CN107854663A - 一种治疗瘢痕增生的药物 - Google Patents
一种治疗瘢痕增生的药物 Download PDFInfo
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Abstract
本发明公开了一种促进伤口愈合的中药组合物,涉及中药技术领域,其由广钩藤、天花粉、木棉花、车前草、地耳草、茉莉花、青天葵、青蒿、构树根、垂盆草、鸭跖草、金花茶叶、猫爪草、白花蛇舌草、九里香、鱼腥草、蒲公英、岩黄连、穿花针、莪术、鬼画符、薏苡仁、肿节风、毛郁金、马鞭草、叶下珠、灯心草、艾叶等药材制备而成。本发明的药物组合物具有消肿止痛、杀菌消炎、敛疮生肌、防治伤口感染,伤口愈合时间短,防治瘢痕增生的优点。
Description
技术领域
本发明属于中药技术领域,具体涉及一种治疗瘢痕增生的中药组合物。
背景技术
创伤性伤口是急、门诊最常见的外伤之一,创伤性伤口的感染是医院感染中最常见的感染之一。外科手术后的手术切口轻度感染会造成切口延期愈合,增加患者疼痛,手术切口重度感染则可能会引起切口裂开甚至会引起全身性感染危及到生命。中医认为伤口感染是外感风操湿火,即热壅聚,湿热火毒内生,或因肝脾血热兼忿怒气郁,导致气凝滞,经脉壅阻而成。现代现有外伤处理方法或处理药物,处理过程繁琐,伤口愈合缓慢,愈合后多数会留下严重的疤痕,影响美观,尤其是在面部等外观部位。
发明内容
鉴于现有技术的不足,本发明的目的在于提供一种治疗瘢痕增生的药物。
本发明还提供了各味药材的重量份配比:广钩藤20份、天花粉16份、木棉花15份、车前草10份、地耳草18份、茉莉花20 份、青天葵10份、青蒿10份、构树根25份、垂盆草10份、鸭跖草20份、金花茶叶50份、猫爪草30份、白花蛇舌草60份、九里香25份、鱼腥草40份、蒲公英20份、岩黄连15份、穿花针15份、莪术15份、鬼画符15份、薏苡仁25份、肿节风10份、毛郁金15份、马鞭草10份、叶下珠10份、灯心草15份、艾叶50份。(所述药材原料均出自《广西壮族自治区壮药质量标准》)
本发明中药组合物可制备成外用剂型。
所述的外用剂型优选为油剂、糊剂或膏剂。
本发明油剂使用方法:根据伤口大小剪取油纸,将本发明中药组合物油剂均匀涂抹在上面,然后覆盖创面即可,每天换药 1 次;或者用本发明油剂直接涂抹创面,每天 3-4次。直至伤口愈合或拆线。
本发明的药物组合物具有消肿止痛、杀菌消炎、敛疮生肌、防治伤口感染,伤口愈合时间短,防治瘢痕增生的优点。
具体实施方式
实施例1
一种治疗瘢痕增生的药物,由如下重量份的原料制成:
广钩藤20份、天花粉16份、木棉花15份、车前草10份、地耳草18份、茉莉花20 份、青天葵10份、青蒿10份、构树根25份、垂盆草10份、鸭跖草20份、金花茶叶50份、猫爪草30份、白花蛇舌草60份、九里香25份、鱼腥草40份、蒲公英20份、岩黄连15份、穿花针15份、莪术15份、鬼画符15份、薏苡仁25份、肿节风10份、毛郁金15份、马鞭草10份、叶下珠10份、灯心草15份、艾叶50份。
本发明促进伤口愈合的油剂,疗效确切,有效率高,特别适用于伤口久不愈合的患者,已治愈各类患者 1000 余例。
临床实验数据
1、临床资料 :
连续选取 2015 年 7 月 -2017 年 7 月在本院急诊、门诊因创伤性伤口而就诊的患者280 例,随机分为实验组和对照组。 实验组 200 例,年龄 6 岁 -74 岁,平均年龄 34.1±7.8岁。 其中面部伤口 38 例,躯干 28 例,四肢 134 例 ;伤口长度小于 5cm 者 154例,伤口长度大于 5cm 者 46 例,伤口深度在 0.5cm 以内者 163 例,伤口深度在 0.5cm-1.0cm 者 37 例。 对照组 80 例,年龄 6 岁 -72 岁,平均年龄 34.8±7.1 岁。 其中面部伤口 15 例,躯干 11 例,四肢54 例 ;伤口长度小于 5cm 者 63 例,伤口长度大于 5cm者 17 例,伤口深度在 0.5cm 以内者 64例,伤口深度在 0.5cm-1.0cm 者 16 例。 以上患者均因外伤致开放性伤口流血、疼痛就诊,直至痊愈。 两组患者性别、年龄、伤口部位、缝合针数、创伤程度等进行比较,经 X2 检验,无显著性差异 (P > 0.05),具有可比性。
2、治疗方法 :
实验组 :对创伤性伤口清创或者缝合后,根据伤口大小剪取油纸,按本发明实施例1配比的药物,按常规方法制得的油剂均匀地铺在上面,然后覆盖创面,每天换药 1 次 ;或者用本发明油剂直接涂抹创面,每天 3-4 次。 直至伤口愈合或拆线。
对照组 : 对创伤性伤口清创或者缝合后,用 5%碘伏消毒创面及周围皮肤,敷上酒精纱布,每天换敷料 1 次。
3、实验结果 :
两组止血、消肿、止痛效果比较。
实验组中 200 例患者创口外敷本发明油剂后,可迅速止血、止痛、消肿,与对照组具有极显著性差异 ( 见表 1)。 且实验组换药或拆线时无痛感或轻微痛感。 而对照组患者在更换敷料或拆线时,有不同程度的痛感。
表 1 两组治疗效果
备注 :* 表示与对照组比较 P < 0.01。
两组伤口感染、伤口愈合情况比较。
经过治疗后,实验组无一例发生感染,平均 5 天拆线,Ⅰ期愈合率可达 99%。 对照组平均 8 天拆线,Ⅰ期愈合率仅为 71%,且有 8 例伤口发生感染。 详见表 2.
表 2 两组伤口感染、伤口愈合情况
组别 | 病例数 | 伤口感染 | Ⅰ期愈合 | Ⅱ期愈合 |
实验组 | 200 | 0 | 198 | 2 |
对照组 | 80 | 8 | 57 | 23 |
注 :Ⅰ期愈合是指组织修复以原来的细胞为主,仅含有少量纤维组织,局部无感染,血肿或坏死,组织再生过程迅速,结构和功能修复良好。 Ⅱ期愈合是指组织缺损大、创缘不整、哆开、无法整齐对合,或伴有感染的伤口的愈合。
可见本发明中药组合物油剂在防止伤口感染方面效果显著,有助于伤口愈合。 此外,实验组患者拆线后,继续涂抹本发明中药组合物油剂 30 天后,有 80%以上的患者瘢痕消失。 治疗组患者拆线一个月后,仅有 5%的患者瘢痕消失。
Claims (1)
1.一种治疗瘢痕增生的药物,由如下重量份的原料制成:
广钩藤20份、天花粉16份、木棉花15份、车前草10份、地耳草18份、茉莉花20 份、青天葵10份、青蒿10份、构树根25份、垂盆草10份、鸭跖草20份、金花茶叶50份、猫爪草30份、白花蛇舌草60份、九里香25份、鱼腥草40份、蒲公英20份、岩黄连15份、穿花针15份、莪术15份、鬼画符15份、薏苡仁25份、肿节风10份、毛郁金15份、马鞭草10份、叶下珠10份、灯心草15份、艾叶50份。
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CN102038733A (zh) * | 2010-12-17 | 2011-05-04 | 华中科技大学 | 一种用于治疗增生性瘢痕的外用中药及其制备方法 |
CN103203000A (zh) * | 2013-03-04 | 2013-07-17 | 余金标 | 一种治疗瘢痕疙瘩的药膏 |
CN104546917A (zh) * | 2014-12-25 | 2015-04-29 | 杨淑珍 | 一种抑制瘫痕增生的烫烧伤外用药物 |
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CN103203000A (zh) * | 2013-03-04 | 2013-07-17 | 余金标 | 一种治疗瘢痕疙瘩的药膏 |
CN104546917A (zh) * | 2014-12-25 | 2015-04-29 | 杨淑珍 | 一种抑制瘫痕增生的烫烧伤外用药物 |
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