CN107898730A

CN107898730A - A kind of pouch maintenance elite composition containing polypeptide

Info

Publication number: CN107898730A
Application number: CN201711425861.4A
Authority: CN
Inventors: 沈华忠
Original assignee: Jane (guangzhou) Cosmetics Co Ltd
Current assignee: Jane (guangzhou) Cosmetics Co Ltd
Priority date: 2017-12-26
Filing date: 2017-12-26
Publication date: 2018-04-13

Abstract

The present invention provides a kind of pouch maintenance elite composition containing polypeptide, and compared with prior art, the present invention has following beneficial effect：It can delay eye skin aging, improve edema and livid ring around eye, anti-Hemostatic Oral Liquid is detained eye circumference, round-the-clock intensive moisturizing.Improve eye circumference skin water shortage phenomenon, make eye circumference skin moment water profit flexible, so as to avoid the generation of dry line microgroove.

Description

A kind of pouch maintenance elite composition containing polypeptide

Technical field

The present invention is a kind of pouch maintenance elite composition containing polypeptide, belongs to cosmetic technical field.

Background technology

More and more researchs show that the maintenance problem of eye skin is very important, if maintenance is improper, easily accelerate skin old Change, easily relax, the eye circumference problem such as dry, dim heavy, microgroove, livid ring around eye, edema.Eye cream as skin type cosmetic product it One, there is moist eyelet skin.In addition to the problem of can lowering livid ring around eye, pouch, while also possess and improve wrinkle, thin The effect of line.Eye cream is around protect eyes than this layer of relatively thin skin, to pouch, livid ring around eye, crow's feet etc. all There is certain effectiveness, but different eye creams plays the role of different, is functionally divided into moist eye cream, consolidation eye cream, anti-aging Eye cream, antiallergic eye cream etc..It is with strong points due to eye cream, it is safe to use not stimulate skin, can frequently it use, it has also become skin care item Increasingly it is active in market the category of status.And existing eye cream, also in the unexpected winner area of exploitation, and such product is big The effect of most eye creams, is single, is unable to reach multiple-effect function, and the multiple skin care products that need to arrange in pairs or groups use, complex steps.

Therefore, developing a kind of eye cream with multiple-effect just has highly important meaning.

The content of the invention

In view of the deficienciess of the prior art, it is an object of the present invention to provide a kind of pouch maintenance elite combination containing polypeptide Thing, to solve the problems mentioned in the above background technology.

To achieve these goals, the present invention is to realize by the following technical solutions：A kind of pouch containing polypeptide is repaiied Elite composition is protected, is made of following raw material：Water, ring five dimethyl silicone polymer, glycerine, aurantiamarin methyl chalcone, tristearin Alcohol polyethers -20, sodium citrate, chlorhexidine digluconate, palmitoyl oligopeptide, potassium sorbate, citric acid, Matrixyl -4, Dimethyl silicone polymer, ring five dimethyl silicone polymer, trideceth -6, stearine, 1,2- hexylene glycols, nicotinoyl Amine, hydrogenation C6-14 polymerization of olefins species, dimethyl silicone polymer, cetanol, glycine betaine, butanediol, C12-13 alkanes Alcohol polyethers -23, C12-13 Pareths -3, C12-14 Pareths -7, Butyrospermum parkii fruit fat, Burdok root P.E, Phellinus linteus extract, purslane extract, soluble collagen, xanthans, Sodium Hyaluronate, elegant jessamine root extract, storehouse Drag-line aloe leaf juice, Ligusticum wallichii, glycyrrhiza glabra root extract, Chinese herbaceous peony root extract, cetanol, ceteth -20, stearyl alcohol gather Ether -20, polysorbate -60, hydrolecithin, kawakaw leaf/root/stem extraction, essence, bisabolol, hydrogenation lecithin Fat, thorn A Gan trees benevolence oil, carbonic acid dioctyl ester, sucrose distearate, hydrolecithin, panthenol, gossypose, folic acid, cholesterine, Cer NP, Phenoxyethanol, tocopherol acetate, adenosine.

Further, epoxychloropropane hydrolysis, the glycerine for the sodium chloride-containing that generation glycerol content is 5-20% are carried out in solution Aqueous solution, concentrated, desalination, distillation, obtain the glycerine in raw material.

Further, Ligusticum wallichii is gathered in Grain Full to Grain in Ear, is then done with heated kang, stirred 1 time up and down daily during a heatable brick bed, through 2-3 After it, when giving out warmth odor, it is put into tremble in bamboo basket and hits, cleared silt and fibrous root, is put into pulverizer and crushes, and obtain in raw material Ligusticum wallichii.

Further, 0.1% aqueous sulfuric acid is heated to 60 DEG C, in 1,2- epoxy butanes are added dropwise in 1h, at 60-70 DEG C Insulation reaction 0.5h, pH7-7.5 is neutralized to 40% liquid caustic soda, after decompression boils off water, then through rectifying, collects 110 DEG C, 3.72kPa points Evaporate and obtain the butanediol in raw material.

Further, in the glycyrrhiza glabra root extract containing glycyrrhizin, glycyrrhizic acid, liquiritin, flavonoids of Glycyrrhiza, Curtain is than wingceltis element, formoononetin and Quercetin afterwards.

Further, summer, the dry root of two season of autumn excavation ranunculaceae plant Chinese herbaceous peony, clean, remove end to end and radicula, put boiling After being boiled in water, boiled again after removing crust or peeling, dry, be then placed in pulverizer and crush, crossed 50 mesh sieves, then use fine powder Ultrasonic extraction extracts, and obtains the Chinese herbaceous peony root extract in raw material.

Further, cockscomb fragment is added in acetone, soaked overnight to cockscomb dehydration is hardened, and is subsequently placed in porcelain dish It is dried, is ground into powdery through pulverizer after drying, cockscomb powder is poured into enamel pot, adds 6~7 times of distilled water, stirring Uniformly, more than 24h is soaked, cockscomb powder is fully swollen, then filters, collects filtrate, filter residue soaks 3 times in the same way again, Merge 3 filtered fluids, then filtrate is poured into ceramic cylinder, stir the solid sodium chloride of lower addition 10%, and add isometric chlorine It is imitative, after stirring 3h, water phase is separated, 95% ethanol of 2 times of volumes is added into the water phase separated, is stirred evenly, stands more than 12h, Hyaluronic acid is settled out, sediment is then filtered dry, obtains crude product after dry, crude product is re-dissolved in the 0.1mol/L sodium chloride of 4 times of volumes In solution, pH=4.5~5 are adjusted with dilute hydrochloric acid, add isometric chloroform, after stratification, suction out upper strata aqueous phase, water phase PH=7.5 are adjusted with 8% sodium hydroxide solution, add pronase, 24h are kept the temperature at 37 DEG C, then extracted with isometric chloroform Handle 2 times, merging upper strata aqueous phase, lower floor's liquids recovery chloroform, it is molten to add 1% isometric cetylpyridinium chloride in water phase Liquid, stirs evenly, and staticly settles, filtering, collects precipitation, and precipitation is dissolved with the 0.4mol/L sodium chloride of 2~3 times of volumes again, mistake Filter, add 3 times of 95% ethanol of volume in filtrate, staticly settle, suck upper strata ethanol, lower floor is again with 95% ethanol repeated precipitation 2 Secondary, lower sediment thing hangs filter, dry, then is washed 2 times with acetone, is dried in vacuo, obtains the Sodium Hyaluronate in raw material.

Beneficial effects of the present invention：A kind of pouch maintenance elite composition containing polypeptide of the present invention, can delay eye Skin aging, improves edema and livid ring around eye, and anti-Hemostatic Oral Liquid is detained eye circumference, round-the-clock intensive moisturizing.Improve eye circumference skin water shortage to show As making eye circumference skin moment water profit flexible, so as to avoid the generation of dry line microgroove.

Embodiment

To make the technical means, the creative features, the aims and the efficiencies achieved by the present invention easy to understand, with reference to Embodiment, the present invention is further explained.

The present invention provides a kind of technical solution：A kind of pouch maintenance elite composition containing polypeptide, is made of following raw material： Water, ring five dimethyl silicone polymer, glycerine, aurantiamarin methyl chalcone, stereth -20, sodium citrate, two Portugal of Chlorhexidine Sugar lime, palmitoyl oligopeptide, potassium sorbate, citric acid, Matrixyl -4, dimethyl silicone polymer, five poly dimethyl silicon of ring Oxygen alkane, trideceth -6, stearine, 1,2- hexylene glycols, niacinamide, hydrogenation C6-14 polymerization of olefins species, Dimethyl silicone polymer, cetanol, glycine betaine, butanediol, C12-13 Pareths -23, C12-13 Pareths -3, C12-14 Pareths -7, Butyrospermum parkii fruit fat, Burdok root P.E, Phellinus linteus extract, purslane extraction Thing, soluble collagen, xanthans, Sodium Hyaluronate, elegant jessamine root extract, aloe barbadensis Miller leaf juice, Ligusticum wallichii, glycyrrhiza glabra root carry Take thing, Chinese herbaceous peony root extract, cetanol, ceteth -20, stereth -20, polysorbate -60, hydrogenation lecithin Fat, kawakaw leaf/root/stem extraction, essence, bisabolol, hydrolecithin, thorn A Gan trees benevolence oil, carbonic acid dioctyl ester, sugarcane Sugared distearate, hydrolecithin, panthenol, gossypose, folic acid, cholesterine, Cer NP, Phenoxyethanol, tocopherol second Acid esters, adenosine.

Epoxychloropropane hydrolysis, the glycerine water solution for the sodium chloride-containing that generation glycerol content is 5-20%, warp are carried out in solution Concentration, desalination, distillation, obtain the glycerine in raw material.

Ligusticum wallichii is gathered in Grain Full to Grain in Ear, is then done with heated kang, stirs 1 time during a heatable brick bed, after 2-3 days, is distributed up and down daily When going out warmth odor, it is put into tremble in bamboo basket and hits, cleared silt and fibrous root, is put into pulverizer and crushes, and obtain the Ligusticum wallichii in raw material.

0.1% aqueous sulfuric acid is heated to 60 DEG C, in 1,2- epoxy butanes are added dropwise in 1h, in 60-70 DEG C of insulation reaction 0.5h, is neutralized to pH7-7.5 with 40% liquid caustic soda, depressurizes after boiling off water, then is fractionated and obtains former through rectifying, 110 DEG C of collection, 3.72kPa Butanediol in material.

Containing glycyrrhizin, glycyrrhizic acid in glycyrrhiza glabra root extract, liquiritin, flavonoids of Glycyrrhiza, rear curtain are than wingceltis element, thorn Onocerin and Quercetin.

Summer, the dry root of two season of autumn excavation ranunculaceae plant Chinese herbaceous peony, clean, remove end to end and radicula, put after being boiled in boiling water, Boiled again after removing crust or peeling, dry, be then placed in pulverizer and crush, crossed 50 mesh sieves, then carry fine powder with ultrasonic wave Extraction is followed the example of, obtains the Chinese herbaceous peony root extract in raw material.

Cockscomb fragment is added in acetone, soaked overnight to cockscomb dehydration is hardened, and is subsequently placed in porcelain dish and is dried, Powdery is ground into through pulverizer after drying, cockscomb powder is poured into enamel pot, 6~7 times of distilled water is added, stirs evenly, is soaked More than 24h, makes cockscomb powder fully be swollen, then filters, and collects filtrate, and filter residue soaks 3 times in the same way again, merges 3 mistakes Filtrate, then filtrate is poured into ceramic cylinder, the solid sodium chloride of lower addition 10% is stirred, and isometric chloroform is added, stir 3h Afterwards, water phase is separated, 95% ethanol of 2 times of volumes is added into the water phase separated, is stirred evenly, more than 12h is stood, is settled out Bright matter acid, is then filtered dry sediment, crude product is obtained after dry, crude product is re-dissolved in the 0.1mol/L sodium chloride solutions of 4 times of volumes, is used Dilute hydrochloric acid adjusts pH=4.5~5, adds isometric chloroform, after stratification, suctions out upper strata aqueous phase, water is mutually with 8% hydroxide Sodium solution adjusts pH=7.5, adds pronase, keeps the temperature 24h at 37 DEG C, then with isometric chloroform extraction processing 2 times, closes And upper strata aqueous phase, lower floor's liquids recovery chloroform, 1% isometric cetylpyridinium chloride solution is added in water phase, stirring is equal It is even, staticly settle, filter, collect precipitation, precipitation is dissolved with the 0.4mol/L sodium chloride of 2~3 times of volumes again, filtering, in filtrate 3 times of 95% ethanol of volume are added, are staticly settled, suck upper strata ethanol, again with 95% ethanol repeated precipitation 2 times, lower floor sinks for lower floor Starch hangs filter, dry, then is washed 2 times with acetone, is dried in vacuo, obtains the Sodium Hyaluronate in raw material.

As one embodiment of the present of invention：A kind of pouch maintenance elite composition containing polypeptide of the present invention, Ke Yiyan Slow eye skin aging, improves edema and livid ring around eye, and anti-Hemostatic Oral Liquid is detained eye circumference, round-the-clock intensive moisturizing.Improve eye circumference skin Water shortage phenomenon, makes eye circumference skin moment water profit flexible, so as to avoid the generation of dry line microgroove.

The basic principles, main features and the advantages of the invention have been shown and described above, for this area skill For art personnel, it is clear that the invention is not restricted to the details of above-mentioned one exemplary embodiment, and without departing substantially from the present invention spirit or In the case of essential characteristic, the present invention can be realized in other specific forms.Therefore, in all respects, should all incite somebody to action Embodiment regards exemplary as, and is non-limiting, the scope of the present invention by appended claims rather than on state Bright restriction, it is intended that including all changes fallen in the implication and scope of the equivalency of claim in the present invention It is interior.

Moreover, it will be appreciated that although the present specification is described in terms of embodiments, not each embodiment is only wrapped Containing an independent technical solution, this narrating mode of specification is only that those skilled in the art should for clarity Using specification as an entirety, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art It is appreciated that other embodiment.

Claims

A kind of 1. pouch maintenance elite composition containing polypeptide, it is characterised in that：It is made of following raw material：Water, five poly- diformazan of ring Radical siloxane, glycerine, aurantiamarin methyl chalcone, stereth -20, sodium citrate, chlorhexidine digluconate, palmityl Oligopeptides, potassium sorbate, citric acid, Matrixyl -4, dimethyl silicone polymer, ring five dimethyl silicone polymer, tridecanol Polyethers -6, stearine, 1,2- hexylene glycols, niacinamide, hydrogenation C6-14 polymerization of olefins species, polydimethylsiloxanes Alkane, cetanol, glycine betaine, butanediol, C12-13 Pareths -23, C12-13 Pareths -3, C12-14 alkanes Alcohol polyethers -7, Butyrospermum parkii fruit fat, Burdok root P.E, Phellinus linteus extract, purslane extract, soluble glue Original, xanthans, Sodium Hyaluronate, elegant jessamine root extract, aloe barbadensis Miller leaf juice, Ligusticum wallichii, glycyrrhiza glabra root extract, Peony Root Extract, cetanol, ceteth -20, stereth -20, polysorbate -60, hydrolecithin, kawakaw Leaf/root/stem extraction, essence, bisabolol, hydrolecithin, thorn A Gan trees benevolence oil, carbonic acid dioctyl ester, sucrose distearyl acid Ester, hydrolecithin, panthenol, gossypose, folic acid, cholesterine, Cer NP, Phenoxyethanol, tocopherol acetate, adenosine.
A kind of 2. pouch maintenance elite composition containing polypeptide according to claim 1, it is characterised in that：Carried out in solution Epoxychloropropane hydrolyzes, and the glycerine water solution for the sodium chloride-containing that generation glycerol content is 5-20%, concentrated, desalination, distillation, obtain Glycerine in raw material.
A kind of 3. pouch maintenance elite composition containing polypeptide according to claim 1, it is characterised in that：In Grain Full to awns Kind of collection Ligusticum wallichii, is then done with heated kang, stirs 1 time up and down daily during a heatable brick bed, after 2-3 days, when giving out warmth odor, be put into bamboo basket Inside tremble and hit, cleared silt and fibrous root, are put into pulverizer and crush, and obtain the Ligusticum wallichii in raw material.
A kind of 4. pouch maintenance elite composition containing polypeptide according to claim 1, it is characterised in that：By 0.1% sulfuric acid Aqueous solution is heated to 60 DEG C, in 1,2- epoxy butanes are added dropwise in 1h, in 60-70 DEG C of insulation reaction 0.5h, is neutralized to 40% liquid caustic soda PH7-7.5, is depressurized after boiling off water, then is fractionated through rectifying, 110 DEG C of collection, 3.72kPa and is obtained the butanediol in raw material.
A kind of 5. pouch maintenance elite composition containing polypeptide according to claim 1, it is characterised in that：The smooth fruit is sweet Containing glycyrrhizin, glycyrrhizic acid in grass roots extract, liquiritin, flavonoids of Glycyrrhiza, rear curtain are than wingceltis element, formoononetin and Mongolian oak Pi Su.
A kind of 6. pouch maintenance elite composition containing polypeptide according to claim 1, it is characterised in that：Summer, Qiu Erji The dry root of ranunculaceae plant Chinese herbaceous peony is excavated, is cleaned, removes end to end and radicula, puts after being boiled in boiling water, after removing crust or peeling Boil, dry again, be then placed in pulverizer and crush, cross 50 mesh sieves, then extract fine powder with ultrasonic extraction, obtain raw material In Chinese herbaceous peony root extract.
A kind of 7. pouch maintenance elite composition containing polypeptide according to claim 1, it is characterised in that：By cockscomb fragment It is added in acetone, soaked overnight to cockscomb dehydration is hardened, and is subsequently placed in porcelain dish and is dried, is crushed after dry through pulverizer Powdering, cockscomb powder is poured into enamel pot, is added 6~7 times of distilled water, is stirred evenly, and is soaked more than 24h, is filled cockscomb powder Divide swelling, then filter, collect filtrate, filter residue soaks 3 times in the same way again, merges 3 filtered fluids, then filtrate is poured into pottery In Porcelain Jar, stir it is lower add 10% solid sodium chloride, and add isometric chloroform, after stirring 3h, separate water phase, to separating Water phase in add 2 times of volumes 95% ethanol, stir evenly, stand more than 12h, be settled out hyaluronic acid, be then filtered dry precipitation Thing, it is dry after crude product, crude product are re-dissolved in the 0.1mol/L sodium chloride solutions of 4 times of volumes, with dilute hydrochloric acid adjust pH=4.5~ 5, add isometric chloroform, after stratification, suction out upper strata aqueous phase, water mutually with 8% sodium hydroxide solution adjusting pH=7.5, Pronase is added, keeps the temperature 24h at 37 DEG C, then with isometric chloroform extraction processing 2 times, merges upper strata aqueous phase, subnatant Body recycles chloroform, adds 1% isometric cetylpyridinium chloride solution in water phase, stirs evenly, staticly settle, and filters, and receives Collection precipitation, precipitation are dissolved with the 0.4mol/L sodium chloride of 2~3 times of volumes again, filtering, and 3 times of 95% second of volume are added in filtrate Alcohol, staticly settles, and sucks upper strata ethanol, and again with 95% ethanol repeated precipitation 2 times, lower sediment thing hangs filter, dry, then uses for lower floor Acetone washs 2 times, and vacuum drying, obtains the Sodium Hyaluronate in raw material.