CN107823329A - Treat Chinese medicine composition of hypertension and preparation method thereof - Google Patents
Treat Chinese medicine composition of hypertension and preparation method thereof Download PDFInfo
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- CN107823329A CN107823329A CN201711129946.8A CN201711129946A CN107823329A CN 107823329 A CN107823329 A CN 107823329A CN 201711129946 A CN201711129946 A CN 201711129946A CN 107823329 A CN107823329 A CN 107823329A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Abstract
The invention discloses Chinese medicine composition and preparation method thereof for the treatment of hypertension, belong to the treatment by Chinese herbs field of hypertension.The present invention discloses a kind of Chinese medicine composition for treating hypertension first, including:The root bark of white mulberry and the root bark of Chinese wolf-berry.The present invention further discloses a kind of method for preparing the Chinese medicine composition, comprise the following steps:After each component is mixed into immersion, add water to be decocted, filter, collect filtrate, produce.Clinical efficacy result shows, definite the effect of the traditional Chinese medicine composition for treating hypertension that the present invention is prepared by the root bark of white mulberry with root bark of Chinese wolf-berry compatibility, treats obvious effective rate and reaches more than 90%.Prove, there is obvious synergistic function between the root bark of white mulberry and the root bark of Chinese wolf-berry.The compatibility of Chinese medicine composition of the present invention is reasonable, has no toxic side effect, and preparation method is simple.
Description
Technical field
The present invention relates to the Chinese medicine composition for the treatment of hypertension, the preparation method of the Chinese medicine composition is further related to, is belonged to
The treatment by Chinese herbs field of hypertension.
Background technology
Majority is essential hypertension in Hypertensive Population., can based on current medical development level and detection methods
It was found that cause the elevated definite cause of disease of blood pressure, referred to as secondary hypertension;Conversely, it can not find to cause blood pressure elevated definite
The cause of disease, then referred to as essential hypertension.It is now recognized that essential hypertension is a kind of some congenital hereditary genes and many causes
Characteristic of disease is pressurized multi-factor disease caused by factor and physiological decompression factor interaction, and these factors mainly include:Heredity
It is the low potassium meals of factor, high sodium, overweight and fat etc..American Society of Hypertension (ASH) proposition in 2005, hypertension is one by being permitted
The cardiovascular syndrome of continuous state of progress is in caused by multi-pathogenesis, the change of heart and vascular function and structure can be caused.
Therefore, the main purpose of essential hypertension treatment is to reduce cardiovascular dead and invalid total danger to greatest extent.
The medicament categories of existing treatment hypertension are various, but exist uncertain therapeutic efficacy cut, work that slow, side effect is big etc. it is scarce
Fall into.Therefore, exploitation is a kind of treats the Chinese medicine composition that hypertension is curative for effect and has no side effect, before with important application
Scape.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of Chinese medicine composition for treating hypertension, the Chinese medicine composition
Treatment total effective rate to hypertension is high, curative for effect, and has no side effect;
Another technical problem to be solved by this invention is to provide a kind of preparation method of the Chinese medicine composition.
In order to solve the above technical problems, the technical solution used in the present invention is:
The present invention discloses a kind of Chinese medicine composition for treating hypertension, including following each component first:The root bark of white mulberry and ground
Bone skin.The parts by weight of each component are:Root bark of white mulberry 10-50 parts, root bark of Chinese wolf-berry 10-50 parts.As the preferred technical solution of the present invention, respectively
The parts by weight of component are:30 parts of the root bark of white mulberry, 30 parts of the root bark of Chinese wolf-berry.
The root bark of white mulberry, the root skin of cork is removed for moraceae plants mulberry.Nature and flavor are sweet, tremble with fear.Enter lung, the spleen channel.Major function:Purging the lung of pathogenic fire is put down
Asthma, line water detumescence.Dyspnea and cough due to lung-heat is controlled, is spitted blood, oedema, tinea pedis, difficult urination.
The root bark of Chinese wolf-berry, it is matrimony vine of solanaceae plant Lycium chinense Mill. or lycium barbarum Lycium barbarum
L. dry root skin.Nature and flavor are sweet, tremble with fear.Return lung, liver and kidney channel.Major function:Cool blood is except steaming, clearing lung-heat fall fire.For deficiency of Yin hectic fever,
Hectic fever due to yin night sweat, cough with lung heat, spitting of blood, bleeding from five sense organs or subcutaneous tissue, Heat Diabetes.
The Chinese medicine composition that the present invention is prepared by the root bark of white mulberry and root bark of Chinese wolf-berry compatibility, has clearing liver fall fire, the work(of phencyclidine
Effect, it can be used in treating essential hypertension or secondary hypertension, preferably essential hypertension.Sent out based on current medical science
Exhibition is horizontal and detection methods, it is impossible to which discovery causes the elevated definite cause of disease of blood pressure, then referred to as essential hypertension.Cardinal symptom bag
Include:Headache, dizziness, irritable are thirsty, tongue is red, yellow and greasy fur, veins string etc., belong to that deficiency of Yin sun is anti-or the hypertension of convulsive seizure due to phlegm-fire life wind.
Based on current medical development level and detection methods, it can be found that causing the elevated definite cause of disease of blood pressure, referred to as Secondary cases
Hypertension.
The present invention further discloses a kind of preparation method of the Chinese medicine composition, comprise the following steps:(1) by each group
Divide mixing, soak;(2) each component after immersion is pulled out, adds water to be decocted, filtered, collected filtrate, produce.
Wherein, the time of step (1) described immersion is 10-60nin;The time of step (2) described decoction is 20-50min,
The number of the decoction is 1-5 times.Preferably, the time of step (1) described immersion is 30nin;Step (2) described decoction when
Between be 30min, the number of the decoction is 3 times;Obtained filtrate mixing will be decocted every time, produce.The present invention is to used in immersion
The amount of water is not particularly limited, and does not have medicinal material to be advisable with water.It is of the invention that the amount of water is preferably the root bark of white mulberry and ground used in decoction every time
3 times of 2-10 times of bone skin gross mass, the most preferably root bark of white mulberry and root bark of Chinese wolf-berry gross mass.
The comparative result of clinical efficacy shows that the Chinese medicine composition that the present invention is prepared by the root bark of white mulberry and root bark of Chinese wolf-berry compatibility is to original
Essential hypertension has definite therapeutic effect, treats the obvious effective rate of essential hypertension up to 92%, and total effective rate is up to 100%;Its
The Chinese medicine composition that obvious effective rate and total effective rate are prepared apparently higher than other bulk drug compatibilities such as the root bark of white mulberry and bluish dogbane or rhizoma Gastrodiae,
It has been respectively increased more than 20 percentage points.Result above proves between the root bark of white mulberry and the root bark of Chinese wolf-berry there is obvious Synergistic to make
With.In addition, Chinese medicine composition of the present invention has no toxic side effect, the hyperpietic of Chinese medicine composition of the present invention is taken in therapeutic process
In do not occur adverse reaction, blood pressure has no bounce-back after being discontinued 2 months.
Clinical diagnosis takes the present invention by the root bark of white mulberry and the Chinese medicine of root bark of Chinese wolf-berry compatibility preparation for the patient of secondary hypertension
Composition, for the obvious effective rate for the treatment of 30 days up to 90.6%, total effective rate is curative for effect up to 100%.
The invention also discloses purposes of the described Chinese medicine composition in the medicine for preparing treatment hypertension.Wherein, institute
Stating hypertension includes:Essential hypertension or secondary hypertension, preferably essential hypertension.
Suitable auxiliary material or carrier are added on the basis of Chinese medicine composition of the present invention can be prepared into different dosage forms
Treatment hypertension medicine.The formulation of the medicine includes but is not limited to:It is electuary, tablet, pill, granule, soft capsule, hard
Capsule or microcapsules.
Auxiliary material or carrier of the present invention refer to the conventional carrier or auxiliary material of pharmaceutical field, such as:Diluent, burst apart
Agent, lubricant, excipient, adhesive, glidant, filler, surfactant, flavouring agent, sweetener etc..Conventional diluent
Including lactose, starch, microcrystalline cellulose, sorbierite, mannitol and inorganic calcium salt etc..The disintegrant can be to be crosslinked poly- second
One of alkene pyrrolidone, Ac-Di-Sol, alginic acid, microcrystalline cellulose are planted or several mixtures.Described profit
Lubrication prescription includes one kind in stearic acid, odium stearate, magnesium stearate, calcium stearate, polyethylene glycol, talcum powder, hydrogenated vegetable oil
Or several mixtures.Described adhesive can be starch slurry, hydroxypropyl methyl cellulose or polyvinylpyrrolidone.It is described to help
It can be one or more of mixtures in superfine silica gel powder, talcum powder, magnesium trisilicate to flow agent.The surfactant can be one
Kind or several compositions that can be improved wetability and increase drug-eluting are conventional for lauryl sodium sulfate.
The bulk drug root bark of white mulberry, the root bark of Chinese wolf-berry used in the present invention can be commercially available in pharmacy.
The usage and dosage of Chinese medicine composition of the present invention:The present invention dosage depend on specific formulation, patient age,
The factors such as health status.As guidance, usage and dosage:It is dose to take root bark of white mulberry 30g, root bark of Chinese wolf-berry 30g, with being decocted in water for oral dose;Daily
Take 2 times, 15 days are a course for the treatment of.For intractable hypertension, the dosage of the root bark of white mulberry and the root bark of Chinese wolf-berry can add in every dose of medicine
50g。
Technical solution of the present invention compared with prior art, has the advantages that:
The compatibility of Chinese medicine composition of the present invention is reasonable, has obvious Synergistic between the bulk drug root bark of white mulberry and the root bark of Chinese wolf-berry
Effect, the obvious effective rate and total effective rate for the treatment of hypertension can be significantly improved.The preparation technology of Chinese medicine composition of the present invention is simple,
Have no toxic side effect, treat hypertension the effect of it is definite, have a good application prospect.
Embodiment
The invention will now be further described with reference to specific embodiments, advantages of the present invention and feature will be with description and
It is apparent.It should be understood that the embodiment is only exemplary, any restrictions are not formed to the scope of the present invention.This area
Technical staff should be understood that without departing from the spirit and scope of the invention can to the details of technical solution of the present invention and
Form is modified or replaced, but these modifications or substitutions each fall within protection scope of the present invention.
The preparation of the oral liquid of embodiment 1
Each component (g) is weighed according to following ratio:The root bark of white mulberry 10, the root bark of Chinese wolf-berry 10;
Preparation method comprises the following steps:The root bark of white mulberry and the root bark of Chinese wolf-berry are mixed, 10nin is soaked and (did not had medicinal material with water
It is advisable);Then each component after immersion is pulled out, adds 40g decoctings to boil 1 time, the time of decoction is 20min, filtering, collects filter
Liquid, produce.
Usage and dosage:Daily 2 times, once in the morning and once at night.
The preparation of the oral liquid of embodiment 2
Each component (g) is weighed according to following ratio:The root bark of white mulberry 50, the root bark of Chinese wolf-berry 50;
Preparation method comprises the following steps:The root bark of white mulberry and the root bark of Chinese wolf-berry are mixed, 60nin is soaked and (did not had medicinal material with water
It is advisable);Then each component after immersion is pulled out, adds 1000g decoctings to boil 50min, filtered, collect filtrate, it is standby;By filter residue again
Add 1000g decoctings to boil 50min, filter, collect filtrate, it is standby;Above-mentioned decoction step is repeated, decocts 5 times, will decoct every time altogether
Obtained filtrate mixing, is produced.
Usage and dosage:Daily 2 times, once in the morning and once at night.
The preparation of the oral liquid of embodiment 3
Each component (g) is weighed according to following ratio:The root bark of white mulberry 30, the root bark of Chinese wolf-berry 30;
Preparation method comprises the following steps:The root bark of white mulberry and the root bark of Chinese wolf-berry are mixed, 30nin is soaked and (did not had medicinal material with water
It is advisable);Then each component after immersion is pulled out, adds 180g decoctings to boil 30min, filtered, collect filtrate, it is standby;By filter residue again
Add 180g decoctings to boil 30min, filter, collect filtrate, it is standby;Above-mentioned decoction step is repeated, decocts 3 times, will decoct every time altogether
Obtained filtrate mixing, is produced.
Usage and dosage:Daily 2 times, once in the morning and once at night.
The preparation of the tablet of embodiment 4
Chinese medicine composition 15g prepared by Example 3, the medicinal extract that relative density is 1.3-1.4 (80 DEG C) is concentrated under reduced pressure into,
Starch 15g is added, is well mixed, then is well mixed with dextrin 30g, adds ethanol (50%) softwood processed in right amount;Pass through 16 mesh Buddhist nuns
Imperial sieve series grain, in 60 DEG C of dryings, dry granular adds 5 grams of magnesium stearate, tabletting after being well mixed after 16 mesh sieve whole grains.
The effect observation of the traditional Chinese medicine composition for treating hypertension of test example 1
By the patient 700 that clinical diagnosis is essential hypertension, patients' blood is above normal value (normal value 140/
Below 90mmHg), cardinal symptom is headache, and dizziness, irritable are thirsty, tongue is red, yellow and greasy fur, veins string etc., are randomly divided into 14 groups
(each group patient no significant difference (P in terms of sex, age and the state of an illness>0.05), there is comparativity), wherein 1 group is
Control group, without any drug therapy, another 13 groups of patients take according to following Chinese medicine composition 1-13 (raw material dosage lists respectively
Position:G) according to the method for embodiment 3 prepared by oral liquid:
Chinese medicine composition 1:The root bark of white mulberry 30, the root bark of Chinese wolf-berry 30;
Chinese medicine composition 2:The root bark of white mulberry 30, bluish dogbane 30;
Chinese medicine composition 3:The root bark of white mulberry 30, rhizoma Gastrodiae 30;
Chinese medicine composition 4:The root bark of white mulberry 30, sophora flower 30;
Chinese medicine composition 5:The root bark of white mulberry 30, sealwort 30;
Chinese medicine composition 6:The root bark of white mulberry 30, hawthorn 30;
Chinese medicine composition 7:The root bark of white mulberry 30, the root of kudzu vine 30;
Chinese medicine composition 8:The root bark of white mulberry 30, selfheal 30;
Chinese medicine composition 9:The root bark of white mulberry 30, the root bark of Chinese wolf-berry 30;
Chinese medicine composition 10:The root bark of white mulberry 30, the Radix Astragali 30;
Chinese medicine composition 11:The root bark of white mulberry 30, radix scutellariae 30;
Chinese medicine composition 12:The root bark of white mulberry 30, mulberry leaf 30;
Chinese medicine composition 13:The root bark of white mulberry 30, oriental wormwood 30;
The preparation method of each Chinese medicine composition is with embodiment 3, usage and dosage:Oral each Chinese medicine composition, takes daily
Twice, once in the morning and once at night;To treat 15d as 1 course for the treatment of, 2 courses for the treatment of count curative effect after terminating.
Efficacy assessment standard:
It is effective:Blood pressure is the malaise symptoms such as normal value (below 140/90mmHg), headache, dizziness, irritable after medication
Disappear or disappear substantially;
Effectively:Blood pressure before medication than reducing after medication, and the malaise symptoms such as headache, dizziness mitigate or partial disappearance;
It is invalid:Blood pressure does not have significant change before and after medication, even malaise symptoms do not mitigate, aggravated.
The comparative result of clinical efficacy is shown in Table 1.
Total effective rate/%=obvious effective rates+effective percentage.
The effect of the different traditional Chinese medicine composition for treating hypertension of table 1
As a result show, Chinese medicine composition 1 is notable to the therapeutic effect of essential hypertension, takes the trouble of Chinese medicine composition 1
Person, effective 46 people, obvious effective rate 92%;Effective 4 people, effective percentage are 8%, and total effective rate is up to 100%;Its obvious effective rate and it is total effectively
The Chinese medicine composition that rate is prepared apparently higher than other bulk drug compatibilities such as the root bark of white mulberry and bluish dogbane, has been respectively increased 20 percentage points
More than.Result above proves there is obvious synergistic function between the root bark of white mulberry and the root bark of Chinese wolf-berry.Moreover, take in the present invention
The hyperpietic of drug composition 1 does not occur serious adverse reaction in the treatment, to the blood of patient, urine, stool routine and liver, kidney
Function is checked, is showed no exception;Blood pressure has no bounce-back after being discontinued 2 months.
The traditional Chinese medicine composition for treating secondary hypertension of test example 2
The people of patient 106 by clinical diagnosis for secondary hypertension, take the Chinese medicine composition of the embodiment of the present invention 3, mouth
Clothes, twice daily, (blood pressure is normal value (below 140/90mmHg) to the obvious effective rate for the treatment of 30 days after medication, clinical malaise symptoms
Disappear or disappear substantially) it is 90.6%, total effective rate 100%.
Claims (10)
1. a kind of Chinese medicine composition for treating hypertension, it is characterised in that including following each component:The root bark of white mulberry and the root bark of Chinese wolf-berry.
2. according to the Chinese medicine composition described in claim 1, it is characterised in that the parts by weight of each component are:Root bark of white mulberry 10-50
Part, root bark of Chinese wolf-berry 10-50 parts.
3. according to the Chinese medicine composition described in claim 1, it is characterised in that the parts by weight of each component are:30 parts of the root bark of white mulberry,
30 parts of bone skin.
4. according to the Chinese medicine composition described in claim 1, it is characterised in that the hypertension includes:Essential hypertension or
Secondary hypertension;Preferably essential hypertension.
5. the preparation method of Chinese medicine composition described in a kind of Claims 1-4 any one, it is characterised in that including following step
Suddenly:(1) each component is mixed, soaked;(2) each component after immersion is pulled out, adds water to be decocted, filtered, collect filter
Liquid, produce.
6. according to the preparation method described in claim 5, it is characterised in that:The time of step (1) described immersion is 10-60nin;
The time of step (2) described decoction is 20-50min, and the number of the decoction is 1-5 times;Preferably, water used in decocting every time
Measure as 2-10 times of each component gross mass.
7. according to the preparation method described in claim 5, it is characterised in that:The time of step (1) described immersion is 30nin;Step
Suddenly the time of (2) described decoction is 30min, and the number of the decoction is 3 times;Preferably, the amount of water is each used in decocting every time
3 times of component gross mass.
8. purposes of the Chinese medicine composition in the medicine for preparing treatment hypertension described in Claims 1-4 any one.
9. according to the purposes described in claim 8, it is characterised in that the hypertension includes:Essential hypertension or Secondary cases
Hypertension;Preferably essential hypertension.
10. according to the purposes described in claim 8, it is characterised in that the formulation of the medicine includes:Electuary, tablet, pill,
Granule, soft capsule, hard shell capsules or microcapsules.
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101987169A (en) * | 2009-08-03 | 2011-03-23 | 大韩药品工业株式会社 | Composition comprising an extract of herbal combination thereof for preventing and treating diabetes mellitus |
KR101085540B1 (en) * | 2009-04-08 | 2011-11-24 | (주)애드바이오텍 | Cosmetic composition containing IgY from egg yolk for improvement of acene |
CN102284017A (en) * | 2011-08-15 | 2011-12-21 | 唐山康健生物科技有限公司 | Chinese medicinal preparation for reducing hypertension |
CN104666926A (en) * | 2013-12-02 | 2015-06-03 | 陕西康乐中医药养生研究院 | Hypertension improving agent |
-
2017
- 2017-11-15 CN CN201711129946.8A patent/CN107823329A/en not_active Withdrawn
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101085540B1 (en) * | 2009-04-08 | 2011-11-24 | (주)애드바이오텍 | Cosmetic composition containing IgY from egg yolk for improvement of acene |
CN101987169A (en) * | 2009-08-03 | 2011-03-23 | 大韩药品工业株式会社 | Composition comprising an extract of herbal combination thereof for preventing and treating diabetes mellitus |
CN102284017A (en) * | 2011-08-15 | 2011-12-21 | 唐山康健生物科技有限公司 | Chinese medicinal preparation for reducing hypertension |
CN104666926A (en) * | 2013-12-02 | 2015-06-03 | 陕西康乐中医药养生研究院 | Hypertension improving agent |
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Title |
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Application publication date: 20180323 |