CN107922345B - 作为碳酸酐酶抑制剂的芳基磺酰胺化合物及其治疗用途 - Google Patents
作为碳酸酐酶抑制剂的芳基磺酰胺化合物及其治疗用途 Download PDFInfo
- Publication number
- CN107922345B CN107922345B CN201680046227.7A CN201680046227A CN107922345B CN 107922345 B CN107922345 B CN 107922345B CN 201680046227 A CN201680046227 A CN 201680046227A CN 107922345 B CN107922345 B CN 107922345B
- Authority
- CN
- China
- Prior art keywords
- benzenesulfonamide
- oxoimidazolidin
- cancer
- amino
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562187636P | 2015-07-01 | 2015-07-01 | |
| US62/187,636 | 2015-07-01 | ||
| PCT/US2016/040736 WO2017004543A1 (en) | 2015-07-01 | 2016-07-01 | Aryl sulfonamide compounds as carbonic anhydrase inhibitors and their therapeutic use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107922345A CN107922345A (zh) | 2018-04-17 |
| CN107922345B true CN107922345B (zh) | 2021-03-23 |
Family
ID=56411955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680046227.7A Active CN107922345B (zh) | 2015-07-01 | 2016-07-01 | 作为碳酸酐酶抑制剂的芳基磺酰胺化合物及其治疗用途 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10562859B2 (OSRAM) |
| EP (1) | EP3317255B1 (OSRAM) |
| JP (1) | JP6795525B2 (OSRAM) |
| KR (1) | KR102637759B1 (OSRAM) |
| CN (1) | CN107922345B (OSRAM) |
| AU (1) | AU2016287587B2 (OSRAM) |
| BR (1) | BR112018000065B1 (OSRAM) |
| CA (1) | CA2991168C (OSRAM) |
| IL (1) | IL256527B (OSRAM) |
| MX (1) | MX387267B (OSRAM) |
| WO (1) | WO2017004543A1 (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102836514B1 (ko) * | 2017-04-05 | 2025-07-22 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 마크로시클릭 화합물 및 그의 용도 |
| KR20210000564A (ko) | 2019-06-25 | 2021-01-05 | 공주대학교 산학협력단 | 신규 아만타딘 유도체 화합물 및 이의 용도 |
| CN111233786B (zh) * | 2020-02-04 | 2021-11-26 | 中国人民解放军军事科学院军事医学研究院 | 含五元杂环的苯磺酰胺类化合物及其制备方法和用途 |
| ES3014428T3 (en) * | 2020-06-02 | 2025-04-22 | Univ Yeditepe | 2-(3-(2-methyl-6-(p-tolyl) pyridine-3-yl) ureido) benzenesulfonamide and derivatives as inhibitor of carbonic anhydrase ix for the treatment of cancer |
| TR202014185A2 (tr) * | 2020-09-08 | 2022-03-21 | Anadolu Ueniversitesi | BAZI YENİ 4-(2-((5-(SÜBSTİTÜEAMİNO)-1,3,4-TİYADİAZOL-2-İL)TİYO)ASETİL)BENZENSÜLFONAMİD TÜREVLERİ ve SÖZ KONUSU TÜREVLERİN SENTEZİ İÇİN BİR YÖNTEM |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003013655A2 (en) * | 2001-08-10 | 2003-02-20 | Pharmacia Corporation | Carbonic anhydrase inhibitors |
| CN101610761A (zh) * | 2006-12-22 | 2009-12-23 | 诺瓦提斯公司 | 作为ddp-iv抑制剂的1-氨基甲基-l-苯基-环己烷衍生物 |
| WO2013023274A1 (en) * | 2011-08-16 | 2013-02-21 | Universite Laval | Substituted 2-imidazolidinones and 2-imidazolones and their use in the treatment of cancer |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2628459T3 (es) | 2010-07-09 | 2017-08-02 | Welichem Biotech Inc. | Compuestos novedosos de sulfonamida para la inhibición del crecimiento de tumores metastásicos |
-
2016
- 2016-07-01 MX MX2018000175A patent/MX387267B/es unknown
- 2016-07-01 KR KR1020187003119A patent/KR102637759B1/ko active Active
- 2016-07-01 CA CA2991168A patent/CA2991168C/en active Active
- 2016-07-01 AU AU2016287587A patent/AU2016287587B2/en active Active
- 2016-07-01 WO PCT/US2016/040736 patent/WO2017004543A1/en not_active Ceased
- 2016-07-01 BR BR112018000065-5A patent/BR112018000065B1/pt active IP Right Grant
- 2016-07-01 US US15/743,601 patent/US10562859B2/en active Active
- 2016-07-01 EP EP16738988.1A patent/EP3317255B1/en active Active
- 2016-07-01 CN CN201680046227.7A patent/CN107922345B/zh active Active
- 2016-07-01 JP JP2017568244A patent/JP6795525B2/ja active Active
-
2017
- 2017-12-24 IL IL256527A patent/IL256527B/en active IP Right Grant
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003013655A2 (en) * | 2001-08-10 | 2003-02-20 | Pharmacia Corporation | Carbonic anhydrase inhibitors |
| CN101610761A (zh) * | 2006-12-22 | 2009-12-23 | 诺瓦提斯公司 | 作为ddp-iv抑制剂的1-氨基甲基-l-苯基-环己烷衍生物 |
| WO2013023274A1 (en) * | 2011-08-16 | 2013-02-21 | Universite Laval | Substituted 2-imidazolidinones and 2-imidazolones and their use in the treatment of cancer |
Non-Patent Citations (4)
| Title |
|---|
| 4-Amino-substituted Benzenesulfonamides as Inhibitors of Human Carbonic Anhydrases;Kestutis Rutkauskas et al.;《Molecules》;20141028;第19卷;第17356-17380页 * |
| Carbonic anhydrase inhibitors: Inhibition of the tumor-associated isozymes IX and XII with polyfluorinated aromatic/heterocyclic sulfonamides;Silvia Pastorekova et al.;《Journal of Enzyme Inhibition and Medicinal Chemistry》;20050630;第20卷(第3期);全文 * |
| Synthesis and carbonic anhydrase I, II, IX and XII inhibition studies of 4-N,N-disubstituted sulfanilamides incorporating 4,4,4-trifluoro-3-oxo-but-1-enyl, phenacylthiourea and imidazol-2(3H)-one/thione Moieties;Cenzo Congiu et al.;《Bioorganic & Medicinal Chemistry Letters》;20140221;第24卷;第1777页左栏第3段、Scheme 1，第1778页Table 1 * |
| Ureido-Substituted Benzenesulfonamides Potently Inhibit Carbonic Anhydrase IX and Show Antimetastatic Activity in a Model of Breast Cancer Metastasis;Fabio Pacchiano et al.;《Journal of Medicinal Chemistry》;20110301;第54卷;第1898页Table 1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR102637759B1 (ko) | 2024-02-19 |
| JP2018519332A (ja) | 2018-07-19 |
| US10562859B2 (en) | 2020-02-18 |
| WO2017004543A1 (en) | 2017-01-05 |
| IL256527A (en) | 2018-02-28 |
| MX2018000175A (es) | 2018-03-26 |
| BR112018000065B1 (pt) | 2023-11-07 |
| HK1248228A1 (en) | 2018-10-12 |
| MX387267B (es) | 2025-03-18 |
| KR20180023990A (ko) | 2018-03-07 |
| CA2991168A1 (en) | 2017-01-05 |
| EP3317255B1 (en) | 2021-09-01 |
| AU2016287587A1 (en) | 2018-01-25 |
| AU2016287587B2 (en) | 2020-04-30 |
| CA2991168C (en) | 2022-04-26 |
| BR112018000065A2 (pt) | 2018-09-11 |
| IL256527B (en) | 2021-04-29 |
| EP3317255A1 (en) | 2018-05-09 |
| CN107922345A (zh) | 2018-04-17 |
| JP6795525B2 (ja) | 2020-12-02 |
| US20180201584A1 (en) | 2018-07-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |