CN107922393A - 携带非芳族p2,基团的因子xia新大环 - Google Patents

携带非芳族p2,基团的因子xia新大环 Download PDF

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Publication number
CN107922393A
CN107922393A CN201680044102.0A CN201680044102A CN107922393A CN 107922393 A CN107922393 A CN 107922393A CN 201680044102 A CN201680044102 A CN 201680044102A CN 107922393 A CN107922393 A CN 107922393A
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China
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occurrence
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CN201680044102.0A
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English (en)
Chinese (zh)
Inventor
朱晔恒
A.K.迪尔格
W.R.尤因
M.J.奥尔沃特
D.J.P.平托
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Priority to CN202210443120.3A priority Critical patent/CN114805365B/zh
Priority to CN202210447302.8A priority patent/CN114874222B/zh
Publication of CN107922393A publication Critical patent/CN107922393A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN201680044102.0A 2015-07-29 2016-07-28 携带非芳族p2,基团的因子xia新大环 Pending CN107922393A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202210443120.3A CN114805365B (zh) 2015-07-29 2016-07-28 携带非芳族p2′基团的因子xia新大环
CN202210447302.8A CN114874222B (zh) 2015-07-29 2016-07-28 携带非芳族p2,基团的因子xia新大环

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562198188P 2015-07-29 2015-07-29
US62/198188 2015-07-29
PCT/US2016/044363 WO2017019821A1 (en) 2015-07-29 2016-07-28 Factor xia new macrocycle bearing a non-aromatic p2' group

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN202210443120.3A Division CN114805365B (zh) 2015-07-29 2016-07-28 携带非芳族p2′基团的因子xia新大环
CN202210447302.8A Division CN114874222B (zh) 2015-07-29 2016-07-28 携带非芳族p2,基团的因子xia新大环

Publications (1)

Publication Number Publication Date
CN107922393A true CN107922393A (zh) 2018-04-17

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
CN202210447302.8A Active CN114874222B (zh) 2015-07-29 2016-07-28 携带非芳族p2,基团的因子xia新大环
CN202210443120.3A Active CN114805365B (zh) 2015-07-29 2016-07-28 携带非芳族p2′基团的因子xia新大环
CN201680044102.0A Pending CN107922393A (zh) 2015-07-29 2016-07-28 携带非芳族p2,基团的因子xia新大环

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CN202210447302.8A Active CN114874222B (zh) 2015-07-29 2016-07-28 携带非芳族p2,基团的因子xia新大环
CN202210443120.3A Active CN114805365B (zh) 2015-07-29 2016-07-28 携带非芳族p2′基团的因子xia新大环

Country Status (7)

Country Link
US (1) US10676477B2 (enExample)
EP (2) EP3328852B1 (enExample)
JP (1) JP6816103B2 (enExample)
KR (1) KR102729666B1 (enExample)
CN (3) CN114874222B (enExample)
ES (2) ES2871111T3 (enExample)
WO (1) WO2017019821A1 (enExample)

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US9453018B2 (en) * 2014-10-01 2016-09-27 Bristol-Myers Squibb Company Pyrimidinones as factor XIa inhibitors
EP3310777B1 (en) 2015-06-19 2019-10-09 Bristol-Myers Squibb Company Diamide macrocycles as factor xia inhibitors
CN107849026B (zh) 2015-07-29 2021-01-01 百时美施贵宝公司 携带烷基或环烷基p2′部分的因子xia大环抑制剂
EP3423458A1 (en) 2016-03-02 2019-01-09 Bristol-Myers Squibb Company Diamide macrocycles having factor xia inhibiting activity
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

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CN102753555A (zh) * 2010-02-11 2012-10-24 百时美施贵宝公司 作为因子xia抑制剂的大环类
CN104507924A (zh) * 2012-08-03 2015-04-08 百时美施贵宝公司 二氢吡啶酮p1作为凝血因子xia抑制剂

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CN102753555A (zh) * 2010-02-11 2012-10-24 百时美施贵宝公司 作为因子xia抑制剂的大环类
CN104507924A (zh) * 2012-08-03 2015-04-08 百时美施贵宝公司 二氢吡啶酮p1作为凝血因子xia抑制剂

Also Published As

Publication number Publication date
CN114874222A (zh) 2022-08-09
KR102729666B1 (ko) 2024-11-12
ES2937156T3 (es) 2023-03-24
US20190010154A1 (en) 2019-01-10
JP6816103B2 (ja) 2021-01-20
US10676477B2 (en) 2020-06-09
JP2018522024A (ja) 2018-08-09
EP3868753A1 (en) 2021-08-25
CN114874222B (zh) 2025-06-06
CN114805365A (zh) 2022-07-29
CN114805365B (zh) 2024-07-23
EP3328852A1 (en) 2018-06-06
KR20180033267A (ko) 2018-04-02
WO2017019821A1 (en) 2017-02-02
ES2871111T3 (es) 2021-10-28
EP3328852B1 (en) 2021-04-28
EP3868753B1 (en) 2022-12-21

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Application publication date: 20180417