CN109364314B - Double-cavity membrane type oxygenator and oxygenation method - Google Patents
Double-cavity membrane type oxygenator and oxygenation method Download PDFInfo
- Publication number
- CN109364314B CN109364314B CN201811493014.6A CN201811493014A CN109364314B CN 109364314 B CN109364314 B CN 109364314B CN 201811493014 A CN201811493014 A CN 201811493014A CN 109364314 B CN109364314 B CN 109364314B
- Authority
- CN
- China
- Prior art keywords
- blood
- communicated
- oxygenation chamber
- gas
- cover
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000006213 oxygenation reaction Methods 0.000 title claims abstract description 206
- 239000012528 membrane Substances 0.000 title claims abstract description 69
- 238000000034 method Methods 0.000 title claims abstract description 33
- 239000007789 gas Substances 0.000 claims abstract description 201
- 239000008280 blood Substances 0.000 claims abstract description 175
- 210000004369 blood Anatomy 0.000 claims abstract description 175
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 108
- 239000001301 oxygen Substances 0.000 claims abstract description 108
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 105
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 68
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 34
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 34
- 239000012510 hollow fiber Substances 0.000 claims description 95
- 230000006835 compression Effects 0.000 claims description 29
- 238000007906 compression Methods 0.000 claims description 29
- 230000000903 blocking effect Effects 0.000 claims description 22
- 230000017531 blood circulation Effects 0.000 claims description 14
- 230000009977 dual effect Effects 0.000 claims description 10
- 230000004087 circulation Effects 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 3
- 239000003054 catalyst Substances 0.000 claims description 2
- 238000010586 diagram Methods 0.000 description 7
- 102000001554 Hemoglobins Human genes 0.000 description 2
- 108010054147 Hemoglobins Proteins 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 238000003475 lamination Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 101100243025 Arabidopsis thaliana PCO2 gene Proteins 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1698—Blood oxygenators with or without heat-exchangers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
Abstract
The invention discloses a double-cavity membrane type oxygenator which comprises an upper cover, a lower cover, a middle connecting cover, a mandrel structure, a first oxygenation chamber and a second oxygenation chamber, wherein the upper cover is connected with the lower cover; the first oxygenation chamber and the second oxygenation chamber comprise an oxygen pressing film and a plugging layer and are respectively communicated with the blood path interface; the mandrel structure comprises an upper mandrel, a lower mandrel and a mandrel connecting block for connecting the upper mandrel and the lower mandrel, wherein the upper mandrel and the lower mandrel are communicated with each other through a connecting shaft, and the upper mandrel and the lower mandrel are communicated with the oxygen film; the upper cover, the middle connecting cover and the lower cover are communicated with an air port; the upper part and the lower part of the first oxygenation chamber are respectively connected with the upper cover and the middle connecting cover; the upper part and the lower part of the second oxygenation chamber are respectively connected with the middle connecting cover and the lower cover; the invention also discloses a double-cavity membrane type oxygenation method. When the blood exchanges gas, the carbon dioxide content and the oxygen content can be effectively and accurately adjusted according to the requirements.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a double-cavity membrane type oxygenator and an oxygenation method.
Background
A hollow fiber membrane type oxygenator (hereinafter referred to as oxygenator) is an alloy standard for current blood oxygenation, and is gradually applied to more medical fields such as respiratory support, emergency treatment, etc. from the beginning of a long-term use of the oxygenator as an instrument for supporting heart surgery.
The binding capacity of hemoglobin in blood to oxygen is affected by the partial pressure of carbon dioxide (PCO 2), and when PCO2 is elevated, the binding capacity of hemoglobin to oxygen decreases. When the oxygenator completes the exchange of the blood and the gas, the oxygen concentration difference of the blood side and the gas side directly influences the oxygenation effect of the blood, and the partial pressure of the carbon dioxide is mainly related to the flow speed of the gas.
The membrane oxygenator in the market at present is designed as a single gas exchange cavity, and only one gas or mixed gas with the same concentration can be introduced when the membrane oxygenator is used, so that the gas needs to keep a certain oxygen concentration for adjusting the oxygen content in blood and ensure a certain air flow rate to ensure the quick removal of carbon dioxide when flowing through the oxygenator, and the blood oxygen content and the carbon dioxide content in blood cannot be effectively and quickly adjusted when the membrane oxygenator is used. And causes a great deal of waste of gas, especially when the respiratory department or the applicable subject is the elderly, and requires better carbon dioxide removal capability when in use.
Disclosure of Invention
In view of the foregoing, it is desirable to provide a dual-chamber membrane oxygenator and an oxygenation method, which can effectively adjust the carbon dioxide content in blood while effectively adjusting the blood oxygen content in blood when applied to oxygenation of blood, and can be used as a single oxygenator or a single carbon dioxide remover.
In order to achieve the above purpose, the technical scheme of the invention is realized as follows:
the embodiment of the invention provides a double-cavity membrane oxygenator which comprises an upper cover, a lower cover, a middle connecting cover, a mandrel structure, a first oxygenation chamber and a second oxygenation chamber, wherein the upper cover is connected with the lower cover; the first oxygenation chamber and the second oxygenation chamber comprise an oxygen pressing film and blocking layers arranged at the top and the bottom of the oxygen pressing film, and are respectively communicated with a blood path interface; the mandrel structure comprises an upper mandrel, a lower mandrel and a mandrel connecting block for connecting the upper mandrel and the lower mandrel, wherein the upper mandrel and the lower mandrel are communicated with each other through a connecting shaft, and the upper mandrel and the lower mandrel are communicated with the oxygen film pressing gap; the upper cover, the middle connecting cover and the lower cover are communicated with an air port; the top and the bottom of the first oxygenation chamber are respectively connected with the upper cover and the middle connecting cover; the top and the bottom of the second oxygenation chamber are respectively connected with the middle connecting cover and the lower cover.
Further, the oxygen compression film is composed of a hollow fiber tube, and the blocking layer is in a honeycomb structure.
Further, the plugging layer of the honeycomb structure is connected with the pipe orifice of the hollow fiber pipe in an aligned mode.
Further, the upper cover is communicated with a first air inlet, the middle connecting cover is communicated with a first air outlet and a second air inlet, and the lower cover is communicated with a second air outlet.
Further, a bolt switch for blocking or communicating the gas circulation in the first oxygenation chamber and the second oxygenation chamber is arranged in the middle connecting cover.
Further, the first oxygenation chamber and the second oxygenation chamber are respectively communicated with a blood path interface, and the blood path interface comprises:
the bottom of the first oxygenation chamber is communicated with a blood path connector, and the bottom of the second oxygenation chamber is communicated with a blood inlet path connector;
or the bottom of the first oxygenation chamber is communicated with the blood inlet port, and the bottom of the second oxygenation chamber is communicated with the blood outlet port.
The embodiment of the invention also provides a double-cavity membrane type oxygenator, which comprises the following steps:
after the blood exchanges gas through the first oxygenation chamber, the blood enters the upper mandrel side wall space and enters the lower mandrel side wall space through a connecting shaft which is communicated with the upper mandrel side wall space and the lower mandrel side wall space;
and the blood enters the second oxygenation chamber from the side wall space of the lower mandrel, is subjected to gas exchange again, and is discharged.
Further, the method further comprises:
the gas in the first oxygenation chamber and the gas in the second oxygenation chamber may not be communicated or intercommunicated.
The embodiment of the invention further provides a double-cavity membrane type oxygenator, and the method comprises the following steps of:
after the blood exchanges gas through the second oxygenation chamber, the blood enters the lower mandrel side wall space and enters the upper mandrel side wall space through a connecting shaft which is communicated with the lower mandrel side wall space and the upper mandrel side wall space;
and the blood enters the first oxygenation chamber from the side wall space of the upper mandrel, is subjected to gas exchange again, and is discharged.
Further, the method further comprises:
the gas in the second oxygenation chamber may not be in communication or in communication with the gas in the first oxygenation chamber.
The invention has the following beneficial effects: 1) The invention can effectively solve the problems of oxygen exchange and carbon dioxide removal when applied to blood oxygenation, and improves the oxygenation efficiency; 2) The invention can also be used as a single oxygenator; 3) The present invention may also be used as a separate carbon dioxide remover.
Drawings
FIG. 1 is a perspective view of a dual chamber membrane oxygenator in accordance with embodiments of the present invention;
FIG. 2 is a cross-sectional view of a dual-chamber membrane oxygenator in accordance with an embodiment of the present invention;
FIG. 3 (a) is a schematic plan view showing the structure of a mandrel in a dual-chamber membrane oxygenator according to an embodiment of the present invention;
FIG. 3 (b) is a diagram of the inside of the upper mandrel in a dual chamber membrane oxygenator according to an embodiment of the present invention;
FIG. 4 is a schematic bottom-up flow of blood in a dual-lumen membrane oxygenator in accordance with an embodiment of the present invention;
FIG. 5 is a schematic illustration of a first gas flow pattern in a dual chamber membrane oxygenator in accordance with an embodiment of the present invention;
FIG. 6 is a schematic top-down flow of blood in a dual-lumen membrane oxygenator according to an embodiment of the present invention;
FIG. 7 is a schematic illustration of a second gas flow pattern in a dual chamber membrane oxygenator in accordance with an embodiment of the present invention;
FIG. 8 is a schematic illustration of a first flow scheme of a dual-chamber membrane oxygenation process according to an embodiment of the invention;
FIG. 9 is a schematic illustration of a second flow scheme of a dual chamber membrane oxygenation process according to an embodiment of the invention;
wherein: 1 is an upper cover, 2 is a lower cover, 3 is an intermediate connection cover, 4 is a first oxygenation chamber, 5 is a second oxygenation chamber, 6 is a first air inlet, 7 is a first air outlet, 8 is a second air inlet, 9 is a second air outlet, 10 is a blood path interface, 11 is an oxygen film in the first oxygenation chamber, 12 is an oxygen film in the second oxygenation chamber, 13 is a plugging layer, 14 is an upper mandrel, 15 is a lower mandrel, 16 is a mandrel connection block, 17 is an upper mandrel side wall space, 18 is a lower mandrel side wall space, and 19 is a connection shaft.
Detailed Description
So that the manner in which the features and objects of the present invention can be understood in more detail, a more particular description of the invention, briefly summarized above, may be had by reference to the appended drawings, which are not necessarily limited to the embodiments described.
Fig. 1 is a perspective view of a dual-cavity membrane oxygenator according to an embodiment of the present invention, as shown in fig. 1, the dual-cavity membrane oxygenator includes an upper cover 1, a lower cover 2, an intermediate connection cover 3, a first oxygenation chamber 4 between the upper cover 1 and the intermediate connection cover 3, and a second oxygenation chamber 5 between the intermediate connection cover 3 and the lower cover 2, wherein the upper cover 1 is communicated with a first air inlet 6, the intermediate connection cover 3 is communicated with a first air outlet 7 and a second air inlet 8, the lower cover 2 is communicated with a second air outlet 9, and the first oxygenation chamber 4 and the second oxygenation chamber 5 are respectively communicated with a blood path interface 10.
The specific internal structure is shown in fig. 2, and fig. 2 is a sectional structure diagram of a double-cavity membrane oxygenator in the embodiment of the invention, and the double-cavity membrane oxygenator comprises an upper cover 1, a lower cover 2, a middle connecting cover 3, a mandrel structure, a first oxygenation chamber 4 and a second oxygenation chamber 5; the first oxygenation chamber 4 and the second oxygenation chamber 5 comprise an oxygen pressing film and blocking layers 13 arranged at the top and the bottom of the oxygen pressing film, and are respectively communicated with a blood path interface 10; the mandrel structure comprises an upper mandrel 14, a lower mandrel 15 and a mandrel connecting block 16 for connecting the upper mandrel 14 and the lower mandrel 15, wherein the sidewall space of the upper mandrel 14 and the sidewall space of the lower mandrel 15 are communicated through a connecting shaft 19, and the sidewall space 17 of the upper mandrel and the sidewall space 18 of the lower mandrel are both communicated with the oxygen film; the upper cover 1, the middle connecting cover 3 and the lower cover 2 are communicated with air ports; the top and the bottom of the first oxygenation chamber 4 are respectively connected with the upper cover 1 and the middle connecting cover 3; the top and the bottom of the second oxygenation chamber 5 are respectively connected with the middle connecting cover 3 and the lower cover 2.
Further, the oxygen compression film is composed of a hollow fiber tube, and the blocking layer is in a honeycomb structure.
Further, the plugging layer 13 of the honeycomb structure is aligned with the orifice of the hollow fiber tube.
Further, the upper cover 1 is communicated with a first air inlet 6, the middle connecting cover 3 is communicated with a first air outlet 7 and a second air inlet 8, and the lower cover 2 is communicated with a second air outlet 9.
Here, the gas introduced from the first gas inlet 6 communicating with the upper cover 1 enters the hollow fiber tube through the plugging layer 13 of the honeycomb structure and exits from the plugging layer 13 of the honeycomb structure below.
The oxygen compression film here includes an oxygen compression film 11 in the first oxygenation chamber, and an oxygen compression film 12 in the second oxygenation chamber.
Further, a plug switch for blocking or communicating the gas flow in the first oxygenation chamber 4 and the second oxygenation chamber 5 is provided in the intermediate connection cover 3.
Here, the middle connecting cover 3 has an independent two-layer structure, when the bolt switch arranged in the middle connecting cover 3 is closed, the first air outlet 7 communicated with the middle connecting cover 3 is not communicated with the second air inlet 8, namely, the two-layer structure works, and accordingly, the air circulation in the first oxygenation chamber 4 and the second oxygenation chamber 5 is blocked; when the latch switch arranged in the intermediate connection cover 3 is opened, the first air outlet communicated with the intermediate connection cover 3 is communicated with the second air inlet, and accordingly, the first oxygenation chamber 4 is communicated with the air flow in the second oxygenation chamber 5, at this time, the second air inlet 8 needs to be plugged, that is, the second air inlet 8 is not filled with air, or the air filled from the second air inlet 8 is directly discharged from the first air outlet 7.
Further, the first oxygenation chamber 4 and the second oxygenation chamber 5 are respectively communicated with a blood path interface 10, and include:
the bottom of the first oxygenation chamber 4 is communicated with a blood path connector, and the bottom of the second oxygenation chamber 5 is communicated with a blood path connector;
or the bottom of the first oxygenation chamber 4 is communicated with a blood inlet port, and the bottom of the second oxygenation chamber 5 is communicated with a blood outlet port.
Here, when the bottom of the first oxygenation chamber 4 is communicated with the blood path interface, and the bottom of the second oxygenation chamber 5 is communicated with the blood path interface, a power pump is arranged on the blood path interface communicated with the bottom of the second oxygenation chamber 5 to provide the power for the blood to flow from bottom to top.
Here, when blood enters the oxygenation chamber through the blood inlet port, the blood fills the oxygen compression membrane formed by a plurality of hollow fiber tubes, that is, the blood is spread on the outer wall of the hollow fiber tubes and separated from the gas flowing in the hollow fiber tubes.
Fig. 3 (a) is a schematic plan view of a mandrel structure in a dual-chamber membrane oxygenator according to an embodiment of the present invention, and as shown in the drawing, the mandrel structure includes an upper mandrel 14, a lower mandrel 15, and a mandrel connecting block 16 connecting the upper mandrel 14 and the lower mandrel 15.
Here, the mandrel structure is arranged at the middle part of the double-cavity membrane type oxygenator, the center of the mandrel structure is a solid structure, the upper mandrel side wall space 17 and the lower mandrel side wall space 18 are communicated with the oxygen membrane pressing gap, and the upper mandrel side wall space 17 and the lower mandrel side wall space 18 are communicated through a connecting shaft.
Here, the upper mandrel sidewall space 17 and the lower mandrel sidewall space 18 have a slit 171 through which blood passes on the side in contact with the oxygen lamination gap, and thus both the upper mandrel sidewall space 17 and the lower mandrel sidewall space 18 communicate with the oxygen lamination gap.
Fig. 3 (b) is a diagram showing the inner side of the upper mandrel in the dual-chamber membrane oxygenator according to the embodiment of the present invention, wherein the middle of the upper mandrel 14 is a solid structure, the side wall forms a space 17, and a gap 171 through which blood passes is formed at the side contacting the oxygen membrane pressing gap.
Fig. 4 is a schematic view showing a flow of blood from bottom to top in the dual-cavity membrane oxygenator according to the embodiment of the present invention, as shown in fig. 4, a blood inlet port is disposed at the bottom of the second oxygenation chamber, and a blood outlet port is disposed at the bottom of the first oxygenation chamber.
Here, when blood enters the second oxygenation chamber from the blood inlet port, the blood fills the oxygen compression film formed by a plurality of hollow fiber tubes, namely, the blood is fully distributed on the outer wall of the hollow fiber tubes, and after being exchanged with gas molecules flowing in the hollow fiber tubes, the blood flows upwards through the lower mandrel side wall space communicated with the oxygen compression film, sequentially passes through the connecting shaft connecting the lower mandrel and the upper mandrel side wall space, then enters the first oxygenation chamber, and is fully distributed on the outer wall of the hollow fiber tubes, and after being exchanged with the gas molecules flowing in the hollow fiber tubes, the blood is discharged from the blood inlet port arranged at the bottom of the first oxygenation chamber.
Here, the molecular exchange of the gas in the second oxygenation chamber by the blood may specifically be to control the partial pressure of carbon dioxide in the blood by adjusting the speed at which the gas flows in the hollow fiber tube.
Here, the molecular exchange of the gas in the first oxygenation chamber may specifically be to control the oxygen partial pressure and the blood oxygen saturation in the blood by adjusting the oxygen concentration in the gas, for example, the first oxygenation chamber is filled with an air-oxygen mixed gas with the oxygen concentration of 66% to raise the oxygen partial pressure and the blood oxygen saturation in the blood to the clinical requirements of the operation.
The above described realizes the two complete gas exchange processes of blood in the double-cavity membrane oxygenator of the present example, and the specific gas flow mode is shown in fig. 5.
Fig. 5 is a schematic diagram of a first gas flow mode in the dual-cavity membrane oxygenator according to the embodiment of the present invention, as shown in the drawing, the gas respectively enters from the first gas inlet communicated with the upper cover and the second gas inlet communicated with the middle connecting cover, and respectively exits from the first gas outlet communicated with the middle connecting cover and the second gas outlet communicated with the lower cover.
Here, the intermediate connection cover has a separate two-layer structure therein.
Here, the latch switch provided in the intermediate connection cover is closed, that is, the gas flow in the first oxygenation chamber and the gas flow in the second oxygenation chamber are blocked, so that the independent two-layer structure provided in the intermediate connection cover independently works, that is, the gas does not flow from the second gas inlet communicated with the intermediate connection cover to the first gas outlet communicated with the intermediate connection cover.
Here, the gas enters from the second gas inlet communicated with the middle connecting cover, enters into a plurality of hollow fiber pipes communicated with the second gas inlet through the honeycomb-shaped plugging layer, and exits from the honeycomb-shaped plugging layer connected with the bottom end of the hollow fiber pipe, and finally exits from the second gas outlet communicated with the lower cover.
Here, the gas enters through the second gas inlet communicated with the middle connecting cover, is distributed with the middle connecting cover for a circle with independent working structure layers, and flows downwards through the honeycomb-shaped blocking layers.
Similarly, the gas enters from the first air inlet communicated with the upper cover, enters into a plurality of hollow fiber tubes communicated with the upper cover through the honeycomb-shaped blocking layer, and exits from the honeycomb-shaped blocking layer connected with the bottom ends of the hollow fiber tubes, and finally exits from the first air outlet communicated with the middle connecting cover.
Here, the gas enters from the first air inlet communicated with the upper cover, is distributed over the upper cover for a circle, flows downwards through the cellular plugging layer, and finally, after exiting from the cellular plugging layer connected with the bottom end of the hollow fiber tube, is distributed over the middle connecting cover for a circle with an independent working structure layer, and exits from the first air outlet communicated with the middle connecting cover.
Here, the gas entering from the second gas inlet communicating with the intermediate connection cover may be subjected to gas flow rate adjustment by an additional member, and the partial pressure of carbon dioxide in blood may be controlled by adjusting the speed at which the gas flows in the hollow fiber tube.
Here, the gas introduced from the first gas inlet communicating with the upper cover contains an appropriate amount of oxygen concentration, and the partial pressure of oxygen and the saturation of blood oxygen in blood are controlled by adjusting the oxygen concentration of the gas flowing through the hollow fiber tube.
Here, the dual-lumen membrane oxygenator operates with gas flow concurrent with blood flow.
Fig. 6 is a schematic diagram showing a flow of blood from top to bottom in the dual-cavity membrane oxygenator according to the embodiment of the present invention, as shown in fig. 6, the blood enters from a blood inlet port communicated with the bottom of a first oxygenation chamber, fills an oxygen compression membrane formed by a plurality of hollow fiber tubes, that is, the blood is fully distributed on the outer wall of the hollow fiber tubes, flows downwards through an upper mandrel side wall space communicated with the oxygen compression membrane after exchanging with gas molecules flowing in the hollow fiber tubes, sequentially passes through a connecting shaft connecting the lower mandrel with the upper mandrel side wall space and a lower mandrel side wall space, then enters into a second oxygenation chamber, and is fully distributed on the outer wall of the hollow fiber tubes after exchanging with gas molecules flowing in the hollow fiber tubes, and then exits from a blood inlet port arranged at the bottom of the second oxygenation chamber.
Here, it should be noted that the dual-chamber membrane oxygenator is three-dimensional cylindrical, and only one blood path interface is needed for blood to enter and exit in the first oxygenation chamber and the second oxygenation chamber respectively.
Here, the molecular exchange of the gas in the first oxygenation chamber by the blood may specifically be to control the partial pressure of carbon dioxide in the blood by adjusting the speed at which the gas flows in the hollow fiber tube.
Here, the molecular exchange of the gas by the blood in the second oxygenation chamber may specifically be to control the oxygen partial pressure and the blood oxygen saturation in the blood by adjusting the oxygen concentration in the gas.
Accordingly, in fig. 5, the gas entering from the first gas inlet communicating with the upper cover may be subjected to gas flow rate adjustment by an additional member, and the partial pressure of carbon dioxide in blood may be controlled by adjusting the speed at which the gas flows in the hollow fiber tube.
The gas entering from the second gas inlet communicated with the middle connecting cover contains proper oxygen concentration, and the oxygen partial pressure and the blood oxygen saturation in blood are controlled by adjusting the oxygen concentration of the gas flowing in the hollow fiber tube.
When the double-cavity membrane oxygenator works, gas flow and blood flow are performed simultaneously.
The above described realizes the two complete gas exchange processes of blood in the double-cavity membrane oxygenator of the present example, and the specific gas flow mode is shown in fig. 5.
FIG. 7 is a schematic diagram of a second gas flow pattern in a dual-chamber membrane oxygenator according to an embodiment of the present invention, as shown in FIG. 7, wherein the gas flow pattern in FIG. 7 may be such that the dual-chamber membrane oxygenator of the present invention is used alone as an oxygenator or as a carbon dioxide remover.
The bolt switch arranged in the intermediate connecting cover and used for blocking or communicating the gas flowing in the first oxygenation chamber and the second oxygenation chamber is opened, namely the first oxygenation chamber and the gas flowing in the second oxygenation chamber are communicated, so that the independent two-layer structure in the intermediate connecting cover is communicated, namely the gas flows from the second gas inlet communicated with the intermediate connecting cover to the first gas outlet communicated with the intermediate connecting cover, and therefore the second gas inlet communicated with the intermediate connecting cover can be blocked, namely the gas enters from the first gas inlet of the upper cover and exits from the first gas outlet communicated with the intermediate connecting cover and the second gas outlet communicated with the lower cover respectively.
Specifically, the gas enters from the first air inlet communicated with the upper cover, is distributed over the whole upper cover for a circle, enters into the hollow fiber tube from the honeycomb-shaped blocking layer, flows into the middle connecting cover from the bottom end of the hollow fiber tube, is distributed over the middle connecting cover for a circle, one part of the gas exits from the first air outlet communicated with the middle connecting cover, and the other part of the gas continues to flow into the second oxygenation chamber, namely enters through the honeycomb-shaped blocking layer at the top end of the hollow fiber tube in the second oxygenation chamber, exits from the honeycomb-shaped blocking layer at the bottom of the hollow fiber tube, is distributed over the lower cover for a circle, and exits from the second air outlet communicated with the lower cover.
Here, when the gas entering from the first gas inlet communicated with the upper cover contains a proper amount of oxygen concentration, the dual-cavity membrane type oxygenator of the present invention can be used as an oxygenator alone; the dual-chamber membrane oxygenator of the present invention can be used alone as a carbon dioxide remover when gas entering from the first gas inlet communicated with the upper cover is passed through the hollow fiber tube by adjusting the flow rate of the gas.
When the first oxygenation chamber is not communicated with the gas flowing in the second oxygenation chamber and blood flows from bottom to top, a power pump is arranged on a blood inlet path interface communicated with the bottom end of the second oxygenation chamber to provide power for flowing from bottom to top, and correspondingly, a second gas inlet communicated with the middle connecting cover enters gas with a certain flow rate and a first gas inlet communicated with the upper cover enters gas with proper oxygen concentration and enters a hollow fiber tube through a blocking layer; blood enters an oxygen compression membrane formed by a plurality of hollow fiber tubes from a blood inlet channel interface communicated with the bottom end of the second oxygenation chamber, namely, the blood is fully distributed on the outer wall of the hollow fiber tubes, flows upwards through a lower mandrel side wall space communicated with the oxygen compression membrane after being exchanged with gas molecules flowing into the hollow fiber tubes, sequentially passes through a connecting shaft connected with the lower mandrel and an upper mandrel side wall space, then enters the first oxygenation chamber, is fully distributed on the outer wall of the hollow fiber tubes, and is discharged from a blood inlet channel interface arranged at the bottom of the first oxygenation chamber after being exchanged with the gas molecules flowing into the hollow fiber tubes; and gas entering from the second air inlet communicated with the middle connecting cover and the first air inlet communicated with the upper cover respectively goes out from the second air outlet communicated with the lower cover and the first air outlet communicated with the middle connecting cover.
When the gas flowing in the first oxygenation chamber and the second oxygenation chamber are not communicated and blood flows from top to bottom, the first gas inlet communicated with the upper cover correspondingly enters gas with a certain flow rate, the second gas inlet communicated with the middle connecting cover enters gas with proper oxygen concentration, and the gas enters the hollow fiber tube through the plugging layer; blood enters an oxygen compression membrane formed by a plurality of hollow fiber tubes from a blood inlet channel interface communicated with the bottom end of the first oxygenation chamber, namely, the blood is fully distributed on the outer wall of the hollow fiber tubes, flows downwards through an upper mandrel side wall space communicated with the oxygen compression membrane after being exchanged with gas molecules flowing into the hollow fiber tubes, sequentially passes through a connecting shaft connected with the upper mandrel and a lower mandrel side wall space, then enters the second oxygenation chamber, is fully distributed on the outer wall of the hollow fiber tubes, and is discharged from a blood inlet channel interface arranged at the bottom end of the second oxygenation chamber after being exchanged with the gas molecules flowing into the hollow fiber tubes; and gas entering from the first air inlet communicated with the upper cover and the second air inlet communicated with the middle connecting cover respectively goes out from the first air outlet communicated with the middle connecting cover and the second air outlet communicated with the lower cover.
When the gas flowing in the first oxygenation chamber and the second oxygenation chamber are communicated, blood flows from bottom to top or from top to bottom without being influenced by the communication of the gas flowing in the first oxygenation chamber and the gas flowing in the second oxygenation chamber, and when the gas entering from the first gas inlet communicated with the upper cover contains a proper oxygen concentration, the double-cavity membrane oxygenator can be independently used as an oxygenator; when the first air inlet communicated with the upper cover enters gas with a certain flow rate, the double-cavity membrane type oxygenator can be independently used as a carbon dioxide remover, and the process of being independently used as the oxygenator or the carbon dioxide remover is as follows;
when blood flows from bottom to top, the blood enters an oxygen compression film formed by a plurality of hollow fiber tubes from a blood inlet channel interface communicated with the bottom end of the second oxygenation chamber, namely, the blood is fully distributed on the outer wall of the hollow fiber tubes, flows upwards through a lower mandrel side wall space communicated with the oxygen compression film after being exchanged with gas molecules flowing into the hollow fiber tubes, sequentially passes through a connecting shaft connected with the lower mandrel and an upper mandrel side wall space, then enters the first oxygenation chamber, is fully distributed on the outer wall of the hollow fiber tubes, and is discharged from a blood inlet channel interface arranged at the bottom of the first oxygenation chamber after being exchanged with the gas molecules flowing into the hollow fiber tubes; and simultaneously, gas entering from a first gas inlet communicated with the upper cover is respectively discharged from a first gas outlet communicated with the middle connecting cover and a second gas outlet communicated with the lower cover.
When blood flows from top to bottom, the blood enters an oxygen compression film formed by a plurality of hollow fiber tubes from a blood inlet path interface communicated with the bottom end of the first oxygenation chamber, namely, the blood is fully distributed on the outer wall of the hollow fiber tubes, flows downwards through an upper mandrel side wall space communicated with the oxygen compression film after being exchanged with gas molecules flowing into the hollow fiber tubes, sequentially passes through a connecting shaft connected with the upper mandrel and a lower mandrel side wall space, then enters the second oxygenation chamber, is fully distributed on the outer wall of the hollow fiber tubes, and is discharged from a blood outlet path interface arranged at the bottom of the second oxygenation chamber after being exchanged with the gas molecules flowing into the hollow fiber tubes; and simultaneously, gas entering from a first gas inlet communicated with the upper cover is respectively discharged from a first gas outlet communicated with the middle connecting cover and a second gas outlet communicated with the lower cover.
And the second air inlet communicated with the middle connecting cover is plugged, namely, air enters from the first air inlet of the upper cover and goes out from the first air outlet communicated with the middle connecting cover and the second air outlet communicated with the lower cover respectively.
The specific types of the above-mentioned devices are not limited and described in detail, and the deep connection manner of the above-mentioned devices is not described in detail, as it is common knowledge, and it is understood by those skilled in the art.
The embodiment of the invention also provides a double-cavity membrane oxygenation method, and fig. 8 is a schematic diagram of a first flow chart of the double-cavity membrane oxygenation method according to the embodiment of the invention, and the method comprises the following steps:
step 801: after the blood exchanges gas through the first oxygenation chamber, the blood enters the upper mandrel side wall space and enters the lower mandrel side wall space through a connecting shaft which is communicated with the upper mandrel side wall space and the lower mandrel side wall space;
here, the first oxygenation chamber comprises a blocking layer and an oxygen pressing film, and is communicated with a blood inlet port; the upper mandrel is connected with the lower mandrel through a mandrel connecting block and is placed in the middle of the double-cavity membrane type oxygenator;
the oxygen compression film is composed of a plurality of hollow fiber pipes, the gas in the first oxygenation chamber flows in the hollow fiber pipes, blood is fully distributed on the outer walls of the hollow fiber pipes, and the blood oxygen content and the carbon dioxide content in the blood are realized through the gas flow rate and the oxygen concentration in the hollow fiber pipes;
here, the gas in the first oxygenation chamber may be a gas of a certain flow rate, so that the carbon dioxide content in the blood may be adjusted;
step 802: the blood enters the second oxygenation chamber from the lower mandrel side wall space, and is discharged after gas exchange is carried out again;
the second oxygenation chamber comprises a blocking layer and an oxygen pressing film and is communicated with a bleeding path interface;
the oxygen pressing film is composed of a plurality of hollow fiber pipes, the gas in the second oxygenation chamber flows in the hollow fiber pipes, the blood is fully distributed on the outer walls of the hollow fiber pipes, and the blood oxygen content and the carbon dioxide content in the blood are realized through the gas flow rate and the oxygen concentration in the hollow fiber pipes;
here, the gas in the second oxygenation chamber may be a gas containing an appropriate oxygen concentration, so that the blood oxygen content in the blood can be adjusted;
further, the method further comprises: the gas in the first oxygenation chamber and the gas in the second oxygenation chamber may not be communicated or intercommunicated;
here, the first oxygenation chamber and the second oxygenation chamber are connected through an intermediate connection cover, and a bolt switch for blocking or communicating gas circulation in the first oxygenation chamber and the second oxygenation chamber is arranged in the intermediate connection cover;
when the gas in the first oxygenation chamber is not communicated with the gas in the second oxygenation chamber, the gas in the first oxygenation chamber and the gas in the second oxygenation chamber can be different gases, for example, the first oxygenation chamber is filled with an air-oxygen mixed gas with the oxygen concentration of 66%, the oxygen partial pressure and the blood oxygen saturation in blood are improved to the clinical requirements of operation, and the second oxygenation chamber is filled with air to remove excessive carbon dioxide in blood, so that the main purpose is to improve the oxygenation efficiency of the blood when the oxygen exchange is carried out, namely, the carbon dioxide content in the blood can be effectively adjusted, and the blood oxygen content in the blood can be effectively adjusted;
when the gas in the first oxygenation chamber is communicated with the gas in the second oxygenation chamber, the gas can be used as an oxygenator alone or as a carbon dioxide remover alone;
here, the procedure used alone as an oxygenator or as a carbon dioxide remover is as follows:
when blood flows from top to bottom, the blood enters an oxygen compression film formed by a plurality of hollow fiber tubes from a blood inlet port communicated with the bottom end of the first oxygenation chamber, namely, the blood is fully distributed on the outer wall of the hollow fiber tubes, flows downwards through an upper mandrel side wall space communicated with the oxygen compression film after being exchanged with gas molecules flowing into the hollow fiber tubes, sequentially passes through a connecting shaft connected with the upper mandrel and a lower mandrel side wall space, then enters the second oxygenation chamber, is fully distributed on the outer wall of the hollow fiber tubes, and is removed from a blood outlet port arranged at the bottom of the second oxygenation chamber after being exchanged with gas molecules flowing into the hollow fiber tubes; and simultaneously, gas entering from a first gas inlet communicated with the upper cover is respectively discharged from a second gas outlet communicated with the middle connecting cover and a first gas outlet communicated with the lower cover.
The embodiment of the invention further provides a double-cavity membrane type oxygenation method, and fig. 9 is a second flow chart of the double-cavity membrane type oxygenation method according to the embodiment of the invention, and the method comprises the following steps:
step 901: after the blood exchanges gas through the second oxygenation chamber, the blood enters the lower mandrel side wall space and enters the upper mandrel side wall space through a connecting shaft which is communicated with the lower mandrel side wall space and the upper mandrel side wall space;
the second oxygenation chamber comprises a blocking layer and an oxygen pressing film and is communicated with a blood inlet port; the lower mandrel is connected with the upper mandrel through a mandrel connecting block and is placed in the middle of the double-cavity membrane type oxygenator;
here, when the bottom of the second oxygenation chamber is communicated with the blood inlet port, a power pump is arranged on the blood inlet port communicated with the bottom of the second oxygenation chamber to provide the power for the blood to flow from bottom to top.
The oxygen pressing film is composed of a plurality of hollow fiber pipes, the gas in the second oxygenation chamber flows in the hollow fiber pipes, the blood is fully distributed on the outer walls of the hollow fiber pipes, and the blood oxygen content and the carbon dioxide content in the blood are realized through the gas flow rate and the oxygen concentration in the hollow fiber pipes;
here, the gas in the second oxygenation chamber may be a gas of a certain flow rate, so that the carbon dioxide content in the blood may be adjusted;
step 902: the blood enters the first oxygenation chamber from the side wall space of the upper mandrel, and is discharged after gas exchange is carried out again;
here, the first oxygenation chamber comprises a blocking layer and an oxygen pressing film and is communicated with a bleeding path interface;
the oxygen compression film is composed of a plurality of hollow fiber pipes, the gas in the first oxygenation chamber flows in the hollow fiber pipes, blood is fully distributed on the outer walls of the hollow fiber pipes, and the blood oxygen content and the carbon dioxide content in the blood are realized through the gas flow rate and the oxygen concentration in the hollow fiber pipes;
here, the gas in the first oxygenation chamber may be a gas containing an appropriate amount of oxygen concentration, so that the blood oxygen content in the blood may be adjusted;
further, the method further comprises: the gas in the second oxygenation chamber and the gas in the first oxygenation chamber may not be communicated or intercommunicated;
here, the second oxygenation chamber is connected with the first oxygenation chamber through an intermediate connection cover, and a bolt switch for blocking or communicating the second oxygenation chamber with the first oxygenation chamber is arranged in the intermediate connection cover;
when the gas in the first oxygenation chamber is not communicated with the gas in the second oxygenation chamber, the gas in the first oxygenation chamber and the gas in the second oxygenation chamber can be different gases, for example, the first oxygenation chamber is filled with an air-oxygen mixed gas with the oxygen concentration of 66%, the oxygen partial pressure and the blood oxygen saturation in blood are improved to the clinical requirements of operation, and the second oxygenation chamber is filled with air to remove excessive carbon dioxide in the blood, so that the oxygenation efficiency of the blood in oxygen exchange is improved, the carbon dioxide content in the blood can be effectively adjusted, and the blood oxygen content in the blood can be effectively adjusted;
when the gas in the first oxygenation chamber is communicated with the gas in the second oxygenation chamber, the gas can be used as an oxygenator alone or as a carbon dioxide remover alone;
the process of using the catalyst as an oxygenator alone or as a carbon dioxide remover alone is as follows:
when blood flows from bottom to top, the blood enters an oxygen compression film formed by a plurality of hollow fiber tubes from a blood inlet path interface communicated with the bottom end of the second oxygenation chamber, namely, the blood is fully distributed on the outer wall of the hollow fiber tubes, flows upwards through a lower mandrel side wall space communicated with the oxygen compression film after being exchanged with gas molecules flowing into the hollow fiber tubes, sequentially passes through a connecting shaft connected with the lower mandrel and an upper mandrel side wall space, then enters the first oxygenation chamber, is fully distributed on the outer wall of the hollow fiber tubes, and is discharged from a blood outlet path interface arranged at the bottom of the first oxygenation chamber after being exchanged with the gas molecules flowing into the hollow fiber tubes; and simultaneously, gas entering from a first gas inlet communicated with the upper cover is respectively discharged from a second gas outlet communicated with the middle connecting cover and a first gas outlet communicated with the lower cover.
The specific types of the above-mentioned devices are not limited and described in detail, and the deep connection manner of the above-mentioned devices is not described in detail, as it is common knowledge, and it is understood by those skilled in the art.
The embodiments of the present invention are merely presented to describe specific embodiments thereof, and are not intended to limit the scope of protection thereof. Certain modifications may be made by those skilled in the art in light of the teachings of this embodiment, and all equivalent changes and modifications that come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Claims (8)
1. The double-cavity membrane type oxygenator comprises an upper cover and a lower cover, and is characterized by further comprising a middle connecting cover, a mandrel structure, a first oxygenation chamber and a second oxygenation chamber; the first oxygenation chamber and the second oxygenation chamber comprise an oxygen pressing film and blocking layers arranged at the top and the bottom of the oxygen pressing film, and are respectively communicated with a blood path interface; the mandrel structure comprises an upper mandrel, a lower mandrel and a mandrel connecting block for connecting the upper mandrel and the lower mandrel, wherein the upper mandrel is communicated with the lower mandrel side wall space through a connecting shaft, and the upper mandrel side wall space and the lower mandrel side wall space are both communicated with the oxygen film pressing gap; the middle of the upper mandrel is of a solid structure, the side wall forms a space, and a gap through which blood passes is formed on one side contacted with the oxygen film pressing gap; the upper cover, the middle connecting cover and the lower cover are communicated with an air port; the top and the bottom of the first oxygenation chamber are respectively connected with the upper cover and the middle connecting cover; the top and the bottom of the second oxygenation chamber are respectively connected with the middle connecting cover and the lower cover; a bolt switch for blocking or communicating the gas circulation in the first oxygenation chamber and the second oxygenation chamber is arranged in the middle connecting cover; the first oxygenation chamber and the second oxygenation chamber are respectively communicated with a blood path interface, and the blood path interface comprises: the bottom of the first oxygenation chamber is communicated with a blood path connector, and the bottom of the second oxygenation chamber is communicated with a blood path connector; or the bottom of the first oxygenation chamber is communicated with the blood inlet port, and the bottom of the second oxygenation chamber is communicated with the blood outlet port.
2. The dual chamber membrane oxygenator as claimed in claim 1, wherein said oxygen compression membrane is comprised of hollow fiber tubes and said plugging layer is of a honeycomb structure.
3. A dual lumen membrane oxygenator as claimed in claim 2 wherein said plugging layer of honeycomb structure is in registry with said hollow fiber tube orifice.
4. The dual chamber membrane oxygenator as claimed in claim 1 wherein said upper cover is in communication with a first air inlet, said intermediate connecting cover is in communication with a first air outlet, a second air inlet, and said lower cover is in communication with a second air outlet.
5. A method of double-lumen membrane oxygenation using the double-lumen membrane oxygenator of claim 1, wherein the method of operation when blood flows from top to bottom comprises:
s1: after the blood exchanges gas through the first oxygenation chamber, the blood enters the upper mandrel side wall space and enters the lower mandrel side wall space through a connecting shaft which is communicated with the upper mandrel side wall space and the lower mandrel side wall space;
s2: the blood enters the second oxygenation chamber from the side wall space of the lower mandrel to exchange gas again and then is discharged;
s3: the procedure used alone as an oxygenator or as a carbon dioxide remover was as follows: when blood flows from top to bottom, the blood enters an oxygen compression film formed by a plurality of hollow fiber tubes from a blood inlet port communicated with the bottom end of a first oxygenation chamber, namely, the blood is fully distributed on the outer wall of the hollow fiber tubes, flows downwards through an upper mandrel side wall space communicated with the oxygen compression film after being exchanged with gas molecules flowing into the hollow fiber tubes, sequentially passes through a connecting shaft connected with the upper mandrel side wall space and a lower mandrel side wall space and then enters a second oxygenation chamber, and is fully distributed on the outer wall of the hollow fiber tubes, and the blood is discharged from a blood inlet port arranged at the bottom of the second oxygenation chamber after being exchanged with the gas molecules flowing into the hollow fiber tubes; and simultaneously, gas entering from a first air inlet communicated with the upper cover is respectively discharged from a second air outlet communicated with the middle connecting cover and a first air outlet communicated with the lower cover.
6. A dual chamber membrane oxygenation process according to claim 5, wherein the process further comprises: the gas in the first oxygenation chamber and the gas in the second oxygenation chamber may not be communicated or intercommunicated.
7. A method of double-lumen membrane oxygenation according to claim 1, wherein the method of operation when blood flows from bottom to top comprises:
s1: after the blood exchanges gas through the second oxygenation chamber, the blood enters the lower mandrel side wall space and enters the upper mandrel side wall space through a connecting shaft which is communicated with the lower mandrel side wall space and the upper mandrel side wall space;
s2: the blood enters the first oxygenation chamber from the side wall space of the upper mandrel to exchange gas again and then is discharged:
s3: the process of using the catalyst as an oxygenator alone or as a carbon dioxide remover alone is as follows: when blood flows from bottom to top, the blood enters an oxygen compression film formed by a plurality of hollow fiber tubes from a blood inlet port communicated with the bottom end of the second oxygenation chamber, namely, the blood is fully distributed on the outer wall of the hollow fiber tubes, flows upwards through a lower mandrel side wall space communicated with the oxygen compression film after being exchanged with gas molecules flowing into the hollow fiber tubes, sequentially passes through a connecting shaft connected with the lower mandrel and an upper mandrel side wall space, then enters a first oxygenation chamber, and is fully distributed on the outer wall of the hollow fiber tubes, and the blood is discharged from a blood outlet port arranged at the bottom of the first oxygenation chamber after being exchanged with the gas molecules flowing into the hollow fiber tubes; and simultaneously, gas entering from a first air inlet communicated with the upper cover is respectively discharged from a second air outlet communicated with the middle connecting cover and a first air outlet communicated with the lower cover.
8. A dual chamber membrane oxygenation process according to claim 7, wherein the process further comprises: the gas in the second oxygenation chamber may not be in communication or in communication with the gas in the first oxygenation chamber.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811493014.6A CN109364314B (en) | 2018-12-07 | 2018-12-07 | Double-cavity membrane type oxygenator and oxygenation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811493014.6A CN109364314B (en) | 2018-12-07 | 2018-12-07 | Double-cavity membrane type oxygenator and oxygenation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109364314A CN109364314A (en) | 2019-02-22 |
| CN109364314B true CN109364314B (en) | 2023-10-24 |
Family
ID=65376593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811493014.6A Active CN109364314B (en) | 2018-12-07 | 2018-12-07 | Double-cavity membrane type oxygenator and oxygenation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109364314B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109364315A (en) * | 2018-12-07 | 2019-02-22 | 江苏美思康医疗科技有限公司 | A kind of band alternating temperature two-chamber membrane oxygenator |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0089122A2 (en) * | 1982-02-19 | 1983-09-21 | CD Medical, Inc. | Hollow fibre oxygenator, assembly containing same and method for making same |
| CA2229843A1 (en) * | 1995-09-01 | 1997-03-13 | Edwards Lifesciences Corporation | Hollow fiber oxygenator |
| CN2277783Y (en) * | 1996-06-27 | 1998-04-08 | 西安西京医疗用品有限公司 | Nembrane type oxyenator |
| CN2452502Y (en) * | 2000-12-22 | 2001-10-10 | 戴刚 | Before pump and lower part blood drainage tyhpe hollow fiber film oxygenation device |
| CN201510571U (en) * | 2009-09-29 | 2010-06-23 | 山东威高新生医疗器械有限公司 | Membrane type oxygenator |
| CN203663149U (en) * | 2014-01-08 | 2014-06-25 | 陈樱 | Membrane oxygenator |
| CN107929839A (en) * | 2018-01-16 | 2018-04-20 | 王辉山 | A kind of portable membrane oxygenator and preparation method and its oxygen close method |
| CN209286304U (en) * | 2018-12-07 | 2019-08-23 | 江苏美思康医疗科技有限公司 | A kind of two-chamber membrane oxygenator |
-
2018
- 2018-12-07 CN CN201811493014.6A patent/CN109364314B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0089122A2 (en) * | 1982-02-19 | 1983-09-21 | CD Medical, Inc. | Hollow fibre oxygenator, assembly containing same and method for making same |
| CA2229843A1 (en) * | 1995-09-01 | 1997-03-13 | Edwards Lifesciences Corporation | Hollow fiber oxygenator |
| CN2277783Y (en) * | 1996-06-27 | 1998-04-08 | 西安西京医疗用品有限公司 | Nembrane type oxyenator |
| CN2452502Y (en) * | 2000-12-22 | 2001-10-10 | 戴刚 | Before pump and lower part blood drainage tyhpe hollow fiber film oxygenation device |
| CN201510571U (en) * | 2009-09-29 | 2010-06-23 | 山东威高新生医疗器械有限公司 | Membrane type oxygenator |
| CN203663149U (en) * | 2014-01-08 | 2014-06-25 | 陈樱 | Membrane oxygenator |
| CN107929839A (en) * | 2018-01-16 | 2018-04-20 | 王辉山 | A kind of portable membrane oxygenator and preparation method and its oxygen close method |
| CN209286304U (en) * | 2018-12-07 | 2019-08-23 | 江苏美思康医疗科技有限公司 | A kind of two-chamber membrane oxygenator |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109364314A (en) | 2019-02-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7393327B2 (en) | Dual chamber gas exchanger for breathing assistance and how to use it | |
| US20200276377A1 (en) | Blood gas exchanger with restriction element or elements to reduce gas exchange | |
| US10610629B2 (en) | Device with inlet portion for treating a biological liquid | |
| JP4036828B2 (en) | Hemodialysis machine with improved dialysate perfusion | |
| US4176069A (en) | Device for exchanging substances and method of manufacturing the device | |
| US9095817B2 (en) | Device for the treatment of biological fluid | |
| US20070119781A1 (en) | Apparatus and method for enhanced hemodialysis performance | |
| EP1557185B1 (en) | Device for treating blood for extracorporeal circulation | |
| CN107929839A (en) | A kind of portable membrane oxygenator and preparation method and its oxygen close method | |
| CN113509605B (en) | Membrane oxygenator | |
| CN109364314B (en) | Double-cavity membrane type oxygenator and oxygenation method | |
| CN201192486Y (en) | Oxygenation chamber structure of film oxygenator | |
| CN115192807A (en) | Oxygenator and extracorporeal membrane lung oxygenating device | |
| US9408960B2 (en) | Partial radial heat exchanger and oxygenator | |
| EP3600484B1 (en) | Oxygenator of organic fluids | |
| CN107405437B (en) | Mass exchange device and method of use | |
| KR101762228B1 (en) | A blood oxygenator | |
| CA3158571A1 (en) | A working fluid treatment device for mass transfer between a working fluid and two fluid exchange media | |
| JPH0371A (en) | Fluid treating device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |