CN114733371A

CN114733371A - Oxygenation membrane net and oxygenation subassembly

Info

Publication number: CN114733371A
Application number: CN202110015347.3A
Authority: CN
Inventors: 贾建东; 陈梦泽; 蔡良; 张虞旭驹; 潘哲
Original assignee: Hangzhou Feier New Material Co ltd
Current assignee: Hangzhou Feier New Material Co ltd
Priority date: 2021-01-07
Filing date: 2021-01-07
Publication date: 2022-07-12
Anticipated expiration: 2041-01-07
Also published as: CN114733371B

Abstract

The invention relates to an oxygenated membrane net, which comprises a plurality of hollow fiber membrane filaments which are arranged in the same direction, the positions of the hollow fiber membrane filaments are relatively fixed, the outer diameter of the hollow fiber membrane filaments is set to d, the distance between the adjacent hollow fiber membrane filaments is set to L1, a hollow columnar efficient exchange area concentric with the cross section circle of the hollow fiber membrane filaments is formed outside the hollow fiber membrane filaments, the oxygen mass transfer rate in the efficient exchange area is at least 50mL/(min square meter) @400mL/min blood flow rate @400mL/min oxygen flow rate, a gas separation factor alpha (CO2/O2) is arranged between 1 and 4, the width of the minimum position of the efficient exchange area is set to w, and L1 is not more than 2(0.5d + w). The invention aims to provide an oxygenation membrane net with high gas exchange efficiency and an oxygenation assembly with high gas exchange efficiency.

Description

Oxygenation membrane net and oxygenation subassembly

Technical Field

The invention relates to a gas exchange membrane, in particular to an oxygenation membrane net and an oxygenation assembly.

Background

Extracorporeal Membrane Oxygenation (ECMO) is mainly used to provide continuous Extracorporeal respiration and circulation to patients with severe cardiopulmonary failure to sustain the life of the patient. The ECMO mainly comprises an intravascular cannula, a connecting pipe, a power pump (artificial heart), an oxygenator (artificial lung), an oxygen supply pipe, a monitoring system and the like. The core of which is an oxygenator (artificial lung) to perform oxygen-carbon dioxide exchange and a powered pump (artificial heart) to provide blood flow power.

The working principle is as follows: the venous blood in the body of the patient is led to the oxygenator, the venous blood exchanges oxygen-carbon dioxide in the oxygenator, after the blood flows out of the oxygenator, the oxygen content in the blood is increased, the carbon dioxide content is reduced, the effect of changing the venous blood into arterial blood in vitro is realized, damaged lungs of the patient are replaced, and the life of the patient is maintained. The core component in the oxygenator is the oxygenation membrane, and in order to improve the oxygenation effect and efficiency, the oxygenator and the oxygenation membrane need to be arranged in a relevant way.

In the prior art, oxygenators are divided into a silica gel membrane type and a hollow fiber type, and for the case that the hollow fiber membrane is used as an oxygenation membrane, the main component of the oxygenation membrane which performs oxygen-carbon dioxide exchange is the hollow fiber membrane. Get single hollow fiber membrane silk and carry out the analysis, in the in-process of work, continuously lead to air or oxygen or other relevant gas in the inside hollow tube of hollow fiber membrane silk, blood surrounds the flow outside the hollow fiber membrane silk, at the in-process that flows, because the inside oxygen content of hollow fiber membrane silk is high, and carbon dioxide content in the blood is low, consequently oxygen can pass the pipe wall diffusion to blood from hollow fiber membrane silk inside, carbon dioxide can pass the pipe wall diffusion to the inside hollow tube of hollow fiber membrane silk in the blood to realize gas exchange's function. In the oxygenator, an oxygenation membrane consisting of a plurality of hollow fiber membrane filaments is included, and blood flows around the hollow fiber membrane filaments. Conventional oxygen-containing membranes are set up as follows: weaving a plurality of hollow fiber membrane filaments into a single-layer net structure through braided wires, wherein the hollow fiber membrane filaments and the braided wires are in a right angle, and then winding the hollow fiber membrane layer of the net structure to enable the hollow fiber membrane layer to be in a column shape integrally, wherein one end of the hollow fiber membrane layer is an air inlet end, and the other end of the hollow fiber membrane layer is an air outlet end, so that the hollow fiber membrane is used. Such a product also has room for optimization of the overall gas exchange efficiency.

Disclosure of Invention

The invention aims to provide an oxygenation membrane net with high gas exchange efficiency and an oxygenation assembly with high gas exchange efficiency.

The applicant conducted an analysis of the prior art, and found that, in the arrangement of the hollow fiber membrane filaments of the prior art as shown in fig. 11, 12 and 13, the blood flow channels formed between the hollow fiber membrane filaments are parallel and uniform, and in fig. 11, the vertical arrows point in the direction of blood flow, and the horizontal arrows point in the direction of diffusion of carbon dioxide in blood (the direction of diffusion of oxygen is opposite thereto). In fig. 11 to 12, the blood in the hollow tubular space surrounded by the dotted line outside the hollow fiber membrane filaments is closer to the hollow fiber membrane filaments (i.e., the blood in the B region shown in the figure, which may be referred to as a high-efficiency exchange region), so that the carbon dioxide in the B region is more easily diffused into the hollow fiber membrane filaments to exchange gas with oxygen; between the hollow fiber membrane filaments and the adjacent hollow fiber membrane filaments, there is a low efficiency exchange zone (i.e., zone a shown in the figure) relatively far from the hollow fiber membrane filaments, in which carbon dioxide in blood needs to diffuse laterally into zone B and then diffuse from zone B into the hollow fiber membrane filaments to exchange gas with oxygen. When the blood flow rate is high, carbon dioxide in the area A flows out of the oxygenator along with the blood without having to exchange gas, so that the overall gas exchange efficiency is low. Further, in the analysis of the B region, since a certain time is required for the lateral diffusion of carbon dioxide in blood, the radius of the high-efficiency exchange region gradually decreases along the direction of blood flow (i.e. the outside of the hollow fiber membrane filament includes two dotted concentric circular spaces with different sizes as viewed from the end face of the hollow fiber membrane filament in fig. 12 and 13), and the blood at the downstream side is more difficult to exchange gas, thereby further reducing the overall gas exchange efficiency.

In order to solve the problems, the invention adopts the following technical scheme: an oxygenation membrane net comprises a plurality of hollow fiber membrane filaments which are arranged in the same direction, the positions of the hollow fiber membrane filaments are relatively fixed, the outer diameter of each hollow fiber membrane filament is d, the distance between every two adjacent hollow fiber membrane filaments is L1, a hollow columnar efficient exchange area concentric with the cross section circle of each hollow fiber membrane filament is formed outside each hollow fiber membrane filament, the oxygen mass transfer rate in the efficient exchange area is at least 50mL/(min × square meter) @400mL/min blood flow rate @400mL/min oxygen flow rate, a gas separation factor alpha (CO2/O2) is arranged between 1 and 4, the width of the minimum position of the efficient exchange area is w, and L1 is not more than 2(0.5d + w).

By adopting the technical scheme, the maximum distance between the hollow fiber membrane filaments and the hollow fiber membrane filaments is not more than twice of the radius of the minimum efficient exchange area (the radius of the efficient exchange area is the half length of the outer diameter of the hollow fiber membrane filaments plus the width of the minimum position of the efficient exchange area), the minimum efficient exchange area between the adjacent hollow fiber membrane filaments is at least tangent, even partially overlapped, the space of the low-efficiency exchange area is greatly reduced, the blood is greatly positioned in the range of the high-efficiency exchange area when passing through the oxygenation membrane net, and the efficient gas exchange rate of the oxygenation membrane net is ensured. It should be noted here that both the efficient and inefficient switching zones are artificially divided by different effects. Taking a single hollow fiber membrane filament for analysis, dividing the hollow fiber membrane filament into a plurality of concentric circles around the center, forming a gas exchange area between each concentric circle and the outer surface of the hollow fiber membrane filament, wherein the gas exchange rate in the smallest concentric circle area close to one layer of the surface of the hollow fiber membrane filament is the highest, and the gas exchange rate is lower as the diameter is increased and the gas exchange rate is farther away from the area of the hollow fiber membrane filament; therefore, the gas exchange rates in the boundary of the areas surrounded by the different concentric circles and the outer surfaces of the hollow fiber membrane filaments are different, when the oxygen mass transfer rate in a certain boundary is at least 50mL/(min square meter) @400mL/min blood flow rate @400mL/min oxygen flow rate, that is, the position is considered as the boundary of the high-efficiency exchange area, the gas separation factor alpha (CO2/O2) is set between 1 and 4. The gas separation factor is the ratio of the rate of permeation of carbon dioxide through the hollow fiber membrane to the rate of permeation of oxygen through the hollow fiber membrane. Specifically, one surface of the membrane sample can be subjected to gas to be measured (oxygen, carbon dioxide and anesthetic gas) under the conditions that the temperature is 25 ℃, the pressure is 1bar, and the area of the membrane sample is 0.1 square meter; supplying a gas to be measured into the inner cavity of the hollow fiber membrane; measuring the volume flow rate of the gas passing through the membrane wall of the sample with a flow meter (KOFLOC/4800, Japan); the test was performed 3 times from inside the membrane to outside the membrane and also three times from outside the membrane to inside the membrane, and then an average value was taken, which was the gas permeation rate of the membrane. In order to more intuitively display the advantages of the present solution, a case where L1 is 2(0.5d + w) (i.e., a case where the pitch L1 between the hollow fiber membrane filaments is equal to the radius of the minimum efficient exchange area) is selected, as specifically shown in fig. 6. In fig. 6, the bottom of the hollow fiber membrane yarn is the minimum efficient exchange area, the minimum efficient exchange areas of two adjacent hollow fiber membrane yarns are all set to be tangent, so that the efficient exchange areas at other positions can be overlapped for the adjacent hollow fiber membrane yarns, the space of the low-efficiency exchange area can be greatly reduced, and the overall gas exchange rate is improved to improve the overall gas exchange efficiency. For the determination of the high-efficiency exchange area, a single hollow fiber membrane yarn can be placed in cylindrical containers with different diameters to form an oxygenation assembly of the single membrane yarn, the oxygen mass transfer rate of the oxygenation assembly is detected, when the oxygen mass transfer rate is detected to reach 50mL/(min x square meter) @400mL/min blood flow rate @400mL/min oxygen flow rate, the diameter of the cylindrical container is considered to be the diameter of the high-efficiency exchange area, and the value w is half of the difference value obtained by subtracting the outer diameter of the hollow fiber membrane yarn from the diameter of the high-efficiency exchange area. In order to reduce the individual influence of a single hollow fiber membrane wire and eliminate special conditions, 5-10 hollow fiber membrane wires can be used for testing, and after the maximum value and the minimum value of w are eliminated, the average value of the w is used as the determination of the final w value.

Furthermore, when three adjacent hollow fiber membrane filaments in the plurality of hollow fiber membrane filaments are triangular, the hollow fiber membrane filaments are provided with a plurality of holes

When four adjacent hollow fiber membrane filaments are square, the fiber membrane is made of the following materials

By adopting the technical scheme, the volume of the low-efficiency exchange area can be reduced or even eliminated. The following description is made with reference to fig. 7, 8, 9 and 10, wherein the views are all views of the end face of the oxygenation membrane net, and the structures of three or four adjacent hollow fiber membrane filaments are selected for analysis. As can be seen from fig. 7 and 9, the high efficiency exchange areas of the adjacent hollow fiber membrane filaments do not have an overlapping area at the end positions of the hollow fiber membrane filaments, but a space of a part of the low efficiency exchange area is still present in the middle regardless of the form of three or four hollow fiber membrane filaments, and thus an optimal value for the gas exchange rate is not yet achieved. However, as can be seen from the observation of fig. 8 and 10, the high-efficiency exchange areas of the adjacent hollow fiber membrane filaments have a certain overlap, and no space is left for the low-efficiency exchange areas, so that the arrangement has more excellent gas exchange efficiency.

Further, the mass transfer rate of carbon dioxide in the efficient exchange area is at least 100mL/(min square meter) @400mL/min blood flow rate @400mL/min oxygen flow rate.

By adopting the technical scheme, the range of the outer edge of the high-efficiency exchange area is limited from the perspective of the mass transfer rate of the carbon dioxide, and the high-efficiency exchange area is ensured to have higher mass transfer efficiency.

Further, the length of the hollow fiber membrane filament is set to be L2, and L2 is more than or equal to 145L1 and less than or equal to 380L 1.

Through adopting above-mentioned technical scheme, inject the length of hollow fiber membrane silk, if hollow fiber membrane silk length overlength, then the radius of the minimum high-efficient exchange area of membrane silk terminal position department will be undersize, will make hollow fiber membrane silk terminal part do not exert the gas exchange function that should have relatively, make this section hollow fiber membrane silk wasted. If the hollow fiber membrane filaments are too short in length, the gas exchange efficiency of the integrally formed oxygenation membrane web and oxygenation device is relatively low.

Further, the space L1 between the hollow fiber membrane filaments is set between 0.5mm and 0.75 mm.

Through adopting above-mentioned technical scheme, more quantitatively limited the interval between the hollow fiber membrane silk, be convenient for when the product actual production to the accuse of interval.

Further, at least one of the hollow fiber membrane filaments is partially overlapped with the adjacent hollow fiber membrane filament in the radial projection.

Through adopting above-mentioned technical scheme, can guarantee relative crisscross setting between the hollow fiber membrane silk, hollow fiber membrane silk and hollow fiber membrane silk are not always all parallel arrangement promptly, have partial overlap in its radial projection. The turbulence degree of blood can be increased when the blood flows through the gaps between the hollow fiber membrane filaments, so that the blood flow in the high-efficiency exchange area and the low-efficiency exchange area is more disordered, and the oxygen-carbon dioxide gas exchange is more facilitated.

Furthermore, the hollow fiber membrane filaments are arranged in a linear type, a single-layer plane net is woven among the hollow fiber membrane filaments through braided wires, and the hollow fiber membrane filaments are arranged vertically or obliquely in the radial direction; the single-layer plane net or the multiple-layer plane net is wound to form the oxygenated membrane net.

By adopting the technical scheme, the oxygenation membrane net is more specifically limited to be formed by winding a single-layer vertical or inclined membrane net; or, a double layer vertical or inclined film web is wound. Discloses a simple forming mode of an oxygenation membrane net, and can ensure that hollow fiber membrane filaments in the oxygenation membrane net can be staggered to a certain degree, increase the turbulent flow effect of blood passing during use and improve the whole gas exchange efficiency. Meanwhile, the plane net is limited to be woven by braided wires, so that a certain position relation among different hollow fiber membrane yarns can be ensured, and the whole plane net has certain structural strength.

Further, the hollow fiber membrane filaments are spaced by weaving knots of the weaving thread.

Through adopting above-mentioned technical scheme, the braided wire can produce and weave the knot when weaving into the membrane net with hollow fiber membrane silk, controls the interval between the hollow fiber membrane silk through the size of weaving the knot in actual production process, is convenient for in the actual production to the control of interval.

Furthermore, the distance between adjacent weaving knots on the same hollow fiber membrane yarn is set between 0.1cm and 1 cm.

By adopting the technical scheme, the density of the braided wires is ensured, and when the braided wires are braided into the membrane net, the braided wires are not too dense, and the too dense braided wires can cover more surface areas of the hollow fiber membrane filaments to influence the gas exchange effect; too sparse of braided wire may affect the overall structural strength of the membrane web.

Further, the inclination angle of the hollow fiber membrane filaments is set between 0 and 45 degrees.

Through adopting above-mentioned technical scheme, guaranteed to present certain contained angle in order to increase the turbulent effect of blood between hollow fiber membrane silk and the hollow fiber membrane silk, too big inclination then can influence the mobility of blood, and the blood velocity of flow reduces during, and the pressure drop increases.

Furthermore, when the oxygenation membrane net is a multilayer plane net and is wound, the included angle of the hollow fiber membrane filaments in two adjacent layers of plane nets is set between 5 degrees and 90 degrees.

By adopting the technical scheme, after the multilayer plane net is wound, certain included angles exist among the hollow fiber membrane yarns in different plane nets, the turbulent flow effect of blood in flowing is further increased, and the gas exchange efficiency is enhanced.

Furthermore, a bonding point is arranged between the adjacent plane nets.

By adopting the technical scheme, the arrangement of the bonding points indicates that different film layers are bonded through specific positions, and the bonding points include but are not limited to bonding points formed by heat sealing, adhesion, electrostatic attraction and the like.

Further, the outer diameter of the hollow fiber membrane yarn is set to be 0.3mm-0.4mm, and the inner diameter is set to be 0.2mm-0.28 mm.

By adopting the technical scheme, the number of hollow fiber membrane filaments in the oxygenation membrane and the gas exchange effect of a single membrane filament can be ensured. If the outer diameter of the hollow fiber membrane wire is too large and the inner diameter is too small, the diffusion rate of oxygen and carbon dioxide is very low; if the outer diameter of the hollow fiber membrane filaments is too large and the inner diameter is too large, a large part of air or oxygen in the hollow is wasted; if the outer diameter of the hollow fiber membrane wire is too small and the inner diameter is too large, blood can easily permeate the tube wall of the hollow fiber membrane wire to cause the hollow fiber membrane wire to lose efficacy; if the outer diameter of the hollow fiber membrane wire is too small and the inner diameter is too small, the difficulty of the production process is increased, and the production cost is increased.

Further, the hollow fiber membrane yarn comprises a loose layer positioned on the inner side and a dense layer positioned on the outer side.

Further, the thickness of the dense layer is set to be between 0.1 and 3 microns, and the thickness of the loose layer is set to be between 47 and 99 microns.

By adopting the technical scheme, the compact layer on the outer side of the hollow fiber membrane yarn can ensure that the permeation speed is very low when blood flows through the outside of the hollow fiber membrane yarn, so that the effective service life of the oxygen-containing membrane is prolonged. If the thickness of the compact layer is too large, although the speed of blood permeating the hollow fiber membrane filaments can be reduced, the oxygen-carbon dioxide exchange rate can be influenced; if the thickness of the dense layer is too small, although the oxygen-carbon dioxide exchange rate is fast, the speed of the hollow fiber membrane filaments permeated by blood is also fast, so that the effective service life is low.

Further, the braided wire includes but is not limited to PP, PET, N6, N66 and their blends, and the gauge is selected from 10F-100F, 10D-60D.

Through adopting above-mentioned technical scheme, limited the material, the thickness of braided wire to guarantee to weave the structural strength of whole oxygenized membrane, be difficult to the fracture damage.

The oxygenation assembly comprises a shell and an oxygenation membrane wound in the shell, and is characterized in that the shell is provided with a liquid inlet, a liquid outlet, an air inlet and an air outlet, the air inlet, the air outlet and the interior of a hollow fiber membrane filament of the oxygenation membrane form an air passage, a cavity is formed between the outer side wall of the hollow fiber membrane filament and the shell, the liquid inlet, the cavity and the liquid outlet form a flow passage, a single hollow fiber membrane filament is spirally arranged around the winding axis of the oxygenation membrane, and spiral inclination angles of the hollow fiber membrane filaments in adjacent membrane layers in the oxygenation membrane are different.

Furthermore, the hollow fiber membrane filaments are provided with sealing elements at positions close to the two ends for sealing the space between the hollow fiber membrane filaments and the space between the hollow fiber membrane filaments and the shell.

Furthermore, the air inlet is opposite to an opening at one end of the hollow fiber membrane yarn, and the air outlet is opposite to an opening at the other end of the hollow fiber membrane yarn.

By adopting the technical scheme, the air passage and the flow passage in the oxygenation assembly are relatively isolated, blood flows through the outer surface of the hollow fiber membrane wire in the flow passage, air passes through the hollow fiber membrane wire, and oxygen-carbon dioxide gas exchange occurs at the moment. The air inlet and the air outlet are arranged so that air or oxygen can smoothly enter the hollow fiber membrane filaments.

Compared with the prior art, the oxygenation membrane net and the oxygenation assembly using the oxygenation membrane net have the advantages that: 1. by limiting the space between the hollow fiber membrane filaments, the space volume of the low-efficiency exchange area is reduced, and the space volume of the high-efficiency exchange area is relatively increased to increase the gas exchange efficiency of the oxygenation membrane net and the oxygenation assembly. 2. The relative position and shape between different hollow fiber membrane filaments are limited to ensure that blood has stronger turbulent flow effect when flowing in the hollow fiber membrane filaments so as to ensure that the blood at different positions can be in full contact with the hollow fiber membrane filaments, thereby improving the overall oxygen-carbon dioxide exchange rate. 3. The structural strength between the hollow fiber membrane filaments and the braided wires in the oxygenation membrane net is stronger, relative sliding is not easy to occur between the hollow fiber membrane filaments and the braided wires, and the possibility that the surface structure of the hollow fiber membrane filaments is damaged due to the fact that the braided wires slide on the surfaces of the hollow fiber membrane filaments is reduced. 4. The whole scheme has relatively simple structure and is easy to realize.

Drawings

The invention will be further described with reference to the accompanying drawings in which:

FIG. 1 is a schematic view of the construction of the oxygenation assembly of the present invention;

FIG. 2 is a first schematic view of a planar screen according to the present invention;

FIG. 3 is a second schematic view of a planar net according to the present invention;

FIG. 4 is a first schematic view of a two-layer planar screen according to the present invention;

FIG. 5 is a second schematic view of a two-layer planar net according to the present invention;

FIG. 6 is a schematic structural view of two adjacent hollow fiber membrane filaments according to the present invention;

FIG. 7 is a first schematic structural diagram of four adjacent hollow fiber membrane filaments according to the present invention;

FIG. 8 is a schematic structural diagram II of four adjacent hollow fiber membrane filaments according to the present invention;

FIG. 9 is a first schematic structural diagram of three adjacent hollow fiber membrane filaments according to the present invention;

FIG. 10 is a second schematic structural view of three adjacent hollow fiber membrane filaments according to the present invention;

FIG. 11 is a schematic structural view of a prior art structure between two adjacent hollow fiber membrane filaments;

FIG. 12 is a schematic structural diagram of three adjacent hollow fiber membrane filaments according to the prior art;

fig. 13 is a schematic structural diagram of four adjacent hollow fiber membrane filaments in the prior art.

In the figure: 1. an air inlet; 2. an air outlet; 3. a liquid inlet; 4. a liquid outlet; 5. hollow fiber membrane filaments; 6. a seal member; 7. weaving wires; 8. an oxygenation assembly.

Detailed Description

In order that the above objects, features and advantages of the present invention can be more clearly understood, a more particular description of the invention will be rendered by reference to the appended drawings. It should be noted that the embodiments and features of the embodiments of the present application may be combined with each other without conflict.

In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, however, the present invention may be practiced otherwise than as specifically described herein and, therefore, the scope of the present invention is not limited by the specific embodiments disclosed below.

The first embodiment is as follows:

an oxygenation membrane net comprises a plurality of hollow fiber membrane filaments 5 which are arranged in the same direction. The same direction as used herein means that the hollow fiber membrane filaments 5 are oriented in the same direction, and does not mean that the angles at which the hollow fiber membrane filaments 5 are arranged are all the same. The arrangement includes a plurality of arrangement modes, a plurality of relatively independent single hollow fiber membrane filaments 5 can be stacked, or a plurality of hollow fiber membrane filaments 5 can be woven to form a plane net and then stacked or wound, so that the hollow fiber membrane filaments 5 are arranged in the same direction, and only the hollow fiber membrane filaments 5 are gathered together in a certain direction according to a certain form. In this embodiment, the hollow fiber membrane filaments 5 are first woven into a single-layer plane net by the weaving yarn 7, and then the plane net is wound to form an oxygenated membrane net, wherein the distance between adjacent weaving knots on the same hollow fiber membrane filament 5 in the plane net is 0.1 cm. In the planar net shown in fig. 2, the hollow fiber membrane filaments 5 are arranged obliquely at an angle of 30 °; as in the planar mesh shown in fig. 3. The hollow fiber membrane filaments 5 are arranged in a curve, but other arrangements are also possible. And winding the plane net to form an integral oxygenation membrane net. During the process of weaving the oxygenation membrane net, the weaving wire 7 is selected to be a pp material weaving wire 7, and the specification is selected to be 10F and 10D.

For a single hollow fiber membrane yarn 5, the material is PMP material, the outer diameter is set to be 0.3mm, the inner diameter is set to be 0.2mm, the length is 20mm, a plurality of fixing grooves for containing and fixing the braided wires 7 are arranged on the surface of the hollow fiber membrane yarn, the depth of each fixing groove is set to be 10 microns, the width of each fixing groove is set to be 90 microns, the hollow fiber membrane yarn 5 comprises a loose layer and a compact layer, the loose layer is located on the inner side, the compact layer is located on the outer side, the thickness of the loose layer is set to be 47 microns, and the thickness of the compact layer is set to be 0.1 microns.

In the case of the oxygenation membrane web, when viewed from the end face, it can be seen that, when viewed from the end face, each hollow fiber membrane filament 5 is distributed in a circular shape, and the specific distribution may be approximately in a matrix distribution (where the matrix distribution refers to approximately in such a distribution, due to the accuracy problem of the planar web during the winding and filling processes, a certain error may be generated, so that a very accurate and perfect matrix or regular distribution may not be presented, but it is considered that at least more than 80% of the hollow fiber membrane filaments 5 are arranged in a manner as described above). In the present embodiment, the hollow fiber membrane yarn 5 can be divided into the smallest square units when viewed from the end surface, as shown in fig. 7. Of course, it may be distributed in a form other than a matrix, for example, some of the hollow fiber membrane filaments 5 may have a slightly larger and slightly smaller space therebetween. In fig. 7, the hollow fiber membrane filaments 5 are cut into the smallest square units according to the shape of the end faces, and the interval L1 between the hollow fiber membrane filaments 5 is just equal to 2(0.5d + w). More specifically, L1 is 0.5mm and w is 0.1 mm.

The second embodiment:

an oxygenation membrane net comprises a plurality of hollow fiber membrane filaments 5 which are arranged in the same direction. The same direction as used herein means that the different hollow fiber membrane filaments 5 are oriented in the same direction, and does not mean that the angles of the hollow fiber membrane filaments 5 are all set to be the same. The arrangement includes a plurality of arrangement modes, a plurality of relatively independent single hollow fiber membrane filaments 5 can be stacked, or a plurality of hollow fiber membrane filaments 5 can be woven to form a plane net and then stacked or wound, so that the hollow fiber membrane filaments 5 are arranged in the same direction, and only the hollow fiber membrane filaments 5 are gathered together in a certain direction according to a certain form. In this embodiment, the hollow fiber membrane filaments 5 are first woven into a single-layer plane net by the weaving yarn 7, and then the plane net is wound to form an oxygenated membrane net, wherein the distance between adjacent weaving knots on the same hollow fiber membrane filament 5 in the plane net is 0.2 cm. In the planar net shown in fig. 2, the hollow fiber membrane filaments 5 are arranged obliquely at an angle of 5 ° (the angle at which the membrane filaments are inclined in the figure is only for the purpose of indicating the inclination, and does not represent the actual inclination angle, i.e., the inclination angle measured in the figure); as in the planar mesh shown in fig. 3. The hollow fiber membrane filaments 5 are arranged in a curve, but other arrangements are also possible. And winding the plane net to form an integral oxygenation membrane net. During the process of knitting the oxygenation membrane net, the knitting yarn 7 is selected to be pp material knitting yarn 7, and the specification is selected to be 21F and 16D.

For a single hollow fiber membrane yarn 5, the material is PMP material, the outer diameter is set to 0.31mm, the inner diameter is set to 0.21mm, the length is 15mm, a plurality of fixing grooves for accommodating and fixing the braided wire 7 are arranged on the surface of the hollow fiber membrane yarn, the depth of the fixing grooves is set to 20 μm, the width is set to 92 μm, the hollow fiber membrane yarn 5 comprises a loose layer positioned on the inner side and a compact layer positioned on the outer side, the thickness of the loose layer is set to 53 μm, and the thickness of the compact layer is set to 0.4 μm.

In the case of the oxygenation membrane net, when viewed from the end face, it can be seen that, when viewed from the end face, each hollow fiber membrane filament 5 is distributed in a circle shape, and the specific distribution may be approximately in a matrix distribution (where the matrix distribution is approximately in the distribution, due to the accuracy problem of the planar net during the winding and filling processes, a certain error may be generated, so that a very accurate and perfect matrix or regular distribution may not be presented, but it is considered that at least more than 80% of the hollow fiber membrane filaments 5 are arranged in accordance with the above arrangement). In the present embodiment, the hollow fiber membrane yarn 5 can be divided into the smallest square units when viewed from the end surface, as shown in fig. 8. Of course, the hollow fiber membrane filaments 5 may be distributed in a form other than a matrix, for example, the spacing between the hollow fiber membrane filaments may be slightly larger or slightly smaller. In FIG. 8, the hollow fiber membrane filaments 5 are cut into the smallest square units according to the end surface shapes thereof, and the interval L1 between the hollow fiber membrane filaments 5 is just equal to

More specifically, L1 is 0.53mm and w is 0.22 mm.

Example three:

an oxygenation membrane net comprises a plurality of hollow fiber membrane filaments 5 which are arranged in the same direction. The same direction as used herein means that the hollow fiber membrane filaments 5 are oriented in the same direction, and does not mean that the angles at which the hollow fiber membrane filaments 5 are arranged are all the same. The arrangement includes a plurality of arrangement modes, a plurality of relatively independent single hollow fiber membrane filaments 5 can be stacked, or a plurality of hollow fiber membrane filaments 5 can be woven to form a plane net and then stacked or wound, so that the hollow fiber membrane filaments 5 are arranged in the same direction, and only the hollow fiber membrane filaments 5 are gathered together in a certain direction according to a certain form. In this embodiment, the hollow fiber membrane filaments 5 are first woven into a single-layer plane net by the weaving yarn 7, and then the plane net is wound to form an oxygenated membrane net, wherein the distance between adjacent weaving knots on the same hollow fiber membrane filament 5 in the plane net is 0.3 cm. In the planar net shown in fig. 2, the hollow fiber membrane filaments 5 are arranged obliquely at an angle of 10 ° (the angle at which the membrane filaments are inclined in the figure is only for the purpose of indicating the inclination, and does not represent the actual inclination angle, i.e., the inclination angle measured in the figure); as in the planar mesh shown in fig. 3. The hollow fiber membrane filaments 5 are arranged in a curve, but other arrangements are also possible. And then the plane net is wound to form an integral oxygenation membrane net. During the process of knitting the oxygenation membrane net, the knitting yarn 7 is selected to be pp material knitting yarn 7, and the specification is selected to be 33F and 22D.

For a single hollow fiber membrane yarn 5, the material is PMP material, the outer diameter is set to 0.32mm, the inner diameter is set to 0.22mm, the length is 10mm, a plurality of fixing grooves for accommodating and fixing the braided wire 7 are arranged on the surface of the hollow fiber membrane yarn, the depth of the fixing grooves is set to 30 μm, the width is set to 94 μm, the hollow fiber membrane yarn 5 comprises a loose layer positioned on the inner side and a compact layer positioned on the outer side, the thickness of the loose layer is set to 59 μm, and the thickness of the compact layer is set to 0.7 μm.

In the case of the oxygenation membrane web, when viewed from the end face, it can be seen that, when viewed from the end face, each hollow fiber membrane filament 5 is distributed in a circular shape, and the specific distribution may be approximately in a matrix distribution (where the matrix distribution refers to approximately in such a distribution, due to the accuracy problem of the planar web during the winding and filling processes, a certain error may be generated, so that a very accurate and perfect matrix or regular distribution may not be presented, but it is considered that at least more than 80% of the hollow fiber membrane filaments 5 are arranged in a manner as described above). In the present embodiment, the hollow fiber membrane yarn 5 can be divided into the smallest regular triangular units when viewed from the end surface, as shown in fig. 9. Of course, it may be distributed in a form other than a matrix, for example, some of the hollow fiber membrane filaments 5 may have a slightly larger and slightly smaller space therebetween. In fig. 9, the hollow fiber membrane filaments 5 are cut into the smallest regular triangular units according to the shape of the end faces, and the interval L1 between the hollow fiber membrane filaments 5 is just equal to 2(0.5d + w). More specifically, L1 is 0.56mm and w is 0.12 mm.

Example four:

an oxygenation membrane net comprises a plurality of hollow fiber membrane filaments 5 which are arranged in the same direction. The same direction as used herein means that the hollow fiber membrane filaments 5 are oriented in the same direction, and does not mean that the angles at which the hollow fiber membrane filaments 5 are arranged are all the same. The arrangement includes a plurality of arrangement modes, a plurality of relatively independent single hollow fiber membrane filaments 5 can be stacked, or a plurality of hollow fiber membrane filaments 5 can be woven to form a plane net and then stacked or wound, so that the hollow fiber membrane filaments 5 are arranged in the same direction, and only the hollow fiber membrane filaments 5 are gathered together in a certain direction according to a certain form. In this embodiment, the hollow fiber membrane filaments 5 are first woven into a single-layer plane net by the weaving yarn 7, and then the plane net is wound to form an oxygenated membrane net, wherein the distance between adjacent weaving knots on the same hollow fiber membrane filament 5 in the plane net is 0.4 cm. In the planar net shown in fig. 2, the hollow fiber membrane filaments 5 are arranged obliquely at an angle of 15 ° (the angle at which the membrane filaments are inclined in the figure is only for the purpose of indicating the inclination, and does not represent the actual inclination angle, i.e., the inclination angle measured in the figure); as in the planar mesh shown in fig. 3. The hollow fiber membrane filaments 5 are arranged in a curve, but other arrangements are also possible. And winding the plane net to form an integral oxygenation membrane net. During the process of knitting the oxygenation membrane net, the knitting yarn 7 is selected to be pp material knitting yarn 7, and the specification is selected to be 44F and 28D.

For a single hollow fiber membrane yarn 5, the material is PMP material, the outer diameter is set to be 0.33mm, the inner diameter is set to be 0.23mm, the length is 10mm, a plurality of fixing grooves for containing and fixing the braided wires 7 are arranged on the surface of the hollow fiber membrane yarn, the depth of each fixing groove is set to be 40 μm, the width of each fixing groove is set to be 96 μm, the hollow fiber membrane yarn 5 comprises a loose layer and a compact layer, the loose layer is located on the inner side, the compact layer is located on the outer side, the thickness of the loose layer is set to be 65 μm, and the thickness of the compact layer is set to be 1 μm.

In the case of the oxygenation membrane web, when viewed from the end face, it can be seen that, when viewed from the end face, each hollow fiber membrane filament 5 is distributed in a circular shape, and the specific distribution may be approximately in a matrix distribution (where the matrix distribution refers to approximately in such a distribution, due to the accuracy problem of the planar web during the winding and filling processes, a certain error may be generated, so that a very accurate and perfect matrix or regular distribution may not be presented, but it is considered that at least more than 80% of the hollow fiber membrane filaments 5 are arranged in a manner as described above). In the present embodiment, the hollow fiber membrane filaments 5 can be divided into the smallest regular triangular units when viewed from the end, as shown in fig. 10. Of course, it may be distributed in a form other than a matrix, for example, some of the hollow fiber membrane filaments 5 may have a slightly larger and slightly smaller space therebetween. In FIG. 10, the hollow fiber membrane filaments 5 are cut into the smallest regular triangular units according to the shape of the end faces of the hollow fiber membrane filaments 5, and the spacing L1 between the hollow fiber membrane filaments 5 is just equal to

More specifically, L1 is 0.59mm and w is 0.18 mm.

Example five:

an oxygenation membrane net comprises a plurality of hollow fiber membrane filaments 5 which are arranged in the same direction. The same direction as used herein means that the hollow fiber membrane filaments 5 are oriented in the same direction, and does not mean that the angles at which the hollow fiber membrane filaments 5 are arranged are all the same. The arrangement includes a plurality of arrangement modes, a plurality of relatively independent single hollow fiber membrane filaments 5 can be stacked, or a plurality of hollow fiber membrane filaments 5 can be woven to form a plane net and then stacked or wound, so that the hollow fiber membrane filaments 5 are arranged in the same direction, and only the hollow fiber membrane filaments 5 are gathered together in a certain direction according to a certain form. In this embodiment, the hollow fiber membrane filaments 5 are first woven into a single-layer plane net by the weaving thread 7, then two single-layer plane nets are laminated and fixed, and then the composite multi-layer plane net is wound to form an oxygenated membrane net, wherein the distance between adjacent weaving knots on the same hollow fiber membrane filament 5 in the plane net is 0.5 cm. Of course, three planar nets can be laminated here; the plane net and the plane net are fixed at the joint point through heat seal, or fixed at the joint point through electrostatic adsorption, etc. In the planar net shown in fig. 4, the hollow fiber membrane filaments 5 are arranged obliquely at an angle of 20 °, and the included angle of the hollow fiber membrane filaments 5 between the two planar nets is set to 5 °; as in the planar mesh shown in fig. 5. The hollow fiber membrane filaments 5 are arranged in a curve, but other arrangements are also possible. And winding the plane net to form an integral oxygenation membrane net. During the process of knitting the oxygenation membrane net, the knitting yarn 7 is selected to be pp material knitting yarn 7, and the specification is selected to be 66F and 40D.

For a single hollow fiber membrane yarn 5, the material is PMP material, the outer diameter is set to 0.34mm, the inner diameter is set to 0.24mm, the length is 10mm, a plurality of fixing grooves for accommodating and fixing the braided wire 7 are arranged on the surface of the hollow fiber membrane yarn, the depth of the fixing grooves is set to 50 μm, the width is set to 98 μm, the hollow fiber membrane yarn 5 comprises a loose layer positioned on the inner side and a compact layer positioned on the outer side, the thickness of the loose layer is set to 71 μm, and the thickness of the compact layer is set to 1.3 μm.

In the case of the oxygenation membrane web, when viewed from the end face, it can be seen that, when viewed from the end face, each hollow fiber membrane filament 5 is distributed in a circular shape, and the specific distribution may be approximately in a matrix distribution (where the matrix distribution refers to approximately in such a distribution, due to the accuracy problem of the planar web during the winding and filling processes, a certain error may be generated, so that a very accurate and perfect matrix or regular distribution may not be presented, but it is considered that at least more than 80% of the hollow fiber membrane filaments 5 are arranged in a manner as described above). In the present embodiment, the hollow fiber membrane yarn 5 can be divided into the smallest square units when viewed from the end surface, as shown in fig. 7. Of course, the hollow fiber membrane filaments 5 may be distributed in a form other than a matrix, for example, the spacing between the hollow fiber membrane filaments may be slightly larger or slightly smaller. In fig. 7, the hollow fiber membrane filaments 5 can be cut into the smallest square units according to the shape of the end faces, and the interval L1 between the hollow fiber membrane filaments 5 is just equal to 2(0.5d + w). More specifically, L1 is 0.62mm and w is 0.14 mm.

Example six:

an oxygenation membrane net comprises a plurality of hollow fiber membrane filaments 5 which are arranged in the same direction. The same direction as used herein means that the hollow fiber membrane filaments 5 are oriented in the same direction, and does not mean that the angles at which the hollow fiber membrane filaments 5 are arranged are all the same. The arrangement includes a plurality of arrangement modes, a plurality of relatively independent single hollow fiber membrane filaments 5 can be stacked, or a plurality of hollow fiber membrane filaments 5 can be woven to form a plane net and then stacked or wound, so that the hollow fiber membrane filaments 5 are arranged in the same direction, and only the hollow fiber membrane filaments 5 are gathered together in a certain direction according to a certain form. In this embodiment, the hollow fiber membrane filaments 5 are first woven into a single-layer plane net by the weaving yarns 7, then two single-layer plane nets are stacked and fixed, and then the composite multi-layer plane net is wound to form an oxygenated membrane net, wherein the distance between adjacent weaving knots on the same hollow fiber membrane filament 5 in the plane net is 0.6 cm. Of course, three planar nets can be laminated here; the plane net and the plane net are fixed at the joint point through heat seal, or fixed at the joint point through electrostatic adsorption, etc. In the planar net shown in fig. 4, the hollow fiber membrane filaments 5 are arranged obliquely at an inclination angle of 25 ° (the inclination angle of the membrane filaments in the figure is only for indicating the inclination and does not represent that the actual inclination angle is the inclination angle measured in the figure), and the included angle of the hollow fiber membrane filaments 5 between the two planar nets is set to be 30 °; as in the planar mesh shown in fig. 5. The hollow fiber membrane filaments 5 are arranged in a curve, but other arrangements are also possible. And winding the plane net to form an integral oxygenation membrane net. During the process of knitting the oxygenation membrane net, the knitting yarn 7 is selected to be pp material knitting yarn 7, and the specification is selected to be 77F and 46D.

For a single hollow fiber membrane yarn 5, the material is PMP, the outer diameter is set to 0.35mm, the inner diameter is set to 0.25mm, the length is 5mm, a plurality of fixing grooves for accommodating and fixing the braided wires 7 are arranged on the surface of the hollow fiber membrane yarn, the depth of each fixing groove is set to 60 μm, the width of each fixing groove is set to 100 μm, the hollow fiber membrane yarn 5 comprises a loose layer located on the inner side and a compact layer located on the outer side, the thickness of the loose layer is set to 77 μm, and the thickness of the compact layer is set to 1.6 μm.

More specifically, L1 is 0.65mm and w is 0.28 mm.

Example seven:

an oxygenation membrane net comprises a plurality of hollow fiber membrane filaments 5 which are arranged in the same direction. The same direction as used herein means that the different hollow fiber membrane filaments 5 are oriented in the same direction, and does not mean that the angles of the hollow fiber membrane filaments 5 are all set to be the same. The arrangement includes a plurality of arrangement modes, a plurality of relatively independent single hollow fiber membrane filaments 5 can be stacked, or a plurality of hollow fiber membrane filaments 5 can be woven to form a plane net and then stacked or wound, so that the hollow fiber membrane filaments 5 are arranged in the same direction, and only the hollow fiber membrane filaments 5 are gathered together in a certain direction according to a certain form. In this embodiment, the hollow fiber membrane filaments 5 are first woven into a single-layer plane net by the weaving thread 7, then two single-layer plane nets are laminated and fixed, and then the composite multi-layer plane net is wound to form an oxygenated membrane net, wherein the distance between adjacent weaving knots on the same hollow fiber membrane filament 5 in the plane net is 0.7 cm. Of course, three planar nets can be laminated here; the plane net and the plane net are fixed at the joint point through heat seal, or fixed at the joint point through electrostatic adsorption, etc. In the planar net shown in fig. 4, the hollow fiber membrane filaments 5 are arranged obliquely at an inclination angle of 30 ° (the inclination angle of the membrane filaments in the figure is only for indicating the inclination and does not represent that the actual inclination angle is the inclination angle measured in the figure), and the included angle of the hollow fiber membrane filaments 5 between the two planar nets is set to 65 °; as in the planar mesh shown in fig. 5. The hollow fiber membrane filaments 5 are arranged in a curve, but other arrangements are also possible. And winding the plane net to form an integral oxygenation membrane net. During the process of knitting the oxygenation membrane net, the knitting yarn 7 is selected to be pp material knitting yarn 7, and the specification is selected to be 88F and 52D.

For a single hollow fiber membrane yarn 5, the material is PMP material, the outer diameter is set to be 0.36mm, the inner diameter is set to be 0.26mm, the length is 10mm, a plurality of fixing grooves for containing and fixing the braided wires 7 are arranged on the surface of the hollow fiber membrane yarn, the depth of each fixing groove is set to be 75 microns, the width of each fixing groove is set to be 105 microns, the hollow fiber membrane yarn 5 comprises a loose layer and a compact layer, the loose layer is located on the inner side, the compact layer is located on the outer side, the thickness of the loose layer is 88 microns, and the thickness of the compact layer is 2.4 microns.

In the case of the oxygenation membrane web, when viewed from the end face, it can be seen that, when viewed from the end face, each hollow fiber membrane filament 5 is distributed in a circular shape, and the specific distribution may be approximately in a matrix distribution (where the matrix distribution refers to approximately in such a distribution, due to the accuracy problem of the planar web during the winding and filling processes, a certain error may be generated, so that a very accurate and perfect matrix or regular distribution may not be presented, but it is considered that at least more than 80% of the hollow fiber membrane filaments 5 are arranged in a manner as described above). In the present embodiment, the hollow fiber membrane yarn 5 can be divided into the smallest regular triangular units when viewed from the end surface, as shown in fig. 9. Of course, the hollow fiber membrane filaments 5 may be distributed in a form other than a matrix, for example, the spacing between the hollow fiber membrane filaments may be slightly larger or slightly smaller. In fig. 9, the hollow fiber membrane filaments 5 are cut into the smallest regular triangular units according to the shape of the end faces, and the interval L1 between the hollow fiber membrane filaments 5 is just equal to 2(0.5d + w). More specifically, L1 is 0.71mm and w is 0.175 mm.

Example eight:

an oxygenation membrane net comprises a plurality of hollow fiber membrane filaments 5 which are arranged in the same direction. The same direction as used herein means that the different hollow fiber membrane filaments 5 are oriented in the same direction, and does not mean that the angles of the hollow fiber membrane filaments 5 are all set to be the same. The arrangement includes many setting modes, and a plurality of relatively independent single hollow fiber membrane filaments 5 can be stacked, or a plurality of hollow fiber membrane filaments 5 can be woven to form a plane net and then stacked or wound, so that the hollow fiber membrane filaments 5 are arranged in the same direction, and only the hollow fiber membrane filaments 5 are gathered together in a certain direction according to a certain form. In this embodiment, the hollow fiber membrane filaments 5 are first woven into a single-layer plane net by the weaving thread 7, then two single-layer plane nets are laminated and fixed, and then the composite multi-layer plane net is wound to form an oxygenated membrane net, wherein the distance between adjacent weaving knots on the same hollow fiber membrane filament 5 in the plane net is 0.8 cm. Of course, three planar nets can be laminated here; the plane net and the plane net are fixed at the joint point through heat seal, or fixed at the joint point through electrostatic adsorption, etc. In the planar net shown in fig. 4, the hollow fiber membrane filaments 5 are arranged obliquely at an inclination angle of 45 ° (the inclination angle of the membrane filaments in the figure is only for indicating the inclination and does not represent that the actual inclination angle is the inclination angle measured in the figure), and the included angle of the hollow fiber membrane filaments 5 between the two planar nets is set to 90 °; as in the planar mesh shown in fig. 5. The hollow fiber membrane filaments 5 are arranged in a curve, but other arrangements are also possible. And winding the plane net to form an integral oxygenation membrane net. During the process of knitting the oxygenation membrane net, the knitting yarn 7 is selected to be pp material knitting yarn 7, and the specification is selected to be 100F and 60D.

For a single hollow fiber membrane yarn 5, the material is PMP material, the outer diameter is set to be 0.4mm, the inner diameter is set to be 0.28mm, the length is 10mm, a plurality of fixing grooves for containing and fixing the braided wires 7 are arranged on the surface of the hollow fiber membrane yarn, the depth of each fixing groove is set to be 90 μm, the width of each fixing groove is set to be 110 μm, the hollow fiber membrane yarn 5 comprises a loose layer and a compact layer, the loose layer is located on the inner side, the compact layer is located on the outer side, the thickness of the loose layer is set to be 99 μm, and the thickness of the compact layer is set to be 3 μm.

In the case of the oxygenation membrane web, when viewed from the end face, it can be seen that, when viewed from the end face, each hollow fiber membrane filament 5 is distributed in a circular shape, and the specific distribution may be approximately in a matrix distribution (where the matrix distribution refers to approximately in such a distribution, due to the accuracy problem of the planar web during the winding and filling processes, a certain error may be generated, so that a very accurate and perfect matrix or regular distribution may not be presented, but it is considered that at least more than 80% of the hollow fiber membrane filaments 5 are arranged in a manner as described above). In the present embodiment, the hollow fiber membrane yarn 5 can be divided into the smallest regular triangular units when viewed from the end surface, as shown in fig. 10. Of course, the hollow fiber membrane filaments 5 may be distributed in a form other than a matrix, for example, the spacing between the hollow fiber membrane filaments may be slightly larger or slightly smaller. In FIG. 10, the hollow fiber membrane filaments 5 may be slit according to their end facesIn the form of the smallest regular triangle unit, the spacing L1 between the hollow fiber membrane filaments 5 is exactly equal to

More specifically, L1 is 0.75mm and w is 0.23 mm.

Example nine:

an oxygenation membrane net comprises a plurality of hollow fiber membrane filaments 5 which are arranged in the same direction. The same direction as used herein means that the hollow fiber membrane filaments 5 are oriented in the same direction, and does not mean that the angles at which the hollow fiber membrane filaments 5 are arranged are all the same. The arrangement includes a plurality of arrangement modes, a plurality of relatively independent single hollow fiber membrane filaments 5 can be stacked, or a plurality of hollow fiber membrane filaments 5 can be woven to form a plane net and then stacked or wound, so that the hollow fiber membrane filaments 5 are arranged in the same direction, and only the hollow fiber membrane filaments 5 are gathered together in a certain direction according to a certain form. In this embodiment, the hollow fiber membrane filaments 5 are vertically arranged and are first woven into a single-layer plane net by the weaving yarn 7, and then the plane net is wound to form an oxygenated membrane net, wherein the distance between adjacent weaving knots on the same hollow fiber membrane filament 5 in the plane net is 0.9 cm. During the process of weaving the oxygenation membrane net, the weaving wire 7 is selected to be a pp material weaving wire 7, and the specification is selected to be 10F and 10D.

In the case of the oxygenation membrane web, when viewed from the end face, it can be seen that, when viewed from the end face, each hollow fiber membrane filament 5 is distributed in a circular shape, and the specific distribution may be approximately in a matrix distribution (where the matrix distribution refers to approximately in such a distribution, due to the accuracy problem of the planar web during the winding and filling processes, a certain error may be generated, so that a very accurate and perfect matrix or regular distribution may not be presented, but it is considered that at least more than 80% of the hollow fiber membrane filaments 5 are arranged in a manner as described above). In the present embodiment, the hollow fiber membrane filaments 5 can be divided into the smallest square units when viewed from the end surface, as shown in fig. 7. Of course, it may be distributed in a form other than a matrix, for example, some of the hollow fiber membrane filaments 5 may have a slightly larger and slightly smaller space therebetween. In fig. 7, the hollow fiber membrane filaments 5 are cut into the smallest square units according to the shape of the end faces, and the interval L1 between the hollow fiber membrane filaments 5 is just equal to 2(0.5d + w). More specifically, L1 is 0.5mm and w is 0.1 mm.

Example ten:

an oxygenation membrane net comprises a plurality of hollow fiber membrane filaments 5 which are arranged in the same direction. The same direction as used herein means that the different hollow fiber membrane filaments 5 are oriented in the same direction, and does not mean that the angles of the hollow fiber membrane filaments 5 are all set to be the same. The arrangement includes a plurality of arrangement modes, a plurality of relatively independent single hollow fiber membrane filaments 5 can be stacked, or a plurality of hollow fiber membrane filaments 5 can be woven to form a plane net and then stacked or wound, so that the hollow fiber membrane filaments 5 are arranged in the same direction, and only the hollow fiber membrane filaments 5 are gathered together in a certain direction according to a certain form. In this embodiment, the hollow fiber membrane filaments 5 are vertically arranged and are first woven into a single-layer plane net by the weaving thread 7, and then the plane net is wound to form an oxygenated membrane net, wherein the distance between adjacent weaving knots on the same hollow fiber membrane filament 5 in the plane net is 1 cm. During the process of weaving the oxygenation membrane net, the weaving wire 7 is selected to be a pp material weaving wire 7, and the specification is selected to be 10F and 10D.

For a single hollow fiber membrane yarn 5, the material is PMP, the outer diameter is set to 0.3mm, the inner diameter is set to 0.2mm, the length is 20mm, a plurality of fixing grooves for accommodating and fixing the braided wires 7 are arranged on the surface of the hollow fiber membrane yarn, the depth of each fixing groove is set to 10 μm, the width of each fixing groove is set to 90 μm, the hollow fiber membrane yarn 5 comprises a loose layer located on the inner side and a compact layer located on the outer side, the thickness of the loose layer is set to 47 μm, and the thickness of the compact layer is set to 0.1 μm.

In the case of the oxygenation membrane web, when viewed from the end face, it can be seen that, when viewed from the end face, each hollow fiber membrane filament 5 is distributed in a circular shape, and the specific distribution may be approximately in a matrix distribution (where the matrix distribution refers to approximately in such a distribution, due to the accuracy problem of the planar web during the winding and filling processes, a certain error may be generated, so that a very accurate and perfect matrix or regular distribution may not be presented, but it is considered that at least more than 80% of the hollow fiber membrane filaments 5 are arranged in a manner as described above). In the present embodiment, the hollow fiber membrane yarn 5 can be divided into the smallest regular triangular units when viewed from the end surface, as shown in fig. 9. Of course, it may be distributed in a form other than a matrix, for example, some of the hollow fiber membrane filaments 5 may have a slightly larger and slightly smaller space therebetween. In fig. 9, the hollow fiber membrane filaments 5 are cut into the smallest regular triangular units according to the shape of the end faces, and the interval L1 between the hollow fiber membrane filaments 5 is just equal to 2(0.5d + w). More specifically, L1 is 0.5mm and w is 0.1 mm.

Example eleven:

an oxygenation membrane net comprises a plurality of hollow fiber membrane filaments 5 which are arranged in the same direction. The same direction as used herein means that the hollow fiber membrane filaments 5 are oriented in the same direction, and does not mean that the angles at which the hollow fiber membrane filaments 5 are arranged are all the same. The arrangement includes a plurality of arrangement modes, a plurality of relatively independent single hollow fiber membrane filaments 5 can be stacked, or a plurality of hollow fiber membrane filaments 5 can be woven to form a plane net and then stacked or wound, so that the hollow fiber membrane filaments 5 are arranged in the same direction, and only the hollow fiber membrane filaments 5 are gathered together in a certain direction according to a certain form. In this embodiment, the hollow fiber membrane filaments 5 are first woven into a single-layer plane net by the weaving yarn 7, and then the plane net is wound to form an oxygenated membrane net, wherein the distance between adjacent weaving knots on the same hollow fiber membrane filament 5 in the plane net is 0.1 cm. In the planar net shown in fig. 2, the hollow fiber membrane filaments 5 are arranged obliquely at an angle of 30 °; as in the planar mesh shown in fig. 3. The hollow fiber membrane filaments 5 are arranged in a curve, but other arrangements are also possible. And winding the plane net to form an integral oxygenation membrane net. During the process of knitting the oxygenation membrane net, the knitting yarn 7 is selected to be pp material knitting yarn 7, and the specification is selected to be 10F and 10D.

To single hollow fiber membrane silk 5, its material is the PP material, the external diameter sets up to 0.3mm, the internal diameter sets up to 0.2mm, its length is 20mm, be provided with a plurality of fixed slots that are used for holding, fixed braided wire 7 on its surface, the degree of depth of fixed slot sets up to 10 mu m, the width sets up to 90 mu m, and hollow fiber membrane silk 5 is including being located inboard loose layer and being located the compact layer in the outside, the thickness on loose layer sets up to 47 mu m, the thickness on compact layer sets up to 0.1 mu m.

In the case of the oxygenation membrane web, when viewed from the end face, it can be seen that, when viewed from the end face, each hollow fiber membrane filament 5 is distributed in a circular shape, and the specific distribution may be approximately in a matrix distribution (where the matrix distribution refers to approximately in such a distribution, due to the accuracy problem of the planar web during the winding and filling processes, a certain error may be generated, so that a very accurate and perfect matrix or regular distribution may not be presented, but it is considered that at least more than 80% of the hollow fiber membrane filaments 5 are arranged in a manner as described above). In the present embodiment, the hollow fiber membrane yarn 5 can be divided into the smallest square units when viewed from the end surface, as shown in fig. 7. Of course, the hollow fiber membrane filaments 5 may be distributed in a form other than a matrix, for example, the spacing between the hollow fiber membrane filaments may be slightly larger or slightly smaller. In fig. 7, the hollow fiber membrane filaments 5 can be cut into the smallest square units according to the shape of the end faces, and the interval L1 between the hollow fiber membrane filaments 5 is just equal to 2(0.5d + w). More specifically, L1 is 0.5mm and w is 0.1 mm.

Example twelve:

an oxygenation membrane net comprises a plurality of hollow fiber membrane filaments 5 which are arranged in the same direction. The same direction as used herein means that the hollow fiber membrane filaments 5 are oriented in the same direction, and does not mean that the angles at which the hollow fiber membrane filaments 5 are arranged are all the same. The arrangement includes a plurality of arrangement modes, a plurality of relatively independent single hollow fiber membrane filaments 5 can be stacked, or a plurality of hollow fiber membrane filaments 5 can be woven to form a plane net and then stacked or wound, so that the hollow fiber membrane filaments 5 are arranged in the same direction, and only the hollow fiber membrane filaments 5 are gathered together in a certain direction according to a certain form. In this embodiment, the hollow fiber membrane filaments 5 are first woven into a single-layer plane net through the weaving yarns 7, then two single-layer plane nets are stacked and fixed, and then the composite multi-layer plane net is wound to form an oxygenated membrane net, wherein the distance between adjacent weaving knots on the same hollow fiber membrane filament 5 in the plane net is 0.8 cm. Of course, three planar nets can be laminated here; the plane net and the plane net are fixed at the joint point through heat seal, or fixed at the joint point through electrostatic adsorption, etc. In the planar net shown in fig. 4, the hollow fiber membrane filaments 5 are arranged obliquely at an inclination angle of 45 ° (the inclination angle of the membrane filaments in the figure is only for indicating the inclination and does not represent that the actual inclination angle is the inclination angle measured in the figure), and the included angle of the hollow fiber membrane filaments 5 between the two planar nets is set to 90 °; as in the planar mesh shown in fig. 5. The hollow fiber membrane filaments 5 are arranged in a curve, but other arrangements are also possible. And winding the plane net to form an integral oxygenation membrane net. During the process of knitting the oxygenation membrane net, the knitting yarn 7 is selected to be pp material knitting yarn 7, and the specification is selected to be 100F and 60D.

For a single hollow fiber membrane yarn 5, the material is PP material, the outer diameter is set to be 0.4mm, the inner diameter is set to be 0.28mm, the length is 10mm, a plurality of fixing grooves used for containing and fixing braided wires 7 are arranged on the surface of the hollow fiber membrane yarn, the depth of each fixing groove is set to be 90 microns, the width of each fixing groove is set to be 110 microns, the hollow fiber membrane yarn 5 comprises a loose layer located on the inner side and a compact layer located on the outer side, the thickness of the loose layer is set to be 99 microns, and the thickness of the compact layer is set to be 3 microns.

The end face of the oxygenation membrane net is observedIn view of the above, the hollow fiber membrane filaments 5 are distributed in a circular shape, and the specific distribution may be a substantially matrix distribution (the matrix distribution is a substantially matrix distribution, which may cause a certain error due to the precision problem of the planar net during the winding and filling processes, and thus may not present a very precise and perfect matrix or regular distribution, but it may be considered that at least more than 80% of the hollow fiber membrane filaments 5 are disposed in a manner corresponding thereto). In the present embodiment, the hollow fiber membrane yarn 5 can be divided into the smallest regular triangular units when viewed from the end surface, as shown in fig. 10. Of course, it may be distributed in a form other than a matrix, for example, some of the hollow fiber membrane filaments 5 may have a slightly larger and slightly smaller space therebetween. In FIG. 10, the hollow fiber membrane filaments 5 are cut into the smallest regular triangular units according to the shape of the end faces of the hollow fiber membrane filaments 5, and the spacing L1 between the hollow fiber membrane filaments 5 is just equal to

More specifically, L1 is 0.75mm and w is 0.23 mm.

Comparative example one:

comparative example one compared to example nine, the difference is that L1 is 1 mm.

Comparative example two:

comparative example two the difference compared to example ten is that L1 is 1 mm.

Comparative example three:

comparative example three compared to example eleven, the difference is that L1 is 1 mm.

Comparative example four:

comparative example four the difference compared to example twelve is that L1 is 1 mm.

Also disclosed in the present application is an oxygenation assembly 8, as shown in fig. 1. Comprises a shell and an oxygen-containing membrane wound in the shell, wherein the shell is provided with a liquid inlet 3, a liquid outlet 4, an air inlet 1 and an air outlet 2. And an air passage is formed by the air inlet 1, the air outlet 2 and the interior of the hollow fiber membrane filament 5 of the oxygen-containing membrane. A cavity is formed between the outer side wall of the hollow fiber membrane wire 5 and the shell, and a flow passage is formed by the liquid inlet 3, the cavity and the liquid outlet 4. The hollow fiber membrane filaments 5 are provided with sealing members 6 for sealing between the hollow fiber membrane filaments 5 and the hollow fiber membrane filaments 5, and between the hollow fiber membrane filaments 5 and the housing, at positions near both ends. Further, the air inlet 1 is opposite to one end opening of the hollow fiber membrane filament 5, and the air outlet 2 is opposite to the other end opening of the hollow fiber membrane filament 5. To illustrate the advantages of the hollow fiber membrane web of the present solution over the prior art, we installed the oxygenation membrane webs of examples one to twelve and comparative examples one to four into the oxygenation module 8 disclosed in this application. And the relevant performance of the device in use is respectively tested and recorded, and the blood oxygen content value is mainly detected.

The specific experimental method is as follows, referring to the Chinese people's republic of China medical and drug industry standard YY0604, the blood adopts anticoagulated bovine blood collected on the same day, and the blood and gas indexes of the bovine blood are firstly adjusted to the numerical value range required in the industry standard YY 0604. The hollow fiber membrane wire 5 is manufactured into a test oxygenator with the outer surface area of 0.1m2 through the processes of weaving, packaging and the like. And then, a test oxygenator is connected into the blood circulation loop, the blood flow rate is adjusted to 400mL/min, the flow rate of pure oxygen is adjusted to 400mL/min, after the blood circulation is stable, venous blood before oxygenation and arterial blood after oxygenation are collected for blood-gas analysis, and finally, the mass transfer rate of oxygen and carbon dioxide and the gas separation factor under the external surface area of a unit membrane wire are calculated, which is detailed in the table I below.

Table one:

from the above table one, it can be found that the gas exchange efficiency of the samples of comparative examples one to four is significantly lower than that of the product according to the present application, that is, the space between the hollow fiber membrane filaments 5 satisfies the conditions defined in the present application, and the efficiency of the blood in oxygen-carbon dioxide gas exchange can be improved. Furthermore, by comparing the data, when the material of the hollow fiber membrane filaments 5 is the same, the gas mass transfer efficiency of the single-layer oxygenation membrane net is slightly lower than that of the double-layer oxygenation membrane net; when the hollow fiber membrane wires 5 are inclined to form the oxygenation membrane net, compared with the condition that the hollow fiber membrane wires 5 and the braided wires 7 are vertically arranged, the whole oxygenation membrane net has slightly higher gas exchange efficiency.

While the preferred embodiments of the present invention have been illustrated and described in detail, it should be understood that various changes and modifications of the invention can be effected therein by those skilled in the art after reading the above teachings of the invention. Such equivalents are intended to fall within the scope of the claims appended hereto.

Claims

1. The utility model provides an oxygenation membrane net, includes that a plurality of hollow fiber membrane silks are arranged in the syntropy and are constituteed, the position is relatively fixed between the hollow fiber membrane silk, its characterized in that: the outer diameter of the hollow fiber membrane filaments is set to d, the distance between the adjacent hollow fiber membrane filaments is set to L1, a hollow columnar high-efficiency exchange area concentric with the cross-sectional circle of the hollow fiber membrane filaments is formed outside the hollow fiber membrane filaments, the oxygen mass transfer rate in the high-efficiency exchange area is at least 50 mL/(min. square meter) @400mL/min blood flow rate @400mL/min oxygen flow rate, a gas separation factor alpha (CO2/O2) is set between 1 and 4, the width of the minimum position of the high-efficiency exchange area is set to w, and L1 is not more than 2(0.5d + w).

2. The oxygenation membrane web of claim 1, wherein the L1 is less than or equal to when three adjacent hollow fiber membrane filaments of the plurality of hollow fiber membrane filaments are triangular

(0.5d + w); when four adjacent hollow fiber membrane filaments are square, L1 is less than or equal to

(0.5d+w)。

3. The oxygenation membrane web of claim 2, wherein the carbon dioxide mass transfer rate in the high efficiency exchange zone is at least 100mL/(min square meter) @400mL/min blood flow rate @400mL/min oxygen flow rate.

4. The oxygenation membrane web of claim 1, 2 or 3, characterized in that the hollow fiber membrane filaments are provided with a length of L2, 145L 1L 2L 1.

5. The oxygenation membrane web of claim 4, wherein the spacing L1 between the hollow fiber membrane filaments is set between 0.5mm-0.75 mm.

6. The oxygenation membrane web of claim 5, wherein at least one of the hollow fiber membrane filaments partially overlaps its adjacent hollow fiber membrane filament in a radial projection.

7. The oxygenation membrane net of claim 6, wherein the hollow fiber membrane filaments are arranged in a straight line type, and a plurality of hollow fiber membrane filaments are woven into a single-layer plane net by a weaving thread, and the hollow fiber membrane filaments are arranged vertically or obliquely in the radial direction; the single-layer plane net or the multiple-layer plane net is wound to form the oxygenated membrane net.

8. The oxygenation membrane web of claim 7, wherein the hollow fiber membrane filaments are spaced apart by a braided knot of braided wire.

9. The oxygenation membrane web of claim 8, wherein the spacing of adjacent braided knots on the same hollow fiber membrane filament is set between 0.1cm and 1 cm.

10. The oxygenation membrane web of claim 7, wherein the hollow fiber membrane filaments are inclined at an angle of between 0 ° and 45 °.

11. The oxygenation membrane web of claim 7, wherein when the oxygenation membrane web is a multilayer planar web, the hollow fiber membrane filaments in two adjacent layers of planar webs are arranged at an included angle of between 5 ° and 90 °.

12. The oxygenation membrane web of claim 11, wherein bonding points are provided between the adjacent planar webs.

13. The oxygenation membrane web of claim 1, wherein the hollow fiber membrane filaments have an outer diameter of between 0.3mm and 0.4mm and an inner diameter of between 0.2mm and 0.28 mm.

14. The oxygenated membrane web of claim 1 or 13, wherein the hollow fiber membrane filaments comprise a loose layer on the inside and a dense layer on the outside.

15. The oxygenation membrane web of claim 14, wherein the dense layer is provided between 0.1-3 μ ι η thick and the loose layer is provided between 47-99 μ ι η thick.

16. The oxygenation membrane net of claim 7, wherein the braided wire includes but is not limited to PP, PET, N6, N66 and their blends, with gauge selected between 10F-100F, 10D-60D.

17. An oxygenation module made by using the oxygenation membrane net of claim 1, comprising a housing, and an oxygenation membrane wound in the housing, wherein the housing is provided with a liquid inlet, a liquid outlet, a gas inlet and a gas outlet, the gas inlet, the gas outlet and the hollow fiber membrane filaments of the oxygenation membrane form a gas passage inside, a cavity is formed between the outer side wall of the hollow fiber membrane filaments and the housing, the liquid inlet, the cavity and the liquid outlet form a flow passage, the single hollow fiber membrane filament is spirally arranged around the winding axis of the oxygenation membrane, and the spiral inclination angles of the hollow fiber membrane filaments in the adjacent membrane layers in the oxygenation membrane are different.

18. The oxygenation assembly of claim 17, wherein the hollow fiber membrane filaments are provided with a seal near each end to seal between the hollow fiber membrane filaments and the hollow fiber membrane filaments, and between the hollow fiber membrane filaments and the housing.

19. The oxygenation assembly of claim 17 or 18, wherein the gas inlet is open opposite one end of the hollow fiber membrane filaments and the gas outlet is open opposite the other end of the hollow fiber membrane filaments.