CN107868071B - 7,8-二羟黄酮和7,8-取代的黄酮衍生物、组合物及其相关方法 - Google Patents

7,8-二羟黄酮和7,8-取代的黄酮衍生物、组合物及其相关方法 Download PDF

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CN107868071B
CN107868071B CN201711170821.XA CN201711170821A CN107868071B CN 107868071 B CN107868071 B CN 107868071B CN 201711170821 A CN201711170821 A CN 201711170821A CN 107868071 B CN107868071 B CN 107868071B
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CN107868071A (zh
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叶克强
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Emory University
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    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
    • C07D311/36—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only not hydrogenated in the hetero ring, e.g. isoflavones
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/34—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 3 only
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CN201711170821.XA 2012-11-05 2013-11-01 7,8-二羟黄酮和7,8-取代的黄酮衍生物、组合物及其相关方法 Active CN107868071B (zh)

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US201261722339P 2012-11-05 2012-11-05
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US201361845399P 2013-07-12 2013-07-12
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CN201380062367.XA CN104812744B (zh) 2012-11-05 2013-11-01 7,8‑二羟黄酮和7,8‑取代的黄酮衍生物、组合物及其相关方法

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CN110790739B (zh) * 2018-08-01 2021-10-01 陕西麦科奥特科技有限公司 用于治疗神经系统疾病的化合物及其应用
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CN109574975B (zh) * 2019-01-14 2023-07-14 上海博芮健制药有限公司 7,8-二羟基黄酮衍生物的晶型及其制备方法和应用
WO2020154434A1 (en) * 2019-01-24 2020-07-30 Pharmatrophix, Inc. Compositions and methods for treating and preventing cognitive dysfunction
CN111825649A (zh) * 2019-04-15 2020-10-27 上海博芮健制药有限公司 7,8-二羟基黄酮衍生物的纯化方法
CN114075162A (zh) * 2020-08-20 2022-02-22 上海博芮健制药有限公司 7,8-二羟基黄酮衍生物的晶型b及其制备方法、应用
CN112168976B (zh) * 2020-10-15 2022-11-04 天津科技大学 一种黄酮衍生物前药及合成和作为抗肿瘤药物的应用
WO2023288069A1 (en) * 2021-07-15 2023-01-19 Emory University Methods of using substituted flavones for treating bone disorders
WO2023072228A1 (en) * 2021-10-29 2023-05-04 Tsinghua University Methods and products for treating or diagnosing schizophrenia
TW202334089A (zh) 2021-11-02 2023-09-01 美商夫雷爾醫療公司 Ｐｐａｒｇ反向激動劑及其用途
WO2024097205A1 (en) * 2022-11-02 2024-05-10 Petra Pharma Corporation Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of disease

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JP2021050230A (ja) 2021-04-01
AU2013337742B2 (en) 2017-11-23
AU2019213454A1 (en) 2019-08-29
US20180186762A1 (en) 2018-07-05
CN104812744B (zh) 2017-12-01
AU2013337742A1 (en) 2015-05-21
EP2914585A1 (en) 2015-09-09
AU2019213454B2 (en) 2020-07-09
CN104812744A (zh) 2015-07-29
EP2914585A4 (en) 2016-03-23
US20170305876A1 (en) 2017-10-26
EP3369730A1 (en) 2018-09-05
US9682948B2 (en) 2017-06-20
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US10526303B2 (en) 2020-01-07
JP6479670B2 (ja) 2019-03-06
US20150274692A1 (en) 2015-10-01
CA2890075C (en) 2021-01-05
CA2890075A1 (en) 2014-05-08
EP2914585B1 (en) 2018-03-07
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US9975868B2 (en) 2018-05-22
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