention 1;
FIG. 3 is a schematic view of the structure of a film layer without braided wires in the present invention 2;
FIG. 4 is a schematic view of the structure of a woven membrane layer of the present invention 1;
FIG. 5 is a schematic view of the structure of a woven membrane layer of the present invention 2;
FIG. 6 is a schematic view of a testing apparatus for flow rate 1 in the example;
FIG. 7 is a schematic view of a testing apparatus for flow rate 2 in the example;
FIG. 8 is a schematic diagram of the diagonal drawing process 1;
FIG. 9 is a schematic diagram of the diagonal drawing process 2;
FIG. 10 is a schematic diagram of the diagonal drawing process 3;
FIG. 11 is a schematic diagram of a prior art blood channel;
fig. 12 is a schematic view showing a structure of one layer of the oxygen-containing film wound around the rear end portion in the present invention.
In the figure: 1. an air inlet; 2. an air outlet; 3. a liquid inlet; 4. a liquid outlet; 5. hollow fiber membrane filaments; 6. a seal member; 7. weaving wires; 8. a test tube; 9. a fixing device; 10. a raw material roller; 11. and (7) winding the roller.
Detailed Description
In order that the above objects, features and advantages of the present invention can be more clearly understood, a more particular description of the invention will be rendered by reference to the appended drawings. It should be noted that the embodiments and features of the embodiments of the present application may be combined with each other without conflict.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, however, the present invention may be practiced in other ways than those specifically described herein, and therefore the scope of the present invention is not limited by the specific embodiments disclosed below.
The first embodiment is as follows:
a method for preparing an oxygen-containing membrane, comprising the steps of:
s1: a membrane layer consisting of two layers of hollow fiber membrane filaments 5 is provided. Each layer of film is formed by weaving through weaving equipment by a weaving wire 7, and the weaving wire 7 and the hollow fiber film yarn 5 are arranged at an angle of 90 degrees. Of course, in other embodiments, the film provided herein may also be a film formed by arranging a plurality of single hollow fiber film filaments 5 in the same plane through a stent, that is, a film scheme not including the braided wire 7 (as shown in fig. 2-3).
S2: the two film layers provided in S1 were stacked at different angles. The different angles specifically mean that the arrangement direction of the hollow fiber membrane filaments 5 in one layer of membrane layer is different from the arrangement direction of the hollow fiber membrane filaments 5 in the other layer of membrane layer. Which partially overlap in their projection in the stacking direction. That is, the arrangement of the hollow fiber membrane filaments 5 in the two membrane layers cannot be completely the same. In the present embodiment, the hollow fiber membrane thread 5 itself is also provided in a straight line type, but in other embodiments, the hollow fiber membrane thread 5 itself may be a curve, a broken line, or other irregular shape, etc. (as shown in fig. 4-5).
S3: and (4) shaping, namely blowing the laminated films through a hot air gun so that the two films are relatively fixed through a joint. And the temperature of the hot air gun is limited to be set between 60 ℃ and 140 ℃, and in the embodiment, the temperature of the hot air gun is selected to be 60 ℃. The bonding points are the points for fixing and connecting the two film layers, and in other embodiments, the different film layers may be shaped by gluing, electrostatic adsorption, or the like.
S4: and (4) winding, namely winding the laminated film layer.
The above method is a method for preparing an oxygen-containing membrane formed by laminating two vertical membrane layers. If there are three layers, then only three layers are provided in step S1, and the operation is performed in a similar manner.
In the present embodiment, the membrane layer provided in step S1 has hollow fiber membrane filaments 5 constituting the membrane layer having an outer diameter of 0.4mm and an inner diameter of 0.2mm, and the pitch of the hollow fiber membrane filaments 5 within the membrane layer is set to 0.5 mm. And a fixing groove for fixing the braided wire 7 is opened on the surface of the hollow fiber membrane yarn 5, the depth of the fixing groove is set to be 100 μm, and the width is set to be 105 μm. Further, the inner side of the hollow fiber membrane yarn 5 is set as a dense layer, the outer layer is a loose layer, the thickness of the loose layer is set as 55 μm, the thickness of the dense layer is set as 0.5 μm, and the oxygen mass transfer efficiency of the hollow fiber membrane yarn 5 is 15L/(min m)2Bar). Further, in the present embodiment, the film layers are woven by using PP weaving yarns 7, and the specification is selected to be 10F 10D.
Example two:
s1: a membrane layer consisting of two layers of hollow fiber membrane filaments 5 is provided. Each layer of film is formed by weaving through weaving equipment by a weaving wire 7, and the weaving wire 7 and the hollow fiber film yarn 5 are arranged at an angle of 90 degrees.
And carrying out oblique pulling operation on the membrane layer to form an inclined membrane layer. The concrete diagonal pulling operation is as follows: a rectangular vertical film layer is opened and laid flat, opposite sides of the vertical film layer are respectively fixed by using a fixing device 9, and acting force is applied to enable an inclined angle to be generated between the hollow fiber film filaments 5 and the braided wires 7 in the film layer to form an inclined film layer. The inclination angle of the inclined film layer can be controlled by controlling the inclined pulling degree, and the specific inclination angle is set between 45 degrees and 60 degrees, as shown in fig. 8. In this embodiment, two-layer rete all is through drawing the operation to one side, and inclination all sets up to 45. In other embodiments, the tilt angle may also be 50 °, 55 °, 60 °, and so on.
S2-1: opening and paving a first rectangular inclined film layer with an inclination angle of 45 degrees;
s2-2: opening and paving a second rectangular inclined film layer with an inclination angle of 45 degrees;
s2-3: and laminating the first film layer and the second film layer to form a double-layer film layer. It should be noted here that although the inclination angles of the first inclined film layer and the second inclined film layer are both 45 °, the first inclined film layer and the second inclined film layer are stacked one on top of the other when stacked, so as to ensure that the hollow fiber membrane filaments 5 in the first film layer and the hollow fiber membrane filaments 5 in the second film layer are not completely overlapped. It is therefore understood that the inclination angles of the inclined film layers are 45 ° and 135 °.
S3: and (4) shaping, namely blowing the laminated films through a hot air gun so that the two films are relatively fixed through a joint. And the temperature of the hot air gun is limited to be set between 60 ℃ and 140 ℃, and in the embodiment, the specific temperature of the hot air gun is selected to be 80 ℃.
S4: and (4) winding, namely winding the laminated film layer.
The method is a preparation method of the oxygen-containing membrane, wherein two layers of vertical membrane layers are firstly subjected to inclined pulling and then are laminated. In the case of three layers, it is only necessary to provide three layers in step S1, and the operation is performed in a similar manner, in the case of three layers, it is preferable that the middle layer is a vertical layer, and two sides of the vertical layer are inclined layers, and the inclination angles are the same.
In the present embodiment, the membrane layer provided in step S1 has hollow fiber membrane filaments 5 constituting the membrane layer having an outer diameter of 0.38mm and an inner diameter of 0.28mm, and the pitch of the hollow fiber membrane filaments 5 within the membrane layer is set to 0.62 mm. And a fixing groove for fixing the braided wire 7 is opened on the surface of the hollow fiber membrane yarn 5, the depth of the fixing groove is set to be 80 μm, and the width is set to be 105 μm. Further, the inner side of the hollow fiber membrane yarn 5 is set as a dense layer, the outer layer is a loose layer, the thickness of the loose layer is set as 47 microns, the thickness of the dense layer is set as 3 microns, and the oxygen mass transfer efficiency of the hollow fiber membrane yarn 5 is 104L/(min m & lt/m & gt)2Bar). Further, in the present embodiment, the film layers are woven by using PP weaving yarns 7, and the specification is selected to be 50F 20D.
Example three:
s1: a membrane layer consisting of two layers of hollow fiber membrane filaments 5 is provided. Each layer of film is formed by weaving through weaving equipment by a weaving wire 7, and the weaving wire 7 and the hollow fiber film yarn 5 are arranged at an angle of 90 degrees.
And carrying out oblique pulling operation on the membrane layer to form an inclined membrane layer. The concrete diagonal pulling operation is as follows: a rectangular vertical film layer is opened and laid flat, opposite sides of the vertical film layer are respectively fixed by using a fixing device 9, and acting force is applied to enable an inclined angle to be generated between the hollow fiber film filaments 5 and the braided wires 7 in the film layer to form an inclined film layer. The inclination angle of the inclined film layer can be controlled by controlling the inclined pulling degree, and the specific inclination angle is set between 45 degrees and 60 degrees. In this embodiment, only one of the two layers of films is selected for diagonal pulling, and the inclination angle is set to 45 °. In other embodiments, the tilt angle may also be 50 °, 55 °, 60 °, and so on.
S2-1: opening and paving a first rectangular vertical film layer;
s2-2: opening and paving a second rectangular inclined film layer with an inclination angle of 45 degrees;
s2-3: and laminating the first film layer and the second film layer to form a double-layer film layer. It should be noted here that although the inclination angles of the first inclined film layer and the second inclined film layer are both 45 °, the first inclined film layer and the second inclined film layer are stacked one on top of the other when stacked, so as to ensure that the hollow fiber membrane filaments 5 in the first film layer and the hollow fiber membrane filaments 5 in the second film layer are not completely overlapped. It is therefore understood that the inclination angles of the inclined film layers are 45 ° and 135 °.
S3: and (4) shaping, namely blowing the laminated films through a hot air gun so that the two films are relatively fixed through a joint. And the temperature of the hot air of the heat gun is limited to be set between 60 ℃ and 140 ℃, and in the embodiment, the temperature of the heat gun is selected to be 100 ℃.
S4: and (4) winding, namely winding the laminated film layer.
The preparation method is that a layer of vertical film layer is firstly inclined and then laminated with the vertical film layer to form the oxygen-containing film. If there are three layers, then only three layers are provided in step S1, and the operation is performed in a similar manner.
In the present embodiment, the membrane layer provided in step S1 has hollow fiber membrane filaments 5 constituting the membrane layer having an outer diameter of 0.3mm and an inner diameter of 0.2mm, and the pitch of the hollow fiber membrane filaments 5 within the membrane layer is set to 0.75 mm. And a fixing groove for fixing the braided wire 7 is opened on the surface of the hollow fiber membrane yarn 5, and the depth of the fixing groove is set to be 60 μm and the width is set to be 100 μm. Further, the inner side of the hollow fiber membrane yarn 5 is set as a dense layer, the outer layer is a loose layer, the thickness of the loose layer is set as 99 μm, the thickness of the dense layer is set as 0.1 μm, and the oxygen mass transfer efficiency of the hollow fiber membrane yarn 5 is 234L/(min m)2Bar). Further, in the present embodiment, the film layers are woven by PET weaving yarns 7, and the specification thereof is selected to be 100F 40D.
Example four:
s1: a membrane layer consisting of two layers of hollow fiber membrane filaments 5 is provided. Each layer of film is formed by weaving through weaving equipment by a weaving wire 7, and the weaving wire 7 and the hollow fiber film yarn 5 are arranged at an angle of 90 degrees.
And (3) performing oblique-pulling operation on the membrane layer to form an oblique membrane layer, wherein an operation schematic diagram of oblique pulling of the single-layer vertical membrane net is shown in fig. 9. The concrete diagonal pulling operation is as follows: providing a raw material roller 10, winding the vertical film layer on the surface of the raw material roller 10 to form a raw material roller, opening the raw material roller, fixing one end of the vertical film layer on a winding roller 11, adjusting the relative positions of the raw material roller and the winding roller 11 to enable the raw material roller and the winding roller 11 to intersect in the axial direction, and simultaneously winding the winding roller 11 to form the inclined film layer roll. Because of the double-layer film layer, two material rollers 10 and one wind-up roller 11 need to be provided for operation in this embodiment. In this embodiment, the angle between one of the material rolls 10 and the wind-up roll 11 is set to 45 °, and the angle between the other material roll 10 and the wind-up roll 11 is set to 50 °. Of course, in other embodiments, this angle may be selected according to different requirements, and preferably ranges between 45 ° and 60 °. In order to adjust the inclination angle of the inclined film layer, besides one way of adjusting the angle between the raw material roll and the winding roll 11, in other embodiments, the inclined pulling angle may be adjusted by adjusting the position where the end portion of the vertical film layer pulling-out raw material roll is fixed on the winding roll 11, as shown in fig. 10, or the inclined pulling angle may be adjusted by using a mixture of two ways.
Simultaneously rolling, performing roll lamination on the laminated film layers by using a hot press roll, and setting the temperature of the hot press roll between 60 ℃ and 140 ℃, preferably 120 ℃. In a specific arrangement, the hot-pressing roller may be a bonding inclined film roll, or may be a roller between a raw material roll and an inclined film roll.
In this example, a method of producing a two-layer film stack is described. Compared with the first embodiment to the third embodiment, the method is equivalent to simultaneously and jointly performing the step S2, the step S3 and the step S4, and the production efficiency is improved.
In the present embodiment, the membrane layer provided in step S1 has hollow fiber membrane filaments 5 constituting the membrane layer having an outer diameter of 0.3mm and an inner diameter of 0.2mm, and the pitch of the hollow fiber membrane filaments 5 within the membrane layer is set to 0.55 mm. And the surface of the hollow fiber membrane yarn 5 is provided with a fixing groove for fixing the braided wire 7, the depth of the fixing groove is set to be 80 μm, and the width is 110 μm. Further, the inner side of the hollow fiber membrane yarn 5 is arranged to be a compact layer, the outer layer is a loose layer, and the loose layerThe thickness of the hollow fiber membrane filament 5 is set to be 60 mu m, the thickness of the compact layer is set to be 2 mu m, and the oxygen mass transfer efficiency of the hollow fiber membrane filament 5 is 349L/(min m2Bar). Further, in the present embodiment, the film layers are woven by the N6 knitting yarn 7, and the gauge is selected to be 10F 60D.
Example five:
s1: a membrane layer consisting of three layers of hollow fiber membrane filaments 5 is provided. Each layer of film is formed by weaving through weaving equipment by a weaving wire 7, and the weaving wire 7 and the hollow fiber film yarn 5 are arranged at an angle of 90 degrees.
And carrying out oblique pulling operation on the membrane layer to form an inclined membrane layer. The concrete diagonal pulling operation is as follows: providing a raw material roller 10, winding the vertical film layer on the surface of the raw material roller 10 to form a raw material roller, opening the raw material roller, fixing one end of the vertical film layer on a winding roller 11, adjusting the relative positions of the raw material roller and the winding roller 11 to enable the raw material roller and the winding roller 11 to intersect in the axial direction, and simultaneously winding the winding roller 11 to form the inclined film layer roll. Since three laminated film layers are prepared in this embodiment, three material rolls 10 and one wind-up roll 11 are provided to operate. In this embodiment, an included angle between one of the material rollers 10 and the wind-up roller 11 is set to 50 °, an included angle between the other of the material rollers 10 and the wind-up roller 11 is set to 55 °, and the remaining one of the material rollers 10 and the wind-up roller 11 are arranged in parallel. Further, the film layer drawn out by the raw material roller 10 parallel to the wind-up roller 11 is a vertical film layer, and is used as the middle layer of the three film layers. Of course, in other embodiments, this angle may be selected according to different requirements, and preferably ranges between 45 ° and 60 °. In order to adjust the inclination angle of the inclined film layer, besides one way of adjusting the angle between the material roll 10 and the wind-up roll 11, in other embodiments, the adjustment can be performed by adjusting the position where the end of the vertical film layer pulling-out material roll is fixed on the wind-up roll 11, or by using a mixture of the two ways.
And simultaneously rolling, performing roll lamination on the laminated film layers by using a hot press roller, and setting the temperature of the hot press roller between 60 ℃ and 140 ℃, preferably 140 ℃. In a specific arrangement, the hot-pressing roller may be a bonding inclined film roll, or may be a roller between a raw material roll and an inclined film roll.
In the present embodiment, the membrane layer provided in step S1 has hollow fiber membrane filaments 5 constituting the membrane layer having an outer diameter of 0.4mm and an inner diameter of 0.2mm, and the pitch of the hollow fiber membrane filaments 5 within the membrane layer is set to 0.6 mm. And the surface of the hollow fiber membrane yarn 5 is provided with a fixing groove for fixing the braided wire 7, the depth of the fixing groove is set to be 100 μm, and the width is set to be 90 μm. Further, the inner side of the hollow fiber membrane yarn 5 is set as a dense layer, the outer layer is a loose layer, the thickness of the loose layer is set as 70 μm, the thickness of the dense layer is set as 1 μm, and the oxygen mass transfer efficiency of the hollow fiber membrane yarn 5 is 395L/(min m.m)2Bar). Further, in the present embodiment, the film layers are woven by the N66 knitting yarn 7, and the specification thereof is selected to be 100F 40D.
It should be noted that, the vertical membrane layer is obliquely pulled, two different modes are disclosed in the application, and the two different modes can be used by a user to prepare the membrane layer with the same size and shape, and relevant performance parameters are not different.
In the present application, as shown in fig. 1, there is further provided an oxygenation assembly comprising a housing disposed in a cylindrical shape, and an oxygenation membrane wound within the housing. The top of casing has been seted up air inlet 1, and air inlet 1 and hollow fiber membrane silk 5 well kenozooecium UNICOM, and gas gets into oxygenation subassembly from air inlet 1, and inside hollow fiber membrane silk 5 was passed from hollow fiber membrane silk 5 one end of hollow fiber membrane silk 5, the other end of hollow fiber membrane silk 5 discharges again to through setting up the oxygenation subassembly of 2 exhalations in the gas outlet of oxygenation subassembly lateral wall, air inlet 1 promptly, hollow fiber membrane silk 5 is inside, the gas vent constitutes the air flue. The hollow fiber membrane web prepared by the invention is wound and then integrally placed in an oxygenation assembly in a columnar form to realize the structure. As shown in fig. 12, which is a plan view (one layer is taken for illustration) of the double-layer laminated oxygen-containing film after winding, in the schematic view, the inclination directions of the double-layer film layers are opposite, and in other embodiments, the inclination directions may be the same and different; or may be a three-layer film or a multi-layer film. As can be seen from fig. 12, the blood flow channel formed outside the hollow fiber membrane filament 5 is quite different from the blood flow channel formed in the prior art (fig. 11), and in the present embodiment, an inclined and simultaneously rotating blood flow channel is formed, which can increase the turbulence effect of the blood flowing inside the blood flow channel, and can ensure that the blood near the center of the blood flow channel can better contact the outer wall of the hollow fiber membrane filament 5, and the blood does not flow out of the flow channel through gas exchange, and can ensure that the part of the blood does not directly flow out of the oxygenation membrane, thus improving the gas exchange efficiency of the blood in the flow channel as a whole.
Meanwhile, a liquid inlet 3 is formed in the side wall of the oxygenation assembly, a liquid outlet 4 is formed in the bottom of the oxygenation assembly, blood flowing into the liquid inlet 3 flows through a cavity formed between the outside of the hollow fiber membrane wire 5 and the shell, and then flows out of the bottom of the oxygenation assembly, namely the liquid inlet 3, the liquid outlet 4 and the cavity form a flow channel. And furthermore, the hollow fiber membrane filaments 5 are provided with sealing elements 6 for sealing between the hollow fiber membrane filaments 5 and between the hollow fiber membrane filaments 5 and the shell at positions close to the two ends, wherein the sealing elements 6 can be glue layers, namely formed by curing glue. Further, in the oxygenation assembly, the air inlet 1 and the air outlet 2 are arranged opposite to the openings at the two ends of the hollow fiber membrane filaments 5.
The method includes the steps of preparing different numbers of laminated film layers based on the methods of the fourth embodiment and the fifth embodiment, controlling relative angles in the process steps to realize the inclination angle of the inclined film layers, and manufacturing experimental samples. And winding the prepared laminated film layer to prepare the oxygenation assembly shown in figure 1, carrying out related performance tests, and recording the test results.
In table one, all samples are PMP oxygen membranes with double-layer membrane layers, each hollow fiber membrane 5 with an inner diameter of 0.2mm and an outer diameter of 0.4mm is selected, a PP woven wire 7 of 10F10D is selected, hollow fiber membrane layers with a space of 0.5mm between membrane wires are woven, the depth of a fixing groove is 10 μm, the width of the fixing groove is 90 μm, the thickness of a compact layer of a single hollow fiber membrane wire 5 is set to be 1 μm, and the thickness of a loose layer is set to be 90 μm. The difference is that the inclination angle of each layer of the double-layered film layer is different, and the inclination angle formed by the hollow fiber membrane filaments 5 between the film layers is different. The film layer inclination angle mentioned in table one means that an included angle formed between the hollow fiber film wire 5 and the horizontal direction is 45-60 degrees when the film layer is laid in the horizontal direction, namely, the included angle on the other side of the hollow fiber film wire 5 is 120-135 degrees, and in all tables in the application, the reverse direction means that the inclination angle of the second film layer is opposite to the inclination direction of the first film layer. In the present application, the included angle degrees are all the included angle degrees of the hollow fiber membrane filaments 5 and the right side in the horizontal direction.
Table one:
Figure BDA0002636847630000201
Figure BDA0002636847630000211
flow 1 in table one, the specific test setup is shown in fig. 6: rolling a sample of which the membrane area is 0.1 square meter into a membrane column, placing the membrane column in a test tube 8, wherein the outer surface of the membrane column is abutted against the inner surface of the test tube 8, one end of the test tube 8 is sealed, the other end is open, and an air outlet is formed in one side wall of the test tube 8. During testing, 1 kilogram of air pressure is applied to the opening end of the testing tube 8, oxygen is introduced into the testing tube, air flow detection is carried out on the air outlet of the testing tube 8, and relevant data are recorded, wherein the larger the flow 1 is, the higher the mass transfer efficiency of the gas is, and the more easily the gas passes through the side wall of the membrane wire.
In table one, flow 2, the specific test apparatus is shown in fig. 7 as: at 25 ℃, a sample with the membrane area of 0.1 square meter is coiled into a membrane column and is placed in a test tube 8, the outer surface of the membrane column is abutted against the inner surface of the test tube 8, and openings are arranged at two ends of the test tube 8. During the test, 1 kilogram of atmospheric pressure is applyed to the one end of test tube 8 now, lets in oxygen to its inside, carries out gas flow monitoring and records relevant data at the other end of test tube 8, and flow 2 is the less, and then it is higher to show oxygen disorder degree when passing through hollow fiber membrane silk 5 insidely.
Flow 3 in table one, the specific test setup is shown in fig. 1: the method comprises the steps of winding an oxygenation membrane with the membrane area of 0.1 square meter and different inclination angles to prepare an oxygenator, introducing bovine blood into the oxygenator at the temperature of 37 ℃, and detecting the bovine blood flow of a liquid outlet 4 of the oxygenator under the condition that the ratio of the introduced gas flow to the introduced bovine blood flow is 1: 1.
In table two, all samples are PMP oxidation membranes with double membrane layers, each hollow fiber membrane filament 5 with an inner diameter of 0.28mm and an outer diameter of 0.38mm is selected, a PP material braided wire 7 of 50F25D is selected, and the hollow fiber membrane layers with a membrane filament spacing of 0.55mm are braided, the thickness of the dense layer of each hollow fiber membrane filament 5 is set to be 0.1 μm, and the thickness of the loose layer is set to be 99 μm. The difference is that the inclination angle of each layer of the double-layered film layer is different, and the inclination angle formed by the hollow fiber membrane filaments 5 between the film layers is different.
Table two:
Figure BDA0002636847630000221
in table two, the test method of the related performance parameters is the same as that in table one.
In the third table, all samples are PMP oxygen membranes with double-layer membrane layers, hollow fiber membrane filaments 5 with an inner diameter of 0.2mm and an outer diameter of 0.3mm are selected, PP woven wires 7 of 100F40D are selected and woven into hollow fiber membrane layers with a space of 0.6mm between membrane filaments, the depth of the fixing groove is 30 μm, the width is 95 μm, the thickness of the compact layer of a single hollow fiber membrane filament 5 is set to be 2.5 μm, and the thickness of the loose layer is set to be 65 μm. The difference is that the inclination angle of each layer of the double-layered film layer is different, and the inclination angle formed by the hollow fiber membrane filaments 5 between the film layers is different.
Table three:
Figure BDA0002636847630000231
in table three, the test mode of the related performance parameters is the same as that in table one.
In table four, all samples are PMP oxygen membranes with three membrane layers, each hollow fiber membrane 5 with an inner diameter of 0.2mm and an outer diameter of 0.3mm is selected, a PET braided wire 7 of 10F10D is selected, hollow fiber membrane layers with a space of 0.7mm between membrane wires are braided, the depth of the fixing groove is 50 μm, the width is 100 μm, the thickness of the compact layer of a single hollow fiber membrane wire 5 is set to be 1.5 μm, and the thickness of the loose layer is set to be 55 μm. In the three-layer film layer oxygen-containing film, the second film layer in the middle layer is a vertical film layer. The difference is the difference in the inclination angle of the first and second film layers and the difference in the inclination angle formed by the hollow fiber membrane filaments 5 between the first and second film layers.
Table four:
Figure BDA0002636847630000241
in table four, the test method of the related performance parameters is the same as that in table one.
In table five, all samples are PMP oxygen membranes with three membrane layers, each hollow fiber membrane 5 with an inner diameter of 0.2mm and an outer diameter of 0.4mm is selected, a PET braided wire 7 of 50F25D is selected, hollow fiber membrane layers with a space of 0.75mm between membrane wires are braided, the depth of the fixing groove is 70 μm, the width of the fixing groove is 105 μm, the thickness of the compact layer of a single hollow fiber membrane wire 5 is set to be 1.2 μm, and the thickness of the loose layer is set to be 65 μm. In the three-layer film layer oxygen-containing film, the second film layer in the middle layer is a vertical film layer. The difference is the difference in the inclination angle of the first and second film layers and the difference in the inclination angle formed by the hollow fiber membrane filaments 5 between the first and second film layers.
Table five:
Figure BDA0002636847630000251
in table five, the test mode of the relevant performance parameters is the same as in table one.
In table six, all samples are PMP oxidation membranes with three membrane layers, each hollow fiber membrane 5 with an inner diameter of 0.28mm and an outer diameter of 0.38mm is selected, a PET braided wire 7 of 50F25D is selected, hollow fiber membrane layers with a space of 0.6mm between membrane wires are braided, the depth of the fixing groove is 100 μm, the width is 110 μm, the thickness of the dense layer of a single hollow fiber membrane wire 5 is set to be 2.5 μm, and the thickness of the loose layer is set to be 75 μm. In the three-layer film layer oxygen-containing film, the second film layer in the middle layer is a vertical film layer. The difference is the difference in the inclination angle of the first and second film layers and the difference in the inclination angle formed by the hollow fiber membrane filaments 5 between the first and second film layers.
Table six:
Figure BDA0002636847630000261
in table six, the test mode of the relevant performance parameters is the same as in table one.
By observing tables one to six above, it can be found that: in any kind of the oxygen-containing membrane, under the condition that the size of the oxygen-containing membrane is fixed, the inclination angle of the single-layer membrane net has little influence on the turbulence effect, but the larger the inclination angle of the membrane net is, the deeper the depth and the wider the width of the fixing groove are, the larger the contact area between the braided wire 7 and the hollow fiber membrane wire 5 is, the friction force is increased, the stronger the strength of the whole membrane net is, and the membrane net is not easy to scatter. The larger the included angle between the hollow fiber membrane filaments 5 in the adjacent membrane layers is, the higher the mass transfer efficiency is, the better the turbulence effect is.
While the preferred embodiments of the present invention have been illustrated and described in detail, it should be understood that various changes and modifications of the invention can be effected therein by those skilled in the art after reading the above teachings of the invention. Such equivalents are intended to fall within the scope of the claims appended hereto.

Claims (33)

1. An oxygen-containing membrane comprises a membrane layer consisting of a plurality of hollow fiber membrane filaments, and is characterized in that: the membrane layer at least comprises two layers, laminated membrane layers are formed by laminating different membrane layers, and any one hollow fiber membrane filament in the membrane layers is partially overlapped with at least one hollow fiber membrane filament in the adjacent membrane layers in the projection of the hollow fiber membrane filament in the laminating direction.
2. The membrane of claim 1, wherein said membrane layer comprises an inclined membrane layer, wherein the edge connecting lines of all hollow fiber membrane filaments at the same end in said inclined membrane layer are straight lines, and at least one section of said hollow fiber membrane filaments or the extension line thereof is disposed at an acute angle with respect to said straight lines.
3. The oxygen-containing membrane of claim 2 wherein said membrane layer is formed by linear hollow fiber membrane filaments.
4. The membrane of claim 3, wherein said hollow fiber membrane filaments are arranged at an angle of 45 ° to 90 ° with respect to a line connecting the edges of the same ends.
5. The membrane of claim 4, wherein said laminated membrane layer is formed by laminating two inclined membrane layers, and the included angle between the hollow fiber membrane filaments in said two inclined membrane layers is set between 5 ° and 90 °.
6. The membrane of claim 2, further comprising a vertical membrane layer, wherein the hollow fiber membrane filaments are connected to a straight line at the same end of the vertical membrane layer, and the hollow fiber membrane filaments are linear, and the hollow fiber membrane filaments are disposed at a right angle to the straight line.
7. The membrane of claim 6, wherein said laminated membrane layer is formed by laminating three membrane layers, wherein said middle layer is a vertical membrane layer, and said two sides are inclined membrane layers, and the angle between the hollow fiber membrane filaments in adjacent membrane layers is between 5 ° and 90 °.
8. An oxygen-containing membrane according to claim 5 or 7, wherein bonding points are provided between different membrane layers in said stack of membrane layers.
9. The membrane according to claim 2 or 6, wherein said hollow fiber membrane filaments are fixed by weaving with braided wires.
10. The membrane of claim 9, wherein fixing grooves are formed at the weaving fixing positions of the hollow fiber membrane filaments and the braided wires.
11. The membrane of claim 10, wherein the depth of said fixing grooves is set to be 10 μm to 100 μm and the width of said fixing grooves is set to be 90 μm to 110 μm.
12. The membrane of claim 11, wherein the depth of said securing grooves increases as the angle between the filaments of the hollow fiber membrane and the braided wire decreases.
13. The membrane of claim 1, wherein said hollow fiber membrane filaments have an outer diameter of between 0.3mm and 0.4mm and an inner diameter of between 0.2mm and 0.28 mm.
14. The oxygen-containing membrane of claim 13 wherein the spacing between the filaments of the hollow fiber membrane is set between 0.5mm and 0.75 mm.
15. The membrane of claim 13, wherein said hollow fiber membrane filaments comprise a loose layer on the inside and a dense layer on the outside.
16. The membrane of claim 15, wherein the dense layer is between 0.1 μ ι η and 3 μ ι η thick and the loose layer is between 47 μ ι η and 99 μ ι η thick.
17. The oxygen-containing membrane according to claim 13, wherein the hollow fiber membrane filaments have an oxygen mass transfer efficiency of 15 to 400L/(min)·m2MPa).
18. The oxygen-containing film as claimed in claim 9, wherein the braided wire includes but is not limited to PP, PET, N6, N66 and their blends, with gauge selected between 10F-100F, 10D-60D.
19. A method for producing the oxygen-containing membrane according to claim 1, comprising the steps of:
s1: providing a film layer consisting of at least two layers of hollow fiber film filaments;
s2: laminating the film layers prepared in the step S1 to form a laminated film layer, wherein in the laminated film layer, any one hollow fiber film filament in any one film layer is partially overlapped with at least one hollow fiber film filament in an adjacent film layer in the projection of the hollow fiber film filament in the laminating direction;
s3: shaping;
s4: and (4) winding, namely winding the laminated film layer.
20. The method of claim 19, wherein the membrane layer provided in step S1 is woven between woven threads and hollow fiber membrane filaments.
21. The method of claim 20, wherein the membrane layer woven in the step of S1 is a vertical membrane layer in which the filaments of the hollow fiber membrane and the woven thread are perpendicular to each other.
22. The method for preparing an oxygen-containing membrane as claimed in claim 21, further comprising a step of diagonal pulling the vertical membrane layer into an inclined membrane layer between the step of S1 and the step of S2.
23. The method for producing an oxygenated membrane of claim 22, wherein the pulling of the strand is performed by,
taking a rectangular vertical film layer, opening and paving, fixing opposite sides of the vertical film layer by using a fixing device, and applying acting force to enable an inclined angle to be generated between hollow fiber film filaments and braided wires in the film layer to form an inclined film layer roll;
alternatively, the first and second electrodes may be,
winding the vertical film layer on the surface of the raw material roll to form a raw material roll, opening the raw material roll, fixing one end of the vertical film layer on a winding roll, adjusting the relative positions of the raw material roll and the winding roll to enable the raw material roll and the winding roll to be crossed in the axis direction, unwinding the raw material roll and winding the winding roll to form an inclined film layer.
24. The method for producing an oxygen-containing membrane according to claim 23, wherein said step S2 specifically comprises,
s2-1: opening and paving a first rectangular inclined film layer;
s2-2: opening and paving a second rectangular inclined film layer;
s2-3: laminating a first film layer and a second film layer to form a double-layer film layer, wherein the first inclined film web and the second inclined film web have different inclination angles;
alternatively, the first and second electrodes may be,
s2-1: opening and paving a first rectangular vertical film layer;
s2-2: opening and paving a second rectangular inclined film layer;
s2-3: laminating the first film layer and the second film layer to form a double-layer film layer;
alternatively, the first and second electrodes may be,
s2-1: taking a rectangular vertical film layer, opening and paving;
s2-2: opening and paving another two rectangular inclined film layers;
s2-3: and respectively placing the inclined film layers on two sides of the vertical film layer for laminating to form three film layers.
25. The method for producing an oxygen-containing membrane according to claim 24, wherein said step of S2 further comprises,
s2-4: and (3) carrying out air-blowing heat seal on the double-layer film layer or the three-layer film layer by using a hot air gun.
26. The method for preparing an oxygen-containing membrane according to claim 25, wherein the temperature of the hot air gun in the step S2-4 is set to be between 60 ℃ and 140 ℃.
27. The method for producing an oxygen-containing membrane according to claim 23, wherein said step S2 specifically comprises,
s 2-1: providing a first raw material roll, a second raw material roll and a winding roll, wherein the axis of the first raw material roll and the axis of the winding roll are arranged in parallel, and the axis of the second raw material roll and the axis of the winding roll are intersected in a different plane;
s 2-2: unwinding the film layers on the first raw material roll and the second raw material roll, and flatly laying and laminating the end parts of the film layers and fixing the end parts on the surface of a winding roller;
s 2-3: when the first raw material roll and the second raw material roll are unreeled, the wind-up roll is used for reeling up;
alternatively, the first and second electrodes may be,
s 2-1: providing a first raw material roll, a second raw material roll and a winding roll, wherein the axis of the first raw material roll and the axis of the winding roll are intersected in a non-coplanar manner, and the axis of the second raw material roll and the axis of the winding roll are intersected in a non-coplanar manner;
s 2-2: unwinding the film layers on the first raw material roll and the second raw material roll, and flatly laying and laminating the end parts of the film layers and fixing the end parts on the surface of a winding roller;
s 2-3: when the first raw material roll and the second raw material roll are unreeled, the wind-up roll is used for reeling up;
alternatively, the first and second electrodes may be,
s 2-1: providing a first raw material roll, a second raw material roll, a third raw material roll and a winding roll, wherein the axis of the first raw material roll is intersected with the axis of the winding roll in a different plane, the axis of the second raw material roll is intersected with the axis of the winding roll in a different plane, and the axis of the third raw material roll is arranged in parallel with the axis of the winding roll;
s 2-2: unwinding the film layers on the first raw material roll, the second raw material roll and the third raw material roll, and flatly laying and laminating the end parts of the film layers and fixing the end parts on the surface of a winding roll, wherein the unwound film layer on the third raw material roll is arranged on the middle layer;
s 2-3: and when the first material roll, the second material roll and the third material roll are unreeled, the wind-up roll is reeled.
28. The method for producing an oxygen-containing membrane as claimed in claim 27, wherein said step S2 further comprises S2-4: and when the raw material roll is unreeled and the wind-up roll is reeled, the hot-pressing roll is used for carrying out rolling compounding on the laminated film layers.
29. The method for preparing an oxygen-containing membrane according to claim 28, wherein the temperature of the hot pressing roll in the s2-4 step is set to be between 60 ℃ and 140 ℃.
30. The method for producing an oxygen-containing film as set forth in claim 27, wherein the axis of the first raw material roll and the axis of the second raw material roll in the step s2-2 are intersected in a non-planar manner.
31. An oxygenation module using the oxygenation membrane prepared in claim 19, comprising a housing, and an oxygenation membrane wound in the housing, wherein the housing is provided with a liquid inlet, a liquid outlet, an air inlet and an air outlet, the air inlet, the air outlet and the interior of the hollow fiber membrane filaments of the oxygenation membrane form an air passage, a cavity is formed between the outer side wall of the hollow fiber membrane filaments and the housing, the liquid inlet, the cavity and the liquid outlet form a flow passage, the single hollow fiber membrane filament is spirally arranged around the winding axis of the oxygenation membrane, and the spiral inclination angles of the hollow fiber membrane filaments in the adjacent membrane layers in the oxygenation membrane are different.
32. The oxygenation assembly of claim 31, wherein the hollow fiber membrane filaments are provided with a seal proximate each end to seal between the hollow fiber membrane filaments and the hollow fiber membrane filaments, and between the hollow fiber membrane filaments and the housing.
33. An oxygenation assembly as claimed in claim 31 or claim 32, wherein the gas inlet is open opposite one end of the hollow fibre membrane filaments and the gas outlet is open opposite the other end of the hollow fibre membrane filaments.
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