CN107922329A - 用于制备水溶性紫杉烷类衍生物的方法及中间体 - Google Patents

用于制备水溶性紫杉烷类衍生物的方法及中间体 Download PDF

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Publication number
CN107922329A
CN107922329A CN201680047282.8A CN201680047282A CN107922329A CN 107922329 A CN107922329 A CN 107922329A CN 201680047282 A CN201680047282 A CN 201680047282A CN 107922329 A CN107922329 A CN 107922329A
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China
Prior art keywords
acid
compound
formula
allyloxycarbonyl
benzyloxycarbonyl group
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CN201680047282.8A
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English (en)
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CN107922329B (zh
Inventor
李勤耕
王涛
陈刚
夏彪
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Jiangsu Nhwaluokang Pharmceutical Research And Development Co ltd
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Jiangsu Nhwaluokang Pharmceutical Research And Development Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN201680047282.8A 2015-08-14 2016-08-15 用于制备水溶性紫杉烷类衍生物的方法及中间体 Active CN107922329B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201510502909 2015-08-14
CN2015105029091 2015-08-14
PCT/CN2016/095278 WO2017028766A1 (zh) 2015-08-14 2016-08-15 用于制备水溶性紫杉烷类衍生物的方法及中间体

Publications (2)

Publication Number Publication Date
CN107922329A true CN107922329A (zh) 2018-04-17
CN107922329B CN107922329B (zh) 2020-11-24

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CN (1) CN107922329B (zh)
WO (1) WO2017028766A1 (zh)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1709516A (zh) * 2005-05-31 2005-12-21 赵洪 高水溶性前体药物及其制备方法和在制药中的应用
CN101563333A (zh) * 2006-12-18 2009-10-21 韩美药品株式会社 制备紫杉烷衍生物的方法及其中所用的中间体
CN101648973A (zh) * 2009-09-03 2010-02-17 漆又毛 水溶性紫杉烷及制备方法
US20100093935A1 (en) * 2008-10-15 2010-04-15 Nitto Denko Corporation Method of preparing polyglutamate conjugates
CN101935336A (zh) * 2010-09-01 2011-01-05 北京大学 一类水溶性紫杉烷类药物的制备方法和应用
CN104693252A (zh) * 2013-12-05 2015-06-10 中国科学院上海药物研究所 糖苷化紫杉烷类化合物及其制备方法
WO2015120822A1 (zh) * 2014-02-17 2015-08-20 江苏恩华络康药物研发有限公司 一类水溶性紫杉烷类衍生物及其用途

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1709516A (zh) * 2005-05-31 2005-12-21 赵洪 高水溶性前体药物及其制备方法和在制药中的应用
CN101563333A (zh) * 2006-12-18 2009-10-21 韩美药品株式会社 制备紫杉烷衍生物的方法及其中所用的中间体
US20100093935A1 (en) * 2008-10-15 2010-04-15 Nitto Denko Corporation Method of preparing polyglutamate conjugates
CN101648973A (zh) * 2009-09-03 2010-02-17 漆又毛 水溶性紫杉烷及制备方法
CN101935336A (zh) * 2010-09-01 2011-01-05 北京大学 一类水溶性紫杉烷类药物的制备方法和应用
CN104693252A (zh) * 2013-12-05 2015-06-10 中国科学院上海药物研究所 糖苷化紫杉烷类化合物及其制备方法
WO2015120822A1 (zh) * 2014-02-17 2015-08-20 江苏恩华络康药物研发有限公司 一类水溶性紫杉烷类衍生物及其用途

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
徐少杰,等.: "多西他赛合成工艺", 《科技导报》 *
蒲俊勇.: "紫杉烷类水溶性前药的设计与合成", 《中国优秀硕士学位论文全文数据库·医药卫生科技辑》 *
陈明.: "新型紫杉烷类衍生物的设计、合成及抗肿瘤活性研究", 《中国博士学位论文全文数据库·医药卫生科技辑》 *

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Publication number Publication date
CN107922329B (zh) 2020-11-24
WO2017028766A1 (zh) 2017-02-23

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